@article{IhlenburgMaiThuenemannetal.2021,
  author    = {Ihlenburg, Ramona and Mai, Tobias and Th{\"u}nemann, Andreas F. and Baerenwald, Ruth and Saalw{\"a}chter, Kay and Koetz, Joachim and Taubert, Andreas},
  title     = {Sulfobetaine hydrogels with a complex multilength-scale hierarchical structure},
  series = {The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces \& biophysical chemistry},
  volume    = {125},
  journal   = {The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces \& biophysical chemistry},
  number    = {13},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1520-6106},
  doi       = {10.1021/acs.jpcb.0c10601},
  pages     = {3398 -- 3408},
  year      = {2021},
  abstract  = {Hydrogels with a hierarchical structure were prepared from a new highly water-soluble crosslinker N,N,N',N'-tetramethyl-N,N'-bis(2-ethylmethacrylate)-propyl-1,3-diammonium dibromide and from the sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate. The free radical polymerization of the two compounds is rapid and yields near-transparent hydrogels with sizes up to 5 cm in diameter. Rheology shows a clear correlation between the monomer-to-crosslinker ratio and the storage and loss moduli of the hydrogels. Cryo-scanning electron microscopy, low-field nuclear magnetic resonance (NMR) spectroscopy, and small-angle X-ray scattering show that the gels have a hierarchical structure with features spanning the nanometer to the sub-millimeter scale. The NMR study is challenged by the marked inhomogeneity of the gels and the complex chemical structure of the sulfobetaine monomer. NMR spectroscopy shows how these complications can be addressed via a novel fitting approach that considers the mobility gradient along the side chain of methacrylate-based monomers.},
  language  = {en}
}
@phdthesis{Mai2016,
  author    = {Mai, Tobias},
  title     = {Polymerunterst{\"u}tzte Calciumphosphatmineralisation},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-89056},
  school      = {Universit{\"a}t Potsdam},
  year      = {2016},
  abstract  = {Im Verlauf dieser Arbeit sind Blockcopolymere verschiedener Ladung auf Basis von PEO mit hohen Molekulargewichten durch lebendende freie radikalische Polymerisation hergestellt worden. Die Polymere sind einfach im Grammmaßstab herstellbar. Sie zeigen sowohl einen großen Einfluss auf die Nukleation als auch auf die Aufl{\"o}sung von Calciumphosphat. Gleichwohl scheint das Vorhandensein von positiven Gruppen (Kationen, Ampholyten und Betainen) keinen dramatischen Einfluss auf die Nukleation zu haben. So verursachen Polymere mit positiven Ladungen die gleiche Retentionwirkung wie solche, die ausschließlich anionische Gruppen enthalten. Aus der Verwendung der kationischen, ampholytischen und betainischen Copolymere resultiert allerdings eine andersartige Morphologie der Niederschl{\"a}ge, als aus der Verwendung der Anionischen hervorgeht. Bei der Stabilisierung einer HAP-Oberfl{\"a}che setzt sich dieser Trend fort, das heißt, rein anionische Copolymere wirken st{\"a}rker stabilisierend als solche, die positive Ladungen enthalten. Durch Inkubation von menschlichem Zahnschmelz mit anionischen Copolymeren konnte gezeigt werden, dass die Biofilmbildung verglichen mit einer unbehandelten Zahnoberfl{\"a}che eingeschr{\"a}nkt abl{\"a}uft. All dies macht die Polymere zu interessanten Additiven f{\"u}r Zahnpflegeprodukte. Zus{\"a}tzlich konnten auf Basis dieser rein anionischen Copolymere Polymerb{\"u}rsten, ebenfalls {\"u}ber lebendende freie radikalische Polymerisation, hergestellt werden. Diese zeichnen sich durch einen großen Einfluss auf die Kristallphase aus und bilden mit dem CHAP des AB-Types das Material, welches auch in Knochen und Z{\"a}hnen vorkommt. Erste Cytotoxizit{\"a}tstests lassen auf das große Potential dieser Polymerb{\"u}rsten f{\"u}r Beschichtungen in der Medizintechnik schließen.},
  language  = {de}
}
@article{MaiBoyeYuanetal.2015,
  author    = {Mai, Tobias and Boye, Susanne and Yuan, Jiayin and V{\"o}lkel, Antje and Gr{\"a}wert, Marlies and G{\"u}nter, Christina and Lederer, Albena and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization},
  series = {RSC Advances : an international journal to further the chemical sciences},
  journal   = {RSC Advances : an international journal to further the chemical sciences},
  number    = {5},
  publisher = {RSC Publishing},
  address   = {London},
  issn      = {2046-2069},
  doi       = {10.1039/c5ra20035k},
  pages     = {103494 -- 103505},
  year      = {2015},
  abstract  = {The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium)ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 106 g mol-1. All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100 000 g mol-1). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.},
  language  = {en}
}
@misc{MaiBoyeYuanetal.2015,
  author    = {Mai, Tobias and Boye, Susanne and Yuan, Jiayin and V{\"o}lkel, Antje and Gr{\"a}wert, Marlies and G{\"u}nter, Christina and Lederer, Albena and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-85299},
  year      = {2015},
  abstract  = {The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium)ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 106 g mol-1. All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100 000 g mol-1). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.},
  language  = {en}
}
@article{MaiBoyeYuanetal.2015,
  author    = {Mai, Tobias and Boye, Susanne and Yuan, Jiayin and Voelkel, Antje and Graewert, Marlies and G{\"u}nter, Christina and Lederer, Albena and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization},
  series = {RSC Advances},
  volume    = {5},
  journal   = {RSC Advances},
  number    = {125},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2046-2069},
  doi       = {10.1039/c5ra20035k},
  pages     = {103494 -- 103505},
  year      = {2015},
  abstract  = {The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine) s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium) ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 10(6) g mol(-1). All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal M-n = 100 000 g mol(-1)). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.},
  language  = {en}
}
@article{MaiRakhmatullinaBleeketal.2014,
  author    = {Mai, Tobias and Rakhmatullina, Ekaterina and Bleek, Katrin and Boye, Susanne and Yuan, Jiayin and Voelkel, Antje and Graewert, Marlies and Cheaib, Zeinab and Eick, Sigrun and G{\"u}nter, Christina and Lederer, Albena and Lussi, Adrian and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-b-poly(3-sulfopropyl methacrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition},
  series = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  volume    = {15},
  journal   = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  number    = {11},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1525-7797},
  doi       = {10.1021/bm500888q},
  pages     = {3901 -- 3914},
  year      = {2014},
  abstract  = {Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.},
  language  = {en}
}
@article{MaiWolskiPuciulMalinowskaetal.2018,
  author    = {Mai, Tobias and Wolski, Karol and Puciul-Malinowska, Agnieszka and Kopyshev, Alexey and Gr{\"a}f, Ralph and Bruns, Michael and Zapotoczny, Szczepan and Taubert, Andreas},
  title     = {Anionic polymer brushes for biomimetic calcium phosphate mineralization},
  series = {Polymers},
  volume    = {10},
  journal   = {Polymers},
  number    = {10},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4360},
  doi       = {10.3390/polym10101165},
  pages     = {17},
  year      = {2018},
  abstract  = {This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.},
  language  = {en}
}