@article{PetrovićWendler2021, author = {Petrović, Saša and Wendler, Petra}, title = {A RADD approach to probing AAA plus protein function}, series = {Nature structural \& molecular biology}, volume = {28}, journal = {Nature structural \& molecular biology}, number = {4}, publisher = {Nature Publishing Group}, address = {Berlin}, issn = {1545-9993}, doi = {10.1038/s41594-021-00579-5}, pages = {329 -- 330}, year = {2021}, abstract = {AAA+ proteins (ATPases associated with various cellular activities) catalyze the energy-dependent movement or rearrangement of macromolecules. A new study addresses the important question of how to design a selective chemical inhibitor for specific proteins in this diverse superfamily. The powerful chemical genetics approach adds to a growing toolbox of applications that allow dissection of the functions of distinct AAA+ proteins in vivo, facilitating the first steps toward effective drug development.}, language = {en} }