@article{VallerianiZhangNagaretal.2011, author = {Valleriani, Angelo and Zhang, Gong and Nagar, Apoorva and Ignatova, Zoya and Lipowsky, Reinhard}, title = {Length-dependent translation of messenger RNA by ribosomes}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {83}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {4}, publisher = {American Physical Society}, address = {College Park}, issn = {1539-3755}, doi = {10.1103/PhysRevE.83.042903}, pages = {4}, year = {2011}, abstract = {A simple measure for the efficiency of protein synthesis by ribosomes is provided by the steady state amount of protein per messenger RNA (mRNA), the so-called translational ratio, which is proportional to the translation rate. Taking the degradation of mRNA into account, we show theoretically that both the translation rate and the translational ratio decrease with increasing mRNA length, in agreement with available experimental data for the prokaryote Escherichia coli. We also show that, compared to prokaryotes, mRNA degradation in eukaryotes leads to a less rapid decrease of the translational ratio. This finding is consistent with the fact that, compared to prokaryotes, eukaryotes tend to have longer proteins.}, language = {en} } @inproceedings{MiettinenMonticelliNedumpullyGovindanetal.2015, author = {Miettinen, Markus S. and Monticelli, Luca and Nedumpully-Govindan, Praveen and Knecht, Volker and Ignatova, Zoya}, title = {Initiating polyglutamine aggregation - computational clarification of the structural details}, series = {Biophysical journal}, volume = {108}, booktitle = {Biophysical journal}, number = {2}, publisher = {Cell Press}, address = {Cambridge}, issn = {0006-3495}, pages = {386A -- 386A}, year = {2015}, language = {en} }