@book{OPUS4-64626, title = {Allegory and the Poetic Self}, editor = {Palmer, Barton R. and Philipowski, Katharina and R{\"u}themann, Julia}, publisher = {University Press of Florida}, address = {Gainesville}, isbn = {978-0-81306-751-3}, doi = {10.5744/florida/9780813069517.001.0001}, url = {http://nbn-resolving.de/https://ebookcentral.proquest.com/lib/potsdamuni/reader.action?docID=30189190}, pages = {316}, year = {2022}, abstract = {This book is the first collective examination of Late Medieval intimate first-person narratives that blurred the lines between author, narrator, and protagonist and usually feature personification allegory and courtly love tropes, creating an experimental new family of poetry. In this volume, contributors analyze why the allegorical first-person romance embedded itself in the vernacular literature of Western Europe and remained popular for more than two centuries. The editors identify and discuss three predominant forms within this family: debate poetry, dream allegories, and autobiographies. Contributors offer textual analyses of key works from late medieval German, French, Italian, and Iberian literature, with discussion of developments in England, as well. Allegory and the Poetic Self offers a sophisticated, theoretically current discussion of relevant literature. This exploration of medieval "I" narratives offers insights not just into the premodern period but also into Western literature's subsequent traditions of self-analysis and identity crafting through storytelling.}, language = {en} } @inproceedings{MirbabaieRieskampHofeditzetal.2024, author = {Mirbabaie, Milad and Rieskamp, Jonas and Hofeditz, Lennart and Stieglitz, Stefan}, title = {Breaking down barriers}, series = {Proceedings of the 57th Annual Hawaii International Conference on System Sciences}, booktitle = {Proceedings of the 57th Annual Hawaii International Conference on System Sciences}, editor = {Bui, Tung X.}, publisher = {Department of IT Management Shidler College of Business University of Hawaii}, address = {Honolulu, HI}, isbn = {978-0-99813-317-1}, pages = {672 -- 681}, year = {2024}, abstract = {Many researchers hesitate to provide full access to their datasets due to a lack of knowledge about research data management (RDM) tools and perceived fears, such as losing the value of one's own data. Existing tools and approaches often do not take into account these fears and missing knowledge. In this study, we examined how conversational agents (CAs) can provide a natural way of guidance through RDM processes and nudge researchers towards more data sharing. This work offers an online experiment in which researchers interacted with a CA on a self-developed RDM platform and a survey on participants' data sharing behavior. Our findings indicate that the presence of a guiding and enlightening CA on an RDM platform has a constructive influence on both the intention to share data and the actual behavior of data sharing. Notably, individual factors do not appear to impede or hinder this effect.}, language = {en} } @article{DuttaJonssonVasyuraBathke2021, author = {Dutta, Rishabh and J{\´o}nsson, Sigurj{\´o}n and Vasyura-Bathke, Hannes}, title = {Simultaneous Bayesian estimation of non-planar fault geometry and spatially-variable slip}, series = {JGR / AGU, American Geophysical Union : Solid earth}, volume = {126}, journal = {JGR / AGU, American Geophysical Union : Solid earth}, number = {7}, publisher = {Wiley}, address = {Hoboken, NJ}, issn = {2169-9313}, doi = {10.1029/2020JB020441}, pages = {28}, year = {2021}, abstract = {Large earthquakes are usually modeled with simple planar fault surfaces or a combination of several planar fault segments. However, in general, earthquakes occur on faults that are non-planar and exhibit significant geometrical variations in both the along-strike and down-dip directions at all spatial scales. Mapping of surface fault ruptures and high-resolution geodetic observations are increasingly revealing complex fault geometries near the surface and accurate locations of aftershocks often indicate geometrical complexities at depth. With better geodetic data and observations of fault ruptures, more details of complex fault geometries can be estimated resulting in more realistic fault models of large earthquakes. To address this topic, we here parametrize non-planar fault geometries with a set of polynomial parameters that allow for both along-strike and down-dip variations in the fault geometry. Our methodology uses Bayesian inference to estimate the non-planar fault parameters from geodetic data, yielding an ensemble of plausible models that characterize the uncertainties of the non-planar fault geometry and the fault slip. The method is demonstrated using synthetic tests considering slip spatially distributed on a single continuous finite non-planar fault surface with varying dip and strike angles both in the down-dip and along-strike directions. The results show that fault-slip estimations can be biased when a simple planar fault geometry is assumed in presence of significant non-planar geometrical variations. Our method can help to model earthquake fault sources in a more realistic way and may be extended to include multiple non-planar fault segments or other geometrical fault complexities.}, language = {en} } @incollection{PhilipowskiRuethemann2022, author = {Philipowski, Katharina and R{\"u}themann, Julia}, title = {Introduction}, series = {Allegory and the poetic self : first-person narration in late medieval literature}, booktitle = {Allegory and the poetic self : first-person narration in late medieval literature}, publisher = {University Press of Florida}, address = {Gainesville}, isbn = {978-0-81306-751-3}, doi = {10.5744/florida/9780813069517.003.0001}, pages = {1 -- 23}, year = {2022}, abstract = {The introduction addresses the combination of allegory and the first-person narrative form. This combination, which would prove extremely successful as a template in the following decades, seems to have appeared for the first time shortly after 1200. Not long afterward, the Roman de la Rose was the first text to combine the use of the vernacular, the first person, and allegoricity with courtly tropes. This text stands at the beginning of the impressive history of the "family of texts." The introduction provides an overview of the main characteristics of this family and text types belonging to it: debates, dream allegories, and autobiographical texts, by integrating important results of the case studies presented in the volume.}, language = {en} } @inproceedings{MarxBruenkerMirbabaieetal.2024, author = {Marx, Julian and Br{\"u}nker, Felix and Mirbabaie, Milad and Stieglitz, Stefan}, title = {Digital activism on social media}, series = {Proceedings of the 57th Annual Hawaii International Conference on System Sciences}, booktitle = {Proceedings of the 57th Annual Hawaii International Conference on System Sciences}, editor = {Bui, Tung X.}, publisher = {Department of IT Management Shidler College of Business University of Hawaii}, address = {Honolulu, HI}, isbn = {978-0-99813-317-1}, pages = {7205 -- 7214}, year = {2024}, abstract = {Social media constitute an important arena for public debates and steady interchange of issues relevant to society. To boost their reputation, commercial organizations also engage in political, social, or environmental debates on social media. To engage in this type of digital activism, organizations increasingly utilize the social media profiles of executive employees and other brand ambassadors. However, the relationship between brand ambassadors' digital activism and corporate reputation is only vaguely understood. The results of a qualitative inquiry suggest that digital activism via brand ambassadors can be risky (e.g., creating additional surface for firestorms, financial loss) and rewarding (e.g., emitting authenticity, employing 'megaphones' for industry change) at the same time. The paper informs both scholarship and practitioners about strategic trade-offs that need to be considered when employing brand ambassadors for digital activism.}, language = {en} } @inproceedings{StieglitzFrommKocuretal.2023, author = {Stieglitz, Stefan and Fromm, Jennifer and Kocur, Alexander and Rostalski, Frauke and Duda, Michelle and Evans, Alison and Rieskamp, Jonas and Sievi, Luzia and Pawelec, Maria and Heesen, Jessica and Loh, Wulf and Fuchß, Christoph and Eyilmez, Kaan}, title = {What measures can government institutions in germany take against digital disinformation?}, series = {Wirtschaftsinformatik 2023 Proceedings: track 17}, booktitle = {Wirtschaftsinformatik 2023 Proceedings: track 17}, publisher = {AIS Electronic Library (AISeL)}, address = {[Erscheinungsort nicht ermittelbar]}, pages = {21}, year = {2023}, abstract = {Disinformation campaigns spread rapidly through social media and can cause serious harm, especially in crisis situations, ranging from confusion about how to act to a loss of trust in government institutions. Therefore, the prevention of digital disinformation campaigns represents an important research topic. However, previous research in the field of information systems focused on the technical possibilities to detect and combat disinformation, while ethical and legal perspectives have been neglected so far. In this article, we synthesize previous information systems literature on disinformation prevention measures and discuss these measures from an ethical and legal perspective. We conclude by proposing questions for future research on the prevention of disinformation campaigns from an IS, ethical, and legal perspective. In doing so, we contribute to a balanced discussion on the prevention of digital disinformation campaigns that equally considers technical, ethical, and legal issues, and encourage increased interdisciplinary collaboration in future research.}, language = {en} } @article{FrommStieglitzMirbabaie2024, author = {Fromm, Jennifer and Stieglitz, Stefan and Mirbabaie, Milad}, title = {Virtual reality in digital education}, series = {ACM SIGMIS database}, volume = {55}, journal = {ACM SIGMIS database}, number = {2}, publisher = {ACM}, address = {New York, NY}, issn = {0095-0033}, doi = {10.1145/3663682.3663685}, pages = {14 -- 41}, year = {2024}, abstract = {Virtual reality promises high potential as an immersive, hands-on learning tool for training 21st-century skills. However, previous research revealed that the mere use of digital tools in higher education does not automatically translate into learning outcomes. Instead, information systems studies emphasized the importance of effective use behavior to achieve technology usage goals. Applying the affordance network approach, we investigated what constitutes effective usage behavior regarding a virtual reality collaboration system in digital education. Therefore, we conducted 18 interviews with students and observations of six course sessions. The results uncover how affordance actualization contributed to the achievement of learning goals. A comparison with findings of previous studies on other information systems (i.e., electronic medical record systems, big data analytics, fitness wearables) allowed us to highlight system-specific differences in effective use behavior. We also demonstrated a clear distinction between concepts surrounding effective use theory facilitating the application of the affordance network approach in information systems research.}, language = {en} } @phdthesis{Blaser2024, author = {Blaser, Berenike Lisa}, title = {Premenstrual symptoms as a function of altered central autonomous nervous activity}, doi = {10.25932/publishup-64597}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-645970}, school = {Universit{\"a}t Potsdam}, pages = {XII, 265}, year = {2024}, abstract = {The experience of premenstrual syndrome (PMS) affects up to 90\% of individuals with an active menstrual cycle and involves a spectrum of aversive physiological and psychological symptoms in the days leading up to menstruation (Tschudin et al., 2010). Despite its high prevalence, the precise origins of PMS remain elusive, with influences ranging from hormonal fluctuations to cognitive, social, and cultural factors (Hunter, 2007; Matsumoto et al., 2013). Biologically, hormonal fluctuations, particularly in gonadal steroids, are commonly believed to be implicated in PMS, with the central factor being varying susceptibilities to the fluctuations between individuals and cycles (Rapkin \& Akopians, 2012). Allopregnanolone (ALLO), a neuroactive steroid and progesterone metabolite, has emerged as a potential link to PMS symptoms (Hantsoo \& Epperson, 2020). ALLO is a positive allosteric modulator of the GABAA receptor, influencing inhibitory communication (Rupprecht, 2003; Andr{\´e}en et al., 2006). Different susceptibility to ALLO fluctuations throughout the cycle may lead to reduced GABAergic signal transmission during the luteal phase of the menstrual cycle. The GABAergic system's broad influence leads to a number of affected physiological systems, including a consistent reduction in vagally mediated heart rate variability (vmHRV) during the luteal phase (Schmalenberger et al., 2019). This reduction in vmHRV is more pronounced in individuals with high PMS symptoms (Baker et al., 2008; Matsumoto et al., 2007). Fear conditioning studies have shown inconsistent associations with cycle phases, suggesting a complex interplay between physiological parameters and PMS-related symptoms (Carpenter et al., 2022; Epperson et al., 2007; Milad et al., 2006). The neurovisceral integration model posits that vmHRV reflects the capacity of the central autonomous network (CAN), which is responsible for regulatory processes on behavioral, cognitive, and autonomous levels (Thayer \& Lane, 2000, 2009). Fear learning, mediated within the CAN, is suggested to be indicative of vmHRV's capacity for successful VI regulation (Battaglia \& Thayer, 2022). Given the GABAergic mediation of central inhibitory functional connectivity in the CAN, which may be affected by ALLO fluctuations, this thesis proposes that fluctuating CAN activity in the luteal phase contributes to diverse aversive symptoms in PMS. A research program was designed to empirically test these propositions. Study 1 investigated fear discrimination during different menstrual cycle phases and its interaction with vmHRV, revealing nuanced effects on acoustic startle response and skin conductance response. While there was heightened fear discrimination in acoustic startle responses in participants in the luteal phase, there was an interaction between menstrual cycle phase and vmHRV in skin conductance responses. In this measure, heightened fear discrimination during the luteal phase was only visible in individuals with high resting vmHRV; those with low vmHRV showed reduced fear discrimination and higher overall responses. Despite affecting the vast majority of menstruating people, there are very limited tools available to reliably assess these symptoms in the German speaking area. Study 2 aimed at closing this gap, by translating and validating a German version of the short version of the Premenstrual Assessment Form (Allen et al., 1991), providing a reliable tool for future investigations, which closes the gap in PMS questionnaires in the German-speaking research area. Study 3 employed a diary study paradigm to explore daily associations between vmHRV and PMS symptoms. The results showed clear simultaneous fluctuations between the two constructs with a peak in PMS and a low point in vmHRV a few days before menstruation onset. The association between vmHRV and PMS was driven by psychological PMS symptoms. Based on the theoretical considerations regarding the neurovisceral perspective on PMS, another interesting construct to consider is attentional control, as it is closely related to functions of the CAN. Study 4 delved into attentional control and vmHRV differences between menstrual cycle phases, demonstrating an interaction between cycle phase and PMS symptoms. In a pilot, we found reduced vmHRV and attentional control during the luteal phase only in participants who reported strong PMS. While Studies 1-4 provided evidence for the mechanisms underlying PMS, Studies 5 and 6 investigated short- and long-term intervention protocols to ameliorate PMS symptomatology. Study 5 explored the potential of heart rate variability biofeedback (HRVB) in alleviating PMS symptoms and a number of other outcome measures. In a waitlist-control design, participants underwent a 4-week smartphone-based HRVB intervention. The results revealed positive effects on PMS, with larger effect sizes on psychological symptoms, as well as on depressive symptoms, anxiety/stress and attentional control. Finally, Study 6 examined the acute effects of HRVB on attentional control. The study found positive impact but only in highly stressed individuals. The thesis, based on this comprehensive research program, expands our understanding of PMS as an outcome of CAN fluctuations mediated by GABAA receptor reactivity. The results largely support the model. These findings not only deepen our understanding of PMS but also offer potential avenues for therapeutic interventions. The promising results of smartphone-based HRVB training suggest a non-pharmacological approach to managing PMS symptoms, although further research is needed to confirm its efficacy. In conclusion, this thesis illuminates the complex web of factors contributing to PMS, providing valuable insights into its etiological underpinnings and potential interventions. By elucidating the relationships between hormonal fluctuations, CAN activity, and psychological responses, this research contributes to more effective treatments for individuals grappling with the challenges of PMS. The findings hold promise for improving the quality of life for those affected by this prevalent and often debilitating condition.}, language = {en} } @techreport{ClausenStieglitzWloka2023, author = {Clausen, S{\"u}nje and Stieglitz, Stefan and Wloka, Michelle}, title = {Between reality \& fantasy}, series = {Communication insights}, volume = {19}, journal = {Communication insights}, publisher = {Academic Society for Management \& Communication}, address = {Leipzig}, issn = {2749-893X}, doi = {10419/280991}, pages = {21}, year = {2023}, abstract = {Synthetische Medien erm{\"o}glichen die zunehmend automatisierte Erstellung virtueller Influencer, von denen bereits einige Millionen Follower in sozialen Medien gewonnen haben. Unter der Leitung von Professor Stefan Stieglitz und S{\"u}nje Clausen (Universit{\"a}t Potsdam) und in Kooperation mit Sanofi hat ein Forschungsprojekt untersucht, wie computergenerierten Charaktere f{\"u}r die Influencer-Kommunikation im Unternehmensumfeld genutzt werden k{\"o}nnen. N{\"a}here Informationen zu den Forschungsergebnissen k{\"o}nnen in der Communication Insights nachgelesen werden: eine kurze Einf{\"u}hrung in die Influencer-Kommunikation, potenziellen Vorteile als auch Herausforderungen von virtuellen Influencern, Tipps f{\"u}r den Prozess der Gestaltung und Nutzung eines virtuellen Influencers.}, language = {en} } @article{GischRobertBerlinetal.2022, author = {Gisch, Ulrike Alexandra and Robert, Margaux and Berlin, Noemi and Nebout, Antoine and Etile, Fabrice and Teyssier, Sabrina and Andreeva, Valentina A. and Hercberg, Serge and Touvier, Mathilde and Peneau, Sandrine}, title = {Mastery is associated with weight status, food intake, snacking, and eating disorder symptoms in the NutriNet-Sante cohort study}, series = {Frontiers in Nutrition}, volume = {9}, journal = {Frontiers in Nutrition}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-861X}, doi = {10.3389/fnut.2022.871669}, pages = {13}, year = {2022}, abstract = {Mastery is a psychological resource that is defined as the extent to which individuals perceive having control over important circumstances of their lives. Although mastery has been associated with various physical and psychological health outcomes, studies assessing its relationship with weight status and dietary behavior are lacking. The aim of this cross-sectional study was to assess the relationship between mastery and weight status, food intake, snacking, and eating disorder (ED) symptoms in the NutriNet-Sante cohort study. Mastery was measured with the Pearlin Mastery Scale (PMS) in 32,588 adults (77.45\% female), the mean age was 50.04 (14.53) years. Height and weight were self-reported. Overall diet quality and food group consumption were evaluated with >= 3 self-reported 24-h dietary records (range: 3-27). Snacking was assessed with an ad-hoc question. ED symptoms were assessed with the Sick-Control-One-Fat-Food Questionnaire (SCOFF). Linear and logistic regression analyses were conducted to assess the relationship between mastery and weight status, food intake, snacking, and ED symptoms, controlling for sociodemographic and lifestyle characteristics. Females with a higher level of mastery were less likely to be underweight (OR: 0.88; 95\%CI: 0.84, 0.93), overweight [OR: 0.94 (0.91, 0.97)], or obese [class I: OR: 0.86 (0.82, 0.90); class II: OR: 0.76 (0.71, 0.82); class III: OR: 0.77 (0.69, 0.86)]. Males with a higher level of mastery were less likely to be obese [class III: OR: 0.75 (0.57, 0.99)]. Mastery was associated with better diet quality overall, a higher consumption of fruit and vegetables, seafood, wholegrain foods, legumes, non-salted oleaginous fruits, and alcoholic beverages and with a lower consumption of meat and poultry, dairy products, sugary and fatty products, milk-based desserts, and sweetened beverages. Mastery was also associated with lower snacking frequency [OR: 0.89 (0.86, 0.91)] and less ED symptoms [OR: 0.73 (0.71, 0.75)]. As mastery was associated with favorable dietary behavior and weight status, targeting mastery might be a promising approach in promoting healthy behaviors.}, language = {en} } @techreport{StieglitzZerfassWlokaetal.2024, author = {Stieglitz, Stefan and Zerfaß, Ansgar and Wloka, Michelle and Clausen, S{\"u}nje}, title = {Communications trend radar 2024}, series = {Communication insights}, volume = {20}, journal = {Communication insights}, publisher = {Academic Society for Management \& Communication}, address = {Leipzig}, issn = {2749-893X}, doi = {10419/284410}, pages = {43}, year = {2024}, abstract = {What does the future hold for corporate communications? The Communications Trend Radar is an applied research project. On an annual basis, it identifies relevant trends for corporate communications from the fields of society, management, and technology. The research team at the University of Potsdam (Professor Stefan Stieglitz, S{\"u}nje Clausen, MS.) and Leipzig University (Professor Ansgar Zerfass, Dr Michelle Wloka) identified the following trends for 2024: Information Inflation, AI Literacy, Workforce Shift, Content Integrity, Decoding Humans. More information on the trends can be found in the Communications Trend Radar Report 2024}, language = {en} } @article{SchmidtReilJeskeetal.2021, author = {Schmidt, Sabrina and Reil, Daniela and Jeske, Kathrin and Drewes, Stephan and Rosenfeld, Ulrike and Fischer, Stefan and Spierling, Nastasja G. and Labutin, Anton and Heckel, Gerald and Jacob, Jens and Ulrich, Rainer G. and Imholt, Christian}, title = {Spatial and temporal dynamics and molecular evolution of Tula orthohantavirus in German vole populations}, series = {Viruses / Molecular Diversity Preservation International (MDPI)}, volume = {13}, journal = {Viruses / Molecular Diversity Preservation International (MDPI)}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {1999-4915}, doi = {10.3390/v13061132}, pages = {17}, year = {2021}, abstract = {Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.}, language = {en} } @article{PetreskaSandevLenzi2021, author = {Petreska, Irina and Sandev, Trifce and Lenzi, Ervin Kaminski}, title = {Comb-like geometric constraints leading to emergence of the time-fractional Schr{\"o}dinger equation}, series = {Modern physics letters : A, Particles and fields, gravitation, cosmology, nuclear physics}, volume = {36}, journal = {Modern physics letters : A, Particles and fields, gravitation, cosmology, nuclear physics}, number = {14}, publisher = {World Scientific}, address = {Singapore}, issn = {0217-7323}, doi = {10.1142/S0217732321300056}, pages = {23}, year = {2021}, abstract = {This paper presents an overview over several examples, where the comb-like geometric constraints lead to emergence of the time-fractional Schrodinger equation. Motion of a quantum object on a comb structure is modeled by a suitable modification of the kinetic energy operator, obtained by insertion of the Dirac delta function in the Laplacian. First, we consider motion of a free particle on two- and three-dimensional comb structures, and then we extend the study to the interacting cases. A general form of a nonlocal term, which describes the interactions of the particle with the medium, is included in the Hamiltonian, and later on, the cases of constant and Dirac delta potentials are analyzed. At the end, we discuss the case of non-integer dimensions, considering separately the case of fractal dimension between one and two, and the case of fractal dimension between two and three. All these examples show that even though we are starting with the standard time-dependent Schrodinger equation on a comb, the time-fractional equation for the Green's functions appears, due to these specific geometric constraints.}, language = {en} } @inproceedings{LossowSchwarzKoppetal.2021, author = {Loßow, Kristina and Schwarz, Maria and Kopp, Johannes and Schwerdtle, Tanja and Kipp, Anna Patricia}, title = {Age- and sex-dependent changes of trace elements and redox parameters in mice}, series = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research}, volume = {165}, booktitle = {Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research}, number = {Suppl. 1}, publisher = {Elsevier}, address = {New York}, issn = {0891-5849}, doi = {10.1016/j.freeradbiomed.2020.12.346}, pages = {34}, year = {2021}, language = {en} } @article{CabalarFandinoFarinasdelCerro2021, author = {Cabalar, Pedro and Fandi{\~n}o, Jorge and Fari{\~n}as del Cerro, Luis}, title = {Splitting epistemic logic programs}, series = {Theory and practice of logic programming / publ. for the Association for Logic Programming}, volume = {21}, journal = {Theory and practice of logic programming / publ. for the Association for Logic Programming}, number = {3}, publisher = {Cambridge Univ. Press}, address = {Cambridge [u.a.]