@article{ChiarcosDipperGoetzeetal.2008, author = {Chiarcos, Christian and Dipper, Stefanie and G{\"o}tze, Michael and Leser, Ulf and L{\"u}deling, Anke and Ritz, Julia and Stede, Manfred}, title = {A flexible framework for integrating annotations from different tools and tag sets}, issn = {1248-9433}, year = {2008}, abstract = {We present a general framework for integrating annotations from different tools and tag sets. When annotating corpora at multiple linguistic levels, annotators may use different expert tools for different phenomena or types of annotation. These tools employ different data models and accompanying approaches to visualization, and they produce different output formats. For the purposes of uniformly processing these outputs, we developed a pivot format called PAULA, along with converters to and from tool formats. Different annotations are not only integrated at the level of data format, but are also joined on the level of conceptual representation. For this purpose, we introduce OLiA, an ontology of linguistic annotations that mediates between alternative tag sets that cover the same class of linguistic phenomena. All components are integrated in the linguistic information system ANNIS : Annotation tool output is converted to the pivot format PAULA and read into a database where the data can be visualized, queried, and evaluated across multiple layers. For cross-tag set querying and statistical evaluation, ANNIS uses the ontology of linguistic annotations. Finally, ANNIS is also tied to a machine learning component for semiautomatic annotation.}, language = {en} } @article{RoethleinMiettinenIgnatova2015, author = {R{\"o}thlein, Christoph and Miettinen, Markus S. and Ignatova, Zoya}, title = {A flexible approach to assess fluorescence decay functions in complex energy transfer systems}, series = {BMC biophysics}, volume = {8}, journal = {BMC biophysics}, publisher = {BioMed Central}, address = {London}, issn = {2046-1682}, doi = {10.1186/s13628-015-0020-z}, pages = {10}, year = {2015}, abstract = {Background: Time-correlated Forster resonance energy transfer (FRET) probes molecular distances with greater accuracy than intensity-based calculation of FRET efficiency and provides a powerful tool to study biomolecular structure and dynamics. Moreover, time-correlated photon count measurements bear additional information on the variety of donor surroundings allowing more detailed differentiation between distinct structural geometries which are typically inaccessible to general fitting solutions. Results: Here we develop a new approach based on Monte Carlo simulations of time-correlated FRET events to estimate the time-correlated single photon counts (TCSPC) histograms in complex systems. This simulation solution assesses the full statistics of time-correlated photon counts and distance distributions of fluorescently labeled biomolecules. The simulations are consistent with the theoretical predictions of the dye behavior in FRET systems with defined dye distances and measurements of randomly distributed dye solutions. We validate the simulation results using a highly heterogeneous aggregation system and explore the conditions to use this tool in complex systems. Conclusion: This approach is powerful in distinguishing distance distributions in a wide variety of experimental setups, thus providing a versatile tool to accurately distinguish between different structural assemblies in highly complex systems.}, language = {en} } @article{ThomasPfrommerPakmor2021, author = {Thomas, Timon and Pfrommer, Christoph and Pakmor, R{\"u}diger}, title = {A finite volume method for two-moment cosmic ray hydrodynamics on a moving mesh}, series = {Monthly notices of the Royal Astronomical Society}, volume = {503}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stab397}, pages = {2242 -- 2264}, year = {2021}, abstract = {We present a new numerical algorithm to solve the recently derived equations of two-moment cosmic ray hydrodynamics (CRHD). The algorithm is implemented as a module in the moving mesh AREPO code. Therein, the anisotropic transport of cosmic rays (CRs) along magnetic field lines is discretized using a path-conservative finite volume method on the unstructured time-dependent Voronoi mesh of AREPO. The interaction of CRs and gyroresonant Alfven waves is described by short time-scale source terms in the CRHD equations. We employ a custom-made semi-implicit adaptive time stepping source term integrator to accurately integrate this interaction on the small light-crossing time of the anisotropic transport step. Both the transport and the source term integration step are separated from the evolution of the magnetohydrodynamical equations using an operator split approach. The new algorithm is tested with a variety of test problems, including shock tubes, a perpendicular magnetized discontinuity, the hydrodynamic response to a CR overpressure, CR acceleration of a warm cloud, and a CR blast wave, which demonstrate that the coupling between CR and magnetohydrodynamics is robust and accurate. We demonstrate the numerical convergence of the presented scheme using new linear and non-linear analytic solutions.}, language = {en} } @article{BuschMeissnerPotthoffetal.2015, author = {Busch, Jan Philip and Meißner, Tobias and Potthoff, Annegret and Bleyl, Steffen and Georgi, Anett and Mackenzie, Katrin and Trabitzsch, Ralf and Werban, Ulrike and Oswald, Sascha}, title = {A field investigation on transport of carbon-supported nanoscale zero-valent iron (nZVI) in groundwater}, series = {Journal of contaminant hydrology}, volume = {181}, journal = {Journal of contaminant hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0169-7722}, doi = {10.1016/j.jconhyd.2015.03.009}, pages = {59 -- 68}, year = {2015}, abstract = {The application of nanoscale zero-valent iron (nZVI) for subsurface remediation of groundwater contaminants is a promising new technology, which can be understood as alternative to the permeable reactive barrier technique using granular iron. Dechlorination of organic contaminants by zero-valent iron seems promising. Currently, one limitation to widespread deployment is the fast agglomeration and sedimentation of nZVI in colloidal suspensions, even more so when in soils and sediments, which limits the applicability for the treatment of sources and plumes of contamination. Colloid-supported nZVI shows promising characteristics to overcome these limitations. Mobility of Carbo-Iron Colloids (CIC) - a newly developed composite material based on finely ground activated carbon as a carrier for nZVI - was tested in a field application: In this study, a horizontal dipole flow field was established between two wells separated by 53 m in a confined, natural aquifer. The injection/extraction rate was 500 L/h. Approximately 12 kg of CIC was suspended with the polyanionic stabilizer carboxymethyl cellulose. The suspension was introduced into the aquifer at the injection well. Breakthrough of CIC was observed visually and based on total particle and iron concentrations detected in samples from the extraction well. Filtration of water samples revealed a particle breakthrough of about 12\% of the amount introduced. This demonstrates high mobility of CIC particles and we suggest that nZVI carried on CIC can be used for contaminant plume remediation by in-situ formation of reactive barriers. (C) 2015 Elsevier B.V. All rights reserved.}, language = {en} } @article{KrauseBekkeringLindemann2013, author = {Krause, Florian and Bekkering, Harold and Lindemann, Oliver}, title = {A feeling for numbers shared metric for symbolic and tactile numerosities}, series = {Frontiers in psychology}, volume = {4}, journal = {Frontiers in psychology}, number = {3}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2013.00007}, pages = {8}, year = {2013}, abstract = {Evidence for an approximate analog system of numbers has been provided by the finding that the comparison of two numerals takes longer and is more error-prone if the semantic distance between the numbers becomes smaller (so-called numerical distance effect). Recent embodied theories suggest that analog number representations are based on previous sensory experiences and constitute therefore a common magnitude metric shared by multiple domains. Here we demonstrate the existence of a cross-modal semantic distance effect between symbolic and tactile numerosities. Participants received tactile stimulations of different amounts of fingers while reading Arabic digits and indicated verbally whether the amount of stimulated fingers was different from the simultaneously presented digit or not. The larger the semantic distance was between the two numerosities, the faster and more accurate participants made their judgments. This cross-modal numerosity distance effect suggests a direct connection between tactile sensations and the concept of numerical magnitude. A second experiment replicated the interaction between symbolic and tactile numerosities and showed that this effect is not modulated by the participants' finger counting habits. Taken together, our data provide novel evidence for a shared metric for symbolic and tactile numerosities as an instance of an embodied representation of numbers.}, language = {en} } @article{BrothersKoehlerAttermeyeretal.2014, author = {Brothers, Soren M. and Koehler, J. and Attermeyer, Katrin and Grossart, Hans-Peter and Mehner, T. and Meyer, N. and Scharnweber, Inga Kristin and Hilt, Sabine}, title = {A feedback loop links brownification and anoxia in a temperate, shallow lake}, series = {Limnology and oceanography}, volume = {59}, journal = {Limnology and oceanography}, number = {4}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0024-3590}, doi = {10.4319/lo.2014.59.4.1388}, pages = {1388 -- 1398}, year = {2014}, abstract = {This study examines a natural, rapid, fivefold increase in dissolved organic carbon (DOC) concentrations in a temperate shallow lake, describing the processes by which increased DOC resulted in anoxic conditions and altered existing carbon cycling pathways. High precipitation for two consecutive years led to rising water levels and the flooding of adjacent degraded peatlands. Leaching from the flooded soils provided an initial increase in DOC concentrations (from a 2010 mean of 12 +/- 1 mg L-1 to a maximum concentration of 53 mg L-1 by June 2012). Increasing water levels, DOC, and phytoplankton concentrations reduced light reaching the sediment surface, eliminating most benthic primary production and promoting anoxia in the hypolimnion. From January to June 2012 there was a sudden increase in total phosphorus (from 57 mg L-1 to 216 mg L-1), DOC (from 24.6 mg L-1 to 53 mg L-1), and iron (from 0.12 mg L-1 to 1.07 mg L-1) concentrations, without any further large fluxes in water levels. We suggest that anoxic conditions at the sediment surface and flooded soils produced a dramatic release of these chemicals that exacerbated brownification and eutrophication, creating anoxic conditions that persisted roughly 6 months below a water depth of 1 m and extended periodically to the water surface. This brownification-anoxia feedback loop resulted in a near-complete loss of macroinvertebrate and fish populations, and increased surface carbon dioxide (CO2) emissions by an order of magnitude relative to previous years.}, language = {en} } @article{XiaoLiuWangetal.2020, author = {Xiao, Shangbin and Liu, Liu and Wang, Wei and Lorke, Andreas and Woodhouse, Jason Nicholas and Grossart, Hans-Peter}, title = {A Fast-Response Automated Gas Equilibrator (FaRAGE) for continuous in situ measurement of CH4 and CO2 dissolved in water}, series = {Hydrology and earth system sciences : HESS}, volume = {24}, journal = {Hydrology and earth system sciences : HESS}, number = {7}, publisher = {European Geosciences Union (EGU) ; Copernicus}, address = {Munich}, issn = {1027-5606}, doi = {10.5194/hess-24-3871-2020}, pages = {3871 -- 3880}, year = {2020}, abstract = {Biogenic greenhouse gas emissions, e.g., of methane (CH4) and carbon dioxide (CO2) from inland waters, contribute substantially to global warming. In aquatic systems, dissolved greenhouse gases are highly heterogeneous in both space and time. To better understand the biological and physical processes that affect sources and sinks of both CH4 and CO2, their dissolved concentrations need to be measured with high spatial and temporal resolution. To achieve this goal, we developed the Fast-Response Automated Gas Equilibrator (FaRAGE) for real-time in situ measurement of dissolved CH4 and CO2 concentrations at the water surface and in the water column. FaRAGE can achieve an exceptionally short response time (t(95\%) = 12 s when including the response time of the gas analyzer) while retaining an equilibration ratio of 62.6\% and a measurement accuracy of 0.5\% for CH4. A similar performance was observed for dissolved CO2 (t(95\%) = 10 s, equilibration ratio 67.1 \%). An equilibration ratio as high as 91.8\% can be reached at the cost of a slightly increased response time (16 s). The FaRAGE is capable of continuously measuring dissolved CO2 and CH4 concentrations in the nM-to-submM (10(-9)-10(-3) mol L-1) range with a detection limit of subnM (10(-10) mol L-1), when coupling with a cavity ring-down greenhouse gas analyzer (Picarro GasScouter). FaRAGE allows for the possibility of mapping dissolved concentration in a "quasi" three-dimensional manner in lakes and provides an inexpensive alternative to other commercial gas equilibrators. It is simple to operate and suitable for continuous monitoring with a strong tolerance for suspended particles. While the FaRAGE is developed for inland waters, it can be also applied to ocean waters by tuning the gas-water mixing ratio. The FaRAGE is easily adapted to suit other gas analyzers expanding the range of potential applications, including nitrous oxide and isotopic composition of the gases.}, language = {en} } @article{ZieheLaskovNolteetal.2004, author = {Ziehe, Andreas and Laskov, Pavel and Nolte, G and M{\"u}ller, Klaus-Robert}, title = {A fast algorithm for joint diagonalization with non-orthogonal transformations and its application to blind source separation}, year = {2004}, abstract = {A new efficient algorithm is presented for joint diagonalization of several matrices. The algorithm is based on the Frobenius-norm formulation of the joint diagonalization problem, and addresses diagonalization with a general, non- orthogonal transformation. The iterative scheme of the algorithm is based on a multiplicative update which ensures the invertibility of the diagonalizer. The algorithm's efficiency stems from the special approximation of the cost function resulting in a sparse, block-diagonal Hessian to be used in the computation of the quasi-Newton update step. Extensive numerical simulations illustrate the performance of the algorithm and provide a comparison to other leading diagonalization methods. The results of such comparison demonstrate that the proposed algorithm is a viable alternative to existing state-of-the-art joint diagonalization algorithms. The practical use of our algorithm is shown for blind source separation problems}, language = {en} } @article{Lledo1997, author = {Lled{\´o}, Fernando}, title = {A family of examples with quantum constraints}, year = {1997}, language = {en} } @article{DemalHeiseReizetal.2019, author = {Demal, Till Joscha and Heise, Melina and Reiz, Benedikt and Dogra, Deepika and Braenne, Ingrid and Reichenspurner, Hermann and M{\"a}nner, J{\"o}rg and Aherrahrou, Zouhair and Schunkert, Heribert and Erdmann, Jeanette and Abdelilah-Seyfried, Salim}, title = {A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A}, series = {Scientific reports}, volume = {9}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-019-39648-7}, pages = {12}, year = {2019}, abstract = {The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein's anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology.}, language = {en} } @article{Hassler2006, author = {Haßler, Gerda}, title = {A Fala : normalizaci{\´o}n tard{\´i}a e identidad cultural}, year = {2006}, language = {en} } @article{LassGronau2020, author = {Lass, Sander and Gronau, Norbert}, title = {A factory operating system for extending existing factories to Industry 4.0}, series = {Computers in industry : an international, application oriented research journal}, volume = {115}, journal = {Computers in industry : an international, application oriented research journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0166-3615}, doi = {10.1016/j.compind.2019.103128}, pages = {8}, year = {2020}, abstract = {Cyber-physical systems (CPS) have shaped the discussion about Industry 4.0 (I4.0) for some time. To ensure the competitiveness of manufacturing enterprises the vision for the future figures out cyber-physical production systems (CPPS) as a core component of a modern factory. Adaptability and coping with complexity are (among others) potentials of this new generation of production management. The successful transformation of this theoretical construct into practical implementation can only take place with regard to the conditions characterizing the context of a factory. The subject of this contribution is a concept that takes up the brownfield character and describes a solution for extending existing (legacy) systems with CPS capabilities.