@article{ChenLiWangetal.2012, author = {Chen, You-Peng and Li, Jian and Wang, Zi-Neng and Reichetzeder, Christoph and Xu, Hao and Gong, Jian and Chen, Guang-Ji and Pfab, Thiemo and Xiao, Xiao-Min and Hocher, Berthold}, title = {Renin angiotensin aldosterone system and glycemia in pregnancy}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {5-6}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, pages = {527 -- 533}, year = {2012}, abstract = {Background: The renin-angiotensin-aldosterone system (RAAS) is involved in the pathogenesis of insulin resistance and type 2 diabetes in the general population. The RAAS is activated during pregnancy. However, it is unknown whether the RAAS contributes to glycemia in pregnant women. Methods: Plasma renin activity (PRA) and plasma aldosterone levels were quantified at delivery in 689 Chinese mothers. An oral glucose tolerance test in fasted women was performed in the second trimester of pregnancy. The diagnosis of gestational diabetes mellitus (GDM) and impaired glucose tolerance during pregnancy were made according to the guidelines of the Chinese Society of Obstetrics. Results: Plasma aldosterone was significantly higher in pregnant women with GDM as compared to those without impairment of glycemic control (normal pregnancies: 0.27 +/- 0.21 ng/mL, GDM: 0.36 +/- 0.30 ng/mL; p<0.05). Regression analyses revealed that PRA was negatively correlated with fasting blood glucose (FBG) (R-2 = 0.03, p = 0.007), whereas plasma aldosterone and aldosterone/PRA ratio were positively correlated with FBG (R-2 = 0.05, p<0.001 and R-2 = 0.03, p = 0.007, respectively). Multivariable regression analysis models considering relevant confounding factors confirmed these findings. Conclusions: This study demonstrated that fasting blood glucose in pregnant women is inversely correlated with the PRA, whereas plasma aldosterone showed a highly significant positive correlation with fasting blood glucose during pregnancy. Moreover, plasma aldosterone is significantly higher in pregnant women with GDM as compared to those women with normal glucose tolerance during pregnancy. Although causality cannot be proven in association studies, these data may indicate that the RAAS during pregnancy contributes to the pathogenesis of insulin resistance/new onset of diabetes during pregnancy.}, language = {en} } @article{VukicevicVukovicStoyanovetal.2012, author = {Vukicevic, Radovan and Vukovic, Ivana and Stoyanov, Hristiyan and Korwitz, Andreas and Pospiech, Doris and Kofod, Guggi and Loos, Katja and ten Brinke, Gerrit and Beuermann, Sabine}, title = {Poly(vinylidene fluoride)-functionalized single-walled carbon nanotubes for the preparation of composites with improved conductivity}, series = {Polymer Chemistry}, volume = {3}, journal = {Polymer Chemistry}, number = {8}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1759-9954}, doi = {10.1039/c2py20166f}, pages = {2261 -- 2265}, year = {2012}, abstract = {The surface of single-walled carbon nanotubes (SWCNTs) was functionalized with azide-terminated poly(vinylidene fluoride) (PVDF). Functionalization was confirmed by dispersibility, Raman spectroscopy, and thermogravimetric analyses. Raman spectra show disordering of the SWCNTs, thus, strongly suggesting that PVDF was covalently attached to SWCNTs. Functionalized SWCNTs were mixed with commercially available PVDF in a twin-screw extruder and thin films were obtained by melt-pressing. Films containing 0.5 and 1 wt\% PVDF-functionalized SWCNTs exhibited significantly improved electrical conductivity compared to PVDF films containing pristine SWCNTs.}, language = {en} } @article{GirndtRieschSchroederetal.2012, author = {Girndt, Antje and Riesch, R{\"u}diger and Schr{\"o}der, Christiane and Sehlupp, Ingo and Plath, Martin and Tiedemann, Ralph}, title = {Multiple paternity in different populations of the sailfin molly, Poecilia latipinna}, series = {Animal biology}, volume = {62}, journal = {Animal biology}, number = {3}, publisher = {Brill}, address = {Leiden}, issn = {1570-7555}, doi = {10.1163/157075611X618192}, pages = {245 -- 262}, year = {2012}, abstract = {Rates of multiple paternities were investigated in the sailfin molly (Poecilia latipinna), using eight microsatellite loci. Genotyping was performed for offspring and mothers in 40 broods from four allopatric populations from the south-eastern U.S.A. along a geographic stretch of 1200 km in west-east direction and approximately 200 km from north to south. No significant differences regarding rates of multiple paternities were found between populations despite sample populations stemming from ecologically divergent habitats. Even the most conservative statistical approach revealed a minimum of 70\% of the broods being sired by at least two males, with an average of 1.80-2.95 putative fathers per brood. Within broods, one male typically sired far more offspring than would be expected under an assumed equal probability of all detected males siring offspring.}, language = {en} } @article{AydelottBaerHenneyTrzaskowskietal.2012, author = {Aydelott, Jennifer and Baer-Henney, Dinah and Trzaskowski, Maciej and Leech, Robert and Dick, Frederic}, title = {Sentence comprehension in competing speech dichotic sentence-word priming reveals hemispheric differences in auditory semantic processing}, series = {Language and cognitive processes}, volume = {27}, journal = {Language and cognitive processes}, number = {7-8}, publisher = {Wiley}, address = {Hove}, issn = {0169-0965}, doi = {10.1080/01690965.2011.589735}, pages = {1108 -- 1144}, year = {2012}, abstract = {This study examined the effects of competing speech on auditory semantic comprehension using a dichotic sentence-word priming paradigm. Lexical decision performance for target words presented in spoken sentences was compared in strongly and weakly biasing semantic contexts. Targets were either congruent or incongruent with the sentential bias. Sentences were presented to one auditory channel (right or left), either in isolation or with competing speech produced by a single talker of the same gender presented simultaneously. The competing speech signal was either presented in the same auditory channel as the sentence context, or in a different auditory channel, and was either meaningful (played forward) or unintelligible (time-reversed). Biasing contexts presented in isolation facilitated responses to congruent targets and inhibited responses to incongruent targets, relative to a neutral baseline. Facilitation priming was reduced or eliminated by competing speech presented in the same auditory channel, supporting previous findings that semantic activation is highly sensitive to the intelligibility of the context signal. Competing speech presented in a different auditory channel affected facilitation priming differentially depending upon ear of presentation, suggesting hemispheric differences in the processing of the attended and competing signals. Results were consistent with previous claims of a right ear advantage for meaningful speech, as well as with visual word recognition findings implicating the left hemisphere in the generation of semantic predictions and the right hemisphere in the integration of newly encountered words into the sentence-level meaning. Unlike facilitation priming, inhibition was relatively robust to the energetic and informational masking effects of competing speech and was not influenced by the strength of the contextual bias or the meaningfulness of the competing signal, supporting a two-process model of sentence priming in which inhibition reflects later-stage, expectancy-driven strategic processes that may benefit from perceptual reanalysis after initial semantic activation.}, language = {en} } @article{GoebelXieNeumannetal.2012, author = {Goebel, Ronald and Xie, Zai-Lai and Neumann, Mike and G{\"u}nter, Christina and Loebbicke, Ruben and Kubo, Shiori and Titirici, Maria-Magdalena and Giordano, Cristina and Taubert, Andreas}, title = {Synthesis of mesoporous carbon/iron carbide hybrids with unusually high surface areas from the ionic liquid precursor [Bmim][FeCl4]}, series = {CrystEngComm}, volume = {14}, journal = {CrystEngComm}, number = {15}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1466-8033}, doi = {10.1039/c2ce25064k}, pages = {4946 -- 4951}, year = {2012}, abstract = {Mesoporous carbon/iron carbide hybrid materials with surface areas reaching 800 m(2) g(-1) were synthesized via an exotemplating route using monolithic mesoporous silica as template and the ionic liquid 1-butyl-3-methylimidazolium tetrachloridoferrate(III) [Bmim][FeCl4] as carbon and iron source. After heat treatment (750 degrees C under argon) of the [Bmim][FeCl4] precursor confined within the silica matrix, the silica exotemplate was removed with HF leaving the mesoporous C/Fe3C hybrid behind. The surface areas and the pore sizes depend on the exotemplate and the surface areas a significantly larger than any other surface area reported for C/Fe3C hybrid materials so far. The approach is thus a prototype for the synthesis of high-surface area iron carbide-based hybrid materials with potential application in catalysis.}, language = {en} } @article{WieseFreywaldSchalowskietal.2012, author = {Wiese, Heike and Freywald, Ulrike and Schalowski, Soeren and Mayr, Katharina}, title = {The neighborhood-German corpus spontaneous language data from young urban residential areas}, series = {Deutsche Sprache : ds ; Zeitschrift f{\"u}r Theorie, Praxis, Dokumentation}, volume = {40}, journal = {Deutsche Sprache : ds ; Zeitschrift f{\"u}r Theorie, Praxis, Dokumentation}, number = {2}, publisher = {E. Schmidt}, address = {Berlin}, issn = {0340-9341}, pages = {97 -- 123}, year = {2012}, language = {de} } @article{AdamcikJeonKarczewskietal.2012, author = {Adamcik, Jozef and Jeon, Jae-Hyung and Karczewski, Konrad J. and Metzler, Ralf and Dietler, Giovanni}, title = {Quantifying supercoiling-induced denaturation bubbles in DNA}, series = {Soft matter}, volume = {8}, journal = {Soft matter}, number = {33}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c2sm26089a}, pages = {8651 -- 8658}, year = {2012}, abstract = {In both eukaryotic and prokaryotic DNA sequences of 30-100 base-pairs rich in AT base-pairs have been identified at which the double helix preferentially unwinds. Such DNA unwinding elements are commonly associated with origins for DNA replication and transcription, and with chromosomal matrix attachment regions. Here we present a quantitative study of local DNA unwinding based on extensive single DNA plasmid imaging. We demonstrate that long-lived single-stranded denaturation bubbles exist in negatively supercoiled DNA, at the expense of partial twist release. Remarkably, we observe a linear relation between the degree of supercoiling and the bubble size, in excellent agreement with statistical modelling. Furthermore, we obtain the full distribution of bubble sizes and the opening probabilities at varying salt and temperature conditions. The results presented herein underline the important role of denaturation bubbles in negatively supercoiled DNA for biological processes such as transcription and replication initiation in vivo.}, language = {en} } @inproceedings{KnollWiedemannmHeckhausenetal.2012, author = {Knoll, Nina and Wiedemannm, A. U. and Heckhausen, Juliane and Burkert, Silke and Felber, Juliane and Schrader, M.}, title = {The interplay of autonomy goals and spousal support a prospective study with couples facing cancer}, series = {Psychology \& health : official journal of the European Health Psychology Society}, volume = {27}, booktitle = {Psychology \& health : official journal of the European Health Psychology Society}, number = {33}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0887-0446}, pages = {70 -- 71}, year = {2012}, language = {en} } @article{KammerStarkePietruchaetal.2012, author = {Kammer, Stefan and Starke, Ines and Pietrucha, Andreas and Kelling, Alexandra and Mickler, Wulfhard and Schilde, Uwe and Dosche, Carsten and Kleinpeter, Erich and Holdt, Hans-J{\"u}rgen}, title = {1,12-Diazaperylene and 2,11-dialkylated-1,12-diazaperylene iridium(III) complexes [Ir((CN)-N-boolean AND)(2)((NN)-N-boolean AND)]PF6: new supramolecular assemblies}, series = {Dalton transactions : a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry}, volume = {41}, journal = {Dalton transactions : a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry}, number = {34}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1477-9226}, doi = {10.1039/c2dt30412k}, pages = {10219 -- 10227}, year = {2012}, abstract = {A series of new monocationic iridium(III) complexes [Ir((CN)-N-boolean AND)(2)((NN)-N-boolean AND)]PF6 with "large-surface" alpha,alpha'-diimin ligands (NN)-N-boolean AND (dap = 1,12-diazaperylene, dmedap = 2,11-dimethyl-1,12-diazaperylene, dipdap = 2,11-diisopropyl-1,12-diazaperylene) and different cyclometalating ligands (CN)-N-boolean AND (piq = 1-phenylisoquinoline, bzq = benzo[h]quinoline, ppz = 1-phenylpyrazole, thpy = 2-(2-thienyl)pyridine, ppy = 2-phenylpyridine, meppy = 2-(4-methylphenyl)pyridine, dfppy = 2-(2,4-difluorophenyl)pyridine) were synthesized. The solid structures of the complexes [Ir(piq)(2)(dap)]PF6, [Ir(bzq)(2)(dap)]PF6, [Ir(ppy)(2)(dipdap)]PF6, [Ir(piq)(2)(dmedap)]PF6, [Ir(ppy)(2)(dap)]PF6 and [Ir(ppz)(2)(dap)]PF6 are reported. In [Ir(piq)(2)(dap)]PF6, the dap ligand and one of the piq ligands of each cationic complex are involved in pi-pi stacking interactions forming supramolecular channels running along the crystallographic c axis. In the crystalline [Ir(bzq)(2)(dap)]PF6 pi-pi stacking interactions between the metal complexes lead to the formation of a 2D layer structure. In addition, CH-pi interactions were found in all compounds, which are what stabilizes the solid structure. In particular, a significant number of them were found in [Ir(piq)(2)(dap)]PF6 and [Ir(bzq)(2)(dap)]PF6. The crystal structures of [Ir(ppy)(2)(dipdap)]PF6 and [Ir(ppy)(2)(dmedap)]PF6 are also presented, being the first examples of bis-cyclometalated iridium(III) complexes with phenanthroline-type alpha,alpha'-diimin ligands bearing bulky alkyl groups in the neighbourhood of the N-donor atoms. These ligands implicate a distorted octahedral coordination geometry that in turn destabilized the Ir-N-N boolean AND N bonds. The new iridium (III) complexes are not luminescent. All compounds show an electrochemically irreversible anodic peak between 1.15 and 1.58 V, which is influenced by the different cyclometalated ligands. All of the new complexes show two reversible successive one-electron "large-surface" ligand-centred reductions around -0.70 V and -1.30 V. Electrospray ionisation mass spectrometry (ESI-MS) and collision induced decomposition (CID) measurements were used to investigate the stability of the new complexes. Thereby, the stability agreed well with the order of the Ir-N-N boolean AND N bond lengths.}, language = {en} } @article{DelahayeGoebelLoebbickeetal.2012, author = {Delahaye, Emilie and Goebel, Ronald and Loebbicke, Ruben and Guillot, Regis and Sieber, Christoph and Taubert, Andreas}, title = {Silica ionogels for proton transport}, series = {Journal of materials chemistry}, volume = {22}, journal = {Journal of materials chemistry}, number = {33}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0959-9428}, doi = {10.1039/c2jm00037g}, pages = {17140 -- 17146}, year = {2012}, abstract = {A number of ionogels - silica-ionic liquid (IL) hybrid materials - were synthesized and studied for their ionic conductivity. The materials are based on a sulfonated IL, 1-methyl-3-(3-sulfopropyl-)-imidazolium p-toluenesulfonate, [PmimSO(3)H][PTS], which contains a sulfonic acid/sulfonate group both in the IL anion and in the side chain of the IL cation. By way of the sulfonate-sulfonic acid proton transfer, the IL imparts the ionogel with a high ionic conductivity of ca. 10(-2) S cm(-1) in the as-synthesized state at 120 degrees C and 10(-3) S cm(-1) in the dry state at 120 degrees C. The ionogels are stable up to ca. 150 degrees C in dynamic thermogravimetric analysis. This suggests that these materials, which are relatively cheap and easily fabricated, could find application in fuel cells in intermediate temperature ranges where many other membrane materials are not suitable.}, language = {en} } @inproceedings{KlieglMatuschekHolschneider2012, author = {Kliegl, Reinhold and Matuschek, Hannes and Holschneider, Matthias}, title = {Multivariate analyses of fixation durations in reading with linear mixed and additive mixed models}, series = {International journal of psychology}, volume = {47}, booktitle = {International journal of psychology}, number = {33}, publisher = {Wiley}, address = {Hove}, issn = {0020-7594}, pages = {139 -- 139}, year = {2012}, language = {en} } @inproceedings{Kliegl2012, author = {Kliegl, Reinhold}, title = {Eye movements during reading: Contributions of cross-language comparisons}, series = {International journal of psychology}, volume = {47}, booktitle = {International journal of psychology}, publisher = {Wiley}, address = {Hove}, issn = {0020-7594}, pages = {138 -- 138}, year = {2012}, language = {en} } @article{WulfBookhagenScherler2012, author = {Wulf, Hendrik and Bookhagen, Bodo and Scherler, Dirk}, title = {Climatic and geologic controls on suspended sediment flux in the Sutlej River Valley, western Himalaya}, series = {Hydrology and earth system sciences : HESS}, volume = {16}, journal = {Hydrology and earth system sciences : HESS}, number = {7}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-16-2193-2012}, pages = {2193 -- 2217}, year = {2012}, abstract = {The sediment flux through Himalayan rivers directly impacts water quality and is important for sustaining agriculture as well as maintaining drinking-water and hydropower generation. Despite the recent increase in demand for these resources, little is known about the triggers and sources of extreme sediment flux events, which lower water quality and account for extensive hydropower reservoir filling and turbine abrasion. Here, we present a comprehensive analysis of the spatiotemporal trends in suspended sediment flux based on daily data during the past decade (2001-2009) from four sites along the Sutlej River and from four of its main tributaries. In conjunction with satellite data depicting rainfall and snow cover, air temperature and earthquake records, and field observations, we infer climatic and geologic controls of peak suspended sediment concentration (SSC) events. Our study identifies three key findings: First, peak SSC events (a parts per thousand yen 99th SSC percentile) coincide frequently (57-80\%) with heavy rainstorms and account for about 30\% of the suspended sediment flux in the semi-arid to arid interior of the orogen. Second, we observe an increase of suspended sediment flux from the Tibetan Plateau to the Himalayan Front at mean annual timescales. This sediment-flux gradient suggests that averaged, modern erosion in the western Himalaya is most pronounced at frontal regions, which are characterized by high monsoonal rainfall and thick soil cover. Third, in seven of eight catchments, we find an anticlockwise hysteresis loop of annual sediment flux variations with respect to river discharge, which appears to be related to enhanced glacial sediment evacuation during late summer. Our analysis emphasizes the importance of unconsolidated sediments in the high-elevation sector that can easily be mobilized by hydrometeorological events and higher glacial-meltwater contributions. In future climate change scenarios, including continuous glacial retreat and more frequent monsoonal rainstorms across the Himalaya, we expect an increase in peak SSC events, which will decrease the water quality and impact hydropower generation.}, language = {en} } @article{BangHoviSprinz2012, author = {Bang, Guri and Hovi, Jon and Sprinz, Detlef F.}, title = {US presidents and the failure to ratify multilateral environmental agreements}, series = {Climate policy}, volume = {12}, journal = {Climate policy}, number = {6}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1469-3062}, doi = {10.1080/14693062.2012.699788}, pages = {755 -- 763}, year = {2012}, abstract = {Whereas the US President signed the Kyoto Protocol, the failure of the US Congress to ratify it seriously hampered subsequent international climate cooperation. This recent US trend, of signing environmental treaties but failing to ratify them, could thwart attempts to come to a future climate agreement. Two complementary explanations of this trend are proposed. First, the political system of the US has distinct institutional features that make it difficult for presidents to predict whether the Senate will give its advice and consent to multilateral environmental agreements (MEAs) and whether Congress will pass the required enabling legislation. Second, elected for a fixed term, US presidents might benefit politically from supporting MEAs even when knowing that legislative support is not forthcoming. Four policy implications are explored, concerning the scope for unilateral presidential action, the potential for bipartisan congressional support, the effectiveness of a treaty without the US, and the prospects for a deep, new climate treaty. Policy relevance Why does the failure of US ratification of multilateral environmental treaties occur? This article analyses the domestic political mechanisms involved in cases of failed US ratification. US non-participation in global environmental institutions often has serious ramifications. For example, it sharply limited Kyoto's effectiveness and seriously hampered international climate negotiations for years. Although at COP 17 in Durban the parties agreed to negotiate a new agreement by 2015, a new global climate treaty may well trigger a situation resembling the one President Clinton faced in 1997 when he signed Kyoto but never obtained support for it in the Senate. US failure to ratify could thwart future climate agreements.