@article{StubningDenesGerhard2021,
  author    = {Stubning, Tobias and Denes, Istvan and Gerhard, Reimund},
  title     = {Tuning electro-mechanical properties of EAP-based haptic actuators by adjusting layer thickness and number of stacked layers},
  series = {Engineering research express},
  volume    = {3},
  journal   = {Engineering research express},
  number    = {1},
  publisher = {Institute of Physics},
  address   = {London},
  issn      = {2631-8695},
  doi       = {10.1088/2631-8695/abd286},
  pages     = {13},
  year      = {2021},
  abstract  = {In our fast-changing world, human-machine interfaces (HMIs) are of ever-increasing importance. Among the most ubiquitous examples are touchscreens that most people are familiar with from their smartphones. The quality of such an HMI can be improved by adding haptic feedback-an imitation of using mechanical buttons-to the touchscreen. Thin-film actuators on the basis of electro-mechanically active polymers (EAPs), with the electroactive material sandwiched between two compliant electrodes, offer a promising technology for haptic surfaces. In thin-film technology, the thickness and the number of stacked layers of the electroactive dielectric are key parameters for tuning a system. Therefore, we have experimentally investigated the influence of the thickness of a single EAP layer on the electrical and the electro-mechanical performance of the transducer. In order to achieve high electro-mechanical actuator outputs, we have employed relaxor-ferroelectric ter-fluoropolymers that can be screen-printed. By means of a model-based approach, we have also directly compared single- and multi-layer actuators, thus providing guidelines for optimized transducer configurations with respect to the system requirements of haptic applications for which the operation frequency is of particular importance.},
  language  = {en}
}
@phdthesis{Grimbs2009,
  author    = {Grimbs, Sergio},
  title     = {Towards structure and dynamics of metabolic networks},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-32397},
  school      = {Universit{\"a}t Potsdam},
  year      = {2009},
  abstract  = {This work presents mathematical and computational approaches to cover various aspects of metabolic network modelling, especially regarding the limited availability of detailed kinetic knowledge on reaction rates. It is shown that precise mathematical formulations of problems are needed i) to find appropriate and, if possible, efficient algorithms to solve them, and ii) to determine the quality of the found approximate solutions. Furthermore, some means are introduced to gain insights on dynamic properties of metabolic networks either directly from the network structure or by additionally incorporating steady-state information. Finally, an approach to identify key reactions in a metabolic networks is introduced, which helps to develop simple yet useful kinetic models. The rise of novel techniques renders genome sequencing increasingly fast and cheap. In the near future, this will allow to analyze biological networks not only for species but also for individuals. Hence, automatic reconstruction of metabolic networks provides itself as a means for evaluating this huge amount of experimental data. A mathematical formulation as an optimization problem is presented, taking into account existing knowledge and experimental data as well as the probabilistic predictions of various bioinformatical methods. The reconstructed networks are optimized for having large connected components of high accuracy, hence avoiding fragmentation into small isolated subnetworks. The usefulness of this formalism is exemplified on the reconstruction of the sucrose biosynthesis pathway in Chlamydomonas reinhardtii. The problem is shown to be computationally demanding and therefore necessitates efficient approximation algorithms. The problem of minimal nutrient requirements for genome-scale metabolic networks is analyzed. Given a metabolic network and a set of target metabolites, the inverse scope problem has as it objective determining a minimal set of metabolites that have to be provided in order to produce the target metabolites. These target metabolites might stem from experimental measurements and therefore are known to be produced by the metabolic network under study, or are given as the desired end-products of a biotechological application. The inverse scope problem is shown to be computationally hard to solve. However, I assume that the complexity strongly depends on the number of directed cycles within the metabolic network. This might guide the development of efficient approximation algorithms. Assuming mass-action kinetics, chemical reaction network theory (CRNT) allows for eliciting conclusions about multistability directly from the structure of metabolic networks. Although CRNT is based on mass-action kinetics originally, it is shown how to incorporate further reaction schemes by emulating molecular enzyme mechanisms. CRNT is used to compare several models of the Calvin cycle, which differ in size and level of abstraction. Definite results are obtained for small models, but the available set of theorems and algorithms provided by CRNT can not be applied to larger models due to the computational limitations of the currently available implementations of the provided algorithms. Given the stoichiometry of a metabolic network together with steady-state fluxes and concentrations, structural kinetic modelling allows to analyze the dynamic behavior of the metabolic network, even if the explicit rate equations are not known. In particular, this sampling approach is used to study the stabilizing effects of allosteric regulation in a model of human erythrocytes. Furthermore, the reactions of that model can be ranked according to their impact on stability of the steady state. The most important reactions in that respect are identified as hexokinase, phosphofructokinase and pyruvate kinase, which are known to be highly regulated and almost irreversible. Kinetic modelling approaches using standard rate equations are compared and evaluated against reference models for erythrocytes and hepatocytes. The results from this simplified kinetic models can simulate acceptably the temporal behavior for small changes around a given steady state, but fail to capture important characteristics for larger changes. The aforementioned approach to rank reactions according to their influence on stability is used to identify a small number of key reactions. These reactions are modelled in detail, including knowledge about allosteric regulation, while all other reactions were still described by simplified reaction rates. These so-called hybrid models can capture the characteristics of the reference models significantly better than the simplified models alone. The resulting hybrid models might serve as a good starting point for kinetic modelling of genome-scale metabolic networks, as they provide reasonable results in the absence of experimental data, regarding, for instance, allosteric regulations, for a vast majority of enzymatic reactions.},
  language  = {en}
}
@article{MoradiCarminatiVetterleinetal.2011,
  author    = {Moradi, Ahmad B. and Carminati, Andrea and Vetterlein, Doris and Vontobel, Peter and Lehmann, Eberhard and Weller, Ulrich and Hopmans, Jan W. and Vogel, Hans-J{\"o}rg and Oswald, Sascha Eric},
  title     = {Three-dimensional visualization and quantification of water content in the rhizosphere},
  series = {New phytologist : international journal of plant science},
  volume    = {192},
  journal   = {New phytologist : international journal of plant science},
  number    = {3},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0028-646X},
  doi       = {10.1111/j.1469-8137.2011.03826.x},
  pages     = {653 -- 663},
  year      = {2011},
  abstract  = {Despite the importance of rhizosphere properties for water flow from soil to roots, there is limited quantitative information on the distribution of water in the rhizosphere of plants. Here, we used neutron tomography to quantify and visualize the water content in the rhizosphere of the plant species chickpea (Cicer arietinum), white lupin (Lupinus albus), and maize (Zea mays) 12 d after planting. We clearly observed increasing soil water contents (h) towards the root surface for all three plant species, as opposed to the usual assumption of decreasing water content. This was true for tap roots and lateral roots of both upper and lower parts of the root system. Furthermore, water gradients around the lower part of the roots were smaller and extended further into bulk soil compared with the upper part, where the gradients in water content were steeper. Incorporating the hydraulic conductivity and water retention parameters of the rhizosphere into our model, we could simulate the gradual changes of h towards the root surface, in agreement with the observations. The modelling result suggests that roots in their rhizosphere may modify the hydraulic properties of soil in a way that improves uptake under dry conditions.},
  language  = {en}
}
@phdthesis{RodriguezPiceda2022,
  author    = {Rodriguez Piceda, Constanza},
  title     = {Thermomechanical state of the southern Central Andes},
  doi       = {10.25932/publishup-54927},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-549275},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xx, 228},
  year      = {2022},
  abstract  = {The Andes are a ~7000 km long N-S trending mountain range developed along the South American western continental margin. Driven by the subduction of the oceanic Nazca plate beneath the continental South American plate, the formation of the northern and central parts of the orogen is a type case for a non-collisional orogeny. In the southern Central Andes (SCA, 29°S-39°S), the oceanic plate changes the subduction angle between 33°S and 35°S from almost horizontal (< 5° dip) in the north to a steeper angle (~30° dip) in the south. This sector of the Andes also displays remarkable along- and across- strike variations of the tectonic deformation patterns. These include a systematic decrease of topographic elevation, of crustal shortening and foreland and orogenic width, as well as an alternation of the foreland deformation style between thick-skinned and thin-skinned recorded along- and across the strike of the subduction zone. Moreover, the SCA are a very seismically active region. The continental plate is characterized by a relatively shallow seismicity (< 30 km depth) which is mainly focussed at the transition from the orogen to the lowland areas of the foreland and the forearc; in contrast, deeper seismicity occurs below the interiors of the northern foreland. Additionally, frequent seismicity is also recorded in the shallow parts of the oceanic plate and in a sector of the flat slab segment between 31°S and 33°S. The observed spatial heterogeneity in tectonic and seismic deformation in the SCA has been attributed to multiple causes, including variations in sediment thickness, the presence of inherited structures and changes in the subduction angle of the oceanic slab. However, there is no study that inquired the relationship between the long-term rheological configuration of the SCA and the spatial deformation patterns. Moreover, the effects of the density and thickness configuration of the continental plate and of variations in the slab dip angle in the rheological state of the lithosphere have been not thoroughly investigated yet. Since rheology depends on composition, pressure and temperature, a detailed characterization of the compositional, structural and thermal fields of the lithosphere is needed. Therefore, by using multiple geophysical approaches and data sources, I constructed the following 3D models of the SCA lithosphere: (i) a seismically-constrained structural and density model that was tested against the gravity field; (ii) a thermal model integrating the conversion of mantle shear-wave velocities to temperature with steady-state conductive calculations in the uppermost lithosphere (< 50 km depth), validated by temperature and heat-flow measurements; and (iii) a rheological model of the long-term lithospheric strength using as input the previously-generated models. The results of this dissertation indicate that the present-day thermal and rheological fields of the SCA are controlled by different mechanisms at different depths. At shallow depths (< 50 km), the thermomechanical field is modulated by the heterogeneous composition of the continental lithosphere. The overprint of the oceanic slab is detectable where the oceanic plate is shallow (< 85 km depth) and the radiogenic crust is thin, resulting in overall lower temperatures and higher strength compared to regions where the slab is steep and the radiogenic crust is thick. At depths > 50 km, largest temperatures variations occur where the descending slab is detected, which implies that the deep thermal field is mainly affected by the slab dip geometry. The outcomes of this thesis suggests that long-term thermomechanical state of the lithosphere influences the spatial distribution of seismic deformation. Most of