@article{HusemannWorseckBattaiaetal.2018, author = {Husemann, Bernd and Worseck, Gabor and Battaia, Fabrizio Arrigoni and Shanks, T.}, title = {Discovery of a dual AGN at z similar or equal to 3.3 with 20 kpc separation}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {610}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201732457}, pages = {5}, year = {2018}, abstract = {A prediction of the current paradigm of the hierarchical assembly of galaxies is the presence of supermassive dual black holes at separations of a few kpc or less. In this context, we report the detection of a narrow-line emitter within the extended Ly alpha nebula (similar to 120 kpc diameter) of the luminous radio-quiet quasi-stellar object (QSO) LBQS 0302 0019 at z = 3 : 286. We identify several high-ionization narrow emission lines (He II, C IV, C III) associated with this point-like source, which we have named "Jil", which is only similar to 20 kpc (2 : 0 0 9) away from the QSO in projection. Emission-line diagnostics confirm that the source is likely powered by photoionization of an obscured active galactic nucleus (AGN) three orders of magnitude fainter than the QSO. The system represents the tightest unobscured/obscured dual AGN currently known at z > 3, highlighting the power of MUSE to detect these elusive systems.}, language = {en} } @article{LopukhinaLaurinavichyuteLopukhinetal.2018, author = {Lopukhina, Anastasiya and Laurinavichyute, Anna and Lopukhin, Konstantin and Dragoy, Olga V.}, title = {The Mental Representation of Polysemy across Word Classes}, series = {Frontiers in psychology}, volume = {9}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2018.00192}, pages = {16}, year = {2018}, abstract = {Experimental studies on polysemy have come to contradictory conclusions on whether words with multiple senses are stored as separate or shared mental representations. The present study examined the semantic relatedness and semantic similarity of literal and non-literal (metonymic and metaphorical) senses of three word classes: nouns, verbs, and adjectives. Two methods were used: a psycholinguistic experiment and a distributional analysis of corpus data. In the experiment, participants were presented with 6-12 short phrases containing a polysemous word in literal, metonymic, or metaphorical senses and were asked to classify them so that phrases with the same perceived sense were grouped together. To investigate the impact of professional background on their decisions, participants were controlled for linguistic vs. non-linguistic education. For nouns and verbs, all participants preferred to group together phrases with literal and metonymic senses, but not any other pairs of senses. For adjectives, two pairs of senses were often grouped together: literal with metonymic, and metonymic with metaphorical. Participants with a linguistic background were more accurate than participants with non-linguistic backgrounds, although both groups shared principal patterns of sense classification. For the distributional analysis of corpus data, we used a semantic vector approach to quantify the similarity of phrases with literal, metonymic, and metaphorical senses in the corpora. We found that phrases with literal and metonymic senses had the highest degree of similarity for the three word classes, and that metonymic and metaphorical senses of adjectives had the highest degree of similarity among all word classes. These findings are in line with the experimental results. Overall, the results suggest that the mental representation of a polysemous word depends on its word class. In nouns and verbs, literal and metonymic senses are stored together, while metaphorical senses are stored separately; in adjectives, metonymic senses significantly overlap with both literal and metaphorical senses.}, language = {en} } @article{HeinzeHanschenWiesnerReinholdetal.2018, author = {Heinze, Mandy and Hanschen, Franziska S. and Wiesner-Reinhold, Melanie and Baldermann, Susanne and Gr{\"a}fe, Jan and Schreiner, Monika and Neugart, Susanne}, title = {Effects of Developmental Stages and Reduced UVB and Low UV Conditions on Plant Secondary Metabolite Profiles in Pak Choi (Brassica rapa subsp chinensis)}, series = {Journal of agricultural and food chemistry : a publication of the American Chemical Society}, volume = {66}, journal = {Journal of agricultural and food chemistry : a publication of the American Chemical Society}, number = {7}, publisher = {American Chemical Society}, address = {Washington}, issn = {0021-8561}, doi = {10.1021/acs.jafc.7b03996}, pages = {1678 -- 1692}, year = {2018}, abstract = {Pak choi (Brassica rapa subsp. chinensis) is rich in secondary metabolites and contains numerous antioxidants, including flavonoids; hydroxycinnamic acids; carotenoids; chlorophylls; and glucosinolates, which can be hydrolyzed to epithionitriles, nitriles, or isothiocyanates. Here, we investigate the effect of reduced exposure to ultraviolet B (UVB) and UV (UVA and UVB) light at four different developmental stages of pak choi. We found that both the plant morphology and secondary metabolite profiles were affected by reduced exposure to UVB and UV, depending on the plant's developmental stage. In detail, mature 15- and 30-leaf plants had higher concentrations of flavonoids, hydroxycinnamic acids, carotenoids, and chlorophylls, whereas sprouts contained high concentrations of glucosinolates and their hydrolysis products. Dry weights and leaf areas increased as a result of reduced UVB and low UV. For the flavonoids and hydroxycinnamic acids in 30-leaf plants, less complex compounds were favored, for example, sinapic acid acylated kaempferol triglycoside instead of the corresponding tetraglycoside. Moreover, also in 30-leaf plants, zeaxanthin, a carotenoid linked to protection during photosynthesis, was increased under low UV conditions. Interestingly, most glucosinolates were not affected by reduced UVB and low UV conditions. However, this study underlines the importance of 4-(methylsulfinyl)butyl glucosinolate in response to UVA and UVB exposure. Further, reduced UVB and low UV conditions resulted in higher concentrations of glucosinolate-derived nitriles. In conclusion, exposure to low doses of UVB and UV from the early to late developmental stages did not result in overall lower concentrations of plant secondary metabolites.}, language = {en} } @article{FischerMayerSchollImholtetal.2018, author = {Fischer, Stefan and Mayer-Scholl, Anne and Imholt, Christian and Spierling, Nastasja G. and Heuser, Elisa and Schmidt, Sabrina and Reil, Daniela and Rosenfeld, Ulrike and Jacob, Jens and N{\"o}ckler, Karsten and Ulrich, Rainer G.}, title = {Leptospira genomospecies and sequence type prevalence in small mammal populations in Germany}, series = {Vector-Borne and Zoonotic Diseases}, volume = {18}, journal = {Vector-Borne and Zoonotic Diseases}, number = {4}, publisher = {Liebert}, address = {New Rochelle}, issn = {1530-3667}, doi = {10.1089/vbz.2017.2140}, pages = {188 -- 199}, year = {2018}, abstract = {Leptospirosis is a worldwide emerging infectious disease caused by zoonotic bacteria of the genus Leptospira. Numerous mammals, including domestic and companion animals, can be infected by Leptospira spp., but rodents and other small mammals are considered the main reservoir. The annual number of recorded human leptospirosis cases in Germany (2001-2016) was 25-166. Field fever outbreaks in strawberry pickers, due to infection with Leptospira kirschneri serovar Grippotyphosa, were reported in 2007 and 2014. To identify the most commonly occurring Leptospira genomospecies, sequence types (STs), and their small mammal host specificity, a monitoring study was performed during 2010-2014 in four federal states of Germany. Initial screening of kidney tissues of 3,950 animals by PCR targeting the lipl32 gene revealed 435 rodents of 6 species and 89 shrews of three species positive for leptospiral DNA. PCR-based analyses resulted in the identification of the genomospecies L. kirschneri (62.7\%), Leptospira interrogans (28.3\%), and Leptospira borgpetersenii (9.0\%), which are represented by four, one, and two STs, respectively. The average Leptospira prevalence was highest (approximate to 30\%) in common voles (Microtus arvalis) and field voles (Microtus agrestis). Both species were exclusively infected with L. kirschneri. In contrast, in bank voles (Myodes glareolus) and yellow-necked mice (Apodemus flavicollis), DNA of all three genomospecies was detected, and in common shrews (Sorex araneus) DNA of L. kirschneri and L. borgpetersenii was identified. The association between individual infection status and demographic factors varied between species; infection status was always positively correlated to body weight. In conclusion, the study confirmed a broad geographical distribution of Leptospira in small mammals and suggested an important public health relevance of common and field voles as reservoirs of L. kirschneri. Furthermore, the investigations identified seasonal, habitat-related, as well as individual influences on Leptospira prevalence in small mammals that might impact public health.}, language = {en} } @article{XiongFangOsipovetal.2018, author = {Xiong, Hui and Fang, Li and Osipov, Timur and Kling, Nora G. and Wolf, Thomas J. A. and Sistrunk, Emily and Obaid, Razib and G{\"u}hr, Markus and Berrah, Nora}, title = {Fragmentation of endohedral fullerene Ho3N@C-80 in an intense femtosecond near-infrared laser field}, series = {Physical review : A, Atomic, molecular, and optical physics}, volume = {97}, journal = {Physical review : A, Atomic, molecular, and optical physics}, number = {2}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9926}, doi = {10.1103/PhysRevA.97.023419}, pages = {7}, year = {2018}, abstract = {The fragmentation of gas phase endohedral fullerene, Ho3N@C-80, was investigated using femtosecond near-infrared laser pulses with an ion velocity map imaging spectrometer. We observed that Ho+ abundance associated with carbon cage opening dominates at an intensity of 1.1 x 10(14) W/cm(2). As the intensity increases, the Ho+ yield associated with multifragmentation of the carbon cage exceeds the prominence of Ho+ associated with the gentler carbon cage opening. Moreover, the power law dependence of Ho+ on laser intensity indicates that the transition of the most likely fragmentation mechanisms occurs around 2.0 x 10(14) W/cm(2).}, language = {en} } @article{TotzEliseevPetrietal.2018, author = {Totz, Sonja Juliana and Eliseev, Alexey V. and Petri, Stefan and Flechsig, Michael and Caesar, Levke and Petoukhov, Vladimir and Coumou, Dim}, title = {The dynamical core of the Aeolus 1.0 statistical-dynamical atmosphere model}, series = {Geoscientific model development : an interactive open access journal of the European Geosciences Union}, volume = {11}, journal = {Geoscientific model development : an interactive open access journal of the European Geosciences Union}, number = {2}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1991-959X}, doi = {10.5194/gmd-11-665-2018}, pages = {665 -- 679}, year = {2018}, abstract = {Here, we present novel equations for the large-scale zonal-mean wind as well as those for planetary waves. Together with synoptic parameterization (as presented by Coumou et al., 2011), these form the mathematical description of the dynamical core of Aeolus 1.0. The regions of high azonal wind velocities (planetary waves) are accurately captured for all validation experiments. The zonal-mean zonal wind and the integrated lower troposphere mass flux show good results in particular in the Northern Hemisphere. In the Southern Hemisphere, the model tends to produce too-weak zonal-mean zonal winds and a too-narrow Hadley circulation. We discuss possible reasons for these model biases as well as planned future model improvements and applications.}, language = {en} } @article{ParkKrauseKarnahletal.2018, author = {Park, Misoon and Krause, Cornelia and Karnahl, Matthias and Reichardt, Ilka and El Kasmi, Farid and Mayer, Ulrike and Stierhof, York-Dieter and Hiller, Ulrike and Strompen, Georg and Bayer, Martin and Kientz, Marika and Sato, Masa H. and Nishimura, Marc T. and Dangl, Jeffery L. and Sanderfoot, Anton A. and J{\"u}rgens, Gerd}, title = {Concerted Action of Evolutionarily Ancient and Novel SNARE Complexes in Flowering-Plant Cytokinesis}, series = {Developmental cell}, volume = {44}, journal = {Developmental cell}, number = {4}, publisher = {Cell Press}, address = {Cambridge}, issn = {1534-5807}, doi = {10.1016/j.devcel.2017.12.027}, pages = {500 -- +}, year = {2018}, abstract = {Membrane vesicles delivered to the cell-division plane fuse with one another to form the partitioning membrane during plant cytokinesis, starting in the cell center. In Arabidopsis, this requires SNARE complexes involving the cytokinesis-specific Qa-SNARE KNOLLE. However, cytokinesis still occurs in knolle mutant embryos, suggesting contributions from KNOLLE-independent SNARE complexes. Here we show that Qa-SNARE SYP132, having counterparts in lower plants, functionally overlaps with the flowering plant-specific KNOLLE. SYP132 mutation causes cytokinesis defects, knolle syp132 double mutants consist of only one or a few multi-nucleate cells, and SYP132 has the same SNARE partners as KNOLLE. SYP132 and KNOLLE also have non-overlapping functions in secretion and in cellularization of the embryo-nourishing endosperm resulting from double fertilization unique to flowering plants. Evolutionarily ancient non-specialized SNARE complexes originating in algae were thus amended by the appearance of cytokinesis-specific SNARE complexes, meeting the high demand for membrane-fusion capacity during endosperm cellularization in angiosperms.}, language = {en} } @article{RibarHuberSmialeketal.2018, author = {Ribar, Anita and Huber, Stefan E. and Smialek, Malgorzata A. and Tanzer, Katrin and Neustetter, Michael and Sch{\"u}rmann, Robin and Bald, Ilko and Denifl, Stephan}, title = {Hydroperoxyl radical and formic acid formation from common DNA stabilizers upon low energy electron attachment}, series = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, volume = {20}, journal = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, number = {8}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/c7cp07697e}, pages = {5578 -- 5585}, year = {2018}, abstract = {2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) and ethylenediaminetetraacetic acid ( EDTA) are key components of biological buffers and are frequently used as DNA stabilizers in irradiation studies. Such surface or liquid phase studies are done with the aim to understand the fundamental mechanisms of DNA radiation damage and to improve cancer radiotherapy. When ionizing radiation is used, abundant secondary electrons are formed during the irradiation process, which are able to attach to the molecular compounds present on the surface. In the present study we experimentally investigate low energy electron attachment to TRIS and methyliminodiacetic acid ( MIDA), an analogue of EDTA, supported by quantum chemical calculations. The most prominent dissociation channel for TRIS is through hydroperoxyl radical formation, whereas the dissociation of MIDA results in the formation of formic and acetic acid. These compounds are well-known to cause DNA modifications, like strand breaks. The present results indicate that buffer compounds may not have an exclusive protecting effect on DNA as suggested previously.}, language = {en} } @article{JantzKlenkLarsenetal.2018, author = {Jantz, Bastian and Klenk, Tanja and Larsen, Flemming and Wiggan, Jay}, title = {Marketization and Varieties of Accountability Relationships in Employment Services}, series = {Administration \& society}, volume = {50}, journal = {Administration \& society}, number = {3}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0095-3997}, doi = {10.1177/0095399715581622}, pages = {321 -- 345}, year = {2018}, abstract = {In the past decade, European countries have contracted out public employment service functions to activate working-age benefit clients. There has been limited discussion of how contracting out shapes the accountability of employment services or is shaped by alternative democratic, administrative, or network forms of accountability. This article examines employment service accountability in Germany, Denmark, and Great Britain. We find that market accountability instruments are additional instruments, not replacements. The findings highlight the importance of administrative and political instruments in legitimizing marketized service provision and shed light on the processes that lead to the development of a hybrid accountability model.}, language = {en} } @article{GutbierSchoenrockEhrleretal.2018, author = {Gutbier, Birgitt and Sch{\"o}nrock, Stefanie M. and Ehrler, Carolin and Haberberger, Rainer and Dietert, Kristina and Gruber, Achim D. and Kummer, Wolfgang and Michalick, Laura and Kuebler, Wolfgang M. and Hocke, Andreas C. and Szymanski, Kolja and Letsiou, Eleftheria and L{\"u}th, Anja and Schumacher, Fabian and Kleuser, Burkhard and Mitchell, Timothy J. and Bertrams, Wilhelm and Schmeck, Bernd and Treue, Denise and Klauschen, Frederick and Bauer, Torsten T. and T{\"o}nnies, Mario and Weissmann, Norbert and Hippenstiel, Stefan and Suttorp, Norbert and Witzenrath, Martin}, title = {Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2}, series = {Critical care medicine}, volume = {46}, journal = {Critical care medicine}, number = {3}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, organization = {CAPNETZ Study Grp}, issn = {0090-3493}, doi = {10.1097/CCM.0000000000002916}, pages = {e258 -- e267}, year = {2018}, abstract = {Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses. However, the role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia. Design: Controlled, in vitro, ex vivo, and in vivo laboratory study. Subjects: Female wild-type and SphK1-deficient mice, 8-10 weeks old. Human postmortem lung tissue, human blood-derived macrophages, and pulmonary microvascular endothelial cells. Interventions: Wild-type and SphK1-deficient mice were infected with Streptococcus pneumoniae. Pulmonary sphingosine-1-phosphate levels, messenger RNA expression, and permeability as well as lung morphology were analyzed. Human blood-derived macrophages and human pulmonary microvascular endothelial cells were infected with S. pneumoniae. Transcellular electrical resistance of human pulmonary microvascular endothelial cell monolayers was examined. Further, permeability of murine isolated perfused lungs was determined following exposition to sphingosine-1-phosphate and pneumolysin. Measurements and Main Results: Following S. pneumoniae infection, murine pulmonary sphingosine-1-phosphate levels and sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 expression were increased. Pneumonia-induced lung hyperpermeability was reduced in SphK1(-/-) mice compared with wild-type mice. Expression of sphingosine kinase 1 in macrophages recruited to inflamed lung areas in pneumonia was observed in murine and human lungs. S. pneumoniae induced the sphingosine kinase 1/sphingosine-1-phosphate system in blood-derived macrophages and enhanced sphingosine-1-phosphate receptor 2 expression in human pulmonary microvascular endothelial cell in vitro. In isolated mouse lungs, pneumolysin-induced hyperpermeability was dose dependently and synergistically increased by sphingosine-1-phosphate. This sphingosine-1-phosphate-induced increase was reduced by inhibition of sphingosine-1-phosphate receptor 2 or its downstream effector Rho-kinase. Conclusions: Our data suggest that targeting the sphingosine kinase 1-/sphingosine-1-phosphate-/sphingosine-1-phosphate receptor 2-signaling pathway in the lung may provide a novel therapeutic perspective in pneumococcal pneumonia for prevention of acute lung injury.}, language = {en} } @article{GoslingJulierAduBreduetal.2018, author = {Gosling, William D. and Julier, Adele C. M. and Adu-Bredu, Stephen and Djagbletey, Gloria D. and Fraser, Wesley T. and Jardine, Phillip E. and Lomax, Barry H. and Malhi, Yadvinder and Manu, Emmanuel A. and Mayle, Francis E. and Moore, Sam}, title = {Pollen-vegetation richness and diversity relationships in the tropics}, series = {Vegetation History and Archaeobotany}, volume = {27}, journal = {Vegetation History and Archaeobotany}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0939-6314}, doi = {10.1007/s00334-017-0642-y}, pages = {411 -- 418}, year = {2018}, abstract = {Tracking changes in biodiversity through time requires an understanding of the relationship between modern diversity and how this diversity is preserved in the fossil record. Fossil pollen is one way in which past vegetation diversity can be reconstructed. However, there is limited understanding of modern pollen-vegetation diversity relationships from biodiverse tropical ecosystems. Here, pollen (palynological) richness and diversity (Hill N (1)) are compared with vegetation richness and diversity from forest and savannah ecosystems in the New World and Old World tropics (Neotropics and Palaeotropics). Modern pollen data were obtained from artificial pollen traps deployed in 1-ha vegetation study plots from which vegetation inventories had been completed in Bolivia and Ghana. Pollen counts were obtained from 15 to 22 traps per plot, and aggregated pollen sums for each plot were > 2,500. The palynological richness/diversity values from the Neotropics were moist evergreen forest = 86/6.8, semi-deciduous dry forest = 111/21.9, wooded savannah = 138/31.5, and from the Palaeotropics wet evergreen forest = 144/28.3, semi-deciduous moist forest = 104/4.4, forest-savannah transition = 121/14.1; the corresponding vegetation richness/diversity was 100/36.7, 80/38.7 and 71/39.4 (Neotropics), and 101/54.8, 87/45.5 and 71/34.5 (Palaeotropics). No consistent relationship was found between palynological richness/diversity, and plot vegetation richness/diversity, due to the differential influence of other factors such as landscape diversity, pollination strategy, and pollen source area. Palynological richness exceeded vegetation richness, while pollen diversity was lower than vegetation diversity. The relatively high global diversity of tropical vegetation was found to be reflected in the pollen rain.