@inproceedings{HaferKiy2013, author = {Hafer, J{\"o}rg and Kiy, Alexander}, title = {The university-wide introduction of an ePortfolio system as transdisciplinary task}, series = {Proceedings of the PLE Conference 2013: Learning and Diversity in the Cities of the Future}, booktitle = {Proceedings of the PLE Conference 2013: Learning and Diversity in the Cities of the Future}, editor = {Buchem, Ilona and Graham, Attwell and Tur, Gemma}, publisher = {Logos}, address = {Berlin}, pages = {363 -- 373}, year = {2013}, language = {en} } @inproceedings{AnderssonKeuneckeEseretal.2014, author = {Andersson, H. and Keunecke, A. and Eser, A. and Huisinga, Wilhelm and Reinisch, W. and Kloft, Charlotte}, title = {Pharmacokinetic considerations for optimising dosing regimens of a potsdam univ infliximab in patients with Crohn's disease}, series = {JOURNAL OF CROHNS \& COLITIS}, volume = {8}, booktitle = {JOURNAL OF CROHNS \& COLITIS}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1873-9946}, doi = {10.1016/S1873-9946(14)60086-6}, pages = {S44 -- S44}, year = {2014}, language = {en} } @inproceedings{SteenholdtEdlundAinsworthetal.2015, author = {Steenholdt, Casper and Edlund, Helena and Ainsworth, Mark A. and Brynskov, Jorn and Thomsen, Ole Ostergaard and Huisinga, Wilhelm and Kloft, Charlotte}, title = {Relationship between measures of infliximab exposure and clinical outcome of infliximab intensification at therapeutic failure in Crohn's disease}, series = {JOURNAL OF CROHNS \& COLITIS}, volume = {9}, booktitle = {JOURNAL OF CROHNS \& COLITIS}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1873-9946}, pages = {S330 -- S330}, year = {2015}, language = {en} } @inproceedings{AudinDucourtiouxOuedraogoetal.2017, author = {Audin, Mich{\`e}le and Ducourtioux, Catherine and Ou{\´e}draogo, Fran{\c{c}}oise and Schulz, Ren{\´e} and Delgado, Julio and Ruzhansky, Michael and Lebeau, Gilles}, title = {Integral Fourier operators}, editor = {Paycha, Sylvie}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-413-5}, issn = {2199-4951}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-402657}, pages = {xxi, 229}, year = {2017}, abstract = {This volume of contributions based on lectures delivered at a school on Fourier Integral Operators held in Ouagadougou, Burkina Faso, 14-26 September 2015, provides an introduction to Fourier Integral Operators (FIO) for a readership of Master and PhD students as well as any interested layperson. Considering the wide spectrum of their applications and the richness of the mathematical tools they involve, FIOs lie the cross-road of many a field. This volume offers the necessary background, whether analytic or geometric, to get acquainted with FIOs, complemented by more advanced material presenting various aspects of active research in that area.}, language = {en} } @inproceedings{VallerianiRoellyKulik2017, author = {Valleriani, Angelo and Roelly, Sylvie and Kulik, Alexei Michajlovič}, title = {Stochastic processes with applications in the natural sciences}, series = {Lectures in pure and applied mathematics}, booktitle = {Lectures in pure and applied mathematics}, number = {4}, editor = {Roelly, Sylvie and H{\"o}gele, Michael and Rafler, Mathias}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-414-2}, issn = {2199-4951}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-401802}, pages = {ix, 124}, year = {2017}, abstract = {The interdisciplinary workshop STOCHASTIC PROCESSES WITH APPLICATIONS IN THE NATURAL SCIENCES was held in Bogot{\´a}, at Universidad de los Andes from December 5 to December 9, 2016. It brought together researchers from Colombia, Germany, France, Italy, Ukraine, who communicated recent progress in the mathematical research related to stochastic processes with application in biophysics. The present volume collects three of the four courses held at this meeting by Angelo Valleriani, Sylvie Rœlly and Alexei Kulik. A particular aim of this collection is to inspire young scientists in setting up research goals within the wide scope of fields represented in this volume. Angelo Valleriani, PhD in high energy physics, is group leader of the team "Stochastic processes in complex and biological systems" from the Max-Planck-Institute of Colloids and Interfaces, Potsdam. Sylvie Rœlly, Docteur en Math{\´e}matiques, is the head of the chair of Probability at the University of Potsdam. Alexei Kulik, Doctor of Sciences, is a Leading researcher at the Institute of Mathematics of Ukrainian National Academy of Sciences.}, language = {en} } @inproceedings{RungrottheeraChangSchulze2020, author = {Rungrottheera, Wannarut and Chang, Der-Chen and Schulze, Bert-Wolfgang}, title = {The edge calculus of singularity order >3}, series = {Journal of nonlinear and convex analysis : an international journal}, volume = {21}, booktitle = {Journal of nonlinear and convex analysis : an international journal}, number = {2}, publisher = {Yokohama Publishers}, address = {Yokohama}, issn = {1345-4773}, pages = {387 -- 401}, year = {2020}, abstract = {We study Mellin pseudo-differential algebras on singular straight cones and manifolds with singularity of order >= 3. Those are necessary to express parametrices of elliptic differential operators with a corresponding cornerdegenerate behavior, and we obtain regularity in weighted spaces.}, language = {en} } @inproceedings{DemarisGrišićHuisingaetal.2020, author = {D{\´e}maris, Alise and Grišić, Ana-Marija and Huisinga, Wilhelm and Walter, Reinisch and Kloft, Charlotte}, title = {Evaluation of dosing strategies of anti-TNF alpha monoclonal antibodies using pharmacokinetic modelling and simulation}, series = {Journal of Crohn's and Colitis}, volume = {14}, booktitle = {Journal of Crohn's and Colitis}, number = {Supp. 1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1873-9946}, doi = {10.1093/ecco-jcc/jjz203.201}, pages = {S171 -- S172}, year = {2020}, abstract = {Background: Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn's disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed. Methods: A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration-time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy. Results: For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110\% and CV ≈80\%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15\%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52-71\%), being the highest for LBW-adjusted dosing. Conclusion: By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66\% vs. 71\%, respectively).}, language = {en} }