the seismicity within the continental plate occurs above the modelled transition from brittle to ductile conditions. Additionally, there is a spatial correlation between the location of these events and the transition from the mechanically strong domains of the forearc and foreland to the weak domain of the orogen. In contrast, seismicity within the oceanic plate is also detected where long-term ductile conditions are expected. I therefore analysed the possible influence of additional mechanisms triggering these earthquakes, including the compaction of sediments in the subduction interface and dehydration reactions in the slab. To that aim, I carried out a qualitative analysis of the state of hydration in the mantle using the ratio between compressional- and shear-wave velocity (vp/vs ratio) from a previous seismic tomography. The results from this analysis indicate that the majority of the seismicity spatially correlates with hydrated areas of the slab and overlying continental mantle, with the exception of the cluster within the flat slab segment. In this region, earthquakes are likely triggered by flexural processes where the slab changes from a flat to a steep subduction angle. First-order variations in the observed tectonic patterns also seem to be influenced by the thermomechanical configuration of the lithosphere. The mechanically strong domains of the forearc and foreland, due to their resistance to deformation, display smaller amounts of shortening than the relatively weak orogenic domain. In addition, the structural and thermomechanical characteristics modelled in this dissertation confirm previous analyses from geodynamic models pointing to the control of the observed heterogeneities in the orogen and foreland deformation style. These characteristics include the lithospheric and crustal thickness, the presence of weak sediments and the variations in gravitational potential energy. Specific conditions occur in the cold and strong northern foreland, which is characterized by active seismicity and thick-skinned structures, although the modelled crustal strength exceeds the typical values of externally-applied tectonic stresses. The additional mechanisms that could explain the strain localization in a region that should resist deformation are: (i) increased tectonic forces coming from the steepening of the slab and (ii) enhanced weakening along inherited structures from pre-Andean deformation events. Finally, the thermomechanical conditions of this sector of the foreland could be a key factor influencing the preservation of the flat subduction angle at these latitudes of the SCA.},
  language  = {en}
}
@article{AyzelHeistermann2021,
  author    = {Ayzel, Georgy and Heistermann, Maik},
  title     = {The effect of calibration data length on the performance of a conceptual hydrological model versus LSTM and GRU},
  series = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology},
  volume    = {149},
  journal   = {Computers \& geosciences : an international journal devoted to the publication of papers on all aspects of geocomputation and to the distribution of computer programs and test data sets ; an official journal of the International Association for Mathematical Geology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0098-3004},
  doi       = {10.1016/j.cageo.2021.104708},
  pages     = {12},
  year      = {2021},
  abstract  = {We systematically explore the effect of calibration data length on the performance of a conceptual hydrological model, GR4H, in comparison to two Artificial Neural Network (ANN) architectures: Long Short-Term Memory Networks (LSTM) and Gated Recurrent Units (GRU), which have just recently been introduced to the field of hydrology. We implemented a case study for six river basins across the contiguous United States, with 25 years of meteorological and discharge data. Nine years were reserved for independent validation; two years were used as a warm-up period, one year for each of the calibration and validation periods, respectively; from the remaining 14 years, we sampled increasing amounts of data for model calibration, and found pronounced differences in model performance. While GR4H required less data to converge, LSTM and GRU caught up at a remarkable rate, considering their number of parameters. Also, LSTM and GRU exhibited the higher calibration instability in comparison to GR4H. These findings confirm the potential of modern deep-learning architectures in rainfall runoff modelling, but also highlight the noticeable differences between them in regard to the effect of calibration data length.},
  language  = {en}
}
@phdthesis{Raatz2019,
  author    = {Raatz, Michael},
  title     = {Strategies within predator-prey interactions - from individuals to ecosystems},
  doi       = {10.25932/publishup-42658},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426587},
  school      = {Universit{\"a}t Potsdam},
  pages     = {175},
  year      = {2019},
  abstract  = {Predator-prey interactions provide central links in food webs. These interaction are directly or indirectly impacted by a number of factors. These factors range from physiological characteristics of individual organisms, over specifics of their interaction to impacts of the environment. They may generate the potential for the application of different strategies by predators and prey. Within this thesis, I modelled predator-prey interactions and investigated a broad range of different factors driving the application of certain strategies, that affect the individuals or their populations. In doing so, I focused on phytoplankton-zooplankton systems as established model systems of predator-prey interactions. At the level of predator physiology I proposed, and partly confirmed, adaptations to fluctuating availability of co-limiting nutrients as beneficial strategies. These may allow to store ingested nutrients or to regulate the effort put into nutrient assimilation. We found that these two strategies are beneficial at different fluctuation frequencies of the nutrients, but may positively interact at intermediate frequencies. The corresponding experiments supported our model results. We found that the temporal structure of nutrient fluctuations indeed has strong effects on the juvenile somatic growth rate of {\itshape Daphnia}. Predator colimitation by energy and essential biochemical nutrients gave rise to another physiological strategy. High-quality prey species may render themselves indispensable in a scenario of predator-mediated coexistence by being the only source of essential biochemical nutrients, such as cholesterol. Thereby, the high-quality prey may even compensate for a lacking defense and ensure its persistence in competition with other more defended prey species. We found a similar effect in a model where algae and bacteria compete for nutrients. Now, being the only source of a compound that is required by the competitor (bacteria) prevented the competitive exclusion of the algae. In this case, the essential compounds were the organic carbon provided by the algae. Here again, being indispensable served as a prey strategy that ensured its coexistence. The latter scenario also gave rise to the application of the two metabolic strategies of autotrophy and heterotrophy by algae and bacteria, respectively. We found that their coexistence allowed the recycling of resources in a microbial loop that would otherwise be lost. Instead, these resources were made available to higher trophic levels, increasing the trophic transfer efficiency in food webs. The predation process comprises the next higher level of factors shaping the predator-prey interaction, besides these factors that originated from the functioning or composition of individuals. Here, I focused on defensive mechanisms and investigated multiple scenarios of static or adaptive combinations of prey defense and predator offense. I confirmed and extended earlier reports on the coexistence-promoting effects of partially lower palatability of the prey community. When bacteria and algae are coexisting, a higher palatability of bacteria may increase the average predator biomass, with the side effect of making the population dynamics more regular. This may facilitate experimental investigations and interpretations. If defense and offense are adaptive, this allows organisms to maximize their growth rate. Besides this fitness-enhancing effect, I found that co-adaptation may provide the predator-prey system with the flexibility to buffer external perturbations. On top of these rather internal factors, environmental drivers also affect predator-prey interactions. I showed that environmental nutrient fluctuations may create a spatio-temporal resource heterogeneity that selects for different predator strategies. I hypothesized that this might favour either storage or acclimation specialists, depending on the frequency of the environmental fluctuations. We found that many of these factors promote the coexistence of different strategies and may therefore support and sustain biodiversity. Thus, they might be relevant for the maintenance of crucial ecosystem functions that also affect us humans. Besides this, the richness of factors that impact predator-prey interactions might explain why so many species, especially in the planktonic regime, are able to coexist.},
  language  = {en}
}
@phdthesis{Mamede2008,
  author    = {Mamede, George Leite},
  title     = {Reservoir sedimentation in dryland catchments : modelling and management},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17047},
  school      = {Universit{\"a}t Potsdam},
  year      = {2008},
  abstract  = {Semi-arid environments are mainly characterized by scarce water resources and are usually subject to risks of water stress. In these regions, water supply for drinking and irrigation purposes depends strongly on storage in surface reservoirs and sediment deposition in these reservoirs affects adversely the water storage. In order to reproduce the complex behaviour of sediment deposition in reservoirs located in semi-arid environments and the effects of using sediment management techniques, a reservoir sedimentation model is developed and coupled within the WASA-SED model, which simulates rainfall-runoff processes and sediment transport at the hillslope and river network. The reservoir sedimentation model consists of two modelling approaches, which may be applied according to reservoir size and data availability. For reservoirs with information about their geometric features (reservoir topography, stage-area and stage-volume curves) and physical properties of sediment deposits, such as deposition thickness, grain size distribution of sediment deposits and sediment densities, a detailed modelling approach of reservoir sedimentation may be applied. For reservoirs without those characteristics, a simplified modelling approach is used. The detailed modelling approach of reservoir sedimentation enables the assessment of sediment deposition pattern in reservoirs and the evaluation of sediment release efficiency of sediment management techniques. It simulates sediment transport along the longitudinal profile of a reservoir. The reservoir is divided into cross sections to elaborate the sediment budget. The sediment transport component is calculated using a non-uniform sediment transport approach based on the concept of sediment carrying capacity. Four different sediment-transport equations can be selected for the simulations. The simplified modelling approach of reservoir sedimentation is suitable to simulate water and sediment transfer in dense reservoirs network. Nevertheless, it allows simulating neither sediment management techniques, nor spatial distribution of sedimentation. In this approach, the reservoirs are classified into small and strategic reservoirs according to their location and size. Strategic reservoirs are medium and large-sized reservoirs located on main rivers at the sub-basin's outlet or reservoirs of particular interest. The small reservoirs are located at tributary streams and represented in the model in an aggregate manner by grouping them into size classes according to their storage capacity. A cascade routing scheme is used to describe the upstream-downstream position of the reservoir classes. The water and sediment balances of small reservoirs are computed for one hypothetical representative reservoir of mean characteristics. Sediment trapping efficiency and effluent grain size distribution are estimated using the overflow rate concept. Three model applications are carried out within this research, as follows: • The detailed modelling approach of reservoir sedimentation is applied to the 92.2 Mm³ Barasona Reservoir, located in the foothills of the Central Pyrenees (Aragon, Spain). A two-stage calibration was performed to account for changes on the sediment deposition pattern caused by sediment management. The reservoir sedimentation model is then validated for another simulation period which confirms that the processes related to reservoir sedimentation are well represented by the model. • An application is carried out to the 933-km² Bengu{\^e} catchment, located in the semi-arid region of Northeast Brazil. The catchment is characterized by a dense reservoir network, covering almost 45\% of the catchment area, with a significant lack of data. Water and sediment balances of those reservoirs are computed using the simplified modelling approach. Three spatial configurations describing the cascade routing scheme are tested. • The reservoir sedimentation model is applied again to the Barasona reservoir to evaluate the sediment release efficiency of sediment management strategies. Cost analysis is presented to help in the choice of the most promising sediment management technique for that situation. Thus, the model enables the assessment of technical features of the sediment management strategies. Overall, simulation results are characterized by large uncertainties, partly due to low data availability and also due to uncertainties of the model structure to adequately represent the processes related to reservoir sedimentation.},