}, language = {en} } @article{TianCaoDallmeyeretal.2018, author = {Tian, Fang and Cao, Xianyong and Dallmeyer, Anne and Lohmann, Gerrit and Zhang, Xu and Ni, Jian and Andreev, Andrei and Anderson, Patricia M. and Lozhkin, Anatoly V. and Bezrukova, Elena and Rudaya, Natalia and Xu, Qinghai and Herzschuh, Ulrike}, title = {Biome changes and their inferred climatic drivers in northern and eastern continental Asia at selected times since 40 cal ka BP}, series = {Vegetation History and Archaeobotany}, volume = {27}, journal = {Vegetation History and Archaeobotany}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0939-6314}, doi = {10.1007/s00334-017-0653-8}, pages = {365 -- 379}, year = {2018}, abstract = {Recent global warming is pronounced in high-latitude regions (e.g. northern Asia), and will cause the vegetation to change. Future vegetation trends (e.g. the "arctic greening") will feed back into atmospheric circulation and the global climate system. Understanding the nature and causes of past vegetation changes is important for predicting the composition and distribution of future vegetation communities. Fossil pollen records from 468 sites in northern and eastern Asia were biomised at selected times between 40 cal ka bp and today. Biomes were also simulated using a climate-driven biome model and results from the two approaches compared in order to help understand the mechanisms behind the observed vegetation changes. The consistent biome results inferred by both approaches reveal that long-term and broad-scale vegetation patterns reflect global- to hemispheric-scale climate changes. Forest biomes increase around the beginning of the late deglaciation, become more widespread during the early and middle Holocene, and decrease in the late Holocene in fringe areas of the Asian Summer Monsoon. At the southern and southwestern margins of the taiga, forest increases in the early Holocene and shows notable species succession, which may have been caused by winter warming at ca. 7 cal ka bp. At the northeastern taiga margin (central Yakutia and northeastern Siberia), shrub expansion during the last deglaciation appears to prevent the permafrost from thawing and hinders the northward expansion of evergreen needle-leaved species until ca. 7 cal ka bp. The vegetation-climate disequilibrium during the early Holocene in the taiga-tundra transition zone suggests that projected climate warming will not cause a northward expansion of evergreen needle-leaved species.}, language = {en} } @article{AertsBotzenClarkeetal.2018, author = {Aerts, J. C. J. H. and Botzen, W. J. Wouter and Clarke, K. C. and Cutter, S. L. and Hall, J. W. and Merz, Bruno and Michel-Kerjan, E. and Mysiak, J. and Surminski, Swenja and Kunreuther, H.}, title = {Integrating human behaviour dynamics into flood disaster risk assessment}, series = {Nature climate change}, volume = {8}, journal = {Nature climate change}, number = {3}, publisher = {Nature Publ. Group}, address = {London}, issn = {1758-678X}, doi = {10.1038/s41558-018-0085-1}, pages = {193 -- 199}, year = {2018}, abstract = {The behaviour of individuals, businesses, and government entities before, during, and immediately after a disaster can dramatically affect the impact and recovery time. However, existing risk-assessment methods rarely include this critical factor. In this Perspective, we show why this is a concern, and demonstrate that although initial efforts have inevitably represented human behaviour in limited terms, innovations in flood-risk assessment that integrate societal behaviour and behavioural adaptation dynamics into such quantifications may lead to more accurate characterization of risks and improved assessment of the effectiveness of risk-management strategies and investments. Such multidisciplinary approaches can inform flood-risk management policy development.}, language = {en} } @article{KetenogluSpiekermannHarderetal.2018, author = {Ketenoglu, Didem and Spiekermann, Georg and Harder, Manuel and Oz, Erdinc and Koz, Cevriye and Yagci, Mehmet C. and Yilmaz, Eda and Yin, Zhong and Sahle, Christoph J. and Detlefs, Blanka and Yavas, Hasan}, title = {X-ray Raman spectroscopy of lithium-ion battery electrolyte solutions in a flow cell}, series = {Journal of synchrotron radiation}, volume = {25}, journal = {Journal of synchrotron radiation}, publisher = {International Union of Crystallography}, address = {Chester}, issn = {0909-0495}, doi = {10.1107/S1600577518001662}, pages = {537 -- 542}, year = {2018}, abstract = {The effects of varying LiPF6 salt concentration and the presence of lithium bis(oxalate)borate additive on the electronic structure of commonly used lithium-ion battery electrolyte solvents (ethylene carbonate-dimethyl carbonate and propylene carbonate) have been investigated. X-ray Raman scattering spectroscopy (a non-resonant inelastic X-ray scattering method) was utilized together with a closed-circle flow cell. Carbon and oxygen K-edges provide characteristic information on the electronic structure of the electrolyte solutions, which are sensitive to local chemistry. Higher Li+ ion concentration in the solvent manifests itself as a blue-shift of both the pi* feature in the carbon edge and the carbonyl pi* feature in the oxygen edge. While these oxygen K-edge results agree with previous soft X-ray absorption studies on LiBF4 salt concentration in propylene carbonate, carbon K-edge spectra reveal a shift in energy, which can be explained with differing ionic conductivities of the electrolyte solutions.}, language = {en} } @article{KellerPinchoverPogorzelski2018, author = {Keller, Matthias and Pinchover, Yehuda and Pogorzelski, Felix}, title = {Optimal Hardy inequalities for Schrodinger operators on graphs}, series = {Communications in mathematical physics}, volume = {358}, journal = {Communications in mathematical physics}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0010-3616}, doi = {10.1007/s00220-018-3107-y}, pages = {767 -- 790}, year = {2018}, abstract = {For a given subcritical discrete Schrodinger operator H on a weighted infinite graph X, we construct a Hardy-weight w which is optimal in the following sense. The operator H - lambda w is subcritical in X for all lambda < 1, null-critical in X for lambda = 1, and supercritical near any neighborhood of infinity in X for any lambda > 1. Our results rely on a criticality theory for Schrodinger operators on general weighted graphs.}, language = {en} } @article{HolzloehnerButzeMaieretal.2018, author = {Holzl{\"o}hner, Pamela and Butze, Monique and Maier, Natalia and Hebel, Nicole and Schliebs, Erik and Micheel, Burkhard and Fuener, Jonas and Heidicke, Gabriele and Hanack, Katja}, title = {Generation of murine monoclonal antibodies with specificity against conventional camelid IgG1 and heavy-chain only IgG2/3}, series = {Veterinary Immunology and Immunopathology}, volume = {197}, journal = {Veterinary Immunology and Immunopathology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0165-2427}, doi = {10.1016/j.vetimm.2018.01.006}, pages = {1 -- 6}, year = {2018}, abstract = {Camelids possess antibodies with a conventional four-chain structure consisting of two heavy and two light chains (of subclass IgG1) but further they also generate heavy-chain only antibodies (of subclass IgG2 and 3) which are fully functional in antigen binding. In this study subclass-specific murine monoclonal antibodies specific to conventional camelid IgG1 and heavy-chain only IgG2/3 were generated and validated for the use as potent secondary detection reagents. The monoclonal antibodies are able to differentiate between all camelid IgGs, conventional four-chain camelid antibodies (of subclass IgG1) and exclusively heavy chain-only antibodies (of subclasses IgG2 and IgG3). Further these antibodies were used to detect specific immune responses after vaccination of Camelids against bovine corona- and rotavirus strains and different E.coli. and Clostridia - antigens and to identify Erysipelothrix rhusiopathiae infected animals within a herd. The described antibodies are suitable as new secondary agents for the detection of different camelid subclasses and the validation of camelid immune reactions.}, language = {en} } @article{DenkerDinevaBalthasaretal.2018, author = {Denker, Carsten and Dineva, Ekaterina Ivanova and Balthasar, Horst and Verma, Meetu and Kuckein, Christoph and Diercke, Andrea and Manrique Gonzalez, Sergio Javier Gonzalez}, title = {Image Quality in High-resolution and High-cadence Solar Imaging}, series = {Solar physics : a journal for solar and solar-stellar research and the study of solar terrestrial physics}, volume = {293}, journal = {Solar physics : a journal for solar and solar-stellar research and the study of solar terrestrial physics}, number = {3}, publisher = {Springer}, address = {Dordrecht}, issn = {0038-0938}, doi = {10.1007/s11207-018-1261-1}, pages = {24}, year = {2018}, abstract = {Broad-band imaging and even imaging with a moderate bandpass (about 1 nm) provides a photon-rich environment, where frame selection (lucky imaging) becomes a helpful tool in image restoration, allowing us to perform a cost-benefit analysis on how to design observing sequences for imaging with high spatial resolution in combination with real-time correction provided by an adaptive optics (AO) system. This study presents high-cadence (160 Hz) G-band and blue continuum image sequences obtained with the High-resolution Fast Imager (HiFI) at the 1.5-meter GREGOR solar telescope, where the speckle-masking technique is used to restore images with nearly diffraction-limited resolution. The HiFI employs two synchronized large-format and high-cadence sCMOS detectors. The median filter gradient similarity (MFGS) image-quality metric is applied, among others, to AO-corrected image sequences of a pore and a small sunspot observed on 2017 June 4 and 5. A small region of interest, which was selected for fast-imaging performance, covered these contrastrich features and their neighborhood, which were part of Active Region NOAA 12661. Modifications of theMFGS algorithm uncover the field-and structure-dependency of this imagequality metric. However, MFGS still remains a good choice for determining image quality without a priori knowledge, which is an important characteristic when classifying the huge number of high-resolution images contained in data archives. In addition, this investigation demonstrates that a fast cadence and millisecond exposure times are still insufficient to reach the coherence time of daytime seeing. Nonetheless, the analysis shows that data acquisition rates exceeding 50 Hz are required to capture a substantial fraction of the best seeing moments, significantly boosting the performance of post-facto image restoration.}, language = {en} } @article{JuangParkKimetal.2018, author = {Juang, Linda P. and Park, Irene and Kim, Su Yeong and Lee, Richard M. and Qin, Desiree and Okazaki, Sumie and Swartz, Teresa Toguchi and Lau, Anna}, title = {Reactive and Proactive Ethnic-Racial Socialization Practices of Second-Generation Asian American Parents}, series = {Asian American journal of psychology}, volume = {9}, journal = {Asian American journal of psychology}, number = {1}, publisher = {American Psychological Association}, address = {Washington}, issn = {1948-1985}, doi = {10.1037/aap0000101}, pages = {4 -- 16}, year = {2018}, abstract = {Studies of Asian American parenting have primarily focused on first-generation immigrant parents. Few studies have examined the experiences of second-generation Asian American adults who now have children of their own. The purpose of this qualitative study, then, is to better understand the values, practices, and concerns of second-generation Asian American parents regarding ethnic and racial socialization. The sample included 34 Asian American parents from seven different cities across the United States. Using interviews and a focus group, the results show that (a) place, specific contexts, and transitions were important to second-generation parents' motivation behind ethnic and racial socialization, (b) parents are reactive and proactive, especially with regard to promoting an awareness of discrimination, in the racial socialization of their children, (c) parents engage in predominantly proactive ethnic socialization when passing on heritage culture, which they believe is important, but also difficult to do, (d) in contrast to ethnic socialization, passing on American culture and passing on important values (that they did not see as solely "American" or "Asian") came easily, and (e) parents consider the intersection of race and culture with religion and disability when socializing their children. Our findings highlight unique aspects of how second-generation Asian American parents engage in ethnic and racial socialization in an increasingly socially diverse world.}, language = {en} } @article{BaushevBarkov2018, author = {Baushev, Anton N. and Barkov, M. V.}, title = {Why does Einasto profile index n similar to 6 occur so frequently?}, series = {Journal of cosmology and astroparticle physics}, journal = {Journal of cosmology and astroparticle physics}, number = {3}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1475-7516}, doi = {10.1088/1475-7516/2018/03/034}, pages = {15}, year = {2018}, abstract = {We consider the behavior of spherically symmetric Einasto halos composed of gravitating particles in the Fokker-Planck approximation. This approach allows us to consider the undesirable influence of close encounters in the N-body simulations more adequately than the generally accepted criteria. The Einasto profile with index n approximate to 6 is a stationary solution of the Fokker-Planck equation in the halo center. There are some reasons to believe that the solution is an attractor. Then the Fokker-Planck diffusion tends to transform a density profile to the equilibrium one with the Einasto index n approximate to 6. We suggest this effect as a possible reason why the Einasto index n approximate to 6 occurs so frequently in the interpretation of N-body simulation results. The results obtained cast doubt on generally accepted criteria of N-body simulation convergence.}, language = {en} } @article{MuellerMartinezValdesStolletal.2018, author = {Mueller, Juliane and Martinez-Valdes, Eduardo Andr{\´e}s and Stoll, Josefine and Mueller, Steffen and Engel, Tilman and Mayer, Frank}, title = {Differences in neuromuscular activity of ankle stabilizing muscles during postural disturbances}, series = {Gait \& posture}, volume = {61}, journal = {Gait \& posture}, publisher = {Elsevier}, address = {Clare}, issn = {0966-6362}, doi = {10.1016/j.gaitpost.2018.01.023}, pages = {226 -- 231}, year = {2018}, abstract = {The purpose was to examine gender differences in ankle stabilizing muscle activation during postural disturbances. Seventeen participants (9 females: 27 +/- 2yrs., 1.69 +/- 0.1 m, 63 +/- 7 kg; 8 males: 29 +/- 2yrs., 1.81 +/- 0.1 m; 83 +/- 7 kg) were included in the study. After familiarization on a split-belt-treadmill, participants walked (1 m/s) while 15 right-sided perturbations were randomly applied 200 ms after initial heel contact. Muscle activity of M. tibialis anterior (TA), peroneus longus (PL) and gastrocnemius medialis (GM) was recorded during unperturbed and perturbed walking. The root mean square (RMS; [\%]) was analyzed within 200 ms after perturbation. Co-activation was quantified as ratio of antagonist (GM)/agonist (TA) EMG-RMS during unperturbed and perturbed walking. Time to onset was calculated (ms). Data were analyzed descriptively (mean +/- SD) followed by three-way-ANOVA (gender/condition/muscle; alpha= 0.05). Perturbed walking elicited higher EMG activity compared to normal walking for TA and PL in both genders (p < 0.000). RMS amplitude gender comparisons revealed an interaction between gender and condition (F = 4.6, p = 0.049) and, a triple interaction among gender, condition and muscle (F = 4.7, p = 0.02). Women presented significantly higher EMG-RMS [\%] PL amplitude than men during perturbed walking (mean difference = 209.6\%, 95\% confidence interval = -367.0 to -52.2\%, p < 0.000). Co-activation showed significant lower values for perturbed compared to normal walking (p < 0.000), without significant gender differences for both walking conditions. GM activated significantly earlier than TA and PL (p < 0.01) without significant differences between the muscle activation onsets of men and women (p = 0.7). The results reflect that activation strategies of the ankle encompassing muscles differ between genders. In provoked stumbling, higher PL EMG activity in women compared to men is present. Future studies should aim to elucidate if this specific behavior has any relationship with ankle injury occurrence between genders.}, language = {en} } @article{LauxErmilovaPannwitzetal.2018, author = {Laux, Eva-Maria and Ermilova, Elena and Pannwitz, Daniel and Gibbons, Jessica and H{\"o}lzel, Ralph and Bier, Frank Fabian}, title = {Dielectric Spectroscopy of Biomolecules up to 110 GHz}, series = {Frequenz}, volume = {72}, journal = {Frequenz}, number = {3-4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0016-1136}, doi = {10.1515/freq-2018-0010}, pages = {135 -- 140}, year = {2018}, abstract = {Radio-frequency fields in the GHz range are increasingly applied in biotechnology and medicine. In order to fully exploit both their potential and their risks detailed information about the dielectric properties of biological material is needed. For this purpose a measuring system is presented that allows the acquisition of complex dielectric spectra over 4 frequency decade up to 110 GHz. Routines for calibration and for data evaluation according to physicochemical interaction models have been developed. The frequency dependent permittivity and dielectric loss of some proteins and nucleic acids, the main classes of biomolecules, and of their sub-units have been determined. Dielectric spectra are presented for the amino acid alanine, the proteins lysozyme and haemoglobin, the nucleotides AMP and ATP, and for the plasmid pET-21, which has been produced by bacterial culture. Characterisation of a variety of biomolecules is envisaged, as is the application to studies on protein structure and function.}, language = {en} } @article{GidionGerhard2018, author = {Gidion, Gunnar and Gerhard, Reimund}, title = {The Bow on a String}, series = {Acta Acustica united with Acustica}, volume = {104}, journal = {Acta Acustica united with Acustica}, number = {2}, publisher = {Hirzel Verlag}, address = {Stuttgart}, issn = {1610-1928}, doi = {10.3813/AAA.919174}, pages = {315 -- 322}, year = {2018}, abstract = {The interaction between a bowed string instrument and its player is conveyed by the bow, the vibrational properties of which can be measured either separately on the bow or during the bowing procedure. Here, two piezoelectric film sensors, made of a ferroelectret material, are installed on a violin bow, one sensor at the tip and one at the frog. With these sensors, a violin is played under normal conditions, and the signals are analysed. The features in the resulting spectrograms are identified as string harmonics and longitudinal bow-hair resonances. The bow-hair sections on both sides of the bow-string contact exhibit separate resonances which are observed as absorption dips in the spectra. Owing to the sensor positions at the bow-hair terminations, it can be inferred that the two bow-hair sections act as mutual vibration absorbers. From a regression of the observed resonances, the longitudinal bow-hair velocity can be obtained. With additional film sensors under the violin bridge, body vibrations were also detected providing further details of the coupling mechanisms.}, language = {en} } @article{TranMaiNguyenetal.2018, author = {Tran, C. T. and Mai, N. T. and Nguyen, V. T. and Nguyen, H. X. and Meharg, A. and Carey, M. and Dultz, S. and Marone, F. and Cichy, Sarah Bettina and Nguyen, Minh N.}, title = {Phytolith-associated potassium in fern}, series = {Soil use and Management}, volume = {34}, journal = {Soil use and Management}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {0266-0032}, doi = {10.1111/sum.12409}, pages = {28 -- 36}, year = {2018}, abstract = {In recent time, phytoliths (silicon deposition between plant cells) have been recognized as an important nutrient source for crops. The work presented here aims at highlighting the potential of phytolith-occluded K pool in ferns. Dicranopteris linearis (D.linearis) is a common fern in the humid subtropical and tropical regions. Burning of the fern D.linearis is, in slash-and-burn regions, a common practice to prepare the soil before planting. We characterised the phytolith-rich ash derived from the fern D.linearis and phytolith-associated potassium (K) (phytK), using X-ray tomographic microscopy in combination with kinetic batch experiments. D.linearis contains up to 3.9g K/kgd.wt, including K subcompartmented in phytoliths. X-ray tomographic microscopy visualized an interembedding structure between organic matter and silica, particularly in leaves. Corelease of K and Si observed in the batch experiments confirmed that the dissolution of ash phytoliths is one of major factors controlling K release. Under heat treatment, a part of the K is made available, while the remainder entrapped into phytoliths (ca. 2.0-3.3\%) is unavailable until the phytoliths are dissolved. By enhanced removal of organic phases, or forming more stable silica phases, heat treatment changes dissolution properties of the phytoliths, affecting K release for crops and soils. The maximum releases of soluble K and Si were observed for the phytoliths treated at 500-800 degrees C. For quantitative approaches for the K provision of plants from the soil phytK pool in soils, factors regulating phytolith dissolution rate have to be considered.}, language = {en} } @article{HolzgrefeLangWellmannHoehleetal.2018, author = {Holzgrefe-Lang, Julia and Wellmann, Caroline and H{\"o}hle, Barbara and Wartenburger, Isabell}, title = {Infants' Processing of Prosodic Cues}, series = {Language and speech}, volume = {61}, journal = {Language and speech}, number = {1}, publisher = {Sage Publ.}, address = {London}, issn = {0023-8309}, doi = {10.1177/0023830917730590}, pages = {153 -- 169}, year = {2018}, abstract = {Infants as young as six months are sensitive to prosodic phrase boundaries marked by three acoustic cues: pitch change, final lengthening, and pause. Behavioral studies suggest that a language-specific weighting of these cues develops during the first year of life; recent work on German revealed that eight-month-olds, unlike six-month-olds, are capable of perceiving a prosodic boundary on the basis of pitch change and final lengthening only. The present study uses Event-Related Potentials (ERPs) to investigate the neuro-cognitive development of prosodic cue perception in German-learning infants. In adults' ERPs, prosodic boundary perception is clearly reflected by the so-called Closure Positive Shift (CPS). To date, there is mixed evidence on whether an infant CPS exists that signals early prosodic cue perception, or whether the CPS emerges only later—the latter implying that infantile brain responses to prosodic boundaries reflect acoustic, low-level pause detection. We presented six- and eight-month-olds with stimuli containing either no boundary cues, only a pitch cue, or a combination of both pitch change and final lengthening. For both age groups, responses to the former two conditions did not differ, while brain responses to prosodic boundaries cued by pitch change and final lengthening showed a positivity that we interpret as a CPS-like infant ERP component. This hints at an early sensitivity to prosodic boundaries that cannot exclusively be based on pause detection. Instead, infants' brain responses indicate an early ability to exploit subtle, relational prosodic cues in speech perception—presumably even earlier than could be concluded from previous behavioral results.