}, language = {en} } @misc{Zerbian2012, author = {Zerbian, Sabine}, title = {Variation in the grammar of black south African English}, series = {Southern African linguistics and applied language studies}, volume = {30}, journal = {Southern African linguistics and applied language studies}, number = {1}, publisher = {NISC}, address = {Grahamstown}, issn = {1607-3614}, doi = {10.2989/16073614.2012.693721}, pages = {131 -- 135}, year = {2012}, language = {en} } @article{BluethgenDormannPratietal.2012, author = {Bl{\"u}thgen, Nico and Dormann, Carsten F. and Prati, Daniel and Klaus, Valentin H. and Kleinebecker, Till and Hoelzel, Norbert and Alt, Fabian and Boch, Steffen and Gockel, Sonja and Hemp, Andreas and M{\"u}ller, J{\"o}rg and Nieschulze, Jens and Renner, Swen C. and Sch{\"o}ning, Ingo and Schumacher, Uta and Socher, Stephanie A. and Wells, Konstans and Birkhofer, Klaus and Buscot, Francois and Oelmann, Yvonne and Rothenw{\"o}hrer, Christoph and Scherber, Christoph and Tscharntke, Teja and Weiner, Christiane N. and Fischer, Markus and Kalko, Elisabeth K. V. and Linsenmair, Karl Eduard and Schulze, Ernst-Detlef and Weisser, Wolfgang W.}, title = {A quantitative index of land-use intensity in grasslands integrating mowing, grazing and fertilization}, series = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie}, volume = {13}, journal = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie}, number = {3}, publisher = {Elsevier}, address = {Jena}, issn = {1439-1791}, doi = {10.1016/j.baae.2012.04.001}, pages = {207 -- 220}, year = {2012}, abstract = {Land use is increasingly recognized as a major driver of biodiversity and ecosystem functioning in many current research projects. In grasslands, land use is often classified by categorical descriptors such as pastures versus meadows or fertilized versus unfertilized sites. However, to account for the quantitative variation of multiple land-use types in heterogeneous landscapes, a quantitative, continuous index of land-use intensity (LUI) is desirable. Here we define such a compound, additive LUI index for managed grasslands including meadows and pastures. The LUI index summarizes the standardized intensity of three components of land use, namely fertilization, mowing, and livestock grazing at each site. We examined the performance of the LUI index to predict selected response variables on up to 150 grassland sites in the Biodiversity Exploratories in three regions in Germany(Alb, Hainich, Schorlheide). We tested the average Ellenberg nitrogen indicator values of the plant community, nitrogen and phosphorus concentration in the aboveground plant biomass, plant-available phosphorus concentration in the top soil, and soil C/N ratio, and the first principle component of these five response variables. The LUI index significantly predicted the principal component of all five response variables, as well as some of the individual responses. Moreover, vascular plant diversity decreased significantly with LUI in two regions (Alb and Hainich). Inter-annual changes in management practice were pronounced from 2006 to 2008, particularly due to variation in grazing intensity. This rendered the selection of the appropriate reference year(s) an important decision for analyses of land-use effects, whereas details in the standardization of the index were of minor importance. We also tested several alternative calculations of a LUI index, but all are strongly linearly correlated to the proposed index. The proposed LUI index reduces the complexity of agricultural practices to a single dimension and may serve as a baseline to test how different groups of organisms and processes respond to land use. In combination with more detailed analyses, this index may help to unravel whether and how land-use intensities, associated disturbance levels or other local or regional influences drive ecological processes.}, language = {en} } @article{Dornick2012, author = {Dornick, Sahra}, title = {"Footnotes to the Family" Performativity to the trauma of the Holocaust in the German-Jewish Family novels "So are we" (Gila Lustiger) and "Family Life" (Viola Roggenkamp)}, series = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, volume = {64}, journal = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, number = {2}, publisher = {Brill}, address = {Leiden}, issn = {0044-3441}, pages = {138 -- 151}, year = {2012}, language = {de} } @article{BaumgartnerLesevicKumarietal.2012, author = {Baumgartner, Jens and Lesevic, Paul and Kumari, Monika and Halbmair, Karin and Bennet, Mathieu and Koernig, Andre and Widdrat, Marc and Andert, Janet and Wollgarten, Markus and Bertinetti, Luca and Strauch, Peter and Hirt, Ann and Faivre, Damien}, title = {From magnetotactic bacteria to hollow spirilla-shaped silica containing a magnetic chain}, series = {RSC Advances}, volume = {2}, journal = {RSC Advances}, number = {21}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2046-2069}, doi = {10.1039/c2ra20911j}, pages = {8007 -- 8009}, year = {2012}, abstract = {Magnetotactic bacteria produce chains of magnetite nanoparticles, which are called magnetosomes and are used for navigational purposes. We use these cells as a biological template to prepare a hollow hybrid material based on silica and magnetite, and show that the synthetic route is nondestructive as the material conserves the cell morphology as well as the alignment of the magnetic particles. The hybrid material can be resuspended in aqueous solution, and can be shown to orient itself in an external magnetic field. We anticipate that chemical modification of the silica can be used to functionalize the material surface in order to obtain multifunctional materials with specialized applications, e.g. targeted drug delivery.}, language = {en} } @article{SemmoHildebrandtTrappetal.2012, author = {Semmo, Amir and Hildebrandt, Dieter and Trapp, Matthias and D{\"o}llner, J{\"u}rgen Roland Friedrich}, title = {Concepts for cartography-oriented visualization of virtual 3D city models}, series = {Photogrammetrie, Fernerkundung, Geoinformation}, journal = {Photogrammetrie, Fernerkundung, Geoinformation}, number = {4}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {1432-8364}, doi = {10.1127/1432-8364/2012/0131}, pages = {455 -- 465}, year = {2012}, abstract = {Virtual 3D city models serve as an effective medium with manifold applications in geoinformation systems and services. To date, most 3D city models are visualized using photorealistic graphics. But an effective communication of geoinformation significantly depends on how important information is designed and cognitively processed in the given application context. One possibility to visually emphasize important information is based on non-photorealistic rendering, which comprehends artistic depiction styles and is characterized by its expressiveness and communication aspects. However, a direct application of non-photorealistic rendering techniques primarily results in monotonic visualization that lacks cartographic design aspects. In this work, we present concepts for cartography-oriented visualization of virtual 3D city models. These are based on coupling non-photorealistic rendering techniques and semantics-based information for a user, context, and media-dependent representation of thematic information. This work highlights challenges for cartography-oriented visualization of 3D geovirtual environments, presents stylization techniques and discusses their applications and ideas for a standardized visualization. In particular, the presented concepts enable a real-time and dynamic visualization of thematic geoinformation.}, language = {en} } @article{ZhuKolloscheLuetal.2012, author = {Zhu, Jian and Kollosche, Matthias and Lu, Tongqing and Kofod, Guggi and Suo, Zhigang}, title = {Two types of transitions to wrinkles in dielectric elastomers}, series = {Soft matter}, volume = {8}, journal = {Soft matter}, number = {34}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c2sm26034d}, pages = {8840 -- 8846}, year = {2012}, abstract = {A membrane of a dielectric elastomer coated with compliant electrodes may form wrinkles as the applied voltage is ramped up. We present a combination of experiment and theory to investigate the transition to wrinkles using a clamped membrane subject to a constant force and a voltage ramp. Two types of transitions are identified. In type-I transition, the voltage-stretch curve is N-shaped, and flat and wrinkled regions coexist in separate areas of the membrane. The type-I transition progresses by nucleation of small wrinkled regions, followed by the growth of the wrinkled regions at the expense of the flat regions, until the entire membrane is wrinkled. By contrast, in type-II transition, the voltage-stretch curve is monotonic, and the entire flat membrane becomes wrinkled with no nucleation barrier. The two types of transitions are analogous to the first and the second order phase transitions. While the type-I transition is accompanied by a jump in the vertical displacement, type-II transition is accompanied by a continuous change in the vertical displacement. Such transitions may enable applications in muscle-like actuation and energy harvesting, where large deformation and large energy of conversion are desired.}, language = {en} } @article{WendeWojtkiewiczMarschalletal.2012, author = {Wende, Wolfgang and Wojtkiewicz, Wera and Marschall, Ilke and Heiland, Stefan and Lipp, Torsten and Reinke, Markus and Schaal, Peter and Schmidt, Catrin}, title = {Putting the plan into practice implementation of proposals for measures of local landscape plans}, series = {Landscape research}, volume = {37}, journal = {Landscape research}, number = {4}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0142-6397}, doi = {10.1080/01426397.2011.592575}, pages = {483 -- 500}, year = {2012}, abstract = {The knowledge of the effectiveness of local landscape planning in Germany is in the main limited to particular cases and derives mostly from qualitative single case studies. This applies especially to the implementation of measures defined by landscape plans. To fill that gap, the paper focuses on the implementation of those measures. Furthermore, it discusses the factors and framework conditions which are crucial for this implementation. The potential factors and conditions of influence were derived from theory and compiled in 20 investigation hypotheses. In order to gain information on the execution of the measures, 28 randomly selected plans were first analysed, then interviews were carried out with administration representatives. It can be stated that landscape planning has positively influenced the development of nature and landscape in the investigated municipalities. A considerable number of measures had been implemented, although landscape planning as a supply-side instrument proposes generally a very large number of measures. Factors with a positive effect on the implementation of landscape planning measures are pointed out.}, language = {en} } @article{LemkeKoetz2012, author = {Lemke, Karina and Koetz, Joachim}, title = {Polycation-capped CdS quantum dots synthesized in reverse microemulsions}, series = {Journal of nanomaterials}, journal = {Journal of nanomaterials}, number = {4}, publisher = {Hindawi Publishing Corp.}, address = {New York}, issn = {1687-4110}, doi = {10.1155/2012/478153}, pages = {10}, year = {2012}, abstract = {This paper is focused on the formation and recovery of cadmium sulfide (CdS) nanoparticles in two different types of polycation-modified reverse microemulsions using low molecular weight poly(diallyldimethylammonium chloride) (PDADMAC) and poly(ethyleneimine) (PEI). Both polymers were incorporated in a quaternary w/o microemulsion consisting of water, toluene-pentanol (1 : 1), and sodium dodecyl sulfate (SDS), as well as in a ternary w/o microemulsion consisting of water, heptanol, and 3( N,N-dimethyl-dodecylammonio)-propanesulfonate (SB). UV-vis and fluorescence measurements in the microemulsion illustrate the capping effect of the polycations on the formation of the CdS quantum dots. The nanoparticles are redispersed in water and characterized by using UV-vis and fluorescence spectroscopy, in combination with dynamic light scattering. From the quaternary microemulsion, only nanoparticle aggregates of about 100 nm can be redispersed, but, from the ternary microemulsion, well-stabilized polycation-capped CdS quantum dots can be obtained. The results show that the electrostatic interactions between the polycation and the surfactant are of high relevance especially in the solvent evaporation and redispersion process. That means only that in the case of moderate polycation-surfactant interactions a redispersion of the polymer-capped CdS quantum dots without problems of aggregation is possible.}, language = {en} } @unpublished{WannickeEndresEngeletal.2012, author = {Wannicke, Nicola and Endres, S. and Engel, A. and Grossart, Hans-Peter and Nausch, M. and Unger, J. and Voss, Martin}, title = {Response of nodularia spumigena to pCO(2) - Part 1: Growth, production and nitrogen cycling}, series = {Biogeosciences}, volume = {9}, journal = {Biogeosciences}, number = {8}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-9-2973-2012}, pages = {2973 -- 2988}, year = {2012}, abstract = {Heterocystous cyanobacteria of the genus Nodularia form extensive blooms in the Baltic Sea and contribute substantially to the total annual primary production. Moreover, they dispense a large fraction of new nitrogen to the ecosystem when inorganic nitrogen concentration in summer is low. Thus, it is of ecological importance to know how Nodularia will react to future environmental changes, in particular to increasing carbon dioxide (CO2) concentrations and what consequences there might arise for cycling of organic matter in the Baltic Sea. Here, we determined carbon (C) and dinitrogen (N-2) fixation rates, growth, elemental stoichiometry of particulate organic matter and nitrogen turnover in batch cultures of the heterocystous cyanobacterium Nodularia spumigena under low (median 315 mu atm), mid (median 353 mu atm), and high (median 548 mu atm) CO2 concentrations. Our results demonstrate an overall stimulating effect of rising pCO(2) on C and N-2 fixation, as well as on cell growth. An increase in pCO(2) during incubation days 0 to 9 resulted in an elevation in growth rate by 84 +/- 38\% (low vs. high pCO(2)) and 40 +/- 25\% (mid vs. high pCO(2)), as well as in N-2 fixation by 93 +/- 35\% and 38 +/- 1\%, respectively. C uptake rates showed high standard deviations within treatments and in between sampling days. Nevertheless, C fixation in the high pCO(2) treatment was elevated compared to the other two treatments by 97\% (high vs. low) and 44\% (high vs. mid) at day 0 and day 3, but this effect diminished afterwards. Additionally, elevation in carbon to nitrogen and nitrogen to phosphorus ratios of the particulate biomass formed (POC : POP and PON : POP) was observed at high pCO(2). Our findings suggest that rising pCO(2) stimulates the growth of heterocystous diazotrophic cyanobacteria, in a similar way as reported for the non-heterocystous diazotroph Trichodesmium. Implications for biogeochemical cycling and food web dynamics, as well as ecological and socio-economical aspects in the Baltic Sea are discussed.}, language = {en} } @article{Winst2012, author = {Winst, Silke}, title = {Narration in the late middle ages seriality and complexity in the epic prose "Loher and Maller"}, series = {Beitr{\"a}ge zur Geschichte der deutschen Sprache und Literatur}, volume = {134}, journal = {Beitr{\"a}ge zur Geschichte der deutschen Sprache und Literatur}, number = {2}, publisher = {Niemeyer}, address = {T{\"u}bingen}, issn = {0005-8076}, pages = {220 -- 238}, year = {2012}, language = {de} } @article{RisseKussmaulKruegeretal.2012, author = {Risse, Sebastian and Kussmaul, Bj{\"o}rn and Kr{\"u}ger, Hartmut and Kofod, Guggi}, title = {A versatile method for enhancement of electromechanical sensitivity of silicone elastomers}, series = {RSC Advances}, volume = {2}, journal = {RSC Advances}, number = {24}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2046-2069}, doi = {10.1039/c2ra21541a}, pages = {9029 -- 9035}, year = {2012}, abstract = {Dielectric elastomer actuators (DEAs) draw their function from their dielectric and mechanical properties. The paper describes the fabrication and various properties of molecularly grafted silicone elastomer films. This was achieved by addition of high-dipole molecular co-substituents to off-the-shelf silicone elastomer kits, Elastosil RT 625 and Sylgard 184 by Wacker and Dow Corning, respectively. Strong push-pull dipoles were chemically grafted to both polymer networks during a one step film formation process. All manufactured films were characterized using (13) C-NMR and FT-IR spectroscopy, confirming a successful attachment of the dipoles to the silicone network. Differential scanning calorimetry (DSC) results showed that grafted dipoles were distributed homogeneously throughout the material avoiding the formation of nano-scale aggregates. The permittivity increased with the amount of dipole at all frequencies, while the Young's modulus and electrical breakdown strength were reduced. Actuation strain measurements in the pure shear configuration independently confirmed the increase in electromechanical sensitivity. The ability to enhance electromechanical properties of off-the-shelf materials could strongly expand the range of actuator properties available to researchers and end-users.}, language = {en} } @article{ShainyanKirpichenkoKleinpeter2012, author = {Shainyan, Bagrat A. and Kirpichenko, Svetlana V. and Kleinpeter, Erich}, title = {Synthesis and conformational properties of 1,3-dimethyl-3-phenyl-1,3-azasilinane low temperature dynamic NMR and computational study}, series = {Arkivoc : free online journal of organic chemistry}, journal = {Arkivoc : free online journal of organic chemistry}, number = {24}, publisher = {ARKAT}, address = {Gainesville}, issn = {1551-7004}, pages = {175 -- 185}, year = {2012}, abstract = {1,3-Dimethyl-3-phenyl-1,3-azasilinane was synthesized and its conformational behavior was studied by the low temperature NMR spectroscopy and quantum chemical calculations. The compound was shown to exist as an equilibrium mixture of the PhaxMeeq and PheqMeax chair conformers with the N-methyl substituent in equatorial position. The barrier to ring inversion was also determined.}, language = {en} } @article{KleinpeterKoch2012, author = {Kleinpeter, Erich and Koch, Andreas}, title = {Spatial magnetic properties subject to lone pair and pi electron delocalization in benzenoid and quinoid structures are quinoid tautomers really nonaromatic?}, series = {Arkivoc : free online journal of organic chemistry}, journal = {Arkivoc : free online journal of organic chemistry}, publisher = {ARKAT}, address = {Gainesville}, issn = {1551-7004}, pages = {94 -- 108}, year = {2012}, abstract = {The spatial magnetic properties, through-space NMR shieldings (TSNMRS), of benzenoid and quinoid tautomeric structures such as benzodifurantrione and phenazine-type molecules have been calculated using the GIAO perturbation method employing the nucleus independent chemical shift (NICS) concept of Paul von Rague Schleyer and visualized as iso-chemical-shielding surfaces (ICSS) of various size and direction. The TSNMRS values were employed to quantify and visualize the partial aromaticity of the studied compounds. In the case of the surprisingly more stable quinoid tautomers, the aromaticity-synonymous with stability due to the conjugation of p electrons and lone pairs-was not found to be particularly reduced.}, language = {en} } @misc{PihlajaKleinpeter2012, author = {Pihlaja, Kalevi and Kleinpeter, Erich}, title = {Professor Ferenc Fulop a tribute}, series = {Arkivoc : free online journal of organic chemistry}, journal = {Arkivoc : free online journal of organic chemistry}, publisher = {ARKAT}, address = {Gainesville}, issn = {1551-7004}, pages = {1 -- 5}, year = {2012}, language = {en} } @article{JacksonSorge2012, author = {Jackson, Gregory and Sorge, Arndt}, title = {The trajectory of institutional change in Germany, 1979-2009}, series = {Journal of European public policy}, volume = {19}, journal = {Journal of European public policy}, number = {8}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1350-1763}, doi = {10.1080/13501763.2012.709009}, pages = {1146 -- 1167}, year = {2012}, abstract = {Over the last three decades, the German political economy can be characterized by both institutional continuity and change. Understanding the dynamics of institutional change therefore requires an examination of the interplay of changes in formal institutional rules and how organizations respond to these changes by strategic attempts to promote or hinder further change in institutions. The macro-level political story of institutional change shows a number of paradoxes resulting in unexpected and often incomplete forms of market liberalization shaped by continued support for some core features of Germany's social market economy. The resulting erosion of Germany's co-ordinated model of economic organization through networks and business associations has gone hand-in-hand with the attempts to preserve these institutions for core workers and sectors of the economy in the face of changing environments. The result is a more varied institutional landscape characterized by international diffusion of liberal policies and the politics of their variable re-embedding within a long-term path of institutional continuity.