  language  = {de}
}
@article{vanSchaikBronstertdeJongetal.2014,
  author    = {van Schaik, N. Loes M. B. and Bronstert, Axel and de Jong, S. M. and Jetten, V. G. and van Dam, J. C. and Ritsema, C. J. and Schnabel, Susanne},
  title     = {Process-based modelling of a headwater catchment in a semi-arid area: the influence of macropore flow},
  series = {Hydrological processes},
  volume    = {28},
  journal   = {Hydrological processes},
  number    = {24},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0885-6087},
  doi       = {10.1002/hyp.10086},
  pages     = {5805 -- 5816},
  year      = {2014},
  abstract  = {Subsurface stormflow is thought to occur mainly in humid environments with steep terrains. However, in semi-arid areas, preferential flow through macropores can also result in a significant contribution of subsurface stormflow to catchment runoff for varying catchment conditions. Most hydrological models neglect this important subsurface preferential flow. Here, we use the process-oriented hydrological model Hillflow-3D, which includes a macropore flow approach, to simulate rainfall-runoff in the semi-arid Parapunos catchment in Spain, where macropore flow was observed in previous research. The model was extended for this study to account for sorptivity under very dry soil conditions. The results of the model simulations with and without macropore flow are compared. Both model versions give reasonable results for average rainfall situations, although the approach with the macropore concept provides slightly better results. The model results for scenarios of extreme rainfall events (>13.3mm30min(-1)) however show large differences between the versions with and without macropores. These model results compared with measured rainfall-runoff data show that the model with the macropore concept is better. Our conclusion is that preferential flow is important in controlling surface runoff in case of specific, high intensity rainfall events. Therefore, preferential flow processes must be included in hydrological models where we know that preferential flow occurs. Hydrological process models with a less detailed process description may fit observed average events reasonably well but can result in erroneous predictions for more extreme events. Copyright (c) 2013 John Wiley \& Sons, Ltd.},
  language  = {en}
}
@phdthesis{Fuhrmann2018,
  author    = {Fuhrmann, Saskia},
  title     = {Physiologically-based pharmacokinetic and mechanism-based pharmacodynamic modelling of monoclonal antibodies with a focus on tumour targeting},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418861},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xvii, 171},
  year      = {2018},
  abstract  = {Monoclonal antibodies (mAbs) are an innovative group of drugs with increasing clinical importance in oncology, combining high specificity with generally low toxicity. There are, however, numerous challenges associated with the development of mAbs as therapeutics. Mechanistic understanding of factors that govern the pharmacokinetics (PK) of mAbs is critical for drug development and the optimisation of effective therapies; in particular, adequate dosing strategies can improve patient quality life and lower drug cost. Physiologically-based PK (PBPK) models offer a physiological and mechanistic framework, which is of advantage in the context of animal to human extrapolation. Unlike for small molecule drugs, however, there is no consensus on how to model mAb disposition in a PBPK context. Current PBPK models for mAb PK hugely vary in their representation of physiology and parameterisation. Their complexity poses a challenge for their applications, e.g., translating knowledge from animal species to humans. In this thesis, we developed and validated a consensus PBPK model for mAb disposition taking into account recent insights into mAb distribution (antibody biodistribution coefficients and interstitial immunoglobulin G (IgG) pharmacokinetics) to predict tissue PK across several pre-clinical species and humans based on plasma data only. The model allows to a priori predict target-independent (unspecific) mAb disposition processes as well as mAb disposition in concentration ranges, for which the unspecific clearance (CL) dominates target-mediated CL processes. This is often the case for mAb therapies at steady state dosing. The consensus PBPK model was then used and refined to address two important problems: 1) Immunodeficient mice are crucial models to evaluate mAb efficacy in cancer therapy. Protection from elimination by binding to the neonatal Fc receptor is known to be a major pathway influencing the unspecific CL of both, endogenous and therapeutic IgG. The concentration of endogenous IgG, however, is reduced in immunodeficient mouse models, and this effect on unspecific mAb CL is unknown, yet of great importance for the extrapolation to human in the context of mAb cancer therapy. 2) The distribution of mAbs into solid tumours is of great interest. To comprehensively investigate mAb distribution within tumour tissue and its implications for therapeutic efficacy, we extended the consensus PBPK model by a detailed tumour distribution model incorporating a cell-level model for mAb-target interaction. We studied the impact of variations in tumour microenvironment on therapeutic efficacy and explored the plausibility of different mechanisms of action in mAb cancer therapy. The mathematical findings and observed phenomena shed new light on therapeutic utility and dosing regimens in mAb cancer treatment.},
  language  = {en}
}
@phdthesis{Hudjetz2013,
  author    = {Hudjetz, Annekatrin},
  title     = {Modelllernen im Ern{\"a}hrungskontext : m{\"u}tterlicher und v{\"a}terlicher Einfluss auf die Ern{\"a}hrung adip{\"o}ser Kinder},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-72336},
  school      = {Universit{\"a}t Potsdam},
  year      = {2013},
  abstract  = {Adipositas ist eine chronische Erkrankung mit erheblichen Komorbidit{\"a}ten und Folgesch{\"a}den, die bereits im Kindes- und Jugendalter weit verbreitet ist. Unterschiedliche Faktoren sind an der {\"A}tiologie dieser St{\"o}rung beteiligt. Die Ern{\"a}hrung stellt dabei eine der Haupts{\"a}ulen dar, auf welche immer wieder Bezug genommen wird. Der Einfluss der Eltern auf die kindliche Ern{\"a}hrung spielt unbestritten eine zentrale Rolle - hinsichtlich genetischer Dispositionen, aber auch als Gestalter der Lebensumwelten und Vorbilder im Ern{\"a}hrungsbereich. Die vorliegende Arbeit hat zum Ziel, {\"U}bereinstimmungen elterlicher und kindlicher Ern{\"a}hrung zu untersuchen und dabei zu pr{\"u}fen, inwiefern Prozesse des Modelllernens f{\"u}r die Zusammenh{\"a}nge verantwortlich zeichnen. Grundlage ist die sozial-kognitive Theorie Albert Banduras mit dem Fokus auf seinen Ausf{\"u}hrungen zum Beobachtungs- oder Modelllernen. Die Zusammenh{\"a}nge elterlicher und kindlicher Ern{\"a}hrung wurden anhand einer Stichprobe 7 - 13-j{\"a}hriger adip{\"o}ser Kinder und ihrer Eltern in Beziehung gesetzt zu den Bedingungen des Modelllernens, die zuvor auch in anderen Studien gefunden worden waren. Eine hohe {\"A}hnlichkeit oder gute Beziehung zwischen Modell (Mutter bzw. Vater) und Lernendem (Kind) sollte demnach moderierend auf die St{\"a}rke des Zusammenhangs wirken. Aus Banduras Ausf{\"u}hrungen zu den Phasen des Modelllernens ergibt sich zudem ein dritter Aspekt, der in das Untersuchungsmodell einbezogen wurde. Die von Bandura postulierte Aneignungsphase setzt voraus, dass das zu lernende Verhalten auch beobachtet werden kann. Aus diesem Grund sollte die Analyse von Zusammenh{\"a}ngen im Verhalten nicht losgel{\"o}st von der Zeit betrachtet werden, die Modell und Beobachter miteinander verbringen bzw. verbracht haben. Zudem wurde die Wahrnehmung eines Elternteils als Vorbild beim Kind erfragt und als Moderator aufgenommen. In die Analysen eingeschlossen wurden vollst{\"a}ndige Mutter-Vater-Kind-Triaden. Im Querschnitt der Fragebogenerhebung waren die Daten von 171 M{\"a}dchen und 176 Jungen, in einem 7 Monate darauf folgenden L{\"a}ngsschnitt insgesamt 75 Triaden (davon 38 M{\"a}dchen) enthalten. Es zeigte sich ein positiver Zusammenhang zwischen der kindlichen und m{\"u}tterlichen Ern{\"a}hrung ebenso wie zwischen der kindlichen und v{\"a}terlichen Ern{\"a}hrung. Die {\"U}bereinstimmungen zwischen Mutter und Kind waren gr{\"o}ßer als zwischen Vater und Kind. {\"U}berwiegend best{\"a}tigt werden konnten der moderierende Einfluss der Beziehungsqualit{\"a}t und der Vorbildwahrnehmung auf die Zusammenh{\"a}nge elterlicher und kindlicher gesunder Ern{\"a}hrung und der Einfluss gemeinsam verbrachter Zeit vor allem in Bezug auf Vater-Kind-Zusammenh{\"a}nge problematischer Ern{\"a}hrung. Der v{\"a}terliche Einfluss, der sowohl in Studien als auch in pr{\"a}ventiven oder therapeutischen Angeboten oft noch vernachl{\"a}ssigt wird und in vorliegender Arbeit besondere bzw. gleichberechtigte Beachtung fand, zeigte sich durch den Einbezug moderierender Variablen verst{\"a}rkt. Eine Ansprache von M{\"u}ttern und V{\"a}tern gleichermaßen ist somit unbedingtes Ziel bei der Pr{\"a}vention und Therapie kindlicher Adipositas. Auch jenseits des Adipositaskontextes sollten Eltern f{\"u}r die Bedeutung elterlicher Vorbildwirkung sensibilisiert werden, um eine gesunde Ern{\"a}hrungsweise ihrer Kinder zu f{\"o}rdern.},
  language  = {de}
}
@article{MarkowskaFohlmeisterTrebleetal.2019,
  author    = {Markowska, Monika and Fohlmeister, Jens Bernd and Treble, Pauline C. and Baker, Andy and Andersen, Martin S. and Hua, Quan},
  title     = {Modelling the C-14 bomb-pulse in young speleothems using a soil carbon continuum model},
  series = {Geochimica et cosmochimica acta : journal of the Geochemical Society and the Meteoritical Society},
  volume    = {261},
  journal   = {Geochimica et cosmochimica acta : journal of the Geochemical Society and the Meteoritical Society},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0016-7037},
  doi       = {10.1016/j.gca.2019.04.029},
  pages     = {342 -- 367},
  year      = {2019},
  abstract  = {The 'bomb-pulse' method is a chronological approach to further constrain the age of speleothems that grew between 1950 CE - present. Establishing dependable chronological constraints is crucial for modern calibration studies of speleothems to instrumental climate records, which provides the basis for paleoclimate interpretations. However, a large unknown is how 14C is transferred from the atmosphere to any individual speleothem owing to the site-specific residence times of organic matter above cave systems. Here, we employ the bomb-pulse method to build chronologies from 14C measurements in combination with a new unsaturated zone C model which considers C decomposition as a continuum, to better understand unsaturated zone 14C dynamics. The bomb-pulse curves of eight speleothems from southern Australia in three contrasting climatic regions; the semi-arid Wellington Caves site, the mediterranean Golgotha Cave site and the montane Yarrangobilly Caves site, are investigated. Overall, the modelled 14C bomb-pulse curves produce excellent fits with measured 14C speleothem data (r2 = 0.82-0.99). The C modelling reveals that unsaturated zone C is predominately young at the semi-arid site, with a weighted-mean residence time of 32 years and that tree root respiration is likely an important source of vadose CO2. At the montane site, ∼39\% of C is young (<1 years), but the weighted-mean C ages are older (145-220 years). The mediterranean site has very little contribution from young C (<12\%: 0-1 years), with weighted-mean ages between 157 and 245 years, likely due to greater adsorption of organic matter in the upper vadose zone during matrix flow, and remobilisation of C from young syngenetic karst. New end members for low speleothem Dead Carbon Proportion (DCP) are identified (2.19\% and 1.65\%, respectively) for Australian montane and semi-arid zone speleothems, where oversupply of modern CO2 in the vadose zone leads to lower DCP. It is also demonstrated that DCP can be quite variable over small time scales, that processes may be difficult to untangle and a constant DCP assumption is likely invalid. DCP variability over time is mainly controlled by the changes vadose zone CO2, where vegetation regeneration, wild-fires and karst hydrology play an important role.},
