@phdthesis{Grosso2021, author = {Grosso, Stefano}, title = {Anerkennung und Macht}, doi = {10.25932/publishup-50846}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-508461}, school = {Universit{\"a}t Potsdam}, pages = {152}, year = {2021}, abstract = {In der vorliegenden Untersuchung habe ich das Ziel verfolgt, einen sachlich-eigenst{\"a}ndigen Beitrag f{\"u}r eine Debatte gegen Honneths kritische Gesellschaftstheorie zu leisten. In dieser Debatte wird Honneth dahingehend kritisiert, dass es ihm mit seiner kritischen Gesellschaftstheorie entgegen seiner eigenen systematischen Zielsetzung nicht gelingt, in modernen liberaldemokratischen Gesellschaften s{\"a}mtliche Ph{\"a}nomene von sozialer Herrschaft kritisch zu hinterfragen. Denn soziale Anerkennung, die Honneth als Schl{\"u}sselbegriff f{\"u}r diese kritische Hinterfragung behandelt, bei der soziale Herrschaft in Verbindung mit sozialer Missachtung (als mangelnde soziale Anerkennung) steht, kann laut der Kritik faktisch selbst ein Medium f{\"u}r die Stiftung von sozialer Unterwerfung sein. Dies geschieht in Prozessen von Identit{\"a}tsentwicklung, in denen soziale Anerkennung f{\"u}r Individuen als Anerkannte bestimmte Identit{\"a}tsm{\"o}glichkeiten einr{\"a}umt und auf diese Weise gleichzeitig andere Identit{\"a}tsm{\"o}glichkeiten ausschließt, womit sie auf diese Identit{\"a}t einschr{\"a}nkend und insofern herrschend wirkt. Es handelt sich um eine Form von sozialer Herrschaft, die durch soziale Anerkennung gestiftet wird. Honneth zieht dem Vorwurf zufolge nicht in Erw{\"a}gung, dass soziale Anerkennung bei Individuen als Anerkannte einen solchen negativen Effekt erzielen kann. Hieraus ergeben sich die Fragen, ob soziale Anerkennung in Prozessen von Identit{\"a}tsentwicklung jeweils mit sozialer Herrschaft einhergeht und wie dieser Typus von sozialer Herrschaft kritisiert werden kann. Diese Fragen hat Honneth zuletzt in einem pers{\"o}nlichen Gespr{\"a}ch mit Allen und Cooke (als zwei Teilnehmerinnen der Debatte gegen Honneth) beantwortet. An dieser Stelle vertritt er mit beiden Gespr{\"a}chsteilnehmerinnen die Auffassung, dass die Operation der Einschr{\"a}nkung von Identit{\"a}tsm{\"o}glichkeiten an sich keine Operation darstellt, welche, wie sonst in der Debatte gegen seine kritische Gesellschaftstheorie behauptet wird, auf soziale Herrschaft zur{\"u}ckf{\"u}hrt. Diese Auffassung beruht auf der Idee, wonach soziale Anerkennung sich in jenem praktischen Kontext nur unter der Bedingung als herrschaftsstiftend erweist, dass sie immanente Prinzipien verletzt, die substanziell kritische Maßst{\"a}be definieren. Mein Beitrag zu dieser Debatte gegen Honneth besteht auf der einen Seite in der Erkl{\"a}rung, dass sowohl jene Auffassung als auch jene Idee argumentativ mangelhaft sind, und auf der anderen Seite in der Ausf{\"u}hrung des Vorhabens, diesen argumentativen Mangel selbst zu beheben. Gegen jene Auffassung behaupte ich, dass die drei Autoren in ihrem Gespr{\"a}ch nicht erl{\"a}utern, inwiefern soziale Anerkennung nicht herrschend wirkt, wenn sie die Identit{\"a}tsm{\"o}glichkeiten von Individuen als Anerkannte einschr{\"a}nkt, denn mit dieser Einschr{\"a}nkung wird vielmehr faktisch {\"u}ber diese Individuen geherrscht - die Debatte gegen Honneth, so zur Unterst{\"u}tzung dieser Ansicht, baut haupts{\"a}chlich auf ebendiesem Faktum auf. Gegen jene Idee habe ich f{\"u}nf problematische Fragen gestellt und beantwortet, die Bezug eigentlich nicht allein auf diese Idee selbst, sondern {\"u}berdies auf weitere, naheliegende Ideen nehmen, welche die drei Autoren angesprochen haben.}, language = {de} } @misc{BiterovaEsmaeeliMoghaddamTabalvandaniAlanenetal.2018, author = {Biterova, Ekaterina and Esmaeeli Moghaddam Tabalvandani, Mariam and Alanen, Heli I. and Saaranen, Mirva and Ruddock, Lloyd W.}, title = {Structures of Angptl3 and Angptl4}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1048}, issn = {1866-8372}, doi = {10.25932/publishup-46794}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-467943}, pages = {14}, year = {2018}, abstract = {Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34\% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery disease.