@article{RauschBrockmeyerSchwerdtle2021,
  author    = {Rausch, Ann-Kristin and Brockmeyer, Robert and Schwerdtle, Tanja},
  title     = {Development and validation of a liquid chromatography tandem mass spectrometry multi-method for the determination of 41 free and modified mycotoxins in beer},
  series = {Food chemistry},
  volume    = {338},
  journal   = {Food chemistry},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {1873-7072},
  doi       = {10.1016/j.foodchem.2020.127801},
  year      = {2021},
  abstract  = {A fast high performance liquid chromatography tandem mass spectrometry multi-method based on an ACN-precipitation extraction was developed for the analysis of 41 (modified) mycotoxins in beer. Validation according to the performance criteria defined by the European Commission (EC) in Commission Decision no. 657/2002 revealed good linearity (R2 > 0.99), repeatability (RSDr < 15\%), reproducibility (RSDR < 15\%), and recovery (79-100\%). Limits of quantification ranging from 0.04 to 75 µg/L were obtained. Matrix effects varied from -67 to +319\% and were compensated for using standard addition. In total, 87 beer samples, produced worldwide, were analyzed for the presence of mycotoxins with a focus on modified mycotoxins, whereof 76\% of the samples were contaminated with at least one mycotoxin. The most prevalent mycotoxins were deoxynivalenol-3-glucoside (63\%), HT-2 toxin (15\%), and tenuazonic acid (13\%). Exposure estimates of deoxynivalenol and its metabolites for German beer revealed no significant contribution to intake of deoxynivalenol.},
  language  = {en}
}