}, language = {en} } @article{NajafpourHillierShamkhalietal.2012, author = {Najafpour, Mohammad Mahdi and Hillier, Warwick and Shamkhali, Amir Nasser and Amini, Mojtaba and Beckmann, Katrin and Jaglicic, Zvonko and Jagodic, Marko and Strauch, Peter and Moghaddam, Atefeh Nemati and Beretta, Giangiacomo and Bagherzadeh, Mojtaba}, title = {Synthesis, characterization, DFT studies and catalytic activities of manganese(II) complex with 1,4-bis(2,2 ':6,2 ''-terpyridin-4 '-yl) benzene}, series = {Dalton transactions : a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry}, volume = {41}, journal = {Dalton transactions : a journal of inorganic chemistry, including bioinorganic, organometallic, and solid-state chemistry}, number = {39}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1477-9226}, doi = {10.1039/c2dt31544k}, pages = {12282 -- 12288}, year = {2012}, abstract = {A new di-manganese complex with "back-to-back" 1,4-bis(2,2':6,2 ''-terpyridin-4'-yl) benzene ligation has been synthesized and characterised by a variety of techniques. The back-to-back ligation presents a novel new mononuclear manganese catalytic centre that functions as a heterogeneous catalysis for the evolution of oxygen in the presence of an exogenous oxidant. We discuss the synthesis and spectroscopic characterizations of this complex and propose a mechanism for oxygen evolution activity of the compound in the presence of oxone. The di-manganese complex also shows efficient and selective catalytic oxidation of sulfides in the presence of H2O2. Density functional theory calculations were used to assess the structural optimization of the complex and a proposed reaction pathway with oxone. The calculations show that middle benzene ring is distorted respect to both of metallic centers, and this in turn leads to negligible resonance of electrons between two sides of complex. The calculations also indicate the unpaired electron located on oxyl-ligand emphasizes the radical mechanism of water oxidation for the system.}, language = {en} } @article{HocherGroenSchumannetal.2012, author = {Hocher, Berthold and Groen, Hans J{\"u}rgen and Schumann, Claudia and Tsuprykov, Oleg and Seifert, Susanne and Hitzler, Walter E. and Armbruster, Franz Paul}, title = {Vitamin D status from dried capillary blood samples}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {7-8}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2012.120429}, pages = {851 -- 855}, year = {2012}, abstract = {Background: Given the huge impact of vitamin D deficiency on a broad spectrum of diseases such as rickets, osteoporosis, mineral bone disease-vascular calcification syndrome, infectious diseases, but also several types of cancer and CNS diseases, reliable and simple methods to analyze the vitamin D status are urgently needed. Methods: We developed an easy technique to determine the 25-OH vitamin D status from dried blood samples on filter paper. This allows determination of the 25-OH vitamin D status independently of venous blood taking, since only sampling of capillary blood is required for this new method. We compared the results of vitamin D measurements from venous blood of 96 healthy blood donors with those from capillary blood taken from the same patients at the same time. The capillary blood was dried on filter paper using the D-Vital ID dry-blood collection system. Results: 25-OH vitamin D concentration data from extracted dried capillary blood filters correlated very well with data obtained after direct measurement of venous blood samples of the same blood donor (R: 0.7936; p<0.0001). The correlation was linear over the whole range of 25-OH vitamin D concentrations seen in this study. A Bland-Altman plot revealed good agreement between both tests. Conclusions: The D-Vital ID dry-blood collection system showed an excellent performance as compared to the classical way of 25-OH vitamin D measurement from venous blood. This new technique will facilitate easy and reliable measurement for vitamin D status, in particular, in rural or isolated areas, developing countries, and field studies.}, language = {en} } @article{VickersCheethamBirminghametal.2012, author = {Vickers, Steven P. and Cheetham, Sharon C. and Birmingham, Gareth D. and Rowley, Helen L. and Headland, Katie R. and Dickinson, Keith and Grempler, Rolf and Hocher, Berthold and Mark, Michael and Klein, Thomas}, title = {Effects of the DPP-4 Inhibitor, Linagliptin, in Diet-Induced obese rats a comparison in Naive and Exenatide-Treated Animals}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {7-8}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2011.110919}, pages = {787 -- 799}, year = {2012}, abstract = {Background: To assess the chronic effect of the DPP-4 inhibitor, linagliptin, alone, in combination with exenatide, and during exenatide withdrawal, in diet-induced obese (DIO) rats. Methods: Female Wistar rats were exposed to a cafeteria diet to induce obesity. Animals were then dosed with vehicle or linagliptin (3 mg/kg PO) orally once-daily for a 28 day period. In a subsequent study, rats received exenatide (either 3 or 30 mu g/kg/day) or vehicle by osmotic mini-pump for 28 days. In addition, groups of animals were dosed orally with linagliptin either alone or in combination with a 3 mu g/kg/day exenatide dose for the study duration. In a final study, rats were administered exenatide (30 mu g/kg/day) or vehicle by osmotic mini-pump for eleven days. Subsequently, exenatide-treated animals were transferred to vehicle or continued exenatide infusion for a further ten days. Animals transferred from exenatide to vehicle were also dosed orally with either vehicle or linagliptin. In all studies, body weight, food and water intake were recorded daily and relevant plasma parameters and carcass composition were determined. Results: In contrast to exenatide, linagliptin did not significantly reduce body weight or carcass fat in DIO rats versus controls. Linagliptin augmented the effect of exenatide to reduce body fat when given in combination but did not affect the body weight response. In rats withdrawn from exenatide, weight regain was observed such that body weight was not significantly different to controls. Linagliptin reduced weight regain after withdrawal of exenatide such that a significant difference from controls was evident. Conclusions: These data demonstrate that linagliptin does not significantly alter body weight in either untreated or exenatide-treated DIO rats, although it delays weight gain after exenatide withdrawal. This finding may suggest the utility of DPP-4 inhibitors in reducing body weight during periods of weight gain.}, language = {en} } @article{AlterKretschmerVonWebskyetal.2012, author = {Alter, Markus L. and Kretschmer, Axel and Von Websky, Karoline and Tsuprykov, Oleg and Reichetzeder, Christoph and Simon, Alexandra and Stasch, Johannes-Peter and Hocher, Berthold}, title = {Early urinary and plasma biomarkers for experimental diabetic Nephropathy}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {7-8}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2011.111010}, pages = {659 -- 671}, year = {2012}, abstract = {Background: As the prevalence of diabetes rises, its complications such as diabetic nephropathy affect an increaseing number of patients. Consequently, the need for biomarkers in rodent models which reflect the stage and course of diabetic nephropathy is high. This article focuses on Heart-type fatty acid binding protein (H-FABP), osteopontin (OPN), nephrin, and Neutrophil gelatinase-associated lipocalin (NGAL) in urine, and kidney injury molecule (KIM)-1, clusterin, and tissue inhibitior of metalloproteinases (TIMP) 1 in plasma in uni-nephrectomized rats with streptocotozin-induced type 1 diabetes mellitus, a common animal model to explore renal impairment in the setting of diabetes mellitus. Methods: 23 male Wistar rats were uni-nephrectomized and subsequently divided into two study groups. The diabetic group received streptozotocin (STZ) via tail-vein injection, the non-diabetic group received citrate buffer without STZ. Subsequently, blood glucose, body weight, and blood pressure were checked regularly. After 18 weeks, animals were placed in metabolic cages, blood and urine obtained and subsequently organs were harvested after sacrifice. Results: Blood glucose levels were highly increased in diabetic animals throughout the experiment, whereas systolic blood pressure did not differ between the study groups. At study end, classical biomarkers such as urinary albumin and protein and plasma cystatin c were only slightly but not significantly different between groups indicating a very early disease state. In contrast, urinary excretion of H-FABP, OPN, nephrin, and NGAL were highly increased in diabetic animals with a highly significant p-value (p<0.01 each) compared to non-diabetic animals. In plasma, differences were found for calbindin, KIM-1, clusterin, TIMP-1, and OPN. These findings were confirmed by means of the area under the receiver operating characteristic curve (ROC-AUC) analysis. Conclusions: In summary, our study revealed elevated levels of new plasma and urinary biomarkers (urinary osteopontin, urinary nephrin, urinary NGAL, urinary H-FABP, plasma KIM-1, plasma TIMP-1) in uni-nephrectomized diabetic rats, an established rat model of diabetic nephropathy. These biomarkers appeared even before the classical biomarkers of diabetic nephropathy such as albuminuria and urinary protein excretion. The new biomarkers might offer advantage to urinary albumin and plasma cystatin c with respect to early detection.}, language = {en} } @article{SchmerbachKalkWengenmayeretal.2012, author = {Schmerbach, K. and Kalk, Philipp. and Wengenmayer, Christina and Lucht, K. and Unger, T. and Hocher, Berthold and Thoene-Reineke, C.}, title = {Renal outcome in equipotent Antihypertensive Treatment with Telmisartan, Ramipril and in combination in SHR-SP Rats}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {7-8}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2011.110622}, pages = {625 -- 633}, year = {2012}, abstract = {Background: The ONTARGET trial revealed an association of ACEI/ARB combination treatment (telmisartan and ramipril) with adverse renal outcome versus respective monotherapy; preclinical evidence regarding renal outcome in ACEI/ARB combination treatment is scarce. Methods: Spontaneously hypertensive stroke prone rats (SHR-SP) rats on a salt-rich diet were randomly allocated to 4 groups: SHR (untreated, n = 24), SHR + telmisartan (SHR-T, 2.39 +/- 0.69 mg/kg bw; n = 27), SHR + ramipril (SHR-R, 6.28 +/- 3.48 mg/kg bw; n = 27) and combination treatment (SHR-TR, 0.51 +/- 0.14 mg/kg bw; same dose for telmisartan and ramipril; n = 26). Study duration was 12 weeks, blood pressure was assessed weekly and doses were adjusted to maintain equal blood pressure. Finally, blood and urine samples were obtained and kidneys were harvested for histological studies. Results: Blood pressure in untreated rats rose to a maximum of 239 mmHg, whereas in all treatment groups it remained stable betvveen 140 and 150 mmHg. Mortality was 50\% in the untreated group, whereas all treatment groups survived completely. Renal function - as indicated by plasma urea and cystatin c - was significantly worse in SHR-TR animals compared to all other groups. With plasma creatinine a similar trend was observed. All treatment options significantly decreased albuminuria. Renal glomerulosclerosis was decreased by monotherapy, whereas combination therapy failed to have a significant effect. Interstitial fibrosis was decreased to a similar extent by all treatment options. Conclusions: ACEI/ARB combination treatment failed to render significant additional benefits on renal outcome in hypertensive rats when compared to monotherapy. Instead our data indicate that dual RAAS blockade might have an adverse effect on kidney function and histology when compared to monotherapy in salt-loaded SHR-SP.}, language = {en} } @article{TiseanuCojocaruParvulescuetal.2012, author = {Tiseanu, Carmen and Cojocaru, Bogdan and Parvulescu, Vasile I. and Sanchez-Dominguez, Margarita and Primus, Philipp A. and Boutonnet, Magali}, title = {Order and disorder effects in nano-ZrO2 investigated by micro-Raman and spectrally and temporarily resolved photoluminescence}, series = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, volume = {14}, journal = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, number = {37}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/c2cp41946g}, pages = {12970 -- 12981}, year = {2012}, abstract = {Pure and europium (Eu3+) doped ZrO2 synthesized by an oil-in-water microemulsion reaction method were investigated by in situ and ex situ X-ray diffraction (XRD), ex situ Raman spectroscopy, high-resolution transmission electron microscopy (HRTEM), steady state and time-resolved photoluminescence (PL) spectroscopies. Based on the Raman spectra excited at three different wavelengths i.e. 488, 514 and 633 nm and measured in the spectral range of 150-4000 cm(-1) the correlation between the phonon spectra of ZrO2 and luminescence of europium is clearly evidenced. The PL investigations span a variety of steady-state and time resolved measurements recorded either after direct excitation of the Eu3+ f-f transitions or indirect excitation into UV charge-transfer bands. After annealing at 500 degrees C, the overall Eu3+ emission is dominated by Eu3+ located in tetragonal symmetry lattice sites with a crystal-field splitting of the D-5(0)-F-7(1) emission of 20 cm(-1). Annealing of ZrO2 at 1000 degrees C leads to a superposition of Eu3+ emissions from tetragonal and monoclinic lattice sites with monoclinic crystal-field splitting of 200 cm(-1) for the D-5(0)-F-7(1) transition. At all temperatures, a non-negligible amorphous/disordered content is also measured and determined to be of monoclinic nature. It was found that the evolutions with calcination temperature of the average PL lifetimes corresponding to europium emission in the tetragonal and monoclinic sites and the monoclinic phase content of the Eu3+ doped ZrO2 samples follow a similar trend. By use of specific excitation conditions, the distribution of europium on the amorphous/disordered surface or ordered/crystalline sites can be identified and related to the phase content of zirconia. The role of zirconia host as a sensitizer for the europium PL is also discussed in both tetragonal and monoclinic phases.}, language = {en} } @article{Albertini2012, author = {Albertini, Francesca Yardenit}, title = {Peace and war in Moses Maimonides and Immanuel Kant a comparative study}, series = {The journal of Jewish thought \& philosophy}, volume = {20}, journal = {The journal of Jewish thought \& philosophy}, number = {2}, publisher = {Brill}, address = {Leiden}, issn = {1053-699X}, doi = {10.1163/1477285X-12341238}, pages = {183 -- 198}, year = {2012}, abstract = {Francesca Y. Albertini (1974-2011) compares Maimonides' idea of peace, as developed in MT Sefer shofetim (Book of Judges), with Kant's work on the notion of "eternal peace" (Zum ewigen Frieden). Both authors develop a historical vision pointed against the use of force and war in light of a framework not limited by historical time (messianic age, eternity). Despite all differences in method and historical context, the authors agree on the notion that universal ethics provides the basis of a determination of right grounded in the will. Maimonides' universal messianism as well as Kant's universal history emphasize the pivotal role and decisive responsibility of the human being in realizing, through reason, the reign of peace and prosperity on earth first envisioned by the biblical prophets. These utopias continue to challenge us, especially in this day and age.}, language = {en} } @misc{Juchler2012, author = {Juchler, Ingo}, title = {Critical political Education a guidebook}, series = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, volume = {53}, journal = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, number = {1}, publisher = {Nomos}, address = {Hannover}, issn = {0032-3470}, pages = {162 -- 164}, year = {2012}, language = {de} } @article{Koss2012, author = {Koss, Michael}, title = {The determinants of parliamentary agenda powers a holistic framework for analysing parliamentary change}, series = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, volume = {53}, journal = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, number = {1}, publisher = {Nomos}, address = {Hannover}, issn = {0032-3470}, pages = {29 -- 52}, year = {2012}, abstract = {This article calls for a holistic perspective on parliamentary change through the analytical lens of parliamentary agenda powers. In addition to agenda control, the concept of agenda powers not only refers to the ability of parliamentary actors to directly influence parliamentary output through legislation (efficiency), but also to exert indirect influence through controlling the government (effectiveness) and through affecting public opinion (legitimacy). The concept of agenda powers comprises the formal institutional rules underlying the distribution of the parliamentary agenda, the factual application of these rules and the organisational powers enabling actors to make use of their time. The distribution of agenda powers can be explained by the sequencing of legitimacy, effectiveness, and efficiency reforms. Consequently, the concept of parliamentary agenda powers allows for a comparative long-term analysis of parliamentary change. Furthermore, the concept of parliamentary agenda powers enables us to operationalise normative scenarios of a de-parliamentarisation and the alleged transitions towards post- or neo-parliamentarian democracy.}, language = {de} } @misc{SachseBillaultBowenetal.2012, author = {Sachse, Dirk and Billault, Isabelle and Bowen, Gabriel J. and Chikaraishi, Yoshito and Dawson, Todd E. and Feakins, Sarah J. and Freeman, Katherine H. and Magill, Clayton R. and McInerney, Francesca A. and van der Meer, Marcel T. J. and Polissar, Pratigya and Robins, Richard J. and Sachs, Julian P. and Schmidt, Hanns-Ludwig and Sessions, Alex L. and White, James W. C. and West, Jason B. and Kahmen, Ansgar}, title = {Molecular Paleohydrology interpreting the Hydrogen- Isotopic Composition of Lipid Biomarkers from Photosynthesizing Organisms}, series = {Annual review of earth and planetary sciences}, volume = {40}, journal = {Annual review of earth and planetary sciences}, number = {1}, editor = {Jeanloz, R}, publisher = {Annual Reviews}, address = {Palo Alto}, isbn = {978-0-8243-2040-9}, issn = {0084-6597}, doi = {10.1146/annurev-earth-042711-105535}, pages = {221 -- 249}, year = {2012}, abstract = {Hydrogen-isotopic abundances of lipid biomarkers are emerging as important proxies in the study of ancient environments and ecosystems. A decade ago, pioneering studies made use of new analytical methods and demonstrated that the hydrogen-isotopic composition of individual lipids from aquatic and terrestrial organisms can be related to the composition of their growth (i.e., environmental) water. Subsequently, compound-specific deuterium/hydrogen (D/H) ratios of sedimentary biomarkers have been increasingly used as paleohydrological proxies over a range of geological timescales. Isotopic fractionation observed between hydrogen in environmental water and hydrogen in lipids, however, is sensitive to biochemical, physiological, and environmental influences on the composition of hydrogen available for biosynthesis in cells. Here we review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids-especially n-alkanes-from photosynthesizing organisms, and we provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.}, language = {en} } @article{DiLuciaTrecalliMuttietal.2012, author = {Di Lucia, Matteo and Trecalli, A. and Mutti, Maria and Parente, Maria}, title = {Bio-chemostratigraphy of the Barremian-Aptian shallow-water carbonates of the southern Apennines (Italy): pinpointing the OAE1a in a Tethyan carbonate platform}, series = {Solid earth}, volume = {3}, journal = {Solid earth}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1869-9510}, doi = {10.5194/se-3-1-2012}, pages = {1 -- 28}, year = {2012}, abstract = {Low biostratigraphic resolution and lack of chronostratigraphic calibration hinder precise correlations between platform carbonates and coeval deep-water successions. These are the main obstacle when studying the record of Mesozoic oceanic anoxic events in carbonate platforms. In this paper carbon and strontium isotope stratigraphy are used to produce the first chronostratigraphic calibration of the Barremian-Aptian biostratigraphy of the Apenninic carbonate platform of southern Italy. According to this calibration, the segment of decreasing delta C-13 values, leading to the negative peak that is generally taken as the onset of the Selli event, starts a few metres above the last occurrence of Palorbitolina lenticularis and Voloshinoides murgensis. The following rise of delta C-13 values, corresponding to the interval of enhanced accumulation of organic matter in deep-water sections, ends just below the first acme of Salpingoporella dinarica, which roughly corresponds to the segment of peak delta C-13 values. The whole carbon isotope excursion associated with the oceanic anoxic event 1a is bracketed in the Apenninic carbonate platform between the last occurrence of Voloshinoides murgensis and the "Orbitolina level", characterized by the association of Mesorbitolina parva and Mesorbitolina texana. Since these bioevents have been widely recognized beyond the Apenninic platform, the calibration presented in this paper can be used to pinpoint the interval corresponding to the Early Aptian oceanic anoxic event in other carbonate platforms of central and southern Tethys. This calibration will be particularly useful to interpret the record of the Selli event in carbonate platform sections for which a reliable carbon isotope stratigraphy is not available.