}, language = {en} } @misc{GiraudierVenturaBortWeymar2020, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {649}, issn = {1866-8364}, doi = {10.25932/publishup-47412}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-474125}, pages = {15}, year = {2020}, abstract = {Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular VNS (tVNS) to replicate and extend the previous work. Using a single-blind, randomized, between-subject design, 60 healthy volunteers received active or sham stimulation during a lexical decision task, in which emotional and neutral stimuli were classified as words or non-words. In a subsequent recognition memory task (1 day after stimulation), participants' memory performance on these words and their subjective memory confidence were tested. Salivary alpha-amylase (sAA) levels, a putative indirect measure of central noradrenergic activation, were also measured before and after stimulation. During encoding, pleasant words were more accurately detected than neutral and unpleasant words. However, no tVNS effects were observed on task performance or on overall sAA level changes. tVNS also did not modulate overall recognition memory, which was particularly enhanced for pleasant emotional words. However, when hit rates were split based on confidence ratings reflecting familiarity- and recollection-based memory, higher recollection-based memory performance (irrespective of emotional category) was observed during active stimulation than during sham stimulation. To summarize, we replicated prior findings of enhanced processing and memory for emotional (pleasant) words. Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tVNS facilitates hippocampus-mediated consolidation processes.}, language = {en} } @misc{BreedveldFolkertsmaEccard2019, author = {Breedveld, Merel Cathelijne and Folkertsma, Remco and Eccard, Jana}, title = {Rodent mothers increase vigilance behaviour when facing infanticide risk}, series = {Postprints der Universit{\"a}t Potsdam Mathematisch- Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Mathematisch- Naturwissenschaftliche Reihe}, number = {766}, issn = {1866-8372}, doi = {10.25932/publishup-43807}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438074}, pages = {12}, year = {2019}, abstract = {Infanticide, the killing of unrelated young, is widespread and frequently driven by sexual conflict. especially in mammals with exclusive maternal care, infanticide by males is common and females suffer fitness costs. Recognizing infanticide risk and adjusting offspring protection accordingly should therefore be adaptive in female mammals. Using a small mammal (Myodes glareolus) in outdoor enclosures, we investigated whether lactating mothers adjust offspring protection, and potential mate search behaviour, in response to different infanticide risk levels. We presented the scent of the litter's sire or of a stranger male near the female's nest, and observed female nest presence and movement by radiotracking. While both scents simulated a mating opportunity, they represented lower (sire) and higher (stranger) infanticide risk. compared to the sire treatment, females in the stranger treatment left their nest more often, showed increased activity and stayed closer to the nest, suggesting offspring protection from outside the nest through elevated alertness and vigilance. females with larger litters spent more time investigating scents and used more space in the sire but not in the stranger treatment. Thus, current investment size affected odour inspection and resource acquisition under higher risk. Adjusting nest protection and resource acquisition to infanticide risk could allow mothers to elicit appropriate (fitness-saving) counterstrategies, and thus, may be widespread.}, language = {en} } @misc{BhataraLaukkaBollAvetisyanetal.2016, author = {Bhatara, Anjali and Laukka, Petri and Boll-Avetisyan, Natalie and Granjon, Lionel and Elfenbein, Hillary Anger and B{\"a}nziger, Tanja}, title = {Second language ability and emotional prosody perception}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {503}, issn = {1866-8364}, doi = {10.25932/publishup-41186}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-411860}, pages = {13}, year = {2016}, abstract = {The present study examines the effect of language experience on vocal emotion perception in a second language. Native speakers of French with varying levels of self-reported English ability were asked to identify emotions from vocal expressions produced by American actors in a forced-choice task, and to rate their pleasantness, power, alertness and intensity on continuous scales. Stimuli included emotionally expressive English speech (emotional prosody) and non-linguistic vocalizations (affect bursts), and a baseline condition with Swiss-French pseudo-speech. Results revealed effects of English ability on the recognition of emotions in English speech but not in non-linguistic vocalizations. Specifically, higher English ability was associated with less accurate identification of positive emotions, but not with the interpretation of negative emotions. Moreover, higher English ability was associated with lower ratings of pleasantness and power, again only for emotional prosody. This suggests that second language skills may sometimes interfere with emotion recognition from speech prosody, particularly for positive emotions.