}, issn = {1471-0684}, doi = {10.1017/S1471068420000058}, pages = {296 -- 316}, year = {2021}, abstract = {Epistemic logic programs constitute an extension of the stable model semantics to deal with new constructs called subjective literals. Informally speaking, a subjective literal allows checking whether some objective literal is true in all or some stable models. As it can be imagined, the associated semantics has proved to be non-trivial, since the truth of subjective literals may interfere with the set of stable models it is supposed to query. As a consequence, no clear agreement has been reached and different semantic proposals have been made in the literature. Unfortunately, comparison among these proposals has been limited to a study of their effect on individual examples, rather than identifying general properties to be checked. In this paper, we propose an extension of the well-known splitting property for logic programs to the epistemic case. We formally define when an arbitrary semantics satisfies the epistemic splitting property and examine some of the consequences that can be derived from that, including its relation to conformant planning and to epistemic constraints. Interestingly, we prove (through counterexamples) that most of the existing approaches fail to fulfill the epistemic splitting property, except the original semantics proposed by Gelfond 1991 and a recent proposal by the authors, called Founded Autoepistemic Equilibrium Logic.}, language = {en} } @article{BlankeKwiatekGoebeletal.2021, author = {Blanke, Aglaja and Kwiatek, Grzegorz and Goebel, Thomas H. W. and Bohnhoff, Marco and Dresen, Georg}, title = {Stress drop-magnitude dependence of acoustic emissions during laboratory stick-slip}, series = {Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society}, volume = {224}, journal = {Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggaa524}, pages = {1372 -- 1381}, year = {2021}, abstract = {Earthquake source parameters such as seismic stress drop and corner frequency are observed to vary widely, leading to persistent discussion on potential scaling of stress drop and event size. Physical mechanisms that govern stress drop variations arc difficult to evaluate in nature and are more readily studied in controlled laboratory experiments. We perform two stick-slip experiments on fractured (rough) and cut (smooth) Westerly granite samples to explore fault roughness effects on acoustic emission (AE) source parameters. We separate large stick-slip events that generally saturate the seismic recording system from populations of smaller AE events which are sensitive to fault stresses prior to slip. AE event populations show many similarities to natural seismicity and may be interpreted as laboratory equivalent of natural microseismic events. We then compare the temporal evolution of mechanical data such as measured stress release during slip to temporal changes in stress drops derived from Alis using the spectral ratio technique. We report on two primary observations: (1) In contrast to most case studies for natural earthquakes, we observe a strong increase in seismic stress drop with AE size. (2) The scaling of stress drop with magnitude is governed by fault roughness, whereby the rough fault shows a more rapid increase of the stress drop magnitude relation with progressing large stick-slip events than the smooth fault. The overall range of AE sizes on the rough surface is influenced by both the average grain size and the width of the fault core. The magnitudes of the smallest AE events on smooth faults may also be governed by grain size. However, AEs significantly grow beyond peak roughness and the width of the fault core. Our laboratory tests highlight that source parameters vary substantially in the presence of fault zone heterogeneity (i.e. roughness and narrow grain size distribution), which may affect seismic energy partitioning and static stress drops of small and large AE events.}, language = {en} } @article{BelluardoScherzSantosetal.2022, author = {Belluardo, Francesco and Scherz, Mark D. and Santos, Barbara and Andreone, Franco and Antonelli, Alexandre and Glaw, Frank and Munoz-Pajares, A. Jesus and Randrianirina, Jasmin E. and Raselimanana, Achille P. and Vences, Miguel and Crottini, Angelica}, title = {Molecular taxonomic identification and species-level phylogeny of the narrow-mouthed frogs of the genus Rhombophryne (Anura: Microhylidae: Cophylinae) from Madagascar}, series = {Systematics and biodiversity}, volume = {20}, journal = {Systematics and biodiversity}, number = {1}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1477-2000}, doi = {10.1080/14772000.2022.2039320}, pages = {1 -- 13}, year = {2022}, abstract = {The study of diamond frogs (genus Rhombophryne, endemic to Madagascar) has been historically hampered by the paucity of available specimens, because of their low detectability in the field. Over the last 10 years, 13 new taxa have been described, and 20 named species are currently recognized. Nevertheless, undescribed diversity within the genus is probably large, calling for a revision of the taxonomic identification of published records and an update of the known distribution of each lineage. Here we generate DNA sequences of the mitochondrial 16S rRNA gene of all specimens available to us, revise the genetic data from public databases, and report all deeply divergent mitochondrial lineages of Rhombophryne identifiable from these data. We also generate a multi-locus dataset (including five mitochondrial and eight nuclear markers; 9844 bp) to infer a species-level phylogenetic hypothesis for the diversification of this genus and revise the distribution of each lineage. We recognize a total of 10 candidate species, two of which are identified here for the first time. The genus Rhombophryne is here proposed to be divided into six main species groups, and phylogenetic relationships among some of them are not fully resolved. These frogs are primarily distributed in northern Madagascar, and most species are known from only few localities. A previous record of this genus from the Tsingy de Bemaraha (western Madagascar) is interpreted as probably due to a mislabelling and should not be considered further unless confirmed by new data. By generating this phylogenetic hypothesis and providing an updated distribution of each lineage, our findings will facilitate future species descriptions, pave the way for evolutionary studies, and provide valuable information for the urgent conservation of diamond frogs.}, language = {en} } @article{ChevalereLazaridesYunetal.2023, author = {Cheval{\`e}re, Johann and Lazarides, Rebecca and Yun, Hae Seon and Henke, Anja and Lazarides, Claudia and Pinkwart, Niels and Hafner, Verena V.}, title = {Do instructional strategies considering activity emotions reduce students' boredom in a computerized open-ended learning environment?}, series = {Computers and education}, volume = {196}, journal = {Computers and education}, publisher = {Elsevier}, issn = {1873-782X}, doi = {10.1016/j.compedu.2023.104741}, year = {2023}, abstract = {Providing students with efficient instruction tailored to their individual characteristics in the cognitive and affective domains is an important goal in research on computer-based learning. This is especially important when seeking to enhance students' learning experience, such as by counteracting boredom, a detrimental emotion for learning. However, studies comparing instructional strategies triggered by either cognitive or emotional characteristics are surprisingly scarce. In addition, little research has examined the impact of these types of instructional strategies on performance and boredom trajectories within a lesson. In the present study, we compared the effectiveness of an intelligent tutoring system that adapted variable levels of hint details to a combination of students' dynamic, self-reported emotions and task performance (i.e., the experimental condition) to a traditional hint delivery approach consisting of a progressive, incremental supply of details following students' failures (i.e., the control condition). Linear mixed models of time-related changes in task performance and the intensity of boredom over two 1-h sessions showed that students (N = 104) in the two conditions exhibited equivalent progression in task performance and similar trajectories in boredom intensity. However, a consideration of students' achievement levels in the analyses (i.e., their final performance on the task) revealed that higher achievers in the experimental condition showed a reduction in boredom during the first session, suggesting possible benefits of using emotional information to increase the contingency of the hint delivery strategy and improve students' learning experience.}, language = {en} } @article{LazaridesChevalere2021, author = {Lazarides, Rebecca and Cheval{\`e}re, Johann}, title = {Artificial intelligence and education: Addressing the variability in learners' emotion and motivation with adaptive teaching assistants}, series = {Bildung und Erziehung}, volume = {74}, journal = {Bildung und Erziehung}, number = {3}, publisher = {Vandenhoeck \& Ruprecht}, issn = {0006-2456}, doi = {10.13109/buer.2021.74.3.264}, pages = {264 -- 279}, year = {2021}, abstract = {One of the main challenges of education in modern societies is to effectively address the variability of students in academic learning settings. Students vary in terms of their individual learning preconditions, such as achievement and preknowledge, but also motivation and emotion. Teachers, in turn, have limited resources to provide each learner with individually tailored instruction. This research overview reviews research on artificially intelligent teaching assistants and their role in providing adaptive learning opportunities in relation to learners' heterogeneous individual learning preconditions in the field of motivation and emotion.}, language = {en} } @article{StieglitzMirbabaieDeubeletal.2024, author = {Stieglitz, Stefan and Mirbabaie, Milad and Deubel, Annika and Braun, Lea-Marie and Kissmer, Tobias}, title = {Corrigendum to "The potential of digital nudging to bridge the gap between environmental attitude and behavior in the usage of smart home applications" [International Journal of Information Management 72 (2023) 102665]}, series = {International journal of information management}, volume = {76}, journal = {International journal of information management}, publisher = {Elsevier}, address = {Oxford}, issn = {0268-4012}, doi = {10.1016/j.ijinfomgt.2024.102774}, pages = {2}, year = {2024}, abstract = {We would like to inform the readers and editors of the journal that we have discovered some errors in the references of our paper. These errors were brought to our attention by a reader who noticed some inconsistencies between the citations in the text and the bibliography. Upon further investigation, we realized that our literature management software had mistakenly linked some of the references to wrong or non-existent sources. We apologize for this oversight and assure you that it did not affect the validity or quality of our arguments and results, which were based on the correct sources. Below you find a list of the incorrect references along with their corresponding correct ones. We hope that this correction statement will clarify any confusion or misunderstanding that may have arisen from this mistake. The authors would like to apologise for any inconvenience caused.}, language = {en} } @article{MarxBlancoAmaraletal.2023, author = {Marx, Julian and Blanco, Beatriz and Amaral, Adriana and Stieglitz, Stefan and Aquino, Maria Clara}, title = {Combating misinformation with internet culture}, series = {Internet research}, volume = {33}, journal = {Internet research}, number = {5}, publisher = {Emerald}, address = {Bingley}, issn = {1066-2243}, doi = {10.1108/INTR-07-2022-0573}, pages = {1990 -- 2012}, year = {2023}, abstract = {Purpose This study investigates the communication behavior of public health organizations on Twitter during the COVID-19 vaccination campaign in Brazil. It contributes to the understanding of the organizational framing of health communication by showcasing several instances of framing devices that borrow from (Brazilian) internet culture. The investigation of this case extends the knowledge by providing a rich description of the organizational framing of health communication to combat misinformation in a politically charged environment. Design/methodology/approach The authors collected a Twitter dataset of 77,527 tweets and analyzed a purposeful subsample of 536 tweets that contained information provided by Brazilian public health organizations about COVID-19 vaccination campaigns. The data analysis was carried out quantitatively and qualitatively by combining social media analytics techniques and frame analysis. Findings The analysis showed that Brazilian health organizations used several framing devices that have been identified by previous literature such as hashtags, links, emojis or images. However, the analysis also unearthed hitherto unknown visual framing devices for misinformation prevention and debunking that borrow from internet culture such as "infographics," "pop culture references" and "internet-native symbolism." Research limitations/implications First, the identification of framing devices relating to internet culture add to our understanding of the so far little addressed framing of misinformation combat messages. The case of Brazilian health organizations provides a novel perspective to knowledge by offering a notion of internet-native symbols (e.g. humor, memes) and popular culture references for misinformation combat, including misinformation prevention. Second, this study introduces a frontier of political contextualization to misinformation research that does not relate to the partisanship of the spreaders but that relates to the political dilemmas of public organizations with a commitment to provide accurate information to citizens. Practical implications The findings inform decision-makers and public health organizations about framing devices that are tailored to internet-native audiences and can guide strategies to carry out information campaigns in misinformation-laden social media environments. Social implications The findings of this case study expose the often-overlooked cultural peculiarities of framing information campaigns on social media. The report of this study from a country in the Global South helps to contrast several assumptions and strategies that are prevalent in (health) discourses in Western societies and scholarship. Originality/value This study uncovers unconventional and barely addressed framing devices of health organizations operating in Brazil, which provides a novel perspective to the body of research on misinformation. It contributes to existing knowledge about frame analysis and broadens the understanding of frame devices borrowing from internet culture. It is a call for a frontier in misinformation research that deals with internet culture as part of organizational strategies for successful misinformation combat.}, language = {en} } @article{NitzscheKleebergHoffmannetal.2022, author = {Nitzsche, Kai Nils and Kleeberg, Andreas and Hoffmann, Carsten and Merz, Christoph and Premke, Katrin and Gessler, Arthur and Sommer, Michael and Kayler, Zachary E.}, title = {Kettle holes reflect the biogeochemical characteristics of their catchment area and the intensity of the element-specific input}, series = {Journal of soils and sediments : protection, risk assessment and remediation}, volume = {22}, journal = {Journal of soils and sediments : protection, risk assessment and remediation}, number = {3}, publisher = {Springer}, address = {Heidelberg}, issn = {1439-0108}, doi = {10.1007/s11368-022-03145-8}, pages = {994 -- 1009}, year = {2022}, abstract = {Purpose Kettle holes are small inland water bodies known to be dominated by terrigenous material; however, the processes and structures that drive the enrichment and depletion of specific geochemical elements in the water column and kettle hole sediment remain unclear. We hypothesized that the mobile elements (Ca, Fe, K, P) behave different from each other in their transport, intermediate soil retention, and final accumulation in the kettle hole sediment. Methods Topsoils from transects spanning topographic positions from erosional to depositional areas, sediment cores, shallow groundwater, and kettle hole water of two glacial kettle holes in NE Germany (Rittgarten (RG) and Kraatz (KR)) were collected. The Fe, Ca, K, and total P (TP) concentrations were quantified and additionally the major anions in shallow groundwater and kettle hole water. The element-specific mobilization, relocation, and, finally, accumulation in the sediment were investigated by enrichment factors. Furthermore, a piper diagram was used to estimate groundwater flow directions and pond-internal processes. Results At KR only, the upper 10 cm of the kettle hole sediment reflected the relative element composition of the eroded terrestrial soils. The sediment from both kettle holes was enriched in Ca, Fe, K, and P compared to topsoils, indicating several possible processes including the input of clay and silt sized particles enriched in these elements, fertilizer input, and pond-internal processes including biogenic calcite and hydroxyapatite precipitation, Fe-P binding (KR), FeSx formation (RG), and elemental fixation and deposition via floating macrophytes (RG). High Ca concentrations in the kettle hole water indicated a high input of Ca from shallow groundwater inflow, while Ca precipitation in the kettle hole water led to lower Ca concentration in groundwater outflow. Conclusions The considerable element losses in the surrounding soils and the inputs into the kettle holes should be addressed by comprehensive soil and water protection measures, i.e., avoiding tillage, fertilizing conservatively, and creating buffer zones.}, language = {en} } @phdthesis{Sareeto2024, author = {Sareeto, Apatsara}, title = {Algebraic proberties of a subsemigroup of the symmetric inverse semigroup}, school = {Universit{\"a}t Potsdam}, pages = {92}, year = {2024}, language = {en} } @article{BiermannNowakBraunetal.2024, author = {Biermann, Kaija and Nowak, Bianca and Braun, Lea-Marie and Taddicken, Monika and Kr{\"a}mer, Nicole C. and Stieglitz, Stefan}, title = {Does scientific evidence sell?}, series = {Science communication}, volume = {0}, journal = {Science communication}, publisher = {Sage}, address = {Thousand Oaks, Calif.}, issn = {1075-5470}, doi = {10.1177/10755470241249468}, pages = {34}, year = {2024}, abstract = {Examining the dissemination of evidence on social media, we analyzed the discourse around eight visible scientists in the context of COVID-19. Using manual (N = 1,406) and automated coding (N = 42,640) on an account-based tracked Twitter/X dataset capturing scientists' activities and eliciting reactions over six 2-week periods, we found that visible scientists' tweets included more scientific evidence. However, public reactions contained more anecdotal evidence. Findings indicate that evidence can be a message characteristic leading to greater tweet dissemination. Implications for scientists, including explicitly incorporating scientific evidence in their communication and examining evidence in science communication research, are discussed.}, language = {en} } @article{GarbulowskiSmolinskaCabuketal.2022, author = {Garbulowski, Mateusz and Smolinska, Karolina and {\c{C}}abuk, Uğur and Yones, Sara A. and Celli, Ludovica and Yaz, Esma Nur and Barrenas, Fredrik and Diamanti, Klev and Wadelius, Claes and Komorowski, Jan}, title = {Machine learning-based analysis of glioma grades reveals co-enrichment}, series = {Cancers}, volume = {14}, journal = {Cancers}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2072-6694}, doi = {10.3390/cancers14041014}, pages = {19}, year = {2022}, abstract = {Simple Summary Gliomas are heterogenous types of cancer, therefore the therapy should be personalized and targeted toward specific pathways. We developed a methodology that corrected strong batch effects from The Cancer Genome Atlas datasets and estimated glioma grade-specific co-enrichment mechanisms using machine learning. Our findings created hypotheses for annotations, e.g., pathways, that should be considered as therapeutic targets. Gliomas develop and grow in the brain and central nervous system. Examining glioma grading processes is valuable for improving therapeutic challenges. One of the most extensive repositories storing transcriptomics data for gliomas is The Cancer Genome Atlas (TCGA). However, such big cohorts should be processed with caution and evaluated thoroughly as they can contain batch and other effects. Furthermore, biological mechanisms of cancer contain interactions among biomarkers. Thus, we applied an interpretable machine learning approach to discover such relationships. This type of transparent learning provides not only good predictability, but also reveals co-predictive mechanisms among features. In this study, we corrected the strong and confounded batch effect in the TCGA glioma data. We further used the corrected datasets to perform comprehensive machine learning analysis applied on single-sample gene set enrichment scores using collections from the Molecular Signature Database. Furthermore, using rule-based classifiers, we displayed networks of co-enrichment related to glioma grades. Moreover, we validated our results using the external glioma cohorts. We believe that utilizing corrected glioma cohorts from TCGA may improve the application and validation of any future studies. Finally, the co-enrichment and survival analysis provided detailed explanations for glioma progression and consequently, it should support the targeted treatment.}, language = {en} } @article{KupferBauervanRoesteletal.2022, author = {Kupfer, Thomas and Bauer, Evan B. and van Roestel, Jan and Bellm, Eric C. and Bildsten, Lars and Fuller, Jim and Prince, Thomas A. and Heber, Ulrich and Geier, Stephan and Green, Matthew J. and Kulkarni, Shrinivas R. and Bloemen, Steven and Laher, Russ R. and Rusholme, Ben and Schneider, David}, title = {Discovery of a Double-detonation Thermonuclear Supernova Progenitor}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, volume = {925}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {2041-8205}, doi = {10.3847/2041-8213/ac48f1}, pages = {10}, year = {2022}, abstract = {We present the discovery of a new double-detonation progenitor system consisting of a hot subdwarf B (sdB) binary with a white dwarf companion with a P (orb) = 76.34179(2) minutes orbital period. Spectroscopic observations are consistent with an sdB star during helium core burning residing on the extreme horizontal branch. Chimera light curves are dominated by ellipsoidal deformation of the sdB star and a weak eclipse of the companion white dwarf. Combining spectroscopic and light curve fits, we find a low-mass sdB star, M (sdB) = 0.383 +/- 0.028 M (circle dot) with a massive white dwarf companion, M (WD) = 0.725 +/- 0.026 M (circle dot). From the eclipses we find a blackbody temperature for the white dwarf of 26,800 K resulting in a cooling age of approximate to 25 Myr whereas our MESA model predicts an sdB age of approximate to 170 Myr. We conclude that the sdB formed first through stable mass transfer followed by a common envelope which led to the formation of the white dwarf companion approximate to 25 Myr ago. Using the MESA stellar evolutionary code we find that the sdB star will start mass transfer in approximate to 6 Myr and in approximate to 60 Myr the white dwarf will reach a total mass of 0.92 M (circle dot) with a thick helium layer of 0.17 M (circle dot). This will lead to a detonation that will likely destroy the white dwarf in a peculiar thermonuclear supernova. PTF1 J2238+7430 is only the second confirmed candidate for a double-detonation thermonuclear supernova. Using both systems we estimate that at least approximate to 1\% of white dwarf thermonuclear supernovae originate from sdB+WD binaries with thick helium layers, consistent with the small number of observed peculiar thermonuclear explosions.}, language = {en} } @article{NajmanSobelMillaretal.2022, author = {Najman, Yani and Sobel, Edward and Millar, Ian and Luan, Xiwu and Zapata, Sebastian and Garzanti, Eduardo and Parra, Mauricio and Vezzoli, Giovanni and Zhang, Peng and Wa Aung, Day and Paw, Saw Mu Tha Lay and Lwin, Thae Naung}, title = {The timing of collision between Asia and the West Burma Terrane, and the development of the Indo-Burman Ranges}, series = {Tectonics}, volume = {41}, journal = {Tectonics}, number = {7}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0278-7407}, doi = {10.1029/2021TC007057}, pages = {22}, year = {2022}, abstract = {The West Burma Terrane (WBT) is a small terrane bounded to the east by the Asian Sibumasu Block and to the west by the Indo-Burman Ranges (IBR), the latter being an exhumed accretionary prism that formed during subduction of Indian oceanic lithosphere beneath Asia. Understanding the geological history of the WBT is important for reconstruction of the closure history of the Tethys Ocean and India-Asia collision. Currently there are major discrepancies in the proposed timings of collision between the WBT with both India and Asia; whether the WBT collided with India or Asia first is debated, and proposed timings of collisions stretch from the Mesozoic to the Cenozoic. We undertook a multi-technique provenance study involving petrography, detrital zircon U-Pb and Hf analyses, rutile U-Pb analyses and Sr-Nd bulk rock analyses on sediments of the Central Myanmar Basins of the WBT. We determined that the first arrival of Asian material into the basin occurred after the earliest late Eocene and by the early Oligocene, thus placing a minimum constraint on the timing of WBT-Asia collision. Our low temperature thermochronological study of the IBR records two periods of exhumation, in the early-middle Eocene, and at the Oligo-Miocene boundary. The Eocene event may be associated with the collision of the WBT with India. The later event at the Oligo-Miocene boundary may be associated with changes in wedge dynamics resulting from increased sediment supply to the system; however a number of other possible causes provide equally plausible explanations for both events.