}, language = {en} } @article{YangBao2012, author = {Yang, Ling and Bao, Hongwei}, title = {Queerly intimate friends, fans and affective communication in a Super Girl fan fiction community}, series = {Cultural studies : theorizing politics, politicizing theory}, volume = {26}, journal = {Cultural studies : theorizing politics, politicizing theory}, number = {6}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0950-2386}, doi = {10.1080/09502386.2012.679286}, pages = {842 -- 871}, year = {2012}, abstract = {This article examines the rise of the Girls' Love (GL) fan fiction community in contemporary China. More specifically, we focus on the 'Pink Super Girl Bar', an online fan fiction community devoted to the pairing of the contestants of the 2006 season of Super Girl, an entertainment program featured on Hunan Satellite TV that enjoys great popularity in the Sinophone world. Through an ethnographic account of the formation, convention and performativity of identities and socialities in this community, we demonstrate how Super Girl GL fans mobilize their emotional capital to create artworks, to have fun and to enrich their everyday lives. We argue that the GL fan fiction community has become a space of female homosociality, intimacy and affect in which a new generation of young Chinese women actively enact friendship and female subjectivity in a way that refuses the normalization of gender, sexuality and social relations. Moreover, by linking fan studies to affect studies and emotional geography, and by paying particular attention to indigenous concepts and cultural practices in mainland China's fan communities, we wish to contribute to fan studies with feminist, queer and transnational perspectives.}, language = {en} } @article{LeuchtTiffinRichardsVocketal.2012, author = {Leucht, Michael and Tiffin-Richards, Simon and Vock, Miriam and Pant, Hans Anand and Koeller, Olaf}, title = {English teachers' diagnostic skills in judging their students' competencies on the basis of the Common European Framework of Reference}, series = {Zeitschrift f{\"u}r Entwicklungspsychologie und p{\"a}dagogische Psychologie}, volume = {44}, journal = {Zeitschrift f{\"u}r Entwicklungspsychologie und p{\"a}dagogische Psychologie}, number = {4}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0049-8637}, doi = {10.1026/0049-8637/a000071}, pages = {163 -- 177}, year = {2012}, abstract = {The present study addresses diagnostic competence of English language teachers at the end of lower secondary education. The 56 teachers assigned each of their respective students (N = 1 363) to a proficiency level of foreign language use according to the Common European Framework of Reference for Languages (CEFR). The teachers' judgements were compared to CEFR proficiency level assignments estimated using data from a reading comprehension assessment of English as a foreign language. The consistency of proficiency level allocations was evaluated using level, differentiation, and ranking components. Beyond providing a description of diagnostic competence, the present study focuses on the influence of classroom halo effects on teachers' CEFR proficiency level judgements by comparing teacher judgments and students' English marks. A multilevel model of diagnostic competence is presented to assess to what extent the rank and level components are influenced by teachers' familiarity with and use of the CEFR guidelines when judging student proficiency.}, language = {fr} } @misc{SuriyanarayananCywinskiMoroetal.2012, author = {Suriyanarayanan, Subramanian and Cywinski, Piotr J. and Moro, Artur J. and Mohr, Gerhard J. and Kutner, Wlodzimierz}, title = {Chemosensors based on molecularly imprinted polymers}, series = {Topics in current chemistry}, volume = {325}, journal = {Topics in current chemistry}, number = {4}, editor = {Haupt, K}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-28421-2}, issn = {0340-1022}, doi = {10.1007/128_2010_92}, pages = {165 -- 265}, year = {2012}, language = {en} } @article{Thorau2012, author = {Thorau, Christian}, title = {Psssst! - In search of the listeners of the past}, series = {Neue Zeitschrift f{\"u}r Musik}, journal = {Neue Zeitschrift f{\"u}r Musik}, number = {5}, publisher = {Schott}, address = {Mainz}, issn = {0945-6945}, pages = {18 -- 22}, year = {2012}, language = {de} } @article{NagyHeinrichGuillonetal.2012, author = {Nagy, Zsuzsanna T. and Heinrich, Benoit and Guillon, Daniel and Tomczyk, Jaroslaw and Stumpe, Joachim and Donnio, Bertrand}, title = {Heterolithic azobenzene-containing supermolecular tripedal liquid crystals self-organizing into highly segregated bilayered smectic phases}, series = {Journal of materials chemistry}, volume = {22}, journal = {Journal of materials chemistry}, number = {35}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0959-9428}, doi = {10.1039/c2jm33751g}, pages = {18614 -- 18622}, year = {2012}, abstract = {Synthesis, self-organization, and optical properties of supermolecular tripedal liquid crystals incorporating various prototypical mesogenic units such as alkoxy-azobenzene (AZB), alkoxy-biphenylene (BPH) or alkoxy-cyanobiphenyl (OCB) derivatives are reported. Different molecular systems were designed in order to sequentially incorporate the smectogenic-like alkoxy-azobenzene-based chromophore within the molecular structure, whose relative proportion is selectively varied by exchanging with the other mesogens. A divergent synthetic mode was elaborated for their synthesis, starting from the regioselective functionalization of the phloroglucinol-based (PG) inner core. This methodology allowed the preparation of several sets of unconventional tripedal oligomers with conjugated heterolithic structures (made of different blocks, e.g. PG(6)AZB(x)BPH(3-x) and PG(6)AZB(x)OCB(3-x), x = 1 or 2) along the homolithic parents (all identical blocks, e.g. PG(z)AZB(3), z = 6 or 11, z is the number of methylene in the spacer between PG and the protomesogen, PG(6)BPH(3), and PG(6)OCB(3)), respectively. Essentially all the synthesized systems behave as thermotropic liquid crystals and show various types of highly segregated multilayered smectic phases, or, in one case, a nematic phase, depending on the nature of the constitutive anisotropic blocks and on the molecular topology (homolithic versus heterolithic, mesogenic ratio x : 3 - x). The effects of these structural modifications on the mesomorphism (mesophase structures, temperature ranges, and thermodynamic stability) have been investigated by differential scanning calorimetry and small-angle X-ray diffraction experiments combined with dilatometric measurements. Models describing the various supramolecular organizations of these tripedes into such multilayered structures are proposed and discussed. Preliminary results of the investigations of their optical properties will also be presented.}, language = {en} } @article{PiephoMartinCreuzburgWacker2012, author = {Piepho, Maike and Martin-Creuzburg, Dominik and Wacker, Alexander}, title = {Phytoplankton sterol contents vary with temperature, phosphorus and silicate supply a study on three freshwater species}, series = {European journal of phycology}, volume = {47}, journal = {European journal of phycology}, number = {2}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0967-0262}, doi = {10.1080/09670262.2012.665484}, pages = {138 -- 145}, year = {2012}, abstract = {The understanding of environmentally induced changes in the biochemical composition of phytoplankton species is of great importance in both physiological studies and ecological food web research. In extensive laboratory experiments we tested the influence of two different temperatures (10 degrees C and 25 degrees C) and a phosphorus supply gradient on the sterol concentrations of the three freshwater phytoplankton species Scenedesmus quadricauda, Cryptomonas ovata and Cyclotella meneghiniana. The diatom C. meneghiniana was additionally exposed to a silicate gradient. In two separate experiments we analysed (1) possible interactive effects of temperature and phosphorus supply and (2) the effect of four phosphorus levels and three silicate levels on algal sterol concentrations. We observed that sterol concentrations were higher at 25 degrees C than at 10 degrees C in S. quadricauda and C. meneghiniana, but were not affected by temperature in C. ovata. Interactive effects of temperature and phosphorus supply on sterol concentrations were found in C. meneghiniana. This presumably was due to the bioconversion of one sterol (24-methylenecholesterol) into another (22-dihydrobrassicasterol). Increasing phosphorus supply resulted in species-specific effects on sterol concentrations, viz. an optimum curve response in S. quadricauda, a saturation curve response in C. meneghiniana and no change in sterol concentration in C. ovata. Effects of silicate supply on the sterols of C. meneghiniana equalled the effects of phosphorus supply. Albeit we did not observe a general trend in the three phytoplankton species tested, we conclude that sterol concentrations of phytoplankton are strongly affected by temperature and nutrient supply. Interactive effects point out the importance of taking into account more than just one environmental factor when assessing the effects of environmentally induced changes on phytoplankton sterol concentrations.}, language = {en} } @article{RadfordFelserBoxell2012, author = {Radford, Andrew and Felser, Claudia and Boxell, Oliver}, title = {Preposition copying and pruning in present-day English}, series = {English language and linguistics}, volume = {16}, journal = {English language and linguistics}, number = {2}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, issn = {1360-6743}, doi = {10.1017/S1360674312000172}, pages = {403 -- 426}, year = {2012}, abstract = {This article investigates the nature of preposition copying and preposition pruning structures in present-day English. We begin by illustrating the two phenomena and consider how they might be accounted for in syntactic terms, and go on to explore the possibility that preposition copying and pruning arise for processing reasons. We then report on two acceptability judgement experiments examining the extent to which native speakers of English are sensitive to these types of 'error' in language comprehension. Our results indicate that preposition copying creates redundancy rather than ungrammaticality, whereas preposition pruning creates processing problems for comprehenders that may render it unacceptable in timed (but not necessarily in untimed) judgement tasks. Our findings furthermore illustrate the usefulness of combining corpus studies and experimentally elicited data for gaining a clearer picture of usage and acceptability, and the potential benefits of examining syntactic phenomena from both a theoretical and a processing perspective.}, language = {en} } @article{CiobanuRabineauDrozetal.2012, author = {Ciobanu, M. -C. and Rabineau, M. and Droz, L. and Revillon, S. and Ghiglione, J. -F. and Dennielou, B. and Jorry, S. -J. and Kallmeyer, Jens and Etoubleau, J. and Pignet, P. and Crassous, P. and Vandenabeele-Trambouze, O. and Laugier, J. and Guegan, M. and Godfroy, A. and Alain, K.}, title = {Sedimentological imprint on subseafloor microbial communities in Western Mediterranean Sea Quaternary sediments}, series = {Biogeosciences}, volume = {9}, journal = {Biogeosciences}, number = {9}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-9-3491-2012}, pages = {3491 -- 3512}, year = {2012}, abstract = {An interdisciplinary study was conducted to evaluate the relationship between geological and paleoenvironmental parameters and the bacterial and archaeal community structure of two contrasting subseafloor sites in the Western Mediterranean Sea (Ligurian Sea and Gulf of Lion). Both depositional environments in this area are well-documented from paleoclimatic and paleooceanographic point of views. Available data sets allowed us to calibrate the investigated cores with reference and dated cores previously collected in the same area, and notably correlated to Quaternary climate variations. DNA-based fingerprints showed that the archaeal diversity was composed by one group, Miscellaneous Crenarchaeotic Group (MCG), within the Gulf of Lion sediments and of nine different lineages (dominated by MCG, South African Gold Mine Euryarchaeotal Group (SAGMEG) and Halobacteria) within the Ligurian Sea sediments. Bacterial molecular diversity at both sites revealed mostly the presence of the classes Alphaproteobacteria, Betaproteobacteria and Gammaproteobacteria within Proteobacteria phylum, and also members of Bacteroidetes phylum. The second most abundant lineages were Actinobacteria and Firmicutes at the Gulf of Lion site and Chloroflexi at the Ligurian Sea site. Various substrates and cultivation conditions allowed us to isolate 75 strains belonging to four lineages: Alpha-, Gammaproteobacteria, Firmicutes and Actinobacteria. In molecular surveys, the Betaproteobacteria group was consistently detected in the Ligurian Sea sediments, characterized by a heterolithic facies with numerous turbidites from a deep-sea levee. Analysis of relative betaproteobacterial abundances and turbidite frequency suggested that the microbial diversity was a result of main climatic changes occurring during the last 20 ka. Statistical direct multivariate canonical correspondence analyses (CCA) showed that the availability of electron acceptors and the quality of electron donors (indicated by age) strongly influenced the community structure. In contrast, within the Gulf of Lion core, characterized by a homogeneous lithological structure of upper-slope environment, most detected groups were Bacteroidetes and, to a lesser extent, Betaproteobacteria. At both site, the detection of Betaproteobacteria coincided with increased terrestrial inputs, as confirmed by the geochemical measurements (Si, Sr, Ti and Ca). In the Gulf of Lion, geochemical parameters were also found to drive microbial community composition. Taken together, our data suggest that the palaeoenvironmental history of erosion and deposition recorded in the Western Mediterranean Sea sediments has left its imprint on the sedimentological context for microbial habitability, and then indirectly on structure and composition of the microbial communities during the late Quaternary.}, language = {en} } @article{MuehlbauerBesemerWehrleetal.2012, author = {M{\"u}hlbauer, Thomas and Besemer, Carmen and Wehrle, Anja and Gollhofer, Albert and Granacher, Urs}, title = {Relationship between strength, power and balance performance in seniors}, series = {Gerontology}, volume = {58}, journal = {Gerontology}, number = {6}, publisher = {Karger}, address = {Basel}, issn = {0304-324X}, doi = {10.1159/000341614}, pages = {504 -- 512}, year = {2012}, abstract = {Background: Deficits in strength, power and balance represent important intrinsic risk factors for falls in seniors. Objective: The purpose of this study was to investigate the relationship between variables of lower extremity muscle strength/power and balance, assessed under various task conditions. Methods: Twenty-four healthy and physically active older adults (mean age: 70 8 5 years) were tested for their isometric strength (i.e. maximal isometric force of the leg extensors) and muscle power (i.e. countermovement jump height and power) as well as for their steady-state (i.e. unperturbed standing, 10-meter walk), proactive (i.e. Timed Up \& Go test, Functional Reach Test) and reactive (i.e. perturbed standing) balance. Balance tests were conducted under single (i.e. standing or walking alone) and dual task conditions (i.e. standing or walking plus cognitive and motor interference task). Results: Significant positive correlations were found between measures of isometric strength and muscle power of the lower extremities (r values ranged between 0.608 and 0.720, p < 0.01). Hardly any significant associations were found between variables of strength, power and balance (i.e. no significant association in 20 out of 21 cases). Additionally, no significant correlations were found between measures of steady-state, proactive and reactive balance or balance tests performed under single and dual task conditions (all p > 0.05). Conclusion: The predominately nonsignificant correlations between different types of balance imply that balance performance is task specific in healthy and physically active seniors. Further, strength, power and balance as well as balance under single and dual task conditions seem to be independent of each other and may have to be tested and trained complementarily.}, language = {en} } @article{LiWangChenetal.2012, author = {Li, Jian and Wang, Zi-Neng and Chen, You-Peng and Dong, Yun-Peng and Mao, Xiao-Min and Hocher, Berthold}, title = {Association of fetal but not maternal P-glycoprotein C3435T polymorphism with fetal growth and birth weight, a possible risk factor for cardiovascular diseases in later life}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {9-10}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2012.110920}, pages = {1085 -- 1089}, year = {2012}, abstract = {Background: The multidrug transporter P-glycoprotein (PGP) is expressed in the human placenta. In particular the C3435T ABCB1 polymorphism was associated with altered tissue expression of PGP in the human placenta. However, the potential functional impact of this polymorphism on the offspring is unknown so far. Methods: We analyzed the impact of the ABCB1/C3435T polymorphism on fetal growth in 262 mother/child pairs. Fetal growth was assessed by differential ultrasound examination of the fetal body prior to birth and by measuring birth weight. Results: The maternal ABCB1/C3435T polymorphism showed no trend for an association with birth weight or any ultrasound parameter describing late gestational fetal body shape. Genotyping the newborns, however, demonstrated that newborns carrying two copies of the T allele had a birth weight of 3176.39 g, whereas CT and CC newborns had a birth weight of 3345.04 g (p = 0.022). Adjusting for gestational age at delivery, child's gender, maternal BM1, maternal age and body weight at delivery confirmed this finding (p = 0.009). Considering gestational day of late ultrasound examination, gestational age at delivery, child's gender, maternal BMI, maternal age and maternal body weight at delivery, the fetal ABCB1/C3435T genotype revealed likewise a significant negative correlation with abdominal diameter and abdominal circumference (R-2 = 0.538, p = 0.010 and R-2 = 0.534, p = 0.005, respectively). Conclusions: Low birth weight may be a risk factor for cardiovascular diseases in later life. The fetal ABCB1/C3435T gene polymorphism may contribute to this risk. Since PGP controls transport of various biological agents, we suggest that PGP is involved in the transport of biological agents to the fetus that are important for normal fetal growth.}, language = {en} } @article{VignonZellwegerRahnenfuehrerTheuringetal.2012, author = {Vignon-Zellweger, Nicolas and Rahnenf{\"u}hrer, Jan and Theuring, Franz and Hocher, Berthold}, title = {Analysis of cardiac and renal endothelin receptors by in situ hybridization in mice}, series = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, volume = {58}, journal = {Clinical laboratory : the peer reviewed journal for clinical laboratories and laboratories related to blood transfusion}, number = {9-10}, publisher = {Clin Lab Publ., Verl. Klinisches Labor}, address = {Heidelberg}, issn = {1433-6510}, doi = {10.7754/Clin.Lab.2012.120216}, pages = {939 -- 949}, year = {2012}, abstract = {Background: Endothelin-1 (ET-1) is a multifunctional peptide, which is implicated in the renal and cardiac physicology as well as in many pathologies of these systems. ET-1's actions take place after the activation of two receptors: ETA and ETB. The expression of these receptors may be modulated during the pathologic process. The analysis of the distribution and level of expression of the receptors in animal models is therefore crucial. Methods: We developed a protocol for non-radioactive in situ hybridization for the mRNA of the two endothelin receptors on paraffin-embedded tissue using digoxigenin-labeled RNA probes. Results: In heart and kidney, the staining was reliable and specific. In a mouse model for endothelin/nitric oxide imbalance, cardiac ETB expression was reduced. The distribution of the receptors was in accordance with the actual knowledge. Differences in cell specific expression are discussed. Conclusions: We developed a protocol for the in situ hybridization of the endothelin receptors in mice. Given that the endothelin system is implicated in the development of many diseases, we believe that this protocol may be useful for a number of future preclinical studies.