}, language = {en} } @misc{HempelKoseskaNikoloskietal.2017, author = {Hempel, Sabrina and Koseska, Aneta and Nikoloski, Zoran and Kurths, J{\"u}rgen}, title = {Unraveling gene regulatory networks from time-resolved gene expression data}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-400924}, pages = {26}, year = {2017}, abstract = {Background: Inferring regulatory interactions between genes from transcriptomics time-resolved data, yielding reverse engineered gene regulatory networks, is of paramount importance to systems biology and bioinformatics studies. Accurate methods to address this problem can ultimately provide a deeper insight into the complexity, behavior, and functions of the underlying biological systems. However, the large number of interacting genes coupled with short and often noisy time-resolved read-outs of the system renders the reverse engineering a challenging task. Therefore, the development and assessment of methods which are computationally efficient, robust against noise, applicable to short time series data, and preferably capable of reconstructing the directionality of the regulatory interactions remains a pressing research problem with valuable applications. Results: Here we perform the largest systematic analysis of a set of similarity measures and scoring schemes within the scope of the relevance network approach which are commonly used for gene regulatory network reconstruction from time series data. In addition, we define and analyze several novel measures and schemes which are particularly suitable for short transcriptomics time series. We also compare the considered 21 measures and 6 scoring schemes according to their ability to correctly reconstruct such networks from short time series data by calculating summary statistics based on the corresponding specificity and sensitivity. Our results demonstrate that rank and symbol based measures have the highest performance in inferring regulatory interactions. In addition, the proposed scoring scheme by asymmetric weighting has shown to be valuable in reducing the number of false positive interactions. On the other hand, Granger causality as well as information-theoretic measures, frequently used in inference of regulatory networks, show low performance on the short time series analyzed in this study. Conclusions: Our study is intended to serve as a guide for choosing a particular combination of similarity measures and scoring schemes suitable for reconstruction of gene regulatory networks from short time series data. We show that further improvement of algorithms for reverse engineering can be obtained if one considers measures that are rooted in the study of symbolic dynamics or ranks, in contrast to the application of common similarity measures which do not consider the temporal character of the employed data. Moreover, we establish that the asymmetric weighting scoring scheme together with symbol based measures (for low noise level) and rank based measures (for high noise level) are the most suitable choices.}, language = {en} } @misc{OlejkoCywińskiBald2016, author = {Olejko, Lydia and Cywiński, P. J. and Bald, Ilko}, title = {An ion-controlled four-color fluorescent telomeric switch on DNA origami structures}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95831}, pages = {10339 -- 10347}, year = {2016}, abstract = {The folding of single-stranded telomeric DNA into guanine (G) quadruplexes is a conformational change that plays a major role in sensing and drug targeting. The telomeric DNA can be placed on DNA origami nanostructures to make the folding process extremely selective for K+ ions even in the presence of high Na+ concentrations. Here, we demonstrate that the K+-selective G-quadruplex formation is reversible when using a cryptand to remove K+ from the G-quadruplex. We present a full characterization of the reversible switching between single-stranded telomeric DNA and G-quadruplex structures using F{\"o}rster resonance energy transfer (FRET) between the dyes fluorescein (FAM) and cyanine3 (Cy3). When attached to the DNA origami platform, the G-quadruplex switch can be incorporated into more complex photonic networks, which is demonstrated for a three-color and a four-color FRET cascade from FAM over Cy3 and Cy5 to IRDye700 with G-quadruplex-Cy3 acting as a switchable transmitter.}, language = {en} }