}, language = {en} } @article{LehmannEccardScheffleretal.2018, author = {Lehmann, Andreas and Eccard, Jana and Scheffler, Christiane and Kurvers, Ralf H. J. M. and Dammhahn, Melanie}, title = {Under pressure: human adolescents express a pace-of-life syndrome}, series = {Behavioral ecology and sociobiology}, volume = {72}, journal = {Behavioral ecology and sociobiology}, number = {3}, publisher = {Springer}, address = {New York}, issn = {0340-5443}, doi = {10.1007/s00265-018-2465-y}, pages = {15}, year = {2018}, abstract = {The pace-of-life syndrome (POLS) hypothesis posits that life-history characteristics, among individual differences in behavior, and physiological traits have coevolved in response to environmental conditions. This hypothesis has generated much research interest because it provides testable predictions concerning the association between the slow-fast life-history continuum and behavioral and physiological traits. Although humans are among the most well-studied species and similar concepts exist in the human literature, the POLS hypothesis has not yet been directly applied to humans. Therefore, we aimed to (i) test predicted relationships between life history, physiology, and behavior in a human population and (ii) better integrate the POLS hypothesis with other similar concepts. Using data of a representative sample of German adolescents, we extracted maturation status for girls (menarche, n = 791) and boys (voice break, n = 486), and a set of health-related risk-taking behaviors and cardiovascular parameters. Maturation status and health-related risk behavior as well as maturation status and cardiovascular physiology covaried in boys and girls. Fast maturing boys and girls had higher blood pressure and expressed more risk-taking behavior than same-aged slow maturing boys and girls, supporting general predictions of the POLS hypothesis. Only some physiological and behavioral traits were positively correlated, suggesting that behavioral and physiological traits might mediate life-history trade-offs differently. Moreover, some aspects of POLS were sex-specific. Overall, the POLS hypothesis shares many similarities with other conceptual frameworks from the human literature and these concepts should be united more thoroughly to stimulate the study of POLS in humans and other animals. Significance statement The pace-of-life syndrome (POLS) hypothesis suggests that life history, behavioral and physiological traits have coevolved in response to environmental conditions. Here, we tested this link in a representative sample of German adolescents, using data from a large health survey (the KIGGs study) containing information on individual age and state of maturity for girls and boys, and a set of health-related risk-taking behaviors and cardiovascular parameters. We found that fast maturing girls and boys had overall higher blood pressure and expressed more risk-taking behavior than same-aged slow maturing girls and boys. Only some behavioral and physiological traits were positively correlated, suggesting that behavioral and physiological traits might mediate life-history trade-offs differently and not necessarily form a syndrome. Our results demonstrate a general link between life history, physiological and behavioral traits in humans, while simultaneously highlighting a more complex and rich set of relationships, since not all relationships followed predictions by the POLS hypothesis.}, language = {en} } @article{Thewes2018, author = {Thewes, Christoph}, title = {Verzerrte Beteiligung}, series = {K{\"o}lner Zeitschrift f{\"u}r Soziologie und Sozialpsychologie}, volume = {70}, journal = {K{\"o}lner Zeitschrift f{\"u}r Soziologie und Sozialpsychologie}, number = {1}, publisher = {Springer}, address = {Wiesbaden}, issn = {0023-2653}, doi = {10.1007/s11577-018-0514-1}, pages = {53 -- 86}, year = {2018}, abstract = {Die Beteiligung von B{\"u}rgern abseits der institutionell geregelten Wahlen gilt vermehrt als Allheilmittel gegen die Erosion b{\"u}rgerschaftlichen Engagements. Eine Vielzahl von Autoren haben auf den Missstand aufmerksam gemacht, dass Beteiligung abseits von Wahlen nur von wenigen, oftmals privilegierten Personen genutzt wird, die Beteiligung demnach verzerrt sei. Dieser Artikel nimmt als erster sowohl die ungleiche Beteiligung als auch die Verzerrung eines konkreten Abstimmungsergebnisses in den Blick. F{\"u}r den Volksentscheid {\"u}ber das Bauprojekt Stuttgart 21 (S21) aus dem Jahr 2011 wird ein kontrafaktisches Wahlergebnis aller Nichtw{\"a}hler gesch{\"a}tzt. Durch die Verkn{\"u}pfung von Makro-Daten auf Gemeindeebene mit einem Vorhersagemodell auf Individualebene wird der Beteiligungs-Bias gesch{\"a}tzt. Dieser liegt {\"u}ber dem von Wahlen, jedoch niedriger als bei Petitionen und Demonstrationen. Das kontrafaktische Abstimmungsergebnis prognostiziert eine verst{\"a}rkte Ablehnung von S21.}, language = {de} } @article{HeVorogushynUngerShayestehetal.2018, author = {He, Zhihua and Vorogushyn, Sergiy and Unger-Shayesteh, Katy and Gafurov, Abror and Kalashnikova, Olga and Omorova, Elvira and Merz, Bruno}, title = {The Value of Hydrograph Partitioning Curves for Calibrating Hydrological Models in Glacierized Basins}, series = {Water resources research}, volume = {54}, journal = {Water resources research}, number = {3}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0043-1397}, doi = {10.1002/2017WR021966}, pages = {2336 -- 2361}, year = {2018}, abstract = {This study refines the method for calibrating a glacio-hydrological model based on Hydrograph Partitioning Curves (HPCs), and evaluates its value in comparison to multidata set optimization approaches which use glacier mass balance, satellite snow cover images, and discharge. The HPCs are extracted from the observed flow hydrograph using catchment precipitation and temperature gradients. They indicate the periods when the various runoff processes, such as glacier melt or snow melt, dominate the basin hydrograph. The annual cumulative curve of the difference between average daily temperature and melt threshold temperature over the basin, as well as the annual cumulative curve of average daily snowfall on the glacierized areas are used to identify the starting and end dates of snow and glacier ablation periods. Model parameters characterizing different runoff processes are calibrated on different HPCs in a stepwise and iterative way. Results show that the HPC-based method (1) delivers model-internal consistency comparably to the tri-data set calibration method; (2) improves the stability of calibrated parameter values across various calibration periods; and (3) estimates the contributions of runoff components similarly to the tri-data set calibration method. Our findings indicate the potential of the HPC-based approach as an alternative for hydrological model calibration in glacierized basins where other calibration data sets than discharge are often not available or very costly to obtain.}, language = {en} } @article{deAbreueLimaLiWenetal.2018, author = {de Abreu e Lima, Francisco Anastacio and Li, Kun and Wen, Weiwei and Yan, Jianbing and Nikoloski, Zoran and Willmitzer, Lothar and Brotman, Yariv}, title = {Unraveling lipid metabolism in maize with time-resolved multi-omics data}, series = {The plant journal}, volume = {93}, journal = {The plant journal}, number = {6}, publisher = {Wiley}, address = {Hoboken}, issn = {0960-7412}, doi = {10.1111/tpj.13833}, pages = {1102 -- 1115}, year = {2018}, abstract = {Maize is the cereal crop with the highest production worldwide, and its oil is a key energy resource. Improving the quantity and quality of maize oil requires a better understanding of lipid metabolism. To predict the function of maize genes involved in lipid biosynthesis, we assembled transcriptomic and lipidomic data sets from leaves of B73 and the high-oil line By804 in two distinct time-series experiments. The integrative analysis based on high-dimensional regularized regression yielded lipid-transcript associations indirectly validated by Gene Ontology and promoter motif enrichment analyses. The co-localization of lipid-transcript associations using the genetic mapping of lipid traits in leaves and seedlings of a B73 x By804 recombinant inbred line population uncovered 323 genes involved in the metabolism of phospholipids, galactolipids, sulfolipids and glycerolipids. The resulting association network further supported the involvement of 50 gene candidates in modulating levels of representatives from multiple acyl-lipid classes. Therefore, the proposed approach provides high-confidence candidates for experimental testing in maize and model plant species.}, language = {en} } @article{DietrichBehrensWilke2018, author = {Dietrich, Marcel and Behrens, Harald and Wilke, Max}, title = {A new optical cell for in situ Raman spectroscopy, and its application to study sulfur-bearing fluids at elevated pressures and temperatures}, series = {American mineralogist : an international journal of earth and planetary materials}, volume = {103}, journal = {American mineralogist : an international journal of earth and planetary materials}, number = {3}, publisher = {Mineralogical Society of America}, address = {Chantilly}, issn = {0003-004X}, doi = {10.2138/am-2018-6244}, pages = {418 -- 429}, year = {2018}, abstract = {Sulfur is an important component in volcanic gases at the Earth surface but also present in the deep Earth in hydrothermal or magmatic fluids. Little is known about the evolution of such fluids during ascent in the crust. A new optical cell was developed for in situ Raman spectroscopic investigations on fluids allowing abrupt or continuous changes of pressure up to 200 MPa at temperatures up to 750 degrees C. The concept is based on a flexible gold bellow, which separates the sample fluid from the pressure medium water. To avoid reactions between aggressive fluids and the pressure cell, steel components in contact with the fluid are shielded by gold foil. The cell was tested to study redox reactions in fluids using aqueous ammonium sulfate solutions as a model system. During heating at constant pressure of 130 MPa, sulfate ions transform first to HSO4- ions and then to molecular units such as H2SO4. Variation of pressure shows that the stability of sulfate species relies on fluid density, i.e., highly charged species are stable only in high-density fluids. Partial decomposition of ammonium was evident above 550 degrees C by the occurrence of a nitrogen peak in the Raman spectra. Reduced sulfur species were observed above 700 degrees C by Raman signals near 2590 cm(-1) assigned to HS- and H2S. No clear evidence for the formation of sulfur dioxide was found in contrary to previous studies on aqueous H2SO4, suggesting very reducing conditions in our experiments. Fluid-mineral interaction was studied by inserting into the cell a small, semi-open capsule filled with a mixture of pyrite and pyrrhotite. Oxidation of the sample assembly was evident by transformation of pyrite to pyrrhotite. As a consequence, sulfide species were observed in the fluid already at temperatures of similar to 600 degrees C.}, language = {en} } @article{TutuSobolevSteinbergeretal.2018, author = {Tutu, Anthony Osei and Sobolev, Stephan Vladimir and Steinberger, Bernhard and Popov, A. A. and Rogozhina, Irina}, title = {Evaluating the Influence of Plate Boundary Friction and Mantle Viscosity on Plate Velocities}, series = {Geochemistry, geophysics, geosystems}, volume = {19}, journal = {Geochemistry, geophysics, geosystems}, number = {3}, publisher = {American Geophysical Union}, address = {Washington}, issn = {1525-2027}, doi = {10.1002/2017GC007112}, pages = {642 -- 666}, year = {2018}, abstract = {Lithospheric plates move over the low-viscosity asthenosphere balancing several forces, which generate plate motions. We use a global 3-D lithosphere-asthenosphere model (SLIM3D) with visco-elasto-plastic rheology coupled to a spectral model of mantle flow at 300 km depth to quantify the influence of intra-plate friction and asthenospheric viscosity on plate velocities. We account for the brittle-ductile deformation at plate boundaries (yield stress) using a plate boundary friction coefficient to predict the present-day plate motion and net rotation of the lithospheric plates. Previous modeling studies have suggested that small friction coefficients (mu < 0.1, yield stress similar to 100 MPa) can lead to plate tectonics in models of mantle convection. Here we show that in order to match the observed present-day plate motion and net rotation, the frictional parameter must be less than 0.05. We obtain a good fit with the magnitude and orientation of the observed plate velocities (NUVEL-1A) in a no-net-rotation (NNR) reference frame with mu < 0.05 and a minimum asthenosphere viscosity of similar to 5 . 10(19) Pas to 10(20) Pas. Our estimates of net rotation (NR) of the lith-osphere suggest that amplitudes similar to 0.1-0.2 (degrees/Ma), similar to most observation-based estimates, can be obtained with asthenosphere viscosity cutoff values of similar to 10(19) Pas to 5 . 10(19) Pas and friction coefficients mu < 0.05.}, language = {en} } @article{NizardoSchanzenbachSchoenemannetal.2018, author = {Nizardo, Noverra M. and Schanzenbach, Dirk and Sch{\"o}nemann, Eric and Laschewsky, Andre}, title = {Exploring poly(ethylene glycol)-polyzwitterion diblock copolymers as biocompatible smart macrosurfactants featuring UCST-phase behavior in normal saline solution}, series = {Polymers}, volume = {10}, journal = {Polymers}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym10030325}, pages = {22}, year = {2018}, abstract = {Nonionic-zwitterionic diblock copolymers are designed to feature a coil-to-globule collapse transition with an upper critical solution temperature (UCST) in aqueous media, including physiological saline solution. The block copolymers that combine presumably highly biocompatible blocks are synthesized by chain extension of a poly(ethylene glycol) (PEG) macroinitiator via atom transfer radical polymerization (ATRP) of sulfobetaine and sulfabetaine methacrylates. Their thermoresponsive behavior is studied by variable temperature turbidimetry and H-1 NMR spectroscopy. While the polymers with polysulfobetaine blocks exhibit phase transitions in the physiologically interesting window of 30-50 degrees C only in pure aqueous solution, the polymers bearing polysulfabetaine blocks enabled phase transitions only in physiological saline solution. By copolymerizing a pair of structurally closely related sulfo-and sulfabetaine monomers, thermoresponsive behavior can be implemented in aqueous solutions of both low and high salinity. Surprisingly, the presence of the PEG blocks can affect the UCST-transitions of the polyzwitterions notably. In specific cases, this results in "schizophrenic" thermoresponsive behavior displaying simultaneously an UCST and an LCST (lower critical solution temperature) transition. Exploratory experiments on the UCST-transition triggered the encapsulation and release of various solvatochromic fluorescent dyes as model "cargos" failed, apparently due to the poor affinity even of charged organic compounds to the collapsed state of the polyzwitterions.}, language = {en} } @article{FischerSpierlingHeuseretal.2018, author = {Fischer, Stefan and Spierling, Nastasja G. and Heuser, Elisa and Kling, Christopher and Schmidt, Sabrina and Rosenfeld, Ulrike and Reil, Daniela and Imholt, Christian and Jacob, Jens and Ulrich, Rainer G. and Essbauer, Sandra}, title = {High prevalence of Rickettsia helvetica in wild small mammal populations in Germany}, series = {Ticks and Tick-borne Diseases}, volume = {9}, journal = {Ticks and Tick-borne Diseases}, number = {3}, publisher = {Elsevier GMBH}, address = {M{\"u}nchen}, issn = {1877-959X}, doi = {10.1016/j.ttbdis.2018.01.009}, pages = {500 -- 505}, year = {2018}, abstract = {Since the beginning of the 21st century, spotted fever rickettsioses are known as emerging diseases worldwide. Rickettsiae are obligately intracellular bacteria transmitted by arthropod vectors. The ecology of Rickettsia species has not been investigated in detail, but small mammals are considered to play a role as reservoirs. Aim of this study was to monitor rickettsiae in wild small mammals over a period of five years in four federal states of Germany. Initial screening of ear pinna tissues of 3939 animals by Pan-Rick real-time PCR targeting the citrate synthase (gltA) gene revealed 296 rodents of seven species and 19 shrews of two species positive for rickettsial DNA. Outer membrane protein gene (ompB, ompAIV) PCRs based typing resulted in the identification of three species: Rickettsia helvetica (90.9\%) was found as the dominantly occurring species in the four investigated federal states, but Rickettsia felis (7.8\%) and Rickettsia raoultii (1.3\%) were also detected. The prevalence of Rickettsia spp. in rodents of the genus Apodemus was found to be higher (approximately 14\%) than in all other rodent and shrew species at all investigated sites. General linear mixed model analyses indicated that heavier (older) individuals of yellow-necked mice and male common voles seem to contain more often rickettsial DNA than younger ones. Furthermore, rodents generally collected in forests in summer and autumn more often carried rickettsial DNA. In conclusion, this study indicated a high prevalence of R. helvetica in small mammal populations and suggests an age-dependent increase of the DNA prevalence in some of the species and in animals originating from forest habitats. The finding of R. helvetica and R. felis DNA in multiple small mammal species may indicate frequent trans-species transmission by feeding of vectors on different species. Further investigations should target the reason for the discrepancy between the high rickettsial DNA prevalence in rodents and the so far almost absence of clinical apparent human infections.}, language = {en} } @article{SchneiderGuenterTaubert2018, author = {Schneider, Matthias and G{\"u}nter, Christina and Taubert, Andreas}, title = {Co-deposition of a hydrogel/calcium phosphate hybrid layer on 3D printed poly(lactic acid) scaffolds via dip coating}, series = {Polymers}, volume = {10}, journal = {Polymers}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym10030275}, pages = {19}, year = {2018}, abstract = {The article describes the surface modification of 3D printed poly(lactic acid) (PLA) scaffolds with calcium phosphate (CP)/gelatin and CP/chitosan hybrid coating layers. The presence of gelatin or chitosan significantly enhances CP co-deposition and adhesion of the mineral layer on the PLA scaffolds. The hydrogel/CP coating layers are fairly thick and the mineral is a mixture of brushite, octacalcium phosphate, and hydroxyapatite. Mineral formation is uniform throughout the printed architectures and all steps (printing, hydrogel deposition, and mineralization) are in principle amenable to automatization. Overall, the process reported here therefore has a high application potential for the controlled synthesis of biomimetic coatings on polymeric biomaterials.}, language = {en} } @article{TaronLellBarlowetal.2018, author = {Taron, Ulrike H. and Lell, Moritz and Barlow, Axel and Paijmans, Johanna L. A.}, title = {Testing of Alignment Parameters for Ancient Samples}, series = {Genese}, volume = {9}, journal = {Genese}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2073-4425}, doi = {10.3390/genes9030157}, pages = {12}, year = {2018}, abstract = {High-throughput sequence data retrieved from ancient or other degraded samples has led to unprecedented insights into the evolutionary history of many species, but the analysis of such sequences also poses specific computational challenges. The most commonly used approach involves mapping sequence reads to a reference genome. However, this process becomes increasingly challenging with an elevated genetic distance between target and reference or with the presence of contaminant sequences with high sequence similarity to the target species. The evaluation and testing of mapping efficiency and stringency are thus paramount for the reliable identification and analysis of ancient sequences. In this paper, we present 'TAPAS', (Testing of Alignment Parameters for Ancient Samples), a computational tool that enables the systematic testing of mapping tools for ancient data by simulating sequence data reflecting the properties of an ancient dataset and performing test runs using the mapping software and parameter settings of interest. We showcase TAPAS by using it to assess and improve mapping strategy for a degraded sample from a banded linsang (Prionodon linsang), for which no closely related reference is currently available. This enables a 1.8-fold increase of the number of mapped reads without sacrificing mapping specificity. The increase of mapped reads effectively reduces the need for additional sequencing, thus making more economical use of time, resources, and sample material.