}, language = {en} } @article{RullensDeligneLaschewskyetal.2005, author = {Rullens, F. and Deligne, N. and Laschewsky, Andr{\´e} and Devillers, M.}, title = {A facile precursor route to transition metal molybdates using a polyzwitterionic matrix bearing simultaneously charged moieties and complexing groups}, issn = {0959-9428}, year = {2005}, abstract = {An unconventional but easily accessible precursor route involving the thermal treatment of hybrid precursors containing an ampholytic polymer matrix is developed to prepare multimetallic oxides of catalytic interest such as transition metal molybdates. A copolymer of diallyldimethylammonium chloride and a functionalized maleamic acid bearing an amine group suited for cation complexation was designed, synthesized and used as a matrix to stabilize inorganic species generated in solution from Ni(NO3)(2)center dot 6H(2)O, Co(NO3)(2)center dot 6H(2)O and/or Mn(NO3)(2)center dot 4H(2)O together with (NH4)(6)Mo(7)O(24)center dot 4H(2)O. UV-vis-NIR as well as C-13-NMR studies suggest that the interactions between the cations and the polymer in solution are mainly electrostatic. Only minor complexation interactions take place under certain conditions. Homogeneous hybrid blends were prepared from these solutions. The presence of a complexing amine group in addition to the charged betaine moieties in the polymer permits stabilization of more than stoichiometric amounts of the metal species in the blends. XRD measurements suggest that the homogeneity in the solid state can be kept up to about 1.5 mol of each metal that is incorporated ( anionic as well as cationic) per mol of repeat units of the copolymer. The blends were calcined under air at 600 degrees C to produce the simple as well as mixed nickel, cobalt and manganese molybdates. Characterization of the final phases by XRD and Raman spectroscopy indicates that the alpha- as well as the beta-molybdate phases can be prepared, and that the mixed structures are solid solutions of the simple NiMoO4, MnMoO4 and CoMoO4. If the precursors engaged are homogeneous, the pH of the precursor solution, the amount of metal that is incorporated in the matrix, and the nature of the polymer matrix seem to exert only a minor influence on the nature of the final phase, which demonstrates the versatility and facile applicability of the method}, language = {en} } @article{HartmanGentzSchilleretal.2018, author = {Hartman, Jan F. and Gentz, Torben and Schiller, Amanda and Greule, Markus and Grossart, Hans-Peter and Ionescu, Danny and Keppler, Frank and Martinez-Cruz, Karla and Sepulveda-Jauregui, Armando and Isenbeck-Schroeter, Margot}, title = {A f ast and sensitive method for the continuous in situ determination of dissolved methane and its delta C-13-isotope ratio in surface waters}, series = {Limnology and Oceanography-methods}, volume = {16}, journal = {Limnology and Oceanography-methods}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {1541-5856}, doi = {10.1002/lom3.10244}, pages = {273 -- 285}, year = {2018}, abstract = {A fast and sensitive method for the continuous determination of methane (CH4) and its stable carbon isotopic values (delta C-13-CH4) in surface waters was developed by applying a vacuum to a gas/liquid exchange membrane and measuring the extracted gases by a portable cavity ring-down spectroscopy analyser (M-CRDS). The M-CRDS was calibrated and characterized for CH4 concentration and delta C-13-CH4 with synthetic water standards. The detection limit of the M-CRDS for the simultaneous determination of CH4 and delta C-13-CH4 is 3.6 nmol L-1 CH4. A measurement precision of CH4 concentrations and delta C-13-CH4 in the range of 1.1\%, respectively, 1.7 parts per thousand (1 sigma) and accuracy (1.3\%, respectively, 0.8 parts per thousand [1 sigma]) was achieved for single measurements and averaging times of 10 min. The response time tau of 57 +/- 5 s allow determination of delta C-13-CH4 values more than twice as fast than other methods. The demonstrated M-CRDS method was applied and tested for Lake Stechlin (Germany) and compared with the headspace-gas chromatography and fast membrane CH4 concentration methods. Maximum CH4 concentrations (577 nmol L-1) and lightest delta C-13-CH4 (-35.2 parts per thousand) were found around the thermocline in depth profile measurements. The M-CRDS-method was in good agreement with other methods. Temporal variations in CH4 concentration and delta C-13-CH4 obtained in 24 h measurements indicate either local methane production/oxidation or physical variations in the thermocline. Therefore, these results illustrate the need of fast and sensitive analyses to achieve a better understanding of different mechanisms and pathways of CH4 formation in aquatic environments.}, language = {en} } @article{Reich2011, author = {Reich, Sebastian}, title = {A dynamical systems framework for intermittent data assimilation}, series = {BIT : numerical mathematics ; the leading applied mathematics journal for all computational mathematicians}, volume = {51}, journal = {BIT : numerical mathematics ; the leading applied mathematics journal for all computational mathematicians}, number = {1}, publisher = {Springer}, address = {Dordrecht}, issn = {0006-3835}, doi = {10.1007/s10543-010-0302-4}, pages = {235 -- 249}, year = {2011}, abstract = {We consider the problem of discrete time filtering (intermittent data assimilation) for differential equation models and discuss methods for its numerical approximation. The focus is on methods based on ensemble/particle techniques and on the ensemble Kalman filter technique in particular. We summarize as well as extend recent work on continuous ensemble Kalman filter formulations, which provide a concise dynamical systems formulation of the combined dynamics-assimilation problem. Possible extensions to fully nonlinear ensemble/particle based filters are also outlined using the framework of optimal transportation theory.}, language = {en} } @article{Strohe1996, author = {Strohe, Hans Gerhard}, title = {A dynamical partial least sqares approach to macroeconometric modelling}, year = {1996}, language = {en} } @article{EngbertLongtinKliegl2002, author = {Engbert, Ralf and Longtin, Andre and Kliegl, Reinhold}, title = {A dynamical model of saccade generation in reading based on spatially distributed lexical processing}, year = {2002}, language = {en} } @article{HaslVoelkleKretschmannetal.2022, author = {Hasl, Andrea and Voelkle, Manuel and Kretschmann, Julia and Richter, Dirk and Brunner, Martin}, title = {A dynamic structural equation approach to modeling wage dynamics and cumulative advantage across the lifespan}, series = {Multivariate Behavioral Research}, volume = {58}, journal = {Multivariate Behavioral Research}, number = {3}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0027-3171}, doi = {10.1080/00273171.2022.2029339}, pages = {504 -- 525}, year = {2022}, abstract = {Wages and wage dynamics directly affect individuals' and families' daily lives. In this article, we show how major theoretical branches of research on wages and inequality-that is, cumulative advantage (CA), human capital theory, and the lifespan perspective-can be integrated into a coherent statistical framework and analyzed with multilevel dynamic structural equation modeling (DSEM). This opens up a new way to empirically investigate the mechanisms that drive growing inequality over time. We demonstrate the new approach by making use of longitudinal, representative U.S. data (NLSY-79). Analyses revealed fundamental between-person differences in both initial wages and autoregressive wage growth rates across the lifespan. Only 0.5\% of the sample experienced a "strict" CA and unbounded wage growth, whereas most individuals revealed logarithmic wage growth over time. Adolescent intelligence and adult educational levels explained substantial heterogeneity in both parameters. We discuss how DSEM may help researchers study CA processes and related developmental dynamics, and we highlight the extensions and limitations of the DSEM framework.}, language = {en} } @article{ThiessenhusenKrivovKruegeretal.2002, author = {Thiessenhusen, Kai-Uwe and Krivov, Alexander V. and Kr{\"u}ger, Harald and Gr{\"u}n, Eberhard}, title = {A dust cloud around Pluto and Charon}, issn = {0032-0633}, year = {2002}, language = {en} } @article{KruegerKrivovGruen2000, author = {Kr{\"u}ger, Harald and Krivov, Alexander V. and Gr{\"u}n, Eberhard}, title = {A dust cloud around Ganymede Maintained by hypervelocity impacts of interplanetary micrometeoroids}, issn = {0032-0633}, year = {2000}, language = {en} } @article{RachKahmenBraueretal.2017, author = {Rach, Oliver and Kahmen, Ansgar and Brauer, Achim and Sachse, Dirk}, title = {A dual-biomarker approach for quantification of changes in relative humidity from sedimentary lipid D/H ratios}, series = {Climate of the past : an interactive open access journal of the European Geosciences Union}, volume = {13}, journal = {Climate of the past : an interactive open access journal of the European Geosciences Union}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1814-9324}, doi = {10.5194/cp-13-741-2017}, pages = {741 -- 757}, year = {2017}, abstract = {Past climatic change can be reconstructed from sedimentary archives by a number of proxies. However, few methods exist to directly estimate hydrological changes and even fewer result in quantitative data, impeding our understanding of the timing, magnitude and mechanisms of hydrological changes. Here we present a novel approach based on delta H-2 values of sedimentary lipid biomarkers in combination with plant physiological modeling to extract quantitative information on past changes in relative humidity. Our initial application to an annually laminated lacustrine sediment sequence from western Europe deposited during the Younger Dryas cold period revealed relative humidity changes of up to 15\% over sub-centennial timescales, leading to major ecosystem changes, in agreement with palynological data from the region. We show that by combining organic geochemical methods and mechanistic plant physiological models on well characterized lacustrine archives it is possible to extract quantitative ecohydrological parameters from sedimentary lipid biomarker delta H-2 data.}, language = {en} } @article{ReifarthBekirBapolisietal.2022, author = {Reifarth, Martin and Bekir, Marek and Bapolisi, Alain M. and Titov, Evgenii and Nusshardt, Fabian and Nowaczyk, Julius and Grigoriev, Dmitry and Sharma, Anjali and Saalfrank, Peter and Santer, Svetlana and Hartlieb, Matthias and B{\"o}ker, Alexander}, title = {A dual pH- and light-responsive spiropyrane-based surfactant}, series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, volume = {61}, journal = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition}, number = {21}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1433-7851}, doi = {10.1002/anie.202114687}, pages = {10}, year = {2022}, abstract = {A cationic surfactant containing a spiropyrane unit is prepared exhibiting a dual-responsive adjustability of its surface-active characteristics. The switching mechanism of the system relies on the reversible conversion of the non-ionic spiropyrane (SP) to a zwitterionic merocyanine (MC) and can be controlled by adjusting the pH value and via light, resulting in a pH-dependent photoactivity: While the compound possesses a pronounced difference in surface activity between both forms under acidic conditions, this behavior is suppressed at a neutral pH level. The underlying switching processes are investigated in detail, and a thermodynamic explanation based on a combination of theoretical and experimental results is provided. This complex stimuli-responsive behavior enables remote-control of colloidal systems. To demonstrate its applicability, the surfactant is utilized for the pH-dependent manipulation of oil-in-water emulsions.}, language = {en} } @article{Trindade2021, author = {Trindade, In{\^e}s}, title = {A drop of immunity}, series = {Molecular plant}, volume = {14}, journal = {Molecular plant}, number = {9}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1674-2052}, doi = {10.1016/j.molp.2021.07.022}, pages = {1437 -- 1438}, year = {2021}, language = {en} } @article{HoieMorgensternGruenwaldetal.2005, author = {Hoie, Lars H. and Morgenstern, E. C. A. and Gr{\"u}nwald, J{\"o}rg and Graubaum, Hans-Joachim and Busch, R. and Luder, W. and Zunft, Hans-Joachim Franz}, title = {A double-blind placebo-controlled clinical trial compares the cholesterollowering effects of two different soy protein preparations in hypercholesterolemic subjects}, issn = {1436-6207}, year = {2005}, abstract = {Background Soy protein is effective in lowering plasma cholesterol, LDL cholesterol and triglyceride concentrations. It has not been conclusively answered, whether and to what extent other soy constituents may also contribute to this effect. Objective To investigate the change in blood lipid levels after application of two soy-based supplements containing soy protein either without (SuproSoy(R)) or with (Abacor(R)) soy fiber and phospholipids in a randomized placebo-controlled triple-armed study. Methods 121 hypercholesterolemic adults ( 66 females, 55 males) were recruited and randomly assigned to one of three treatments. Over 8 weeks they received daily either 25 g soy protein ( as a component of the supplements Abacor(R) or SuproSoy(R)) or 25 g milk protein ( as a component of placebo). Serum lipids were measured at baseline and after 4, 6 and 8 weeks. Results After 8 weeks of supplementation total cholesterol levels were reduced by 8.0 +/- 9.6\% (Abacor(R)) and 3.4 +/- 8.3\% (SuproSoy(R)); LDL cholesterol levels by 9.7 +/- 11.7\% ( Abacor(R)) and 5.4 +/- 11.6\% ( SuproSoy(R)); and Apolipoprotein B levels by 6.9 +/- 14.6\% (Abacor(R)) and 4.0 +/- 12.4 \% (SuproSoy(R)). Serum levels of HDL cholesterol and triglycerides remained unchanged. Conclusions A preparation combining isolated soy protein with soy fibers and phospholipids showed twice the lipid-lowering effect of a preparation containing isolated soy protein alone. Therefore, such soy-based supplements can be useful in reducing the cardiovascular risk}, language = {en} } @article{EcksteinKortePirkeretal.2008, author = {Eckstein, Lars and Korte, Barbara and Pirker, Ulrike and Reinfandt, Christoph}, title = {A divided Kingdom? Reflections on Multi-Ethnic Britain in the New Millenium}, isbn = {978-90-420-2497-7}, year = {2008}, language = {en} } @article{SiepmannBalzerHechtetal.1999, author = {Siepmann, Gerda and Balzer, Hans-Ulrich and Hecht, Karl and Salzberg-Ludwig, Karin}, title = {A disturbance of the circadian thythm or natural activation/deactivation regulation? : a pilot study on a 8- year-old children}, year = {1999}, language = {en} } @article{KaitouaRablMarkl2020, author = {Kaitoua, Abdulrahman and Rabl, Tilmann and Markl, Volker}, title = {A distributed data exchange engine for polystores}, series = {Information technology : methods and applications of informatics and information technology}, volume = {62}, journal = {Information technology : methods and applications of informatics and information technology}, number = {3-4}, publisher = {De Gruyter}, address = {Berlin}, issn = {1611-2776}, doi = {10.1515/itit-2019-0037}, pages = {145 -- 156}, year = {2020}, abstract = {There is an increasing interest in fusing data from heterogeneous sources. Combining data sources increases the utility of existing datasets, generating new information and creating services of higher quality. A central issue in working with heterogeneous sources is data migration: In order to share and process data in different engines, resource intensive and complex movements and transformations between computing engines, services, and stores are necessary. Muses is a distributed, high-performance data migration engine that is able to interconnect distributed data stores by forwarding, transforming, repartitioning, or broadcasting data among distributed engines' instances in a resource-, cost-, and performance-adaptive manner. As such, it performs seamless information sharing across all participating resources in a standard, modular manner. We show an overall improvement of 30 \% for pipelining jobs across multiple engines, even when we count the overhead of Muses in the execution time. This performance gain implies that Muses can be used to optimise large pipelines that leverage multiple engines.}, language = {en} } @article{WambsganssHasingerGiacconietal.2000, author = {Wambsganß, Joachim and Hasinger, G{\"u}nther and Giacconi, R. and Gunn, J. E. and Lehmann, Ingo and Schmidt, M. and Schneider, D. P. and Stanke, Thomas and Tr{\"u}mper, J. and Woods, D. and Zamorani, G.