@article{KoelmanPivovarovaRamichPfeifferetal.2019,
  author    = {Koelman, Liselot A. and Pivovarova-Ramich, Olga and Pfeiffer, Andreas F. H. and Grune, Tilman and Aleksandrova, Krasimira},
  title     = {Cytokines for evaluation of chronic inflammatory status in ageing research},
  series = {Immunity \& Ageing},
  volume    = {16},
  journal   = {Immunity \& Ageing},
  publisher = {BMC},
  address   = {London},
  issn      = {1742-4933},
  doi       = {10.1186/s12979-019-0151-1},
  pages     = {12},
  year      = {2019},
  abstract  = {Background: There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers of inflammageing; however, their measurement in human samples has been challenging. This study aimed to assess the reliability of a pro- and anti-inflammatory cytokine panel in a sample of healthy people measured with a novel electrochemiluminescent multiplex immunoassay platform (Meso Scale Discovery, MSD), and to characterize their associations with metabolic and inflammatory phenotypes.},
  language  = {en}
}
@article{SchenkEichelmannSchulzeetal.2019,
  author    = {Schenk, Matthew and Eichelmann, Fabian and Schulze, Matthias Bernd and Rudovich, Natalia and Pfeiffer, Andreas F. H. and di Giuseppe, Romina and B{\"o}ing, Heiner and Aleksandrova, Krasimira},
  title     = {Reproducibility of novel immune-inflammatory biomarkers over 4 months},
  series = {Biomarkers in medicine},
  volume    = {13},
  journal   = {Biomarkers in medicine},
  number    = {8},
  publisher = {Future Medicine},
  address   = {London},
  issn      = {1752-0363},
  doi       = {10.2217/bmm-2018-0351},
  pages     = {639 -- 648},
  year      = {2019},
  abstract  = {Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95\% CIs) ranged from good for TGF-beta (0.75 [95\% CI: 0.33-0.90]) to excellent for MMF (0.81 [95\% CI: 0.64-0.90]), clusterin (0.83 [95\% CI: 0.78-0.87]) and suPAR (0.91 [95\% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.},
  language  = {en}
}