  language  = {en}
}
@phdthesis{Schroeder2015,
  author    = {Schr{\"o}der, Sarah},
  title     = {Modelling surface evolution coupled with tectonics},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-90385},
  school      = {Universit{\"a}t Potsdam},
  pages     = {viii, 129},
  year      = {2015},
  abstract  = {This study presents the development of 1D and 2D Surface Evolution Codes (SECs) and their coupling to any lithospheric-scale (thermo-)mechanical code with a quadrilateral structured surface mesh. Both SECs involve diffusion as approach for hillslope processes and the stream power law to reflect riverbed incision. The 1D SEC settles sediment that was produced by fluvial incision in the appropriate minimum, while the supply-limited 2D SEC DANSER uses a fast filling algorithm to model sedimantation. It is based on a cellular automaton. A slope-dependent factor in the sediment flux extends the diffusion equation to nonlinear diffusion. The discharge accumulation is achieved with the D8-algorithm and an improved drainage accumulation routine. Lateral incision enhances the incision's modelling. Following empirical laws, it incises channels of several cells width. The coupling method enables different temporal and spatial resolutions of the SEC and the thermo-mechanical code. It transfers vertical as well as horizontal displacements to the surface model. A weighted smoothing of the 3D surface displacements is implemented. The smoothed displacement vectors transmit the deformation by bilinear interpolation to the surface model. These interpolation methods ensure mass conservation in both directions and prevent the two surfaces from drifting apart. The presented applications refer to the evolution of the Pamir orogen. A calibration of DANSER's parameters with geomorphological data and a DEM as initial topography highlights the advantage of lateral incision. Preserving the channel width and reflecting incision peaks in narrow channels, this closes the huge gap between current orogen-scale incision models and observed topographies. River capturing models in a system of fault-bounded block rotations reaffirm the importance of the lateral incision routine for capturing events with channel initiation. The models show a low probability of river capturings with large deflection angles. While the probability of river capturing is directly depending on the uplift rate, the erodibility inside of a dip-slip fault speeds up headward erosion along the fault: The model's capturing speed increases within a fault. Coupling DANSER with the thermo-mechanical code SLIM 3D emphasizes the versatility of the SEC. While DANSER has minor influence on the lithospheric evolution of an indenter model, the brittle surface deformation is strongly affected by its sedimentation, widening a basin in between two forming orogens and also the southern part of the southern orogen to south, east and west.},
  language  = {en}
}
@phdthesis{Wriedt2004,
  author    = {Wriedt, Gunter},
  title     = {Modelling of nitrogen transport and turnover during soil and groundwater passage in a small lowland catchment of Northern Germany},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-0001307},
  school      = {Universit{\"a}t Potsdam},
  year      = {2004},
  abstract  = {Stoffumsatzreaktionen und hydraulische Prozesse im Boden und Grundwasser k{\"o}nnen in Tieflandeinzugsgebieten zu einer Nitratretention f{\"u}hren. Die Untersuchung dieser Prozesse in Raum und Zeit kann mit Hilfe geeigneter Modelle erfolgen. Ziele dieser Arbeit sind: i) die Entwicklung eines geeigneten Modellansatzes durch Kombination von Teilmodellen zur Simulation des N-Transportes im Boden und Grundwasser von Tieflandeinzugsgebieten und ii) die Untersuchung von Wechselwirkungen zwischen Gebietseigenschaften und N-Transport unter besonderer Ber{\"u}cksichtigung der potentiellen N-Zufuhr in die Oberfl{\"a}chengew{\"a}sser. Der Modellansatz basiert auf der Kombination verschiedener Teilmodelle: das Bodenwasser- und -stickstoffmodell mRISK-N, das Grundwassermodell MODFLOW und das Stofftransportmodell RT3D. Zur Untersuchung der Wechselwirkungen mit den Gebietseigenschaften muss die Verteilung und Verf{\"u}gbarkeit von Reaktionspartnern ber{\"u}cksichtigt werden. Dazu wurde ein Reaktionsmodul entwickelt, welches chemische Prozesse im Grundwasser simuliert. Hierzu geh{\"o}ren die Mineralisation organischer Substanz durch Sauerstoff, Nitrat und Sulfat sowie die Pyritoxidation durch Sauerstoff und Nitrat. Der Modellansatz wurde in verschiedenen Einzelstudien angewandt, wobei jeweils bestimmte Teilmodelle im Vordergrund stehen. Alle Modellstudien basieren auf Daten aus dem Schaugrabeneinzugsgebiet (ca. 25 km\&\#178;), in der N{\"a}he von Osterburg(Altmark) im Norden Sachsen-Anhalts. Die folgenden Einzelstudien wurden durchgef{\"u}hrt: i) Evaluation des Bodenmodells anhand von Lysimeterdaten, ii) Modellierung eines Tracerexperimentes im Feldmaßstab als eine erste Anwendung des Reaktionsmoduls, iii) Untersuchung hydraulisch-chemischer Wechselwirkungen an einem 2D-Grundwassertransekt, iv) Fl{\"a}chenverteilte Modellierung von Grundwasserneubildung und Bodenstickstoffaustrag im Untersuchungsgebiet als Eingangsdaten f{\"u}r nachfolgende Grundwassersimulationen, und v) Untersuchung der Ausbreitung von Nitrat im Grundwasser und des Durchbruchs in die Oberfl{\"a}chengew{\"a}sser im Untersuchungsgebiet auf Basis einer 3D-Modellierung von Grundwasserstr{\"o}mung und reaktivem Stofftransport. Die Modellstudien zeigen, dass der Modellansatz geeignet ist, die Wechselwirkungen zwischen Stofftransport und \&ndash;umsatz und den hydraulisch-chemischen Gebietseigenschaften zu modellieren. Die Ausbreitung von Nitrat im Sediment wird wesentlich von der Verf{\"u}gbarkeit reaktiver Substanzen sowie der Verweilzeit im Grundwasserleiter bestimmt. Bei der Simulation des Untersuchungsgebietes wurde erst nach 70 Jahren eine der gegebenen Eintragssitutation entsprechende Nitratkonzentration im Grundwasserzustrom zum Grabensystem erreicht (konservativer Transport). Die Ber{\"u}cksichtigung von reaktivem Stofftransport f{\"u}hrt zu einer deutlichen Reduktion der Nitratkonzentrationen. Die Modellergebnisse zeigen, dass der Grundwasserzustrom die beobachtete Nitratbelastung im Grabensystem nicht erkl{\"a}ren kann, da der Großteil des Nitrates durch Denitrifikation verloren geht. Andere Quellen, wie direkte Eintr{\"a}ge oder Dr{\"a}nagenzufl{\"u}sse m{\"u}ssen ebenfalls in Betracht gezogen werden. Die Prognosef{\"a}higkeit des Modells f{\"u}r das Untersuchungsgebiet wird durch die Datenunsicherheiten und die Sch{\"a}tzung der Modellparameter eingeschr{\"a}nkt. Dennoch ist der Modellansatz eine wertvolle Hilfe bei der Identifizierung von belastungsrelevanten Teilfl{\"a}chen (Stoffquellen und -senken) sowie bei der Modellierung der Auswirkungen von Managementmaßnahmen oder Landnutzungsver{\"a}nderungen auf Grundlage von Szenario-Simulationen. Der Modellansatz unterst{\"u}tzt auch die Interpretation von Beobachtungsdaten, da so die lokalen Informationen in einen r{\"a}umlichen und zeitlichen Zusammenhang gestellt werden k{\"o}nnen.},
  language  = {en}
}
@phdthesis{Brune2018,
  author    = {Brune, Sascha},
  title     = {Modelling continental rift dynamics},
  doi       = {10.25932/publishup-43236},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-432364},
  school      = {Universit{\"a}t Potsdam},
  pages     = {192},
  year      = {2018},
  abstract  = {Continental rift systems open up unique possibilities to study the geodynamic system of our planet: geodynamic localization processes are imprinted in the morphology of the rift by governing the time-dependent activity of faults, the topographic evolution of the rift or by controlling whether a rift is symmetric or asymmetric. Since lithospheric necking localizes strain towards the rift centre, deformation structures of previous rift phases are often well preserved and passive margins, the end product of continental rifting, retain key information about the tectonic history from rift inception to continental rupture. Current understanding of continental rift evolution is based on combining observations from active rifts with data collected at rifted margins. Connecting these isolated data sets is often accomplished in a conceptual way and leaves room for subjective interpretation. Geodynamic forward models, however, have the potential to link individual data sets in a quantitative manner, using additional constraints from rock mechanics and rheology, which allows to transcend previous conceptual models of rift evolution. By quantifying geodynamic processes within continental rifts, numerical modelling allows key insight to tectonic processes that operate also in other plate boundary settings, such as mid ocean ridges, collisional mountain chains or subduction zones. In this thesis, I combine numerical, plate-tectonic, analytical, and analogue modelling approaches, whereas numerical thermomechanical modelling constitutes the primary tool. This method advanced rapidly during the last two decades owing to dedicated software development and the availability of massively parallel computer facilities. Nevertheless, only recently the geodynamical modelling community was able to capture 3D lithospheric-scale rift dynamics from onset of extension to final continental rupture. The first chapter of this thesis provides a broad introduction to continental rifting, a summary of the applied rift modelling methods and a short overview of previews studies. The following chapters, which constitute the main part of this thesis feature studies on plate boundary dynamics in two and three dimension followed by global scale analyses (Fig. 1). Chapter II focuses on 2D geodynamic modelling of rifted margin formation. It highlights the formation of wide areas of hyperextended crustal slivers via rift migration as a key process that affected many rifted margins worldwide. This chapter also contains a study of rift velocity evolution, showing that rift strength loss and extension velocity are linked through a dynamic feed-back. This process results in abrupt accelerations of the involved plates during rifting illustrating for the first time that rift dynamics plays a role in changing global-scale plate motions. Since rift velocity affects key processes like faulting, melting and lower crustal flow, this study also implies that the slow-fast velocity evolution should be imprinted in rifted margin structures. Chapter III relies on 3D Cartesian rift models in order to investigate various aspects of rift obliquity. Oblique rifting occurs if the extension direction is not orthogonal to the rift trend. Using 3D lithospheric-scale models from rift initialisation to breakup I could isolate a characteristic evolution of dominant fault orientations. Further work in Chapter III addresses the impact of rift obliquity on the strength of the rift system. We illustrate that oblique rifting is mechanically preferred over orthogonal rifting, because the brittle yielding requires a lower tectonic force. This mechanism elucidates rift competition during South Atlantic rifting, where the more oblique Equatorial Atlantic Rift proceeded to breakup while the simultaneously active but less oblique West African rift system became a failed rift. Finally this Chapter also investigates the impact of a previous rift phase on current tectonic activity in the linkage area of the Kenyan with Ethiopian rift. We show that the along strike changes in rift style are not caused by changes in crustal rheology. Instead the rift linkage pattern in this area can be explained when accounting for the thinned crust and lithosphere of a Mesozoic rift event. Chapter IV investigates rifting from the global perspective. A first study extends the oblique rift topic of the previous chapter to global scale by investigating the frequency of oblique rifting during the last 230 million years. We find that approximately 70\% of all ocean-forming rift segments involved an oblique component of extension where obliquities exceed 20°. This highlights the relevance of 3D approaches in modelling, surveying, and interpretation of many rifted margins. In a final study, we propose a link between continental rift activity, diffuse CO2 degassing and Mesozoic/Cenozoic climate changes. We used recent CO2 flux measurements in continental rifts to estimate worldwide rift-related CO2 release, which we based on the global extent of rifts through time. The first-order correlation to paleo-atmospheric CO2 proxy data suggests that rifts constitute a major element of the global carbon cycle.},
  language  = {en}
}
@phdthesis{Francke2009,
  author    = {Francke, Till},
  title     = {Measurement and modelling of water and sediment fluxes in meso-scale dryland catchments},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31525},
  school      = {Universit{\"a}t Potsdam},
  year      = {2009},