}, title = {A Distant X-ray Selected, Gravitationally-Lensing Galaxy Cluster}, year = {2000}, language = {en} } @article{Petrova2006, author = {Petrova, Svetlana}, title = {A discourse-based approach to verb placement in early West-Germanic}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-19540}, year = {2006}, abstract = {The paper presents a novel approach to explaining word order variation in the early Germanic languages. Initial observations about verb placement as a device marking types of rhetorical relations made on data from Old High German (cf. Hinterh{\"o}lzl \& Petrova 2005) are now reconsidered on a larger scale and compared with evidence from other early Germanic languages. The paper claims that the identification of information-structural domains in a sentence is best achieved by taking into account the interaction between the pragmatic features of discourse referents and properties of discourse organization.}, language = {en} } @article{FussmannWeithoffYoshida2005, author = {Fussmann, Gregor F. and Weithoff, Guntram and Yoshida, Takehito}, title = {A direct, experimental test of resource vs. consumer dependence}, year = {2005}, abstract = {The uptake of resources from the environment is a vital process for all organisms. Many experimental studies have revealed that the rate at which this process occurs depends critically on the resource concentration, a relationship called "functional response." However, whether the concentration of the consumer normally affects the functional response has been the subject of a long-standing, predominantly theoretical, debate in ecology. Here we present an experimental test between the alternative hypotheses that food uptake depends either only on the resource concentration or on both the resource and the consumer concentrations. In short-term laboratory experiments, we measured the uptake of radioactively labeled, unicellular green algae (Monoraphidium minutum, resource) by the rotifer Brachionus calyciflorus (a consumer) for varying combinations of resource and consumer concentrations. We found that the food uptake by Brachionus depended on the algal concentration with the relationship best described by a Holling type 3 functional response. We detected significant consumer effects on the functional response only at an extraordinarily high Brachionus density (similar to 125 rotifers/mL), which by far exceeds concentrations normally encountered in the field. We conclude that con sumer-dependent food uptake by planktonic rotifers is a phenomenon that can occur under extreme conditions, but probably plays a minor role in natural environments}, language = {en} } @article{FussmannWeithoffYoshida2007, author = {Fussmann, Gregor F. and Weithoff, Guntram and Yoshida, Takehito}, title = {A direct, experimental test of resource versus consumer dependence : reply}, issn = {0012-9658}, doi = {10.1890/06-1692}, year = {2007}, language = {en} } @article{EttlingerSchenkMicheeletal.2012, author = {Ettlinger, Julia and Schenk, J{\"o}rg A. and Micheel, Burkhard and Ehrentreich-F{\"o}rster, Eva and Gajovic-Eichelmann, Nenad}, title = {A direct competitive homogeneous immunoassay for progesterone - the Redox Quenching Immunoassay}, series = {Electroanalysis : an international journal devoted to fundamental and practical aspects of electroanalysis}, volume = {24}, journal = {Electroanalysis : an international journal devoted to fundamental and practical aspects of electroanalysis}, number = {7}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1040-0397}, doi = {10.1002/elan.201200107}, pages = {1567 -- 1575}, year = {2012}, abstract = {A direct competitive amperometric immunoassay format for the detection of haptens and proteins was developed. The method is based on the quenching of electroactivity of ferrocenium, which is coupled to the antigen and used as the primary reporter, upon binding to a monoclonal anti-ferrocenium antibody, which is coupled to the detection antibody and used as a secondary reporter. A separation-free progesterone immunoassay with a lower detection limit of 1 ng?mL-1 (3.18 nmol?L-1) in 1?:?2 diluted blood serum was realised by combining two bifunctional conjugates, a ferrocenium-PEG-progesterone tracer and a bioconjugate of one anti-progesterone and one anti-ferrocenium antibody. The immune complex is formed within 30 s upon addition of progesterone, resulting in a total analysis time of 1.5 min.}, language = {en} } @article{SegeBradleyWeymaretal.2017, author = {Sege, Christopher T. and Bradley, Margaret M. and Weymar, Mathias and Lang, Peter J.}, title = {A direct comparison of appetitive and aversive anticipation}, series = {Behavioural brain research : an international journal}, volume = {326}, journal = {Behavioural brain research : an international journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0166-4328}, doi = {10.1016/j.bbr.2017.03.005}, pages = {96 -- 102}, year = {2017}, abstract = {fMRI studies of reward find increased neural activity in ventral striatum and medial prefrontal cortex (mPFC), whereas other regions, including the dorsolateral prefrontal cortex (d1PFC), anterior cingulate cortex (ACC), and anterior insula, are activated when anticipating aversive exposure. Although these data suggest differential activation during anticipation of pleasant or of unpleasant exposure, they also arise in the context of different paradigms (e.g., preparation for reward vs. threat of shock) and participants. To determine overlapping and unique regions active during emotional anticipation, we compared neural activity during anticipation of pleasant or unpleasant exposure in the same participants. Cues signalled the upcoming presentation of erotic/romantic, violent, or everyday pictures while BOLD activity during the 9-s anticipatory period was measured using fMRI. Ventral striatum and a ventral mPFC subregion were activated when anticipating pleasant, but not unpleasant or neutral, pictures, whereas activation in other regions was enhanced when anticipating appetitive or aversive scenes.}, language = {en} } @article{Schenck2022, author = {Schenck, Marcia C.}, title = {A different class of refugee: university scholarships and developmentalism in late 1960s Africa}, series = {Africa Today}, volume = {69}, journal = {Africa Today}, number = {1-2}, editor = {Schenck, Marcia C. and Njung, George N.}, publisher = {Indiana Univ. Press}, address = {Bloomington}, issn = {1527-1978}, doi = {10.2979/africatoday.69.1_2.07}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-569066}, pages = {134 -- 161}, year = {2022}, abstract = {Using documents assembled in connection with the 1967 Conference on the Legal, Economic and Social Aspects of African Refugee Problems, this article discusses African refugee higher-education discourses in the 1960s at the level of international organizations, volunteer agencies, and government representatives. Education and development history have recently been studied together, but this article focuses on the history of refugee higher education, which, it argues, needs to be understood within the development framework of human-capital theory, meant to support political pan African concerns for a decolonized continent and merged with humanitarian arguments to create a hybrid form of humanitarian developmentalism. The article zooms in on higher-education scholarships, above all for refugees from Southern Africa, as a means of support for human-capital development. It shows that refugee higher education was both a result and a driver of increased international exchanges, as evidenced at the 1967 conference.}, language = {en} } @article{BukovinszkyHelmsingGrauetal.2013, author = {Bukovinszky, Tibor and Helmsing, Nico R. and Grau, R. A. and Bakker, Elisabeth S. and Bezemer, T. Martijn and Vos, Matthijs and Uittenhout, H. and Verschoor, A. M.}, title = {A device to study the behavioral responses of zooplankton to food quality and quantity}, series = {Journal of insect behavior}, volume = {26}, journal = {Journal of insect behavior}, number = {4}, publisher = {Springer}, address = {New York}, issn = {0892-7553}, doi = {10.1007/s10905-012-9366-0}, pages = {453 -- 465}, year = {2013}, abstract = {In order to explore the behavioral mechanisms underlying aggregation of foragers on local resource patches, it is necessary to manipulate the location, quality and quantity of food patches. This requires careful control over the conditions in the foraging arena, which may be a challenging task in the case of aquatic resource-consumer systems, like that of freshwater zooplankton feeding on suspended algal cells. We present an experimental tool designed to aid behavioral ecologists in exploring the consequences of resource characteristics for zooplankton aggregation behavior and movement decisions under conditions where the boundaries and characteristics (quantity and quality) of food patches can be standardized. The aggregation behavior of Daphnia magna and D. galeata x hyalina was tested in relation to i) the presence or absence of food or ii) food quality, where algae of high or low nutrient (phosphorus) content were offered in distinct patches. Individuals of both Daphnia species chose tubes containing food patches and D. galeata x hyalina also showed a preference towards food patches of high nutrient content. We discuss how the described equipment complements other behavioral approaches providing a useful tool to understand animal foraging decisions in environments with heterogeneous resource distributions.}, language = {en} } @article{NazeOskinovaGosset2013, author = {Naze, Yael and Oskinova, Lida and Gosset, Eric}, title = {A detailed x-ray investigation of zeta puppis - II. the variability on short and long timescales}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {763}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/763/2/143}, pages = {21}, year = {2013}, abstract = {Stellar winds are a crucial component of massive stars, but their exact properties still remain uncertain. To shed some light on this subject, we have analyzed an exceptional set of X-ray observations of zeta Puppis, one of the closest and brightest massive stars. The sensitive light curves that were derived reveal two major results. On the one hand, a slow modulation of the X-ray flux (with a relative amplitude of up to 15\% over 16 hr in the 0.3-4.0 keV band) is detected. Its characteristic timescale cannot be determined with precision, but amounts from one to several days. It could be related to corotating interaction regions, known to exist in zeta Puppis from UV observations. Hour-long changes, linked to flares or to the pulsation activity, are not observed in the last decade covered by the XMM observations; the 17 hr tentative period, previously reported in a ROSAT analysis, is not confirmed either and is thus transient, at best. On the other hand, short-term changes are surprisingly small (<1\% relative amplitude for the total energy band). In fact, they are compatible solely with the presence of Poisson noise in the data. This surprisingly low level of short-term variability, in view of the embedded wind-shock origin, requires a very high fragmentation of the stellar wind, for both absorbing and emitting features (>10(5) parcels, comparing with a two-dimensional wind model). This is the first time that constraints have been placed on the number of clumps in an O-type star wind and from X-ray observations.}, language = {en} } @article{EhlertHolzweberLippitzetal.2016, author = {Ehlert, Christopher and Holzweber, Markus and Lippitz, Andreas and Unger, Wolfgang E. S. and Saalfrank, Peter}, title = {A detailed assignment of NEXAFS resonances of imidazolium based ionic liquids}, series = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, volume = {18}, journal = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/c5cp07434g}, pages = {8654 -- 8661}, year = {2016}, abstract = {In Near Edge X-Ray Absorption Fine Structure (NEXAFS) spectroscopy X-Ray photons are used to excite tightly bound core electrons to low-lying unoccupied orbitals of the system. This technique offers insight into the electronic structure of the system as well as useful structural information. In this work, we apply NEXAFS to two kinds of imidazolium based ionic liquids ([C(n)C(1)im](+)[NTf2](-) and [C(4)C(1)im](+)[I](-)). A combination of measurements and quantum chemical calculations of C K and N K NEXAFS resonances is presented. The simulations, based on the transition potential density functional theory method (TP-DFT), reproduce all characteristic features observed by the experiment. Furthermore, a detailed assignment of resonance features to excitation centers (carbon or nitrogen atoms) leads to a consistent interpretation of the spectra.}, language = {en} } @article{AndjelkovicSimevskiChenetal.2022, author = {Andjelkovic, Marko and Simevski, Aleksandar and Chen, Junchao and Schrape, Oliver and Stamenkovic, Zoran and Krstić, Miloš and Ilic, Stefan and Ristic, Goran and Jaksic, Aleksandar and Vasovic, Nikola and Duane, Russell and Palma, Alberto J. and Lallena, Antonio M. and Carvajal, Miguel A.}, title = {A design concept for radiation hardened RADFET readout system for space applications}, series = {Microprocessors and microsystems}, volume = {90}, journal = {Microprocessors and microsystems}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0141-9331}, doi = {10.1016/j.micpro.2022.104486}, pages = {18}, year = {2022}, abstract = {Instruments for measuring the absorbed dose and dose rate under radiation exposure, known as radiation dosimeters, are indispensable in space missions. They are composed of radiation sensors that generate current or voltage response when exposed to ionizing radiation, and processing electronics for computing the absorbed dose and dose rate. Among a wide range of existing radiation sensors, the Radiation Sensitive Field Effect Transistors (RADFETs) have unique advantages for absorbed dose measurement, and a proven record of successful exploitation in space missions. It has been shown that the RADFETs may be also used for the dose rate monitoring. In that regard, we propose a unique design concept that supports the simultaneous operation of a single RADFET as absorbed dose and dose rate monitor. This enables to reduce the cost of implementation, since the need for other types of radiation sensors can be minimized or eliminated. For processing the RADFET's response we propose a readout system composed of analog signal conditioner (ASC) and a self-adaptive multiprocessing system-on-chip (MPSoC). The soft error rate of MPSoC is monitored in real time with embedded sensors, allowing the autonomous switching between three operating modes (high-performance, de-stress and fault-tolerant), according to the application requirements and radiation conditions.}, language = {en} } @article{HlinakMuellerKrameretal.1999, author = {Hlinak, Andreas and M{\"u}ller, Thomas and Kramer, Matthias and M{\"u}hle, Ralf-Udo and Liebherr, Helga and Ziedler, Klaus}, title = {A descriptive analysis of the potenrial association between migration patterns of bean and white-fronted geese and the occurence of newcastle disease outbreaks in domestic birds}, issn = {0005-2086}, year = {1999}, abstract = {Sightings and migration patterns of 65 bean and 65 white-fronted geese are reported. These geese were tagged and serologically screened. 19 of the 53 birds sighted had serologic evidence of Newcastle Disease. The migration patterns of the wild geese provided further evidence that the main resting and wintering sites of migratory waterfowl are likely to be important for the inter- and intraspecies transmission of avian diseases.}, language = {en} } @article{MasanesMueller2011, author = {Masanes, Lluis and M{\"u}ller, Markus P.}, title = {A derivation of quantum theory from physical requirements}, series = {New journal of physics : the open-access journal for physics}, volume = {13}, journal = {New journal of physics : the open-access journal for physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1367-2630}, doi = {10.1088/1367-2630/13/6/063001}, pages = {29}, year = {2011}, abstract = {Quantum theory (QT) is usually formulated in terms of abstract mathematical postulates involving Hilbert spaces, state vectors and unitary operators. In this paper, we show that the full formalism of QT can instead be derived from five simple physical requirements, based on elementary assumptions regarding preparations, transformations and measurements. This is very similar to the usual formulation of special relativity, where two simple physical requirements-the principles of relativity and light speed invariance-are used to derive the mathematical structure of Minkowski space-time. Our derivation provides insights into the physical origin of the structure of quantum state spaces (including a group-theoretic explanation of the Bloch ball and its three dimensionality) and suggests several natural possibilities to construct consistent modifications of QT.