@article{GuoSchwitallaBenndorfetal.2020,
  author    = {Guo, Huijuan and Schwitalla, Jan W. and Benndorf, Ren{\´e} and Baunach, Martin and Steinbeck, Christoph and G{\"o}rls, Helmar and de Beer, Z. Wilhelm and Regestein, Lars and Beemelmanns, Christine},
  title     = {Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols},
  series = {Organic letters},
  volume    = {22},
  journal   = {Organic letters},
  number    = {7},
  publisher = {American Chemical Society},
  address   = {Washington, DC},
  issn      = {1523-7060},
  doi       = {10.1021/acs.orglett.0c00601},
  pages     = {2634 -- 2638},
  year      = {2020},
  abstract  = {Growth from spores activated a biosynthetic gene cluster in Actinomadura sp. RB29, resulting in the identification of two novel groups of halogenated polyketide natural products, named maduralactomycins and actinospirols. The unique tetracyclic and spirocyclic structures were assigned based on a combination of NMR analysis, chemoinformatic calculations, X-ray crystallography, and C-13 labeling studies. On the basis of HRMS2 data, genome mining, and gene expression studies, we propose an underlying noncanonical angucycline biosynthesis and extensive post-polyketide synthase (PKS) oxidative modifications.},
  language  = {en}
}