  abstract  = {Water shortage is a serious threat for many societies worldwide. In drylands, water management measures like the construction of reservoirs are affected by eroded sediments transported in the rivers. Thus, the capability of assessing water and sediment fluxes at the river basin scale is of vital importance to support management decisions and policy making. This subject was addressed by the DFG-funded SESAM-project (Sediment Export from large Semi-Arid catchments: Measurements and Modelling). As a part of this project, this thesis focuses on (1) the development and implementation of an erosion module for a meso-scale catchment model, (2) the development of upscaling and generalization methods for the parameterization of such model, (3) the execution of measurements to obtain data required for the modelling and (4) the application of the model to different study areas and its evaluation. The research was carried out in two meso-scale dryland catchments in NE-Spain: Ribera Salada (200 km²) and Is{\´a}bena (450 km²). Adressing objective 1, WASA-SED, a spatially semi-distributed model for water and sediment transport at the meso-scale was developed. The model simulates runoff and erosion processes at the hillslope scale, transport processes of suspended and bedload fluxes in the river reaches, and retention and remobilisation processes of sediments in reservoirs. This thesis introduces the model concept, presents current model applications and discusses its capabilities and limitations. Modelling at larger scales faces the dilemma of describing relevant processes while maintaining a manageable demand for input data and computation time. WASA-SED addresses this challenge by employing an innovative catena-based upscaling approach: the landscape is represented by characteristic toposequences. For deriving these toposequences with regard to multiple attributes (eg. topography, soils, vegetation) the LUMP-algorithm (Landscape Unit Mapping Program) was developed and related to objective 2. It incorporates an algorithm to retrieve representative catenas and their attributes, based on a Digital Elevation Model and supplemental spatial data. These catenas are classified to provide the discretization for the WASA-SED model. For objective 3, water and sediment fluxes were monitored at the catchment outlet of the Is{\´a}bena and some of its sub-catchments. For sediment yield estimation, the intermittent measurements of suspended sediment concentration (SSC) had to be interpolated. This thesis presents a comparison of traditional sediment rating curves (SRCs), generalized linear models (GLMs) and non-parametric regression using Random Forests (RF) and Quantile Regression Forests (QRF). The observed SSCs are highly variable and range over six orders of magnitude. For these data, traditional SRCs performed poorly, as did GLMs, despite including other relevant process variables (e.g. rainfall intensities, discharge characteristics). RF and QRF proved to be very robust and performed favourably for reproducing sediment dynamics. QRF additionally excels in providing estimates on the accuracy of the predictions. Subsequent analysis showed that most of the sediment was exported during intense storms of late summer. Later floods yielded successively less sediment. Comparing sediment generation to yield at the outlet suggested considerable storage effects within the river channel. Addressing objective 4, the WASA-SED model was parameterized for the two study areas in NE Spain and applied with different foci. For Ribera Salada, the uncalibrated model yielded reasonable results for runoff and sediment. It provided quantitative measures of the change in runoff and sediment yield for different land-uses. Additional land management scenarios were presented and compared to impacts caused by climate change projections. In contrast, the application for the Is{\´a}bena focussed on exploring the full potential of the model's predictive capabilities. The calibrated model achieved an acceptable performance for the validation period in terms of water and sediment fluxes. The inadequate representation of the lower sub-catchments inflicted considerable reductions on model performance, while results for the headwater catchments showed good agreement despite stark contrasts in sediment yield. In summary, the application of WASA-SED to three catchments proved the model framework to be a practicable multi-scale approach. It successfully links the hillslope to the catchment scale and integrates the three components hillslope, river and reservoir in one model. Thus, it provides a feasible approach for tackling issues of water and sediment yield at the meso-scale. The crucial role of processes like transmission losses and sediment storage in the river has been identified. Further advances can be expected when the representation of connectivity of water and sediment fluxes (intra-hillslope, hillslope-river, intra-river) is refined and input data improves.},
  language  = {en}
}
@misc{RodriguezPicedaScheckWenderothGomezDacaletal.2020,
  author    = {Rodriguez Piceda, Constanza and Scheck Wenderoth, Magdalena and Gomez Dacal, Maria Laura and Bott, Judith and Prezzi, Claudia Beatriz and Strecker, Manfred},
  title     = {Lithospheric density structure of the southern Central Andes constrained by 3D data-integrative gravity modelling},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {7},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-56262},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-562628},
  pages     = {29},
  year      = {2020},
  abstract  = {The southern Central Andes (SCA) (between 27 degrees S and 40 degrees S) is bordered to the west by the convergent margin between the continental South American Plate and the oceanic Nazca Plate. The subduction angle along this margin is variable, as is the deformation of the upper plate. Between 33 degrees S and 35 degrees S, the subduction angle of the Nazca plate increases from sub-horizontal (< 5 degrees) in the north to relatively steep (similar to 30 degrees) in the south. The SCA contain inherited lithological and structural heterogeneities within the crust that have been reactivated and overprinted since the onset of subduction and associated Cenozoic deformation within the Andean orogen. The distribution of the deformation within the SCA has often been attributed to the variations in the subduction angle and the reactivation of these inherited heterogeneities. However, the possible influence that the thickness and composition of the continental crust have had on both short-term and long-term deformation of the SCA is yet to be thoroughly investigated. For our investigations, we have derived density distributions and thicknesses for various layers that make up the lithosphere and evaluated their relationships with tectonic events that occurred over the history of the Andean orogeny and, in particular, investigated the short- and long-term nature of the present-day deformation processes. We established a 3D model of lithosphere beneath the orogen and its foreland (29 degrees S-39 degrees S) that is consistent with currently available geological and geophysical data, including the gravity data. The modelled crustal configuration and density distribution reveal spatial relationships with different tectonic domains: the crystalline crust in the orogen (the magmatic arc and the main orogenic wedge) is thicker (similar to 55 km) and less dense (similar to 2900 kg/m(3)) than in the forearc (similar to 35 km, similar to 2975 kg/m(3)) and foreland (similar to 30 km, similar to 3000 kg/m(3)). Crustal thickening in the orogen probably occurred as a result of stacking of low-density domains, while density and thickness variations beneath the forearc and foreland most likely reflect differences in the tectonic evolution of each area following crustal accretion. No clear spatial relationship exists between the density distribution within the lithosphere and previously proposed boundaries of crustal terranes accreted during the early Paleozoic. Areas with ongoing deformation show a spatial correlation with those areas that have the highest topographic gradients and where there are abrupt changes in the average crustal-density contrast. This suggests that the short-term deformation within the interior of the Andean orogen and its foreland is fundamentally influenced by the crustal composition and the relative thickness of different crustal layers. A thicker, denser, and potentially stronger lithosphere beneath the northern part of the SCA foreland is interpreted to have favoured a strong coupling between the Nazca and South American plates, facilitating the development of a sub-horizontal slab.},
  language  = {en}
}
@article{RodriguezPicedaScheckWenderothGomezDacaletal.2020,
  author    = {Rodriguez Piceda, Constanza and Scheck Wenderoth, Magdalena and Gomez Dacal, Maria Laura and Bott, Judith and Prezzi, Claudia Beatriz and Strecker, Manfred},
  title     = {Lithospheric density structure of the southern Central Andes constrained by 3D data-integrative gravity modelling},
  series = {International journal of earth sciences},
  volume    = {110},
  journal   = {International journal of earth sciences},
  number    = {7},
  publisher = {Springer},
  address   = {New York},
  issn      = {1437-3254},
  doi       = {10.1007/s00531-020-01962-1},
  pages     = {2333 -- 2359},
  year      = {2020},
  abstract  = {The southern Central Andes (SCA) (between 27 degrees S and 40 degrees S) is bordered to the west by the convergent margin between the continental South American Plate and the oceanic Nazca Plate. The subduction angle along this margin is variable, as is the deformation of the upper plate. Between 33 degrees S and 35 degrees S, the subduction angle of the Nazca plate increases from sub-horizontal (< 5 degrees) in the north to relatively steep (similar to 30 degrees) in the south. The SCA contain inherited lithological and structural heterogeneities within the crust that have been reactivated and overprinted since the onset of subduction and associated Cenozoic deformation within the Andean orogen. The distribution of the deformation within the SCA has often been attributed to the variations in the subduction angle and the reactivation of these inherited heterogeneities. However, the possible influence that the thickness and composition of the continental crust have had on both short-term and long-term deformation of the SCA is yet to be thoroughly investigated. For our investigations, we have derived density distributions and thicknesses for various layers that make up the lithosphere and evaluated their relationships with tectonic events that occurred over the history of the Andean orogeny and, in particular, investigated the short- and long-term nature of the present-day deformation processes. We established a 3D model of lithosphere beneath the orogen and its foreland (29 degrees S-39 degrees S) that is consistent with currently available geological and geophysical data, including the gravity data. The modelled crustal configuration and density distribution reveal spatial relationships with different tectonic domains: the crystalline crust in the orogen (the magmatic arc and the main orogenic wedge) is thicker (similar to 55 km) and less dense (similar to 2900 kg/m(3)) than in the forearc (similar to 35 km, similar to 2975 kg/m(3)) and foreland (similar to 30 km, similar to 3000 kg/m(3)). Crustal thickening in the orogen probably occurred as a result of stacking of low-density domains, while density and thickness variations beneath the forearc and foreland most likely reflect differences in the tectonic evolution of each area following crustal accretion. No clear spatial relationship exists between the density distribution within the lithosphere and previously proposed boundaries of crustal terranes accreted during the early Paleozoic. Areas with ongoing deformation show a spatial correlation with those areas that have the highest topographic gradients and where there are abrupt changes in the average crustal-density contrast. This suggests that the short-term deformation within the interior of the Andean orogen and its foreland is fundamentally influenced by the crustal composition and the relative thickness of different crustal layers. A thicker, denser, and potentially stronger lithosphere beneath the northern part of the SCA foreland is interpreted to have favoured a strong coupling between the Nazca and South American plates, facilitating the development of a sub-horizontal slab.},
  language  = {en}
}
@phdthesis{Wagner2004,
  author    = {Wagner, Anja},
  title     = {Konzeption und Aufbau eines Geoinformationssystems zur Modellierung und Simulation von Offenlandschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-0001411},
  school      = {Universit{\"a}t Potsdam},
  year      = {2004},