}, language = {en} } @article{HentrichTaabacheBrezesinskietal.2017, author = {Hentrich, Doreen and Taabache, Soraya and Brezesinski, Gerald and Lange, Nele and Unger, Wolfgang and Kuebel, Christian and Bertin, Annabelle and Taubert, Andreas}, title = {A Dendritic Amphiphile for Efficient Control of Biomimetic Calcium Phosphate Mineralization}, series = {Macromolecular bioscience}, volume = {17}, journal = {Macromolecular bioscience}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1616-5187}, doi = {10.1002/mabi.201600524}, pages = {2541 -- 2548}, year = {2017}, abstract = {The phase behavior of a dendritic amphiphile containing a Newkome-type dendron as the hydrophilic moiety and a cholesterol unit as the hydrophobic segment is investigated at the air-liquid interface. The amphiphile forms stable monomolecular films at the airliquid interface on different subphases. Furthermore, the mineralization of calcium phosphate beneath the monolayer at different calcium and phosphate concentrations versus mineralization time shows that at low calcium and phosphate concentrations needles form, whereas flakes and spheres dominate at higher concentrations. Energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and electron diffraction confirm the formation of calcium phosphate. High-resolution transmission electron microscopy and electron diffraction confirm the predominant formation of octacalcium phosphate and hydroxyapatite. The data also indicate that the final products form via a complex multistep reaction, including an association step, where nano-needles aggregate into larger flake-like objects.}, language = {en} } @article{AlSaedyTarchanov2020, author = {Al-Saedy, Ammar Jaffar Muhesin and Tarchanov, Nikolaj Nikolaevič}, title = {A degree theory for Lagrangian boundary value problems}, series = {Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University; mathematics \& physics}, volume = {13}, journal = {Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University; mathematics \& physics}, number = {1}, publisher = {Sibirskij Federalʹnyj Universitet}, address = {Krasnojarsk}, issn = {1997-1397}, doi = {10.17516/1997-1397-2020-13-1-5-25}, pages = {5 -- 25}, year = {2020}, abstract = {We study those nonlinear partial differential equations which appear as Euler-Lagrange equations of variational problems. On defining weak boundary values of solutions to such equations we initiate the theory of Lagrangian boundary value problems in spaces of appropriate smoothness. We also analyse if the concept of mapping degree of current importance applies to Lagrangian problems.}, language = {en} } @article{JambrinaEnriquezSachseValeroGarces2016, author = {Jambrina-Enriquez, Margarita and Sachse, Dirk and Valero-Garces, Blas L.}, title = {A deglaciation and Holocene biomarker-based reconstruction of climate and environmental variability in NW Iberian Peninsula: the Sanabria Lake sequence}, series = {Journal of paleolimnolog}, volume = {56}, journal = {Journal of paleolimnolog}, publisher = {Springer}, address = {Dordrecht}, issn = {0921-2728}, doi = {10.1007/s10933-016-9890-6}, pages = {49 -- 66}, year = {2016}, abstract = {The molecular biomarker composition of two sediment cores from Sanabria Lake (NW Iberian Peninsula) and a survey of modern plants in the watershed provide a reconstruction of past vegetation and landscape dynamics since deglaciation. During a proglacial stage in Lake Sanabria (prior to 14.7 cal ka BP), very low biomarker concentration and carbon preference index (CPI) values similar to 1 suggest that the n-alkanes could have derived from eroded ancient sediment sources or older organic matter with high degree of maturity. During the Late glacial (14.7-11.7 cal ka BP) and the Holocene (last 11.7 cal ka BP) intervals with higher biomarker and triterpenoid concentrations (high \%nC(29) , nC(31) alkanes), higher CPI and average carbon length (ACL), and lower P-aq (proportion of aquatic plants) are indicative of major contribution of vascular land plants from a more forested watershed (e.g. Mid Holocene period 7.0-4.0 cal ka BP). Lower biomarker concentrations (high \%nC(27) alkanes), CPI and ACL values responded to short phases with decreased allochthonous contribution into the lake that correspond to centennial-scale periods of regional forest decline (e.g. 4-3 ka BP, Roman deforestation after 2.0 ka, and some phases of the LIA, seventeenth-nineteenth centuries). Human activities in the watershed were significant during early medieval times (1.3-1.0 cal ka BP) and since 1960 CE, in both cases associated with relatively higher productivity stages in the lake (lower biomarker and triterpenoid concentrations, high \%nC(23) and \%nC(31) respectively, lower ACL and CPI values and higher P-aq). The lipid composition of Sanabria Lake sediments indicates a major allochthonous (watershed-derived) contribution to the organic matter budget since deglaciation, and a dominant oligotrophic status during the lake history. The study constrains the climate and anthropogenic forcings and watershed versus lake sources in organic matter accumulation processes and helps to design conservation and management policies in mountain, oligotrophic lakes.}, language = {en} } @article{WangYangMeinel2016, author = {Wang, Cheng and Yang, Haojin and Meinel, Christoph}, title = {A deep semantic framework for multimodal representation learning}, series = {Multimedia tools and applications : an international journal}, volume = {75}, journal = {Multimedia tools and applications : an international journal}, publisher = {Springer}, address = {Dordrecht}, issn = {1380-7501}, doi = {10.1007/s11042-016-3380-8}, pages = {9255 -- 9276}, year = {2016}, abstract = {Multimodal representation learning has gained increasing importance in various real-world multimedia applications. Most previous approaches focused on exploring inter-modal correlation by learning a common or intermediate space in a conventional way, e.g. Canonical Correlation Analysis (CCA). These works neglected the exploration of fusing multiple modalities at higher semantic level. In this paper, inspired by the success of deep networks in multimedia computing, we propose a novel unified deep neural framework for multimodal representation learning. To capture the high-level semantic correlations across modalities, we adopted deep learning feature as image representation and topic feature as text representation respectively. In joint model learning, a 5-layer neural network is designed and enforced with a supervised pre-training in the first 3 layers for intra-modal regularization. The extensive experiments on benchmark Wikipedia and MIR Flickr 25K datasets show that our approach achieves state-of-the-art results compare to both shallow and deep models in multimodal and cross-modal retrieval.}, language = {en} } @article{PanzerBenderGronau2023, author = {Panzer, Marcel and Bender, Benedict and Gronau, Norbert}, title = {A deep reinforcement learning based hyper-heuristic for modular production control}, series = {International journal of production research}, journal = {International journal of production research}, publisher = {Taylor \& Francis}, address = {London}, issn = {0020-7543}, doi = {10.1080/00207543.2023.2233641}, pages = {1 -- 22}, year = {2023}, abstract = {In nowadays production, fluctuations in demand, shortening product life-cycles, and highly configurable products require an adaptive and robust control approach to maintain competitiveness. This approach must not only optimise desired production objectives but also cope with unforeseen machine failures, rush orders, and changes in short-term demand. Previous control approaches were often implemented using a single operations layer and a standalone deep learning approach, which may not adequately address the complex organisational demands of modern manufacturing systems. To address this challenge, we propose a hyper-heuristics control model within a semi-heterarchical production system, in which multiple manufacturing and distribution agents are spread across pre-defined modules. The agents employ a deep reinforcement learning algorithm to learn a policy for selecting low-level heuristics in a situation-specific manner, thereby leveraging system performance and adaptability. We tested our approach in simulation and transferred it to a hybrid production environment. By that, we were able to demonstrate its multi-objective optimisation capabilities compared to conventional approaches in terms of mean throughput time, tardiness, and processing of prioritised orders in a multi-layered production system. The modular design is promising in reducing the overall system complexity and facilitates a quick and seamless integration into other scenarios.}, language = {en} } @article{KriegerowskiPetersenVasyuraBathkeetal.2018, author = {Kriegerowski, Marius and Petersen, Gesa Maria and Vasyura-Bathke, Hannes and Ohrnberger, Matthias}, title = {A Deep Convolutional Neural Network for Localization of Clustered Earthquakes Based on Multistation Full Waveforms}, series = {Seismological research letters}, volume = {90}, journal = {Seismological research letters}, number = {2}, publisher = {Seismological Society of America}, address = {Albany}, issn = {0895-0695}, doi = {10.1785/0220180320}, pages = {510 -- 516}, year = {2018}, abstract = {Earthquake localization is both a necessity within the field of seismology, and a prerequisite for further analysis such as source studies and hazard assessment. Traditional localization methods often rely on manually picked phases. We present an alternative approach using deep learning that once trained can predict hypocenter locations efficiently. In seismology, neural networks have typically been trained with either single-station records or based on features that have been extracted previously from the waveforms. We use three-component full-waveform records of multiple stations directly. This means no information is lost during preprocessing and preparation of the data does not require expert knowledge. The first convolutional layer of our deep convolutional neural network (CNN) becomes sensitive to features that characterize the waveforms it is trained on. We show that this layer can therefore additionally be used as an event detector. As a test case, we trained our CNN using more than 2000 earthquake swarm events from West Bohemia, recorded by nine local three-component stations. The CNN successfully located 908 validation events with standard deviations of 56.4 m in east-west, 123.8 m in north-south, and 136.3 m in vertical direction compared to a double-difference relocated reference catalog. The detector is sensitive to events with magnitudes down to M-L = -0.8 with 3.5\% false positive detections.}, language = {en} } @article{NazeWangChuetal.2014, author = {Naze, Yael and Wang, Q. Daniel and Chu, You-Hua and Gruendl, Robert and Oskinova, Lida}, title = {A deep chandra observation of the giant HII region N11. I. x-ray sorces in the field}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, volume = {213}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Supplement series}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0067-0049}, doi = {10.1088/0067-0049/213/2/23}, pages = {20}, year = {2014}, abstract = {A very sensitive X-ray investigation of the giant HII region N11 in the Large Megallanic Cloud was performed using the Chandra X-ray Observatory. The 300 ks observation reveals X-ray sources with luminosities down to 10(32) erg s(-1), increasing the number of known point sources in the field by more than a factor of five. Among these detections are 13 massive stars (3 compact groups of massive stars, 9 O stars, and one early B star) with log(L-X/L-BOL) similar to -6.5 to -7, which may suggest that they are highly magnetic or colliding-wind systems. On the other hand, the stacked signal for regions corresponding to undetected O stars yields log(L-X/L-BOL) similar to -7.3, i.e., an emission level comparable to similar Galactic stars despite the lower metallicity. Other point sources coincide with 11 foreground stars, 6 late-B/A stars in N11, and many background objects. This observation also uncovers the extent and detailed spatial properties of the soft, diffuse emission regions, but the presence of some hotter plasma in their spectra suggests contamination by the unresolved stellar population.}, language = {en} } @article{ToetzkeMankeGaiselmannetal.2015, author = {T{\"o}tzke, Christian and Manke, Ingo and Gaiselmann, Gerd and Bohner, John and M{\"u}ller, Bernd R. and Kupsch, Andreas and Hentschel, Manfred P. and Schmidt, Volker and Banhart, Jens and Lehnert, Werner}, title = {A dedicated compression device for high resolution X-ray tomography of compressed gas diffusion layers}, series = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques}, volume = {86}, journal = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques}, number = {4}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0034-6748}, doi = {10.1063/1.4918291}, pages = {6}, year = {2015}, abstract = {We present an experimental approach to study the three-dimensional microstructure of gas diffusion layer (GDL) materials under realistic compression conditions. A dedicated compression device was designed that allows for synchrotron-tomographic investigation of circular samples under well-defined compression conditions. The tomographic data provide the experimental basis for stochastic modeling of nonwoven GDL materials. A plain compression tool is used to study the fiber courses in the material at different compression stages. Transport relevant geometrical parameters, such as porosity, pore size, and tortuosity distributions, are exemplarily evaluated for a GDL sample in the uncompressed state and for a compression of 30 vol.\%. To mimic the geometry of the flow-field, we employed a compression punch with an integrated channel-rib-profile. It turned out that the GDL material is homogeneously compressed under the ribs, however, much less compressed underneath the channel. GDL fibers extend far into the channel volume where they might interfere with the convective gas transport and the removal of liquid water from the cell. (C) 2015 AIP Publishing LLC.}, language = {en} } @article{GrumBenderAlfaetal.2018, author = {Grum, Marcus and Bender, Benedict and Alfa, A. S. and Gronau, Norbert}, title = {A decision maxim for efficient task realization within analytical network infrastructures}, series = {Decision support systems : DSS ; the international journal}, volume = {112}, journal = {Decision support systems : DSS ; the international journal}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-9236}, doi = {10.1016/j.dss.2018.06.005}, pages = {48 -- 59}, year = {2018}, abstract = {Faced with the increasing needs of companies, optimal dimensioning of IT hardware is becoming challenging for decision makers. In terms of analytical infrastructures, a highly evolutionary environment causes volatile, time dependent workloads in its components, and intelligent, flexible task distribution between local systems and cloud services is attractive. With the aim of developing a flexible and efficient design for analytical infrastructures, this paper proposes a flexible architecture model, which allocates tasks following a machine-specific decision heuristic. A simulation benchmarks this system with existing strategies and identifies the new decision maxim as superior in a first scenario-based simulation.}, language = {en} } @article{SchmidtBerger2013, author = {Schmidt, Bernd and Berger, Ren{\´e}}, title = {A deacetylation-diazotation-coupling sequence - palladium-catalyzed CC bond formation with acetanilides as formal leaving groups}, series = {Advanced synthesis \& catalysis}, volume = {355}, journal = {Advanced synthesis \& catalysis}, number = {2-3}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1615-4150}, doi = {10.1002/adsc.201200929}, pages = {463 -- 476}, year = {2013}, abstract = {Acetanilides can be deacetylated and diazotized in situ, and subsequently used in Pd-catalyzed coupling reactions without isolation of the diazonium intermediate. Heck reactions, Suzuki cross-coupling reactions, and a Pd-catalyzed [2+2+1]cycloaddition have been investigated as terminating CC bond-forming steps of this one-flask sequence. The sequence does not require the exchange of solvents or removal of by-products between the individual steps, but proceeds by addition of reagents and catalysts in due course.}, language = {en} } @article{ParkStolleXiongetal.2015, author = {Park, Jaeheung and Stolle, Claudia and Xiong, Chao and L{\"u}hr, Hermann and Pfaff, Robert F. and Buchert, Stephan and Martinis, Carlos R.