}, language = {en} } @article{IlnytskyiSaphiannikovaNeheretal.2012, author = {Ilnytskyi, Jaroslav M. and Saphiannikova, Marina and Neher, Dieter and Allen, Michael P.}, title = {Modelling elasticity and memory effects in liquid crystalline elastomers by molecular dynamics simulations}, series = {Soft matter}, volume = {8}, journal = {Soft matter}, number = {43}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c2sm26499d}, pages = {11123 -- 11134}, year = {2012}, abstract = {We performed molecular dynamics simulations of a liquid crystal elastomer of side-chain architecture. The network is formed from a melt of 28 molecules each having a backbone of 100 hydrocarbon monomers, to which 50 side chains are attached in a syndiotactic way. Crosslinking is performed in the smectic A phase. We observe an increase of the smectic-isotropic phase transition temperature of about 5 degrees as compared to the uncrosslinked melt. Memory effects in liquid crystalline order and in sample shape are well reproduced when the elastomer is driven through the smectic-isotropic transition. Above this transition, in the isotropic phase, the polydomain smectic phase is induced by a uniaxial load. Below the transition, in a monodomain smectic A phase, both experimentally observed effects of homogeneous director reorientation and stripe formation are reproduced when the sample is stretched along the director. When the load is applied perpendicularly to the director, the sample demonstrates reversible deformation with no change of liquid crystalline order, indicating elasticity of the two-dimensional network of polymer layers.}, language = {en} } @article{GaertnerNottebrockFourieetal.2012, author = {G{\"a}rtner, Mirijam and Nottebrock, Henning and Fourie, Helanya and Privett, Sean D. J. and Richardson, David M.}, title = {Plant invasions, restoration, and economics perspectives from South African fynbos}, series = {Perspectives in plant ecology, evolution and systematics}, volume = {14}, journal = {Perspectives in plant ecology, evolution and systematics}, number = {5}, publisher = {Elsevier}, address = {Jena}, issn = {1433-8319}, doi = {10.1016/j.ppees.2012.05.001}, pages = {341 -- 353}, year = {2012}, abstract = {Restoration is gaining importance in the management of plant invasions. As the success of restoration projects is frequently determined by factors other than ecological ones, we explored the ecological and financial feasibility of active restoration on three different invaded sites in South Africa's Cape Floristic Region. The aim of our study was to identify cost-effective ways of restoring functional native ecosystems following invasion by alien plants. Over three years we evaluated different restoration approaches using field trials and experimental manipulations (i.e. mechanical clearing, burning, different soil restoration techniques and sowing of native species) to reduce elevated soil nutrient levels and to re-establish native fynbos communities. Furthermore we investigated the possibility of introducing native fynbos species that can be used for sustainable harvesting to create an incentive for restoration on private land. Diversity and evenness of native plant species increased significantly after restoration at all three sites, whereas cover of alien plants decreased significantly, confirming that active restoration was successful. However, sowing of native fynbos species had no significant effect on native cover, species richness, diversity or evenness in the Acacia thicket and Kikuyu field, implying that the ecosystem was sufficiently resilient to allow autogenic recovery following clearing and burning of the invasive species. Soil restoration treatments resulted in an increase of available nitrogen in the Acacia thicket, but had no significant effects in the Eucalyptus plantation. However, despite elevated available soil nitrogen levels, native species germinated irrespective whether sown or unsown (i.e. regeneration from the soil seed bank). Without active introduction of native species, native grasses, forbs and other shrubs would have dominated, and proteoids and ericoids (the major fynbos growth forms) would have been under-represented. The financial analysis shows that income from flower harvesting following active restoration consistently outweighs income following passive restoration, but that the associated increase in income does not always justify the higher costs. We conclude that active restoration can be effective and financially feasible when compared to passive restoration, depending on the density of invasion. Active restoration of densely invaded sites may therefore only be justifiable if the target area is in a region of high conservation priority.}, language = {en} } @misc{Heidler2012, author = {Heidler, Maria-Dorothea}, title = {Clock test in patients with severe aphasia}, series = {Nervenheilkunde : Zeitschrift f{\"u}r interdisziplin{\"a}re Fortbildung}, volume = {31}, journal = {Nervenheilkunde : Zeitschrift f{\"u}r interdisziplin{\"a}re Fortbildung}, number = {11}, publisher = {Schattauer}, address = {Stuttgart}, issn = {0722-1541}, pages = {837 -- 843}, year = {2012}, abstract = {Objective: How do patients with severe aphasia perform in the clock test? Methods:Ten patients with severe aphasia performed the clock test in two modes: copy a given clock (copy condition) and set a clock by drawing the clock hands, where a given digital display (11:10) should be transformed into an analogue display (time setting condition). Results: Not a single patient with severe aphasia was able to master any mode of the clock test. Both copy and time conditions were severely impaired by executive, conceptual, motoric visuospatial and apraxic disorders - impairments of language system were only one of numerous influencing factors. Conclusions and clinical relevance:The clock test measures and requires for its execution so many different cognitive, motoric and perceptual functions that it cannot adequately differentiate between patients with severe aphasia and other severe brain damage.}, language = {de} } @article{BreitenbachRehfeldGoswamietal.2012, author = {Breitenbach, Sebastian Franz Martin and Rehfeld, Kira and Goswami, Bedartha and Baldini, James U. L. and Ridley, H. E. and Kennett, D. J. and Prufer, K. M. and Aquino, Valorie V. and Asmerom, Yemane and Polyak, V. J. and Cheng, Hai and Kurths, J{\"u}rgen and Marwan, Norbert}, title = {Constructing Proxy Records from Age models (COPRA)}, series = {Climate of the past : an interactive open access journal of the European Geosciences Union}, volume = {8}, journal = {Climate of the past : an interactive open access journal of the European Geosciences Union}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1814-9324}, doi = {10.5194/cp-8-1765-2012}, pages = {1765 -- 1779}, year = {2012}, abstract = {Reliable age models are fundamental for any palaeoclimate reconstruction. Available interpolation procedures between age control points are often inadequately reported, and very few translate age uncertainties to proxy uncertainties. Most available modeling algorithms do not allow incorporation of layer counted intervals to improve the confidence limits of the age model in question. We present a framework that allows detection and interactive handling of age reversals and hiatuses, depth-age modeling, and proxy-record reconstruction. Monte Carlo simulation and a translation procedure are used to assign a precise time scale to climate proxies and to translate dating uncertainties to uncertainties in the proxy values. The presented framework allows integration of incremental relative dating information to improve the final age model. The free software package COPRA1.0 facilitates easy interactive usage.}, language = {en} } @article{WildishPavesiKetmaier2012, author = {Wildish, J. and Pavesi, Laura and Ketmaier, Valerio}, title = {Talitrid amphipods (Crustacea: Amphipoda: Talitridae) and the driftwood ecological niche a morphological and molecular study}, series = {Journal of natural history : an international journal of systematics, interactive biology and biodiversity. - London : Taylor \& Francis   1.1967 -}, volume = {46}, journal = {Journal of natural history : an international journal of systematics, interactive biology and biodiversity. - London : Taylor \& Francis   1.1967 -}, number = {43-44}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0022-2933}, doi = {10.1080/00222933.2012.717971}, pages = {2677 -- 2700}, year = {2012}, abstract = {Coastal regions of the North East Atlantic and Mediterranean Seas have four known species of driftwood talitrids. Records are extremely scanty, often limited to the type locality and dating to 1950. We were able to study three of them, all belonging to the genus Macarorchestia, using fresh and archived samples including type material. Allometric and molecular analyses support: (1) a close relationship among all the three classically defined Macarorchestia species, (2) Macarorchestia was well separated from non-driftwood taxa, and (3) a putative new driftwood talitrid discovered during this study was not closely related to Macarorchestia. Genetic divergence between the new species and Macarorchestia remyi is as high as the average distance among a number of talitrid species included in the study for comparison. A key is provided to identify all three of the presently known species of Macarorchestia, using morphological characters employed in the allometric study.}, language = {en} } @article{MuellerStollMuelleretal.2012, author = {M{\"u}ller, Steffen and Stoll, Josefine and M{\"u}ller, Juliane and Mayer, Frank}, title = {Validity of isokinetic trunk measurements with respect to healthy adults, athletes and low back pain patients}, series = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, volume = {20}, journal = {Isokinetics and exercise science : official journal of the European Isokinetic Society}, number = {4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {0959-3020}, doi = {10.3233/IES-2012-00482}, pages = {255 -- 266}, year = {2012}, abstract = {Background: Isokinetic measurements are widely used to assess strength capacity in a clinical or research context. Nevertheless, the validity of isokinetic measures for identifying strength deficits and the evaluation of therapeutic process regarding different pathologies is yet to be established. Therefore, the purpose of this review is to evaluate the validity of isokinetic measures in a specific case: that of muscular capacity in low back pain (LBP). Methods: A literature search (PubMed; ISI Web of Knowledge; The Cochrane Library) covering the last 10 years was performed. Relevant papers regarding isokinetic trunk strength measures in healthy and patients with low back pain (PLBP) were searched. Peak torque values [Nm] and peak torque normalized to body weight [Nm/kg BW] were extracted for healthy and PLBP. Ranked mean values across studies were calculated for the concentric peak torque at 60 degrees/s as well as the flexion/extension (F/E) ratio. Results: 34 publications (31 flexion/extension; 3 rotation) were suitable for reporting detailed isokinetic strength measures in healthy or LBP (untrained adults, adolescents, athletes). Adolescents and athletes were different compared to normal adults in terms of absolute trunk strength values and the F/E ratio. Furthermore, isokinetic measures evaluating therapeutic process and isokinetic rehabilitation training were infrequent in literature (8 studies). Conclusion: Isokinetic measurements are valid for measuring trunk flexion/extension strength and F/E ratio in athletes, adolescents and (untrained) adults with/without LBP. The validity of trunk rotation is questionable due to a very small number of publications whereas no reliable source regarding lateral flexion could be traced. Therefore, isokinetic dynamometry may be utilized for identifying trunk strength deficits in healthy adults and PLBP.}, language = {en} } @article{UhligMadaboosiSchmidtetal.2012, author = {Uhlig, Katja and Madaboosi, Narayanan and Schmidt, Stephan and J{\"a}ger, Magnus S. and Rose, J{\"u}rgen and Duschl, Claus and Volodkin, Dmitry V.}, title = {3d localization and diffusion of proteins in polyelectrolyte multilayers}, series = {Soft matter}, volume = {8}, journal = {Soft matter}, number = {47}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c2sm26500a}, pages = {11786 -- 11789}, year = {2012}, abstract = {The interaction of diverse biomaterials with surfaces is more crucial than ever for biomedical applications to ensure efficiency and reproducibility. Very interesting surface materials are micrometer-thick polyelectrolyte multilayers. Not only their surface but also the bulk can be loaded with biomaterials like proteins or DNA for various purposes. Therefore, we established a method to analyze the lateral and vertical distribution of fluorescently labelled proteins of various size and charge in polyelectrolyte films composed of poly(L-lysine) and hyaluronic acid by confocal laser scanning microscopy. This approach enables us to measure the diffusion coefficients of the proteins via fluorescence recovery after photobleaching as a function of their vertical position in the film and facilitates the understanding of molecular interactions in the film with a high resolution in both space and time. As a result, we confirm that protein loading in the film is driven by electrostatic interactions - uncharged dextran molecules of 10 and 500 kDa do not diffuse into the film. Proteins of different sizes (3-11 nm) can diffuse relatively fast (D = 2-4 mm(2) s(-1)) independent of their net charge, indicating complex interpolymer interactions. This approach is a new powerful experimental tool to design the polyelectrolyte multilayers for bio-applications by finding a relationship between intermolecular interactions and mobility and availability of biomolecules to biological samples (e.g. cells) or detection units (e.g. biosensors).}, language = {en} } @article{SchneiderKohlSauteretal.2012, author = {Schneider, Tobias and Kohl, Benjamin and Sauter, Tilman and Kratz, Karl and Lendlein, Andreas and Ertel, Wolfgang and Schulze-Tanzil, Gundula}, title = {Influence of fiber orientation in electrospun polymer scaffolds on viability, adhesion and differentiation of articular chondrocytes}, series = {Clinical hemorheology and microcirculation : blood flow and vessels}, volume = {52}, journal = {Clinical hemorheology and microcirculation : blood flow and vessels}, number = {2-4}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1386-0291}, doi = {10.3233/CH-2012-1608}, pages = {325 -- 336}, year = {2012}, abstract = {Degradable polymers with a tailorable degradation rate might be promising candidate materials for biomaterial-based cartilage repair. In view of the poor intrinsic healing capability of cartilage, implantation of autologous chondrocytes seeded on a biocompatible slow degrading polymer might be an encouraging approach to improve cartilage repair in the future. This study was undertaken to test if the fiber orientation (random versus aligned) of two different degradable polymers and a polymer intended for long term applications could influence primary articular chondrocytes growth and ultrastructure. A degradable copoly(ether) esterurethane (PDC) was synthesized via co-condensation of poly(p-dioxanone) diol and poly(epsilon-caprolactone) diol using an aliphatic diisocyanate as linker. Poly(p-dioxanone) (PPDO) was applied as commercially available degradable polymer, while polyetherimide (PEI) was chosen as biomaterial enabling surface functionalization. The fibrous scaffolds of PDC and PPDO were obtained by electrospinning using 1,1,1,3,3,3 hexafluoro-2-propanol (HFP), while for PEI dimethyl acetamide (DMAc) was applied as solvent. Primary porcine articular chondrocytes were seeded at different cell densities on the fibrous polymer scaffolds and analyzed for viability (fluorescein diacetate/ethidiumbromide staining), for type II collagen synthesis (immunolabelling), ultrastructure and orientation on the fibers (SEM: scanning electron microscopy). Vital chondrocytes adhered on all electrospun scaffolds irrespective of random and aligned topologies. In addition, the chondrocytes produced the cartilage-specific type II collagen on all tested polymer topologies suggesting their differentiated functions. SEM revealed an almost flattened chondrocytes shape on scaffolds with random fiber orientation: whereby chondrocytes growth remained mainly restricted to the scaffold surface. On aligned fibers the chondrocytes exhibited a more spindle-shaped morphology with rougher cell surfaces but only a minority of the cells aligned according to the fibers. As a next step the reduction of the fiber diameter of electrospun scaffolds should be addressed as an important parameter to mimic cartilage ECM structure.}, language = {en} } @misc{SommerAdrianDomisetal.2012, author = {Sommer, Ulrich and Adrian, Rita and Domis, Lisette Nicole de Senerpont and Elser, James J. and Gaedke, Ursula and Ibelings, Bas and Jeppesen, Erik and Lurling, Miquel and Molinero, Juan Carlos and Mooij, Wolf M. and van Donk, Ellen and Winder, Monika}, title = {Beyond the Plankton Ecology Group (PEG) Model mechanisms driving plankton succession}, series = {Annual review of ecology, evolution, and systematics}, volume = {43}, journal = {Annual review of ecology, evolution, and systematics}, number = {2-4}, editor = {Futuyma, DJ}, publisher = {Annual Reviews}, address = {Palo Alto}, isbn = {978-0-8243-1443-9}, issn = {1543-592X}, doi = {10.1146/annurev-ecolsys-110411-160251}, pages = {429 -- 448}, year = {2012}, abstract = {The seasonal succession of plankton is an annually repeated process of community assembly during which all major external factors and internal interactions shaping communities can be studied. A quarter of a century ago, the state of this understanding was described by the verbal plankton ecology group (PEG) model. It emphasized the role of physical factors, grazing and nutrient limitation for phytoplankton, and the role of food limitation and fish predation for zooplankton. Although originally targeted at lake ecosystems, it was also adopted by marine plankton ecologists. Since then, a suite of ecological interactions previously underestimated in importance have become research foci: overwintering of key organisms, the microbial food web, parasitism, and food quality as a limiting factor and an extended role of higher order predators. A review of the impact of these novel interactions on plankton seasonal succession reveals limited effects on gross seasonal biomass patterns, but strong effects on species replacements.}, language = {en} } @misc{Kueppers2012, author = {K{\"u}ppers, Patrick}, title = {Ingo St{\"o}ckmann: Der Wille zum Willen. Der Naturalismus und die Gr{\"u}ndung der literarischen Moderne 1880-1900, Berlin/New York: Walter de Gruyter 2009, 561 S.}, series = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, volume = {64}, journal = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, number = {3}, publisher = {Brill}, address = {Leiden}, issn = {0044-3441}, doi = {10.1163/15700739-90000016}, pages = {303 -- 304}, year = {2012}, language = {de} } @article{SalazarFrancesKommaetal.2012, author = {Salazar, S. and Frances, F. and Komma, J. and Blume, Theresa and Francke, Till and Bronstert, Axel and Bl{\"o}schl, G{\"u}nter}, title = {A comparative analysis of the effectiveness of flood management measures based on the concept of "retaining water in the landscape" in different European hydro-climatic regions}, series = {Natural hazards and earth system sciences}, volume = {12}, journal = {Natural hazards and earth system sciences}, number = {11}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1561-8633}, doi = {10.5194/nhess-12-3287-2012}, pages = {3287 -- 3306}, year = {2012}, abstract = {In this paper, we analyse the effectiveness of flood management measures based on the concept known as "retaining water in the landscape". The investigated measures include afforestation, micro-ponds and small-reservoirs. A comparative and model-based methodological approach has been developed and applied for three meso-scale catchments located in different European hydro-climatological regions: Poyo (184 km(2)) in the Spanish Mediterranean, Upper Iller (954 km(2)) in the German Alps and Kamp (621 km(2)) in Northeast-Austria representing the Continental hydro-climate. This comparative analysis has found general similarities in spite of the particular differences among studied areas. In general terms, the flood reduction through the concept of "retaining water in the landscape" depends on the following factors: the storage capacity increase in the catchment resulting from such measures, the characteristics of the rainfall event, the antecedent soil moisture condition and the spatial distribution of such flood management measures in the catchment. In general, our study has shown that, this concept is effective for small and medium events, but almost negligible for the largest and less frequent floods: this holds true for all different hydro-climatic regions, and with different land-use, soils and morphological settings.