  abstract  = {Zwischen 1990 und 1994 wurden rund 1000 Liegenschaften, die in der ehemaligen DDR von der Sowjetarmee und der NVA f{\"u}r milit{\"a}rische {\"U}bungen genutzt wurden, an Bund und L{\"a}nder {\"u}bergeben. Die gr{\"o}ßten Truppen{\"u}bungspl{\"a}tze liegen in Brandenburg und sind heute teilweise in Großschutzgebiete integriert, andere Pl{\"a}tze werden von der Bundeswehr weiterhin aktiv genutzt. Aufgrund des milit{\"a}rischen Betriebs sind die B{\"o}den dieser Truppen{\"u}bungspl{\"a}tze oft durch Blindg{\"a}nger, Munitionsreste, Treibstoff- und Schmier{\"o}lreste bis hin zu chemischen Kampfstoffen belastet. Allerdings existieren auf fast allen Liegenschaften neben diesen durch Munition und milit{\"a}rische {\"U}bungen belasteten Bereichen auch naturschutzfachlich wertvolle Fl{\"a}chen; gerade in den Offenlandbereichen kann dies durchaus mit einer Belastung durch Kampfmittel einhergehen. Charakteristisch f{\"u}r diese offenen Fl{\"a}chen, zu denen u.a. Zwergstrauchheiden, Trockenrasen, w{\"u}sten{\"a}hnliche Sandfl{\"a}chen und andere n{\"a}hrstoffarme baumlose Lebensr{\"a}ume geh{\"o}ren, sind Großfl{\"a}chigkeit, Abgeschiedenheit sowie ihre besondere Nutzung und Bewirtschaftung, d.h. die Abwesenheit von land- und forstwirtschaftlichem Betrieb sowie von Siedlungsfl{\"a}chen. Diese Charakteristik war die Grundlage f{\"u}r die Entwicklung einer speziell angepassten Flora und Fauna. Nach Beendigung des Milit{\"a}rbetriebs setzte dann in weiten Teilen eine großfl{\"a}chige Sukzession \&ndash; die allm{\"a}hliche Ver{\"a}nderung der Zusammensetzung von Pflanzen- und Tiergesellschaften \&ndash; ein, die diese offenen Bereiche teilweise bereits in Wald verwandelte und somit verschwinden ließ. Dies wiederum f{\"u}hrte zum Verlust der an diese Offenlandfl{\"a}chen gebundenen Tier- und Pflanzenarten. Zur Erhaltung, Gestaltung und Entwicklung dieser offenen Fl{\"a}chen wurden daher von einer interdisziplin{\"a}ren Gruppe von Naturwissenschaftlern verschiedene Methoden und Konzepte auf ihre jeweilige Wirksamkeit untersucht. So konnten schließlich die f{\"u}r die jeweiligen Standortbedingungen geeigneten Maßnahmen eingeleitet werden. Voraussetzung f{\"u}r die Einleitung der Maßnahmen sind zum einen Kenntnisse zu diesen jeweiligen Standortbedingungen, d.h. zum Ist-Zustand, sowie zur Entwicklung der Fl{\"a}chen, d.h. zur Dynamik. So kann eine Absch{\"a}tzung {\"u}ber die zuk{\"u}nftige Fl{\"a}chenentwicklung getroffen werden, damit ein effizienter Maßnahmeneinsatz stattfinden kann. Geoinformationssysteme (GIS) spielen dabei eine entscheidende Rolle zur digitalen Dokumentation der Biotop- und Nutzungstypen, da sie die M{\"o}glichkeit bieten, raum- und zeitbezogene Geometrie- und Sachdaten in großen Mengen zu verarbeiten. Daher wurde ein fachspezifisches GIS f{\"u}r Truppen{\"u}bungspl{\"a}tze entwickelt und implementiert. Die Aufgaben umfassten die Konzeption der Datenbank und des Objektmodells sowie fachspezifischer Modellierungs-, Analyse- und Pr{\"a}sentationsfunktionen. F{\"u}r die Integration von Fachdaten in die GIS-Datenbank wurde zudem ein Metadatenkatalog entwickelt, der in Form eines zus{\"a}tzlichen GIS-Tools verf{\"u}gbar ist. Die Basisdaten f{\"u}r das GIS wurden aus Fernerkundungsdaten, topographischen Karten sowie Gel{\"a}ndekartierungen gewonnen. Als Instrument f{\"u}r die Absch{\"a}tzung der zuk{\"u}nftigen Entwicklung wurde das Simulationstool AST4D entwickelt, in dem sowohl die Nutzung der (Raster-)Daten des GIS als Ausgangsdaten f{\"u}r die Simulationen als auch die Nutzung der Simulationsergebnisse im GIS m{\"o}glich ist. Zudem k{\"o}nnen die Daten in AST4D raumbezogen visualisiert werden. Das mathematische Konstrukt f{\"u}r das Tool war ein so genannter Zellul{\"a}rer Automat, mit dem die Fl{\"a}chenentwicklung unter verschiedenen Voraussetzungen simuliert werden kann. So war die Bildung verschiedener Szenarien m{\"o}glich, d.h. die Simulation der Fl{\"a}chenentwicklung mit verschiedenen (bekannten) Eingangsparametern und den daraus resultierenden unterschiedlichen (unbekannten) Endzust{\"a}nden. Vor der Durchf{\"u}hrung einer der drei in AST4D m{\"o}glichen Simulationsstufen k{\"o}nnen angepasst an das jeweilige Untersuchungsgebiet benutzerspezifische Festlegungen getroffen werden.},
  language  = {de}
}
@article{AichnerMakhmudovRajabovetal.2019,
  author    = {Aichner, Bernhard and Makhmudov, Zafar and Rajabov, Iljomjon and Zhang, Qiong and Pausata, Francesco Salvatore R. and Werner, Martin and Heinecke, Liv and Kuessner, Marie L. and Feakins, Sarah J. and Sachse, Dirk and Mischke, Steffen},
  title     = {Hydroclimate in the Pamirs Was Driven by Changes in Precipitation-Evaporation Seasonality Since theLast Glacial Period},
  series = {Geophysical research letters},
  volume    = {46},
  journal   = {Geophysical research letters},
  number    = {23},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {0094-8276},
  doi       = {10.1029/2019GL085202},
  pages     = {13972 -- 13983},
  year      = {2019},
  abstract  = {The Central Asian Pamir Mountains (Pamirs) are a high-altitude region sensitive to climatic change, with only few paleoclimatic records available. To examine the glacial-interglacial hydrological changes in the region, we analyzed the geochemical parameters of a 31-kyr record from Lake Karakul and performed a set of experiments with climate models to interpret the results. delta D values of terrestrial biomarkers showed insolation-driven trends reflecting major shifts of water vapor sources. For aquatic biomarkers, positive delta D shifts driven by changes in precipitation seasonality were observed at ca. 31-30, 28-26, and 17-14 kyr BP. Multiproxy paleoecological data and modelling results suggest that increased water availability, induced by decreased summer evaporation, triggered higher lake levels during those episodes, possibly synchronous to northern hemispheric rapid climate events. We conclude that seasonal changes in precipitation-evaporation balance significantly influenced the hydrological state of a large waterbody such as Lake Karakul, while annual precipitation amount and inflows remained fairly constant.},
  language  = {en}
}
@phdthesis{Kath2022,
  author    = {Kath, Nadja Jeanette},
  title     = {Functional traits determine biomass dynamics, coexistence and energetics in plankton food webs},
  doi       = {10.25932/publishup-55123},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-551239},
  school      = {Universit{\"a}t Potsdam},
  pages     = {197},
  year      = {2022},
  abstract  = {Plankton food webs are the basis of marine and limnetic ecosystems. Especially aquatic ecosystems of high biodiversity provide important ecosystem services for humankind as providers of food, coastal protection, climate regulation, and tourism. Understanding the dynamics of biomass and coexistence in these food webs is a first step to understanding the ecosystems. It also lays the foundation for the development of management strategies for the maintenance of the marine and freshwater biodiversity despite anthropogenic influences. Natural food webs are highly complex, and thus often equally complex methods are needed to analyse and understand them well. Models can help to do so as they depict simplified parts of reality. In the attempt to get a broader understanding of the complex food webs, diverse methods are used to investigate different questions. In my first project, we compared the energetics of a food chain in two versions of an allometric trophic network model. In particular, we solved the problem of unrealistically high trophic transfer efficiencies (up to 70\%) by accounting for both basal respiration and activity respiration, which decreased the trophic transfer efficiency to realistic values of ≤30\%. Next in my second project I turned to plankton food webs and especially phytoplankton traits. Investigating a long-term data set from Lake Constance we found evidence for a trade-off between defence and growth rate in this natural phytoplankton community. I continued working with this data set in my third project focusing on ciliates, the main grazer of phytoplankton in spring. Boosted regression trees revealed that temperature and predators have the highest influence on net growth rates of ciliates. We finally investigated in my fourth project a food web model inspired by ciliates to explore the coexistence of plastic competitors and to study the new concept of maladaptive switching, which revealed some drawbacks of plasticity: faster adaptation led to higher maladaptive switching towards undefended phenotypes which reduced autotroph biomass and coexistence and increased consumer biomass. It became obvious that even well-established models should be critically questioned as it is important not to forget reality on the way to a simplistic model. The results showed furthermore that long-term data sets are necessary as they can help to disentangle complex natural processes. Last, one should keep in mind that the interplay between models and experiments/ field data can deliver fruitful insights about our complex world.},
  language  = {en}
}
@misc{EldridgeŁangowskiStaceyetal.2016,
  author    = {Eldridge, Tilly and Łangowski, Łukasz and Stacey, Nicola and Jantzen, Friederike and Moubayidin, Laila and Sicard, Adrien and Southam, Paul and Kennaway, Richard and Lenhard, Michael and Coen, Enrico S. and {\O}stergaard, Lars},
  title     = {Fruit shape diversity in the Brassicaceae is generated by varying patterns of anisotropy},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {986},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43804},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438041},
  pages     = {3394 -- 3406},
  year      = {2016},
  abstract  = {Fruits exhibit a vast array of different 3D shapes, from simple spheres and cylinders to more complex curved forms; however, the mechanism by which growth is oriented and coordinated to generate this diversity of forms is unclear. Here, we compare the growth patterns and orientations for two very different fruit shapes in the Brassicaceae: the heart-shaped Capsella rubella silicle and the near-cylindrical Arabidopsis thaliana silique. We show, through a combination of clonal and morphological analyses, that the different shapes involve different patterns of anisotropic growth during three phases. These experimental data can be accounted for by a tissue level model in which specified growth rates vary in space and time and are oriented by a proximodistal polarity field. The resulting tissue conflicts lead to deformation of the tissue as it grows. The model allows us to identify tissue-specific and temporally specific activities required to obtain the individual shapes. One such activity may be provided by the valve-identity gene FRUITFULL, which we show through comparative mutant analysis to modulate fruit shape during post-fertilisation growth of both species. Simple modulations of the model presented here can also broadly account for the variety of shapes in other Brassicaceae species, thus providing a simplified framework for fruit development and shape diversity.},
  language  = {en}
}
@article{KloseChaparroSchillingetal.2020,
  author    = {Klose, Tim and Chaparro, M. Carme and Schilling, Frank and Butscher, Christoph and Klumbach, Steffen and Blum, Philipp},
  title     = {Fluid flow simulations of a large-scale borehole leakage experiment},
  series = {Transport in Porous Media},
  volume    = {136},
  journal   = {Transport in Porous Media},
  number    = {1},
  publisher = {Springer},
  address   = {New York},
  issn      = {0169-3913},
  doi       = {10.1007/s11242-020-01504-y},
  pages     = {125 -- 145},
  year      = {2020},
  abstract  = {Borehole leakage is a common and complex issue. Understanding the fluid flow characteristics of a cemented area inside a borehole is crucial to monitor and quantify the wellbore integrity as well as to find solutions to minimise existing leakages. In order to improve our understanding of the flow behaviour of cemented boreholes, we investigated experimental data of a large-scale borehole leakage tests by means of numerical modelling using three different conceptual models. The experiment was performed with an autoclave system consisting of two vessels bridged by a cement-filled casing. After a partial bleed-off at the well-head, a sustained casing pressure was observed due to fluid flow through the cementsteel composite. The aim of our simulations is to investigate and quantify the permeability of the cement-steel composite. From our model results, we conclude that the flow occurred along a preferential flow path at the cement-steel interface. Thus, the inner part of the cement core was impermeable during the duration of the experiment. The preferential flow path can be described as a highly permeable and highly porous area with an aperture of about 5 mu m and a permeability of 3 . 10(-12) m(2) (3 Darcy). It follows that the fluid flow characteristics of a cemented area inside a borehole cannot be described using one permeability value for the entire cement-steel composite. Furthermore, it can be concluded that the quality of the cement and the filling process regarding the cement-steel interface is crucial to minimize possible well leakages.},
  language  = {en}
}
@misc{KloseChaparroSchillingetal.2020,
  author    = {Klose, Tim and Chaparro, M. Carme and Schilling, Frank and Butscher, Christoph and Klumbach, Steffen and Blum, Philipp},