}, language = {en} } @article{JebabliZouhalBoullosaetal.2022, author = {Jebabli, Nidhal and Zouhal, Hassane and Boullosa, Daniel and Govindasamy, Karuppasamy and Tourny, Claire and Hackney, Anthony C. and Granacher, Urs and Ben Abderrahman, Abderraouf}, title = {The effects of preferred music and its timing on performance, pacing, and psychophysiological responses during the 6-min test}, series = {Journal of human kinetics}, volume = {82}, journal = {Journal of human kinetics}, number = {1}, publisher = {Academy of Physical Education}, address = {Katowice}, issn = {1640-5544}, doi = {10.2478/hukin-2022-0038}, pages = {123 -- 133}, year = {2022}, abstract = {The aim of this study was to investigate the effects of listening to preferred music during a warm up or exercise, on performance during a 6-min all-out exercise test (6-MT) in young adult males. Twenty-five healthy males volunteered to participate in this study. Following a within subject design, participants performed three test conditions (MDT: music during the test; MDW: music during the warm-up; WM: without music) in random order. Outcomes included mean running speed over the 6-min test (MRS6), total distance covered (TDC), heart rate responses (HRpeak, HRmean), blood lactate (3-min after the test), and the rating of perceived exertion (RPE); additionally, feeling scale scores were recorded. Listening to preferred music during running resulted in significant TDC (Delta up arrow 10\%, p=0.006, ES=0.80) and MRS6 (Delta up arrow 14\%, p=0.012, ES=1.02) improvement during the 6-MT, improvement was also noted for the warm-up with music condition (TDC:Delta up arrow 8\%, p=0.028, ES=0.63; MRS6:Delta up arrow 8\%, p=0.032, ES=0.61). A similar reverse "J-shaped" pacing profile was detected during the three conditions. Blood lactate was lower in the MDT condition by 8\% (p=0.01, ES=1.10), but not the MDW condition, compared to MW. In addition, no statistically significant differences were found between the test sessions for the HR, RPE, and feeling scale scores. In conclusion, listening to music during exercise testing would be more beneficial for optimal TDC and MRS6 performances compared to MDW and WM.}, language = {en} } @article{AgarwalHamidizadehBier2023, author = {Agarwal, Saloni and Hamidizadeh, Mojdeh and Bier, Frank Fabian}, title = {Detection of reverse transcriptase LAMP-amplified nucleic acid from oropharyngeal viral swab samples using biotinylated DNA probes through a lateral flow assay}, series = {Biosensors : open access journal}, volume = {13}, journal = {Biosensors : open access journal}, number = {11}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios13110988}, pages = {15}, year = {2023}, abstract = {This study focuses on three key aspects: (a) crude throat swab samples in a viral transport medium (VTM) as templates for RT-LAMP reactions; (b) a biotinylated DNA probe with enhanced specificity for LFA readouts; and (c) a digital semi-quantification of LFA readouts. Throat swab samples from SARS-CoV-2 positive and negative patients were used in their crude (no cleaning or pre-treatment) forms for the RT-LAMP reaction. The samples were heat-inactivated but not treated for any kind of nucleic acid extraction or purification. The RT-LAMP (20 min processing time) product was read out by an LFA approach using two labels: FITC and biotin. FITC was enzymatically incorporated into the RT-LAMP amplicon with the LF-LAMP primer, and biotin was introduced using biotinylated DNA probes, specifically for the amplicon region after RT-LAMP amplification. This assay setup with biotinylated DNA probe-based LFA readouts of the RT-LAMP amplicon was 98.11\% sensitive and 96.15\% specific. The LFA result was further analysed by a smartphone-based IVD device, wherein the T-line intensity was recorded. The LFA T-line intensity was then correlated with the qRT-PCR Ct value of the positive swab samples. A digital semi-quantification of RT-LAMP-LFA was reported with a correlation coefficient of R2 = 0.702. The overall RT-LAMP-LFA assay time was recorded to be 35 min with a LoD of three RNA copies/µL (Ct-33). With these three advancements, the nucleic acid testing-point of care technique (NAT-POCT) is exemplified as a versatile biosensor platform with great potential and applicability for the detection of pathogens without the need for sample storage, transportation, or pre-processing.}, language = {en} } @article{NumbergerZoccaratoWoodhouseetal.2022, author = {Numberger, Daniela and Zoccarato, Luca and Woodhouse, Jason Nicholas and Ganzert, Lars and Sauer, Sascha and Garc{\´i}a M{\´a}rquez, Jaime Ricardo and Domisch, Sami and Grossart, Hans-Peter and Greenwood, Alex}, title = {Urbanization promotes specific bacteria in freshwater microbiomes including potential pathogens}, series = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, volume = {845}, journal = {The science of the total environment : an international journal for scientific research into the environment and its relationship with man}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0048-9697}, doi = {10.1016/j.scitotenv.2022.157321}, pages = {13}, year = {2022}, abstract = {Freshwater ecosystems are characterized by complex and highly dynamic microbial communities that are strongly structured by their local environment and biota. Accelerating urbanization and growing city populations detrimentally alter freshwater environments. To determine differences in freshwater microbial communities associated with urban-ization, full-length 16S rRNA gene PacBio sequencing was performed in a case study from surface waters and sedi-ments from a wastewater treatment plant, urban and rural lakes in the Berlin-Brandenburg region, Northeast Germany. Water samples exhibited highly habitat specific bacterial communities with multiple genera showing clear urban signatures. We identified potentially harmful bacterial groups associated with environmental parameters specific to urban habitats such as Alistipes, Escherichia/Shigella, Rickettsia and Streptococcus. We demonstrate that urban-ization alters natural microbial communities in lakes and, via simultaneous warming and eutrophication and creates favourable conditions that promote specific bacterial genera including potential pathogens. Our findings are evidence to suggest an increased potential for long-term health risk in urbanized waterbodies, at a time of rapidly expanding global urbanization. The results highlight the urgency for undertaking mitigation measures such as targeted lake restoration projects and sustainable water management efforts.}, language = {en} } @article{ZavorkaBlancoChaguacedaetal.2023, author = {Zavorka, Libor and Blanco, Andreu and Chaguaceda, Fernando and Cucherousset, Julien and Killen, Shaun S. and Lienart, Camilla and Mathieu-Resuge, Margaux and Nemec, Pavel and Pilecky, Matthias and Scharnweber, Inga Kristin and Twining, Cornelia W. and Kainz, Martin J.}, title = {The role of vital dietary biomolecules in eco-evo-devo dynamics}, series = {Trends in ecology and evolution}, volume = {38}, journal = {Trends in ecology and evolution}, number = {1}, publisher = {Cell Press}, address = {Cambridge}, issn = {0169-5347}, doi = {10.1016/j.tree.2022.08.010}, pages = {72 -- 84}, year = {2023}, abstract = {The physiological dependence of animals on dietary intake of vitamins, amino acids, and fatty acids is ubiquitous. Sharp differences in the availability of these vital dietary biomolecules among different resources mean that consumers must adopt a range of strategies to meet their physiological needs. We review the emerging work on omega-3 long-chain polyunsaturated fatty acids, focusing predominantly on predator-prey interactions, to illustrate that trade-off between capacities to consume resources rich in vital biomolecules and internal synthesis capacity drives differences in phenotype and fitness of consumers. This can then feedback to impact ecosystem functioning. We outline how focus on vital dietary biomolecules in eco-eco-devo dynamics can improve our understanding of anthropogenic changes across multiple levels of biological organization.}, language = {en} } @article{JaiserAkperovTimazhevetal.2023, author = {Jaiser, Ralf and Akperov, Mirseid and Timazhev, A. and Romanowsky, Erik and Handorf, D{\"o}rthe and Mokhov, I. I.}, title = {Linkages between arctic and mid-latitude weather and climate}, series = {Meteorologische Zeitschrift}, volume = {32}, journal = {Meteorologische Zeitschrift}, number = {3}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {0941-2948}, doi = {10.1127/metz/2023/1154}, pages = {173 -- 194}, year = {2023}, abstract = {The study addresses the question, if observed changes in terms of Arctic-midlatitude linkages during winter are driven by Arctic Sea ice decline alone or if the increase of global sea surface temperatures plays an additional role. We compare atmosphere-only model experiments with ECHAM6 to ERA-Interim Reanalysis data. The model sensitivity experiment is implemented as a set of four combinations of sea ice and sea surface temperature boundary conditions. Atmospheric circulation regimes are determined and evaluated in terms of their cyclone and blocking characteristics and changes in frequency during winter. As a prerequisite, ECHAM6 reproduces general features of circulation regimes very well. Tropospheric changes induced by the change of boundary conditions are revealed and further impacts on the large-scale circulation up into the stratosphere are investigated. In early winter, the observed increase of atmospheric blocking in the region between Scandinavia and the Urals are primarily related to the changes in sea surface temperatures. During late winter, we f nd a weakened polar stratospheric vortex in the reanalysis that further impacts the troposphere. In the model sensitivity study a climatologically weakened polar vortex occurs only if sea ice is reduced and sea surface temperatures are increased together. This response is delayed compared to the reanalysis. The tropospheric response during late winter is inconclusive in the model, which is potentially related to the weak and delayed response in the stratosphere. The model experiments do not reproduce the connection between early and late winter as interpreted from the reanalysis. Potentially explaining this mismatch, we identify a discrepancy of ECHAM6 to reproduce the weakening of the stratospheric polar vortex through blocking induced upward propagation of planetary waves.}, language = {en} } @article{GerlachGlueckKunze2023, author = {Gerlach, Moritz and Gl{\"u}ck, Jochen and Kunze, Markus}, title = {Stability of transition semigroups and applications to parabolic equations}, series = {Transactions of the American Mathematical Society}, volume = {376}, journal = {Transactions of the American Mathematical Society}, number = {1}, publisher = {American Mathematical Soc.}, address = {Providence}, issn = {0002-9947}, doi = {10.1090/tran/8620}, pages = {153 -- 180}, year = {2023}, abstract = {This paper deals with the long-term behavior of positive operator semigroups on spaces of bounded functions and of signed measures, which have applications to parabolic equations with unbounded coefficients and to stochas-tic analysis. The main results are a Tauberian type theorem characterizing the convergence to equilibrium of strongly Feller semigroups and a generalization of a classical convergence theorem of Doob. None of these results requires any kind of time regularity of the semigroup.}, language = {en} } @article{SchwetlickBackhausEngbert2023, author = {Schwetlick, Lisa and Backhaus, Daniel and Engbert, Ralf}, title = {A dynamical scan-path model for task-dependence during scene viewing}, series = {Psychological review}, volume = {130}, journal = {Psychological review}, number = {3}, publisher = {American Psychological Association}, address = {Washington}, issn = {0033-295X}, doi = {10.1037/rev0000379}, pages = {807 -- 840}, year = {2023}, abstract = {In real-world scene perception, human observers generate sequences of fixations to move image patches into the high-acuity center of the visual field. Models of visual attention developed over the last 25 years aim to predict two-dimensional probabilities of gaze positions for a given image via saliency maps. Recently, progress has been made on models for the generation of scan paths under the constraints of saliency as well as attentional and oculomotor restrictions. Experimental research demonstrated that task constraints can have a strong impact on viewing behavior. Here, we propose a scan-path model for both fixation positions and fixation durations, which include influences of task instructions and interindividual differences. Based on an eye-movement experiment with four different task conditions, we estimated model parameters for each individual observer and task condition using a fully Bayesian dynamical modeling framework using a joint spatial-temporal likelihood approach with sequential estimation. Resulting parameter values demonstrate that model properties such as the attentional span are adjusted to task requirements. Posterior predictive checks indicate that our dynamical model can reproduce task differences in scan-path statistics across individual observers.}, language = {en} } @article{BotteriPeveriBerstadetal.2022, author = {Botteri, Edoardo and Peveri, Giulia and Berstad, Paula and Bagnardi, Vincenzo and Chen, Sairah L. F. and Sandanger, Torkjel M. and Hoff, Geir and Dahm, Christina C. and Antoniussen, Christian S. and Tjonneland, Anne and Eriksen, Anne Kirstine and Skeie, Guri and Perez-Cornago, Aurora and Huerta, Jose Maria and Jakszyn, Paula and Harlid, Sophia and Sundstroem, Bjoern and Barricarte, Aurelio and Monninkhof, Evelyn M. and Derksen, Jeroen W. G. and Schulze, Matthias Bernd and Bueno-de-Mesquita, Bas and Sanchez, Maria-Jose and Cross, Amanda J. and Tsilidis, Konstantinos K. and De Magistris, Maria Santucci and Kaaks, Rudolf and Katzke, Verena and Rothwell, Joseph A. and Laouali, Nasser and Severi, Gianluca and Amiano, Pilar and Contiero, Paolo and Sacerdote, Carlotta and Goldberg, Marcel and Touvier, Mathilde and Freisling, Heinz and Viallon, Vivian and Weiderpass, Elisabete and Riboli, Elio and Gunter, Marc J. and Jenab, Mazda and Ferrari, Pietro}, title = {Changes in lifestyle and risk of colorectal cancer in the European prospective investigation into cancer and nutrition}, series = {The American journal of gastroenterology : AJG}, volume = {118}, journal = {The American journal of gastroenterology : AJG}, number = {4}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0002-9270}, doi = {10.14309/ajg.0000000000002065}, pages = {702 -- 711}, year = {2022}, abstract = {INTRODUCTION: We investigated the impact of changes in lifestyle habits on colorectal cancer (CRC) risk in a multicountry European cohort. METHODS: We used baseline and follow-up questionnaire data from the European Prospective Investigation into Cancer cohort to assess changes in lifestyle habits and their associations with CRC development. We calculated a healthy lifestyle index (HLI) score based on smoking status, alcohol consumption, body mass index, and physical activity collected at the 2 time points. HLI ranged from 0 (most unfavorable) to 16 (most favorable). We estimated the association between HLI changes and CRC risk using Cox regression models and reported hazard ratios (HR) with 95\% confidence intervals (CI). RESULTS: Among 295,865 participants, 2,799 CRC cases were observed over a median of 7.8 years. The median time between questionnaires was 5.7 years. Each unit increase in HLI from the baseline to the follow-up assessment was associated with a statistically significant 3\% lower CRC risk. Among participants in the top tertile at baseline (HLI > 11), those in the bottom tertile at follow-up (HLI <= 9) had a higher CRC risk (HR 1.34; 95\% CI 1.02-1.75) than those remaining in the top tertile. Among individuals in the bottom tertile at baseline, those in the top tertile at follow-up had a lower risk (HR 0.77; 95\% CI 0.59-1.00) than those remaining in the bottom tertile. DISCUSSION: Improving adherence to a healthy lifestyle was inversely associated with CRC risk, while worsening adherence was positively associated with CRC risk. These results justify and support recommendations for healthy lifestyle changes and healthy lifestyle maintenance for CRC prevention.}, language = {en} } @article{DiBelloHartmannMajumdaretal.2023, author = {Di Bello, Costantino and Hartmann, Alexander K. and Majumdar, Satya N. and Mori, Francesco and Rosso, Alberto and Schehr, Gregory}, title = {Current fluctuations in stochastically resetting particle systems}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {108}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {1}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.108.014112}, pages = {18}, year = {2023}, abstract = {We consider a system of noninteracting particles on a line with initial positions distributed uniformly with density ? on the negative half-line. We consider two different models: (i) Each particle performs independent Brownian motion with stochastic resetting to its initial position with rate r and (ii) each particle performs run -and-tumble motion, and with rate r its position gets reset to its initial value and simultaneously its velocity gets randomized. We study the effects of resetting on the distribution P(Q, t) of the integrated particle current Q up to time t through the origin (from left to right). We study both the annealed and the quenched current distributions and in both cases, we find that resetting induces a stationary limiting distribution of the current at long times. However, we show that the approach to the stationary state of the current distribution in the annealed and the quenched cases are drastically different for both models. In the annealed case, the whole distribution P-an(Q, t) approaches its stationary limit uniformly for all Q. In contrast, the quenched distribution P-qu(Q, t) attains its stationary form for Q < Q(crit)(t), while it remains time dependent for Q > Q(crit)(t). We show that Q(crit)(t) increases linearly with t for large t. On the scale where Q <; Q(crit)(t), we show that P-qu(Q, t) has an unusual large deviation form with a rate function that has a third-order phase transition at the critical point. We have computed the associated rate functions analytically for both models. Using an importance sampling method that allows to probe probabilities as tiny as 10-14000, we were able to compute numerically this nonanalytic rate function for the resetting Brownian dynamics and found excellent agreement with our analytical prediction.}, language = {en} } @article{GrdseloffBouldayRoedeletal.2023, author = {Grdseloff, Nastasja and Boulday, Gwenola and Roedel, Claudia J. and Otten, Cecile and Vannier, Daphne Raphaelle and Cardoso, Cecile and Faurobert, Eva and Dogra, Deepika and Tournier-Lasserve, Elisabeth and Abdelilah-Seyfried, Salim}, title = {Impaired retinoic acid signaling in cerebral cavernous malformations}, series = {Scientific reports}, volume = {13}, journal = {Scientific reports}, number = {1}, publisher = {Nature Portfolio}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-023-31905-0}, pages = {11}, year = {2023}, abstract = {The capillary-venous pathology cerebral cavernous malformation (CCM) is caused by loss of CCM1/Krev interaction trapped protein 1 (KRIT1), CCM2/MGC4607, or CCM3/PDCD10 in some endothelial cells. Mutations of CCM genes within the brain vasculature can lead to recurrent cerebral hemorrhages. Pharmacological treatment options are urgently needed when lesions are located in deeply-seated and in-operable regions of the central nervous system. Previous pharmacological suppression screens in disease models of CCM led to the discovery that treatment with retinoic acid improved CCM phenotypes. This finding raised a need to investigate the involvement of retinoic acid in CCM and test whether it has a curative effect in preclinical mouse models. Here, we show that components of the retinoic acid synthesis and degradation pathway are transcriptionally misregulated across disease models of CCM. We complemented this analysis by pharmacologically modifying retinoic acid levels in zebrafish and human endothelial cell models of CCM, and in acute and chronic mouse models of CCM. Our pharmacological intervention studies in CCM2-depleted human umbilical vein endothelial cells (HUVECs) and krit1 mutant zebrafish showed positive effects when retinoic acid levels were increased. However, therapeutic approaches to prevent the development of vascular lesions in adult chronic murine models of CCM were drug regiment-sensitive, possibly due to adverse developmental effects of this hormone. A treatment with high doses of retinoic acid even worsened CCM lesions in an adult chronic murine model of CCM. This study provides evidence that retinoic acid signaling is impaired in the CCM pathophysiology and suggests that modification of retinoic acid levels can alleviate CCM phenotypes.}, language = {en} } @article{EhrigWagnerWolteretal.2023, author = {Ehrig, Lukas and Wagner, Ann-Christin and Wolter, Heike and Correll, Christoph U. and Geisel, Olga and Konigorski, Stefan}, title = {FASDetect as a machine learning-based screening app for FASD in youth with ADHD}, series = {npj Digital Medicine}, volume = {6}, journal = {npj Digital Medicine}, number = {1}, publisher = {Macmillan Publishers Limited}, address = {Basingstoke}, issn = {2398-6352}, doi = {10.1038/s41746-023-00864-1}, pages = {9}, year = {2023}, abstract = {Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a German University outpatient unit are assessed including 275 patients aged 0-19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0-19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance. Random forest models yield the best prediction models with a cross-validated AUC of 0.92 (95\% confidence interval [0.84, 0.99]). Follow-up analyses indicate that a random forest model with 6 variables - body length and head circumference at birth, IQ, socially intrusive behaviour, poor memory and sleep disturbance - yields equivalent predictive accuracy. We implement the prediction model in a web-based app called FASDetect - a user-friendly, clinically scalable FASD risk calculator that is freely available at https://fasdetect.dhc-lab.hpi.de.}, language = {en} } @article{SlosarekIbingSchormairetal.2023, author = {Slosarek, Tamara and Ibing, Susanne and Schormair, Barbara and Heyne, Henrike and B{\"o}ttinger, Erwin and Andlauer, Till and Schurmann, Claudia}, title = {Implementation and evaluation of personal genetic testing as part of genomics analysis courses in German universities}, series = {BMC Medical Genomics}, volume = {16}, journal = {BMC Medical Genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1755-8794}, doi = {10.1186/s12920-023-01503-0}, pages = {13}, year = {2023}, abstract = {Purpose Due to the increasing application of genome analysis and interpretation in medical disciplines, professionals require adequate education. Here, we present the implementation of personal genotyping as an educational tool in two genomics courses targeting Digital Health students at the Hasso Plattner Institute (HPI) and medical students at the Technical University of Munich (TUM). Methods We compared and evaluated the courses and the students ' perceptions on the course setup using questionnaires. Results During the course, students changed their attitudes towards genotyping (HPI: 79\% [15 of 19], TUM: 47\% [25 of 53]). Predominantly, students became more critical of personal genotyping (HPI: 73\% [11 of 15], TUM: 72\% [18 of 25]) and most students stated that genetic analyses should not be allowed without genetic counseling (HPI: 79\% [15 of 19], TUM: 70\% [37 of 53]). Students found the personal genotyping component useful (HPI: 89\% [17 of 19], TUM: 92\% [49 of 53]) and recommended its inclusion in future courses (HPI: 95\% [18 of 19], TUM: 98\% [52 of 53]). Conclusion Students perceived the personal genotyping component as valuable in the described genomics courses. The implementation described here can serve as an example for future courses in Europe.}, language = {en} } @article{ToumoulinTardifBecquetDonnadieuetal.2022, author = {Toumoulin, Agathe and Tardif-Becquet, Delphine and Donnadieu, Yannick and Licht, Alexis and Ladant, Jean-Baptiste and Kunzmann, Lutz and Dupont-Nivet, Guillaume}, title = {Evolution of continental temperature seasonality from the Eocene greenhouse to the Oligocene icehouse}, series = {Climate of the past : an interactive open access journal of the European Geosciences Union}, volume = {18}, journal = {Climate of the past : an interactive open access journal of the European Geosciences Union}, number = {2}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1814-9324}, doi = {10.5194/cp-18-341-2022}, pages = {341 -- 362}, year = {2022}, abstract = {At the junction of greenhouse and icehouse climate states, the Eocene-Oligocene Transition (EOT) is a key moment in Cenozoic climate history. While it is associated with severe extinctions and biodiversity turnovers on land, the role of terrestrial climate evolution remains poorly resolved, especially the associated changes in seasonality. Some paleobotanical and geochemical continental records in parts of the Northern Hemisphere suggest the EOT is associated with a marked cooling in winter, leading to the development of more pronounced seasons (i.e., an increase in the mean annual range of temperature, MATR). However, the MATR increase has been barely studied by climate models and large uncertainties remain on its origin, geographical extent and impact. In order to better understand and describe temperature seasonality changes between the middle Eocene and the early Oligocene, we use the Earth system model IPSL-CM5A2 and a set of simulations reconstructing the EOT through three major climate forcings: pCO(2) decrease (1120, 840 and 560 ppm), the Antarctic ice-sheet (AIS) formation and the associated sea-level decrease. Our simulations suggest that pCO(2) lowering alone is not sufficient to explain the seasonality evolution described by the data through the EOT but rather that the combined effects of pCO(2) , AIS formation and increased continentality provide the best data-model agreement.pCO(2) decrease induces a zonal pattern with alternating increasing and decreasing seasonality bands particularly strong in the northern high latitudes (up to 8 degrees C MATR increase) due to sea-ice and surface albedo feedback. Conversely, the onset of the AIS is responsible for a more constant surface albedo yearly, which leads to a strong decrease in seasonality in the southern midlatitudes to high latitudes (> 40 degrees S). Finally, continental areas that emerged due to the sea-level lowering cause the largest increase in seasonality and explain most of the global heterogeneity in MATR changes (1MATR) patterns. The Delta MATR patterns we reconstruct are generally consistent with the variability of the EOT biotic crisis intensity across the Northern Hemisphere and provide insights on their underlying mechanisms.