}, language = {en} } @article{LagodelaHorraUbideetal.2012, author = {Lago, M. and de la Horra, R. and Ubide, T. and Gale, C. and Galan-Abellan, B. and Barrenechea, J. F. and Lopez-Gomez, J. and Benito, M. I. and Arche, A. and Alonso-Azcarate, J. and Luque, F. J. and Timmerman, Martin Jan}, title = {First report of a Middle-Upper Permian magmatism in the SE Iberian Ranges characterisation and comparison with coeval magmatisms in the western Tethys}, series = {Journal of Iberian geology}, volume = {38}, journal = {Journal of Iberian geology}, number = {2}, publisher = {Instituto de Geolog{\´i}a Econ{\´o}mica, Consejo Superior de Investigaciones Cient{\´i}ficas, Universidad Complutense Madrid}, address = {Madrid}, issn = {1698-6180}, doi = {10.5209/rev_JIGE.2012.v38.n2.40462}, pages = {331 -- 348}, year = {2012}, abstract = {A multiple basic to intermediate sill is reported for the first time in the south-eastern Iberian Ranges. It is composed of several tabular to irregular levels intercalated within the fluvial sediments of the Alcotas Formation (Middle-Upper Permian). The sill could represent the youngest Paleozoic subvolcanic intrusion in the Iberian Ranges. The igneous rocks are classified as basaltic andesites. They show a subophitic microstructure constituted by plagioclase (An62 - An6), augite (En48Wo44Fs7 - En46Wo39Fs15), pseudomorphosed olivine, minor amounts of oxides (magnetite and ilmenite) and accessory F-apatite. According to the mineralogy and whole-rock composition, their geochemical affinity is transitional from subalkaline to alkaline. Radiometric dating of the sill is not feasible due to its significant alteration. Field criteria, however, suggest an emplacement coeval to the deposition of the Alcotas Formation (Middle-Upper Permian). This hypothesis is supported by the transitional affinity of these rocks, similar to other Middle-Upper Permian magmatisms in the western Tethys, e.g., from the Pyrenees. Taking into account their isotopic signature (epsilon(Sr) : -6.8 to -9.2; epsilon(Nd) : + 1.7 to + 8.3), an enriched mantle source with the involvement of a HIMU component has been identified. This interpretation is supported by the trace element contents. Some of these HIMU characteristics have been recognised in the Middle-Upper Permian magmatisms of the Central Pyrenees (Anayet Basin) and the High Atlas (Argana Basin). However, none of these source features are shared with other Middle-Upper Permian magmatisms of the western Tethys (Catalonian Coastal Ranges, Corsica-Sardinia and southern France), nor with the Lower Permian magmatism of the Iberian Ranges. These differences support the presence of a heterogeneous mantle in the western Tethys during the Permian.}, language = {en} } @article{KrausEngbertDollingeretal.2012, author = {Kraus, Uta and Engbert, Kai and Dollinger, Anika and Heiss, Christian and Brand, Ralf}, title = {Evaluation of a mitial interview guide for sport psychology counseling}, series = {Zeitschrift f{\"u}r Sportpsychologie}, volume = {19}, journal = {Zeitschrift f{\"u}r Sportpsychologie}, number = {4}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {1612-5010}, doi = {10.1026/1612-5010/a000080}, pages = {145 -- 162}, year = {2012}, abstract = {The initial interview is important for psychological counseling regarding the acquisition of diagnostic information and in terms of establishing a professional counseling relationship. In applied sports psychology there so far exist no clear guidelines to structure this process. To improve the quality of sports psychological consultations, the present study introduces and evaluates a semi-structured guideline for an initial interview in which the content and form of the consultation are determined, the concerns of the client are systematically explored, and the objectives of the collaboration and the further process are defined. Eleven sport psychology trainees participated in our study and conducted initial interviews with actors. One interview was conducted by using the initial interview guide and the other interview was created individually by each sport psychology trainee based on his own expertise. The results showed that the quality of the interview process (i.e., formal requirements, use of open questions) as well as the satisfaction of the consultant with the interview was significantly higher when following the guideline. No differences were found regarding the quality of the consultation findings and the satisfaction of the athletes with the interview. The results are discussed with respect to their theoretical and practical implications.}, language = {de} } @article{KostaKrivochen2012, author = {Kosta, Peter and Krivochen, Diego Gabriel}, title = {Some thoughts on language diversity, UG and the importance of language typology scrambling and non-monotonic merge of adjuncts and specifiers in Czech and German}, series = {Zeitschrift f{\"u}r Slawistik}, volume = {57}, journal = {Zeitschrift f{\"u}r Slawistik}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0044-3506}, pages = {377 -- 407}, year = {2012}, abstract = {The following article is concerned with the problem of language diversity within the framework of Radical Minimalism (Krivochen 2011, 2012). How can the diversity and variation of languages be explained? For Noam Chomsky, language faculty in the narrow sense (FLN) is nothing but an "organ of the body,' along with other cognitive systems. Our analysis of human language builds on Chomsky's (1995, 2005, 2010) minimalist assumption that the design of language is grounded in conceptual necessity. Adopting this idea, we expect to find three factors that interact to determine (I-) languages attained: genetic endowment (the topic of Universal Grammar), experience, and principles that are language- or even organism-independent." (Chomsky 2005:1). In the present article we provide some ideas about how generative research based on Radical Minimalism can contribute on a par with the typology of languages to a more profound and sound exploration of language variation. The scope of the paper is to compare the distribution of adverbs within the three domains of the clause in Czech and German. The aim of this paper is to show that the feature-based theory of adverb licensing is not able to handle the problem of adverb order variation. Instead, a more parsimonious approach based on the Theory of Radical Minimalism will be chosen. The paper is organized as follows: After some remarks on the role of Universal Grammar, Variation and Typology in section 1, section 2 introduces the theoretical background by introducing the principles and the core of Radical Minimalism, e.g. free unbounded merge, asymmetric c-command and the restrictions within the clause structure composition. In section 3, the distribution of adverbs in the middle field is discussed for Czech and German. In the last part, we introduce the so-called Late Adjunction Hypothesis that results in similar effects to the Early Spell-Out model argued for in our paper.}, language = {en} } @article{MenzLatorreSchuetteetal.2012, author = {Menz, Stephan and Latorre, Juan C. and Sch{\"u}tte, Christof and Huisinga, Wilhelm}, title = {Hybrid stochastic-deterministic solution of the chemical master equation}, series = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, volume = {10}, journal = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, number = {4}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {1540-3459}, doi = {10.1137/110825716}, pages = {1232 -- 1262}, year = {2012}, abstract = {The chemical master equation (CME) is the fundamental evolution equation of the stochastic description of biochemical reaction kinetics. In most applications it is impossible to solve the CME directly due to its high dimensionality. Instead, indirect approaches based on realizations of the underlying Markov jump process are used, such as the stochastic simulation algorithm (SSA). In the SSA, however, every reaction event has to be resolved explicitly such that it becomes numerically inefficient when the system's dynamics include fast reaction processes or species with high population levels. In many hybrid approaches, such fast reactions are approximated as continuous processes or replaced by quasi-stationary distributions in either a stochastic or a deterministic context. Current hybrid approaches, however, almost exclusively rely on the computation of ensembles of stochastic realizations. We present a novel hybrid stochastic-deterministic approach to solve the CME directly. Our starting point is a partitioning of the molecular species into discrete and continuous species that induces a partitioning of the reactions into discrete-stochastic and continuous-deterministic processes. The approach is based on a WKB (Wentzel-Kramers-Brillouin) ansatz for the conditional probability distribution function (PDF) of the continuous species (given a discrete state) in combination with Laplace's method of integral approximation. The resulting hybrid stochastic-deterministic evolution equations comprise a CME with averaged propensities for the PDF of the discrete species that is coupled to an evolution equation of the related expected levels of the continuous species for each discrete state. In contrast to indirect hybrid methods, the impact of the evolution of discrete species on the dynamics of the continuous species has to be taken into account explicitly. The proposed approach is efficient whenever the number of discrete molecular species is small. We illustrate the performance of the new hybrid stochastic-deterministic approach in an application to model systems of biological interest.}, language = {en} } @article{MelnickMorenoCisternasetal.2012, author = {Melnick, Daniel and Moreno, Marcos and Cisternas, Marco and Tassara, Andres}, title = {Darwin seismic gap closed by the 2010 Maule earthquake}, series = {Andean geology}, volume = {39}, journal = {Andean geology}, number = {3}, publisher = {Servicio Nacional de Geolog{\`i}a y Miner{\`i}a}, address = {Santiago}, issn = {0718-7092}, doi = {10.5027/andgeoV39n3-a11}, pages = {558 -- 563}, year = {2012}, abstract = {The Maule earthquake (Mw 8.8) that affected south-central Chile on February 27, 2010 was preceded by the 1835 event documented by FitzRoy and Darwin. The relation between both events has been controversial. Fault slip in 2010 estimated by Lorito et al. (2011) is less than expected from 175 years of strain accumulation, leading them to conclude only limited overlap between the 2010 and 1835 events, and that a Mw 7.5-8 event could still strike the Concepcion region. However, Lorito et al.'s model was based on displacements obtained from only 6 GPS stations and underpredicts observations from recent studies. Here we show that an alternative model based on 169 GPS displacements reproduces the data better, suggesting Lorito et al.'s main conclusion is not correct. Based on a slip deficit map, we suggest the seismic gap opened in 1835 was most likely closed in 2010.}, language = {en} } @misc{Stecker2012, author = {Stecker, Christian}, title = {The role of governments in legislative agenda setting}, series = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, volume = {53}, journal = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, number = {4}, publisher = {Nomos}, address = {Hannover}, issn = {0032-3470}, pages = {703 -- 705}, year = {2012}, language = {de} } @misc{Ganghof2012, author = {Ganghof, Steffen}, title = {The order of public reason a theory of freedom and morality in a diverse and bounded world}, series = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, volume = {53}, journal = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, number = {4}, publisher = {Nomos}, address = {Hannover}, issn = {0032-3470}, pages = {692 -- 695}, year = {2012}, language = {de} } @misc{Kueppers2012, author = {K{\"u}ppers, Patrick}, title = {Ingo St{\"o}ckmann: Naturalismus. Lehrbuch Germanistik, Stuttgart: J. B. Metzler 2011, 198+IX S.}, series = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, volume = {64}, journal = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, number = {4}, publisher = {Brill}, address = {Leiden}, issn = {0044-3441}, doi = {10.1163/15700739-90000030}, pages = {412 -- 413}, year = {2012}, language = {de} } @article{Schneider2012, author = {Schneider, Ulrike}, title = {Positionings in early post-war literature Jean Amery and Alfred Andersch}, series = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, volume = {64}, journal = {Zeitschrift f{\"u}r Religions- und Geistesgeschichte}, number = {4}, publisher = {Brill}, address = {Leiden}, issn = {0044-3441}, pages = {313 -- 337}, year = {2012}, language = {de} } @article{Knobloch2012, author = {Knobloch, J{\"o}rn}, title = {Between self-reference and other-reference typology and transformation of authoritarianism within the world society}, series = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, journal = {Politische Vierteljahresschrift : Zeitschrift der Deutschen Vereinigung f{\"u}r Politische Wissenschaft}, number = {4}, publisher = {Nomos}, address = {Hannover}, issn = {0032-3470}, pages = {35 -- +}, year = {2012}, abstract = {Jorn Knobloch, Between Self-reference and Other-reference: Typology and Transformation of Authoritarianism within the World Society, pp. 35-59. The article offers a conceptual framework for the analysis of the interdependence of the world society and the new authoritarianism. At first the article criticizes existing conceptual approaches and develops a new approach, which will use the assumptions of the systems theory. In the next part we discuss different theoretical impacts of the world society and the possible reactions of the authoritarianism. The third part evaluates the theoretical reactions. Therefore we use the empirical case of Russia. The empirical investigation of the approach permits the development of a conceptual framework for the further empirical research of the new authoritarianism.}, language = {de} } @article{AlterOttvonWebskyetal.2012, author = {Alter, Markus L. and Ott, Ina M. and von Websky, Karoline and Tsuprykov, Oleg and Sharkovska, Yuliya and Krause-Relle, Katharina and Raila, Jens and Henze, Andrea and Klein, Thomas and Hocher, Berthold}, title = {DPP-4 Inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, volume = {36}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, number = {1}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000341487}, pages = {119 -- 130}, year = {2012}, abstract = {Background: The need for an improved treatment for diabetic nephropathy is greatest in patients who do not adequately respond to angiotensin II receptor blockers (ARBs). This study investigated the effect of the novel dipeptidyl peptidase-4 inhibitor linagliptin alone and in combination with the ARB telmisartan on the progression of diabetic nephropathy in diabetic endothelial nitric oxide synthase (eNOS) knockout mice. Methods: Sixty male eNOS knockout C57BL/6J mice were divided into four groups after receiving intraperitoneal high-dose streptozotocin: telmisartan (1 mg/kg), linagliptin (3 mg/kg), linagliptin + telmisartan (3 mg/kg + 1 mg/kg) and vehicle. Fourteen mice were used as non-diabetic controls. Results: After 12 weeks, urine and blood were obtained and blood pressure measured. Glucose concentrations were increased and similar in all diabetic groups. Telmisartan alone reduced systolic blood pressure by 5.9 mmHg versus diabetic controls (111.2 +/- 2.3 mmHg vs 117.1 +/- 2.2 mmHg; mean +/- SEM; P = 0.071). Combined treatment significantly reduced albuminuria compared with diabetic controls (71.7 +/- 15.3 mu g/24 h vs 170.8 +/- 34.2 mu g/24 h; P = 0.017), whereas the effects of single treatment with either telmisartan (97.8 +/- 26.4 mu g/24 h) or linagliptin (120.8 +/- 37.7 mu g/24 h) were not statistically significant. DPP-4 inhibition, alone and in combination, led to significantly lower plasma osteopontin levels compared with telmisartan alone. Histological analysis revealed reduced glomerulosclerosis after Linagliptin alone and in combination with telmisartan in comparison to non treated diabetic animals (p < 0.01 and p < 0.05). Kidney malonaldehyde immune-reactivity, a marker of oxidative stress, was significantly lower in animals treated with linagliptin. Conclusions: DPP-4 inhibition on top of ARB treatment significantly reduced urinary albumin excretion and oxidative stress in diabetic eNOS knockout mice. Linagliptin on top of an angiotensin II receptor blocker may offer a new therapeutic approach for patients with diabetic nephropathy.}, language = {en} } @misc{HocherReichetzederAlter2012, author = {Hocher, Berthold and Reichetzeder, Christoph and Alter, Markus L.}, title = {Renal and cardiac effects of DPP-4 inhibitors - from preclinical development to clinical research}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, volume = {36}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, number = {1}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000339028}, pages = {65 -- 84}, year = {2012}, abstract = {Inhibitors of type 4 dipeptidyl peptidase (DDP-4) were developed and approved for the oral treatment of type 2 diabetes. Its mode of action is to inhibit the degradation of incretins, such as type 1 glucagon like peptide (GLP-1), and GIP. GLP-1 stimulates glucose-dependent insulin secretion from pancreatic beta-cells and suppresses glucagon release from alpha-cells, thereby improving glucose control. Besides its action on the pancreas type 1 glucagon like peptide has direct effects on the heart, vessels and kidney mainly via the type 1 glucagon like peptide receptor (GLP-1R). Moreover, there are substrates of DPP-4 beyond incretins that have proven renal and cardiovascular effects such as BNP/ANP, NPY, PYY or SDF-1 alpha. Preclinical evidence suggests that DPP-4 inhibitors may be effective in acute and chronic renal failure as well as in cardiac diseases like myocardial infarction and heart failure. Interestingly, large cardiovascular meta-analyses of combined Phase II/III clinical trials with DPP-4 inhibitors point all in the same direction: a potential reduction of cardiovascular events in patients treated with these agents. A pooled analysis of pivotal Phase III, placebo-controlled, registration studies of linagliptin further showed a significant reduction of urinary albumin excretion after 24 weeks of treatment. The observation suggests direct renoprotective effects of DPP-4 inhibition that may go beyond its glucose-lowering potential. Type 4 dipeptidyl peptidase inhibitors have been shown to be very well tolerated in general, but for those excreted via the kidney dose adjustments according to renal function are needed to avoid side effects. In conclusion, the direct cardiac and renal effects seen in preclinical studies as well as meta-analysis of clinical trials may offer additional potentials - beyond improvement of glycemic control - for this newer class of drugs, such as acute kidney failure, chronic kidney failure as well as acute myocardial infarction and heart failure.}, language = {en} } @misc{WelkerDittmannThuenemannvonDoehren2012, author = {Welker, Martin and Dittmann-Th{\"u}nemann, Elke and von Doehren, Hans}, title = {Cyanobacteria as a source of natural products}, series = {Methods in enzymology}, volume = {517}, journal = {Methods in enzymology}, number = {1}, editor = {Hopwood, DA}, publisher = {Elsevier}, address = {San Diego}, isbn = {978-0-12-404634-4}, issn = {0076-6879}, doi = {10.1016/B978-0-12-404634-4.00002-4}, pages = {23 -- 46}, year = {2012}, abstract = {Cyanobacteria or blue-green algae from various environments have been recognized as sources of a variety of bioactive metabolites. Strategies of strain isolation from aquatic habitats, and cultivation and harvesting for metabolite production are described. Strategies for screening of compounds are discussed, including their direct MALDI-TOF mass spectrometric detection in whole cells. Genetic approaches including genomic mining, mutagenesis including transcriptional activation, heterologous expression, and in vitro. reconstitution of pathways are presented.}, language = {en} } @misc{MulderBoitMorietal.2012, author = {Mulder, Christian and Boit, Alice and Mori, Shigeta and Vonk, J. Arie and Dyer, Scott D. and Faggiano, Leslie and Geisen, Stefan and Gonzalez, Angelica L. and Kaspari, Michael and Lavorel, Sandra and Marquet, Pablo A. and Rossberg, Axel G. and Sterner, Robert W. and Voigt, Winfried and Wall, Diana H.}, title = {Distributional (In)Congruence of Biodiversity-Ecosystem Functioning}, series = {Advances in ecological research}, volume = {46}, journal = {Advances in ecological research}, editor = {Jacob, U and Woodward, G}, publisher = {Elsevier}, address = {San Diego}, isbn = {978-0-12-396992-7}, issn = {0065-2504}, doi = {10.1016/B978-0-12-396992-7.00001-0}, pages = {1 -- 88}, year = {2012}, abstract = {The majority of research on biodiversity ecosystem functioning in laboratories has concentrated on a few traits, but there is increasing evidence from the field that functional diversity controls ecosystem functioning more often than does species number. Given the importance of traits as predictors of niche complementarity and community structures, we (1) examine how the diversity sensu lato of forest trees, freshwater fishes and soil invertebrates might support ecosystem functioning and (2) discuss the relevance of productive biota for monophyletic assemblages (taxocenes). In terrestrial ecosystems, correlating traits to abiotic factors is complicated by the appropriate choice of body-size distributions. Angiosperm and gymnosperm trees, for example, show metabolic incongruences in their respiration rates despite their pronounced macroecological scaling. Scaling heterotrophic organisms within their monophyletic assemblages seems more difficult than scaling autotrophs: in contrast to the generally observed decline of mass-specific metabolic rates with body mass within metazoans, soil organisms such as protozoans show opposite mass-specific trends. At the community level, the resource demand of metazoans shapes multitrophic interactions. Hence, population densities and their food web relationships reflect functional diversity, but the influence of biodiversity on stability and ecosystem functioning remains less clear. We focused on fishes in 18 riverine food webs, where the ratio of primary versus secondary extinctions (hereafter, 'extinction partitioning') summarizes the responses of fish communities to primary species loss (deletions) and its consequences. Based on extinction partitioning, our high-diversity food webs were just as (or even more) vulnerable to extinctions as low-diversity food webs. Our analysis allows us to assess consequences of the relocation or removal of fish species and to help with decision-making in sustainable river management. The study highlights that the topology of food webs (and not simply taxonomic diversity) plays a greater role in stabilizing the food web and enhancing ecological services than is currently acknowledged.