  title     = {Fluid flow simulations of a large-scale borehole leakage experiment},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-57353},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-573539},
  pages     = {23},
  year      = {2020},
  abstract  = {Borehole leakage is a common and complex issue. Understanding the fluid flow characteristics of a cemented area inside a borehole is crucial to monitor and quantify the wellbore integrity as well as to find solutions to minimise existing leakages. In order to improve our understanding of the flow behaviour of cemented boreholes, we investigated experimental data of a large-scale borehole leakage tests by means of numerical modelling using three different conceptual models. The experiment was performed with an autoclave system consisting of two vessels bridged by a cement-filled casing. After a partial bleed-off at the well-head, a sustained casing pressure was observed due to fluid flow through the cementsteel composite. The aim of our simulations is to investigate and quantify the permeability of the cement-steel composite. From our model results, we conclude that the flow occurred along a preferential flow path at the cement-steel interface. Thus, the inner part of the cement core was impermeable during the duration of the experiment. The preferential flow path can be described as a highly permeable and highly porous area with an aperture of about 5 mu m and a permeability of 3 . 10(-12) m(2) (3 Darcy). It follows that the fluid flow characteristics of a cemented area inside a borehole cannot be described using one permeability value for the entire cement-steel composite. Furthermore, it can be concluded that the quality of the cement and the filling process regarding the cement-steel interface is crucial to minimize possible well leakages.},
  language  = {en}
}
@article{KocNathoThieken2021,
  author    = {Ko{\c{c}}, Gamze and Natho, Stephanie and Thieken, Annegret},
  title     = {Estimating direct economic impacts of severe flood events in Turkey (2015-2020)},
  series = {International journal of disaster risk reduction : IJDRR},
  volume    = {58},
  journal   = {International journal of disaster risk reduction : IJDRR},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2212-4209},
  doi       = {10.1016/j.ijdrr.2021.102222},
  pages     = {16},
  year      = {2021},
  abstract  = {Over the past decades, floods have caused significant financial losses in Turkey, amounting to US\$ 800 million between 1960 and 2014. With the Sendai Framework for Disaster Risk Reduction 2015-2030 (SFDRR), it is aimed to reduce the direct economic loss from disasters in relation to the global gross domestic product (GDP) by 2030. Accordingly, a methodology based on experiences from developing countries was proposed by the United Nations Office for Disaster Risk Reduction (UNDRR) to estimate direct economic losses on the macro-scale. Since Turkey also signed the SFDRR, we aimed to adapt, validate and apply the loss estimation model proposed by the UNDRR in Turkey for the first time. To do so, the well-documented flood event in Mersin of 2016 was used to calibrate the damage ratios for the agricultural, commercial and residential sectors, as well as educational facilities. Case studies between 2015 and 2020 with documented losses were further used to validate the model. Finally, model applications provided initial loss estimates for floods occurred recently in Turkey. Despite the limited event documentation for each sector, the calibrated model yielded good results when compared to documented losses. Thus, by implementing the UNDRR method, this study provides an approach to estimate the direct economic losses in Turkey on the macro-scale, which can be used to fill gaps in event databases, support the coordination of financial aid after flood events and facilitate monitoring of the progress toward and achievement of Global Target C of the Sendai Framework for Disaster Risk Reduction 2015-2030.},
  language  = {en}
}
@phdthesis{Senftleben2020,
  author    = {Senftleben, Robin},
  title     = {Earth's magnetic field over the last 1000 years},
  doi       = {10.25932/publishup-47315},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473150},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xii, 104},
  year      = {2020},
  abstract  = {To investigate the reliability and stability of spherical harmonic models based on archeo/-paleomagnetic data, 2000 Geomagnetic models were calculated. All models are based on the same data set but with randomized uncertainties. Comparison of these models to the geomagnetic field model gufm1 showed that large scale magnetic field structures up to spherical harmonic degree 4 are stable throughout all models. Through a ranking of all models by comparing the dipole coefficients to gufm1 more realistic uncertainty estimates were derived than the authors of the data provide. The derived uncertainty estimates were used in further modelling, which combines archeo/-paleomagnetic and historical data. The huge difference in data count, accuracy and coverage of these two very different data sources made it necessary to introduce a time dependent spatial damping, which was constructed to constrain the spatial complexity of the model. Finally 501 models were calculated by considering that each data point is a Gaussian random variable, whose mean is the original value and whose standard deviation is its uncertainty. The final model arhimag1k is calculated by taking the mean of the 501 sets of Gauss coefficients. arhimag1k fits different dependent and independent data sets well. It shows an early reverse flux patch at the core-mantle boundary between 1000 AD and 1200 AD at the location of the South Atlantic Anomaly today. Another interesting feature is a high latitude flux patch over Greenland between 1200 and 1400 AD. The dipole moment shows a constant behaviour between 1600 and 1840 AD. In the second part of the thesis 4 new paleointensities from 4 different flows of the island Fogo, which is part of Cape Verde, are presented. The data is fitted well by arhimag1k with the exception of the value at 1663 of 28.3 microtesla, which is approximately 10 microtesla lower than the model suggest.},
  language  = {en}
}
@phdthesis{Baeckemo2022,
  author    = {B{\"a}ckemo, Johan Dag Valentin},
  title     = {Digital tools and bioinspiration for the implementation in science and medicine},
  doi       = {10.25932/publishup-57145},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-571458},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xiv, 108},
  year      = {2022},
  abstract  = {Diese Doktorarbeit untersucht anhand dreier Beispiele, wie digitale Werkzeuge wie Programmierung, Modellierung, 3D-Konstruktions-Werkzeuge und additive Fertigung in Verbindung mit einer auf Biomimetik basierenden Design\-strategie zu neuen Analysemethoden und Produkten f{\"u}hren k{\"o}nnen, die in Wissenschaft und Medizin Anwendung finden. Das Verfahren der Funkenerosion (EDM) wird h{\"a}ufig angewandt, um harte Metalle zu verformen oder zu formen, die mit normalen Maschinen nur schwer zu bearbeiten sind. In dieser Arbeit wird eine neuartige Kr{\"u}mmungsanalysemethode als Alternative zur Rauheitsanalyse vorgestellt. Um besser zu verstehen, wie sich die Oberfl{\"a}che w{\"a}hrend der Bearbeitungszeit des EDM-Prozesses ver{\"a}ndert, wurde außerdem ein digitales Schlagmodell erstellt, das auf einem urspr{\"u}nglich flachen Substrat Krater auf Erhebungen erzeugte. Es wurde festgestellt, dass ein Substrat bei etwa 10.000 St{\"o}ßen ein Gleichgewicht erreicht. Die vorgeschlagene Kr{\"u}mmungsanalysemethode hat das Potenzial, bei der Entwicklung neuer Zellkultursubstrate f{\"u}r die Stammzellenforschung eingesetzt zu werden. Zwei Arten, die in dieser Arbeit aufgrund ihrer interessanten Mechanismen analysiert wurden, sind die Venusfliegenfalle und der Bandwurm. Die Venusfliegenfalle kann ihr Maul mit einer erstaunlichen Geschwindigkeit schließen. Der Schließmechanismus kann f{\"u}r die Wissenschaft interessant sein und ist ein Beispiel f{\"u}r ein so genanntes mechanisch bi-stabiles System - es gibt zwei stabile Zust{\"a}nde. Der Bandwurm ist bei S{\"a}ugetieren meist im unteren Darm zu finden und heftet sich mit seinen Saugn{\"a}pfen an die Darmw{\"a}nde. Wenn der Bandwurm eine geeignete Stelle gefunden hat, st{\"o}ßt er seine Haken aus und heftet sich dauerhaft an die Wand. Diese Funktion k{\"o}nnte in der minimalinvasiven Medizin genutzt werden, um eine bessere Kontrolle der Implantate w{\"a}hrend des Implantationsprozesses zu erm{\"o}glichen. F{\"u}r beide Projekte wurde ein mathematisches Modell, das so genannte Chained Beam Constraint Model (CBCM), verwendet, um das nichtlineare Biegeverhalten zu modellieren und somit vorherzusagen, welche Strukturen ein mechanisch bi-stabiles Verhalten aufweisen k{\"o}nnten. Daraufhin konnten zwei Prototypen mit einem 3D-Drucker gedruckt und durch Experimente veranschaulicht werden, dass sie beide ein bi-stabiles Verhalten aufweisen. Diese Arbeit verdeutlicht das hohe Anwendungspotenzial f{\"u}r neue Analysenmethoden in der Wissenschaft und f{\"u}r neue Medizinprodukte in der minimalinvasiven Medizin.},
  language  = {en}
}
@article{MarschallSkorovZakharovetal.2020,
  author    = {Marschall, Raphael and Skorov, Yuri and Zakharov, Vladimir and Rezac, Ladislav and Gerig, Selina-Barbara and Christou, Chariton and Dadzie, S. Kokou and Migliorini, Alessandra and Rinaldi, Giovanna and Agarwal, Jessica and Vincent, Jean-Baptiste and Kappel, David},
  title     = {Cometary comae-surface links the physics of gas and dust from the surface to a spacecraft},
  series = {Space science reviews},
  volume    = {216},
  journal   = {Space science reviews},
  number    = {8},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {0038-6308},
  doi       = {10.1007/s11214-020-00744-0},
  pages     = {53},
  year      = {2020},
  abstract  = {A comet is a highly dynamic object, undergoing a permanent state of change. These changes have to be carefully classified and considered according to their intrinsic temporal and spatial scales. The Rosetta mission has, through its contiguous in-situ and remote sensing coverage of comet 67P/Churyumov-Gerasimenko (hereafter 67P) over the time span of August 2014 to September 2016, monitored the emergence, culmination, and winding down of the gas and dust comae. This provided an unprecedented data set and has spurred a large effort to connect in-situ and remote sensing measurements to the surface. In this review, we address our current understanding of cometary activity and the challenges involved when linking comae data to the surface. We give the current state of research by describing what we know about the physical processes involved from the surface to a few tens of kilometres above it with respect to the gas and dust emission from cometary nuclei. Further, we describe how complex multidimensional cometary gas and dust models have developed from the Halley encounter of 1986 to today. This includes the study of inhomogeneous outgassing and determination of the gas and dust production rates. Additionally, the different approaches used and results obtained to link coma data to the surface will be discussed. We discuss forward and inversion models and we describe the limitations of the respective approaches. The current literature suggests that there does not seem to be a single uniform process behind cometary activity. Rather, activity seems to be the consequence of a variety of erosion processes, including the sublimation of both water ice and more volatile material, but possibly also more exotic processes such as fracture and cliff erosion under thermal and mechanical stress, sub-surface heat storage, and a complex interplay of these processes. Seasons and the nucleus shape are key factors for the distribution and temporal evolution of activity and imply that the heliocentric evolution of activity can be highly individual for every comet, and generalisations can be misleading.},
  language  = {en}
}
@phdthesis{Reusser2011,
  author    = {Reusser, Dominik Edwin},
  title     = {Combining smart model diagnostics and effective data collection for snow catchments},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-52574},
  school      = {Universit{\"a}t Potsdam},
  year      = {2011},