}, language = {en} } @article{ChenBornhorstAschner2018, author = {Chen, Pan and Bornhorst, Julia and Aschner, Michael}, title = {Manganese metabolism in humans}, series = {Frontiers in Bioscience-Landmark}, volume = {23}, journal = {Frontiers in Bioscience-Landmark}, number = {9}, publisher = {Frontiers in Bioscience INC}, address = {Irvine}, issn = {1093-9946}, doi = {10.2741/4665}, pages = {1655 -- 1679}, year = {2018}, abstract = {Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate carboxylase and Mn superoxide dismutase (Mn-SOD). Through these metalloproteins, Mn plays critically important roles in development, digestion, reproduction, antioxidant defense, energy production, immune response and regulation of neuronal activities. Mn deficiency is rare. In contrast Mn poisoning may be encountered upon overexposure to this metal. Excessive Mn tends to accumulate in the liver, pancreas, bone, kidney and brain, with the latter being the major target of Mn intoxication. Hepatic cirrhosis, polycythemia, hypermanganesemia, dystonia and Parkinsonism-like symptoms have been reported in patients with Mn poisoning. In recent years, Mn has come to the forefront of environmental concerns due to its neurotoxicity. Molecular mechanisms of Mn toxicity include oxidative stress, mitochondrial dysfunction, protein misfolding, endoplasmic reticulum (ER) stress, autophagy dysregulation, apoptosis, and disruption of other metal homeostasis. The mechanisms of Mn homeostasis are not fully understood. Here, we will address recent progress in Mn absorption, distribution and elimination across different tissues, as well as the intracellular regulation of Mn homeostasis in cells. We will conclude with recommendations for future research areas on Mn metabolism.}, language = {en} } @article{Christians2018, author = {Christians, Heiko}, title = {Bei den Bandar-log. Wunderbare Wiederaneignungen}, series = {Merkur : deutsche Zeitschrift f{\"u}r europ{\"a}isches Denken}, volume = {72}, journal = {Merkur : deutsche Zeitschrift f{\"u}r europ{\"a}isches Denken}, number = {826}, publisher = {Klett-Cotta Verlag}, address = {Stuttgart}, issn = {0026-0096}, pages = {79 -- 87}, year = {2018}, language = {de} } @article{ChenHoehle2018, author = {Chen, Aoju and H{\"o}hle, Barbara}, title = {Four- to five-year-old' use of word order and prosody in focus marking in Dutch}, series = {Linguistics Vanguard}, volume = {4}, journal = {Linguistics Vanguard}, publisher = {De Gruyter}, address = {Berlin}, issn = {2199-174X}, doi = {10.1515/lingvan-2016-0101}, pages = {9}, year = {2018}, abstract = {This study investigated Dutch-speaking four- to five-year-olds' use of word order and prosody in distinguishing focus types (broad focus, narrow focus, and contrastive narrow focus) via an interactive answer-reconstruction game. We have found an overall preference for the unmarked word order SVO and no evidence for the use of OVS to distinguish focus types. But the children used pitch and duration in the subject-nouns to distinguish focus types in SVO sentences. These findings show that Dutch-speaking four- to five-year-olds differ from their German- and Finnish-speaking peers, who show evidence of varying choice of word order to mark specific focus types, and use prosody to distinguish focus types in subject and object nouns in both SVO and OVS sentences. These comparisons suggest that typological differences in the relative importance between word order and prosody can lead to differences in children's use of word order and prosody in unmarked and marked word orders. A more equal role of word order and prosody in the ambient language can stimulate more extensive use of prosody in the marked word order, whereas a more limited role of word order can restrict the use of prosody in the unmarked word order.}, language = {en} } @article{Goychuk2018, author = {Goychuk, Igor}, title = {Sensing magnetic fields with magnetosensitive ion channels}, series = {Sensors}, volume = {18}, journal = {Sensors}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s18030728}, pages = {19}, year = {2018}, abstract = {Magnetic nanoparticles are met across many biological species ranging from magnetosensitive bacteria, fishes, bees, bats, rats, birds, to humans. They can be both of biogenetic origin and due to environmental contamination, being either in paramagnetic or ferromagnetic state. The energy of such naturally occurring single-domain magnetic nanoparticles can reach up to 10-20 room k(B)T in the magnetic field of the Earth, which naturally led to supposition that they can serve as sensory elements in various animals. This work explores within a stochastic modeling framework a fascinating hypothesis of magnetosensitive ion channels with magnetic nanoparticles serving as sensory elements, especially, how realistic it is given a highly dissipative viscoelastic interior of living cells and typical sizes of nanoparticles possibly involved.}, language = {en} } @article{FarhanRudolphNoecheletal.2018, author = {Farhan, Muhammad and Rudolph, Tobias and N{\"o}chel, Ulrich and Kratz, Karl and Lendlein, Andreas}, title = {Extractable Free Polymer Chains Enhance Actuation Performance of Crystallizable Poly(epsilon-caprolactone) Networks and Enable Self-Healing}, series = {Polymers}, volume = {10}, journal = {Polymers}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2073-4360}, doi = {10.3390/polym10030255}, pages = {15}, year = {2018}, abstract = {Crosslinking of thermoplastics is a versatile method to create crystallizable polymer networks, which are of high interest for shape-memory actuators. Here, crosslinked poly(epsilon-caprolactone) thermosets (cPCLs) were prepared from linear starting material, whereby the amount of extractable polymer was varied. Fractions of 5-60 wt \% of non-crosslinked polymer chains, which freely interpenetrate the crosslinked network, were achieved leading to differences in the resulting phase of the bulk material. This can be described as "sponge-like" with open or closed compartments depending on the amount of interpenetrating polymer. The crosslinking density and the average network chain length remained in a similar range for all network structures, while the theoretical accessible volume for reptation of the free polymer content is affected. This feature could influence or introduce new functions into the material created by thermomechanical treatment. The effect of interpenetrating PCL in cPCLs on the reversible actuation was analyzed by cyclic, uniaxial tensile tests. Here, high reversible strains of up to Delta epsilon = 24\% showed the enhanced actuation performance of networks with a non-crosslinked PCL content of 30 wt \% resulting from the crystal formation in the phase of the non-crosslinked PCL and co-crystallization with network structures. Additional functionalities are reprogrammability and self-healing capabilities for networks with high contents of extractable polymer enabling reusability and providing durable actuator materials.}, language = {en} } @article{BehrendtSchlaad2018, author = {Behrendt, Felix Nicolas and Schlaad, Helmut}, title = {Entropy-Driven Ring-Opening Disulfide Metathesis Polymerization for the Synthesis of Functional Poly(disulfide)s}, series = {Macromolecular rapid communications}, volume = {39}, journal = {Macromolecular rapid communications}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1022-1336}, doi = {10.1002/marc.201700735}, pages = {4}, year = {2018}, abstract = {Metal-free entropy-driven disulfide metathesis polymerization of unsaturated L-cystine based macrocycles produces high-molar-mass heterofunctional poly(disulfide)s, i.e., poly(ester-disulfide-alkene) and poly(amide-disulfide-alkene); M-w(app) = 44-60 kDa, (sic) > 1.7. The polymerization is fast and reaches equilibrium within 1-5 minutes (monomer conversion 70-90\%) in polar aprotic solvents such as N,N-dimethylacetamide, dimethylsulfoxide, or y-valerolactone. Thiol-terminated polymers are stable in bulk or when dissolved in weakly polar solvents, but rapidly depolymerize in dilute polar solution.}, language = {en} } @article{LeachBeisnerCareyetal.2018, author = {Leach, Taylor H. and Beisner, Beatrix E. and Carey, Cayelan C. and Pernica, Patricia and Rose, Kevin C. and Huot, Yannick and Brentrup, Jennifer A. and Domaizon, Isabelle and Grossart, Hans-Peter and Ibelings, Bastiaan W. and Jacquet, Stephan and Kelly, Patrick T. and Rusak, James A. and Stockwell, Jason D. and Straile, Dietmar and Verburg, Piet}, title = {Patterns and drivers of deep chlorophyll maxima structure in 100 lakes}, series = {Limnology and oceanography}, volume = {63}, journal = {Limnology and oceanography}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {0024-3590}, doi = {10.1002/lno.10656}, pages = {628 -- 646}, year = {2018}, abstract = {The vertical distribution of chlorophyll in stratified lakes and reservoirs frequently exhibits a maximum peak deep in the water column, referred to as the deep chlorophyll maximum (DCM). DCMs are ecologically important hot spots of primary production and nutrient cycling, and their location can determine vertical habitat gradients for primary consumers. Consequently, the drivers of DCM structure regulate many characteristics of aquatic food webs and biogeochemistry. Previous studies have identified light and thermal stratification as important drivers of summer DCM depth, but their relative importance across a broad range of lakes is not well resolved. We analyzed profiles of chlorophyll fluorescence, temperature, and light during summer stratification from 100 lakes in the Global Lake Ecological Observatory Network (GLEON) and quantified two characteristics of DCM structure: depth and thickness. While DCMs do form in oligotrophic lakes, we found that they can also form in eutrophic to dystrophic lakes. Using a random forest algorithm, we assessed the relative importance of variables associated with light attenuation vs. thermal stratification for predicting DCM structure in lakes that spanned broad gradients of morphometry and transparency. Our analyses revealed that light attenuation was a more important predictor of DCM depth than thermal stratification and that DCMs deepen with increasing lake clarity. DCM thickness was best predicted by lake size with larger lakes having thicker DCMs. Additionally, our analysis demonstrates that the relative importance of light and thermal stratification on DCM structure is not uniform across a diversity of lake types.}, language = {en} } @article{OezcanBookhagenMusaoglu2018, author = {{\"O}zcan, Orkan and Bookhagen, Bodo and Musaoglu, Nebiye}, title = {Impact of the Ataturk Dam Lake on Agro-Meteorological Aspects of the Southeastern Anatolia Region, Turkey}, series = {Journal of the Indian Society of Remote Sensing}, volume = {46}, journal = {Journal of the Indian Society of Remote Sensing}, number = {3}, publisher = {Springer}, address = {New York}, issn = {0255-660X}, doi = {10.1007/s12524-017-0703-9}, pages = {471 -- 481}, year = {2018}, abstract = {In this study, the spatial and temporal impacts of the Ataturk Dam on agro-meteorological aspects of the Southeastern Anatolia region have been investigated. Change detection and environmental impacts due to water-reserve changes in Ataturk Dam Lake have been determined and evaluated using multi-temporal Landsat satellite imageries and meteorological datasets within a period of 1984-2011. These time series have been evaluated for three time periods. Dam construction period constitutes the first part of the study. Land cover/use changes especially on agricultural fields under the Ataturk Dam Lake and its vicinity have been identified between the periods of 1984-1992. The second period comprises the 10-year period after the completion of filling up the reservoir in 1992. At this period, Landsat and meteorological time-series analyses are examined to assess the impact of the Ataturk Dam Lake on selected irrigated agricultural areas. For the last 9-year period from 2002 to 2011, the relationships between seasonal water-reserve changes and irrigated plains under changing climatic factors primarily driving vegetation activity (monthly, seasonal, and annual fluctuations of rainfall rate, air temperature, humidity) on the watershed have been investigated using a 30-year meteorological time series. The results showed that approximately 368 km(2) of agricultural fields have been affected because of inundation due to the Ataturk Dam Lake. However, irrigated agricultural fields have been increased by 56.3\% of the total area (1552 of 2756 km(2)) on Harran Plain within the period of 1984-2011.}, language = {en} } @article{FernandezFernandezGranacherSanzRivasetal.2018, author = {Fernandez-Fernandez, Jaime and Granacher, Urs and Sanz-Rivas, David and Sarabia Marin, Jose Manuel and Luis Hernandez-Davo, Jose and Moya, Manuel}, title = {Sequencing Effects of Neuromuscular Training on Physical Fitness in Youth Elite Tennis Players}, series = {Journal of strength and conditioning research : the research journal of the NSCA}, volume = {32}, journal = {Journal of strength and conditioning research : the research journal of the NSCA}, number = {3}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1064-8011}, doi = {10.1519/JSC.0000000000002319}, pages = {849 -- 856}, year = {2018}, abstract = {Fernandez-Fernandez, J, Granacher, U, Sanz-Rivas, D, Sarabia Marin, JM, Hernandez-Davo, JL, and Moya, M. Sequencing effects of neuromuscular training on physical fitness in youth elite tennis players. J Strength Cond Res 32(3): 849-856, 2018-The aim of this study was to analyze the effects of a 5-week neuromuscular training (NMT) implemented before or after a tennis session in prepubertal players on selected components of physical fitness. Sixteen high-level tennis players with a mean age of 12.9 +/- 0.4 years participated in this study, and were assigned to either a training group performing NMT before tennis-specific training (BT; n = 8) or a group that conducted NMT after tennis-specific training (AT; n = 8). Pretest and posttest included: speed (5, 10, and 20 m); modified 5-0-5 agility test; countermovement jump (CMJ); overhead medicine ball throw (MBT); and serve velocity (SV). Results showed that the BT group achieved positive effects from pretest to posttest measures in speed (d = 0.52, 0.32, and 1.08 for 5, 10, and 20 m respectively), 5-0-5 (d = 0.22), CMJ (d = 0.29), MBT (d = 0.51), and SV (d = 0.32), whereas trivial (10 m, 20 m, CMJ, SV, and MBT) or negative effects (d = -0.19 and -0.24 for 5 m and 5-0-5, respectively) were reported for the AT group. The inclusion of an NMT session before the regular tennis training led to positive effects from pretest to posttest measures in performance-related variables (i.e., jump, sprint, change of direction capacity, as well as upper-body power), whereas conducting the same exercise sessions after the regular tennis training was not accompanied by the same improvements.}, language = {en} } @article{Zimmermann2018, author = {Zimmermann, Andreas}, title = {A victory for international rule of law?}, series = {Journal of international criminal justice}, volume = {16}, journal = {Journal of international criminal justice}, number = {1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1478-1387}, doi = {10.1093/jicj/mqy008}, pages = {19 -- 29}, year = {2018}, abstract = {On 14 December 2017, the Assembly of States Parties of the Rome Statute decided to activate the International Criminal Court's jurisdiction over the crime of aggression. In doing so, it however seems to have rescinded the Kampala amendment adopted in 2010, and in particular, the need for State Parties to eventually opt out from the Court's aggression-related jurisdiction. This reversal, while being more in line with the Rome Statute than the Kampala amendment itself, raises new (and old) and challenging legal questions which are highlighted in this article.}, language = {en} } @article{MillerSchwarz2018, author = {Miller, Jeff and Schwarz, Wolfgang}, title = {Implications of Individual Differences in On-Average Null Effects}, series = {Journal of experimental psychology : General}, volume = {147}, journal = {Journal of experimental psychology : General}, number = {3}, publisher = {American Psychological Association}, address = {Washington}, issn = {0096-3445}, doi = {10.1037/xge0000367}, pages = {377 -- 397}, year = {2018}, abstract = {Most psychological models are intended to describe processes that operate within each individual. In many research areas, however, models are tested by looking at results averaged across many individuals, despite the fact that such averaged results may give a misleading picture of what is true for each one. We consider this conundrum with respect to the interpretation of on-average null effects. Specifically, even though an experimental manipulation might have no effect on average across individuals, it might still have demonstrable effects-albeit in opposite directions-for many or all of the individuals tested. We discuss several examples of research questions for which it would be theoretically crucial to determine whether manipulations really have no effect at the individual level, and we present a method of testing for individual-level effects.}, language = {en} } @article{SchachnerVandeVijverNoack2018, author = {Schachner, Maja Katharina and Van de Vijver, Fons J. R. and Noack, Peter}, title = {Acculturation and School Adjustment of Early-Adolescent Immigrant Boys and Girls in Germany}, series = {The Journal of Early Adolescence}, volume = {38}, journal = {The Journal of Early Adolescence}, number = {3}, publisher = {Sage Publ.}, address = {Thousand Oaks}, issn = {0272-4316}, doi = {10.1177/0272431616670991}, pages = {352 -- 384}, year = {2018}, abstract = {Navigating between cultures in addition to developmental changes and challenges in early adolescence can be difficult. We investigated school, family, and ethnic group as conditions for acculturation and school adjustment among early-adolescent boys and girls. Analyses were based on 860 mostly second- and third-generation immigrant students from 71 countries (50\% male; M-age = 11.59 years), attending German secondary schools. Perceived support for inclusion and integration in school and family were associated with a stronger orientation toward both cultures (integration) and better adjustment (e.g., higher school marks, more well-being). Perceived cultural distance and ethnic discrimination were associated with a stronger ethnic and weaker mainstream orientation (separation), and lower adjustment. Boys perceived contextual conditions more negatively, had a weaker mainstream orientation, and showed more behavioral problems but did not differ from girls in the associations between contextual conditions and acculturation and adjustment. Implications for research, policy, and practice are discussed.}, language = {en} } @article{KueblerFriedrichGoldetal.2018, author = {K{\"u}bler, Simon and Friedrich, Anke M. and Gold, Ryan D. and Strecker, Manfred}, title = {Historical coseismic surface deformation of fluvial gravel deposits, Schafberg fault, Lower Rhine Graben, Germany}, series = {International journal of earth sciences}, volume = {107}, journal = {International journal of earth sciences}, number = {2}, publisher = {Springer}, address = {New York}, issn = {1437-3254}, doi = {10.1007/s00531-017-1510-9}, pages = {571 -- 585}, year = {2018}, abstract = {Intraplate earthquakes pose a significant seismic hazard in densely populated rift systems like the Lower Rhine Graben in Central Europe. While the locations of most faults in this region are well known, constraints on their seismogenic potential and earthquake recurrence are limited. In particular, the Holocene deformation history of active faults remains enigmatic. In an exposure excavated across the Schafberg fault in the southwestern Lower Rhine Graben, south of Untermaubach, in the epicentral region of the 1756 Duren earthquake (M (L) 6.2), we mapped a complex deformation zone in Holocene fluvial sediments. We document evidence for at least one paleoearthquake that resulted in vertical surface displacement of 1.2 +/- 0.2 m. The most recent earthquake is constrained to have occurred after 815 AD, and we have modeled three possible earthquake scenarios constraining the timing of the latest event. Coseismic deformation is characterized by vertical offset of sedimentary contacts distributed over a 10-m-wide central damage zone. Faults were identified where they fracture and offset pebbles in the vertically displaced gravel layers and fracture orientation is consistent with the orientation of the Schafberg fault. This study provides the first constraint on the most recent surface-rupturing earthquake on the Schafberg fault. We cannot rule out that this fault acted as the source of the 1756 Duren earthquake. Our study emphasizes the importance of, and the need for, paleoseismic studies in this and other intracontinental regions, in particular on faults with subtle geomorphic expression that would not typically be recognized as being potentially seismically active. Our study documents textural features in unconsolidated sediment that formed in response to coseismic rupturing of the underlying bedrock fault. We suggest that these features, e.g., abundant oriented transgranular fractures in their context, should be added to the list of criteria used to identify a fault as potentially active. Such information would result in an increase of the number of potentially active faults that contribute to seismic hazards of intracontinental regions.}, language = {en} } @article{FienerWilkenAldanaJagueetal.2018, author = {Fiener, P. and Wilken, F. and Aldana-Jague, E. and Deumlich, D. and Gomez, J. A. and Guzman, G. and Hardy, R. A. and Quinton, J. N. and Sommer, M. and Van Oost, K. and Wexler, R.}, title = {Uncertainties in assessing tillage erosion}, series = {Geomorphology : an international journal on pure and applied geomorphology}, volume = {304}, journal = {Geomorphology : an international journal on pure and applied geomorphology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0169-555X}, doi = {10.1016/j.geomorph.2017.12.031}, pages = {214 -- 225}, year = {2018}, abstract = {Tillage erosion on arable land is a very important process leading to a net downslope movement of soil and soil constitutes. Tillage erosion rates are commonly in the same order of magnitude as water erosion rates and can be even higher, especially under highly mechanized agricultural soil management. Despite its prevalence and magnitude, tillage erosion is still understudied compared to water erosion. The goal of this study was to bring together experts using different techniques to determine tillage erosion and use the different results to discuss and quantify uncertainties associated with tillage erosion measurements. The study was performed in northeastern Germany on a 10 m by 50 m plot with a mean slope of 8\%. Tillage erosion was determined after two sequences of seven tillage operations. Two different micro-tracers (magnetic iron oxide mixed with soil and fluorescent sand) and one macro-tracer (passive radio-frequency identification transponders (RFIDs), size: 4 x 22 mm) were used to directly determine soil fluxes. Moreover, tillage induced changes in topography were measured for the entire plot with two different terrestrial laser scanners and an unmanned aerial system for structure from motion topography analysis. Based on these elevation differences, corresponding soil fluxes were calculated. The mean translocation distance of all techniques was 0.57 m per tillage pass, with a relatively wide range of mean soil translocation distances ranging from 039 to 0.72 m per pass. A benchmark technique could not be identified as all used techniques have individual error sources, which could not be quantified. However, the translocation distances of the macro-tracers used were consistently smaller than the translocation distances of the micro-tracers (mean difference = -26 +/- 12\%), which questions the widely used assumption of non-selective soil transport via tillage operations. This study points out that tillage erosion measurements, carried out under almost optimal conditions, are subject to major uncertainties that are far from negligible. (C) 2018 Elsevier B.V. All rights reserved.