}, language = {en} } @article{SchwopePiresKurpasetal.2022, author = {Schwope, Axel and Pires, Adriana M. and Kurpas, Jan and Doroshenko, Victor and Suleimanov, Valery F. and Freyberg, Michael and Becker, Werner and Dennerl, Konrad and Haberl, Frank and Lamer, Georg and Maitra, Chandreyee and Potekhin, Alexander Y. and Ramos-Ceja, Miriam E. and Santangelo, Andrea and Traulsen, Iris and Werner, Klaus}, title = {Phase-resolved X-ray spectroscopy of PSR B0656+14 with SRG/eROSITA and XMM-Newton}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {661}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/202141105}, pages = {21}, year = {2022}, abstract = {We present a detailed spectroscopic and timing analysis of X-ray observations of the bright pulsar PSR B0656+14. The observations were obtained simultaneously with eROSITA and XMM-Newton during the calibration and performance verification phase of the Spektrum-Roentgen-Gamma mission (SRG). The analysis of the 100 ks deep observation of eROSITA is supported by archival observations of the source, including XMM-Newton, NuSTAR, and NICER. Using XMM-Newton and NICER, we first established an X-ray ephemeris for the time interval 2015 to 2020, which connects all X-ray observations in this period without cycle count alias and phase shifts. The mean eROSITA spectrum clearly reveals an absorption feature originating from the star at 570 eV with a Gaussian sigma of about 70 eV that was tentatively identified in a previous long XMM-Newton observation. A second previously discussed absorption feature occurs at 260-265 eV and is described here as an absorption edge. It could be of atmospheric or of instrumental origin. These absorption features are superposed on various emission components that are phenomenologically described here as the sum of hot (120 eV) and cold (65 eV) blackbody components, both of photospheric origin, and a power law with photon index Gamma = 2 from the magnetosphere. We created energy-dependent light curves and phase-resolved spectra with a high signal-to-noise ratio. The phase-resolved spectroscopy reveals that the Gaussian absorption line at 570 eV is clearly present throughout similar to 60\% of the spin cycle, but it is otherwise undetected. Likewise, its parameters were found to be dependent on phase. The visibility of the line strength coincides in phase with the maximum flux of the hot blackbody. If the line originates from the stellar surface, it nevertheless likely originates from a different location than the hot polar cap. We also present three families of model atmospheres: a magnetized atmosphere, a condensed surface, and a mixed model. They were applied to the mean observed spectrum, whose continuum fit the observed data well. The atmosphere model, however, predicts distances that are too short. For the mixed model, the Gaussian absorption may be interpreted as proton cyclotron absorption in a field as high as 10(14) G, which is significantly higher than the field derived from the moderate observed spin-down.}, language = {en} } @book{Schulte2023, author = {Schulte, Christoph}, title = {Zimzum}, publisher = {University of Pennsylvania Press}, address = {Philadelphia}, isbn = {978-1-5128-2436-0}, doi = {10.9783/9781512824360}, pages = {424}, year = {2023}, abstract = {Zimzum is the kabbalistic idea that God created the world by limiting his omnipresence. Zimzum originated in the teachings of the sixteenth-century Jewish mystic Isaac Luria and here, Christoph Schulte follows its traces across the Jewish and Christian intellectual history of Europe and North America over four centuries. The Hebrew word zimzum originally means "contraction," "withdrawal," "retreat," "limitation," and "concentration." In Kabbalah, zimzum is a term for God's self-limitation, done before creating the world to create the world. Jewish mystic Isaac Luria coined this term in Galilee in the sixteenth century, positing that the God who was "Ein-Sof," unlimited and omnipresent before creation, must concentrate himself in the zimzum and withdraw in order to make room for the creation of the world in God's own center. At the same time, God also limits his infinite omnipotence to allow the finite world to arise. Without the zimzum there is no creation, making zimzum one of the basic concepts of Judaism. The Lurianic doctrine of the zimzum has been considered an intellectual showpiece of the Kabbalah and of Jewish philosophy. The teaching of the zimzum has appeared in the Kabbalistic literature across Central and Eastern Europe, perhaps most famously in Hasidic literature up to the present day and in philosopher and historian Gershom Scholem's epoch-making research on Jewish mysticism. The Zimzum has fascinated Jewish and Christian theologians, philosophers, and writers like no other Kabbalistic teaching. This can be seen across the philosophy and cultural history of the twentieth century as it gained prominence among such diverse authors and artists as Franz Rosenzweig, Hans Jonas, Isaac Bashevis Singer, Harold Bloom, Barnett Newman, and Anselm Kiefer. This book follows the traces of the zimzum across the Jewish and Christian intellectual history of Europe and North America over more than four centuries, where Judaism and Christianity, theosophy and philosophy, divine and human, mysticism and literature, Kabbalah and the arts encounter, mix, and cross-fertilize the interpretations and appropriations of this doctrine of God's self-entanglement and limitation.}, language = {en} } @article{FalkenhagenKnoechelKloftetal.2023, author = {Falkenhagen, Undine and Kn{\"o}chel, Jane and Kloft, Charlotte and Huisinga, Wilhelm}, title = {Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models}, series = {CPT: Pharmacometrics \& Systems Pharmacology}, volume = {12}, journal = {CPT: Pharmacometrics \& Systems Pharmacology}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {2163-8306}, doi = {10.1002/psp4.12903}, pages = {432 -- 443}, year = {2023}, abstract = {Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to derive simpler, mechanism-based pharmacodynamic (PD) models. Their complexity, however, is typically still too large to be used in the population analysis of clinical data. Here, we extend the approach beyond state reduction to also include the simplification of reaction rates, elimination of reactions, and analytic solutions. We additionally ensure that the reduced model maintains a prespecified approximation quality not only for a reference individual but also for a diverse virtual population. We illustrate the extended approach for the warfarin effect on blood coagulation. Using the model-reduction approach, we derive a novel small-scale warfarin/international normalized ratio model and demonstrate its suitability for biomarker identification. Due to the systematic nature of the approach in comparison with empirical model building, the proposed model-reduction algorithm provides an improved rationale to build PD models also from QSP models in other applications.}, language = {en} } @phdthesis{Taleb2024, author = {Taleb, Aiham}, title = {Self-supervised deep learning methods for medical image analysis}, doi = {10.25932/publishup-64408}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-644089}, school = {Universit{\"a}t Potsdam}, pages = {xii, 171}, year = {2024}, abstract = {Deep learning has seen widespread application in many domains, mainly for its ability to learn data representations from raw input data. Nevertheless, its success has so far been coupled with the availability of large annotated (labelled) datasets. This is a requirement that is difficult to fulfil in several domains, such as in medical imaging. Annotation costs form a barrier in extending deep learning to clinically-relevant use cases. The labels associated with medical images are scarce, since the generation of expert annotations of multimodal patient data at scale is non-trivial, expensive, and time-consuming. This substantiates the need for algorithms that learn from the increasing amounts of unlabeled data. Self-supervised representation learning algorithms offer a pertinent solution, as they allow solving real-world (downstream) deep learning tasks with fewer annotations. Self-supervised approaches leverage unlabeled samples to acquire generic features about different concepts, enabling annotation-efficient downstream task solving subsequently. Nevertheless, medical images present multiple unique and inherent challenges for existing self-supervised learning approaches, which we seek to address in this thesis: (i) medical images are multimodal, and their multiple modalities are heterogeneous in nature and imbalanced in quantities, e.g. MRI and CT; (ii) medical scans are multi-dimensional, often in 3D instead of 2D; (iii) disease patterns in medical scans are numerous and their incidence exhibits a long-tail distribution, so it is oftentimes essential to fuse knowledge from different data modalities, e.g. genomics or clinical data, to capture disease traits more comprehensively; (iv) Medical scans usually exhibit more uniform color density distributions, e.g. in dental X-Rays, than natural images. Our proposed self-supervised methods meet these challenges, besides significantly reducing the amounts of required annotations. We evaluate our self-supervised methods on a wide array of medical imaging applications and tasks. Our experimental results demonstrate the obtained gains in both annotation-efficiency and performance; our proposed methods outperform many approaches from related literature. Additionally, in case of fusion with genetic modalities, our methods also allow for cross-modal interpretability. In this thesis, not only we show that self-supervised learning is capable of mitigating manual annotation costs, but also our proposed solutions demonstrate how to better utilize it in the medical imaging domain. Progress in self-supervised learning has the potential to extend deep learning algorithms application to clinical scenarios.}, language = {en} } @phdthesis{Khosravi2023, author = {Khosravi, Sara}, title = {The effect of new turbulence parameterizations for the stable surface layer on simulations of the Arctic climate}, doi = {10.25932/publishup-64352}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-643520}, school = {Universit{\"a}t Potsdam}, pages = {XIV, 119}, year = {2023}, abstract = {Arctic climate change is marked by intensified warming compared to global trends and a significant reduction in Arctic sea ice which can intricately influence mid-latitude atmospheric circulation through tropo- and stratospheric pathways. Achieving accurate simulations of current and future climate demands a realistic representation of Arctic climate processes in numerical climate models, which remains challenging. Model deficiencies in replicating observed Arctic climate processes often arise due to inadequacies in representing turbulent boundary layer interactions that determine the interactions between the atmosphere, sea ice, and ocean. Many current climate models rely on parameterizations developed for mid-latitude conditions to handle Arctic turbulent boundary layer processes. This thesis focuses on modified representation of the Arctic atmospheric processes and understanding their resulting impact on large-scale mid-latitude atmospheric circulation within climate models. The improved turbulence parameterizations, recently developed based on Arctic measurements, were implemented in the global atmospheric circulation model ECHAM6. This involved modifying the stability functions over sea ice and ocean for stable stratification and changing the roughness length over sea ice for all stratification conditions. Comprehensive analyses are conducted to assess the impacts of these modifications on ECHAM6's simulations of the Arctic boundary layer, overall atmospheric circulation, and the dynamical pathways between the Arctic and mid-latitudes. Through a step-wise implementation of the mentioned parameterizations into ECHAM6, a series of sensitivity experiments revealed that the combined impacts of the reduced roughness length and the modified stability functions are non-linear. Nevertheless, it is evident that both modifications consistently lead to a general decrease in the heat transfer coefficient, being in close agreement with the observations. Additionally, compared to the reference observations, the ECHAM6 model falls short in accurately representing unstable and strongly stable conditions. The less frequent occurrence of strong stability restricts the influence of the modified stability functions by reducing the affected sample size. However, when focusing solely on the specific instances of a strongly stable atmosphere, the sensible heat flux approaches near-zero values, which is in line with the observations. Models employing commonly used surface turbulence parameterizations were shown to have difficulties replicating the near-zero sensible heat flux in strongly stable stratification. I also found that these limited changes in surface layer turbulence parameterizations have a statistically significant impact on the temperature and wind patterns across multiple pressure levels, including the stratosphere, in both the Arctic and mid-latitudes. These significant signals vary in strength, extent, and direction depending on the specific month or year, indicating a strong reliance on the background state. Furthermore, this research investigates how the modified surface turbulence parameterizations may influence the response of both stratospheric and tropospheric circulation to Arctic sea ice loss. The most suitable parameterizations for accurately representing Arctic boundary layer turbulence were identified from the sensitivity experiments. Subsequently, the model's response to sea ice loss is evaluated through extended ECHAM6 simulations with different prescribed sea ice conditions. The simulation with adjusted surface turbulence parameterizations better reproduced the observed Arctic tropospheric warming in vertical extent, demonstrating improved alignment with the reanalysis data. Additionally, unlike the control experiments, this simulation successfully reproduced specific circulation patterns linked to the stratospheric pathway for Arctic-mid-latitude linkages. Specifically, an increased occurrence of the Scandinavian-Ural blocking regime (negative phase of the North Atlantic Oscillation) in early (late) winter is observed. Overall, it can be inferred that improving turbulence parameterizations at the surface layer can improve the ECHAM6's response to sea ice loss.}, language = {en} } @article{SmithBoers2023, author = {Smith, Taylor and Boers, Niklas}, title = {Global vegetation resilience linked to water availability and variability}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-36207-7}, pages = {11}, year = {2023}, abstract = {Quantifying the resilience of vegetated ecosystems is key to constraining both present-day and future global impacts of anthropogenic climate change. Here we apply both empirical and theoretical resilience metrics to remotely-sensed vegetation data in order to examine the role of water availability and variability in controlling vegetation resilience at the global scale. We find a concise global relationship where vegetation resilience is greater in regions with higher water availability. We also reveal that resilience is lower in regions with more pronounced inter-annual precipitation variability, but find less concise relationships between vegetation resilience and intra-annual precipitation variability. Our results thus imply that the resilience of vegetation responds differently to water deficits at varying time scales. In view of projected increases in precipitation variability, our findings highlight the risk of ecosystem degradation under ongoing climate change. Vegetation dynamics depend on both the amount of precipitation and its variability over time. Here, the authors show that vegetation resilience is greater where water availability is higher and where precipitation is more stable from year to year.}, language = {en} } @article{deCarvalhoSouzaBarrocasFischeretal.2023, author = {de Carvalho Souza, Alyson Matheus and Barrocas, Roberta and Fischer, Martin H. and Arnaud, Emanuel and Moeller, Korbinian and Renn{\´o}-Costa, C{\´e}sar}, title = {Combining virtual reality and tactile stimulation to investigate embodied finger-based numerical representations}, series = {Frontiers in psychology / Frontiers Research Foundation}, volume = {14}, journal = {Frontiers in psychology / Frontiers Research Foundation}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2023.1119561}, pages = {13}, year = {2023}, abstract = {Finger-based representation of numbers is a high-level cognitive strategy to assist numerical and arithmetic processing in children and adults. It is unclear whether this paradigm builds on simple perceptual features or comprises several attributes through embodiment. Here we describe the development and initial testing of an experimental setup to study embodiment during a finger-based numerical task using Virtual Reality (VR) and a low-cost tactile stimulator that is easy to build. Using VR allows us to create new ways to study finger-based numerical representation using a virtual hand that can be manipulated in ways our hand cannot, such as decoupling tactile and visual stimuli. The goal is to present a new methodology that can allow researchers to study embodiment through this new approach, maybe shedding new light on the cognitive strategy behind the finger-based representation of numbers. In this case, a critical methodological requirement is delivering precisely targeted sensory stimuli to specific effectors while simultaneously recording their behavior and engaging the participant in a simulated experience. We tested the device's capability by stimulating users in different experimental configurations. Results indicate that our device delivers reliable tactile stimulation to all fingers of a participant's hand without losing motion tracking quality during an ongoing task. This is reflected by an accuracy of over 95\% in participants detecting stimulation of a single finger or multiple fingers in sequential stimulation as indicated by experiments with sixteen participants. We discuss possible application scenarios, explain how to apply our methodology to study the embodiment of finger-based numerical representations and other high-level cognitive functions, and discuss potential further developments of the device based on the data obtained in our testing.}, language = {en} } @article{Philipowski2021, author = {Philipowski, Katharina}, title = {Experience and poetology in allegorical love autobiographies}, series = {Medieval Forms of First-Person Narration: A Potentially Universal Format (Villa Vigoni Talks I)}, volume = {8}, journal = {Medieval Forms of First-Person Narration: A Potentially Universal Format (Villa Vigoni Talks I)}, number = {Special Issue}, editor = {Philipowski, Katharina}, publisher = {University of Oldenburg Press}, address = {Oldenburg}, issn = {2568-9967}, doi = {10.25619/BmE_H202038}, url = {http://nbn-resolving.de/https://ojs.uni-oldenburg.de/ojs/index.php/bme/article/view/75/136}, pages = {1 -- 27}, year = {2021}, abstract = {Im Hochmittelalter entstehen Erz{\"a}hlungen, die etablierte literarische Formen und Traditionen neu verbinden: Sie sind volkssprachig, allegorisch und verwenden als Erz{\"a}hlform die erste Person, um in dieser Kombination, die sich zu einem die Grenzen der Einzelsprachen {\"u}berschreitenden Erz{\"a}hl-Format verfestigt, unterschiedlichste Themen aufzugreifen. Dieses Format, erstmals realisiert im altfranz{\"o}sischen Roman de la Rose, wird die europ{\"a}ische Literatur mit Texten wie Dantes Divina Comedia, Guillaumes de Deguileville P{\`e}lerinage de la Vie Humaine, William Langlands Pierce Plowman und Christines de Pizan Le Livre de la mutation de Fortune bis weit in die Neuzeit hinein pr{\"a}gen. Der in den Band einleitende Beitrag geht der Frage nach, ob das narrative Format dabei universell verwendet wird oder, z.B. im Rahmen der Liebesdichtung, spezifische Besonderheiten aufweist.}, language = {en} } @article{WarbyZuZeiskeetal.2022, author = {Warby, Jonathan and Zu, Fengshuo and Zeiske, Stefan and Gutierrez-Partida, Emilio and Frohloff, Lennart and Kahmann, Simon and Frohna, Kyle and Mosconi, Edoardo and Radicchi, Eros and Lang, Felix and Shah, Sahil and Pena-Camargo, Francisco and Hempel, Hannes and Unold, Thomas and Koch, Norbert and Armin, Ardalan and De Angelis, Filippo and Stranks, Samuel D. and Neher, Dieter and Stolterfoht, Martin}, title = {Understanding performance limiting interfacial recombination in pin Perovskite solar cells}, series = {Advanced energy materials}, volume = {12}, journal = {Advanced energy materials}, number = {12}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.202103567}, pages = {10}, year = {2022}, abstract = {Perovskite semiconductors are an attractive option to overcome the limitations of established silicon based photovoltaic (PV) technologies due to their exceptional opto-electronic properties and their successful integration into multijunction cells. However, the performance of single- and multijunction cells is largely limited by significant nonradiative recombination at the perovskite/organic electron transport layer junctions. In this work, the cause of interfacial recombination at the perovskite/C-60 interface is revealed via a combination of photoluminescence, photoelectron spectroscopy, and first-principle numerical simulations. It is found that the most significant contribution to the total C-60-induced recombination loss occurs within the first monolayer of C-60, rather than in the bulk of C-60 or at the perovskite surface. The experiments show that the C-60 molecules act as deep trap states when in direct contact with the perovskite. It is further demonstrated that by reducing the surface coverage of C-60, the radiative efficiency of the bare perovskite layer can be retained. The findings of this work pave the way toward overcoming one of the most critical remaining performance losses in perovskite solar cells.}, language = {en} } @article{HeistermannFranckeScheiffeleetal.2023, author = {Heistermann, Maik and Francke, Till and Scheiffele, Lena and Petrova, Katya Dimitrova and Budach, Christian and Schr{\"o}n, Martin and Trost, Benjamin and Rasche, Daniel and G{\"u}ntner, Andreas and Doepper, Veronika and F{\"o}rster, Michael and K{\"o}hli, Markus and Angermann, Lisa and Antonoglou, Nikolaos and Zude, Manuela and Oswald, Sascha}, title = {Three years of soil moisture observations by a dense cosmic-ray neutron sensing cluster at an agricultural research site in north-east Germany}, series = {Earth system science data : ESSD}, volume = {15}, journal = {Earth system science data : ESSD}, number = {7}, publisher = {Copernics Publications}, address = {Katlenburg-Lindau}, issn = {1866-3508}, doi = {10.5194/essd-15-3243-2023}, pages = {3243 -- 3262}, year = {2023}, abstract = {Cosmic-ray neutron sensing (CRNS) allows for the estimation of root-zone soil water content (SWC) at the scale of several hectares. In this paper, we present the data recorded by a dense CRNS network operated from 2019 to 2022 at an agricultural research site in Marquardt, Germany - the first multi-year CRNS cluster. Consisting, at its core, of eight permanently installed CRNS sensors, the cluster was supplemented by a wealth of complementary measurements: data from seven additional temporary CRNS sensors, partly co-located with the permanent ones; 27 SWC profiles (mostly permanent); two groundwater observation wells; meteorological records; and Global Navigation Satellite System reflectometry (GNSS-R). Complementary to these continuous measurements, numerous campaign-based activities provided data by mobile CRNS roving, hyperspectral im-agery via UASs, intensive manual sampling of soil properties (SWC, bulk density, organic matter, texture, soil hydraulic properties), and observations of biomass and snow (cover, depth, and density). The unique temporal coverage of 3 years entails a broad spectrum of hydro-meteorological conditions, including exceptional drought periods and extreme rainfall but also episodes of snow coverage, as well as a dedicated irrigation experiment. Apart from serving to advance CRNS-related retrieval methods, this data set is expected to be useful for vari-ous disciplines, for example, soil and groundwater hydrology, agriculture, or remote sensing. Hence, we show exemplary features of the data set in order to highlight the potential for such subsequent studies. The data are available at doi.org/10.23728/b2share.551095325d74431881185fba1eb09c95 (Heistermann et al., 2022b).