}, title = {A dayside plasma depletion observed at midlatitudes during quiet geomagnetic conditions}, series = {Geophysical research letters}, volume = {42}, journal = {Geophysical research letters}, number = {4}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1002/2014GL062655}, pages = {967 -- 974}, year = {2015}, abstract = {In this study we investigate a dayside, midlatitude plasma depletion (DMLPD) encountered on 22 May 2014 by the Swarm and GRACE satellites, as well as ground-based instruments. The DMLPD was observed near Puerto Rico by Swarm near 10 LT under quiet geomagnetic conditions at altitudes of 475-520 km and magnetic latitudes of similar to 25 degrees-30 degrees. The DMLPD was also revealed in total electron content observations by the Saint Croix station and by the GRACE satellites (430 km) near 16 LT and near the same geographic location. The unique Swarm constellation enables the horizontal tilt of the DMLPD to be measured (35 degrees clockwise from the geomagnetic east-west direction). Ground-based airglow images at Arecibo showed no evidence for plasma density depletions during the night prior to this dayside event. The C/NOFS equatorial satellite showed evidence for very modest plasma density depletions that had rotated into the morningside from nightside. However, the equatorial depletions do not appear related to the DMLPD, for which the magnetic apex height is about 2500 km. The origins of the DMLPD are unknown, but may be related to gravity waves.}, language = {en} } @article{BrillPassuniPinedaEspichanCuyaetal.2020, author = {Brill, Fabio Alexander and Passuni Pineda, Silvia and Espichan Cuya, Bruno and Kreibich, Heidi}, title = {A data-mining approach towards damage modelling for El Nino events in Peru}, series = {Geomatics, natural hazards and risk}, volume = {11}, journal = {Geomatics, natural hazards and risk}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1947-5705}, doi = {10.1080/19475705.2020.1818636}, pages = {1966 -- 1990}, year = {2020}, abstract = {Compound natural hazards likeEl Ninoevents cause high damage to society, which to manage requires reliable risk assessments. Damage modelling is a prerequisite for quantitative risk estimations, yet many procedures still rely on expert knowledge, and empirical studies investigating damage from compound natural hazards hardly exist. A nationwide building survey in Peru after theEl Ninoevent 2017 - which caused intense rainfall, ponding water, flash floods and landslides - enables us to apply data-mining methods for statistical groundwork, using explanatory features generated from remote sensing products and open data. We separate regions of different dominant characteristics through unsupervised clustering, and investigate feature importance rankings for classifying damage via supervised machine learning. Besides the expected effect of precipitation, the classification algorithms select the topographic wetness index as most important feature, especially in low elevation areas. The slope length and steepness factor ranks high for mountains and canyons. Partial dependence plots further hint at amplified vulnerability in rural areas. An example of an empirical damage probability map, developed with a random forest model, is provided to demonstrate the technical feasibility.}, language = {en} } @article{Stephan2014, author = {Stephan, Christoph A.}, title = {A dark sector extension of the almost-commutative standard model}, series = {International journal of modern physics : A, Particles and fields, gravitation, cosmology, nuclear physics}, volume = {29}, journal = {International journal of modern physics : A, Particles and fields, gravitation, cosmology, nuclear physics}, number = {1}, publisher = {World Scientific}, address = {Singapore}, issn = {0217-751X}, doi = {10.1142/S0217751X14500055}, pages = {30}, year = {2014}, abstract = {We consider an extension of the Standard Model within the framework of Noncommutative Geometry. The model is based on an older model [C. A. Stephan, Phys. Rev. D 79, 065013 (2009)] which extends the Standard Model by new fermions, a new U(1)-gauge group and, crucially, a new scalar field which couples to the Higgs field. This new scalar field allows to lower the mass of the Higgs mass from similar to 170 GeV, as predicted by the Spectral Action for the Standard Model, to a value of 120-130 GeV. The shortcoming of the previous model lay in its inability to meet all the constraints on the gauge couplings implied by the Spectral Action. These shortcomings are cured in the present model which also features a "dark sector" containing fermions and scalar particles.}, language = {en} } @article{ChenWarsinkeGajovicetal.2000, author = {Chen, Ziping and Warsinke, Axel and Gajovic, Nenad and Große, St. and Hu, J. and Kleber, H.-P. and Scheller, Frieder W.}, title = {A D-carnitine dehydrogenase electrode for the assessment of enantiomeric purity of L-carnitine preparations}, year = {2000}, language = {en} } @article{LandauLoksteinSchelleretal.2009, author = {Landau, Alejandra Mabel and Lokstein, Heiko and Scheller, Henrik Vibe and Lainez, Veronica and Maldonado, Sara and Prina, Alberto Ra{\´u}l}, title = {A cytoplasmically inherited barley mutant is defective in photosystem I assembly due to a temperature-sensitive defect in ycf3 splicing}, issn = {0032-0889}, doi = {10.1104/pp.109.147843}, year = {2009}, abstract = {A cytoplasmically inherited chlorophyll-deficient mutant of barley (Hordeum vulgare) termed cytoplasmic line 3 (CL3), displaying a viridis (homogeneously light-green colored) phenotype, has been previously shown to be affected by elevated temperatures. In this article, biochemical, biophysical, and molecular approaches were used to study the CL3 mutant under different temperature and light conditions. The results lead to the conclusion that an impaired assembly of photosystem I (PSI) under higher temperatures and certain light conditions is the primary cause of the CL3 phenotype. Compromised splicing of ycf3 transcripts, particularly at elevated temperature, resulting from a mutation in a noncoding region (intron 1) in the mutant ycf3 gene results in a defective synthesis of Ycf3, which is a chaperone involved in PSI assembly. The defective PSI assembly causes severe photoinhibition and degradation of PSII.}, language = {en} } @article{SamuelHornDoeringetal.2011, author = {Samuel, Prinson P. and Horn, Sebastian and D{\"o}ring, Alexander and Havelius, Kajsa G. V. and Reschke, Stefan and Leimk{\"u}hler, Silke and Haumann, Michael and Schulzke, Carola}, title = {A Crystallographic and Mo K-Edge XAS Study of Molybdenum Oxo Bis-,Mono-, and Non-Dithiolene Complexes - First-Sphere Coordination Geometry and Noninnocence of Ligands}, series = {European journal of inorganic chemistry : a journal of ChemPubSoc Europe}, journal = {European journal of inorganic chemistry : a journal of ChemPubSoc Europe}, number = {28}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1434-1948}, doi = {10.1002/ejic.201100331}, pages = {4387 -- 4399}, year = {2011}, abstract = {Ten square-based pyramidal molybdenum complexes with different sulfur donor ligands, that is, a variety of dithiolenes and sulfides, were prepared, which mimic coordination motifs of the molybdenum cofactors of molybdenum-dependent oxidoreductases. The model compounds were investigated by Mo K-edge X-ray absorption spectroscopy (XAS) and (with one exception) their molecular structures were analyzed by X-ray diffraction to derive detailed information on bond lengths and geometries of the first coordination shell of molybdenum. Only small variations in Mo=O and Mo-S bond lengths and their respective coordination angles were observed for all complexes including those containing Mo(CO)(2) or Mo(mu-S)(2)Mo motifs. XAS analysis (edge energy) revealed higher relative oxidation levels in the molybdenum ion in compounds with innocent sulfur-based ligands relative to those in dithiolene complexes, which are known to exhibit noninnocence, that is, donation of substantial electron density from ligand to metal. In addition, longer average Mo-S and Mo=O bonds and consequently lower.(Mo=O) stretching frequencies in the IR spectra were observed for complexes with dithiolene-derived ligands. The results emphasize that the noninnocent character of the dithiolene ligand influences the electronic structure of the model compounds, but does not significantly affect their metal coordination geometry, which is largely determined by the Mo(IV) or (V) ion itself. The latter conclusion also holds for the molybdenum site geometries in the oxidized Mo-VI cofactor of DMSO reductase and the reduced Mo-IV cofactor of arsenite oxidase. The innocent behavior of the dithiolene molybdopterin ligands observed in the enzymes is likely to be related to cofactor-protein interactions.}, language = {en} } @article{LotzeCampenVerburgPoppetal.2017, author = {Lotze-Campen, Hermann and Verburg, Peter H. and Popp, Alexander and Lindner, Marcus and Verkerk, Pieter J. and Moiseyev, Alexander and Schrammeijer, Elizabeth and Helming, John and Tabeau, Andrzej and Schulp, Catharina J. E. and van der Zanden, Emma H. and Lavalle, Carlo and Batista e Silva, Filipe and Walz, Ariane and Bodirsky, Benjamin Leon}, title = {A cross-scale impact assessment of European nature protection policies under contrasting future socio-economic pathways}, series = {Regional environmental change}, volume = {18}, journal = {Regional environmental change}, number = {3}, publisher = {Springer}, address = {Heidelberg}, issn = {1436-3798}, doi = {10.1007/s10113-017-1167-8}, pages = {751 -- 762}, year = {2017}, abstract = {Protection of natural or semi-natural ecosystems is an important part of societal strategies for maintaining biodiversity, ecosystem services, and achieving overall sustainable development. The assessment of multiple emerging land use trade-offs is complicated by the fact that land use changes occur and have consequences at local, regional, and even global scale. Outcomes also depend on the underlying socio-economic trends. We apply a coupled, multi-scale modelling system to assess an increase in nature protection areas as a key policy option in the European Union (EU). The main goal of the analysis is to understand the interactions between policy-induced land use changes across different scales and sectors under two contrasting future socio-economic pathways. We demonstrate how complementary insights into land system change can be gained by coupling land use models for agriculture, forestry, and urban areas for Europe, in connection with other world regions. The simulated policy case of nature protection shows how the allocation of a certain share of total available land to newly protected areas, with specific management restrictions imposed, may have a range of impacts on different land-based sectors until the year 2040. Agricultural land in Europe is slightly reduced, which is partly compensated for by higher management intensity. As a consequence of higher costs, total calorie supply per capita is reduced within the EU. While wood harvest is projected to decrease, carbon sequestration rates increase in European forests. At the same time, imports of industrial roundwood from other world regions are expected to increase. Some of the aggregate effects of nature protection have very different implications at the local to regional scale in different parts of Europe. Due to nature protection measures, agricultural production is shifted from more productive land in Europe to on average less productive land in other parts of the world. This increases, at the global level, the allocation of land resources for agriculture, leading to a decrease in tropical forest areas, reduced carbon stocks, and higher greenhouse gas emissions outside of Europe. The integrated modelling framework provides a method to assess the land use effects of a single policy option while accounting for the trade-offs between locations, and between regional, European, and global scales.}, language = {en} } @article{LuetkecosmannFaupelPorstmannetal.2019, author = {Luetkecosmann, Steffi and Faupel, Thomas and Porstmann, Silvia and Porstmann, Tomas and Micheel, Burkhard and Hanack, Katja}, title = {A cross-reactive monoclonal antibody as universal detection antibody in autoantibody diagnostic assays}, series = {Clinica chimica acta}, volume = {499}, journal = {Clinica chimica acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0009-8981}, doi = {10.1016/j.cca.2019.09.003}, pages = {87 -- 92}, year = {2019}, abstract = {Diagnostics of Autoimmune Diseases involve screening of patient samples for containing autoantibodies against various antigens. To ensure quality of diagnostic assays a calibrator is needed in each assay system. Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of polyclonal sera from other species. Nevertheless, the detection of human autoantibodies as well as the calibration reagent containing antibodies from other species in one assay constitutes a challenge in terms of assay calibration. We therefore developed a cross-reactive monoclonal antibody which binds human as well as rabbit sera with similar affinities in the nanomolar range. We tested our monoclonal antibody S38CD11B12 successfully in the commercial Serazym (R) Anti-Cardiolipin-beta 2-GPI IgG/IgM assay and could thereby prove the eligibility of S38CD11B12 as detection antibody in autoimmune diagnostic assays using rabbit derived sera as reference material.}, language = {en} } @article{SchmidtStaudeKellingetal.2011, author = {Schmidt, Bernd and Staude, Lucia and Kelling, Alexandra and Schilde, Uwe}, title = {A Cross-Metathesis-Conjugate addition route to enantiopure gamma-Butyrolactams and gamma-Lactones from a C-2-Symmetric Precursor}, series = {European journal of organic chemistry}, journal = {European journal of organic chemistry}, number = {9}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {1434-193X}, doi = {10.1002/ejoc.201001528}, pages = {1721 -- 1727}, year = {2011}, abstract = {A protected derivative of (3R, 4R)-hexa-1,5-diene-3,4-diol, a conveniently accessible C-2-symmetric building block, undergoes single or double cross metathesis with methyl acryl-ate. The cross metathesis products are amenable to stereoselective conjugate addition reactions and can be converted into either gamma-butyrolactones or gamma-lactams.}, language = {en} } @article{WilliamsEscudero2014, author = {Williams, Daniel and Escudero, Paola}, title = {A cross-dialectal acoustic comparison of vowels in Northern and Southern British English}, series = {The journal of the Acoustical Society of America}, volume = {136}, journal = {The journal of the Acoustical Society of America}, number = {5}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0001-4966}, doi = {10.1121/1.4896471}, pages = {2751 -- 2761}, year = {2014}, abstract = {This study compares the duration and first two formants (F1 and F2) of 11 nominal monophthongs and five nominal diphthongs in Standard Southern British English (SSBE) and a Northern English dialect. F1 and F2 trajectories were fitted with parametric curves using the discrete cosine transform (DCT) and the zeroth DCT coefficient represented formant trajectory means and the first DCT coefficient represented the magnitude and direction of formant trajectory change to characterize vowel inherent spectral change (VISC). Cross-dialectal comparisons involving these measures revealed significant differences for the phonologically back monophthongs /D, , , u:/ and also /3z:/ and the diphthongs /eI, e, aI, I/. Most cross-dialectal differences are in zeroth DCT coefficients, suggesting formant trajectory means tend to characterize such differences, while first DCT coefficient differences were more numerous for diphthongs. With respect to VISC, the most striking differences are that /u:/is considerably more diphthongized in the Northern dialect and that the F2 trajectory of /e/proceeds in opposite directions in the two dialects. Cross-dialectal differences were found to be largely unaffected by the consonantal context in which the vowels were produced. The implications of the results are discussed in relation to VISC, consonantal context effects and speech perception. (c) 2014 Acoustical Society of America.}, language = {en} } @article{Jakupec2017, author = {Jakupec, Viktor}, title = {A Critique of the development aid discourse}, series = {Development aid—populism and the end of the neoliberal agenda}, journal = {Development aid—populism and the end of the neoliberal agenda}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-72748-6}, issn = {2211-4548}, doi = {10.1007/978-3-319-72748-6_3}, pages = {37 -- 52}, year = {2017}, abstract = {Despite the fact that development aid has broadened from economic growth theory to include human and social capital, there is a lack of a general agreement as to its benefits. This critical review and analyses of the development aid academic and institutional discourse identifies some major shortcomings. The dominance of economics at the expense of politics, and the imposition of development aid neoliberal conditionalities act as barriers to socio-economic development in aid recipient countries. An inference is offered to recast development aid through reconciliation within critical frameworks of different sides of the political spectrum.}, language = {en} } @article{PietschHansen1996, author = {Pietsch, Ullrich and Hansen, N. K.