}, language = {en} } @article{PilusoVukicevieNoecheletal.2018, author = {Piluso, Susanna and Vukicevie, Radovan and N{\"o}chel, Ulrich and Braune, Steffen and Lendlein, Andreas and Neffe, Axel T.}, title = {Sequential alkyne-azide cycloadditions for functionalized gelatin hydrogel formation}, series = {European polymer journal}, volume = {100}, journal = {European polymer journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0014-3057}, doi = {10.1016/j.eurpolymj.2018.01.017}, pages = {77 -- 85}, year = {2018}, abstract = {While click chemistry reactions for biopolymer network formation are attractive as the defined reactions may allow good control of the network formation and enable subsequent functionalization, tailoring of gelatin network properties over a wide range of mechanical properties has yet to be shown. Here, it is demonstrated that copper-catalyzed alkyne-azide cycloaddition of alkyne functionalized gelatin with diazides gave hydrogel networks with properties tailorable by the ratio of diazide to gelatin and diazide rigidity. 4,4′-diazido-2,2′-stilbenedisulfonic acid, which has been used as rigid crosslinker, yielded hydrogels with Young's moduli E of 50-390 kPa and swelling degrees Q of 150-250 vol.\%, while the more flexible 1,8-diazidooctane resulted in hydrogels with E = 125-280 kPa and Q = 225-470 vol.\%. Storage moduli could be varied by two orders of magnitude (G′ = 100-20,000 Pa). An indirect cytotoxicity test did not show cytotoxic properties. Even when employing 1:1 ratios of alkyne and azide moieties, the hydrogels were shown to contain both, unreacted alkyne groups on the gelatin backbone as well as dangling chains carrying azide groups as shown by reaction with functionalized fluorescein. The free groups, which can be tailored by the employed ratio of the reactants, are accessible for covalent attachment of drugs, as was demonstrated by functionalization with dexamethasone. The sequential network formation and functionalization with click chemistry allows access to multifunctional materials relevant for medical applications.}, language = {en} } @article{LischkeJungeHammetal.2018, author = {Lischke, Alexander and Junge, Martin and Hamm, Alfons O. and Weymar, Mathias}, title = {Enhanced processing of untrustworthiness in natural faces with neutral expressions}, series = {Emotion : a new journal from the American Psychological Association}, volume = {18}, journal = {Emotion : a new journal from the American Psychological Association}, number = {2}, publisher = {American Psychological Association}, address = {Washington}, issn = {1528-3542}, doi = {10.1037/emo0000318}, pages = {181 -- 189}, year = {2018}, abstract = {During social interactions, individuals rapidly and automatically judge others' trustworthiness on the basis of subtle facial cues. To investigate the behavioral and neural correlates of these judgments, we conducted 2 studies: 1 study for the construction and evaluation of a set of natural faces differing in trustworthiness (Study 1: n = 30) and another study for the investigation of event-related potentials (ERPs) in response to this set of natural faces (Study 2: n = 30). Participants of both studies provided highly reliable and nearly identical trustworthiness ratings for the selected faces, supporting the notion that the discrimination of trustworthy and untrustworthy faces depends on distinct facial cues. These cues appear to be processed in an automatic and bottom-up-driven fashion because the free viewing of these faces was sufficient to elicit trustworthiness-related differences in late positive potentials (LPPs) as indicated by larger amplitudes to untrustworthy as compared with trustworthy faces. Taken together, these findings suggest that natural faces contain distinct cues that are automatically and rapidly processed to facilitate the discrimination of untrustworthy and trustworthy faces across various contexts, presumably by enhancing the elaborative processing of untrustworthy as compared with trustworthy faces. (}, language = {en} } @article{BougeoisDupontNivetdeRafelisetal.2018, author = {Bougeois, Laurie and Dupont-Nivet, Guillaume and de Rafelis, Marc and Tindall, Julia C. and Proust, Jean-Noel and Reichart, Gert-Jan and de Nooijer, Lennart J. and Guo, Zhaojie and Ormukov, Cholponbelk}, title = {Asian monsoons and aridification response to Paleogene sea retreat and Neogene westerly shielding indicated by seasonality in Paratethys oysters}, series = {Earth and planetary science letters}, volume = {485}, journal = {Earth and planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2017.12.036}, pages = {99 -- 110}, year = {2018}, abstract = {Asian climate patterns, characterised by highly seasonal monsoons and continentality, are thought to originate in the Eocene epoch (56 to 34 million years ago - Ma) in response to global climate, Tibetan Plateau uplift and the disappearance of the giant Proto-Paratethys sea formerly extending over Eurasia. The influence of this sea on Asian climate has hitherto not been constrained by proxy records despite being recognised as a major driver by climate models. We report here strongly seasonal records preserved in annual lamina of Eocene oysters from the Proto-Paratethys with sedimentological and numerical data showing that monsoons were not dampened by the sea and that aridification was modulated by westerly moisture sourced from the sea. Hot and arid summers despite the presence of the sea suggest a strong anticyclonic zone at Central Asian latitudes and an orographic effect from the emerging Tibetan Plateau. Westerly moisture precipitating during cold and wetter winters appear to have decreased in two steps. First in response to the late Eocene (34-37 Ma) sea retreat; second by the orogeny of the Tian Shan and Pamir ranges shielding the westerlies after 25 Ma. Paleogene sea retreat and Neogene westerly shielding thus provide two successive mechanisms forcing coeval Asian desertification and biotic crises.}, language = {en} } @article{MazzaEccardZaccaronietal.2018, author = {Mazza, Valeria and Eccard, Jana and Zaccaroni, Marco and Jacob, Jens and Dammhahn, Melanie}, title = {The fast and the flexible}, series = {Animal behaviour}, volume = {137}, journal = {Animal behaviour}, publisher = {Elsevier}, address = {London}, issn = {0003-3472}, doi = {10.1016/j.anbehav.2018.01.011}, pages = {119 -- 132}, year = {2018}, language = {en} } @article{UolaLeverGuehneetal.2018, author = {Uola, Roope and Lever, Fabiano and G{\"u}hne, Otfried and Pellonpaa, Juha-Pekka}, title = {Unified picture for spatial, temporal, and channel steering}, series = {Physical review : A, Atomic, molecular, and optical physics}, volume = {97}, journal = {Physical review : A, Atomic, molecular, and optical physics}, number = {3}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9926}, doi = {10.1103/PhysRevA.97.032301}, pages = {6}, year = {2018}, abstract = {Quantum steering describes how local actions on a quantum system can affect another, spacelike separated, quantum state. Lately, quantum steering has been formulated also for timelike scenarios and for quantum channels. We approach all the three scenarios as one using tools from Stinespring dilations of quantum channels. By applying our technique we link all three steering problems one-to-one with the incompatibility of quantum measurements, a result formerly known only for spatial steering. We exploit this connection by showing how measurement uncertainty relations can be used as tight steering inequalities for all three scenarios. Moreover, we show that certain notions of temporal and spatial steering are fully equivalent and prove a hierarchy between temporal steering and macrorealistic hidden variable models.}, language = {en} } @article{AbdallaCollaborationAbramowskietal.2018, author = {Abdalla, Hassan E. and Collaboration, H. E. S. S. and Abramowski, A. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Armand, C. and Arrieta, M. and Backes, M. and Balzer, A. and Barnard, M. and Becherini, Y. and Tjus, J. Becker and Berge, D. and Bernhard, S. and Bernloehr, K. and Blackwell, R. and Bottcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bordas, Pol and Bregeon, J. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chaves, R. C. G. and Chen, A. and Chevalier, J. and Colafrancesco, S. and Condon, B. and Conrad, J. and Davids, I. D. and Decock, J. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Donath, A. and Dyks, J. and Edwards, T. and Egberts, Kathrin and Emery, G. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, S. and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Funk, S. and Fuessling, M. and Gabici, S. and Gallant, Y. A. and Garrigoux, T. and Gate, F. and Giavitto, G. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hawkes, J. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horns, D. and Ivascenko, A. and Iwasaki, H. and Jacholkowska, A. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jingo, M. and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Kerszberg, D. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Klochkov, D. and Kluzniak, W. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, J. and Lefaucheur, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, T. and Lorentz, M. and Liu, R. and Lopez-Coto, R. and Lypova, I. and Malyshev, D. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, M. and Meintjes, P. J. and Meyer, M. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Mora, K. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Pekeur, N. W. and Pelletier, G. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Renaud, M. and de los Reyes, R. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Saito, S. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Shiningayamwe, K. and Simoni, R. and Sol, H. and Spanier, F. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Sushch, I. and Takahashi, T. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, R. and Zaborov, D. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zorn, J. and Zywucka, N.}, title = {Detection of variable VHE gamma-ray emission from the extra-galactic gamma-ray binary LMC P3}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {610}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201732426}, pages = {5}, year = {2018}, abstract = {Context. Recently, the high-energy (HE, 0.1-100 GeV) gamma-ray emission from the object LMC P3 in the Large Magellanic Cloud (LMC) has been discovered to be modulated with a 10.3-day period, making it the first extra-galactic gamma-ray binary. Aims. This work aims at the detection of very-high-energy (VHE, >100 GeV) gamma-ray emission and the search for modulation of the VHE signal with the orbital period of the binary system. Methods. LMC P3 has been observed with the High Energy Stereoscopic System (H.E.S.S.); the acceptance-corrected exposure time is 100 h. The data set has been folded with the known orbital period of the system in order to test for variability of the emission. Results. VHE gamma-ray emission is detected with a statistical significance of 6.4 sigma. The data clearly show variability which is phase-locked to the orbital period of the system. Periodicity cannot be deduced from the H.E.S.S. data set alone. The orbit-averaged luminosity in the 1-10 TeV energy range is (1.4 +/- 0.2) x 10(35) erg s(-1). A luminosity of (5 +/- 1) x 10(35) erg s(-1) is reached during 20\% of the orbit. HE and VHE gamma-ray emissions are anti-correlated. LMC P3 is the most luminous gamma-ray binary known so far.}, language = {en} } @article{StoesselSchultedosSantosetal.2018, author = {Stoessel, Daniel and Schulte, Claudia and dos Santos, Marcia C. Teixeira and Scheller, Dieter and Rebollo-Mesa, Irene and Deuschle, Christian and Walther, Dirk and Schauer, Nicolas and Berg, Daniela and da Costa, Andre Nogueira and Maetzler, Walter}, title = {Promising Metabolite Profiles in the Plasma and CSF of Early Clinical}, series = {Frontiers in Aging Neuroscience}, volume = {10}, journal = {Frontiers in Aging Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1663-4365}, doi = {10.3389/fnagi.2018.00051}, pages = {14}, year = {2018}, abstract = {Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD}, language = {en} } @article{FitzsimmonsSprafkeZielhoferetal.2018, author = {Fitzsimmons, Kathryn E. and Sprafke, Tobias and Zielhofer, Christoph and G{\"u}nter, Christina and Deom, Jean-Marc and Sala, Renato and Iovita, Radu}, title = {Loess accumulation in the Tian Shan piedmont}, series = {Quaternary international : the journal of the International Union for Quaternary Research}, volume = {469}, journal = {Quaternary international : the journal of the International Union for Quaternary Research}, publisher = {Elsevier}, address = {Oxford}, issn = {1040-6182}, doi = {10.1016/j.quaint.2016.07.041}, pages = {30 -- 43}, year = {2018}, abstract = {Whilst correlations have been made between the loess of Europe and China, deposits in Central Asia have remained largely overlooked by scientific investigation. The nature of the relationship between loess accumulation and palaeoclimate at the core of the Eurasian loess belt is particularly poorly understood. Here we reconstruct palaeoenvironmental change in Central Asia over the last 40 ky based on data from the Remizovka loess profile, in the northern foothills of the Tian Shan in southern Kazakhstan. Our interpretations are based on synthesis of chronostratigraphic, colour and magnetic susceptibility data, supported by chronostratigraphies from two additional sites nearby, Maibulak and Valikhanova. All three sites record substantially increased loess accumulation during late MIS 3 into the global last glacial maximum (gLGM). At Remizovka, increased loess flux occurred in two pulses at c. 38-25 ka and 22-18 ka, with the intervening period involving incipient pedogenesis. At Maibulak, two loess pulses at c. 40-30 ka and c. 28-22 ka are separated by a weakly developed paleosol which may date to the same time as pedogenesis at Remizovka. There is additional possible periglacial influence at Maibulak from c. 40-33.5 ka. At Valikhanova, there is some age overlap between paleosol and loess samples, but overall loess accumulation appears to have increased at c. 42-35 ka, c. 30 ka and the gLGM, with pedogenesis occurring >40 ka and c. 32 ka. At all three sites, Holocene loess accumulation is minimal; this period is characterised by pedogenesis. The chronostratigraphic variability between our sites highlights a need to interrogate climate-driven models for loess formation in piedmont environments. We interpret our data in the context of regional palaeoenvironmental archives to indicate that loess accumulation increased coeval with MIS 3 glacial advance in the Tian Shan, which was facilitated by northward expansion of the Asian monsoon and associated increase in precipitation. We hypothesise that increased ice volume impeded teleconnections with the temperate zone westerlies to the north; these were compressed against the piedmont resulting in increased wind strength and facilitating increased loess flux. Peak loess accumulation during the gLGM occurred under colder, drier climatic conditions, with reduced but sustained glacial ice volume and persistent influence of the westerlies in the arid Central Asian piedmont loess belt. In the absence of more widespread, reliably dated palaeoenvironmental records from the region, our data become of critical importance for understanding past environmental conditions in Central Asia, relative to elsewhere in Eurasia and globally.}, language = {en} } @article{PitzenAskarzadaGraefetal.2018, author = {Pitzen, Valentin and Askarzada, Sophie and Gr{\"a}f, Ralph and Meyer, Irene}, title = {CDK5RAP2 Is an Essential Scaffolding Protein of the Corona of the Dictyostelium Centrosome}, series = {Cells}, volume = {7}, journal = {Cells}, number = {4}, publisher = {MDPI}, address = {Basel}, issn = {2073-4409}, doi = {10.3390/cells7040032}, pages = {17}, year = {2018}, abstract = {Dictyostelium centrosomes consist of a nucleus-associated cylindrical, three-layered core structure surrounded by a corona consisting of microtubule-nucleation complexes embedded in a scaffold of large coiled-coil proteins. One of them is the conserved CDK5RAP2 protein. Here we focus on the role of Dictyostelium CDK5RAP2 for maintenance of centrosome integrity, its interaction partners and its dynamic behavior during interphase and mitosis. GFP-CDK5RAP2 is present at the centrosome during the entire cell cycle except from a short period during prophase, correlating with the normal dissociation of the corona at this stage. RNAi depletion of CDK5RAP2 results in complete disorganization of centrosomes and microtubules suggesting that CDK5RAP2 is required for organization of the corona and its association to the core structure. This is in line with the observation that overexpressed GFP-CDK5RAP2 elicited supernumerary cytosolic MTOCs. The phenotype of CDK5RAP2 depletion was very reminiscent of that observed upon depletion of CP148, another scaffolding protein of the corona. BioID interaction assays revealed an interaction of CDK5RAP2 not only with the corona markers CP148, gamma-tubulin, and CP248, but also with the core components Cep192, CP75, and CP91. Furthermore, protein localization studies in both depletion strains revealed that CP148 and CDK5RAP2 cooperate in corona organization.}, language = {en} } @article{ArminChenJinetal.2018, author = {Armin, Ardalan and Chen, Zhiming and Jin, Yaocheng and Zhang, Kai and Huang, Fei and Shoaee, Safa}, title = {A Shockley-Type polymer}, series = {Advanced energy materials}, volume = {8}, journal = {Advanced energy materials}, number = {7}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1614-6832}, doi = {10.1002/aenm.201701450}, pages = {9}, year = {2018}, abstract = {Charge extraction rate in solar cells made of blends of electron donating/accepting organic semiconductors is typically slow due to their low charge carrier mobility. This sets a limit on the active layer thickness and has hindered the industrialization of organic solar cells (OSCs). Herein, charge transport and recombination properties of an efficient polymer (NT812):fullerene blend are investigated. This system delivers power conversion efficiency of >9\% even when the junction thickness is as large as 800 nm. Experimental results indicate that this material system exhibits exceptionally low bimolecular recombination constant, 800 times smaller than the diffusion-controlled electron and hole encounter rate. Comparing theoretical results based on a recently introduced modified Shockley model for fill factor, and experiments, clarifies that charge collection is nearly ideal in these solar cells even when the thickness is several hundreds of nanometer. This is the first realization of high-efficiency Shockley-type organic solar cells with junction thicknesses suitable for scaling up.}, language = {en} } @article{GudipudiLuedekeRybskietal.2018, author = {Gudipudi, Ramana Venkata and L{\"u}deke, Matthias K. B. and Rybski, Diego and Kropp, J{\"u}rgen}, title = {Benchmarking urban eco-efficiency and urbanites' perception}, series = {Cities}, volume = {74}, journal = {Cities}, publisher = {Elsevier}, address = {Oxford}, issn = {0264-2751}, doi = {10.1016/j.cities.2017.11.009}, pages = {109 -- 118}, year = {2018}, abstract = {Urbanization as an inexorable global trend stresses the need to identify cities which are eco-efficient. These cities enable socioeconomic development with lower environmental burden, both being multidimensional concepts. Based on this approach, we benchmark 88 European cities using (i) an advanced version of regression residual ranking and (ii) Data Envelopment Analysis (DEA). Our results show that Stockholm, Munich and Oslo perform well irrespective of the benchmarking method. Furthermore, our results indicate that larger European cities are eco-efficient given the socioeconomic benefits they offer compared to smaller cities. In addition, we analyze correlations between a subjective public perception ranking and our objective eco-efficiency rankings for a subset of 45 cities. This exercise revealed three insights: (1) public perception about quality of life in a city is not merely confined to the socioeconomic well-being but rather to its combination with a lower environmental burden; (2) public perception correlates well with both formal ranking outcomes, corroborating the choice of variables; and (3) the advanced regression residual method appears to be more adequate to fit the urbanites' perception ranking (correlation coefficient about 0.6). This can be interpreted as an indication that urbanites' perception reflects the typical eco-efficiency performance and is less influenced by exceptionally performing cities (in the latter case, DEA should have better correlation coefficient). This study highlights that the socioeconomic growth in cities should not be environmentally detrimental as this might lead to significant discontent regarding perceived quality of urban life.}, language = {en} } @article{HenkelKlimchitskayaMostepanenko2018, author = {Henkel, Carsten and Klimchitskaya, G. L. and Mostepanenko, V. M.