}, language = {en} } @article{StueblerKloftHuisinga2023, author = {St{\"u}bler, Sabine and Kloft, Charlotte and Huisinga, Wilhelm}, title = {Cell-level systems biology model to study inflammatory bowel diseases and their treatment options}, series = {CPT: pharmacometrics \& systems pharmacology}, volume = {12}, journal = {CPT: pharmacometrics \& systems pharmacology}, number = {5}, publisher = {Nature Publ. Group}, address = {London}, issn = {2163-8306}, doi = {10.1002/psp4.12932}, pages = {690 -- 705}, year = {2023}, abstract = {To help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment modalities thereof. The model, including key cell types and processes of the mucosal immune response, compiles a large amount of isolated experimental findings from literature into a larger context and allows for simulations of different inflammation scenarios based on the underlying data and assumptions. In the context of a large and diverse virtual IBD population, we characterized the patients based on their phenotype (in contrast to healthy individuals, they developed persistent inflammation after a trigger event) rather than on a priori assumptions on parameter differences to a healthy individual. This allowed to reproduce the enormous diversity of predispositions known to lead to IBD. Analyzing different treatment effects, the model provides insight into characteristics of individual drug therapy. We illustrate for anti-TNF-alpha therapy, how the model can be used (i) to decide for alternative treatments with best prospects in the case of nonresponse, and (ii) to identify promising combination therapies with other available treatment options.}, language = {en} } @article{AgtheKayserSchwarzetal.2023, author = {Agthe, Maria and Kayser, Daniela Niesta and Schwarz, Sascha and Maner, Jon K.}, title = {Antecedents of the red-romance effect}, series = {PLOS ONE / Public Library of Science}, volume = {18}, journal = {PLOS ONE / Public Library of Science}, number = {4}, publisher = {PLOS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0284035}, pages = {19}, year = {2023}, abstract = {The color red has been implicated in a variety of social processes, including those involving mating. While previous research suggests that women sometimes wear red strategically to increase their attractiveness, the replicability of this literature has been questioned. The current research is a reasonably powered conceptual replication designed to strengthen this literature by testing whether women are more inclined to display the color red 1) during fertile (as compared with less fertile) days of the menstrual cycle, and 2) when expecting to interact with an attractive man (as compared with a less attractive man and with a control condition). Analyses controlled for a number of theoretically relevant covariates (relationship status, age, the current weather). Only the latter hypothesis received mixed support (mainly among women on hormonal birth control), whereas results concerning the former hypothesis did not reach significance. Women (N = 281) displayed more red when expecting to interact with an attractive man; findings did not support the prediction that women would increase their display of red on fertile days of the cycle. Findings thus suggested only mixed replicability for the link between the color red and psychological processes involving romantic attraction. They also illustrate the importance of further investigating the boundary conditions of color effects on everyday social processes.}, language = {en} } @article{SchmickerFruehlingMenzeetal.2023, author = {Schmicker, Marlen and Fr{\"u}hling, Insa and Menze, Inga and Glanz, Wenzel and M{\"u}ller, Patrick and Noesselt, Toemme and M{\"u}ller, Notger Germar}, title = {The potential role of gustatory function as an early diagnostic marker for the risk of alzheimer's disease in subjective cognitive decline}, series = {Journal of Alzheimer's disease reports : JADR}, volume = {7}, journal = {Journal of Alzheimer's disease reports : JADR}, number = {1}, publisher = {IOS Press}, address = {Clifton, VA}, issn = {2542-4823}, doi = {10.3233/ADR220092}, pages = {249 -- 262}, year = {2023}, abstract = {Background: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer's disease (AD) although psychophysical testing does not reveal any cognitive deficit. Objective: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. Methods: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD-) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin' Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. Results: Only taste was able to distinguish between HC/SCD- and SCD+ patients. Conclusion: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.}, language = {en} } @article{ShamsWangRoineetal.2022, author = {Shams, Boshra and Wang, Ziqian and Roine, Timo and Aydogan, Dogu Baran and Vajkoczy, Peter and Lippert, Christoph and Picht, Thomas and Fekonja, Lucius Samo}, title = {Machine learning-based prediction of motor status in glioma patients using diffusion MRI metrics along the corticospinal tract}, series = {Brain communications}, volume = {4}, journal = {Brain communications}, number = {3}, publisher = {Oxford University Press}, address = {Oxford}, issn = {2632-1297}, doi = {10.1093/braincomms/fcac141}, pages = {17}, year = {2022}, abstract = {Shams et al. report that glioma patients' motor status is predicted accurately by diffusion MRI metrics along the corticospinal tract based on support vector machine method, reaching an overall accuracy of 77\%. They show that these metrics are more effective than demographic and clinical variables. Along tract statistics enables white matter characterization using various diffusion MRI metrics. These diffusion models reveal detailed insights into white matter microstructural changes with development, pathology and function. Here, we aim at assessing the clinical utility of diffusion MRI metrics along the corticospinal tract, investigating whether motor glioma patients can be classified with respect to their motor status. We retrospectively included 116 brain tumour patients suffering from either left or right supratentorial, unilateral World Health Organization Grades II, III and IV gliomas with a mean age of 53.51 +/- 16.32 years. Around 37\% of patients presented with preoperative motor function deficits according to the Medical Research Council scale. At group level comparison, the highest non-overlapping diffusion MRI differences were detected in the superior portion of the tracts' profiles. Fractional anisotropy and fibre density decrease, apparent diffusion coefficient axial diffusivity and radial diffusivity increase. To predict motor deficits, we developed a method based on a support vector machine using histogram-based features of diffusion MRI tract profiles (e.g. mean, standard deviation, kurtosis and skewness), following a recursive feature elimination method. Our model achieved high performance (74\% sensitivity, 75\% specificity, 74\% overall accuracy and 77\% area under the curve). We found that apparent diffusion coefficient, fractional anisotropy and radial diffusivity contributed more than other features to the model. Incorporating the patient demographics and clinical features such as age, tumour World Health Organization grade, tumour location, gender and resting motor threshold did not affect the model's performance, revealing that these features were not as effective as microstructural measures. These results shed light on the potential patterns of tumour-related microstructural white matter changes in the prediction of functional deficits.}, language = {en} } @article{RepaschScheingrossHoviusetal.2022, author = {Repasch, Marisa and Scheingross, Joel S. and Hovius, Niels and Vieth-Hillebrand, Andrea and Mueller, Carsten W. and H{\"o}schen, Carmen and Szupiany, Ricardo N. and Sachse, Dirk}, title = {River organic carbon fluxes modulated by hydrodynamic sorting of particulate organic matter}, series = {Geophysical research letters}, volume = {49}, journal = {Geophysical research letters}, number = {3}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1029/2021GL096343}, pages = {11}, year = {2022}, abstract = {Rivers regulate the global carbon cycle by transferring particulate organic carbon (POC) from terrestrial landscapes to marine sedimentary basins, but the processes controlling the amount and composition of fluvially exported POC are poorly understood. We propose that hydrodynamic sorting processes modify POC fluxes during fluvial transit. We test this hypothesis by studying POC transported along a similar to 1,200 km reach of the Rio Bermejo, Argentina. Nanoscale secondary ion mass spectrometry revealed that POC was either fine, mineral-associated organic matter, or coarse discrete organic particles. Mineral-associated POC is more resistant to oxidation and has a lower particle settling velocity than discrete POC. Consequently, hydraulic sorting and downstream fining amplify the proportion of fine, mineral-associated POC from similar to 55\% to similar to 78\% over 1,220 km of downstream transit. This suggests that mineral-associated POC has a greater probability of export and preservation in marine basins than plant detritus, which may be oxidized to CO2 during transit.}, language = {en} } @article{SeboldChenOenaletal.2022, author = {Sebold, Miriam and Chen, Hao and {\"O}nal, Aleyna and Kuitunen-Paul, S{\"o}ren and Mojtahedzadeh, Negin and Garbusow, Maria and Nebe, Stephan and Wittchen, Hans-Ulrich and Huys, Quentin J. M. and Schlagenhauf, Florian and Rapp, Michael A. and Smolka, Michael N. and Heinz, Andreas}, title = {Stronger prejudices are associated with decreased model-based control}, series = {Frontiers in psychology}, volume = {12}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2021.767022}, pages = {10}, year = {2022}, abstract = {Background: Prejudices against minorities can be understood as habitually negative evaluations that are kept in spite of evidence to the contrary. Therefore, individuals with strong prejudices might be dominated by habitual or "automatic" reactions at the expense of more controlled reactions. Computational theories suggest individual differences in the balance between habitual/model-free and deliberative/model-based decision-making. Methods: 127 subjects performed the two Step task and completed the blatant and subtle prejudice scale. Results: By using analyses of choices and reaction times in combination with computational modeling, subjects with stronger blatant prejudices showed a shift away from model-based control. There was no association between these decision-making processes and subtle prejudices. Conclusion: These results support the idea that blatant prejudices toward minorities are related to a relative dominance of habitual decision-making. This finding has important implications for developing interventions that target to change prejudices across societies.}, language = {en} } @article{HerbstBaalmannBykovetal.2022, author = {Herbst, Konstantin and Baalmann, Lennart R. and Bykov, Andrei and Engelbrecht, N. Eugene and Ferreira, Stefan E. S. and Izmodenov, Vladislav V. and Korolkov, Sergey D. and Levenfish, Ksenia P. and Linsky, Jeffrey L. and Meyer, Dominique M. -A. and Scherer, Klaus and Strauss, R. Du Toit}, title = {Astrospheres of planet-hosting cool stars and beyond when modeling meets observations}, series = {Space science reviews}, volume = {218}, journal = {Space science reviews}, number = {4}, publisher = {Springer Nature}, address = {Dordrecht}, issn = {0038-6308}, doi = {10.1007/s11214-022-00894-3}, pages = {46}, year = {2022}, abstract = {Thanks to dedicated long-term missions like Voyager and GOES over the past 50 years, much insight has been gained on the activity of our Sun, the solar wind, its interaction with the interstellar medium, and, thus, about the formation, the evolution, and the structure of the heliosphere. Additionally, with the help of multi-wavelength observations by the Hubble Space Telescope, Kepler, and TESS, we not only were able to detect a variety of extrasolar planets and exomoons but also to study the characteristics of their host stars, and thus became aware that other stars drive bow shocks and astrospheres. Although features like, e.g., stellar winds, could not be measured directly, over the past years several techniques have been developed allowing us to indirectly derive properties like stellar mass-loss rates and stellar wind speeds, information that can be used as direct input to existing astrospheric modeling codes. In this review, the astrospheric modeling efforts of various stars will be presented. Starting with the heliosphere as a benchmark of astrospheric studies, investigating the paleo-heliospheric changes and the Balmer H alpha projections to 1 pc, we investigate the surroundings of cool and hot stars, but also of more exotic objects like neutron stars. While pulsar wind nebulae (PWNs) might be a source of high-energy galactic cosmic rays (GCRs), the astrospheric environments of cool and hot stars form a natural shield against GCRs. Their modulation within these astrospheres, and the possible impact of turbulence, are also addressed. This review shows that all of the presented modeling efforts are in excellent agreement with currently available observations.}, language = {en} } @article{XiongDelicZengetal.2022, author = {Xiong, Yingquan and Delic, Denis and Zeng, Shufei and Chen, Xin and Chu, Chang and Hasan, Ahmed A. and Kr{\"a}mer, Bernhard K. and Klein, Thomas and Yin, Lianghong and Hocher, Berthold}, title = {Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy-effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker}, series = {BMC nephrology}, volume = {23}, journal = {BMC nephrology}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {1471-2369}, doi = {10.1186/s12882-022-02747-1}, pages = {10}, year = {2022}, abstract = {Background Host factors such as angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease, serine-subtype-2 (TMPRSS2) are important factors for SARS-CoV-2 infection. Clinical and pre-clinical studies demonstrated that RAAS-blocking agents can be safely used during a SARS-CoV-2 infection but it is unknown if DPP-4 inhibitors or SGLT2-blockers may promote COVID-19 by increasing the host viral entry enzymes ACE2 and TMPRSS2. Methods We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model. In the present study, the gene expression of Ace2, Tmprss2, Ren, Agtr2 and Agt was assessed with qRT-PCR and the protein expression of ACE2 and TMPRSS2 with immunohistochemistry in the following experimental groups: Sham + normal diet (ND) + placebo (PBO); 5/6Nx + ND + PBO; 5/6Nx + high salt-diet (HSD) + PBO; 5/6Nx + HSD + telmisartan; 5/6Nx + HSD + linagliptin; 5/6Nx + HSD + empagliflozin. Results In the kidney, the expression of Ace2 was not altered on mRNA level under disease and treatment conditions. The renal TMPRSS2 levels (mRNA and protein) were not affected, whereas the cardiac level was significantly increased in 5/6Nx rats. Intriguingly, the elevated TMPRSS2 protein expression in the heart was significantly normalized after treatment with telmisartan, linagliptin and empagliflozin. Conclusions Our study indicated that there is no upregulation regarding host factors potentially promoting SARS-CoV-2 virus entry into host cells when the SGLT2-blocker empagliflozin, telmisartan and the DPP4-inhibitor blocker linagliptin are used. The results obtained in a preclinical, experimental non-diabetic kidney failure model need confirmation in ongoing interventional clinical trials.}, language = {en} } @article{VoglimacciStephanopoliWendlederLantuitetal.2022, author = {Voglimacci-Stephanopoli, Jo{\"e}lle and Wendleder, Anna and Lantuit, Hugues and Langlois, Alexandre and Stettner, Samuel and Schmitt, Andreas and Dedieu, Jean-Pierre and Roth, Achim and Royer, Alain}, title = {Potential of X-band polarimetric synthetic aperture radar co-polar phase difference for arctic snow depth estimation}, series = {Cryosphere}, volume = {16}, journal = {Cryosphere}, number = {6}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1994-0416}, doi = {10.5194/tc-16-2163-2022}, pages = {2163 -- 2181}, year = {2022}, abstract = {Changes in snowpack associated with climatic warming has drastic impacts on surface energy balance in the cryosphere. Yet, traditional monitoring techniques, such as punctual measurements in the field, do not cover the full snowpack spatial and temporal variability, which hampers efforts to upscale measurements to the global scale. This variability is one of the primary constraints in model development. In terms of spatial resolution, active microwaves (synthetic aperture radar - SAR) can address the issue and outperform methods based on passive microwaves. Thus, high-spatial-resolution monitoring of snow depth (SD) would allow for better parameterization of local processes that drive the spatial variability of snow. The overall objective of this study is to evaluate the potential of the TerraSAR-X (TSX) SAR sensor and the wave co-polar phase difference (CPD) method for characterizing snow cover at high spatial resolution. Consequently, we first (1) investigate SD and depth hoar fraction (DHF) variability between different vegetation classes in the Ice Creek catchment (Qikiqtaruk/Herschel Island, Yukon, Canada) using in situ measurements collected over the course of a field campaign in 2019; (2) evaluate linkages between snow characteristics and CPD distribution over the 2019 dataset; and (3) determine CPD seasonality considering meteorological data over the 2015-2019 period. SD could be extracted using the CPD when certain conditions are met. A high incidence angle (>30 circle) with a high topographic wetness index (TWI) (>7.0) showed correlation between SD and CPD (R2 up to 0.72). Further, future work should address a threshold of sensitivity to TWI and incidence angle to map snow depth in such environments and assess the potential of using interpolation tools to fill in gaps in SD information on drier vegetation types.}, language = {en} } @article{BuchmannFielitzSpiraetal.2022, author = {Buchmann, Nikolaus and Fielitz, Jens and Spira, Dominik and K{\"o}nig, Maximilian and Norman, Kristina and Pawelec, Graham and Goldeck, David and Demuth, Ilja and Steinhagen-Thiessen, Elisabeth}, title = {Muscle mass and inflammation in older adults: impact of the metabolic syndrome}, series = {Gerontology}, volume = {68}, journal = {Gerontology}, number = {9}, publisher = {Karger}, address = {Basel}, issn = {0304-324X}, doi = {10.1159/000520096}, pages = {989 -- 998}, year = {2022}, abstract = {Background: Inflammatory processes are a cause of accelerated loss of muscle mass. Metabolic syndrome (MetS) is a highly prevalent age-related condition, which may promote and be promoted by inflammation. However, whether inflammation in MetS (metaflammation) is associated with lower muscle mass is still unclear. Methods: Complete cross-sectional data on body composition, MetS, and the inflammatory markers interleukin (IL)-1 beta, IL-6, IL-10, tumor necrosis factor (TNF), and C-reactive protein (CRP) were available for 1,377 BASE-II participants (51.1\% women; 68 +/- 4 years old). Appendicular lean mass (ALM) was assessed by dual-energy X-ray absorptiometry. Low muscle mass (low ALM-to-BMI ratio [ALMBMI]) was defined according to the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. Regression models, adjusted for an increasing number of confounders (sex, age, physical activity, morbidities, diabetes mellitus type II, TSH, albumin, HbA1c, smoking habits, alcohol intake, education, and energy intake/day), were used to calculate the association between low ALMBMI and high inflammation (tertile 3) according to MetS. Results: MetS was present in 36.2\% of the study population, and 9\% had low ALMBMI. In the whole study population, high CRP (odds ratio [OR]: 2.7 [95\% CI: 1.6-4.7; p = 0.001]) and high IL-6 (OR: 2.1 [95\% CI: 1.2-1.9; p = 0.005]) were associated with low ALMBMI. In contrast, no significant association was found between TNF, IL-10, or IL-1 beta with low ALMBMI. When participants were stratified by MetS, results for IL-6 remained significant only in participants with MetS. Conclusions: Among BASE-II participants, low ALMBMI was associated with inflammation. Low-grade inflammation triggered by disease state, especially in the context of MetS, might favor loss of muscle mass, so a better control of MetS might help to prevent sarcopenia. Intervention studies to test whether strategies to prevent MetS might also prevent loss of muscle mass seem to be promising.}, language = {en} } @article{GalhuberMichenthalerHeiningeretal.2022, author = {Galhuber, Markus and Michenthaler, Helene and Heininger, Christoph and Reinisch, Isabel and N{\"o}ssing, Christoph and Krstic, Jelena and Kupper, Nadja and Moyschewitz, Elisabeth and Auer, Martina and Heitzer, Ellen and Ulz, Peter and Birner-Gruenberger, Ruth and Liesinger, Laura and Lenihan-Geels, Georgia Ngawai and Oster, Moritz and Spreitzer, Emil and Chiozzi, Riccardo Zenezini and Schulz, Tim J. and Schupp, Michael and Madl, Tobias and Heck, Albert J. R. and Prokesch, Andreas}, title = {Complementary omics strategies to dissect p53 signaling networks under nutrient stress}, series = {Cellular and molecular life sciences}, volume = {79}, journal = {Cellular and molecular life sciences}, number = {6}, publisher = {Springer Nature}, address = {Basel}, issn = {1420-682X}, doi = {10.1007/s00018-022-04345-8}, pages = {22}, year = {2022}, abstract = {Signaling trough p53is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human hepatoma cell line that starvation leads to robust nuclear p53 stabilization. Using BioID, we determine the cytoplasmic p53 interaction network within the immediate-early starvation response and show that p53 is dissociated from several metabolic enzymes and the kinase PAK2 for which direct binding with the p53 DNA-binding domain was confirmed with NMR studies. Furthermore, proteomics after p53 immunoprecipitation (RIME) uncovered the nuclear interactome under prolonged starvation, where we confirmed the novel p53 interactors SORBS1 (insulin receptor signaling) and UGP2 (glycogen synthesis). Finally, transcriptomics after p53 re-expression revealed a distinct starvation-specific transcriptome response and suggested previously unknown nutrient-dependent p53 target genes. Together, our complementary approaches delineate several nodes of the p53 signaling cascade upon starvation, shedding new light on the mechanisms of p53 as nutrient stress sensor. Given the central role of p53 in cancer biology and the beneficial effects of fasting in cancer treatment, the identified interaction partners and networks could pinpoint novel pharmacologic targets to fine-tune p53 activity.}, language = {en} } @article{OranWeissSantacruzPichetal.2022, author = {Oran, Rona and Weiss, Benjamin P. and Santacruz-Pich, Maria De Soria and Jun, Insoo and Lawrence, David J. and Polanskey, Carol A. and Ratliff, J. Martin and Raymond, Carol A. and Ream, Jodie B. and Russell, Christopher T. and Shprits, Yuri Y. and Zuber, Maria T. and Elkins-Tanton, Linda T.}, title = {Maximum energies of trapped particles around magnetized planets and small bodies}, series = {Geophysical research letters}, volume = {49}, journal = {Geophysical research letters}, number = {13}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1029/2021GL097014}, pages = {11}, year = {2022}, abstract = {Energetic charged particles trapped in planetary radiation belts are hazardous to spacecraft. Planned missions to iron-rich asteroids with possible strong remanent magnetic fields require an assessment of trapped particles energies. Using laboratory measurements of iron meteorites, we estimate the largest possible asteroid magnetic moment. Although weak compared to moments of planetary dynamos, the small body size may yield strong surface fields. We use hybrid simulations to confirm the formation of a magnetosphere with an extended quasi-dipolar region. However, the short length scale of the field implies that energetic particle motion would be nonadiabatic, making existing radiation belt theories not applicable. Our idealized particle simulations demonstrate that chaotic motions lead to particle loss at lower energies than those predicted by adiabatic theory, which may explain the energies of transiently trapped particles observed at Mercury, Ganymede, and Earth. However, even the most magnetized asteroids are unlikely to stably trap hazardous particles.}, language = {en} } @article{DhahbiChaabeneChaouachietal.2022, author = {Dhahbi, Wissem and Chaabene, Helmi and Chaouachi, Anis and Padulo, Johnny and Behm, David G. and Cochrane, Jodie and Burnett, Angus and Chamari, Karim}, title = {Kinetic analysis of push-up exercises: a systematic review with practical recommendations}, series = {Sports biomechanics}, volume = {21}, journal = {Sports biomechanics}, number = {1}, publisher = {Routledge}, address = {Abingdon}, issn = {1476-3141}, doi = {10.1080/14763141.2018.1512149}, pages = {1 -- 40}, year = {2022}, abstract = {Push-ups represent one of the simplest and most popular strengthening exercise. The aim of this study was to systematically review and critically appraise the literature on the kinetics-related characteristics of different types of push-ups, with the objective of optimising training prescription and exercise-related load. A systematic search was conducted in the electronic databases PubMed, Google Scholar and Science Direct up to April 2018. Studies that reported kinetic data (e.g. initial and peak-force supported by the upper-limbs, impact-force, peak-flexion-moment of the elbow-joint, rate of propulsive- and impact-, and vertebral-joint compressive-forces) related to push-ups and included trained, recreational and untrained participants, were considered. The risk of bias in the included studies was assessed using the Critical Appraisal Skills Programme scale. From 5290 articles retrieved in the initial search, only 26 studies were included in this review. Kinetic data for 46 push-up variants were assessed. A limitation of the current review is that the relationship between our findings and actual clinical or practical consequences is not statistically proven but can only be inferred from our critical descriptive approach. Overall, this review provides detailed data on specific characteristics and intensities of push-up variations, in order to optimise exercise prescription for training and rehabilitation purposes.