}, language = {en} } @article{ChengLenkoshi2012, author = {Cheng, Yuan and Lenkoshi, Alex}, title = {Hierarchical gaussian graphical models beyond reversible jump}, series = {Electronic journal of statistics}, volume = {6}, journal = {Electronic journal of statistics}, publisher = {Institute of Mathematical Statistics}, address = {Cleveland}, issn = {1935-7524}, doi = {10.1214/12-EJS746}, pages = {2309 -- 2331}, year = {2012}, abstract = {The Gaussian Graphical Model (GGM) is a popular tool for incorporating sparsity into joint multivariate distributions. The G-Wishart distribution, a conjugate prior for precision matrices satisfying general GGM constraints, has now been in existence for over a decade. However, due to the lack of a direct sampler, its use has been limited in hierarchical Bayesian contexts, relegating mixing over the class of GGMs mostly to situations involving standard Gaussian likelihoods. Recent work has developed methods that couple model and parameter moves, first through reversible jump methods and later by direct evaluation of conditional Bayes factors and subsequent resampling. Further, methods for avoiding prior normalizing constant calculations-a serious bottleneck and source of numerical instability-have been proposed. We review and clarify these developments and then propose a new methodology for GGM comparison that blends many recent themes. Theoretical developments and computational timing experiments reveal an algorithm that has limited computational demands and dramatically improves on computing times of existing methods. We conclude by developing a parsimonious multivariate stochastic volatility model that embeds GGM uncertainty in a larger hierarchical framework. The method is shown to be capable of adapting to swings in market volatility, offering improved calibration of predictive distributions.}, language = {en} } @article{WolfPolzenhagen2012, author = {Wolf, Hans-Georg and Polzenhagen, Frank}, title = {Cognitive sociolinguistics in L2-variety dictionaries of english}, series = {Review of cognitive linguistics}, volume = {10}, journal = {Review of cognitive linguistics}, number = {2}, publisher = {Benjamins}, address = {Amsterdam}, issn = {1877-9751}, doi = {10.1075/rcl.10.2.06wol}, pages = {373 -- 400}, year = {2012}, abstract = {The recent decades have witnessed the incorporation of new linguistic trends into lexicography. One of these trends is a usage-based approach, with the first major application of computer-corpus data in the Collins COBUILD English dictionary (1995) and successive adaptation in other L1-dictionaries. Another, concurrent innovation-inspired by Conceptual Metaphor Theory-is the provision of conceptual information in monolingual dictionaries of English. So far, however, only the Macmillan English dictionary for advanced learners (1st and 2nd edition) has paid tribute to the fact that understanding culturespecific metaphors and being aware of metaphoric usage are crucial for learning a foreign language. Given that most of the English as lingua franca interactions take place between L2-speakers of English (see Kachru, 1994), providing conceptual information is not only a desideratum for L1- and learner dictionaries, but especially for (L2-) variety dictionaries of English. In our paper, we follow earlier tentative proposals by Polzenhagen (2007) and Wolf (2012) and present examples from A dictionary of Hong Kong English (Cummings \& Wolf, 2011), showing how culturally salient conceptual information can be made explicit and conceptual links between lexical items retrievable. The examples demonstrate that fixed expressions and idioms -a perennial problem for lexicographers are explicable by means of the proposed lexicographic design, too. Our approach is cognitive-sociolinguistic in that the Conceptual Metaphor approach is coupled with the study of regional varieties of English, more specifically Hong Kong English. Our analysis is empirically backed up by corpus-linguistic insights into this L2 variety.}, language = {en} } @article{SzelatWehr2012, author = {Szelat, Sebastian and Wehr, Katharina}, title = {"Military history editions today new challenges, old problems?" Workshop of the military history research institute, 1-2 June 2012 in Potsdam}, series = {Milit{\"a}rgeschichtliche Zeitschrift}, volume = {71}, journal = {Milit{\"a}rgeschichtliche Zeitschrift}, number = {2}, publisher = {De Gruyter Oldenbourg}, address = {Potsdam}, issn = {2193-2336}, pages = {398 -- 402}, year = {2012}, language = {de} } @article{GhobadiHeuchelKratzetal.2012, author = {Ghobadi, Ehsan and Heuchel, Matthias and Kratz, Karl and Lendlein, Andreas}, title = {Simulation of volumetric swelling of degradable poly[(rac-lactide)-co-glycolide] based polyesterurethanes containing different urethane-linkers}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10432}, pages = {293 -- 301}, year = {2012}, abstract = {Aim: The hydrolytic degradation behavior of degradable aliphatic polyester-based polymers is strongly influenced by the uptake or transport of water into the polymer matrix and also the hydrolysis rate of ester bonds. Methods: We examined the volumetric swelling behavior of poly[(rac-lactide)-co-glycolide] (PLGA) and PLGA-based polyurethanes (PLGA-PU) with water contents of 0 wt\%, 2 wt\% and 7 wt\% water at 310 K using a molecular modeling approach. Polymer systems with a number average molecular weight of M-n = 10,126 g.mol(-1) were constructed from PLGA with a lactide content of 67 mol\%, whereby PLGA-PU systems were composed of five PLGA segments with M-n = 2052 g.mol(-1), which were connected via urethane linkers originated from 2,2,4-trimethyl hexamethylene-1,6-diisocyanate (TMDI), hexamethyl-1,6-diisocyanate (HDI), or L-lysine-1,6-diisocyanate (LDI). Results: The calculated densities of the dry PLGA-PU systems were found to be lower than for pure PLGA. The obtained volumetric swelling of the PLGA-PU was depending on the type of urethane linker, whereby all swollen PLGA-PUs contained larger free volume distribution compared to pure PLGA. The mean square displacement curves for dry PLGA and PLGA-PUs showed that urethane linker units reduce the mobility of the polymer chains, while an increase in backbone atoms mobility was found, when water was added to these systems. Consequently, an increased water uptake of PLGA-PU matrices combined with a higher mobility of the chain segments should result in an accelerated hydrolytic chain scission rate in comparison to PLGA. Conclusions: It can be anticipated that the incorporation of urethane linkers might be a helpful tool to adjust the degradation behavior of polyesters.}, language = {en} } @article{FriessWischkeBehletal.2012, author = {Friess, Fabian and Wischke, Christian and Behl, Marc and Lendlein, Andreas}, title = {Oligo(epsilon-caprolactone)-based polymer networks prepared by photocrosslinking in solution}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10372}, pages = {273 -- 279}, year = {2012}, abstract = {Purpose: Polymer networks with adjustable properties prepared from endgroup-functionalized oligoesters by UV-crosslinking in melt have evolved into versatile multifunctional biomaterials. In addition to the molecular weight or architecture of precursors, the reaction conditions for crosslinking are pivotal for the polymer network properties. Crosslinking of precursors in solution may facilitate low-temperature processes and are compared here to networks synthesized in melt. Methods: Oligo(epsilon-caprolactone)-(z) methacrylate (oCL-(z) IEMA) precursors with a linear (z = di) or a four-armed star-shaped (z = tetra) architecture were crosslinked by radical polymerization in melt or in solution with UV irradiation. The thermal, mechanical, and swelling properties of the polymer networks obtained were characterized. Results: Crosslinking in solution resulted in materials with lower Young's moduli (E), lower maximum stress (sigma(max)), and higher elongation at break (epsilon(B)) as determined at 70 degrees C. Polymer networks from 8 kDa star-shaped precursors exhibited poor elasticity when synthesized in the melt, but can be established as stretchable materials with a semi-crystalline morphology, a high gel-content, and a high elongation at break when prepared in solution. Conclusions: The crosslinking condition of methacrylate functionalized precursors significantly affected network properties. For some types of precursors such as star-shaped telechelics, synthesis in solution provided semi-crystalline elastic materials that were not accessible from crosslinking in melt.}, language = {en} } @article{GhobadiHeuchelKratzetal.2012, author = {Ghobadi, Ehsan and Heuchel, Matthias and Kratz, Karl and Lendlein, Andreas}, title = {Influence of different heating regimes on the shape-recovery behavior of poly(L-lactide) in simulated thermomechanical tests}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10440}, pages = {259 -- 264}, year = {2012}, abstract = {Aim: Multifunctional polymer-based biomaterials, which combine degradability with a shape-memory capability and in this way enable the design of actively moving implants such as self-anchoring implants or controlled release systems, have been recently introduced. Of particular interest are approved degradable polymers such as poly(L-lactide) (PLLA), which can be easily functionalized with a shape-memory effect. In the case of semicrystalline PLLA, the glass transition can be utilized as shape-memory switching domain. Methods: In this work we applied a fully atomistic molecular dynamics simulation to study the shape-memory behavior of PLLA. A heating-deformation-cooling programming procedure was applied to atomistic PLLA packing models followed by a recovery module under stress-free conditions allowing the shape recovery. The recovery was simulated by heating the samples from T-low = 250 K to T-high = 500 K with different heating rates beta of 125, 40 and 4 K.ns(-1). Results: We could demonstrate that the obtained strain recovery rate (R-r) was strongly influenced by the applied simulation time and heating rate, whereby R-r values in the range from 46\% to 63\% were achieved. On its own the application of a heating rate of 4 K.ns(-1) enabled us to determine a characteristic switching temperature of T-sw = 473 K for the modeled samples. Conclusions: We anticipate that the atomistic modeling approach presented should be capable of enabling further study of T-sw with respect to the molecular structure of the investigated SMP and therefore could be applied in the context of design and development of new shape-memory (bio) materials.}, language = {en} } @article{TartivelBehlSchroeteretal.2012, author = {Tartivel, Lucile and Behl, Marc and Schr{\"o}ter, Michael and Lendlein, Andreas}, title = {Hydrogel networks based on ABA triblock copolymers}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10295}, pages = {243 -- 248}, year = {2012}, abstract = {Background: Triblock copolymers from hydrophilic oligo(ethylene glycol) segment A and oligo(propylene glycol) segment B, providing an ABA structure (OEG-OPG-OEG triblock), are known to be biocompatible and are used as self-solidifying gels in drug depots. A complete removal of these depots would be helpful in cases of undesired side effects of a drug, but this remains a challenge as they liquefy below their transition temperature. Therefore we describe the synthesis of covalently cross-linked hydrogel networks. Method: Triblock copolymer-based hydrogels were created by irradiating aqueous solutions of the corresponding macro-dimethacrylates with UV light. The degree of swelling, swelling kinetics, mechanical properties and morphology of the networks were investigated. Results: Depending on precursor concentration, equilibrium degree of swelling of the films ranged between 500\% and 880\% and was reached in 1 hour. In addition, values for storage and loss moduli of the hydrogel networks were in the 100 Pa to 10 kPa range. Conclusion: Although OEG-OPG-OEG triblocks are known for their micellization, which could hamper polymer network formation, reactive OEG-OPG-OEG triblock oligomers could be successfully polymerized into hydrogel networks. The degree of swelling of these hydrogels depends on their molecular weight and on the oligomer concentration used for hydrogel preparation. In combination with the temperature sensitivity of the ABA triblock copolymers, it is assumed that such hydrogels might be beneficial for future medical applications -e.g., removable drug release systems.}, language = {en} } @article{vonRuestenLangeLuetzowNeffeetal.2012, author = {von R{\"u}sten-Lange, Maik and Luetzow, Karola and Neffe, Axel T. and Lendlein, Andreas}, title = {Characterization of oligo(ethylene glycol) and oligoglycerol functionalized poly(ether imide) by angle-dependent X-ray photoelectron spectroscopy}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10345}, pages = {215 -- 222}, year = {2012}, abstract = {Purpose: Previous investigations have shown that poly(ether imide) (PEI) membranes can be functionalized with aminated macromolecules. In this study we explored whether the characterization of PEI functionalized with oligo(ethylene glycol) (OEG) or linear, side chain methylated oligoglycerols (OGMe), by angle-dependent X-ray induced photoelectron spectroscopy (XPS) can be used to prove the functionalization, give insight into the reaction mechanism and reveal the spatial distribution of the grafts. Methods: PEI membranes were functionalized under alkaline conditions using an aqueous solution with 2 wt\% of alpha-amino-methoxy oligo(ethylene glycol) (M-n = 1,320 g.mol(-1)) or linear, side chain methylated monoamine oligoglycerols (M-n = 1,120, 1,800 or 2,270 g.mol(-1)), respectively. The functionalized membranes were investigated using XPS measurements at different detector angles to enable comparison between the signals related to the bulk and surface volume and were compared with untreated and alkaline-treated PEI membranes. Results: While at a perpendicular detector angle the bulk signals of the PEI were prominent, at larger surface volume-related detector angles, the signals for OGMe and OEG were determinable. Conclusion: The surface functionalization of PEI with OEG and OGMe could be verified by the angle-dependent XPS. The observations proved the functionalization at the PEI surface, as the polyethers were detected at angles providing signals of the surface volume. Furthermore, the chemical functions determined verified a covalent binding via the nucleophilic addition of the amine functionalized OGMe and OEG to the PEI imide function.}, language = {en} } @article{WangHeuchelFangetal.2012, author = {Wang, Li and Heuchel, Matthias and Fang, Liang and Kratz, Karl and Lendlein, Andreas}, title = {Influence of a polyester coating of magnetic nanoparticles on magnetic heating behavior of shape-memory polymer-based composites}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10293}, pages = {203 -- 209}, year = {2012}, abstract = {Background: Magnetic composites of thermosensitive shape-memory polymers (SMPs) and magnetite nanoparticles (MNPs) allow noncontact actuation of the shape-memory effect in an alternating magnetic field. In this study, we investigated whether the magnetic heating capability of cross-linked poly(epsilon-caprolactone)/MNP composites (cPCLC) could be improved by covalent coating of MNPs with oligo(epsilon-caprolactone) (OCL). Methods: Two different types of cPCLC containing uncoated and OCL-coated MNP with identical magnetite weight content were prepared by thermally induced polymerization of poly(epsilon-caprolactone) diisocyanatoethyl methacrylate. Both cPCLCs exhibited a melting transition at T-m = 48 degrees C, which could be used as switching transition. Results: The dispersion of the embedded nanoparticles within the polymer matrix could be substantially improved, when the OCL-coated MNPs were used, as visualized by scanning electron microscopy. We could further demonstrate that in this way the maximal achievable bulk temperature (T-bulk) obtained within the cPCLC test specimen in magnetic heating experiments at a magnetic field strength of H = 30 kA.m(-1) could be increased from T bulk = 48 degrees C to T bulk = 74 degrees C.}, language = {en} } @article{MelchertYongvongsoontornBehletal.2012, author = {Melchert, Christian and Yongvongsoontorn, Nunnarpas and Behl, Marc and Lendlein, Andreas}, title = {Synthesis and characterization of telechelic oligoethers with terminal cinnamylidene acetic acid moieties}, series = {Journal of applied biomaterials \& functional materials}, volume = {10}, journal = {Journal of applied biomaterials \& functional materials}, number = {3}, publisher = {Wichtig}, address = {Milano}, issn = {2280-8000}, doi = {10.5301/JABFM.2012.10364}, pages = {185 -- 190}, year = {2012}, abstract = {Purpose: The formation of photoresponsive hydrogels were reported by irradiation of star-shaped poly(ethylene glycol)s with terminal cinnamylidene acetic acid (CAA) groups, which are capable of a photoinduced [2+2] cycloaddition. In this study we explored whether oligo(ethylene glycol) s and oligo(propylene glycol)s of varying molecular architecture (linear or star-shaped) or molecular weights could be functionalized with CAA as terminal groups by esterification or by amide formation. Methods: Oligo(ethylene glycol) (OEG) and oligo(propylene glycol) (OPG) with varying molecular architecture (linear, star-shaped) and weight average molecular weights between 1000 and 5000 g.mol(-1) were functionalized by means of esterification of hydroxyl or amine endgroups with cinnamylidene acetic acid (CAA) or cinnamylidene acetyl chloride (CAC) as telechelic endgroups. The chemical structure, thermal properties, and molecular weights of the oligoethers obtained were determined by NMR spectroscopy, UV spectroscopy, DSC, and MALDI-TOF. Results: CAA-functionalized linear and star-shaped OEGs or OPGs could be obtained with a degree of functionalization higher than 90\%. In MALDI-TOF measurements an increase in Mw of about 150 g.mol(-1) (for each terminal end) after the functionalization reaction was observed. OEGCAA and OPGCAA showed an increase in glass transition temperature (T-g) from about -70 degrees C to -50 degrees C, compared to the unfunctionalized oligoethers. In addition, the melting temperature (T-m) of OEGCAA decreased from about 55 C to 30 degrees C, which can be accounted for by the hampered crystallization of the precursors because of the bulky CAA end groups as well as by the loss of the hydroxyl telechelic end groups. Conclusion: The synthesis of photoresponsive oligoethers containing cinnamylidene acetic acid as telechelic endgroup was reported and high degrees of functionalization could be achieved. Such photosensitive oligomers are promising candidates as reactive precursors, for the preparation of biocompatible high molecular weight polymers and polymer networks.}, language = {en} } @article{SchmidtSchippersWelkeretal.2012, author = {Schmidt, Romy and Schippers, Jos H. M. and Welker, Annelie and Mieulet, Delphine and Guiderdoni, Emmanuel and M{\"u}ller-R{\"o}ber, Bernd}, title = {Transcription factor OsHsfC1b regulates salt tolerance and development in Oryza sativa ssp japonica}, series = {AoB PLANTS}, journal = {AoB PLANTS}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {2041-2851}, doi = {10.1093/aobpla/pls011}, pages = {17}, year = {2012}, abstract = {Background and aims Salt stress leads to attenuated growth and productivity in rice. Transcription factors like heat shock factors (HSFs) represent central regulators of stress adaptation. Heat shock factors of the classes A and B are well established as regulators of thermal and non-thermal stress responses in plants; however, the role of class C HSFs is unknown. Here we characterized the function of the OsHsfC1b (Os01g53220) transcription factor from rice. Methodology We analysed the expression of OsHsfC1b in the rice japonica cultivars Dongjin and Nipponbare exposed to salt stress as well as after mannitol, abscisic acid (ABA) and H2O2 treatment. For functional characterization of OsHsfC1b, we analysed the physiological response of a T-DNA insertion line (hsfc1b) and two artificial micro-RNA (amiRNA) knock-down lines to salt, mannitol and ABA treatment. In addition, we quantified the expression of small Heat Shock Protein (sHSP) genes and those related to signalling and ion homeostasis by quantitative real-time polymerase chain reaction in roots exposed to salt. The subcellular localization of OsHsfC1b protein fused to green fluorescent protein (GFP) was determined in Arabidopsis mesophyll cell protoplasts. Principal results Expression of OsHsfC1b was induced by salt, mannitol and ABA, but not by H2O2. Impaired function of OsHsfC1b in the hsfc1b mutant and the amiRNA lines led to decreased salt and osmotic stress tolerance, increased sensitivity to ABA, and temporal misregulation of salt-responsive genes involved in signalling and ion homeostasis. Furthermore, sHSP genes showed enhanced expression in knock-down plants under salt stress. We observed retarded growth of hsfc1b and knock-down lines in comparison with control plants under non-stress conditions. Transient expression of OsHsfC1b fused to GFP in protoplasts revealed nuclear localization of the transcription factor. Conclusions OsHsfC1b plays a role in ABA-mediated salt stress tolerance in rice. Furthermore, OsHsfC1b is involved in the response to osmotic stress and is required for plant growth under non-stress conditions.