}, title = {Influence of the chemical potential on the Casimir-Polder interaction between an atom and gapped graphene or a graphene-coated substrate}, series = {Physical review : A, Atomic, molecular, and optical physics}, volume = {97}, journal = {Physical review : A, Atomic, molecular, and optical physics}, number = {3}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9926}, doi = {10.1103/PhysRevA.97.032504}, pages = {12}, year = {2018}, abstract = {We present a formalism based on first principles of quantum electrodynamics at nonzero temperature which permits us to calculate the Casimir-Polder interaction between an atom and a graphene sheet with arbitrary mass gap and chemical potential, including graphene-coated substrates. The free energy and force of the Casimir-Polder interaction are expressed via the polarization tensor of graphene in (2 + 1)-dimensional space-time in the framework of the Dirac model. The obtained expressions are used to investigate the influence of the chemical potential of graphene on the Casimir-Polder interaction. Computations are performed for an atom of metastable helium interacting with either a freestanding graphene sheet or a graphene-coated substrate made of amorphous silica. It is shown that the impacts of the nonzero chemical potential and the mass gap on the Casimir-Polder interaction are in opposite directions, by increasing and decreasing the magnitudes of the free energy and force, respectively. It turns out, however, that the temperature-dependent part of the Casimir-Polder interaction is decreased by a nonzero chemical potential, whereas the mass gap increases it compared to the case of undoped, gapless graphene. The physical explanation for these effects is provided. Numerical computations of the Casimir-Polder interaction are performed at various temperatures and atom-graphene separations.}, language = {en} } @article{WeberPutaLesinskietal.2018, author = {Weber, Stephanie and Puta, Christian and Lesinski, Melanie and Gabriel, Brunhild and Steidten, Thomas and B{\"a}r, Karl-J{\"u}rgen and Herbsleb, Marco and Granacher, Urs and Gabriel, Holger H. W.}, title = {Symptoms of anxiety and depression in young athletes using the hospital anxiety and depression scale}, series = {Frontiers in physiology}, volume = {9}, journal = {Frontiers in physiology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-042X}, doi = {10.3389/fphys.2018.00182}, pages = {12}, year = {2018}, abstract = {Elite young athletes have to cope with multiple psychological demands such as training volume, mental and physical fatigue, spatial separation of family and friends or time management problems may lead to reduced mental and physical recovery. While normative data regarding symptoms of anxiety and depression for the general population is available (Hinz and Brahler, 2011), hardly any information exists for adolescents in general and young athletes in particular. Therefore, the aim of this study was to assess overall symptoms of anxiety and depression in young athletes as well as possible sex differences. The survey was carried out within the scope of the study "Resistance Training in Young Athletes" (KINGS-Study). Between August 2015 and September 2016, 326 young athletes aged (mean +/- SD) 14.3 +/- 1.6 years completed the Hospital Anxiety and Depression Scale (HAD Scale). Regarding the analysis of age on the anxiety and depression subscales, age groups were classified as follows: late childhood (12-14 years) and late adolescence (15-18 years). The participating young athletes were recruited from Olympic weight lifting, handball, judo, track and field athletics, boxing, soccer, gymnastics, ice speed skating, volleyball, and rowing. Anxiety and depression scores were (mean +/- SD) 4.3 +/- 3.0 and 2.8 +/- 2.9, respectively. In the subscale anxiety, 22 cases (6.7\%) showed subclinical scores and 11 cases (3.4\%) showed clinical relevant score values. When analyzing the depression subscale, 31 cases (9.5\%) showed subclinical score values and 12 cases (3.7\%) showed clinically important values. No significant differences were found between male and female athletes (p >= 0.05). No statistically significant differences in the HADS scores were found between male athletes of late childhood and late adolescents (p >= 0.05). To the best of our knowledge, this is the first report describing questionnaire based indicators of symptoms of anxiety and depression in young athletes. Our data implies the need for sports medical as well as sports psychiatric support for young athletes. In addition, our results demonstrated that the chronological classification concerning age did not influence HAD Scale outcomes. Future research should focus on sports medical and sports psychiatric interventional approaches with the goal to prevent anxiety and depression as well as teaching coping strategies to young athletes.}, language = {en} } @article{AravopoulouKyriakosMiasnikovaetal.2018, author = {Aravopoulou, Dionysia and Kyriakos, Konstantinos and Miasnikova, Anna and Laschewsky, Andre and Papadakis, Christine M. and Kyritsis, Apostolos}, title = {Comparative Investigation of the Thermoresponsive Behavior of Two Diblock Copolymers Comprising PNIPAM and PMDEGA Blocks}, series = {The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces \& biophysical chemistry}, volume = {122}, journal = {The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces \& biophysical chemistry}, number = {9}, publisher = {American Chemical Society}, address = {Washington}, issn = {1520-6106}, doi = {10.1021/acs.jpcb.7b09647}, pages = {2655 -- 2668}, year = {2018}, abstract = {The thermoresponsive behavior of two diblock copolymers PS-b-PNIPAM and PS-b-PMDEGA, which both comprise a hydrophobic polystyrene (PS) block but different thermoresponsive blocks, also differing in length, poly(N-isopropylacrylamide) (PNIPAM) and poly(methoxy diethylene glycol acrylate) (PMDEGA), respectively, was comparatively investigated in a wide temperature range. Concentrated aqueous solutions containing 25 wt \% polymer were studied by small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), and broadband dielectric spectroscopy (BDS). DSC measurements show that, during the demixing phase transition, the hydration number per oligo(ethylene glycol) side chain in the PS-b-PMDEGA solution decreases rather gradually, even up to 20 °C above the onset of the transition, i.e., the cloud point (CP). In contrast, the PS-b-PNIPAM solution exhibits an abrupt, stepwise dehydration behavior at its CP, indicated by the sharp, narrow endothermic peak. BDS measurements suggest that the organization of the expelled water during the phase transition and the subsequent evolution of the micellar aggregates are different for the two copolymers. In the PS-b-PMDEGA solution, the long-range charge transport process changes significantly at its CP and strong interfacial polarization processes appear, probably due to charge accumulation at the interfaces between the micellar aggregates and the aqueous medium. On the contrary, in the PS-b-PNIPAM solution, the phase transition has only a marginal effect on the long-range conduction process and is accompanied by a reduction in the high-frequency (1 MHz) dielectric permittivity, ε′. The latter effect is attributed to the reduced polarization strength of local chain modes due to an enhancement of intra- and interchain hydrogen bonds (HBs) in the polymer-rich phase during the water detaching process. Surprisingly, our BDS measurements indicate that prior to both the demixing and remixing processes the local chain mobility increases temporally. Our dielectric studies suggest that for PS-b-PNIPAM the water detaching process initiates a few degrees below CP and that the local chain mobility and intra- and/or interchain HBs of the PNIPAM blocks may control its thermoresponsive behavior. Dielectric "jump" experiments show that the kinetics of micellar aggregation in the PS-b-PMDEGA solution is slower than that in the PS-b-PNIPAM solution and is independent of the target temperature within the two-phase region. From the experimental point of view, it is shown that the dielectric susceptibility, especially, the dielectric permittivity, ε′, is a well-suited probe for monitoring both the reversible changes in the molecular dipolar bond polarizability and the long-range interfacial polarization at the phase transition.}, language = {en} } @article{SchroenZachariasWomacketal.2018, author = {Schr{\"o}n, Martin and Zacharias, Steffen and Womack, Gary and K{\"o}hli, Markus and Desilets, Darin and Oswald, Sascha and Bumberger, Jan and Mollenhauer, Hannes and K{\"o}gler, Simon and Remmler, Paul and Kasner, Mandy and Denk, Astrid and Dietrich, Peter}, title = {Intercomparison of cosmic-ray neutron sensors and water balance monitoring in an urban environment}, series = {Geoscientific instrumentation, methods and data systems}, volume = {7}, journal = {Geoscientific instrumentation, methods and data systems}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2193-0856}, doi = {10.5194/gi-7-83-2018}, pages = {83 -- 99}, year = {2018}, abstract = {Sensor-to-sensor variability is a source of error common to all geoscientific instruments that needs to be assessed before comparative and applied research can be performed with multiple sensors. Consistency among sensor systems is especially critical when subtle features of the surrounding terrain are to be identified. Cosmic-ray neutron sensors (CRNSs) are a recent technology used to monitor hectometre-scale environmental water storages, for which a rigorous comparison study of numerous co-located sensors has not yet been performed. In this work, nine stationary CRNS probes of type "CRS1000" were installed in relative proximity on a grass patch surrounded by trees, buildings, and sealed areas. While the dynamics of the neutron count rates were found to be similar, offsets of a few percent from the absolute average neutron count rates were found. Technical adjustments of the individual detection parameters brought all instruments into good agreement. Furthermore, we found a critical integration time of 6 h above which all sensors showed consistent dynamics in the data and their RMSE fell below 1\% of gravimetric water content. The residual differences between the nine signals indicated local effects of the complex urban terrain on the scale of several metres. Mobile CRNS measurements and spatial simulations with the URANOS neutron transport code in the surrounding area (25 ha) have revealed substantial sub-footprint heterogeneity to which CRNS detectors are sensitive despite their large averaging volume. The sealed and constantly dry structures in the footprint furthermore damped the dynamics of the CRNS-derived soil moisture. We developed strategies to correct for the sealed-area effect based on theoretical insights about the spatial sensitivity of the sensor. This procedure not only led to reliable soil moisture estimation during dry-out periods, it further revealed a strong signal of intercepted water that emerged over the sealed surfaces during rain events. The presented arrangement offered a unique opportunity to demonstrate the CRNS performance in complex terrain, and the results indicated great potential for further applications in urban climate research.}, language = {en} } @article{RamageIrrgangMorgensternetal.2018, author = {Ramage, Justine Lucille and Irrgang, Anna Maria and Morgenstern, Anne and Lantuit, Hugues}, title = {Increasing coastal slump activity impacts the release of sediment and organic carbon into the Arctic Ocean}, series = {Biogeosciences}, volume = {15}, journal = {Biogeosciences}, number = {5}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-15-1483-2018}, pages = {1483 -- 1495}, year = {2018}, abstract = {Retrogressive thaw slumps (RTSs) are among the most active thermokarst landforms in the Arctic and deliver a large amount of material to the Arctic Ocean. However, their contribution to the organic carbon (OC) budget is unknown. We provide the first estimate of the contribution of RTSs to the nearshore OC budget of the Yukon Coast, Canada, and describe the evolution of coastal RTSs between 1952 and 2011 in this area. We (1) describe the evolution of RTSs between 1952 and 2011; (2) calculate the volume of eroded material and stocks of OC mobilized through slumping, including soil organic carbon (SOC) and dissolved organic carbon (DOC); and (3) estimate the OC fluxes mobilized through slumping between 1972 and 2011. We identified RTSs using high- resolution satellite imagery from 2011 and geocoded aerial photographs from 1952 and 1972. To estimate the volume of eroded material, we applied spline interpolation on an airborne lidar dataset acquired in July 2013. We inferred the stocks of mobilized SOC and DOC from existing related literature. Our results show a 73\% increase in the number of RTSs and 14\% areal expansion between 1952 and 2011. In the study area, RTSs displaced at least 16.6 x 10(6) m(3) of material, 53\% of which was ice, and mobilized 145.9 x 10(6) kg of OC. Between 1972 and 2011, 49 RTSs displaced 8.6 x 10(3) m(3) yr(-1) of material, adding 0.6\% to the OC flux released by coastal retreat along the Yukon Coast. Our results show that the contribution of RTSs to the nearshore OC budget is non-negligible and should be included when estimating the quantity of OC released from the Arctic coast to the ocean.}, language = {en} } @article{SallenHirschmannHerrmann2018, author = {Sallen, Jeffrey and Hirschmann, Florian and Herrmann, Christian}, title = {Evaluation and Adaption of the Trier Inventory for Chronic Stress (TICS) for Assessment in Competitive Sports}, series = {Frontiers in psychology}, volume = {9}, journal = {Frontiers in psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2018.00308}, pages = {12}, year = {2018}, abstract = {The demands of a career in competitive sports can lead to chronic stress perception among athletes if there is a non-conformity of requirements and available coping resources. The Trier Inventory for Chronic Stress (TICS) (Schulz et al., 2004) is said to be thoroughly validated. Nevertheless, it has not yet been subjected to a confirmatory factor analysis. The present study aims (1) to evaluate the factorial validity of the TICS within the context of competitive sports and (2) to adapt a short version (TICS-36). The total sample consisted of 564 athletes (age in years: M = 19.1, SD = 3.70). The factor structure of the original TICS did not adequately fit the present data, whereas the short version presented a satisfactory fit. The results indicate that the TICS-36 is an economical instrument for gathering interpretable information about chronic stress. For assessment in competitive sports with TICS-36, we generated overall and gender-specific norm values.}, language = {en} } @article{PalkopoulouLipsonMallicketal.2018, author = {Palkopoulou, Eleftheria and Lipson, Mark and Mallick, Swapan and Nielsen, Svend and Rohland, Nadin and Baleka, Sina Isabelle and Karpinski, Emil and Ivancevici, Atma M. and Thu-Hien To, and Kortschak, Daniel and Raison, Joy M. and Qu, Zhipeng and Chin, Tat-Jun and Alt, Kurt W. and Claesson, Stefan and Dalen, Love and MacPhee, Ross D. E. and Meller, Harald and Rocar, Alfred L. and Ryder, Oliver A. and Heiman, David and Young, Sarah and Breen, Matthew and Williams, Christina and Aken, Bronwen L. and Ruffier, Magali and Karlsson, Elinor and Johnson, Jeremy and Di Palma, Federica and Alfoldi, Jessica and Adelsoni, David L. and Mailund, Thomas and Munch, Kasper and Lindblad-Toh, Kerstin and Hofreiter, Michael and Poinar, Hendrik and Reich, David}, title = {A comprehensive genomic history of extinct and living elephants}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {115}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {11}, publisher = {National Acad. of Sciences}, address = {Washington}, issn = {0027-8424}, doi = {10.1073/pnas.1720554115}, pages = {E2566 -- E2574}, year = {2018}, language = {en} } @article{SchulzeMakuchWagnerKounavesetal.2018, author = {Schulze-Makuch, Dirk and Wagner, Dirk and Kounaves, Samuel P. and Mangelsdorf, Kai and Devine, Kevin G. and de Vera, Jean-Pierre and Schmitt-Kopplin, Philippe and Grossart, Hans-Peter and Parro, Victor and Kaupenjohann, Martin and Galy, Albert and Schneider, Beate and Airo, Alessandro and Froesler, Jan and Davila, Alfonso F. and Arens, Felix L. and Caceres, Luis and Cornejo, Francisco Solis and Carrizo, Daniel and Dartnell, Lewis and DiRuggiero, Jocelyne and Flury, Markus and Ganzert, Lars and Gessner, Mark O. and Grathwohl, Peter and Guan, Lisa and Heinz, Jacob and Hess, Matthias and Keppler, Frank and Maus, Deborah and McKay, Christopher P. and Meckenstock, Rainer U. and Montgomery, Wren and Oberlin, Elizabeth A. and Probst, Alexander J. and Saenz, Johan S. and Sattler, Tobias and Schirmack, Janosch and Sephton, Mark A. and Schloter, Michael and Uhl, Jenny and Valenzuela, Bernardita and Vestergaard, Gisle and Woermer, Lars and Zamorano, Pedro}, title = {Transitory microbial habitat in the hyperarid Atacama Desert}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {115}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {11}, publisher = {National Acad. of Sciences}, address = {Washington}, issn = {0027-8424}, doi = {10.1073/pnas.1714341115}, pages = {2670 -- 2675}, year = {2018}, language = {en} } @article{Sachse2018, author = {Sachse, Manuel}, title = {A planetary dust ring generated by impact-ejection from the Galilean satellites}, series = {Icarus : international journal of solar system studies}, volume = {303}, journal = {Icarus : international journal of solar system studies}, publisher = {Elsevier}, address = {San Diego}, issn = {0019-1035}, doi = {10.1016/j.icarus.2017.10.011}, pages = {166 -- 180}, year = {2018}, abstract = {All outer planets in the Solar System are surrounded by a ring system. Many of these rings are dust rings or they contain at least a high proportion of dust. They are often formed by impacts of micro-meteoroids onto embedded bodies. The ejected material typically consists of micron-sized charged particles, which are susceptible to gravitational and non-gravitational forces. Generally, detailed information on the dynamics and distribution of the dust requires expensive numerical simulations of a large number of particles. Here we develop a relatively simple and fast, semi-analytical model for an impact-generated planetary dust ring governed by the planet's gravity and the relevant perturbation forces for the dynamics of small charged particles. The most important parameter of the model is the dust production rate, which is a linear factor in the calculation of the dust densities. We apply our model to dust ejected from the Galilean satellites using production rates obtained from flybys of the dust sources. The dust densities predicted by our model are in good agreement with numerical simulations and with in situ measurements by the Galileo spacecraft. The lifetimes of large particles are about two orders of magnitude greater than those of small ones, which implies a flattening of the size distribution in circumplanetary space. Information about the distribution of circumplanetary dust is also important for the risk assessment of spacecraft orbits in the respective regions.}, language = {en} } @article{WamburaDietrichLischeid2018, author = {Wambura, Frank Joseph and Dietrich, Ottfried and Lischeid, Gunnar}, title = {Improving a distributed hydrological model using evapotranspiration-related boundary conditions as additional constraints in a data-scarce river basin}, series = {Hydrological processes}, volume = {32}, journal = {Hydrological processes}, number = {6}, publisher = {Wiley}, address = {Hoboken}, issn = {0885-6087}, doi = {10.1002/hyp.11453}, pages = {759 -- 775}, year = {2018}, abstract = {Many hydrological models have been calibrated and validated using hydrographs alone. Because streamflow integrates water fluxes in space, many distributed hydrological models tend to have multiple feasible descriptions of hydrological processes. This equifinality usually leads to substantial prediction uncertainty. In this study, additional constraintsnamely, the spatial patterns of long-term average evapotranspiration (ET), shallow groundwater level, and land cover changewere used to investigate the reduction of equifinality and prediction uncertainty in the Soil and Water Assessment Tool (SWAT) in the Wami River basin in Tanzania. The additional constraints were used in the set-up, parameter emulation and calibration of the SWAT model termed an improved hydrological model (IHM). The IHM was then compared with a classical hydrological model (CHM) that was also developed using the SWAT model but without additional constraints. In the calibration, the CHM used only the hydrograph, but the IHM used the hydrograph and the spatial pattern of long-term average ET as an additional constraint. The IHM produced a single, unique behavioural simulation, whereas the CHM produced many behavioural simulations that resulted in prediction uncertainty. The performance of the IHM with respect to the hydrograph was more consistent than that of the CHM, and the former clearly captured the mean behaviour of ET in the river basin. Therefore, we conclude that additional constraints substantially reduce equifinality and prediction uncertainty in a distributed hydrological model.}, language = {en} } @article{VehKorupRoessneretal.2018, author = {Veh, Georg and Korup, Oliver and Roessner, Sigrid and Walz, Ariane}, title = {Detecting Himalayan glacial lake outburst floods from Landsat time series}, series = {Remote sensing of environment : an interdisciplinary journal}, volume = {207}, journal = {Remote sensing of environment : an interdisciplinary journal}, publisher = {Elsevier}, address = {New York}, issn = {0034-4257}, doi = {10.1016/j.rse.2017.12.025}, pages = {84 -- 97}, year = {2018}, abstract = {Several thousands of moraine-dammed and supraglacial lakes spread over the Hindu Kush Himalayan (HKH) region, and some have grown rapidly in past decades due to glacier retreat. The sudden emptying of these lakes releases large volumes of water and sediment in destructive glacial lake outburst floods (GLOFs), one of the most publicised natural hazards to the rapidly growing Himalayan population. Despite the growing number and size of glacial lakes, the frequency of documented GLOFs is remarkably constant. We explore this possible reporting bias and offer a new processing chain for establishing a more complete Himalayan GLOF inventory. We make use of the full seasonal archive of Landsat images between 1988 and 2016, and track automatically where GLOFs left shrinking water bodies, and tails of sediment at high elevations. We trained a Random Forest classifier to generate fuzzy land cover maps for 2491 images, achieving overall accuracies of 91\%. We developed a likelihood-based change point technique to estimate the timing of GLOFs at the pixel scale. Our method objectively detected ten out of eleven documented GLOFs, and another ten lakes that gave rise to previously unreported GLOFs. We thus nearly doubled the existing GLOF record for a study area covering similar to 10\% of the HKH region. Remaining challenges for automatically detecting GLOFs include image insufficiently accurate co-registration, misclassifications in the land cover maps and image noise from clouds, shadows or ice. Yet our processing chain is robust and has the potential for being applied on the greater HKH and mountain ranges elsewhere, opening the door for objectively expanding the knowledge base on GLOF activity over the past three decades.