}, language = {en} } @article{HerrmannBodenMaureretal.2022, author = {Herrmann, Matthias L. and Boden, Cindy and Maurer, Christoph and Kentischer, Felix and Mennig, Eva and Wagner, S{\"o}ren and Conzelmann, Lars O. and F{\"o}rstner, Bernd R. and Rapp, Michael A. and von Arnim, Christine A. F. and Denkinger, Michael and Eschweiler, Gerhard W. and Thomas, Christine}, title = {Anticholinergic drug exposure increases the risk of delirium in older patients undergoing elective surgery}, series = {Frontiers in medicine}, volume = {9}, journal = {Frontiers in medicine}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-858X}, doi = {10.3389/fmed.2022.871229}, pages = {8}, year = {2022}, abstract = {IntroductionPostoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful. Although preoperative medication intake is assumed to be an important modifiable risk factor, the impact of anticholinergic drugs on the occurrence of POD seems underestimated in elective surgery. The aim of this study was to investigate the association between preoperative anticholinergic burden and POD. We hypothesized that a high preoperative anticholinergic burden is an independent, potentially modifiable predisposing and precipitating factor of POD in older people. MethodsBetween November 2017 and April 2019, 1,470 patients of 70 years and older undergoing elective orthopedic, general, cardiac, or vascular surgery were recruited in the randomized, prospective, multicenter PAWEL trial. Anticholinergic burden of a sub-cohort of 899 patients, who did not receive a multimodal intervention for preventing POD, was assessed by two different tools at hospital admission: The established Anticholinergic Risk Scale (ARS) and the recently developed Anticholinergic Burden Score (ABS). POD was detected by confusion assessment method (CAM) and a validated post discharge medical record review. Logistic regression analyses were performed to evaluate the association between anticholinergic burden and POD. ResultsPOD was observed in 210 of 899 patients (23.4\%). Both ARS and ABS were independently associated with POD. The association persisted after adjustment for relevant confounding factors such as age, sex, comorbidities, preoperative cognitive and physical status, number of prescribed drugs, surgery time, type of surgery and anesthesia, usage of heart-lung-machine, and treatment in intensive care unit. If a patient was taking one of the 56 drugs listed in the ABS, risk for POD was 2.7-fold higher (OR = 2.74, 95\% CI = 1.55-4.94) and 1.5-fold higher per additional point on the ARS (OR = 1.54, 95\% CI = 1.15-2.02). ConclusionPreoperative anticholinergic drug exposure measured by ARS or ABS was independently associated with POD in older patients undergoing elective surgery. Therefore, identification, discontinuation or substitution of anticholinergic medication prior to surgery may be a promising approach to reduce the risk of POD in older patients.}, language = {en} } @article{HaugkJongejansMangelsdorfetal.2022, author = {Haugk, Charlotte and Jongejans, Loeka L. and Mangelsdorf, Kai and Fuchs, Matthias and Ogneva, Olga and Palmtag, Juri and Mollenhauer, Gesine and Mann, Paul J. and Overduin, P. Paul and Grosse, Guido and Sanders, Tina and Tuerena, Robyn E. and Schirrmeister, Lutz and Wetterich, Sebastian and Kizyakov, Alexander and Karger, Cornelia and Strauss, Jens}, title = {Organic matter characteristics of a rapidly eroding permafrost cliff in NE Siberia (Lena Delta, Laptev Sea region)}, series = {Biogeosciences}, volume = {19}, journal = {Biogeosciences}, number = {7}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-19-2079-2022}, pages = {2079 -- 2094}, year = {2022}, abstract = {Organic carbon (OC) stored in Arctic permafrost represents one of Earth's largest and most vulnerable terrestrial carbon pools. Amplified climate warming across the Arctic results in widespread permafrost thaw. Permafrost deposits exposed at river cliffs and coasts are particularly susceptible to thawing processes. Accelerating erosion of terrestrial permafrost along shorelines leads to increased transfer of organic matter (OM) to nearshore waters. However, the amount of terrestrial permafrost carbon and nitrogen as well as the OM quality in these deposits is still poorly quantified. We define the OM quality as the intrinsic potential for further transformation, decomposition and mineralisation. Here, we characterise the sources and the quality of OM supplied to the Lena River at a rapidly eroding permafrost river shoreline cliff in the eastern part of the delta (Sobo-Sise Island). Our multi-proxy approach captures bulk elemental, molecu- lar geochemical and carbon isotopic analyses of Late Pleistocene Yedoma permafrost and Holocene cover deposits, discontinuously spanning the last similar to 52 kyr. We showed that the ancient permafrost exposed in the Sobo-Sise cliff has a high organic carbon content (mean of about 5 wt \%). The oldest sediments stem from Marine Isotope Stage (MIS) 3 interstadial deposits (dated to 52 to 28 cal ka BP) and are overlaid by last glacial MIS 2 (dated to 28 to 15 cal ka BP) and Holocene MIS 1 (dated to 7-0 cal ka BP) deposits. The relatively high average chain length (ACL) index of n-alkanes along the cliff profile indicates a predominant contribution of vascular plants to the OM composition. The elevated ratio of isoand anteiso-branched fatty acids (FAs) relative to mid- and long-chain (C >= 20) n-FAs in the interstadial MIS 3 and the interglacial MIS 1 deposits suggests stronger microbial activity and consequently higher input of bacterial biomass during these climatically warmer periods. The overall high carbon preference index (CPI) and higher plant fatty acid (HPFA) values as well as high C/N ratios point to a good quality of the preserved OM and thus to a high potential of the OM for decomposition upon thaw. A decrease in HPFA values downwards along the profile probably indicates stronger OM decomposition in the oldest (MIS 3) deposits of the cliff. The characterisation of OM from eroding permafrost leads to a better assessment of the greenhouse gas potential of the OC released into river and nearshore waters in the future.}, language = {en} } @article{JaraMunozMelnickLietal.2022, author = {Jara-Mu{\~n}oz, Julius and Melnick, Daniel and Li, Shaoyang and Socquet, Anne and Cort{\´e}s-Aranda, Joaqu{\´i}n and Brill, Dominik and Strecker, Manfred R.}, title = {The cryptic seismic potential of the Pichilemu blind fault in Chile revealed by off-fault geomorphology}, series = {Nature communications}, volume = {13}, journal = {Nature communications}, number = {1}, publisher = {Nature Research}, address = {Berlin}, issn = {2041-1723}, doi = {10.1038/s41467-022-30754-1}, pages = {13}, year = {2022}, abstract = {The first step towards assessing hazards in seismically active regions involves mapping capable faults and estimating their recurrence times. While the mapping of active faults is commonly based on distinct geologic and geomorphic features evident at the surface, mapping blind seismogenic faults is complicated by the absence of on-fault diagnostic features. Here we investigated the Pichilemu Fault in coastal Chile, unknown until it generated a Mw 7.0 earthquake in 2010. The lack of evident surface faulting suggests activity along a partly-hidden blind fault. We used off-fault deformed marine terraces to estimate a fault-slip rate of 0.52 +/- 0.04 m/ka, which, when integrated with satellite geodesy suggests a 2.12 +/- 0.2 ka recurrence time for Mw similar to 7.0 normal-faulting earthquakes. We propose that extension in the Pichilemu region is associated with stress changes during megathrust earthquakes and accommodated by sporadic slip during upper-plate earthquakes, which has implications for assessing the seismic potential of cryptic faults along convergent margins and elsewhere.}, language = {en} } @article{AguileraDenaLangerAntoniadisetal.2022, author = {Aguilera-Dena, David R. and Langer, Norbert and Antoniadis, John and Pauli, Daniel and Dessart, Luc and Vigna-G{\´o}mez, Alejandro and Gr{\"a}fener, G{\"o}tz and Yoon, Sung-Chul}, title = {Stripped-envelope stars in different metallicity environments: I. Evolutionary phases, classification, and populations}, series = {Astronomy and astrophysics}, volume = {661}, journal = {Astronomy and astrophysics}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/202142895}, pages = {20}, year = {2022}, abstract = {Massive stars that become stripped of their hydrogen envelope through binary interaction or winds can be observed either as Wolf-Rayet stars, if they have optically thick winds, or as transparent-wind stripped-envelope stars. We approximate their evolution through evolutionary models of single helium stars, and compute detailed model grids in the initial mass range 1.5-70 M. for metallicities between 0.01 and 0.04, from core helium ignition until core collapse. Throughout their lifetimes some stellar models expose the ash of helium burning. We propose that models that have nitrogen-rich envelopes are candidate WN stars, while models with a carbon-rich surface are candidate WC stars during core helium burning, and WO stars afterwards. We measure the metallicity dependence of the total lifetimes of our models and the duration of their evolutionary phases. We propose an analytic estimate of the wind's optical depth to distinguish models of Wolf-Rayet stars from transparent-wind stripped-envelope stars, and find that the luminosity ranges at which WN-, WC-, and WO-type stars can exist is a strong function of metallicity. We find that all carbon-rich models produced in our grids have optically thick winds and match the luminosity distribution of observed populations. We construct population models and predict the numbers of transparent-wind stripped-envelope stars and Wolf-Rayet stars, and derive their number ratios at different metallicities. We find that as metallicity increases, the number of transparent-wind stripped-envelope stars decreases and the number of Wolf-Rayet stars increases. At high metallicities WC- and WO-type stars become more common. We apply our population models to nearby galaxies, and find that populations are more sensitive to the transition luminosity between Wolf-Rayet stars and transparent-wind helium stars than to the metallicity-dependent mass loss rates.}, language = {en} } @misc{CescaStichGrigolietal.2022, author = {Cesca, Simone and Stich, Daniel and Grigoli, Francesco and Vuan, Alessandro and L{\´o}pez-Comino, Jos{\´e} {\´A}ngel and Niemz, Peter and Blanch, Estefan{\´i}a and Dahm, Torsten and Ellsworth, William L.}, title = {Reply to: Multiple induced seismicity mechanisms at Castor underground gas storage illustrate the need for thorough monitoring}, series = {Nature communications}, volume = {13}, journal = {Nature communications}, number = {1}, publisher = {Nature Research}, address = {Berlin}, issn = {2041-1723}, doi = {10.1038/s41467-022-30904-5}, pages = {4}, year = {2022}, language = {en} } @article{HeistermannBogenaFranckeetal.2022, author = {Heistermann, Maik and Bogena, Heye and Francke, Till and G{\"u}ntner, Andreas and Jakobi, Jannis and Rasche, Daniel and Schr{\"o}n, Martin and D{\"o}pper, Veronika and Fersch, Benjamin and Groh, Jannis and Patil, Amol and P{\"u}tz, Thomas and Reich, Marvin and Zacharias, Steffen and Zengerle, Carmen and Oswald, Sascha}, title = {Soil moisture observation in a forested headwater catchment: Combining a dense cosmic-ray neutron sensor network with roving and hydrogravimetry at the TERENO site W{\"u}stebach}, series = {Earth system science data}, volume = {14}, journal = {Earth system science data}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1866-3508}, doi = {10.5194/essd-14-2501-2022}, pages = {2501 -- 2519}, year = {2022}, abstract = {Cosmic-ray neutron sensing (CRNS) has become an effective method to measure soil moisture at a horizontal scale of hundreds of metres and a depth of decimetres. Recent studies proposed operating CRNS in a network with overlapping footprints in order to cover root-zone water dynamics at the small catchment scale and, at the same time, to represent spatial heterogeneity. In a joint field campaign from September to November 2020 (JFC-2020), five German research institutions deployed 15 CRNS sensors in the 0.4 km(2) Wustebach catchment (Eifel mountains, Germany). The catchment is dominantly forested (but includes a substantial fraction of open vegetation) and features a topographically distinct catchment boundary. In addition to the dense CRNS coverage, the campaign featured a unique combination of additional instruments and techniques: hydro-gravimetry (to detect water storage dynamics also below the root zone); ground-based and, for the first time, airborne CRNS roving; an extensive wireless soil sensor network, supplemented by manual measurements; and six weighable lysimeters. Together with comprehensive data from the long-term local research infrastructure, the published data set (available at https://doi.org/10.23728/b2share.756ca0485800474e9dc7f5949c63b872; Heistermann et al., 2022) will be a valuable asset in various research contexts: to advance the retrieval of landscape water storage from CRNS, wireless soil sensor networks, or hydrogravimetry; to identify scale-specific combinations of sensors and methods to represent soil moisture variability; to improve the understanding and simulation of land-atmosphere exchange as well as hydrological and hydrogeological processes at the hillslope and the catchment scale; and to support the retrieval of soil water content from airborne and spaceborne remote sensing platforms.}, language = {en} } @article{FuchsPalmtagJuhlsetal.2022, author = {Fuchs, Matthias and Palmtag, Juri and Juhls, Bennet and Overduin, Pier Paul and Grosse, Guido and Abdelwahab, Ahmed and Bedington, Michael and Sanders, Tina and Ogneva, Olga and Fedorova, Irina and Zimov, Nikita S. and Mann, Paul J. and Strauss, Jens}, title = {High-resolution bathymetry models for the Lena Delta and Kolyma Gulf coastal zones}, series = {Earth system science data}, volume = {14}, journal = {Earth system science data}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1866-3508}, doi = {10.5194/essd-14-2279-2022}, pages = {2279 -- 2301}, year = {2022}, abstract = {Arctic river deltas and deltaic near-shore zones represent important land-ocean transition zones influencing sediment dynamics and nutrient fluxes from permafrost-affected terrestrial ecosystems into the coastal Arctic Ocean. To accurately model fluvial carbon and freshwater export from rapidly changing river catchments as well as assess impacts of future change on the Arctic shelf and coastal ecosystems, we need to understand the sea floor characteristics and topographic variety of the coastal zones. To date, digital bathymetrical data from the poorly accessible, shallow, and large areas of the eastern Siberian Arctic shelves are sparse. We have digitized bathymetrical information for nearly 75 000 locations from large-scale (1 V 25000-1 V 500000) current and historical nautical maps of the Lena Delta and the Kolyma Gulf region in northeastern Siberia. We present the first detailed and seamless digital models of coastal zone bathymetry for both delta and gulf regions in 50 and 200m spatial resolution. We validated the resulting bathymetry layers using a combination of our own water depth measurements and a collection of available depth measurements, which showed a strong correlation (r>0.9). Our bathymetrical models will serve as an input for a high-resolution coupled hydrodynamic-ecosystem model to better quantify fluvial and coastal carbon fluxes to the Arctic Ocean, but they may be useful for a range of other studies related to Arctic delta and near-shore dynamics such as modeling of submarine permafrost, near-shore sea ice, or shelf sediment transport. The new digital high-resolution bathymetry products are available on the PANGAEA data set repository for the Lena Delta (https://doi.org/10.1594/PANGAEA.934045; Fuchs et al., 2021a) and Kolyma Gulf region (https://doi.org/10.1594/PANGAEA.934049; Fuchs et al., 2021b), respectively. Likewise, the depth validation data are available on PANGAEA as well (https://doi.org/10.1594/PANGAEA.933187; Fuchs et al., 2021c).}, language = {en} } @article{JonesGrosseFarquharsonetal.2022, author = {Jones, Benjamin M. and Grosse, Guido and Farquharson, Louise M. and Roy-L{\´e}veill{\´e}e, Pascale and Veremeeva, Alexandra and Kanevskiy, Mikhail Z. and Gaglioti, Benjamin and Breen, Amy L. and Parsekian, Andrew D. and Ulrich, Mathias and Hinkel, Kenneth M.}, title = {Lake and drained lake basin systems in lowland permafrost regions}, series = {Nature reviews earth and environment}, volume = {3}, journal = {Nature reviews earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-138X}, doi = {10.1038/s43017-021-00238-9}, pages = {85 -- 98}, year = {2022}, abstract = {The formation, growth and drainage of lakes in Arctic and boreal lowland permafrost regions influence landscape and ecosystem processes. These lake and drained lake basin (L-DLB) systems occupy >20\% of the circumpolar Northern Hemisphere permafrost region and similar to 50\% of the area below 300 m above sea level. Climate change is causing drastic impacts to L-DLB systems, with implications for permafrost dynamics, ecosystem functioning, biogeochemical processes and human livelihoods in lowland permafrost regions. In this Review, we discuss how an increase in the number of lakes as a result of permafrost thaw and an intensifying hydrologic regime are not currently offsetting the land area gained through lake drainage, enhancing the dominance of drained lake basins (DLBs).The contemporary transition from lakes to DLBs decreases hydrologic storage, leads to permafrost aggradation, increases carbon sequestration and diversifies the shifting habitat mosaic in Arctic and boreal regions. However, further warming could inhibit permafrost aggradation in DLBs, disrupting the trajectory of important microtopographic controls on carbon fluxes and ecosystem processes in permafrost-region L-DLB systems. Further research is needed to understand the future dynamics of L-DLB systems to improve Earth system models, permafrost carbon feedback assessments, permafrost hydrology linkages, infrastructure development in permafrost regions and the well-being of northern socio-ecological systems.}, language = {en} } @article{DerežaninBlažytėDobryninetal.2022, author = {Derežanin, Lorena and Blažytė, Asta and Dobrynin, Pavel and Duch{\^e}ne, David A. and Grau, Jos{\´e} Horacio and Jeon, Sungwon and Kliver, Sergei and Koepfli, Klaus-Peter and Meneghini, Dorina and Preick, Michaela and Tomarovsky, Andrey and Totikov, Azamat and Fickel, J{\"o}rns and F{\"o}rster, Daniel W.}, title = {Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae}, series = {Molecular ecology}, volume = {31}, journal = {Molecular ecology}, number = {10}, publisher = {Wiley}, address = {Hoboken}, issn = {0962-1083}, doi = {10.1111/mec.16443}, pages = {2898 -- 2919}, year = {2022}, abstract = {Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance.}, language = {en} } @article{AbdelilahSeyfriedIruelaArispePenningeretal.2022, author = {Abdelilah-Seyfried, Salim and Iruela-Arispe, M. Luisa and Penninger, Josef M. and Tournier-Lasserve, Elisabeth and Vikkula, Miikka and Cleaver, Ondine}, title = {Recalibrating vascular malformations and mechanotransduction by pharmacological intervention}, series = {Journal of clinical investigation}, volume = {132}, journal = {Journal of clinical investigation}, number = {8}, publisher = {American Society for Clinical Investigation}, address = {Ann Arbor}, issn = {0021-9738}, doi = {10.1172/JCI160227}, pages = {4}, year = {2022}, language = {en} } @article{ZhangWangKuangetal.2022, author = {Zhang, Zhihao and Wang, Ting and Kuang, Jin and Herold, Fabian and Ludyga, Sebastian and Li, Jingming and Hall, Daniel L. and Taylor, Alyx and Healy, Sean and Yeung, Albert S. and Kramer, Arthur F. and Zou, Liye}, title = {The roles of exercise tolerance and resilience in the effect of physical activity on emotional states among college students}, series = {International Journal of Clinical and Health Psychology}, volume = {22}, journal = {International Journal of Clinical and Health Psychology}, number = {3}, publisher = {Elsevier}, address = {New York}, issn = {1697-2600}, doi = {10.1016/j.ijchp.2022.100312}, pages = {8}, year = {2022}, abstract = {Background/objective: Negative emotional states, such as depression, anxiety, and stress challenge health care due to their long-term consequences for mental disorders. Accumulating evidence indicates that regular physical activity (PA) can positively influence negative emotional states. Among possible candidates, resilience and exercise tolerance in particular have the potential to partly explain the positive effects of PA on negative emotional states. Thus, the aim of this study was to investigate the association between PA and negative emotional states, and further determine the mediating effects of exercise tolerance and resilience in such a relationship. Method: In total, 1117 Chinese college students (50.4\% female, Mage=18.90, SD=1.25) completed a psychosocial battery, including the 21-item Depression Anxiety Stress Scale (DASS-21), the Connor-Davidson Resilience Scale (CD-RISC), the Preference for and Tolerance of the Intensity of Exercise Questionnaire (PRETIE-Q), and the International Physical Activity Questionnaire short form (IPAQ-SF). Regression analysis was used to identify the serial multiple mediation, controlling for gender, age and BMI. Results: PA, exercise intensity-tolerance, and resilience were significantly negatively correlated with negative emotional states (Ps<.05). Further, exercise tolerance and resilience partially mediated the relationship between PA and negative emotional states. Conclusions: Resilience and exercise intensity-tolerance can be achieved through regularly engaging in PA, and these newly observed variables play critical roles in prevention of mental illnesses, especially college students who face various challenges. Recommended amount of PA should be incorporated into curriculum or sport clubs within a campus environment.}, language = {en} } @article{RingEisenmannKandiletal.2022, author = {Ring, Raphaela M. and Eisenmann, Clemens and Kandil, Farid and Steckhan, Nico and Demmrich, Sarah and Klatte, Caroline and Kessler, Christian S. and Jeitler, Michael and Boschmann, Michael and Michalsen, Andreas and Blakeslee, Sarah B. and St{\"o}ckigt, Barbara and Stritter, Wiebke and Koppold-Liebscher, Daniela A.}, title = {Mental and behavioural responses to Bah{\´a}'{\´i} fasting: Looking behind the scenes of a religiously motivated intermittent fast using a mixed methods approach}, series = {Nutrients}, volume = {14}, journal = {Nutrients}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2072-6643}, doi = {10.3390/nu14051038}, pages = {23}, year = {2022}, abstract = {Background/Objective: Historically, fasting has been practiced not only for medical but also for religious reasons. Baha'is follow an annual religious intermittent dry fast of 19 days. We inquired into motivation behind and subjective health impacts of Baha'i fasting. Methods: A convergent parallel mixed methods design was embedded in a clinical single arm observational study. Semi-structured individual interviews were conducted before (n = 7), during (n = 8), and after fasting (n = 8). Three months after the fasting period, two focus group interviews were conducted (n = 5/n = 3). A total of 146 Baha'i volunteers answered an online survey at five time points before, during, and after fasting. Results: Fasting was found to play a central role for the religiosity of interviewees, implying changes in daily structures, spending time alone, engaging in religious practices, and experiencing social belonging. Results show an increase in mindfulness and well-being, which were accompanied by behavioural changes and experiences of self-efficacy and inner freedom. Survey scores point to an increase in mindfulness and well-being during fasting, while stress, anxiety, and fatigue decreased. Mindfulness remained elevated even three months after the fast. Conclusion: Baha'i fasting seems to enhance participants' mindfulness and well-being, lowering stress levels and reducing fatigue. Some of these effects lasted more than three months after fasting.}, language = {en} } @article{CaoTianHerzschuhetal.2022, author = {Cao, Xianyong and Tian, Fang and Herzschuh, Ulrike and Ni, Jian and Xu, Qinghai and Li, Wenjia and Zhang, Yanrong and Luo, Mingyu and Chen, Fahu}, title = {Human activities have reduced plant diversity in eastern China over the last two millennia}, series = {Global change biology}, volume = {28}, journal = {Global change biology}, number = {16}, publisher = {Wiley}, address = {Hoboken}, issn = {1354-1013}, doi = {10.1111/gcb.16274}, pages = {4962 -- 4976}, year = {2022}, abstract = {Understanding the history and regional singularities of human impact on vegetation is key to developing strategies for sustainable ecosystem management. In this study, fossil and modern pollen datasets from China are employed to investigate temporal changes in pollen composition, analogue quality, and pollen diversity during the Holocene. Anthropogenic disturbance and vegetation's responses are also assessed. Results reveal that pollen assemblages from non-forest communities fail to provide evidence of human impact for the western part of China (annual precipitation less than 400 mm and/or elevation more than 3000 m.a.s.l.), as inferred from the stable quality of modern analogues, principal components, and diversity of species and communities throughout the Holocene. For the eastern part of China, the proportion of fossil pollen spectra with good modern analogues increases from ca. 50\% to ca. 80\% during the last 2 millennia, indicating an enhanced intensity of anthropogenic disturbance on vegetation. This disturbance has caused the pollen spectra to become taxonomically less diverse over space (reduced abundances of arboreal taxa and increased abundances of herbaceous taxa), highlighting a reduced south-north differentiation and divergence from past vegetation between regions in the eastern part of China. We recommend that care is taken in eastern China when basing the development of ecosystem management strategies on vegetation changes in the region during the last 2000 years, since humans have significantly disturbed the vegetation during this period.