  abstract  = {Complete protection against flood risks by structural measures is impossible. Therefore flood prediction is important for flood risk management. Good explanatory power of flood models requires a meaningful representation of bio-physical processes. Therefore great interest exists to improve the process representation. Progress in hydrological process understanding is achieved through a learning cycle including critical assessment of an existing model for a given catchment as a first step. The assessment will highlight deficiencies of the model, from which useful additional data requirements are derived, giving a guideline for new measurements. These new measurements may in turn lead to improved process concepts. The improved process concepts are finally summarized in an updated hydrological model. In this thesis I demonstrate such a learning cycle, focusing on the advancement of model evaluation methods and more cost effective measurements. For a successful model evaluation, I propose that three questions should be answered: 1) when is a model reproducing observations in a satisfactory way? 2) If model results deviate, of what nature is the difference? And 3) what are most likely the relevant model components affecting these differences? To answer the first two questions, I developed a new method to assess the temporal dynamics of model performance (or TIGER - TIme series of Grouped Errors). This method is powerful in highlighting recurrent patterns of insufficient model behaviour for long simulation periods. I answered the third question with the analysis of the temporal dynamics of parameter sensitivity (TEDPAS). For calculating TEDPAS, an efficient method for sensitivity analysis is necessary. I used such an efficient method called Fourier Amplitude Sensitivity Test, which has a smart sampling scheme. Combining the two methods TIGER and TEDPAS provided a powerful tool for model assessment. With WaSiM-ETH applied to the Weisseritz catchment as a case study, I found insufficient process descriptions for the snow dynamics and for the recession during dry periods in late summer and fall. Focusing on snow dynamics, reasons for poor model performance can either be a poor representation of snow processes in the model, or poor data on snow cover, or both. To obtain an improved data set on snow cover, time series of snow height and temperatures were collected with a cost efficient method based on temperature measurements on multiple levels at each location. An algorithm was developed to simultaneously estimate snow height and cold content from these measurements. Both, snow height and cold content are relevant quantities for spring flood forecasting. Spatial variability was observed at the local and the catchment scale with an adjusted sampling design. At the local scale, samples were collected on two perpendicular transects of 60 m length and analysed with geostatistical methods. The range determined from fitted theoretical variograms was within the range of the sampling design for 80\% of the plots. No patterns were found, that would explain the random variability and spatial correlation at the local scale. At the watershed scale, locations of the extensive field campaign were selected according to a stratified sample design to capture the combined effects of elevation, aspect and land use. The snow height is mainly affected by the plot elevation. The expected influence of aspect and land use was not observed. To better understand the deficiencies of the snow module in WaSiM-ETH, the same approach, a simple degree day model was checked for its capability to reproduce the data. The degree day model was capable to explain the temporal variability for plots with a continuous snow pack over the entire snow season, if parameters were estimated for single plots. However, processes described in the simple model are not sufficient to represent multiple accumulation-melt-cycles, as observed for the lower catchment. Thus, the combined spatio-temporal variability at the watershed scale is not captured by the model. Further tests on improved concepts for the representation of snow dynamics at the Weißeritz are required. From the data I suggest to include at least rain on snow and redistribution by wind as additional processes to better describe spatio-temporal variability. Alternatively an energy balance snow model could be tested. Overall, the proposed learning cycle is a useful framework for targeted model improvement. The advanced model diagnostics is valuable to identify model deficiencies and to guide field measurements. The additional data collected throughout this work helps to get a deepened understanding of the processes in the Weisseritz catchment.},
  language  = {en}
}
@phdthesis{Huber2010,
  author    = {Huber, Veronika Emilie Charlotte},
  title     = {Climate impact on phytoplankton blooms in shallow lakes},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42346},
  school      = {Universit{\"a}t Potsdam},
  year      = {2010},
  abstract  = {Lake ecosystems across the globe have responded to climate warming of recent decades. However, correctly attributing observed changes to altered climatic conditions is complicated by multiple anthropogenic influences on lakes. This thesis contributes to a better understanding of climate impacts on freshwater phytoplankton, which forms the basis of the food chain and decisively influences water quality. The analyses were, for the most part, based on a long-term data set of physical, chemical and biological variables of a shallow, polymictic lake in north-eastern Germany (M{\"u}ggelsee), which was subject to a simultaneous change in climate and trophic state during the past three decades. Data analysis included constructing a dynamic simulation model, implementing a genetic algorithm to parameterize models, and applying statistical techniques of classification tree and time-series analysis. Model results indicated that climatic factors and trophic state interactively determine the timing of the phytoplankton spring bloom (phenology) in shallow lakes. Under equally mild spring conditions, the phytoplankton spring bloom collapsed earlier under high than under low nutrient availability, due to a switch from a bottom-up driven to a top-down driven collapse. A novel approach to model phenology proved useful to assess the timings of population peaks in an artificially forced zooplankton-phytoplankton system. Mimicking climate warming by lengthening the growing period advanced algal blooms and consequently also peaks in zooplankton abundance. Investigating the reasons for the contrasting development of cyanobacteria during two recent summer heat wave events revealed that anomalously hot weather did not always, as often hypothesized, promote cyanobacteria in the nutrient-rich lake studied. The seasonal timing and duration of heat waves determined whether critical thresholds of thermal stratification, decisive for cyanobacterial bloom formation, were crossed. In addition, the temporal patterns of heat wave events influenced the summer abundance of some zooplankton species, which as predators may serve as a buffer by suppressing phytoplankton bloom formation. This thesis adds to the growing body of evidence that lake ecosystems have strongly responded to climatic changes of recent decades. It reaches beyond many previous studies of climate impacts on lakes by focusing on underlying mechanisms and explicitly considering multiple environmental changes. Key findings show that climate impacts are more severe in nutrient-rich than in nutrient-poor lakes. Hence, to develop lake management plans for the future, limnologists need to seek a comprehensive, mechanistic understanding of overlapping effects of the multi-faceted human footprint on aquatic ecosystems.},
  language  = {en}
}
@article{BecherGrimmThorbeketal.2014,
  author    = {Becher, Matthias A. and Grimm, Volker and Thorbek, Pernille and Horn, Juliane and Kennedy, Peter J. and Osborne, Juliet L.},
  title     = {BEEHAVE: a systems model of honeybee colony dynamics and foraging to explore multifactorial causes of colony failure},
  series = {Journal of applied ecology : an official journal of the British Ecological Society},
  volume    = {51},
  journal   = {Journal of applied ecology : an official journal of the British Ecological Society},
  number    = {2},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0021-8901},
  doi       = {10.1111/1365-2664.12222},
  pages     = {470 -- 482},
  year      = {2014},
  abstract  = {BEEHAVE offers a valuable tool for researchers to design and focus field experiments, for regulators to explore the relative importance of stressors to devise management and policy advice and for beekeepers to understand and predict varroa dynamics and effects of management interventions. We expect that scientists and stakeholders will find a variety of applications for BEEHAVE, stimulating further model development and the possible inclusion of other stressors of potential importance to honeybee colony dynamics.},
  language  = {en}
}
@article{RolphOverduinRavensetal.2022,
  author    = {Rolph, Rebecca and Overduin, Pier Paul and Ravens, Thomas and Lantuit, Hugues and Langer, Moritz},
  title     = {ArcticBeach v1.0},
  series = {Frontiers in Earth Science},
  volume    = {10},
  journal   = {Frontiers in Earth Science},
  publisher = {Frontiers Media},
  address   = {Lausanne},
  issn      = {2296-6463},
  doi       = {10.3389/feart.2022.962208},
  pages     = {19},
  year      = {2022},
  abstract  = {In the Arctic, air temperatures are increasing and sea ice is declining, resulting in larger waves and a longer open water season, all of which intensify the thaw and erosion of ice-rich coasts. Climate change has been shown to increase the rate of Arctic coastal erosion, causing problems for Arctic cultural heritage, existing industrial, military, and civil infrastructure, as well as changes in nearshore biogeochemistry. Numerical models that reproduce historical and project future Arctic erosion rates are necessary to understand how further climate change will affect these problems, and no such model yet exists to simulate the physics of erosion on a pan-Arctic scale. We have coupled a bathystrophic storm surge model to a simplified physical erosion model of a permafrost coastline. This Arctic erosion model, called ArcticBeach v1.0, is a first step toward a physical parameterization of Arctic shoreline erosion for larger-scale models. It is forced by wind speed and direction, wave period and height, sea surface temperature, all of which are masked during times of sea ice cover near the coastline. Model tuning requires observed historical retreat rates (at least one value), as well as rough nearshore bathymetry. These parameters are already available on a pan-Arctic scale. The model is validated at three study sites at 1) Drew Point (DP), Alaska, 2) Mamontovy Khayata (MK), Siberia, and 3) Veslebogen Cliffs, Svalbard. Simulated cumulative retreat rates for DP and MK respectively (169 and 170 m) over the time periods studied at each site (2007-2016, and 1995-2018) are found to the same order of magnitude as observed cumulative retreat (172 and 120 m). The rocky Veslebogen cliffs have small observed cumulative retreat rates (0.05 m over 2014-2016), and our model was also able to reproduce this same order of magnitude of retreat (0.08 m). Given the large differences in geomorphology between the study sites, this study provides a proof-of-concept that ArcticBeach v1.0 can be applied on very different permafrost coastlines. ArcticBeach v1.0 provides a promising starting point to project retreat of Arctic shorelines, or to evaluate historical retreat in places that have had few observations.},
  language  = {en}
}
@phdthesis{Becker2013,
  author    = {Becker, Basil},
  title     = {Architectural modelling and verification of open service-oriented systems of systems},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70158},
  school      = {Universit{\"a}t Potsdam},
  year      = {2013},
  abstract  = {Systems of Systems (SoS) have received a lot of attention recently. In this thesis we will focus on SoS that are built atop the techniques of Service-Oriented Architectures and thus combine the benefits and challenges of both paradigms. For this thesis we will understand SoS as ensembles of single autonomous systems that are integrated to a larger system, the SoS. The interesting fact about these systems is that the previously isolated systems are still maintained, improved and developed on their own. Structural dynamics is an issue in SoS, as at every point in time systems can join and leave the ensemble. This and the fact that the cooperation among the constituent systems is not necessarily observable means that we will consider these systems as open systems. Of course, the system has a clear boundary at each point in time, but this can only be identified by halting the complete SoS. However, halting a system of that size is practically impossible. Often SoS are combinations of software systems and physical systems. Hence a failure in the software system can have a serious physical impact what makes an SoS of this kind easily a safety-critical system. The contribution of this thesis is a modelling approach that extends OMG's SoaML and basically relies on collaborations and roles as an abstraction layer above the components. This will allow us to describe SoS at an architectural level. We will also give a formal semantics for our modelling approach which employs hybrid graph-transformation systems. The modelling approach is accompanied by a modular verification scheme that will be able to cope with the complexity constraints implied by the SoS' structural dynamics and size. Building such autonomous systems as SoS without evolution at the architectural level --- i. e. adding and removing of components and services --- is inadequate. Therefore our approach directly supports the modelling and verification of evolution.},
  language  = {en}
}