@article{JedrusikBodeStudenckaSmolkaetal.2013,
  author    = {Jedrusik-Bode, Monika and Studencka, Maja and Smolka, Christian and Baumann, Tobias and Schmidt, Henning and Kampf, Jan and Paap, Franziska and Martin, Sophie and Tazi, Jamal and M{\"u}ller, Kristian M. and Kr{\"u}ger, Marcus and Braun, Thomas and Bober, Eva},
  title     = {The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals},
  series = {Journal of cell science},
  volume    = {126},
  journal   = {Journal of cell science},
  number    = {22},
  publisher = {Company of Biologists Limited},
  address   = {Cambridge},
  issn      = {0021-9533},
  doi       = {10.1242/jcs.130708},
  pages     = {5166 -- +},
  year      = {2013},
  abstract  = {SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.},
  language  = {en}
}
@article{CescaBraunMaccaferrietal.2013,
  author    = {Cesca, Simone and Braun, Thomas and Maccaferri, Francesco and Passarelli, Luigi and Rivalta, Eleonora and Dahm, Torsten},
  title     = {Source modelling of the M5-6 Emilia-Romagna, Italy, earthquakes (2012 May 20-29)},
  series = {Geophysical journal international},
  volume    = {193},
  journal   = {Geophysical journal international},
  number    = {3},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0956-540X},
  doi       = {10.1093/gji/ggt069},
  pages     = {1658 -- 1672},
  year      = {2013},
  abstract  = {On 2012 May 20 and 29, two damaging earthquakes with magnitudes M-w 6.1 and 5.9, respectively, struck the Emilia-Romagna region in the sedimentary Po Plain, Northern Italy, causing 26 fatalities, significant damage to historical buildings and substantial impact to the economy of the region. The earthquake sequence included four more aftershocks with M-w, >= 5.0, all at shallow depths (about 7-9 km), with similar WNW-ESE striking reverse mechanism. The timeline of the sequence suggests significant static stress interaction between the largest events. We perform here a detailed source inversion, first adopting a point source approximation and considering pure double couple and full moment tensor source models. We compare different extended source inversion approaches for the two largest events, and find that the rupture occurred in both cases along a subhorizontal plane, dipping towards SSW Directivity is well detected for the May 20 main shock, indicating that the rupture propagated unilaterally towards SE. Based on the focal mechanism solution, we further estimate the co-seismic static stress change induced by the May 20 event. By using the rate-and-state model and a Poissonian earthquake occurrence, we infer that the second largest event of May 29 was induced with a probability in the range 0.2-0.4. This suggests that the segment of fault was already prone to rupture. Finally, we estimate peak ground accelerations for the two main events as occurred separately or simultaneously. For the scenario involving hypothetical rupture areas of both main events, we estimate M-w = 6.3 and an increase of ground acceleration by 50 per cent. The approach we propose may help to quantify rapidly which regions are invested by a significant increase of the hazard, bearing the potential for large aftershocks or even a second main shock.},
  language  = {en}
}