}, language = {en} } @article{SarrDonnadieuBoltonetal.2022, author = {Sarr, Anta-Clarisse and Donnadieu, Yannick and Bolton, Clara T. and Ladant, Jean-Baptiste and Licht, Alexis and Fluteau, Fr{\´e}d{\´e}ric and Laugi{\´e}, Marie and Tardif-Becquet, Delphine and Dupont-Nivet, Guillaume}, title = {Neogene South Asian monsoon rainfall and wind histories diverged due to topographic effects}, series = {Nature geoscience}, volume = {15}, journal = {Nature geoscience}, number = {4}, publisher = {Nature Research}, address = {Berlin}, issn = {1752-0894}, doi = {10.1038/s41561-022-00919-0}, pages = {314 -- 319}, year = {2022}, abstract = {The drivers of the evolution of the South Asian Monsoon remain widely debated. An intensification of monsoonal rainfall recorded in terrestrial and marine sediment archives from the earliest Miocene (23-20 million years ago (Ma)) is generally attributed to Himalayan uplift. However, Indian Ocean palaeorecords place the onset of a strong monsoon around 13 Ma, linked to strengthening of the southwesterly winds of the Somali Jet that also force Arabian Sea upwelling. Here we reconcile these divergent records using Earth system model simulations to evaluate the interactions between palaeogeography and ocean-atmosphere dynamics. We show that factors forcing the South Asian Monsoon circulation versus rainfall are decoupled and diachronous. Himalayan and Tibetan Plateau topography predominantly controlled early Miocene rainfall patterns, with limited impact on ocean-atmosphere circulation. The uplift of the East African and Middle Eastern topography played a pivotal role in the establishment of the modern Somali Jet structure above the western Indian Ocean, while strong upwelling initiated as a direct consequence of the emergence of the Arabian Peninsula and the onset of modern-like atmospheric circulation. Our results emphasize that although elevated rainfall seasonality was probably a persistent feature since the India-Asia collision in the Paleogene, modern-like monsoonal atmospheric circulation only emerged in the late Neogene.}, language = {en} } @article{BarcenaAslamPozdniakovaetal.2022, author = {Barcena, Maria Luisa and Aslam, Muhammad and Pozdniakova, Sofya and Norman, Kristina and Ladilov, Yury}, title = {Cardiovascular inflammaging: mechanisms and translational aspects}, series = {Cells}, volume = {11}, journal = {Cells}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells11061010}, pages = {15}, year = {2022}, abstract = {Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.}, language = {en} } @book{KubanRottaNolteetal.2023, author = {Kuban, Robert and Rotta, Randolf and Nolte, J{\"o}rg and Chromik, Jonas and Beilharz, Jossekin Jakob and Pirl, Lukas and Friedrich, Tobias and Lenzner, Pascal and Weyand, Christopher and Juiz, Carlos and Bermejo, Belen and Sauer, Joao and Coelh, Leandro dos Santos and Najafi, Pejman and P{\"u}nter, Wenzel and Cheng, Feng and Meinel, Christoph and Sidorova, Julia and Lundberg, Lars and Vogel, Thomas and Tran, Chinh and Moser, Irene and Grunske, Lars and Elsaid, Mohamed Esameldin Mohamed and Abbas, Hazem M. and Rula, Anisa and Sejdiu, Gezim and Maurino, Andrea and Schmidt, Christopher and H{\"u}gle, Johannes and Uflacker, Matthias and Nozza, Debora and Messina, Enza and Hoorn, Andr{\´e} van and Frank, Markus and Schulz, Henning and Alhosseini Almodarresi Yasin, Seyed Ali and Nowicki, Marek and Muite, Benson K. and Boysan, Mehmet Can and Bianchi, Federico and Cremaschi, Marco and Moussa, Rim and Abdel-Karim, Benjamin M. and Pfeuffer, Nicolas and Hinz, Oliver and Plauth, Max and Polze, Andreas and Huo, Da and Melo, Gerard de and Mendes Soares, F{\´a}bio and Oliveira, Roberto C{\´e}lio Lim{\~a}o de and Benson, Lawrence and Paul, Fabian and Werling, Christian and Windheuser, Fabian and Stojanovic, Dragan and Djordjevic, Igor and Stojanovic, Natalija and Stojnev Ilic, Aleksandra and Weidmann, Vera and Lowitzki, Leon and Wagner, Markus and Ifa, Abdessatar Ben and Arlos, Patrik and Megia, Ana and Vendrell, Joan and Pfitzner, Bjarne and Redondo, Alberto and R{\´i}os Insua, David and Albert, Justin Amadeus and Zhou, Lin and Arnrich, Bert and Szab{\´o}, Ildik{\´o} and Fodor, Szabina and Ternai, Katalin and Bhowmik, Rajarshi and Campero Durand, Gabriel and Shevchenko, Pavlo and Malysheva, Milena and Prymak, Ivan and Saake, Gunter}, title = {HPI Future SOC Lab - Proceedings 2019}, number = {158}, editor = {Meinel, Christoph and Polze, Andreas and Beins, Karsten and Strotmann, Rolf and Seibold, Ulrich and R{\"o}dszus, Kurt and M{\"u}ller, J{\"u}rgen}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-564-4}, issn = {1613-5652}, doi = {10.25932/publishup-59791}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-597915}, publisher = {Universit{\"a}t Potsdam}, pages = {xi, 301}, year = {2023}, abstract = {The "HPI Future SOC Lab" is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2019. Selected projects have presented their results on April 9th and November 12th 2019 at the Future SOC Lab Day events.}, language = {en} } @phdthesis{Richly2024, author = {Richly, Keven}, title = {Memory-efficient data management for spatio-temporal applications}, doi = {10.25932/publishup-63547}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-635473}, school = {Universit{\"a}t Potsdam}, pages = {xii, 181}, year = {2024}, abstract = {The wide distribution of location-acquisition technologies means that large volumes of spatio-temporal data are continuously being accumulated. Positioning systems such as GPS enable the tracking of various moving objects' trajectories, which are usually represented by a chronologically ordered sequence of observed locations. The analysis of movement patterns based on detailed positional information creates opportunities for applications that can improve business decisions and processes in a broad spectrum of industries (e.g., transportation, traffic control, or medicine). Due to the large data volumes generated in these applications, the cost-efficient storage of spatio-temporal data is desirable, especially when in-memory database systems are used to achieve interactive performance requirements. To efficiently utilize the available DRAM capacities, modern database systems support various tuning possibilities to reduce the memory footprint (e.g., data compression) or increase performance (e.g., additional indexes structures). By considering horizontal data partitioning, we can independently apply different tuning options on a fine-grained level. However, the selection of cost and performance-balancing configurations is challenging, due to the vast number of possible setups consisting of mutually dependent individual decisions. In this thesis, we introduce multiple approaches to improve spatio-temporal data management by automatically optimizing diverse tuning options for the application-specific access patterns and data characteristics. Our contributions are as follows: (1) We introduce a novel approach to determine fine-grained table configurations for spatio-temporal workloads. Our linear programming (LP) approach jointly optimizes the (i) data compression, (ii) ordering, (iii) indexing, and (iv) tiering. We propose different models which address cost dependencies at different levels of accuracy to compute optimized tuning configurations for a given workload, memory budgets, and data characteristics. To yield maintainable and robust configurations, we further extend our LP-based approach to incorporate reconfiguration costs as well as optimizations for multiple potential workload scenarios. (2) To optimize the storage layout of timestamps in columnar databases, we present a heuristic approach for the workload-driven combined selection of a data layout and compression scheme. By considering attribute decomposition strategies, we are able to apply application-specific optimizations that reduce the memory footprint and improve performance. (3) We introduce an approach that leverages past trajectory data to improve the dispatch processes of transportation network companies. Based on location probabilities, we developed risk-averse dispatch strategies that reduce critical delays. (4) Finally, we used the use case of a transportation network company to evaluate our database optimizations on a real-world dataset. We demonstrate that workload-driven fine-grained optimizations allow us to reduce the memory footprint (up to 71\% by equal performance) or increase the performance (up to 90\% by equal memory size) compared to established rule-based heuristics. Individually, our contributions provide novel approaches to the current challenges in spatio-temporal data mining and database research. Combining them allows in-memory databases to store and process spatio-temporal data more cost-efficiently.}, language = {en} } @phdthesis{Frank2024, author = {Frank, Mario}, title = {On synthesising Linux kernel module components from Coq formalisations}, doi = {10.25932/publishup-64255}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-642558}, school = {Universit{\"a}t Potsdam}, pages = {IX, 78}, year = {2024}, abstract = {This thesis presents an attempt to use source code synthesised from Coq formalisations of device drivers for existing (micro)kernel operating systems, with a particular focus on the Linux Kernel. In the first part, the technical background and related work are described. The focus is here on the possible approaches to synthesising certified software with Coq, namely the extraction to functional languages using the Coq extraction plugin and the extraction to Clight code using the CertiCoq plugin. It is noted that the implementation of CertiCoq is verified, whereas this is not the case for the Coq extraction plugin. Consequently, there is a correctness guarantee for the generated Clight code which does not hold for the code being generated by the Coq extraction plugin. Furthermore, the differences between user space and kernel space software are discussed in relation to Linux device drivers. It is elaborated that it is not possible to generate working Linux kernel module components using the Coq extraction plugin without significant modifications. In contrast, it is possible to produce working user space drivers both with the Coq extraction plugin and CertiCoq. The subsequent parts describe the main contributions of the thesis. In the second part, it is demonstrated how to extend the Coq extraction plugin to synthesise foreign function calls between the functional language OCaml and the imperative language C. This approach has the potential to improve the type-safety of user space drivers. Furthermore, it is shown that the code being synthesised by CertiCoq cannot be used in kernel space without modifications to the necessary runtime. Consequently, the necessary modifications to the runtimes of CertiCoq and VeriFFI are introduced, resulting in the runtimes becoming compatible components of a Linux kernel module. Furthermore, justifications for the transformations are provided and possible further extensions to both plugins and solutions to failing garbage collection calls in kernel space are discussed. The third part presents a proof of concept device driver for the Linux Kernel. To achieve this, the event handler of the original PC Speaker driver is partially formalised in Coq. Furthermore, some relevant formal properties of the formalised functionality are discussed. Subsequently, a kernel module is defined, utilising the modified variants of CertiCoq and VeriFFI to compile a working device driver. It is furthermore shown that it is possible to compile the synthesised code with CompCert, thereby extending the guarantee of correctness to the assembly layer. This is followed by a performance evaluation that compares a naive formalisation of the PC speaker functionality with the original PC Speaker driver pointing out the weaknesses in the formalisation and possible improvements. The part closes with a summary of the results, their implications and open questions being raised. The last part lists all used sources, separated into scientific literature, documentations or reference manuals and artifacts, i.e. source code.}, language = {en} } @article{GiannettiUmanskySened2022, author = {Giannetti, Daniela and Umansky, Karen and Sened, Itai}, title = {The entry of the M5S and the reshaping of party politics in Italy (2008-2018)}, series = {Government \& opposition}, volume = {59}, journal = {Government \& opposition}, number = {2}, publisher = {Cambridge University Press}, address = {Cambridge}, issn = {0017-257X}, doi = {10.1017/gov.2022.38}, pages = {464 -- 481}, year = {2022}, abstract = {This article examines how challenger parties enter the political arena and the effect of this entry by looking at the Italian 5 Star Movement (Movimento 5 Stelle - M5S). We explain the M5S's entry strategy in 2013 using the spatial approach to party competition and employing expert survey data collected for each national election between 2008 and 2018. These data allow us to analyse the changing spatial configuration of Italian politics due to the increasing salience of pro/anti-EU and pro/anti-immigration dimensions. We then apply the theoretical notion of the uncovered set (UCS) to trace how the M5S's entry reshaped the overall space of party competition, causing a realignment of existing parties. This work contributes to the ongoing debate on the electoral success of challenger parties and the emerging cleavages and polarization of party systems in Western European countries.}, language = {en} } @phdthesis{Montulet2024, author = {Montulet, Orianne}, title = {Functional characterization of putative interactors of the Cellulose Synthase Complex}, school = {Universit{\"a}t Potsdam}, pages = {160}, year = {2024}, abstract = {The plant cell wall plays several crucial roles during plant development with its integrity acting as key signalling component for growth regulation during biotic and abiotic stresses. Cellulose microfibrils, the principal load-bearing components is the major component of the primary cell wall, whose synthesis is mediated by microtubule-associated CELLULOSE SYNTHASE (CESA) COMPLEXES (CSC). Previous studies have shown that CSC interacting proteins COMPANION OF CELLULOSE SYNTHASE (CC) facilitate sustained cellulose synthesis during salt stress by promoting repolymerization of cortical microtubules. However, our understanding of cellulose synthesis during salt stress remains incomplete. In this study, a pull-down of CC1 protein led to the identification of a novel interactor, termed LEA-like. Phylogenetic analysis revealed that LEA-like belongs to the LATE EMBRYOGENESIS ABUNDANT (LEA) protein family, specifically to the LEA_2 subgroup, showing a close relationship with the CC proteins. Roots of the double mutants lea-like and its closest homolog emb3135 exhibited hypersensitivity when grown on cellulose synthesis inhibitors. Further analysis of higher-order mutants of lea-like, emb3135, and cesa6 demonstrated a genetic interaction between them indicating a significant role in cellulose synthesis. Live-cell imaging revealed that both LEA-like and EMB3135 migrated with the CSC at the plasma membrane along microtubule tracks in control and oryzalin-treated conditions which destabilize microtubules, suggesting a tight interaction. Investigation of fluorescently labeled lines of different domains of the LEA-like protein revealed that the N-terminal cytosolic domain of LEA-like colocalizes with microtubules, suggesting a physical association between the two. Considering the established role of LEA proteins in abiotic stress tolerance, we performed phenotypic analysis of the mutant under various stresses. Growth of double mutants of lea-like and emb3135 on NaCl containing media resulted in swelling of root cell indicating a putative role in salt stress tolerance. Supportive of this the quadruple mutant, lacking LEA-like, EMB3135, CC1, and CC2 proteins, exhibited a severe root growth defect on NaCl media compared to control conditions. Live-cell imaging revealed that under salt stress, the LEA-like protein forms aggregates in the plasma membrane. In conclusion, this study has unveiled two novel interactors of the CSC that act with the CC proteins that regulate plant growth in response to salt stress providing new insights into the intricate regulation of cellulose synthesis, particularly under such conditions.}, language = {en} } @phdthesis{Apodiakou2024, author = {Apodiakou, Anastasia}, title = {Analysis of the regulation of SDI genes, unravelling the role of the SLIM1 transcription factor, and the SNRK3.15 kinase in Arabidopsis under sulfur deprivation}, school = {Universit{\"a}t Potsdam}, pages = {141}, year = {2024}, language = {en} } @phdthesis{Seerangan2023, author = {Seerangan, Kumar}, title = {Actin-based regulation of cell and tissue scale morphogenesis in developing leaves}, school = {Universit{\"a}t Potsdam}, pages = {120}, year = {2023}, language = {en} } @article{MarinBeloquiZhangGuoetal.2022, author = {Marin-Beloqui, Jose and Zhang, Guanran and Guo, Junjun and Shaikh, Jordan and Wohrer, Thibaut and Hosseini, Seyed Mehrdad and Sun, Bowen and Shipp, James and Auty, Alexander J. and Chekulaev, Dimitri and Ye, Jun and Chin, Yi-Chun and Sullivan, Michael B. and Mozer, Attila J. and Kim, Ji-Seon and Shoaee, Safa and Clarke, Tracey M.}, title = {Insight into the origin of trapping in polymer/fullerene blends with a systematic alteration of the fullerene to higher adducts}, series = {Journal of physical chemistry C}, volume = {126}, journal = {Journal of physical chemistry C}, number = {5}, publisher = {American Chemical Society}, address = {Washington}, issn = {1932-7447}, doi = {10.1021/acs.jpcc.1c10378}, pages = {2708 -- 2719}, year = {2022}, abstract = {The bimolecular recombination characteristics of conjugated polymer poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d]silole)-2,6-diyl-alt-(2,5-bis 3-tetradecylthiophen-2-y1 thiazolo 5,4-d thiazole)-2,5diy1] (PDTSiTTz) blended with the fullerene series PC60BM, ICMA, ICBA, and ICTA have been investigated using microsecond and femtosecond transient absorption spectroscopy, in conjunction with electroluminescence measurements and ambient photoemission spectroscopy. The non-Langevin polymer PDTSiTTz allows an inspection of intrinsic bimolecular recombination rates uninhibited by diffusion, while the low oscillator strengths of fullerenes allow polymer features to dominate, and we compare our results to those of the well-known polymer Si-PCPDTBT. Using mu s-TAS, we have shown that the trap -limited decay dynamics of the PDTSiTTz polaron becomes progressively slower across the fullerene series, while those of Si-PCPDTBT are invariant. Electroluminescence measurements showed an unusual double peak in pristine PDTSiTTz, attributed to a low energy intragap charge transfer state, likely interchain in nature. Furthermore, while the pristine PDTSiTTz showed a broad, low-intensity density of states, the ICBA and ICTA blends presented a virtually identical DOS to Si-PCPDTBT and its blends. This has been attributed to a shift from a delocalized, interchain highest occupied molecular orbital (HOMO) in the pristine material to a dithienosilole-centered HOMO in the blends, likely a result of the bulky fullerenes increasing interchain separation. This HOMO localization had a side effect of progressively shifting the polymer HOMO to shallower energies, which was correlated with the observed decrease in bimolecular recombination rate and increased "trap" depth. However, since the density of tail states remained the same, this suggests that the traditional viewpoint of "trapping" being dominated by tail states may not encompass the full picture and that the breadth of the DOS may also have a strong influence on bimolecular recombination.}, language = {en} } @article{FlovenzWangHersiretal.2022, author = {Fl{\´o}venz, {\´O}lafur G. and Wang, Rongjiang and Hersir, Gylfi P{\´a}ll and Dahm, Torsten and Hainzl, Sebastian and Vassileva, Magdalena and Drouin, Vincent and Heimann, Sebastian and Isken, Marius Paul and Gudnason, Egill {\´A}. and {\´A}g{\´u}stsson, Kristj{\´a}n and {\´A}g{\´u}stsd{\´o}ttir, Thorbj{\"o}rg and Hor{\´a}lek, Josef and Motagh, Mahdi and Walter, Thomas R. and Rivalta, Eleonora and Jousset, Philippe and Krawczyk, Charlotte M. and Milkereit, Claus}, title = {Cyclical geothermal unrest as a precursor to Iceland's 2021 Fagradalsfjall eruption}, series = {Nature geoscience}, volume = {15}, journal = {Nature geoscience}, number = {5}, publisher = {Nature Research}, address = {Berlin}, issn = {1752-0894}, doi = {10.1038/s41561-022-00930-5}, pages = {397 -- 404}, year = {2022}, abstract = {Understanding and constraining the source of geodetic deformation in volcanic areas is an important component of hazard assessment. Here, we analyse deformation and seismicity for one year before the March 2021 Fagradalsfjall eruption in Iceland. We generate a high-resolution catalogue of 39,500 earthquakes using optical cable recordings and develop a poroelastic model to describe three pre-eruptional uplift and subsidence cycles at the Svartsengi geothermal field, 8 km west of the eruption site. We find the observed deformation is best explained by cyclic intrusions into a permeable aquifer by a fluid injected at 4 km depth below the geothermal field, with a total volume of 0.11 ± 0.05 km3 and a density of 850 ± 350 kg m-3. We therefore suggest that ingression of magmatic CO2 can explain the geodetic, gravity and seismic data, although some contribution of magma cannot be excluded.}, language = {en} } @article{KayaDupontNivetFrielingetal.2022, author = {Kaya, Mustafa Y{\"u}cel and Dupont-Nivet, Guillaume and Frieling, Joost and Fioroni, Chiara and Rohrmann, Alexander and Alt{\i}ner, Sevin{\c{c}} {\"O}zkan and Vardar, Ezgi and Tanyas, Hakan and Mamtimin, Mehmut and Zhaojie, Guo}, title = {The Eurasian epicontinental sea was an important carbon sink during the Palaeocene-Eocene thermal maximum}, series = {Communications earth and environment}, volume = {3}, journal = {Communications earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-022-00451-4}, pages = {10}, year = {2022}, abstract = {The Palaeocene-Eocene Thermal Maximum (ca. 56 million years ago) offers a primary analogue for future global warming and carbon cycle recovery. Yet, where and how massive carbon emissions were mitigated during this climate warming event remains largely unknown. Here we show that organic carbon burial in the vast epicontinental seaways that extended over Eurasia provided a major carbon sink during the Palaeocene-Eocene Thermal Maximum. We coupled new and existing stratigraphic analyses to a detailed paleogeographic framework and using spatiotemporal interpolation calculated ca. 720-1300 Gt organic carbon excess burial, focused in the eastern parts of the Eurasian epicontinental seaways. A much larger amount (2160-3900 Gt C, and when accounting for the increase in inundated shelf area 7400-10300 Gt C) could have been sequestered in similar environments globally. With the disappearance of most epicontinental seas since the Oligocene-Miocene, an effective negative carbon cycle feedback also disappeared making the modern carbon cycle critically dependent on the slower silicate weathering feedback.}, language = {en} } @phdthesis{Hagemann2024, author = {Hagemann, Justus}, title = {On the molecular evolution of sengis (Macroscelidea)}, doi = {10.25932/publishup-64197}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-641975}, school = {Universit{\"a}t Potsdam}, pages = {xiii, 144}, year = {2024}, abstract = {This thesis focuses on the molecular evolution of Macroscelidea, commonly referred to as sengis. Sengis are a mammalian order belonging to the Afrotherians, one of the four major clades of placental mammals. Sengis currently consist of twenty extant species, all of which are endemic to the African continent. They can be separated in two families, the soft-furred sengis (Macroscelididae) and the giant sengis (Rhynchocyonidae). While giant sengis can be exclusively found in forest habitats, the different soft-furred sengi species dwell in a broad range of habitats, from tropical rain-forests to rocky deserts. Our knowledge on the evolutionary history of sengis is largely incomplete. The high level of superficial morphological resemblance among different sengi species (especially the soft-furred sengis) has for example led to misinterpretations of phylogenetic relationships, based on morphological characters. With the rise of DNA based taxonomic inferences, multiple new genera were defined and new species described. Yet, no full taxon molecular phylogeny exists, hampering the answering of basic taxonomic questions. This lack of knowledge can be to some extent attributed to the limited availability of fresh-tissue samples for DNA extraction. The broad African distribution, partly in political unstable regions and low population densities complicate contemporary sampling approaches. Furthermore, the DNA information available usually covers only short stretches of the mitochondrial genome and thus a single genetic locus with limited informational content. Developments in DNA extraction and library protocols nowadays offer the opportunity to access DNA from museum specimens, collected over the past centuries and stored in natural history museums throughout the world. Thus, the difficulties in fresh-sample acquisition for molecular biological studies can be overcome by the application of museomics, the research field which emerged from those laboratory developments. This thesis uses fresh-tissue samples as well as a vast collection museum specimens to investigate multiple aspects about the macroscelidean evolutionary history. Chapter 4 of this thesis focuses on the phylogenetic relationships of all currently known sengi species. By accessing DNA information from museum specimens in combination of fresh tissue samples and publicly available genetic resources it produces the first full taxon molecular phylogeny of sengis. It confirms the monophyly of the genus Elephantulus and discovers multiple deeply divergent lineages within different species, highlighting the need for species specific approaches. The study furthermore focuses on the evolutionary time frame of sengis by evaluating the impact of commonly varied parameters on tree dating. The results of the study show, that the mitochondrial information used in previous studies to temporal calibrate the Macroscelidean phylogeny led to an overestimation of node ages within sengis. Especially soft-furred sengis are thus much younger than previously assumed. The refined knowledge of nodes ages within sengis offer the opportunity to link e.g. speciation events to environmental changes. Chapter 5 focuses on the genus Petrodromus with its single representative Petrodromus tetradactylus. It again exploits the opportunities of museomics and gathers a comprehensive, multi-locus genetic dataset of P. tetradactylus individuals, distributed across most the known range of this species. It reveals multiple deeply divergent lineages within Petrodromus, whereby some could possibly be associated to previously described sub-species, at least one was formerly unknown. It underscores the necessity for a revision of the genus Petrodromus through the integration of both molecular and morphological evidence. The study, furthermore identifies changing forest distributions through climatic oscillations as main factor shaping the genetic structure of Petrodromus. Chapter 6 uses fresh tissue samples to extent the genomic resources of sengis by thirteen new nuclear genomes, of which two were de-novo assembled. An extensive dataset of more than 8000 protein coding one-to-one orthologs allows to further refine and confirm the temporal time frame of sengi evolution found in Chapter 4. This study moreover investigates the role of gene-flow and incomplete lineage sorting (ILS) in sengi evolution. In addition it identifies clade specific genes of possible outstanding evolutionary importance and links them to potential phenotypic traits affected. A closer investigation of olfactory receptor proteins reveals clade specific differences. A comparison of the demographic past of sengis to other small African mammals does not reveal a sengi specific pattern.