}, language = {en} } @article{PrahlBoettleCostaetal.2018, author = {Prahl, Boris F. and Boettle, Markus and Costa, Lu{\´i}s F{\´i}l{\´i}pe Carvalho da and Kropp, J{\"u}rgen and Rybski, Diego}, title = {Damage and protection cost curves for coastal floods within the 600 largest European cities}, series = {Scientific Data}, volume = {5}, journal = {Scientific Data}, publisher = {Nature Publ. Group}, address = {London}, issn = {2052-4463}, doi = {10.1038/sdata.2018.34}, pages = {18}, year = {2018}, abstract = {The economic assessment of the impacts of storm surges and sea-level rise in coastal cities requires high-level information on the damage and protection costs associated with varying flood heights. We provide a systematically and consistently calculated dataset of macroscale damage and protection cost curves for the 600 largest European coastal cities opening the perspective for a wide range of applications. Offering the first comprehensive dataset to include the costs of dike protection, we provide the underpinning information to run comparative assessments of costs and benefits of coastal adaptation. Aggregate cost curves for coastal flooding at the city-level are commonly regarded as by-products of impact assessments and are generally not published as a standalone dataset. Hence, our work also aims at initiating a more critical discussion on the availability and derivation of cost curves.}, language = {en} } @article{PrommerMaurervonWebskyetal.2018, author = {Prommer, Hans-Ulrich and Maurer, Johannes and von Websky, Karoline and Freise, Christian and Sommer, Kerstin and Nasser, Hamoud and Samapati, Rudi and Reglin, Bettina and Guimaraes, Pedro and Pries, Axel Radlach and Querfeld, Uwe}, title = {Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis}, series = {Scientific reports}, volume = {8}, journal = {Scientific reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-018-23663-1}, pages = {14}, year = {2018}, abstract = {Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1 alpha, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis.}, language = {en} } @article{OguntundeLischeidAbiodun2018, author = {Oguntunde, Philip G. and Lischeid, Gunnar and Abiodun, Babatunde Joseph}, title = {Impacts of climate variability and change on drought characteristics in the Niger River Basin, West Africa}, series = {Stochastic Environmental Research and Risk Assessment}, volume = {32}, journal = {Stochastic Environmental Research and Risk Assessment}, number = {4}, publisher = {Springer}, address = {New York}, issn = {1436-3240}, doi = {10.1007/s00477-017-1484-y}, pages = {1017 -- 1034}, year = {2018}, abstract = {West Africa has been afflicted by droughts since the declining rains of the 1970s. Therefore, this study examines the characteristics of drought over the Niger River Basin (NRB), investigates the influence of the drought on the river flow, and projects the impacts of future climate change on drought. A combination of observation data and regional climate simulations of past (1986-2005) and future climates (2046-2065 and 2081-2100) were analyzed. The standardized precipitation index (SPI) and standardized precipitation and evapotranspiration index (SPEI) were used to characterize drought while the standardized runoff index (SRI) was used to quantify river flow. Results of the study show that the historical pattern of drought is consistent with previous studies over the Basin and most part of West Africa. RCA4 ensemble gives realistic simulations of the climatology of the Basin in the past climate. Generally, an increase in drought intensity and frequency are projected over NRB. The coupling between SRI and drought indices was very strong (P < 0.05). The dominant peaks can be classified into three distinct drought cycles with periods 1-2, 2-4, 4-8 years. These cycles may be associated with Quasi-Biennial Oscillation (QBO) and El-Nino Southern Oscillation (ENSO). River flow was highly sensitive to precipitation in the NRB and a 1-3 month lead time was found between drought indices and SRI. Under RCP4.5, changes in the SPEI drought frequency range from 1.8 (2046-2065) to 2.4 (2081-2100) month year(-1) while under RCP8.5, the change ranges from 2.2 (2046-2065) to 3.0 month year(-1) (2081-2100). Niger Middle sub-basin is likely to be mostly impacted in the future while the Upper Niger was projected to be least impacted. Results of this study may guide policymakers to evolve strategies to facilitate vulnerability assessment and adaptive capacity of the basin in order to minimize the negative impacts of climate change.}, language = {en} } @article{WutkeSandovalCastellanosBeneckeetal.2018, author = {Wutke, Saskia and Sandoval-Castellanos, Edson and Benecke, Norbert and D{\"o}hle, Hans-J{\"u}rgen and Friederich, Susanne and Gonzalez, Javier and Hofreiter, Michael and Lougas, Lembi and Magnell, Ola and Malaspinas, Anna-Sapfo and Morales-Muniz, Arturo and Orlando, Ludovic and Reissmann, Monika and Trinks, Alexandra and Ludwig, Arne}, title = {Decline of genetic diversity in ancient domestic stallions in Europe}, series = {Science Advances}, volume = {4}, journal = {Science Advances}, number = {4}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {2375-2548}, doi = {10.1126/sciadv.aap9691}, pages = {7}, year = {2018}, abstract = {Present-day domestic horses are immensely diverse in their maternally inherited mitochondrial DNA, yet they show very little variation on their paternally inherited Y chromosome. Although it has recently been shown that Y chromosomal diversity in domestic horses was higher at least until the Iron Age, when and why this diversity disappeared remain controversial questions. We genotyped 16 recently discovered Y chromosomal single-nucleotide polymorphisms in 96 ancient Eurasian stallions spanning the early domestication stages (Copper and Bronze Age) to the Middle Ages. Using this Y chromosomal time series, which covers nearly the entire history of horse domestication, we reveal how Y chromosomal diversity changed over time. Our results also show that the lack of multiple stallion lineages in the extant domestic population is caused by neither a founder effect nor random demographic effects but instead is the result of artificial selection-initially during the Iron Age by nomadic people from the Eurasian steppes and later during the Roman period. Moreover, the modern domestic haplotype probably derived from another, already advantageous, haplotype, most likely after the beginning of the domestication. In line with recent findings indicating that the Przewalski and domestic horse lineages remained connected by gene flow after they diverged about 45,000 years ago, we present evidence for Y chromosomal introgression of Przewalski horses into the gene pool of European domestic horses at least until medieval times.}, language = {en} } @article{WittFrankGillesetal.2018, author = {Witt, Stephanie H. and Frank, Josef and Gilles, Maria and Lang, Maren and Treutlein, Jens and Streit, Fabian and Wolf, Isabell A. C. and Peus, Verena and Scharnholz, Barbara and Send, Tabea S. and Heilmann-Heimbach, Stefanie and Sivalingam, Sugirthan and Dukal, Helene and Strohmaier, Jana and S{\"u}tterlin, Marc and Arloth, Janine and Laucht, Manfred and N{\"o}then, Markus M. and Deuschle, Michael and Rietschel, Marcella}, title = {Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation}, series = {BMC genomics}, volume = {19}, journal = {BMC genomics}, publisher = {BMC}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-018-4652-7}, pages = {10}, year = {2018}, abstract = {Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels. Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females. Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top "smoking methylation pattern" genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns. Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight.}, language = {en} } @article{ZurellvonWehrdenRoticsetal.2018, author = {Zurell, Damaris and von Wehrden, Henrik and Rotics, Shay and Kaatz, Michael and Gross, Helge and Schlag, Lena and Sch{\"a}fer, Merlin and Sapir, Nir and Turjeman, Sondra and Wikelski, Martin and Nathan, Ran and Jeltsch, Florian}, title = {Home range size and resource use of breeding and non-breeding white storks along a land use gradient}, series = {Frontiers in Ecology and Evolution}, volume = {6}, journal = {Frontiers in Ecology and Evolution}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {2296-701X}, doi = {10.3389/fevo.2018.00079}, pages = {11}, year = {2018}, abstract = {Biotelemetry is increasingly used to study animal movement at high spatial and temporal resolution and guide conservation and resource management. Yet, limited sample sizes and variation in space and habitat use across regions and life stages may compromise robustness of behavioral analyses and subsequent conservation plans. Here, we assessed variation in (i) home range sizes, (ii) home range selection, and (iii) fine-scale resource selection of white storks across breeding status and regions and test model transferability. Three study areas were chosen within the Central German breeding grounds ranging from agricultural to fluvial and marshland. We monitored GPS-locations of 62 adult white storks equipped with solar-charged GPS/3D-acceleration (ACC) transmitters in 2013-2014. Home range sizes were estimated using minimum convex polygons. Generalized linear mixed models were used to assess home range selection and fine-scale resource selection by relating the home ranges and foraging sites to Corine habitat variables and normalized difference vegetation index in a presence/pseudo-absence design. We found strong variation in home range sizes across breeding stages with significantly larger home ranges in non-breeding compared to breeding white storks, but no variation between regions. Home range selection models had high explanatory power and well predicted overall density of Central German white stork breeding pairs. Also, they showed good transferability across regions and breeding status although variable importance varied considerably. Fine-scale resource selection models showed low explanatory power. Resource preferences differed both across breeding status and across regions, and model transferability was poor. Our results indicate that habitat selection of wild animals may vary considerably within and between populations, and is highly scale dependent. Thereby, home range scale analyses show higher robustness whereas fine-scale resource selection is not easily predictable and not transferable across life stages and regions. Such variation may compromise management decisions when based on data of limited sample size or limited regional coverage. We thus recommend home range scale analyses and sampling designs that cover diverse regional landscapes and ensure robust estimates of habitat suitability to conserve wild animal populations.}, language = {en} } @article{MunozWeckmannPeketal.2018, author = {Munoz, Gerard and Weckmann, Ute and Pek, Josef and Kovacikova, Svetlana and Klanica, Radek}, title = {Regional two-dimensional magnetotelluric profile in West Bohemia/Vogtland reveals deep conductive channel into the earthquake swarm region}, series = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, volume = {727}, journal = {Tectonophysics : international journal of geotectonics and the geology and physics of the interior of the earth}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0040-1951}, doi = {10.1016/j.tecto.2018.01.012}, pages = {1 -- 11}, year = {2018}, abstract = {The West Bohemia/Vogtland region, characterized by the intersection of the Eger (Ohre) Rift and the Marianske Lazne fault, is a geodynamically active area exhibiting repeated occurrence of earthquake swarms, massive CO2 emanations and mid Pleistocene volcanism. The Eger Rift is the only known intra-continental region in Europe where such deep seated, active lithospheric processes currently take place. We present an image of electrical resistivity obtained from two-dimensional inversion of magnetotelluric (MT) data acquired along a regional profile crossing the Eger Rift. At the near surface, the Cheb basin and the aquifer feeding the mofette fields of Bublak and Hartousov have been imaged as part of a region of very low resistivity. The most striking resistivity feature, however, is a deep reaching conductive channel which extends from the surface into the lower crust spatially correlated with the hypocentres of the seismic events of the Novy Kostel Focal Zone. This channel has been interpreted as imaging a pathway from a possible mid-crustal fluid reservoir to the surface. The resistivity model reinforces the relation between the fluid circulation along deep-reaching faults and the generation of the earthquakes. Additionally, a further conductive channel has been revealed to the south of the profile. This other feature could be associated to fossil hydrothermal alteration related to Mytina and/or Neualbenreuth Maar structures or alternatively could be the signature of a structure associated to the suture between the Saxo-Thuringian and Tepla-Barrandian zones, whose surface expression is located only a few kilometres away.}, language = {en} } @article{MishraPrasadJehangiretal.2018, author = {Mishra, Praveen Kumar and Prasad, Sushma and Jehangir, Arshid and Anoop, Ambili and Yousuf, Abdul R. and Gaye, Birgit}, title = {Investigating the role of meltwater versus precipitation seasonality in abrupt lake-level rise in the high-altitude Tso Moriri Lake (India)}, series = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, volume = {493}, journal = {Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0031-0182}, doi = {10.1016/j.palaeo.2017.12.026}, pages = {20 -- 29}, year = {2018}, abstract = {We present late Quaternary lake level reconstruction from the high altitude Tso Moriri Lake (NW Indian Himalaya) using a combination of new and published data from shallow and deep water cores, and catchment geomorphology. Our reconstruction indicates two dramatic lake level increases - a late glacial (ca. 16.4-12.6 cal kyr B.P.) rise of 65 m, and a 47 m rise during the early Holocene wet phase (ca. 11.2-8.5 cal kyr B.P.) which are separated by the Younger Dryas (YD) event. We decouple the role of precipitation seasonality and snow melt using a combination of proxies sensitive to the Indian Summer Monsoon (ISM), and a regional spatio-temporal transect that provides information on the eastward penetration of the winter westerlies. A comparison of shallow and deep water cores shows that (i) the first lake level increase (similar to 65 m, ca. 16.4-12.6 cal kyr B.P.) is caused by melt water inflow triggered by the increasing summer insolation; (ii) the second lake level increase (similar to 47 m, 11.2-8.5 cal kyr B.P.) is largely caused by a rise in annual precipitation coupled with reduced summer evaporation; (iii) in contrast to the onset of ISM (Bay of Bengal branch) at ca. 14.7 ka in lower elevations in NE India, the hydroclimatic influence of ISM in the high altitude Himalaya is seen only between 12.7 and 12 cal kyr B.P., though the influence of solar insolation (via increased snowmelt) is visible from 16.4 cal kyr B.P. onwards; (iv) the eastward penetration of westerlies in Indian Himalayas is strongly influenced by the strength of the Siberian High.}, language = {en} } @article{SaremAryaHeizmannetal.2018, author = {Sarem, Melika and Arya, Neha and Heizmann, Miriam and Neffe, Axel T. and Barbero, Andrea and Gebauer, Tim P. and Martin, Ivan and Lendlein, Andreas and Shastri, V. Prasad}, title = {Interplay between stiffness and degradation of architectured gelatin hydrogels leads to differential modulation of chondrogenesis in vitro and in vivo}, series = {Acta biomaterialia}, volume = {69}, journal = {Acta biomaterialia}, publisher = {Elsevier}, address = {Oxford}, issn = {1742-7061}, doi = {10.1016/j.actbio.2018.01.025}, pages = {83 -- 94}, year = {2018}, abstract = {The limited capacity of cartilage to heal large lesions through endogenous mechanisms has led to extensive effort to develop materials to facilitate chondrogenesis. Although physical-chemical properties of biomaterials have been shown to impact in vitro chondrogenesis, whether these findings are translatable in vivo is subject of debate. Herein, architectured 3D hydrogel scaffolds (ArcGel) (produced by crosslinking gelatin with ethyl lysine diisocyanate (LDI)) were used as a model system to investigate the interplay between scaffold mechanical properties and degradation on matrix deposition by human articular chondrocytes (HAC) from healthy donors in vitro and in vivo. Using ArcGel scaffolds of different tensile and shear modulus, and degradation behavior; in this study, we compared the fate of ex vivo engineeredArcGels-chondrocytes constructs, i.e. the traditional tissue engineering approach, with the de novo formation of cartilaginous tissue in HAC laden ArcGels in an ectopic nude mouse model. While the softer and fast degrading ArcGel (LNCO3) was more efficient at promoting chondrogenic differentiation in vitro, upon ectopic implantation, the stiffer and slow degrading ArcGel (LNCO8) was superior in maintaining chondrogenic phenotype in HAC and retention of cartilaginous matrix. Furthermore, surprisingly the de novo formation of cartilage tissue was promoted only in LNCO8. Since HAC cultured for only three days in the LNCO8 environment showed upregulation of hypoxia-associated genes, this suggests a potential role for hypoxia in the observed in vivo outcomes. In summary, this study sheds light on how immediate environment (in vivo versus in vitro) can significantly impact the outcomes of cell-laden biomaterials. Statement of Significance In this study, 3D architectured hydrogels (ArcGels) with different mechanical and biodegradation properties were investigated for their potential to promote formation of cartilaginous matrix by human articular chondrocytes in vitro and in vivo. Two paradigms were explored (i) ex vivo engineering followed by in vivo implantation in ectopic site of nude mice and (ii) short in vitro culture (3 days) followed by implantation to induce de novo cartilage formation. Softer and fast degrading ArcGel were better at promoting chondrogenesis in vitro, while stiffer and slow degrading ArcGel were strikingly superior in both maintaining chondrogenesis in vivo and inducing de novo formation of cartilage. Our findings highlight the importance of the interplay between scaffold mechanics and degradation in chondrogenesis.}, language = {en} } @article{PeterPikovskij2018, author = {Peter, Franziska and Pikovskij, Arkadij}, title = {Transition to collective oscillations in finite Kuramoto ensembles}, series = {Physical review : E, Statistical, nonlinear and soft matter physics}, volume = {97}, journal = {Physical review : E, Statistical, nonlinear and soft matter physics}, number = {3}, publisher = {American Physical Society}, address = {College Park}, issn = {2470-0045}, doi = {10.1103/PhysRevE.97.032310}, pages = {10}, year = {2018}, abstract = {We present an alternative approach to finite-size effects around the synchronization transition in the standard Kuramoto model. Our main focus lies on the conditions under which a collective oscillatory mode is well defined. For this purpose, the minimal value of the amplitude of the complex Kuramoto order parameter appears as a proper indicator. The dependence of this minimum on coupling strength varies due to sampling variations and correlates with the sample kurtosis of the natural frequency distribution. The skewness of the frequency sample determines the frequency of the resulting collective mode. The effects of kurtosis and skewness hold in the thermodynamic limit of infinite ensembles. We prove this by integrating a self-consistency equation for the complex Kuramoto order parameter for two families of distributions with controlled kurtosis and skewness, respectively.}, language = {en} } @article{ChengKliemDing2018, author = {Cheng, Xin and Kliem, Bernhard and Ding, Mingde}, title = {Unambiguous evidence of filament splitting-induced partial eruptions}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {856}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/1538-4357/aab08d}, pages = {15}, year = {2018}, abstract = {Coronal mass ejections are often considered to result from the full eruption of a magnetic flux rope (MFR). However, it is recognized that, in some events, the MFR may release only part of its flux, with the details of the implied splitting not completely established due to limitations in observations. Here, we investigate two partial eruption events including a confined and a successful one. Both partial eruptions are a consequence of the vertical splitting of a filament-hosting MFR involving internal reconnection. A loss of equilibrium in the rising part of the magnetic flux is suggested by the impulsive onset of both events and by the delayed onset of reconnection in the confined event. The remaining part of the flux might be line-tied to the photosphere in a bald patch (BP) separatrix surface, and we confirm the existence of extended BP sections for the successful eruption. The internal reconnection is signified by brightenings in the body of one filament and between the rising and remaining parts of both filaments. It evolves quickly into the standard current sheet reconnection in the wake of the eruption. As a result, regardless of being confined or successful, both eruptions produce hard X-ray sources and flare loops below the erupting but above the surviving flux, as well as a pair of flare ribbons enclosing the latter.