}, title = {A critical review of the valence charge density in GaAs}, year = {1996}, language = {en} } @article{ScheweLevermannCheng2012, author = {Schewe, Jacob and Levermann, Anders and Cheng, Hai}, title = {A critical humidity threshold for monsoon transitions}, series = {Climate of the past : an interactive open access journal of the European Geosciences Union}, volume = {8}, journal = {Climate of the past : an interactive open access journal of the European Geosciences Union}, number = {2}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1814-9324}, doi = {10.5194/cp-8-535-2012}, pages = {535 -- 544}, year = {2012}, abstract = {Monsoon systems around the world are governed by the so-called moisture-advection feedback. Here we show that, in a minimal conceptual model, this feedback implies a critical threshold with respect to the atmospheric specific humidity q(o) over the ocean adjacent to the monsoon region. If q(o) falls short of this critical value q(o)(c), monsoon rainfall over land cannot be sustained. Such a case could occur if evaporation from the ocean was reduced, e.g. due to low sea surface temperatures. Within the restrictions of the conceptual model, we estimate q(o)(c) from present-day reanalysis data for four major monsoon systems, and demonstrate how this concept can help understand abrupt variations in monsoon strength on orbital timescales as found in proxy records.}, language = {en} } @article{DeRosaSchrijverBarnesetal.2009, author = {DeRosa, Marc L. and Schrijver, Carolus J. and Barnes, Graham and Leka, K. D. and Lites, Bruce W. and Aschwanden, Markus J. and Amari, Tahar and Canou, Aur{\´e}lien and McTiernan, James M. and R{\´e}gnier, St{\´e}phane and Thalmann, Julia K. and Valori, Gherardo and Wheatland, Michael S. and Wiegelmann, Thomas and Cheung, Mark C. M. and Conlon, Paul A. and Fuhrmann, Marcel and Inhester, Bernd and Tadesse, Tilaye}, title = {A critical assessment of nonlinear force-free field modeling of the solar corona for active region 10953}, issn = {0004-637X}, doi = {10.1088/0004-637x/696/2/1780}, year = {2009}, abstract = {Nonlinear force-free field (NLFFF) models are thought to be viable tools for investigating the structure, dynamics, and evolution of the coronae of solar active regions. In a series of NLFFF modeling studies, we have found that NLFFF models are successful in application to analytic test cases, and relatively successful when applied to numerically constructed Sun-like test cases, but they are less successful in application to real solar data. Different NLFFF models have been found to have markedly different field line configurations and to provide widely varying estimates of the magnetic free energy in the coronal volume, when applied to solar data. NLFFF models require consistent, force-free vector magnetic boundary data. However, vector magnetogram observations sampling the photosphere, which is dynamic and contains significant Lorentz and buoyancy forces, do not satisfy this requirement, thus creating several major problems for force-free coronal modeling efforts. In this paper, we discuss NLFFF modeling of NOAA Active Region 10953 using Hinode/SOT-SP, Hinode/XRT, STEREO/SECCHI-EUVI, and SOHO/MDI observations, and in the process illustrate three such issues we judge to be critical to the success of NLFFF modeling: (1) vector magnetic field data covering larger areas are needed so that more electric currents associated with the full active regions of interest are measured, (2) the modeling algorithms need a way to accommodate the various uncertainties in the boundary data, and (3) a more realistic physical model is needed to approximate the photosphere-to-corona interface in order to better transform the forced photospheric magnetograms into adequate approximations of nearly force-free fields at the base of the corona. We make recommendations for future modeling efforts to overcome these as yet unsolved problems.}, language = {en} } @article{ZechAttingerBellinetal.2019, author = {Zech, Alraune and Attinger, Sabine and Bellin, Alberto and Cvetkovic, Vladimir and Dietrich, Peter and Fiori, Aldo and Teutsch, Georg and Dagan, Gedeon}, title = {A Critical Analysis of Transverse Dispersivity Field Data}, series = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, volume = {57}, journal = {Groundwater : journal of the Association of Ground-Water Scientists and Engineers, a division of the National Ground Water Association}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0017-467X}, doi = {10.1111/gwat.12838}, pages = {632 -- 639}, year = {2019}, abstract = {Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio-degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error-prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field-scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation-specific, span three orders of magnitude and do not show any clear scale-dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity.}, language = {en} } @article{EberliBernoulliVecseietal.2019, author = {Eberli, Gregor P. and Bernoulli, Daniel and Vecsei, Adam and Sekti, Rizky and Grasmueck, Mark and L{\"u}dmann, Thomas and Anselmetti, Flavio S. and Mutti, Maria and Della Porta, Giovanna}, title = {A Cretaceous carbonate delta drift in the Montagna della Maiella, Italy}, series = {Sedimentology : the journal of the International Association of Sedimentologists}, volume = {66}, journal = {Sedimentology : the journal of the International Association of Sedimentologists}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {0037-0746}, doi = {10.1111/sed.12590}, pages = {1266 -- 1301}, year = {2019}, abstract = {The Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is compared to newly discovered contourite drifts in the Maldives. Like the drift deposits in the Maldives, the Orfento Formation fills a channel and builds a Miocene delta-shaped and mounded sedimentary body in the basin that is similar in size to the approximately 350 km(2) large coarse-grained bioclastic Miocene delta drifts in the Maldives. The composition of the bioclastic wedge of the Orfento Formation is also exclusively bioclastic debris sourced from the shallow-water areas and reworked clasts of the Orfento Formation itself. In the near mud-free succession, age-diagnostic fossils are sparse. The depositional textures vary from wackestone to float-rudstone and breccia/conglomerates, but rocks with grainstone and rudstone textures are the most common facies. In the channel, lensoid convex-upward breccias, cross-cutting channelized beds and thick grainstone lobes with abundant scours indicate alternating erosion and deposition from a high-energy current. In the basin, the mounded sedimentary body contains lobes with a divergent progradational geometry. The lobes are built by decametre thick composite megabeds consisting of sigmoidal clinoforms that typically have a channelized topset, a grainy foreset and a fine-grained bottomset with abundant irregular angular clasts. Up to 30 m thick channels filled with intraformational breccias and coarse grainstones pinch out downslope between the megabeds. In the distal portion of the wedge, stacked grainstone beds with foresets and reworked intraclasts document continuous sediment reworking and migration. The bioclastic wedge of the Orfento Formation has been variously interpreted as a succession of sea-level controlled slope deposits, a shoaling shoreface complex, or a carbonate tidal delta. Current-controlled delta drifts in the Maldives, however, offer a new interpretation because of their similarity in architecture and composition. These similarities include: (i) a feeder channel opening into the basin; (ii) an excavation moat at the exit of the channel; (iii) an overall mounded geometry with an apex that is in shallower water depth than the source channel; (iv) progradation of stacked lobes; (v) channels that pinch out in a basinward direction; and (vi) smaller channelized intervals that are arranged in a radial pattern. As a result, the Upper Cretaceous (Campanian-Maastrichtian) bioclastic wedge of the Orfento Formation in the Montagna della Maiella, Italy, is here interpreted as a carbonate delta drift.}, language = {en} } @article{KratkySchroederAbe2020, author = {Kratky, Nicole and Schr{\"o}der-Ab{\´e}, Michela}, title = {A court file analysis of child protection cases}, series = {Child \& family social work}, volume = {25}, journal = {Child \& family social work}, number = {S1}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1356-7500}, doi = {10.1111/cfs.12744}, pages = {169 -- 177}, year = {2020}, abstract = {Children's participation in legal proceedings affecting them personally has been gaining importance. So far, a primary research concern has been how children experience their participation in court proceedings. However, little is known about the child's voice itself: Are children able to clearly express their wishes, and if so, what do they say in child protection cases? In this study, we extracted information about children's statements from court file data of 220 child protection cases in Germany. We found 182 children were asked about their wishes. The majority of the statements found came either from reports of the guardians ad litem or from judicial records of the child hearings. Using content analysis, three main aspects of the statements were extracted: wishes concerning main place of residence, wishes about whom to have or not contact with, and children granting decision-making authority to someone else. Children's main focus was on their parents, but others (e.g., relatives and foster care providers) were also mentioned. Intercoder agreement was substantial. Making sure that child hearings are as informative as possible is in the child's best interest. Therefore, the categories developed herein might help professionals to ask questions more precisely relevant to the child.}, language = {en} } @article{Buerger2018, author = {B{\"u}rger, Gerd}, title = {A counterexample to decomposing climate shifts and trends by weather types}, series = {International Journal of Climatology}, volume = {38}, journal = {International Journal of Climatology}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {0899-8418}, doi = {10.1002/joc.5519}, pages = {3732 -- 3735}, year = {2018}, abstract = {The literature contains a sizable number of publications where weather types are used to decompose climate shifts or trends into contributions of frequency and mean of those types. They are all based on the product rule, that is, a transformation of a product of sums into a sum of products, the latter providing the decomposition. While there is nothing to argue about the transformation itself, its interpretation as a climate shift or trend decomposition is bound to fail. While the case of a climate shift may be viewed as an incomplete description of a more complex behaviour, trend decomposition indeed produces bogus trends, as demonstrated by a synthetic counterexample with well-defined trends in type frequency and mean. Consequently, decompositions based on that transformation, be it for climate shifts or trends, must not be used.}, language = {en} } @article{BuyinzaDereseNdakalaetal.2021, author = {Buyinza, Daniel and Derese, Solomon and Ndakala, Albert and Heydenreich, Matthias and Yenesew, Abiy and Koch, Andreas and Oriko, Richard}, title = {A coumestan and a coumaronochromone from Millettia lasiantha}, series = {Biochemical systematics and ecology}, volume = {97}, journal = {Biochemical systematics and ecology}, publisher = {Elsevier}, address = {Oxford}, issn = {0305-1978}, doi = {10.1016/j.bse.2021.104277}, pages = {5}, year = {2021}, abstract = {The manuscript describes the phytochemical investigation of the roots, leaves and stem bark of Millettia lasiantha resulting in the isolation of twelve compounds including two new isomeric isoflavones lascoumestan and las-coumaronochromone. The structures of the new compounds were determined using different spectroscopic techniques.}, language = {en} } @article{Leung2016, author = {Leung, Ray C. H.}, title = {A corpus-based analysis of textbooks used in the orientation course for immigrants in Germany: Ideological and pedagogic implications}, series = {Journal of Language and Cultural Education}, volume = {4}, journal = {Journal of Language and Cultural Education}, publisher = {De Gruyter}, address = {Berlin}, issn = {1339-4045}, doi = {10.1515/jolace-2016-0030}, pages = {154 -- 177}, year = {2016}, language = {en} } @article{ShenarOskinovaHamannetal.2015, author = {Shenar, Tomer and Oskinova, Lida and Hamann, Wolf-Rainer and Corcoran, Michael F. and Moffat, Anthony F. J. and Pablo, Herbert and Richardson, Noel D. and Waldron, Wayne L. and Huenemoerder, David P. and Maiz Apellaniz, Jesus and Nichols, Joy S. and Todt, Helge Tobias and Naze, Yael and Hoffman, Jennifer L. and Pollock, Andy M. T. and Negueruela, Ignacio}, title = {A coordinated X-Ray and optical campaign of the nearest massive eclipsing binary, delta ORIONIS Aa. IV. A multiwavelength, non-lte spectroscopic analysis}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {809}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/809/2/135}, pages = {20}, year = {2015}, abstract = {Eclipsing systems of massive stars allow one to explore the properties of their components in great detail. We perform a multi-wavelength, non-LTE analysis of the three components of the massive multiple system delta Ori A, focusing on the fundamental stellar properties, stellar winds, and X-ray characteristics of the system. The primary's distance-independent parameters turn out to be characteristic for its spectral type (O9.5 II), but usage of the Hipparcos parallax yields surprisingly low values for the mass, radius, and luminosity. Consistent values follow only if delta Ori lies at about twice the Hipparcos distance, in the vicinity of the sigma-Orionis cluster. The primary and tertiary dominate the spectrum and leave the secondary only marginally detectable. We estimate the V-band magnitude difference between primary and secondary to be Delta V approximate to 2.(m)8. The inferred parameters suggest that the secondary is an early B-type dwarf (approximate to B1 V), while the tertiary is an early B-type subgiant (approximate to B0 IV). We find evidence for rapid turbulent velocities (similar to 200 km s(-1)) and wind inhomogeneities, partially optically thick, in the primary's wind. The bulk of the X-ray emission likely emerges from the primary's stellar wind (logL(X)/L-Bol approximate to -6.85), initiating close to the stellar surface at R-0 similar to 1.1 R-*. Accounting for clumping, the mass-loss rate of the primary is found to be log (M) over dot approximate to -6.4 (M-circle dot yr(-1))., which agrees with hydrodynamic predictions, and provides a consistent picture along the X-ray, UV, optical, and radio spectral domains.}, language = {en} } @article{PabloRichardsonMoffatetal.2015, author = {Pablo, Herbert and Richardson, Noel D. and Moffat, Anthony F. J. and Corcoran, Michael and Shenar, Tomer and Benvenuto, Omar and Fuller, Jim and Naze, Yael and Hoffman, Jennifer L. and Miroshnichenko, Anatoly and Apellaniz, Jesus Maiz and Evans, Nancy and Eversberg, Thomas and Gayley, Ken and Gull, Ted and Hamaguchi, Kenji and Hamann, Wolf-Rainer and Henrichs, Huib and Hole, Tabetha and Ignace, Richard and Iping, Rosina and Lauer, Jennifer and Leutenegger, Maurice and Lomax, Jamie and Nichols, Joy and Oskinova, Lida and Owocki, Stan and Pollock, Andy and Russell, Christopher M. P. and Waldron, Wayne and Buil, Christian and Garrel, Thierry and Graham, Keith and Heathcote, Bernard and Lemoult, Thierry and Li, Dong and Mauclaire, Benjamin and Potter, Mike and Ribeiro, Jose and Matthews, Jaymie and Cameron, Chris and Guenther, David and Kuschnig, Rainer and Rowe, Jason and Rucinski, Slavek and Sasselov, Dimitar and Weiss, Werner}, title = {A coordinated X-Ray and optical campaign of the nearest massive eclipsing binary, delta ORIONIS Aa. III. Analysis of optical photometric (most) and spectroscopic (ground based) variations}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {809}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/809/2/134}, pages = {11}, year = {2015}, abstract = {We report on both high-precision photometry from the Microvariability and Oscillations of Stars (MOST) space telescope and ground-based spectroscopy of the triple system delta Ori A, consisting of a binary O9.5II+early-B (Aa1 and Aa2) with P = 5.7 days, and a more distant tertiary (O9 IV P > 400 years). This data was collected in concert with X-ray spectroscopy from the Chandra X-ray Observatory. Thanks to continuous coverage for three weeks, the MOST light curve reveals clear eclipses between Aa1 and Aa2 for the first time in non-phased data. From the spectroscopy, we have a well-constrained radial velocity (RV) curve of Aa1. While we are unable to recover RV variations of the secondary star, we are able to constrain several fundamental parameters of this system and determine an approximate mass of the primary using apsidal motion. We also detected second order modulations at 12 separate frequencies with spacings indicative of tidally influenced oscillations. These spacings have never been seen in a massive binary, making this system one of only a handful of such binaries that show evidence for tidally induced pulsations.