@misc{GechevHilleWoerdenbagetal.2014,
  author    = {Gechev, Tsanko S. and Hille, Jacques and Woerdenbag, Herman J. and Benina, Maria and Mehterov, Nikolay and Toneva, Valentina and Fernie, Alisdair R. and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {Natural products from resurrection plants: Potential for medical applications},
  series = {Biotechnology advances : an international review journal ; research reviews and patent abstracts},
  volume    = {32},
  journal   = {Biotechnology advances : an international review journal ; research reviews and patent abstracts},
  number    = {6},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0734-9750},
  doi       = {10.1016/j.biotechadv.2014.03.005},
  pages     = {1091 -- 1101},
  year      = {2014},
  abstract  = {Resurrection species are a group of land plants that can tolerate extreme desiccation of their vegetative tissues during harsh drought stress, and still quickly often within hours regain normal physiological and metabolic functions following rehydration. At the molecular level, this desiccation tolerance is attributed to basal cellular mechanisms including the constitutive expression of stress-associated genes and high levels of protective metabolites present already in the absence of stress, as well as to transcriptome and metabolome reconfigurations rapidly occurring during the initial phases of drought stress. Parts of this response are conferred by unique metabolites, including a diverse array of sugars, phenolic compounds, and polyols, some of which accumulate to high concentrations within the plant cell. In addition to drought stress, these metabolites are proposed to contribute to the protection against other abiotic stresses and to an increased oxidative stress tolerance. Recently, extracts of resurrection species and particular secondary metabolites therein were reported to display biological activities of importance to medicine, with e.g. antibacterial, anticancer, antifungal, and antiviral activities, rendering them possible candidates for the development of novel drug substances as well as for cosmetics. Herein, we provide an overview of the metabolite composition of resurrection species, summarize the latest reports related to the use of natural products from resurrection plants, and outline their potential for medical applications. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).},
  language  = {en}
}
@article{MachumiYenesewMidiwoetal.2012,
  author    = {Machumi, Francis and Yenesew, Abiy and Midiwo, Jacob O. and Heydenreich, Matthias and Kleinpeter, Erich and Tekwani, Babu L. and Khan, Shabana I. and Walker, Larry A. and Muhammad, Ilias},
  title     = {Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus},
  series = {Natural product communications : an international journal for communications and reviews},
  volume    = {7},
  journal   = {Natural product communications : an international journal for communications and reviews},
  number    = {9},
  publisher = {NPC},
  address   = {Westerville},
  issn      = {1934-578X},
  pages     = {1123 -- 1126},
  year      = {2012},
  abstract  = {The CH2Cl2-MeOH (1:1) extract of the aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7 mu g/mL) and chloroquine resistant W2 (IC50 15.0 mu g/mL) strains of Plasmodium falciparum. Seventeen secondary metabolites were isolated from the extract through conventional chromatographic techniques and identified using various spectroscopic methods. The compounds were evaluated for their in vitro antiplasmodial, antileishmanial and anticancer activities revealing activity of four carvotacetone derivatives, namely 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (1) 3,7-dihydroxy-5-tigloyloxycarvotacetone (2), 3-acetoxy-5,7-dihydroxycarvotacetone (3) and 3,5,7-trihydroxycarvotacetone (4); with antiplasmodial IC50 values of 1.40, 0.79, 0.60 and 3.40 mu g/mL, respectively, against chloroquine sensitive D6 strains of P. falciparum; antiplasmodial activity of IC50 2.00, 0.90, 0.68 and 2.80 mu g/mL respectively, against chloroquine resistant W2 strains of P. falciparum, antileishmanial IC50, values of 0.70, 3.00, 0.70 and 17.00 mu g/mL, respectively, against the parasite L. donovanii promastigotes, and anticancer activity against human SK-MEL, KB, BT-549 and SK-OV-3 tumor cells, with IC50 values between <1.1 - 5.3 mu g/mL, for 1-3. In addition, cytotoxic effects of the active compounds were evaluated against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11). The structures of carvotacetone derivatives were determined by ID and 2D NMR spectroscopy; the absolute stereochemical configuration of 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (I) was determined as 3R, 4R, 5S by circular dichroism, specific rotation, H-1 NMR and 2D NMR ROESY and NOESY experiments.},
  language  = {en}
}