}, language = {en} } @article{KloseGuillemoteauVignolietal.2023, author = {Klose, Tim and Guillemoteau, Julien and Vignoli, Giulio and Walter, Judith and Herrmann, Andreas and Tronicke, Jens}, title = {Structurally constrained inversion by means of a Minimum Gradient Support regularizer: examples of FD-EMI data inversion constrained by GPR reflection data}, series = {Geophysical journal international}, volume = {233}, journal = {Geophysical journal international}, number = {3}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggad041}, pages = {1938 -- 1949}, year = {2023}, abstract = {Many geophysical inverse problems are known to be ill-posed and, thus, requiring some kind of regularization in order to provide a unique and stable solution. A possible approach to overcome the inversion ill-posedness consists in constraining the position of the model interfaces. For a grid-based parameterization, such a structurally constrained inversion can be implemented by adopting the usual smooth regularization scheme in which the local weight of the regularization is reduced where an interface is expected. By doing so, sharp contrasts are promoted at interface locations while standard smoothness constraints keep affecting the other regions of the model. In this work, we present a structurally constrained approach and test it on the inversion of frequency-domain electromagnetic induction (FD-EMI) data using a regularization approach based on the Minimum Gradient Support stabilizer, which is capable to promote sharp transitions everywhere in the model, i.e., also in areas where no structural a prioriinformation is available. Using 1D and 2D synthetic data examples, we compare the proposed approach to a structurally constrained smooth inversion as well as to more standard (i.e., not structurally constrained) smooth and sharp inversions. Our results demonstrate that the proposed approach helps in finding a better and more reliable reconstruction of the subsurface electrical conductivity distribution, including its structural characteristics. Furthermore, we demonstrate that it allows to promote sharp parameter variations in areas where no structural information are available. Lastly, we apply our structurally constrained scheme to FD-EMI field data collected at a field site in Eastern Germany to image the thickness of peat deposits along two selected profiles. In this field example, we use collocated constant offset ground-penetrating radar (GPR) data to derive structural a priori information to constrain the inversion of the FD-EMI data. The results of this case study demonstrate the effectiveness and flexibility of the proposed approach.}, language = {en} } @article{CordobaTongBurgosetal.2023, author = {C{\´o}rdoba, Sandra Correa and Tong, Hao and Burgos, Asdrubal and Zhu, Feng and Alseekh, Saleh and Fernie, Alisdair R. and Nikoloski, Zoran}, title = {Identification of gene function based on models capturing natural variability of Arabidopsis thaliana lipid metabolism}, series = {Nature Communications}, volume = {14}, journal = {Nature Communications}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/s41467-023-40644-9}, pages = {12}, year = {2023}, abstract = {The use of automated tools to reconstruct lipid metabolic pathways is not warranted in plants. Here, the authors construct Plant Lipid Module for Arabidopsis rosette using constraint-based modeling, demonstrate its integration in other plant metabolic models, and use it to dissect the genetic architecture of lipid metabolism. Lipids play fundamental roles in regulating agronomically important traits. Advances in plant lipid metabolism have until recently largely been based on reductionist approaches, although modulation of its components can have system-wide effects. However, existing models of plant lipid metabolism provide lumped representations, hindering detailed study of component modulation. Here, we present the Plant Lipid Module (PLM) which provides a mechanistic description of lipid metabolism in the Arabidopsis thaliana rosette. We demonstrate that the PLM can be readily integrated in models of A. thaliana Col-0 metabolism, yielding accurate predictions (83\%) of single lethal knock-outs and 75\% concordance between measured transcript and predicted flux changes under extended darkness. Genome-wide associations with fluxes obtained by integrating the PLM in diel condition- and accession-specific models identify up to 65 candidate genes modulating A. thaliana lipid metabolism. Using mutant lines, we validate up to 40\% of the candidates, paving the way for identification of metabolic gene function based on models capturing natural variability in metabolism.}, language = {en} } @article{CescaSuganRudzinskietal.2022, author = {Cesca, Simone and Sugan, Monica and Rudzinski, Lukasz and Vajedian, Sanaz and Niemz, Peter and Plank, Simon and Petersen, Gesa and Deng, Zhiguo and Rivalta, Eleonora and Vuan, Alessandro and Linares, Milton Percy Plasencia and Heimann, Sebastian and Dahm, Torsten}, title = {Massive earthquake swarm driven by magmatic intrusion at the Bransfield Strait, Antarctica}, series = {Communications earth and environment}, volume = {3}, journal = {Communications earth and environment}, number = {1}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-022-00418-5}, pages = {11}, year = {2022}, abstract = {An earthquake swarm affected the Bransfield Strait, Antarctica, a unique rift basin in transition from intra-arc rifting to ocean spreading. The swarm, counting similar to 85,000 volcano-tectonic earthquakes since August 2020, is located close to the Orca submarine volcano, previously considered inactive. Simultaneously, geodetic data reported up to similar to 11 cm north-westward displacement over King George Island. We use a broad variety of geophysical data and methods to reveal the complex migration of seismicity, accompanying the intrusion of 0.26-0.56 km(3) of magma. Strike-slip earthquakes mark the intrusion at depth, while shallower normal faulting the similar to 20 km long lateral growth of a dike. Seismicity abruptly decreased after a Mw 6.0 earthquake, suggesting the magmatic dike lost pressure with the slipping of a large fault. A seafloor eruption is likely, but not confirmed by sea surface temperature anomalies. The unrest documents episodic magmatic intrusion in the Bransfield Strait, providing unique insights into active continental rifting.}, language = {en} } @article{BouamraZouhalRateletal.2022, author = {Bouamra, Marwa and Zouhal, Hassane and Ratel, S{\´e}bastien and Makhlouf, Issam and Bezrati, Ikram and Chtara, Mokhtar and Behm, David G. and Granacher, Urs and Chaouachi, Anis}, title = {Concurrent training promotes greater gains on body composition and components of physical fitness than single-mode training (endurance or resistance) in youth with obesity}, series = {Frontiers in physiology}, volume = {13}, journal = {Frontiers in physiology}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2022.869063}, pages = {16}, year = {2022}, abstract = {The prevalence of obesity in the pediatric population has become a major public health issue. Indeed, the dramatic increase of this epidemic causes multiple and harmful consequences, Physical activity, particularly physical exercise, remains to be the cornerstone of interventions against childhood obesity. Given the conflicting findings with reference to the relevant literature addressing the effects of exercise on adiposity and physical fitness outcomes in obese children and adolescents, the effect of duration-matched concurrent training (CT) [50\% resistance (RT) and 50\% high-intensity-interval-training (HIIT)] on body composition and physical fitness in obese youth remains to be elucidated. Thus, the purpose of this study was to examine the effects of 9-weeks of CT compared to RT or HIIT alone, on body composition and selected physical fitness components in healthy sedentary obese youth. Out of 73 participants, only 37; [14 males and 23 females; age 13.4 +/- 0.9 years; body-mass-index (BMI): 31.2 +/- 4.8 kg center dot m-2] were eligible and randomized into three groups: HIIT (n = 12): 3-4 setsx12 runs at 80-110\% peak velocity, with 10-s passive recovery between bouts; RT (n = 12): 6 exercises; 3-4 sets x 10 repetition maximum (RM) and CT (n = 13): 50\% serial completion of RT and HIIT. CT promoted significant greater gains compared to HIIT and RT on body composition (p < 0.01, d = large), 6-min-walking test distance (6 MWT-distance) and on 6 MWT-VO2max (p < 0.03, d = large). In addition, CT showed substantially greater improvements than HIIT in the medicine ball throw test (20.2 vs. 13.6\%, p < 0.04, d = large). On the other hand, RT exhibited significantly greater gains in relative hand grip strength (p < 0.03, d = large) and CMJ (p < 0.01, d = large) than HIIT and CT. CT promoted greater benefits for fat, body mass loss and cardiorespiratory fitness than HIIT or RT modalities. This study provides important information for practitioners and therapists on the application of effective exercise regimes with obese youth to induce significant and beneficial body composition changes. The applied CT program and the respective programming parameters in terms of exercise intensity and volume can be used by practitioners as an effective exercise treatment to fight the pandemic overweight and obesity in youth.}, language = {en} } @article{ChengDennisOsuohaetal.2023, author = {Cheng, Feng and Dennis, Alice B. and Osuoha, Josephine Ijeoma and Canitz, Julia and Kirschbaum, Frank and Tiedemann, Ralph}, title = {A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha}, series = {BMC genomics}, volume = {24}, journal = {BMC genomics}, number = {1}, publisher = {BMC}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-023-09196-6}, pages = {13}, year = {2023}, abstract = {Background Teleost fishes comprise more than half of the vertebrate species. Within teleosts, most phylogenies consider the split between Osteoglossomorpha and Euteleosteomorpha/Otomorpha as basal, preceded only by the derivation of the most primitive group of teleosts, the Elopomorpha. While Osteoglossomorpha are generally species poor, the taxon contains the African weakly electric fish (Mormyroidei), which have radiated into numerous species. Within the mormyrids, the genus Campylomormyrus is mostly endemic to the Congo Basin. Campylomormyrus serves as a model to understand mechanisms of adaptive radiation and ecological speciation, especially with regard to its highly diverse species-specific electric organ discharges (EOD). Currently, there are few well-annotated genomes available for electric fish in general and mormyrids in particular. Our study aims at producing a high-quality genome assembly and to use this to examine genome evolution in relation to other teleosts. This will facilitate further understanding of the evolution of the osteoglossomorpha fish in general and of electric fish in particular. Results A high-quality weakly electric fish (C. compressirostris) genome was produced from a single individual with a genome size of 862 Mb, consisting of 1,497 contigs with an N50 of 1,399 kb and a GC-content of 43.69\%. Gene predictions identified 34,492 protein-coding genes, which is a higher number than in the two other available Osteoglossomorpha genomes of Paramormyrops kingsleyae and Scleropages formosus. A Computational Analysis of gene Family Evolution (CAFE5) comparing 33 teleost fish genomes suggests an overall faster gene family turnover rate in Osteoglossomorpha than in Otomorpha and Euteleosteomorpha. Moreover, the ratios of expanded/contracted gene family numbers in Osteoglossomorpha are significantly higher than in the other two taxa, except for species that had undergone an additional genome duplication (Cyprinus carpio and Oncorhynchus mykiss). As potassium channel proteins are hypothesized to play a key role in EOD diversity among species, we put a special focus on them, and manually curated 16 Kv1 genes. We identified a tandem duplication in the KCNA7a gene in the genome of C. compressirostris. Conclusions We present the fourth genome of an electric fish and the third well-annotated genome for Osteoglossomorpha, enabling us to compare gene family evolution among major teleost lineages. Osteoglossomorpha appear to exhibit rapid gene family evolution, with more gene family expansions than contractions. The curated Kv1 gene family showed seven gene clusters, which is more than in other analyzed fish genomes outside Osteoglossomorpha. The KCNA7a, encoding for a potassium channel central for EOD production and modulation, is tandemly duplicated which may related to the diverse EOD observed among Campylomormyrus species.}, language = {en} } @article{RosinLaiMouldetal.2022, author = {Rosin, Paul L. and Lai, Yu-Kun and Mould, David and Yi, Ran and Berger, Itamar and Doyle, Lars and Lee, Seungyong and Li, Chuan and Liu, Yong-Jin and Semmo, Amir and Shamir, Ariel and Son, Minjung and Winnem{\"o}ller, Holger}, title = {NPRportrait 1.0: A three-level benchmark for non-photorealistic rendering of portraits}, series = {Computational visual media}, volume = {8}, journal = {Computational visual media}, number = {3}, publisher = {Springer Nature}, address = {London}, issn = {2096-0433}, doi = {10.1007/s41095-021-0255-3}, pages = {445 -- 465}, year = {2022}, abstract = {Recently, there has been an upsurge of activity in image-based non-photorealistic rendering (NPR), and in particular portrait image stylisation, due to the advent of neural style transfer (NST). However, the state of performance evaluation in this field is poor, especially compared to the norms in the computer vision and machine learning communities. Unfortunately, the task of evaluating image stylisation is thus far not well defined, since it involves subjective, perceptual, and aesthetic aspects. To make progress towards a solution, this paper proposes a new structured, three-level, benchmark dataset for the evaluation of stylised portrait images. Rigorous criteria were used for its construction, and its consistency was validated by user studies. Moreover, a new methodology has been developed for evaluating portrait stylisation algorithms, which makes use of the different benchmark levels as well as annotations provided by user studies regarding the characteristics of the faces. We perform evaluation for a wide variety of image stylisation methods (both portrait-specific and general purpose, and also both traditional NPR approaches and NST) using the new benchmark dataset.}, language = {en} } @article{IrrgangBendixenFarquharsonetal.2022, author = {Irrgang, Anna M. and Bendixen, Mette and Farquharson, Louise M. and Baranskaya, Alisa and Erikson, Li H. and Gibbs, Ann E. and Ogorodov, Stanislav A. and Overduin, Pier Paul and Lantuit, Hugues and Grigoriev, Mikhail N. and Jones, Benjamin M.}, title = {Drivers, dynamics and impacts of changing Arctic coasts}, series = {Nature reviews earth and environment}, volume = {3}, journal = {Nature reviews earth and environment}, number = {1}, publisher = {Nature Research}, address = {London}, issn = {2662-138X}, doi = {10.1038/s43017-021-00232-1}, pages = {39 -- 54}, year = {2022}, abstract = {Arctic coasts are vulnerable to the effects of climate change, including rising sea levels and the loss of permafrost, sea ice and glaciers. Assessing the influence of anthropogenic warming on Arctic coastal dynamics, however, is challenged by the limited availability of observational, oceanographic and environmental data. Yet, with the majority of permafrost coasts being erosive, coupled with projected intensification of erosion and flooding, understanding these changes is critical. In this Review, we describe the morphological diversity of Arctic coasts, discuss important drivers of coastal change, explain the specific sensitivity of Arctic coasts to climate change and provide an overview of pan-Arctic shoreline change and its multifaceted impacts. Arctic coastal changes impact the human environment by threatening coastal settlements, infrastructure, cultural sites and archaeological remains. Changing sediment fluxes also impact the natural environment through carbon, nutrient and pollutant release on a magnitude that remains difficult to predict. Increasing transdisciplinary and interdisciplinary collaboration efforts will build the foundation for identifying sustainable solutions and adaptation strategies to reduce future risks for those living on, working at and visiting the rapidly changing Arctic coast.}, language = {en} } @article{IzotovChisholmWorsecketal.2022, author = {Izotov, Yuri I. and Chisholm, John and Worseck, G{\´a}bor and Guseva, Natalia G. and Schaerer, Daniel and Prochaska, Jason Xavier}, title = {Lyman alpha and Lyman continuum emission of Mg II-selected star-forming galaxies}, series = {Monthly notices of the Royal Astronomical Society}, volume = {515}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stac1899}, pages = {2864 -- 2881}, year = {2022}, abstract = {We present observations with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope of seven compact low-mass star-forming galaxies at redshifts, z, in the range 0.3161-0.4276, with various O3Mg2 = [O III] lambda 5007/Mg II lambda 2796+2803 and Mg-2 = Mg II lambda 2796/Mg II lambda 2803 emission-line ratios. We aim to study the dependence of leaking Lyman continuum (LyC) emission on the characteristics of Mg ii emission together with the dependencies on other indirect indicators of escaping ionizing radiation. LyC emission with escape fractions f(esc)(LyC) = 3.1-4.6 per cent is detected in four galaxies, whereas only 1 sigma upper limits of f(esc)(LyC) in the remaining three galaxies were derived. A strong narrow Ly alpha emission line with two peaks separated by V-sep similar to 298-592 km s(-1) was observed in four galaxies with detected LyC emission and very weak Ly alpha emission is observed in galaxies with LyC non-detections. Our new data confirm the tight anticorrelation between f(esc)(LyC) and V-sep found for previous low-redshift galaxy samples. V-sep remains the best indirect indicator of LyC leakage among all considered indicators. It is found that escaping LyC emission is detected predominantly in galaxies with Mg-2 greater than or similar to 1.3. A tendency of an increase of f(esc)(LyC) with increasing of both the O3Mg2 and Mg-2 is possibly present. However, there is substantial scatter in these relations not allowing their use for reliable prediction of f(esc)(LyC).}, language = {en} } @article{BereswillGatzMillerSuetal.2023, author = {Bereswill, Sarah and Gatz-Miller, Hannah and Su, Danyang and T{\"o}tzke, Christian and Kardjilov, Nikolay and Oswald, Sascha and Mayer, Klaus Ulrich}, title = {Coupling non-invasive imaging and reactive transport modeling to investigate water and oxygen dynamics in the root zone}, series = {Vadose zone journal}, volume = {22}, journal = {Vadose zone journal}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {1539-1663}, doi = {10.1002/vzj2.20268}, pages = {19}, year = {2023}, abstract = {Oxygen (O-2) availability in soils is vital for plant growth and productivity. The transport and consumption of O-2 in the root zone is closely linked to soil moisture content, the spatial distribution of roots, as well as structure and heterogeneity of the surrounding soil. In this study, we measure three-dimensional root system architecture and the spatiotemporal dynamics of soil moisture (\& theta;) and O-2 concentrations in the root zone of maize (Zea mays) via non-invasive imaging, and then construct and parameterize a reactive transport model based on the experimental data. The combination of three non-invasive imaging methods allowed for a direct comparison of simulation results with observations at high spatial and temporal resolution. In three different modeling scenarios, we investigated how the results obtained for different levels of conceptual complexity in the model were able to match measured \& theta; and O-2 concentration patterns. We found that the modeling scenario that considers heterogeneous soil structure and spatial variability of hydraulic parameters (permeability, porosity, and van Genuchten \& alpha; and n), better reproduced the measured \& theta; and O-2 patterns relative to a simple model with a homogenous soil domain. The results from our combined imaging and modeling analysis reveal that experimental O-2 and water dynamics can be reproduced quantitatively in a reactive transport model, and that O-2 and water dynamics are best characterized when conditions unique to the specific system beyond the distribution of roots, such as soil structure and its effect on water saturation and macroscopic gas transport pathways, are considered.}, language = {en} } @article{VitaglianoHameedJiangetal.2023, author = {Vitagliano, Gerardo and Hameed, Mazhar and Jiang, Lan and Reisener, Lucas and Wu, Eugene and Naumann, Felix}, title = {Pollock: a data loading benchmark}, series = {Proceedings of the VLDB Endowment}, volume = {16}, journal = {Proceedings of the VLDB Endowment}, number = {8}, publisher = {Association for Computing Machinery}, address = {New York}, issn = {2150-8097}, doi = {10.14778/3594512.3594518}, pages = {1870 -- 1882}, year = {2023}, abstract = {Any system at play in a data-driven project has a fundamental requirement: the ability to load data. The de-facto standard format to distribute and consume raw data is CSV. Yet, the plain text and flexible nature of this format make such files often difficult to parse and correctly load their content, requiring cumbersome data preparation steps. We propose a benchmark to assess the robustness of systems in loading data from non-standard CSV formats and with structural inconsistencies. First, we formalize a model to describe the issues that affect real-world files and use it to derive a systematic lpollutionz process to generate dialects for any given grammar. Our benchmark leverages the pollution framework for the csv format. To guide pollution, we have surveyed thousands of real-world, publicly available csv files, recording the problems we encountered. We demonstrate the applicability of our benchmark by testing and scoring 16 different systems: popular csv parsing frameworks, relational database tools, spreadsheet systems, and a data visualization tool.}, language = {en} } @inproceedings{YaelLapidotTzuberi2022, author = {Yael, Attia and Lapidot, Elad and Tzuberi, Hannah}, title = {60 Years after the Algerian War}, publisher = {Katholische Akademie Berlin}, address = {Berlin}, year = {2022}, abstract = {Over the six decades since it officially ended, the Algerian War has become a key event for marking, retrospectively, the beginning of a new era in European, Western and global history. This new era is characterized by the proclaimed end of Western hegemony - by the proclaimed end of European history as global, universal history. This era, our era, understands itself as the time after the domination of the West, a time or multiple times of "post": the time of postcolonialism, but also postmodernity, postsecularism, posthumanism. The times of "post" are characterized by a fundamental reconfiguration of the relations between European civilization and its Others, first and foremost by the proclaimed split between Europe and its Others, and more generally by the disintegration, disruption and dispersion of the - allegedly - unified space of culture, knowledge and discourse. The postcolonial era is an era of diversity and difference, an era of dispersions and diasporas, where the space of culture is a space of multiple cultures, a space of in-between, of "inter": the space of the intercultural, but also the interreligious, interethnic, interracial and inter-epistemic. This conference will reflect on the "inter" in the time of "post". We invited scholars, thinkers, intellectuals and artists to discuss various aspects and models of intercultural dynamics that have been developed and articulated in the aftermath of the Algerian War or of other events that marked the decline of Western hegemony, such as the Second Vatican, May 1968 or the Vietnam War. How did the age of decolonization reshape the discourse and practice of intercultural relations? To what extent interculturality itself is a sign or a site of decolonization? To what extent, on the contrary, intercultural relations may reproduce colonial or generate neocolonial patterns? Contributions examine the emergence of intercultural notions and practices in various intellectual traditions, European or non-European; the development of new categories and constellations of identity, otherness and dialogue; the interrelations between epistemic, cultural, discursive, religious and political aspects; as well as reactions to these new developments and various forms of critique and resistance. We are especially interested in how this reflection may shed light on socio-political and cultural phenomena, trends and concerns of the present time.}, language = {en} }