}, language = {en} } @article{NicholsHuenemoerderCorcoranetal.2015, author = {Nichols, Joy and Huenemoerder, David P. and Corcoran, Michael F. and Waldron, Wayne and Naze, Yael and Pollock, Andy M. T. and Moffat, Anthony F. J. and Lauer, Jennifer and Shenar, Tomer and Russell, Christopher M. P. and Richardson, Noel D. and Pablo, Herbert and Evans, Nancy Remage and Hamaguchi, Kenji and Gull, Theodore and Hamann, Wolf-Rainer and Oskinova, Lida and Ignace, Rosina and Hoffman, Jennifer L. and Hole, Karen Tabetha and Lomax, Jamie R.}, title = {A COORDINATED X-RAY AND OPTICAL CAMPAIGN OF THE NEAREST MASSIVE ECLIPSING BINARY, delta ORIONIS Aa. II. X-RAY VARIABILITY}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {809}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/809/2/133}, pages = {21}, year = {2015}, abstract = {We present time-resolved and phase-resolved variability studies of an extensive X-ray high-resolution spectral data set of the delta Ori Aa binary system. The four observations, obtained with Chandra ACIS HETGS, have a total exposure time of approximate to 479 ks and provide nearly complete binary phase coverage. Variability of the total X-ray flux in the range of 5-25 is is confirmed, with a maximum amplitude of about +/- 15\% within a single approximate to 125 ks observation. Periods of 4.76 and 2.04 days are found in the total X-ray flux, as well as an apparent overall increase in the flux level throughout the nine-day observational campaign. Using 40 ks contiguous spectra derived from the original observations, we investigate the variability of emission line parameters and ratios. Several emission lines are shown to be variable, including S XV, Si XIII, and Ne IX. For the first time, variations of the X-ray emission line widths as a function of the binary phase are found in a binary system, with the smallest widths at phi = 0.0 when the secondary delta Ori Aa2 is at the inferior conjunction. Using 3D hydrodynamic modeling of the interacting winds, we relate the emission line width variability to the presence of a wind cavity created by a wind-wind collision, which is effectively void of embedded wind shocks and is carved out of the X-ray-producing primary wind, thus producing phase-locked X-ray variability.}, language = {en} } @article{CorcoranNicholsPabloetal.2015, author = {Corcoran, Michael F. and Nichols, Joy S. and Pablo, Herbert and Shenar, Tomer and Pollock, Andy M. T. and Waldron, Wayne L. and Moffat, Anthony F. J. and Richardson, Noel D. and Russell, Christopher M. P. and Hamaguchi, Kenji and Huenemoerder, David P. and Oskinova, Lida and Hamann, Wolf-Rainer and Naze, Yael and Ignace, Richard and Evans, Nancy Remage and Lomax, Jamie R. and Hoffman, Jennifer L. and Gayley, Kenneth and Owocki, Stanley P. and Leutenegger, Maurice and Gull, Theodore R. and Hole, Karen Tabetha and Lauer, Jennifer and Iping, Rosina C.}, title = {A coordinated X-Ray and optical campaign of the nearest massive eclipsing binary, delta ORIONIS Aa. I. Overview of thr X-Ray spectrum}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {809}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.1088/0004-637X/809/2/132}, pages = {15}, year = {2015}, abstract = {We present an overview of four deep phase-constrained Chandra HETGS X-ray observations of delta Ori A. Delta Ori A is actually a triple system that includes the nearest massive eclipsing spectroscopic binary, delta Ori Aa, the only such object that can be observed with little phase-smearing with the Chandra gratings. Since the fainter star, delta Ori Aa2, has a much lower X-ray luminosity than the brighter primary (delta Ori Aa1), delta Ori Aa provides a unique system with which to test the spatial distribution of the X-ray emitting gas around delta Ori Aa1 via occultation by the photosphere of, and wind cavity around, the X-ray dark secondary. Here we discuss the X-ray spectrum and X-ray line profiles for the combined observation, having an exposure time of nearly 500 ks and covering nearly the entire binary orbit. The companion papers discuss the X-ray variability seen in the Chandra spectra, present new space-based photometry and ground-based radial velocities obtained simultaneously with the X-ray data to better constrain the system parameters, and model the effects of X-rays on the optical and UV spectra. We find that the X-ray emission is dominated by embedded wind shock emission from star Aa1, with little contribution from the tertiary star Ab or the shocked gas produced by the collision of the wind of Aa1 against the surface of Aa2. We find a similar temperature distribution to previous X-ray spectrum analyses. We also show that the line half-widths are about 0.3-0.5 times the terminal velocity of the wind of star Aa1. We find a strong anti-correlation between line widths and the line excitation energy, which suggests that longer-wavelength, lower-temperature lines form farther out in the wind. Our analysis also indicates that the ratio of the intensities of the strong and weak lines of Fe XVII and Ne X are inconsistent with model predictions, which may be an effect of resonance scattering.}, language = {en} } @article{CvetkovićConradLie2021, author = {Cvetković, Nada and Conrad, Tim and Lie, Han Cheng}, title = {A convergent discretization method for transition path theory for diffusion processes}, series = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, volume = {19}, journal = {Multiscale modeling \& simulation : a SIAM interdisciplinary journal}, number = {1}, publisher = {Society for Industrial and Applied Mathematics}, address = {Philadelphia}, issn = {1540-3459}, doi = {10.1137/20M1329354}, pages = {242 -- 266}, year = {2021}, abstract = {Transition path theory (TPT) for diffusion processes is a framework for analyzing the transitions of multiscale ergodic diffusion processes between disjoint metastable subsets of state space. Most methods for applying TPT involve the construction of a Markov state model on a discretization of state space that approximates the underlying diffusion process. However, the assumption of Markovianity is difficult to verify in practice, and there are to date no known error bounds or convergence results for these methods. We propose a Monte Carlo method for approximating the forward committor, probability current, and streamlines from TPT for diffusion processes. Our method uses only sample trajectory data and partitions of state space based on Voronoi tessellations. It does not require the construction of a Markovian approximating process. We rigorously prove error bounds for the approximate TPT objects and use these bounds to show convergence to their exact counterparts in the limit of arbitrarily fine discretization. We illustrate some features of our method by application to a process that solves the Smoluchowski equation on a triple-well potential.}, language = {en} } @article{Buerger2022, author = {B{\"u}rger, Gerd}, title = {A conundrum of trends}, series = {Journal of hydrology}, volume = {609}, journal = {Journal of hydrology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-1694}, doi = {10.1016/j.jhydrol.2022.127745}, pages = {3}, year = {2022}, abstract = {This comment is meant to reiterate two warnings: One applies to the uncritical use of ready-made (openly available) program packages, and one to the estimation of trends in serially correlated time series. Both warnings apply to the recent publication of Lischeid et al. about lake-level trends in Germany.}, language = {en} } @article{WinterSchneebergerDungetal.2019, author = {Winter, Benjamin and Schneeberger, Klaus and Dung, N. V. and Huttenlau, M. and Achleitner, S. and St{\"o}tter, J. and Merz, Bruno and Vorogushyn, Sergiy}, title = {A continuous modelling approach for design flood estimation on sub-daily time scale}, series = {Hydrological sciences journal = Journal des sciences hydrologiques}, volume = {64}, journal = {Hydrological sciences journal = Journal des sciences hydrologiques}, number = {5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0262-6667}, doi = {10.1080/02626667.2019.1593419}, pages = {539 -- 554}, year = {2019}, abstract = {Design flood estimation is an essential part of flood risk assessment. Commonly applied are flood frequency analyses and design storm approaches, while the derived flood frequency using continuous simulation has been getting more attention recently. In this study, a continuous hydrological modelling approach on an hourly time scale, driven by a multi-site weather generator in combination with a -nearest neighbour resampling procedure, based on the method of fragments, is applied. The derived 100-year flood estimates in 16 catchments in Vorarlberg (Austria) are compared to (a) the flood frequency analysis based on observed discharges, and (b) a design storm approach. Besides the peak flows, the corresponding runoff volumes are analysed. The spatial dependence structure of the synthetically generated flood peaks is validated against observations. It can be demonstrated that the continuous modelling approach can achieve plausible results and shows a large variability in runoff volume across the flood events.}, language = {en} } @article{MaierWiljesHartungetal.2022, author = {Maier, Corinna Sabrina and Wiljes, Jana de and Hartung, Niklas and Kloft, Charlotte and Huisinga, Wilhelm}, title = {A continued learning approach for model-informed precision dosing}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {11}, journal = {CPT: pharmacometrics \& systems pharmacology}, number = {2}, publisher = {London}, address = {Nature Publ. Group}, issn = {2163-8306}, doi = {10.1002/psp4.12745}, pages = {185 -- 198}, year = {2022}, abstract = {Model-informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug-disease-patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized dosing in ongoing treatment. Structural models and prior parameter distributions used in MIPD approaches typically build on prior clinical trials that involve only a limited number of patients selected according to some exclusion/inclusion criteria. Compared to the prior clinical trial population, the patient population in clinical practice can be expected to also include altered behavior and/or increased interindividual variability, the extent of which, however, is typically unknown. Here, we address the question of how to adapt and refine models on the level of the model parameters to better reflect this real-world diversity. We propose an approach for continued learning across patients during MIPD using a sequential hierarchical Bayesian framework. The approach builds on two stages to separate the update of the individual patient parameters from updating the population parameters. Consequently, it enables continued learning across hospitals or study centers, because only summary patient data (on the level of model parameters) need to be shared, but no individual TDM data. We illustrate this continued learning approach with neutrophil-guided dosing of paclitaxel. The present study constitutes an important step toward building confidence in MIPD and eventually establishing MIPD increasingly in everyday therapeutic use.}, language = {en} } @article{BesnardSchaub1993, author = {Besnard, Philippe and Schaub, Torsten H.}, title = {A context-based framework for default logics}, isbn = {0-262-51071-5}, year = {1993}, language = {en} } @article{ReyesPerezMorissetPenaetal.2015, author = {Reyes-P{\´e}rez, J. and Morisset, C. and Pena, M. and Mesa-Delgado, A.}, title = {A consistent spectral model of WR 136 and its associated bubble NGC 6888}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-88274}, pages = {321 -- 324}, year = {2015}, abstract = {We analyse whether a stellar atmosphere model computed with the code CMFGEN provides an optimal description of the stellar observations of WR 136 and simultaneously reproduces the nebular observations of NGC 6888, such as the ionization degree, which is modelled with the pyCloudy code. All the observational material available (far and near UV and optical spectra) were used to constrain such models. We found that the stellar temperature T∗, at τ = 20, can be in a range between 70 000 and 110 000 K, but when using the nebula as an additional restriction, we found that the stellar models with T∗ ∼ 70 000 K represent the best solution for both, the star and the nebula.}, language = {en} } @article{DelgrandeSchaub2000, author = {Delgrande, James Patrick and Schaub, Torsten H.}, title = {A consistency-based model for belief change: preliminary report}, isbn = {0-262-51112-6}, year = {2000}, language = {en} } @article{DelgrandeSchaub2000, author = {Delgrande, James Patrick and Schaub, Torsten H.}, title = {A consistency-based model for belief change: preliminary report}, year = {2000}, language = {en} } @article{DelgrandeSchaub2007, author = {Delgrande, James Patrick and Schaub, Torsten H.}, title = {A consistency-based framework for merging knowledge bases}, issn = {1570-8683}, year = {2007}, language = {en} } @article{WolffGastEversetal.2021, author = {Wolff, Martin and Gast, Klaus and Evers, Andreas and Kurz, Michael and Pfeiffer-Marek, Stefania and Sch{\"u}ler, Anja and Seckler, Robert and Thalhammer, Anja}, title = {A Conserved Hydrophobic Moiety and Helix-Helix Interactions Drive the Self-Assembly of the Incretin Analog Exendin-4}, series = {Biomolecules}, volume = {11}, journal = {Biomolecules}, number = {9}, publisher = {MDPI}, address = {Basel}, issn = {2218-273X}, doi = {10.3390/biom11091305}, pages = {20}, year = {2021}, abstract = {Exendin-4 is a pharmaceutical peptide used in the control of insulin secretion. Structural information on exendin-4 and related peptides especially on the level of quaternary structure is scarce. We present the first published association equilibria of exendin-4 directly measured by static and dynamic light scattering. We show that exendin-4 oligomerization is pH dependent and that these oligomers are of low compactness. We relate our experimental results to a structural hypothesis to describe molecular details of exendin-4 oligomers. Discussion of the validity of this hypothesis is based on NMR, circular dichroism and fluorescence spectroscopy, and light scattering data on exendin-4 and a set of exendin-4 derived peptides. The essential forces driving oligomerization of exendin-4 are helix-helix interactions and interactions of a conserved hydrophobic moiety. Our structural hypothesis suggests that key interactions of exendin-4 monomers in the experimentally supported trimer take place between a defined helical segment and a hydrophobic triangle constituted by the Phe22 residues of the three monomeric subunits. Our data rationalize that Val19 might function as an anchor in the N-terminus of the interacting helix-region and that Trp25 is partially shielded in the oligomer by C-terminal amino acids of the same monomer. Our structural hypothesis suggests that the Trp25 residues do not interact with each other, but with C-terminal Pro residues of their own monomers.}, language = {en} } @article{ChapmanLantOhashietal.2019, author = {Chapman, Eric M. and Lant, Benjamin and Ohashi, Yota and Yu, Bin and Schertzberg, Michael and Go, Christopher and Dogra, Deepika and Koskimaki, Janne and Girard, Romuald and Li, Yan and Fraser, Andrew G. and Awad, Issam A. and Abdelilah-Seyfried, Salim and Gingras, Anne-Claude and Derry, William Brent}, title = {A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis}, series = {Nature Communications}, volume = {10}, journal = {Nature Communications}, publisher = {Nature Publ. Group}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-019-09829-z}, pages = {15}, year = {2019}, abstract = {Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.}, language = {en} } @article{BrueningSchaub2000, author = {Br{\"u}ning, Stefan and Schaub, Torsten H.}, title = {A connection calculus for handling incomplete information}, year = {2000}, language = {en} } @article{Dulgheru2016, author = {Dulgheru, Elena}, title = {A Conjunction of Mysteries}, series = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 1}, journal = {Andrej Tarkovskij: Klassiker - Классик - Classic - Classico : Beitr{\"a}ge zum internationalen Tarkovskij-Symposium an der Universit{\"a}t Potsdam ; Band 1}, publisher = {Universit{\"a}t Potsdam}, address = {Potsdam}, isbn = {978-3-86956-351-0}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95594}, pages = {201 -- 214}, year = {2016}, language = {en} } @article{KramerKleinpeter2013, author = {Kramer, Markus and Kleinpeter, Erich}, title = {A conformational study of N-acetyl glucosamine derivatives utilizing residual dipolar couplings}, issn = {1090-7807}, year = {2013}, language = {en} } @article{KramerKleinpeter2011, author = {Kramer, Markus and Kleinpeter, Erich}, title = {A conformational study of N-acetyl glucosamine derivatives utilizing residual dipolar couplings}, series = {Journal of magnetic resonance}, volume = {212}, journal = {Journal of magnetic resonance}, number = {1}, publisher = {Elsevier}, address = {San Diego}, issn = {1090-7807}, doi = {10.1016/j.jmr.2011.06.029}, pages = {174 -- 185}, year = {2011}, abstract = {The conformational analyses of six non-rigid N-acetyl glucosamine (NAG) derivatives employing residual dipolar couplings (RDCs) and NOEs together with molecular dynamics (MD) simulations are presented. Due to internal dynamics we had to consider different conformer ratios existing in solution. The good quality of the correlation between theoretically and experimentally obtained RDCs show the correctness of the calculated conformers even if the ratios derived from the MD simulations do not exactly meet the experimental data. If possible, the results were compared to former published data and commented.