}, language = {en} } @article{HundertmarkPopovaRauschetal.2012, author = {Hundertmark, Michaela and Popova, Antoaneta V. and Rausch, Saskia and Seckler, Robert and Hincha, Dirk K.}, title = {Influence of drying on the secondary structure of intrinsically disordered and globular proteins}, series = {Biochemical and biophysical research communications}, volume = {417}, journal = {Biochemical and biophysical research communications}, number = {1}, publisher = {Elsevier}, address = {San Diego}, issn = {0006-291X}, doi = {10.1016/j.bbrc.2011.11.067}, pages = {122 -- 128}, year = {2012}, abstract = {Circular dichroism (CD) spectroscopy of five Arabidopsis late embryogenesis abundant (LEA) proteins constituting the plant specific families LEA_5 and LEA_6 showed that they are intrinsically disordered in solution and partially fold during drying. Structural predictions were comparable to these results for hydrated LEA_6, but not for LEA_5 proteins. FTIR spectroscopy showed that verbascose, but not sucrose, strongly affected the structure of the dry proteins. The four investigated globular proteins were only mildly affected by drying in the absence, but strongly in the presence of sugars. These data highlight the larger structural flexibility of disordered compared to globular proteins and the impact of sugars on the structure of both disordered and globular proteins during drying.}, language = {en} } @article{HerzogSchickLeitenbergeretal.2012, author = {Herzog, Marc and Schick, Daniel and Leitenberger, Wolfram and Shayduk, Roman and van der Veen, Renske M. and Milne, Christopher J. and Johnson, Steven Lee and Vrejoiu, Ionela and Bargheer, Matias}, title = {Tailoring interference and nonlinear manipulation of femtosecond x-rays}, series = {New journal of physics : the open-access journal for physics}, volume = {14}, journal = {New journal of physics : the open-access journal for physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1367-2630}, doi = {10.1088/1367-2630/14/1/013004}, pages = {9}, year = {2012}, abstract = {We present ultrafast x-ray diffraction (UXRD) experiments on different photoexcited oxide superlattices. All data are successfully simulated by dynamical x-ray diffraction calculations based on a microscopic model, that accounts for the linear response of phonons to the excitation laser pulse. Some Bragg reflections display a highly nonlinear strain dependence. The origin of linear and two distinct nonlinear response phenomena is discussed in a conceptually simpler model using the interference of envelope functions that describe the diffraction efficiency of the average constituent nanolayers. The combination of both models facilitates rapid and accurate simulations of UXRD experiments.}, language = {en} } @article{ShainyanKleinpeter2012, author = {Shainyan, Bagrat A. and Kleinpeter, Erich}, title = {Conformational preferences of Si-Ph,H and Si-Ph,Me silacyclohexanes and 1,3-thiasilacyclohexanes. Additivity of conformational energies in 1,1-disubstituted heterocyclohexanes}, series = {Tetrahedron}, volume = {68}, journal = {Tetrahedron}, number = {1}, publisher = {Elsevier}, address = {Oxford}, issn = {0040-4020}, doi = {10.1016/j.tet.2011.10.082}, pages = {114 -- 125}, year = {2012}, abstract = {The conformational equilibria of 1-phenyl-1-silacyclohexane 1, 3-phenyl-1,3-thiasilacyclohexane 2, 1-methyl-1-phenyl-1-silacyclohexane 3, and 3-methyl-3-phenyl-1,3-thiasilacyclohexane 4 have been studied for the first time by low temperature C-13 NMR spectroscopy at 103 K. Predominance of the equatorial conformer of compound 1 (Ph-eq/Ph-ax=78\%:22\%) is much less than in its carbon analog, phenylcyclohexane (nearly 100\% of Ph-eq). And in contrast to 1-methyl-1-phenylcyclohexane, the conformers with the equatorial Ph group are predominant for compounds 3 and 4: at 103 K, Ph-eq/Ph-ax ratios are 63\%:37\% (3) and 68\%:32\% (4). As the Si-C bonds are elongated with respect to C-C bonds, the barriers to ring inversion are only between 5.2-6.0 (ax -> eq) and 5.4-6.0 (eq -> ax) kcal mol(-1). Parallel calculations at the DFT and MP2 level of theory (as well as the G2 calculations for compound 1) show qualitative agreement with the experiment. The additivity/nonadditivity of conformational energies of substituents on cyclohexane and silacyclohexane derivatives is analyzed. The geminally disubstituted cyclohexanes containing a phenyl group show large deviations from additivity, whereas in 1-methyl-1-phenyl-1-silacyclohexane and 3-methyl-3-phenyl-1,3-thiasilacyclohexane the effects of the methyl and phenyl groups are almost additive. The reasons for the different conformational preferences in carbocyclic and heterocyclic compounds are analyzed using the homodesmotic reactions approach.}, language = {en} } @article{Tonita2012, author = {Tonita, Aaryn}, title = {Distributional sources for black hole initial data}, series = {Classical and quantum gravit}, volume = {29}, journal = {Classical and quantum gravit}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0264-9381}, doi = {10.1088/0264-9381/29/1/015001}, pages = {16}, year = {2012}, abstract = {Black hole initial data are usually produced using Bowen-York-type puncture initial data or by applying an excision boundary condition. The benefits of the Bowen-York initial data are the ability to specify the spin and momentum of the system as parameters of the initial data. In an attempt to extend these benefits to other formulations of the Einstein constraints, the puncture method is reformulated using distributions as source terms. It is shown how the Bowen-York puncture black hole initial data and the trumpet variation are generated by distributional sources. A heuristic argument is presented to argue that these sources are the general sources of spin and momentum. In order to clarify the meaning of other distributional sources, an exact family of initial data with generalized sources to the Hamiltonian constraint are studied; spinning trumpet black hole initial data and black hole initial data with higher order momentum sources are also studied.}, language = {en} } @article{GuljamowDelissenBaumannetal.2012, author = {Guljamow, Arthur and Delissen, Friedmar and Baumann, Otto and Thuenemann, Andreas F. and Dittmann-Th{\"u}nemann, Elke}, title = {Unique properties of eukaryote-type actin and profilin horizontally transferred to cyanobacteria}, series = {PLoS one}, volume = {7}, journal = {PLoS one}, number = {1}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0029926}, pages = {221 -- 231}, year = {2012}, abstract = {A eukaryote-type actin and its binding protein profilin encoded on a genomic island in the cyanobacterium Microcystis aeruginosa PCC 7806 co-localize to form a hollow, spherical enclosure occupying a considerable intracellular space as shown by in vivo fluorescence microscopy. Biochemical and biophysical characterization reveals key differences between these proteins and their eukaryotic homologs. Small-angle X-ray scattering shows that the actin assembles into elongated, filamentous polymers which can be visualized microscopically with fluorescent phalloidin. Whereas rabbit actin forms thin cylindrical filaments about 100 mu m in length, cyanobacterial actin polymers resemble a ribbon, arrest polymerization at 510 lam and tend to form irregular multi-strand assemblies. While eukaryotic profilin is a specific actin monomer binding protein, cyanobacterial profilin shows the unprecedented property of decorating actin filaments. Electron micrographs show that cyanobacterial profilin stimulates actin filament bundling and stabilizes their lateral alignment into heteropolymeric sheets from which the observed hollow enclosure may be formed. We hypothesize that adaptation to the confined space of a bacterial cell devoid of binding proteins usually regulating actin polymerization in eukaryotes has driven the co-evolution of cyanobacterial actin and profilin, giving rise to an intracellular entity.}, language = {en} } @article{CampbellEisert2012, author = {Campbell, Earl T. and Eisert, Jens}, title = {Gaussification and entanglement distillation of continuous-variable systems a unifying picture}, series = {Physical review letters}, volume = {108}, journal = {Physical review letters}, number = {2}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.108.020501}, pages = {5}, year = {2012}, abstract = {Distillation of entanglement using only Gaussian operations is an important primitive in quantum communication, quantum repeater architectures, and distributed quantum computing. Existing distillation protocols for continuous degrees of freedom are only known to converge to a Gaussian state when measurements yield precisely the vacuum outcome. In sharp contrast, non-Gaussian states can be deterministically converted into Gaussian states while preserving their second moments, albeit by usually reducing their degree of entanglement. In this work-based on a novel instance of a noncommutative central limit theorem-we introduce a picture general enough to encompass the known protocols leading to Gaussian states, and new classes of protocols including multipartite distillation. This gives the experimental option of balancing the merits of success probability against entanglement produced.}, language = {en} } @article{KneisBuergerBronstert2012, author = {Kneis, David and Buerger, Gerd and Bronstert, Axel}, title = {Evaluation of medium-range runoff forecasts for a 50 km(2) watershed}, series = {Journal of hydrology}, volume = {414}, journal = {Journal of hydrology}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2011.11.005}, pages = {341 -- 353}, year = {2012}, abstract = {We generated medium-range forecasts of runoff for a 50 km(2) headwater catchment upstream of a reservoir using numerical weather predictions (NWPs) of the past as input to an operational hydrological model. NWP data originating from different sources were tested. For a period of 8.5 years, we computed daily forecasts with a lead time of +120 h based on an empirically downscaled version of the ECMWF's ensemble prediction system. For the last 3.5 years of the test period, we also tried the deterministic COSMO-EU forecast disseminated by the German Weather Service for lead times of up to +72 h. Common measures of skill indicate superiority of the ensemble runoff forecast over single-value forecasts for longer lead times. However, regardless of which NWP data were being used, the probability of event detection (POD) was found to be generally lower than 50\%. In many cases, values in the range of 20-30\% were obtained. At the same time, the false alarms ratio (FAR) was often found to be considerably high. The observed uncertainties in the hydrological forecasts were shown to originate from both the insufficient quality of precipitation forecasts as well as deficiencies in hydrological modeling and quantitative precipitation estimation. With respect to the anticipatory control of reservoirs in the studied catchment, the value of the tested runoff forecasts appears to be limited. This is due to the unfavorably low POD/FAR ratio in conjunction with a high cost-loss ratio. However, our results indicate that, in many cases, major runoff events related to snow melt can be successfully predicted as early as 4-5 days in advance.}, language = {en} } @article{ShainyanKirpichenkoShlykovetal.2012, author = {Shainyan, Bagrat A. and Kirpichenko, Svetlana V. and Shlykov, Sergei A. and Keinpeter, Erich}, title = {Structure and conformational properties of 1,3,3-Trimethyl-1,3-Azasilinane gas electron diffraction, dynamic NMR, and theoretical study}, series = {The journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment \& general theory}, volume = {116}, journal = {The journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment \& general theory}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {1089-5639}, doi = {10.1021/jp2110852}, pages = {784 -- 789}, year = {2012}, abstract = {Structure and the conformational properties of 1,3,3-trimethyl-1,3-azasilinane have been studied. According to gas electron diffraction (GED), the molecule exists in a slightly distorted chair conformation with the N-Me group in equatorial position. High-level quantum chemical calculations excellently, reproduce the experimental geometry. Employing variable temperature H-1 and C-13 NMR spectroscopy down to 103 K, the conformational equilibrium could be frozen and the barrier to ring inversion determined.}, language = {en} } @article{BommGuenterStumpe2012, author = {Bomm, Jana and G{\"u}nter, Christina and Stumpe, Joachim}, title = {Synthesis and optical characterization of thermosensitive, luminescent gold nanodots}, series = {The journal of physical chemistry : C, Nanomaterials and interfaces}, volume = {116}, journal = {The journal of physical chemistry : C, Nanomaterials and interfaces}, number = {1}, publisher = {American Chemical Society}, address = {Washington}, issn = {1932-7447}, doi = {10.1021/jp206260r}, pages = {81 -- 85}, year = {2012}, abstract = {A facile one-pot synthesis for preparing thermosensitive, luminescent gold nanodots with diameters of 1-2 nm is presented. The influence of the alkyl chain length of the surface ligands (alkyl thiols) on the optical properties of the gold nanodots was investigated. The synthesized gold nanodots show strong thermosensitive photoluminescence. A photoluminescence quantum yield of 16.6\% was observed at room temperature, which could be improved to a value of 28.6\% when cooling the gold nanodot solutions to -7 degrees C. The synthesized thermosensitive, luminescent gold nanodots are interesting candidates for optoelectronic devices, medical imaging, sensing, or security labels.}, language = {en} } @article{GrudenHrenHermanetal.2012, author = {Gruden, Kristina and Hren, Matjaz and Herman, Ana and Blejec, Andrej and Albrecht, Tanja and Selbig, Joachim and Bauer, Christian G. and Schuchardt, Johannes and Or-Guil, Michal and Zupancic, Klemen and Svajger, Urban and Stabuc, Borut and Ihan, Alojz and Kopitar, Andreja Natasa and Ravnikar, Maja and Knezevic, Miomir and Rozman, Primoz and Jeras, Matjaz}, title = {A "Crossomics" study analysing variability of different components in peripheral blood of healthy caucasoid individuals}, series = {PLoS one}, volume = {7}, journal = {PLoS one}, number = {1}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0028761}, pages = {12}, year = {2012}, abstract = {Background: Different immunotherapy approaches for the treatment of cancer and autoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex "crossomics'' analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4(+)T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20\% of metabolites and less than 10\% of genes, were identified as highly variable in our dataset. Conclusions/Significance: Our study shows that the intra- individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective.}, language = {en} } @article{HinzLehnhardtZakrzewskietal.2012, author = {Hinz, Justyna and Lehnhardt, Lothar and Zakrzewski, Silke and Zhang, Gong and Ignatova, Zoya}, title = {Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophy}, series = {The journal of biological chemistry}, volume = {287}, journal = {The journal of biological chemistry}, number = {3}, publisher = {American Society for Biochemistry and Molecular Biology}, address = {Bethesda}, issn = {0021-9258}, doi = {10.1074/jbc.M111.318915}, pages = {2068 -- 2078}, year = {2012}, abstract = {Preferential accumulation of mutant proteins in the nucleus has been suggested to be the molecular culprit that confers cellular toxicity in the neurodegenerative disorders caused by polyglutamine (polyQ) expansion. Here, we use dynamic imaging approaches, orthogonal cross-seeding, and composition analysis to examine the dynamics and structure of nuclear and cytoplasmic inclusions of atrophin-1, implicated in dentatorubropallidoluysian atrophy, a polyQ-based disease with complex clinical features. Our results reveal a large heterogeneity in the dynamics of the nuclear inclusions compared with the compact and immobile cytoplasmic aggregates. At least two types of inclusions of expanded atrophin-1 with different mobility of the molecular species and ability to exchange with the surrounding monomer pool coexist in the nucleus. Intriguingly, the enrichment of nuclear inclusions with slow dynamics parallels changes in the aggregate core architecture that are dominated by the polyQ stretch. We propose that the observed complexity in the dynamics of the nuclear inclusions provides a molecular explanation for the enhanced cellular toxicity of the nuclear aggregates in polyQ-based neurodegeneration.}, language = {en} } @article{KruegerBatsiosBaumannetal.2012, author = {Kr{\"u}ger, Anne and Batsios, Petros and Baumann, Otto and Luckert, Eva and Schwarz, Heinz and Stick, Reimer and Meyer, Irene and Gr{\"a}f, Ralph}, title = {Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism}, series = {Molecular biology of the cell : the official publication of the American Society for Cell Biology}, volume = {23}, journal = {Molecular biology of the cell : the official publication of the American Society for Cell Biology}, number = {2}, publisher = {American Society for Cell Biology}, address = {Bethesda}, issn = {1059-1524}, doi = {10.1091/mbc.E11-07-0595}, pages = {360 -- 370}, year = {2012}, abstract = {Lamins build the nuclear lamina and are required for chromatin organization, gene expression, cell cycle progression, and mechanical stabilization. Despite these universal functions, lamins have so far been found only in metazoans. We have identified protein NE81 in Dictyostelium, which has properties that justify its denomination as a lamin-like protein in a lower eukaryote. This is based on its primary structure, subcellular localization, and regulation during mitosis, and its requirement of the C-terminal CaaX box as a posttranslational processing signal for proper localization. Our knockout and overexpression mutants revealed an important role for NE81 in nuclear integrity, chromatin organization, and mechanical stability of cells. All our results are in agreement with a role for NE81 in formation of a nuclear lamina. This function is corroborated by localization of Dictyostelium NE81 at the nuclear envelope in human cells. The discovery of a lamin-like protein in a unicellular organism is not only intriguing in light of evolution, it may also provide a simple experimental platform for studies of the molecular basis of laminopathies.}, language = {en} } @article{KizilirmakRoeslerKhader2012, author = {Kizilirmak, J. M. and R{\"o}sler, Frank and Khader, P. H.}, title = {Control processes during selective long-term memory retrieval}, series = {NeuroImage : a journal of brain function}, volume = {59}, journal = {NeuroImage : a journal of brain function}, number = {2}, publisher = {Elsevier}, address = {San Diego}, issn = {1053-8119}, doi = {10.1016/j.neuroimage.2011.08.041}, pages = {1830 -- 1841}, year = {2012}, abstract = {In our daily life, we often need to selectively remember information related to the same retrieval cue in a consecutive manner (e.g., ingredients from a recipe). To investigate such selection processes during cued long-term memory (LTM) retrieval, we used a paradigm in which the retrieval demands were systematically varied from trial to trial and analyzed, by means of behavior and slow cortical EEG potentials (SCPs), the retrieval processes in the current trial depending on those of the previous trial. We varied whether the retrieval cue, the type of to-be-retrieved association (feature), or retrieval load was repeated or changed from trial to trial. The behavioral data revealed a benefit of feature repetition, probably due to trial-by-trial feature priming. SCPs further showed an effect of cue change with a mid-frontal maximum, suggesting increased control demands when the cue was repeated, as well as a parietal effect of retrieval-load change, indicating increased activation of posterior neural resources when focusing on a single association after all learned associations had been activated previously, compared to staying with single associations across trials. These effects suggest the existence of two distinct types of dynamic (trial-by-trial) control processes during LTM retrieval: (1) medial frontal processes that monitor or regulate interference within a set of activated associations, and (2) posterior processes regulating attention to LTM representations. The present study demonstrates that processes mediating selective LTM retrieval can be successfully studied by manipulating the history of processing demands in trial sequences.}, language = {en} }