}, language = {en} } @article{KleinpeterBalciYaparetal.2012, author = {Kleinpeter, Erich and Balci, Kubilay and Yapar, G. and Akkaya, S. and Akyuz, S. and Koch, Andreas}, title = {A conformational analysis and vibrational spectroscopic investigation on 1,2-bis(o-carboxyphenoxy) ethane molecule}, year = {2012}, abstract = {The minima on the potential energy surface of 1,2-bis(o-carboxyphenoxy) ethane (CPE) molecule in its electronic ground state were searched by a molecular dynamics simulation performed with MM2 force field. For each of the found minimum-energy conformers, the corresponding equilibrium geometry, charge distribution, HOMO-LUMO energy gap, force field, vibrational normal modes and associated IR and Raman spectral data were determined by means of the density functional theory (DFT) based electronic structure calculations carried out by using B3LYP method and various Pople- style basis sets. The obtained theoretical data confirmed the significant effects of the intra- and inter-molecular hydrogen bonding interactions on the conformational structure, force field, and group vibrations of the molecule. The same data have also revealed that two of the determined stable conformers, both of which exhibit pseudo-crown structure, are considerably more favorable in energy to the others and accordingly provide the major c ntribution to the experimental spectra of CPE. In the light of the improved vibrational spectral data obtained within the "SQM FF" methodology and "Dual Scale Factors" approach for the monomer and dimer forms of these two conformers, a reliable assignment of the fundamental bands observed in the experimental room-temperature IR and Raman spectra of the molecule was given, and the sensitivities of its group vibratb20s to conformation, substitution and dimerization were discussed.}, language = {en} } @article{BalciYaparAkkayaetal.2012, author = {Balci, Kubilay and Yapar, G. and Akkaya, Y. and Akyuz, S. and Koch, Andreas and Kleinpeter, Erich}, title = {A conformational analysis and vibrational spectroscopic investigation on 1,2-bis(o-carboxyphenoxy) ethane molecule}, series = {Vibrational spectroscopy : an international journal devoted to applications of infrared and raman spectroscopy}, volume = {58}, journal = {Vibrational spectroscopy : an international journal devoted to applications of infrared and raman spectroscopy}, number = {1-2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-2031}, doi = {10.1016/j.vibspec.2011.11.011}, pages = {27 -- 43}, year = {2012}, abstract = {The minima on the potential energy surface of 1,2-bis(o-carboxyphenoxy)ethane (CPE) molecule in its electronic ground state were searched by a molecular dynamics simulation performed with MM2 force field. For each of the found minimum-energy conformers, the corresponding equilibrium geometry, charge distribution, HOMO-LUMO energy gap, force field, vibrational normal modes and associated IR and Raman spectral data were determined by means of the density functional theory (DFT) based electronic structure calculations carried out by using B3LYP method and various Pople-style basis sets. The obtained theoretical data confirmed the significant effects of the intra- and inter-molecular hydrogen bonding interactions on the conformational structure, force field, and group vibrations of the molecule. The same data have also revealed that two of the determined stable conformers, both of which exhibit pseudo-crown structure, are considerably more favorable in energy to the others and accordingly provide the major contribution to the experimental spectra of CPE. In the light of the improved vibrational spectral data obtained within the "SQM FF" methodology and "Dual Scale Factors" approach for the monomer and dimer forms of these two conformers, a reliable assignment of the fundamental bands observed in the experimental room-temperature IR and Raman spectra of the molecule was given, and the sensitivities of its group vibrations to conformation, substitution and dimerization were discussed.}, language = {en} } @article{WilkeAppelVinczeetal.2010, author = {Wilke, Max and Appel, Karen and Vincze, Laszlo and Schmidt, Christian and Borchert, Manuela and Pascarelli, Sakura}, title = {A confocal set-up for micro-XRF and XAFS experiments using diamond-anvil cells}, issn = {0909-0495}, doi = {10.1107/S0909049510023654}, year = {2010}, abstract = {A confocal set-up is presented that improves micro-XRF and XAFS experiment with high-pressure e diamond-anvil cells (DACs) In this experiment a probing volume is defined by the focus of the incoming synchrotron radiation beam and that of a polycapillary X-ray half-lens with a very long working distance, which is placed in front of the fluorescence detector This set-up enhances the quality of the fluorescence and XAFS spectra, and thus the sensitivity for detecting elements at low concentrations. It efficiently suppresses signal from outside the sample chamber, which stems from elastic and inelastic scattering of the incoming beam by the diamond anvils as well as from excitation of fluorescence from the body of the DAC}, language = {en} } @article{MuehlenbruchKuxhausPencinaetal.2015, author = {M{\"u}hlenbruch, Kristin and Kuxhaus, Olga and Pencina, Michael J. and Boeing, Heiner and Liero, Hannelore and Schulze, Matthias Bernd}, title = {A confidence ellipse for the Net Reclassification Improvement}, series = {European journal of epidemiology}, volume = {30}, journal = {European journal of epidemiology}, number = {4}, publisher = {Springer}, address = {Dordrecht}, issn = {0393-2990}, doi = {10.1007/s10654-015-0001-1}, pages = {299 -- 304}, year = {2015}, abstract = {The Net Reclassification Improvement (NRI) has become a popular metric for evaluating improvement in disease prediction models through the past years. The concept is relatively straightforward but usage and interpretation has been different across studies. While no thresholds exist for evaluating the degree of improvement, many studies have relied solely on the significance of the NRI estimate. However, recent studies recommend that statistical testing with the NRI should be avoided. We propose using confidence ellipses around the estimated values of event and non-event NRIs which might provide the best measure of variability around the point estimates. Our developments are illustrated using practical examples from EPIC-Potsdam study.}, language = {en} } @article{KniepertLangevanderKaapetal.2014, author = {Kniepert, Juliane and Lange, Ilja and van der Kaap, Niels J. and Koster, L. Jan Anton and Neher, Dieter}, title = {A conclusive view on charge generation, recombination, and extraction in As-prepared and annealed P3HT:PCBM blends: combined experimental and simulation work}, series = {dvanced energy materials}, volume = {4}, journal = {dvanced energy materials}, number = {7}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.201301401}, pages = {11}, year = {2014}, abstract = {Time-delayed collection field (TDCF) and bias-amplified charge extraction (BACE) are applied to as-prepared and annealed poly(3-hexylthiophene):[6,6]-phenyl C-71 butyric acid methyl ester (P3HT:PCBM) blends coated from chloroform. Despite large differences in fill factor, short-circuit current, and power conversion efficiency, both blends exhibit a negligible dependence of photogeneration on the electric field and strictly bimolecular recombination (BMR) with a weak dependence of the BMR coefficient on charge density. Drift-diffusion simulations are performed using the measured coefficients and mobilities, taking into account bimolecular recombination and the possible effects of surface recombination. The excellent agreement between the simulation and the experimental data for an intensity range covering two orders of magnitude indicates that a field-independent generation rate and a density-independent recombination coefficient describe the current-voltage characteristics of the annealed P3HT: PCBM devices, while the performance of the as-prepared blend is shown to be limited by space charge effects due to a low hole mobility. Finally, even though the bimolecular recombination coefficient is small, surface recombination is found to be a negligible loss mechanism in these solar cells.}, language = {en} } @article{DelgrandeSchaub2003, author = {Delgrande, James Patrick and Schaub, Torsten H.}, title = {A concictency-based paradigm for belief change}, issn = {0004-3702}, year = {2003}, language = {en} } @article{DragičevićUllrichTsuietal.2020, author = {Dragičević, Nikolina and Ullrich, Andr{\´e} and Tsui, Eric and Gronau, Norbert}, title = {A conceptual model of knowledge dynamics in the industry 4.0 smart grid scenario}, series = {Knowledge management research \& practice : KMRP}, volume = {18}, journal = {Knowledge management research \& practice : KMRP}, number = {2}, publisher = {Taylor \& Francis}, address = {London [u.a.]}, issn = {1477-8238}, doi = {10.1080/14778238.2019.1633893}, pages = {199 -- 213}, year = {2020}, abstract = {Technological advancements are giving rise to the fourth industrial revolution - Industry 4.0 -characterized by the mass employment of smart objects in highly reconfigurable and thoroughly connected industrialproduct-service systems. The purpose of this paper is to propose a theory-based knowledgedynamics model in the smart grid scenario that would provide a holistic view on the knowledge-based interactions among smart objects, humans, and other actors as an underlyingmechanism of value co-creation in Industry 4.0. A multi-loop and three-layer - physical, virtual, and interface - model of knowledge dynamics is developedby building on the concept of ba - an enabling space for interactions and theemergence of knowledge. The model depicts how big data analytics are just one component inunlocking the value of big data, whereas the tacit engagement of humans-in-the-loop - theirsense-making and decision-making - is needed for insights to be evoked fromanalytics reports and customer needs to be met.}, language = {en} } @article{SchurrDeanMiltonetal.2004, author = {Schurr, Frank Martin and Dean, W. R. J. and Milton, Sue J. and Jeltsch, Florian}, title = {A conceptual model linking demography of the shrub species Grewia flava to the dynamics of Kalahari savannas}, year = {2004}, abstract = {Environmental heterogeneity is a major determinant of plant population dynamics. In semi-arid Kalahari savannas, heterogeneity is created by savanna structure, i.e. by the spatial arrangement and temporal dynamics of woody plant and open grassland microsites. We formulate a conceptual model describing the effects of savanna dynamics on the population dynamics of the animal-dispersed shrub Grewia flava. From empirical results we derive model rules describing effects of savanna structure on several processes in Grewia's life cycle. By formulating the model, we summarise existing information on Grewia demography and identify gaps in this knowledge. Despite a number of such gaps, the model can be used to make certain quantitative predictions. As an example, we apply the model to investigate the role of seed dispersal in Grewia encroachment on rangelands. Model results show that cattle promote encroachment by depositing substantial numbers of seeds in open areas, where Grewia is otherwise dispersal-limited. Finally, we draw some general conclusions about Grewia's life history and population dynamics. Under natural conditions, concentrated seed deposition under woody plants appears to be a key process causing the observed association between Grewia and other woody plants. Furthermore, low rates of recruitment and high adult survival result in slow-motion dynamics of Grewia populations. As a consequence, Grewia populations interact with savanna dynamics on long temporal and short to intermediate spatial scales.}, language = {en} } @article{WiggeringSteinhardt2015, author = {Wiggering, Hubert and Steinhardt, Uta}, title = {A conceptual model for site-specific agricultural land-use}, series = {Ecological modelling : international journal on ecological modelling and engineering and systems ecolog}, volume = {295}, journal = {Ecological modelling : international journal on ecological modelling and engineering and systems ecolog}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0304-3800}, doi = {10.1016/j.ecolmodel.2014.08.011}, pages = {42 -- 46}, year = {2015}, abstract = {Land-use concepts provide decision support for the most efficient usage options according to sustainable development and multifunctionality requirements. However, developments in landscape-related, agricultural production schemes are primarily driven by economic benefits. Therefore, most agricultural land-use concepts tackle particular problems or interests and lack a systemic perspective. As a result, we discuss a conceptual model for future site-specific agricultural land-use with an inbuilt requirement for adequate experimental sites to enable monitoring systems for a new generation of ecosystem models and for new approaches to address science-stakeholder interactions.}, language = {en} } @article{Muschalla2018, author = {Muschalla, Beate}, title = {A concept of psychological work capacity demands}, series = {Work : a journal of prevention, assessment \& rehabilitation}, volume = {59}, journal = {Work : a journal of prevention, assessment \& rehabilitation}, number = {3}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1051-9815}, doi = {10.3233/WOR-182691}, pages = {375 -- 386}, year = {2018}, abstract = {BACKGROUND: Work capacity demands are a concept to describe which psychological capacities are required in a job. Assessing psychological work capacity demands is of specific importance when mental health problems at work endanger work ability. Exploring psychological work capacity demands is the basis for mental hazard analysis or rehabilitative action, e.g. in terms of work adjustment. OBJECTIVE: This is the first study investigating psychological work capacity demands in rehabilitation patients with and without mental disorders. METHODS: A structured interview on psychological work capacity demands (Mini-ICF-Work; Muschalla, 2015; Linden et al., 2015) was done with 166 rehabilitation patients of working age. All interviews were done by a state-licensed socio-medically trained psychotherapist. Inter-rater-reliability was assessed by determining agreement in independent co-rating in 65 interviews. For discriminant validity purposes, participants filled in the Short Questionnaire for Work Analysis (KFZA, Prumper et al., 1994). RESULTS: In different professional fields, different psychological work capacity demands were of importance. The Mini-ICF-Work capacity dimensions reflect different aspects than the KFZA. Patients with mental disorders were longer on sick leave and had worse work ability prognosis than patients without mental disorders, although both groups reported similar work capacity demands. CONCLUSIONS: Psychological work demands - which are highly relevant for work ability prognosis and work adjustment processes - can be explored and differentiated in terms of psychological capacity demands.}, language = {en} } @article{StaufferMengeshaSeifertetal.2022, author = {Stauffer, Maxime and Mengesha, Isaak and Seifert, Konrad and Krawczuk, Igor and Fischer, Jens and Serugendo, Giovanna Di Marzo}, title = {A computational turn in policy process studies}, series = {Complexity}, volume = {2022}, journal = {Complexity}, publisher = {Wiley-Hindawi}, address = {London}, issn = {1076-2787}, doi = {10.1155/2022/8210732}, pages = {17}, year = {2022}, abstract = {The past three decades of policy process studies have seen the emergence of a clear intellectual lineage with regard to complexity. Implicitly or explicitly, scholars have employed complexity theory to examine the intricate dynamics of collective action in political contexts. However, the methodological counterparts to complexity theory, such as computational methods, are rarely used and, even if they are, they are often detached from established policy process theory. Building on a critical review of the application of complexity theory to policy process studies, we present and implement a baseline model of policy processes using the logic of coevolving networks. Our model suggests that an actor's influence depends on their environment and on exogenous events facilitating dialogue and consensus-building. Our results validate previous opinion dynamics models and generate novel patterns. Our discussion provides ground for further research and outlines the path for the field to achieve a computational turn.}, language = {en} }