}, language = {en} } @article{DierckeKuckeinVermaetal.2018, author = {Diercke, Andrea and Kuckein, Christoph and Verma, Meetu and Denker, Carsten}, title = {Counter-streaming flows in a giant quiet-Sun filament observed in the extreme ultraviolet}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {611}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201730536}, pages = {11}, year = {2018}, abstract = {Aims. The giant solar filament was visible on the solar surface from 2011 November 8-23. Multiwavelength data from the Solar Dynamics Observatory (SDO) were used to examine counter-streaming flows within the spine of the filament. Methods. We use data from two SDO instruments, the Atmospheric Imaging Assembly (AIA) and the Helioseismic and Magnetic Imager (HMI), covering the whole filament, which stretched over more than half a solar diameter. H alpha images from the Kanzelhohe Solar Observatory (KSO) provide context information of where the spine of the filament is defined and the barbs are located. We apply local correlation tracking (LCT) to a two-hour time series on 2011 November 16 of the AIA images to derive horizontal flow velocities of the filament. To enhance the contrast of the AIA images, noise adaptive fuzzy equalization (NAFE) is employed, which allows us to identify and quantify counter-streaming flows in the filament. We observe the same cool filament plasma in absorption in both H alpha and EUV images. Hence, the counter-streaming flows are directly related to this filament material in the spine. In addition, we use directional flow maps to highlight the counter-streaming flows. Results. We detect counter-streaming flows in the filament, which are visible in the time-lapse movies in all four examined AIA wavelength bands (lambda 171 angstrom, lambda 193 angstrom, lambda 304 angstrom, and lambda 211 angstrom). In the time-lapse movies we see that these persistent flows lasted for at least two hours, although they became less prominent towards the end of the time series. Furthermore, by applying LCT to the images we clearly determine counter-streaming flows in time series of lambda 171 angstrom and lambda 193 angstrom images. In the lambda 304 angstrom wavelength band, we only see minor indications for counter-streaming flows with LCT, while in the lambda 211 angstrom wavelength band the counter-streaming flows are not detectable with this method. The diverse morphology of the filament in H alpha and EUV images is caused by different absorption processes, i.e., spectral line absorption and absorption by hydrogen and helium continua, respectively. The horizontal flows reach mean flow speeds of about 0.5 km s(-1) for all wavelength bands. The highest horizontal flow speeds are identified in the lambda 171 angstrom band with flow speeds of up to 2.5 km s(-1). The results are averaged over a time series of 90 minutes. Because the LCT sampling window has finite width, a spatial degradation cannot be avoided leading to lower estimates of the flow velocities as compared to feature tracking or Doppler measurements. The counter-streaming flows cover about 15-20\% of the whole area of the EUV filament channel and are located in the central part of the spine. Conclusions. Compared to the ground-based observations, the absence of seeing effects in AIA observations reveal counter-streaming flows in the filament even with a moderate image scale of 0 '.6 pixel(-1). Using a contrast enhancement technique, these flows can be detected and quantified with LCT in different wavelengths. We confirm the omnipresence of counter-streaming flows also in giant quiet-Sun filaments.}, language = {en} } @article{GoodwinMuddClubb2018, author = {Goodwin, Guillaume C. H. and Mudd, Simon M. and Clubb, Fiona J.}, title = {Unsupervised detection of salt marsh platforms}, series = {Earth surface dynamics}, volume = {6}, journal = {Earth surface dynamics}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2196-6311}, doi = {10.5194/esurf-6-239-2018}, pages = {239 -- 255}, year = {2018}, abstract = {Salt marshes filter pollutants, protect coastlines against storm surges, and sequester carbon, yet are under threat from sea level rise and anthropogenic modification. The sustained existence of the salt marsh ecosystem depends on the topographic evolution of marsh platforms. Quantifying marsh platform topography is vital for improving the management of these valuable landscapes. The determination of platform boundaries currently relies on supervised classification methods requiring near-infrared data to detect vegetation, or demands labour-intensive field surveys and digitisation. We propose a novel, unsupervised method to reproducibly isolate salt marsh scarps and platforms from a digital elevation model (DEM), referred to as Topographic Identification of Platforms (TIP). Field observations and numerical models show that salt marshes mature into subhorizontal platforms delineated by subvertical scarps. Based on this premise, we identify scarps as lines of local maxima on a slope raster, then fill landmasses from the scarps upward, thus isolating mature marsh platforms. We test the TIP method using lidar-derived DEMs from six salt marshes in England with varying tidal ranges and geometries, for which topographic platforms were manually isolated from tidal flats. Agreement between manual and unsupervised classification exceeds 94\% for DEM resolutions of 1 m, with all but one site maintaining an accuracy superior to 90\% for resolutions up to 3 m. For resolutions of 1 m, platforms detected with the TIP method are comparable in surface area to digitised platforms and have similar elevation distributions. We also find that our method allows for the accurate detection of local block failures as small as 3 times the DEM resolution. Detailed inspection reveals that although tidal creeks were digitised as part of the marsh platform, unsupervised classification categorises them as part of the tidal flat, causing an increase in false negatives and overall platform perimeter. This suggests our method may benefit from combination with existing creek detection algorithms. Fallen blocks and high tidal flat portions, associated with potential pioneer zones, can also lead to differences between our method and supervised mapping. Although pioneer zones prove difficult to classify using a topographic method, we suggest that these transition areas should be considered when analysing erosion and accretion processes, particularly in the case of incipient marsh platforms. Ultimately, we have shown that unsupervised classification of marsh platforms from high-resolution topography is possible and sufficient to monitor and analyse topographic evolution.}, language = {en} } @article{NeugartWiesnerReinholdFredeetal.2018, author = {Neugart, Susanne and Wiesner-Reinhold, Melanie and Frede, Katja and Jander, Elisabeth and Homann, Thomas and Rawel, Harshadrai Manilal and Schreiner, Monika and Baldermann, Susanne}, title = {Effect of Solid Biological Waste Compost on the Metabolite Profile of Brassica rapa ssp chinensis}, series = {Frontiers in plant science : FPLS}, volume = {9}, journal = {Frontiers in plant science : FPLS}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2018.00305}, pages = {13}, year = {2018}, abstract = {Large quantities of biological waste are generated at various steps within the food production chain and a great utilization potential for this solid biological waste exists apart from the current main usage for the feedstuff sector. It remains unclear how the usage of biological waste as compost modulates plant metabolites. We investigated the effect of biological waste of the processing of coffee, aronia, and hop added to soil on the plant metabolite profile by means of liquid chromatography in pak choi sprouts. Here we demonstrate that the solid biological waste composts induced specific changes in the metabolite profiles and the changes are depending on the type of the organic residues and its concentration in soil. The targeted analysis of selected plant metabolites, associated with health beneficial properties of the Brassicaceae family, revealed increased concentrations of carotenoids (up to 3.2-fold) and decreased amounts of glucosinolates (up to 4.7-fold) as well as phenolic compounds (up to 1.5-fold).}, language = {en} } @article{LeeWhiteLiuetal.2018, author = {Lee, Jeongwoo and White, Stephen M. and Liu, Chang and Kliem, Bernhard and Masuda, Satoshi}, title = {Magnetic Structure of a Composite Solar Microwave Burst}, series = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, volume = {856}, journal = {The astrophysical journal : an international review of spectroscopy and astronomical physics}, number = {1}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-637X}, doi = {10.3847/1538-4357/aaadbc}, pages = {10}, year = {2018}, abstract = {A composite flare consisting of an impulsive flare SOL2015-06-21T01:42 (GOES class M2.0) and a more gradual, long-duration flare SOL2015-06-21T02:36 (M2.6) from NOAA Active Region 12371, is studied using observations with the Nobeyama Radioheliograph (NoRH) and the Solar Dynamics Observatory (SDO). While composite flares are defined by their characteristic time profiles, in this paper we present imaging observations that demonstrate the spatial relationship of the two flares and allow us to address the nature of the evolution of a composite event. The NoRH maps show that the first flare is confined not only in time, but also in space, as evidenced by the stagnation of ribbon separation and the stationarity of the microwave source. The NoRH also detected another microwave source during the second flare, emerging from a different location where thermal plasma is so depleted that accelerated electrons could survive longer against Coulomb collisional loss. The AIA 131 angstrom images show that a sigmoidal EUV hot channel developed after the first flare and erupted before the second flare. We suggest that this eruption removed the high-lying flux to let the separatrix dome underneath reconnect with neighboring flux and the second microwave burst follow. This scenario explains how the first microwave burst is related to the much-delayed second microwave burst in this composite event.}, language = {en} } @article{MorHerzogNoacketal.2018, author = {Mor, Selene and Herzog, Marc and Noack, Johannes and Katayama, Naoyuki and Nohara, Minoru and Takagi, Hide and Trunschke, Annette and Mizokawa, Takashi and Monney, Claude and St{\"a}hler, Julia}, title = {Inhibition of the photoinduced structural phase transition in the excitonic insulator Ta2NiSe5}, series = {Physical review : B, Condensed matter and materials physics}, volume = {97}, journal = {Physical review : B, Condensed matter and materials physics}, number = {11}, publisher = {American Physical Society}, address = {College Park}, issn = {2469-9950}, doi = {10.1103/PhysRevB.97.115154}, pages = {5}, year = {2018}, abstract = {Femtosecond time-resolved midinfrared reflectivity is used to investigate the electron and phonon dynamics occurring at the direct band gap of the excitonic insulator Ta2NiSe5 below the critical temperature of its structural phase transition. We find that the phonon dynamics show a strong coupling to the excitation of free carriers at the Gamma point of the Brillouin zone. The optical response saturates at a critical excitation fluence F-C = 0.30 +/- 0.08 mJ/cm(2) due to optical absorption saturation. This limits the optical excitation density in Ta2NiSe5 so that the system cannot be pumped sufficiently strongly to undergo the structural change to the high-temperature phase. We thereby demonstrate that Ta2NiSe5 exhibits a blocking mechanism when pumped in the near-infrared regime, preventing a nonthermal structural phase transition.}, language = {en} } @article{RackwitzBald2018, author = {Rackwitz, Jenny and Bald, Ilko}, title = {Low-energy electron-induced strand breaks in telomere-derived DNA sequences}, series = {Chemistry - a European journal}, volume = {24}, journal = {Chemistry - a European journal}, number = {18}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0947-6539}, doi = {10.1002/chem.201705889}, pages = {4680 -- 4688}, year = {2018}, abstract = {During cancer radiation therapy high-energy radiation is used to reduce tumour tissue. The irradiation produces a shower of secondary low-energy (<20 eV) electrons, which are able to damage DNA very efficiently by dissociative electron attachment. Recently, it was suggested that low-energy electron-induced DNA strand breaks strongly depend on the specific DNA sequence with a high sensitivity of G-rich sequences. Here, we use DNA origami platforms to expose G-rich telomere sequences to low-energy (8.8 eV) electrons to determine absolute cross sections for strand breakage and to study the influence of sequence modifications and topology of telomeric DNA on the strand breakage. We find that the telomeric DNA 5′-(TTA GGG)2 is more sensitive to low-energy electrons than an intermixed sequence 5′-(TGT GTG A)2 confirming the unique electronic properties resulting from G-stacking. With increasing length of the oligonucleotide (i.e., going from 5′-(GGG ATT)2 to 5′-(GGG ATT)4), both the variety of topology and the electron-induced strand break cross sections increase. Addition of K+ ions decreases the strand break cross section for all sequences that are able to fold G-quadruplexes or G-intermediates, whereas the strand break cross section for the intermixed sequence remains unchanged. These results indicate that telomeric DNA is rather sensitive towards low-energy electron-induced strand breakage suggesting significant telomere shortening that can also occur during cancer radiation therapy.}, language = {en} } @article{GarcinDeschampsMenotetal.2018, author = {Garcin, Yannick and Deschamps, Pierre and Menot, Guillemette and de Saulieu, Geoffroy and Schefuss, Enno and Sebag, David and Dupont, Lydie M. and Oslisly, Richard and Brademann, Brian and Mbusnum, Kevin G. and Onana, Jean-Michel and Ako, Andrew A. and Epp, Laura Saskia and Tjallingii, Rik and Strecker, Manfred and Brauer, Achim and Sachse, Dirk}, title = {Early anthropogenic impact on Western Central African rainforests 2,600 y ago}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {115}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {13}, publisher = {National Acad. of Sciences}, address = {Washington}, issn = {0027-8424}, doi = {10.1073/pnas.1715336115}, pages = {3261 -- 3266}, year = {2018}, abstract = {A potential human footprint on Western Central African rainforests before the Common Era has become the focus of an ongoing controversy. Between 3,000 y ago and 2,000 y ago, regional pollen sequences indicate a replacement of mature rainforests by a forest-savannah mosaic including pioneer trees. Although some studies suggested an anthropogenic influence on this forest fragmentation, current interpretations based on pollen data attribute the "rainforest crisis" to climate change toward a drier, more seasonal climate. A rigorous test of this hypothesis, however, requires climate proxies independent of vegetation changes. Here we resolve this controversy through a continuous 10,500-y record of both vegetation and hydrological changes from Lake Barombi in Southwest Cameroon based on changes in carbon and hydrogen isotope compositions of plant waxes. delta C-13-inferred vegetation changes confirm a prominent and abrupt appearance of C-4 plants in the Lake Barombi catchment, at 2,600 calendar years before AD 1950 (cal y BP), followed by an equally sudden return to rainforest vegetation at 2,020 cal y BP. delta D values from the same plant wax compounds, however, show no simultaneous hydrological change. Based on the combination of these data with a comprehensive regional archaeological database we provide evidence that humans triggered the rainforest fragmentation 2,600 y ago. Our findings suggest that technological developments, including agricultural practices and iron metallurgy, possibly related to the large-scale Bantu expansion, significantly impacted the ecosystems before the Common Era.}, language = {en} } @article{ZimmermannJohnGrigorievetal.2018, author = {Zimmermann, Marc and John, Daniela and Grigoriev, Dmitry and Puretskiy, Nikolay and B{\"o}ker, Alexander}, title = {From 2D to 3D patches on multifunctional particles}, series = {Soft matter}, volume = {14}, journal = {Soft matter}, number = {12}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c8sm00163d}, pages = {2301 -- 2309}, year = {2018}, abstract = {A straightforward approach for the precise multifunctional surface modification of particles with three-dimensional patches using microcontact printing is presented. By comparison to previous works it was possible to not only control the diameter, but also to finely tune the thickness of the deposited layer, opening up the way for three-dimensional structures and orthogonal multifunctionality. The use of PEI as polymeric ink, PDMS stamps for microcontact printing on silica particles and the influence of different solvents during particle release on the creation of functional particles with three-dimensional patches are described. Finally, by introducing fluorescent properties by incorporation of quantum dots into patches and by particle self-assembly via avidin-biotin coupling, the versatility of this novel modification method is demonstrated.}, language = {en} } @article{BraunGemignanivanderBeek2018, author = {Braun, Jean and Gemignani, Lorenzo and van der Beek, Pieter A.}, title = {Extracting information on the spatial variability in erosion rate stored in detrital cooling age distributions in river sands}, series = {Earth surface dynamics}, volume = {6}, journal = {Earth surface dynamics}, number = {1}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2196-6311}, doi = {10.5194/esurf-6-257-2018}, pages = {257 -- 270}, year = {2018}, abstract = {One of the main purposes of detrital thermochronology is to provide constraints on the regional-scale exhumation rate and its spatial variability in actively eroding mountain ranges. Procedures that use cooling age distributions coupled with hypsometry and thermal models have been developed in order to extract quantitative estimates of erosion rate and its spatial distribution, assuming steady state between tectonic uplift and erosion. This hypothesis precludes the use of these procedures to assess the likely transient response of mountain belts to changes in tectonic or climatic forcing. Other methods are based on an a priori knowledge of the in situ distribution of ages to interpret the detrital age distributions. In this paper, we describe a simple method that, using the observed detrital mineral age distributions collected along a river, allows us to extract information about the relative distribution of erosion rates in an eroding catchment without relying on a steady-state assumption, the value of thermal parameters or an a priori knowledge of in situ age distributions. The model is based on a relatively low number of parameters describing lithological variability among the various sub-catchments and their sizes and only uses the raw ages. The method we propose is tested against synthetic age distributions to demonstrate its accuracy and the optimum conditions for it use. In order to illustrate the method, we invert age distributions collected along the main trunk of the Tsangpo-Siang-Brahmaputra river system in the eastern Himalaya. From the inversion of the cooling age distributions we predict present-day erosion rates of the catchments along the Tsangpo-Siang-Brahmaputra river system, as well as some of its tributaries. We show that detrital age distributions contain dual information about present-day erosion rate, i. e., from the predicted distribution of surface ages within each catchment and from the relative contribution of any given catchment to the river distribution. The method additionally allows comparing modern erosion rates to long-term exhumation rates. We provide a simple implementation of the method in Python code within a Jupyter Notebook that includes the data used in this paper for illustration purposes.}, language = {en} } @article{HeidenYueKirschetal.2018, author = {Heiden, Sophia and Yue, Yanhua and Kirsch, Harald and Wirth, Jonas A. and Saalfrank, Peter and Campen, Richard Kramer}, title = {Water dissociative adsorption on α-Al2O3(112̅0) is controlled by surface site undercoordination, density, and topology}, series = {The journal of physical chemistry / publ. weekly by the American Chemical Society : C, Nanomaterials and interfaces}, volume = {122}, journal = {The journal of physical chemistry / publ. weekly by the American Chemical Society : C, Nanomaterials and interfaces}, number = {12}, publisher = {American Chemical Society}, address = {Washington}, issn = {1932-7447}, doi = {10.1021/acs.jpcc.7b10410}, pages = {6573 -- 6584}, year = {2018}, abstract = {α-Al2O3 surfaces are common in a wide variety of applications and useful models of more complicated, environmentally abundant, alumino-silicate surfaces. While decades of work have clarified that all properties of these surfaces depend sensitively on the crystal face and the presence of even small amounts of water, quantitative insight into this dependence has proven challenging. Overcoming this challenge requires systematic study of the mechanism by which water interacts with various α-Al2O3 surfaces. Such insight is most easily gained for the interaction of small amounts of water with surfaces in ultra high vacuum. In this study, we continue our combined theoretical and experimental approach to this problem, previously applied to water interaction with the α-Al2O3 (0001) and (11̅02) surfaces, now to water interaction with the third most stable surface, that is, the (112̅0). Because we characterize all three surfaces using similar tools, it is straightforward to conclude that the (112̅0) is most reactive with water. The most important factor explaining its increased reactivity is that the high density of undercoordinated surface Al atoms on the (112̅0) surface allows the bidentate adsorption of OH fragments originating from dissociatively adsorbed water, while only monodentate adsorption is possible on the (0001) and (11̅02) surfaces: the reactivity of α-Al2O3 surfaces with water depends strongly, and nonlinearly, on the density of undercoordinated surface Al atoms.}, language = {en} } @article{NellesenLaquaiMuelleretal.2018, author = {Nellesen, Jens and Laquai, R. and M{\"u}ller, B. R. and Kupsch, Andreas and Hentschel, M. P. and Anar, N. B. and Soppa, E. and Tillmann, W. and Bruno, Giovanni}, title = {In situ analysis of damage evolution in an Al/ Al2O3 MMC under tensile load by synchrotron X-ray refraction imaging}, series = {Journal of materials science}, volume = {53}, journal = {Journal of materials science}, number = {8}, publisher = {Springer}, address = {New York}, issn = {0022-2461}, doi = {10.1007/s10853-017-1957-x}, pages = {6021 -- 6032}, year = {2018}, abstract = {The in situ analysis of the damage evolution in a metal matrix composite (MMC) using synchrotron X-ray refraction radiography (SXRR) is presented. The investigated material is an Al alloy (6061)/10 vol MMC after T6 heat treatment. In an interrupted tensile test the gauge section of dog bone-shaped specimens is imaged in different states of tensile loading. On the basis of the SXRR images, the relative change of the specific surface (proportional to the amount of damage) in the course of tensile loading was analyzed. It could be shown that the damage can be detected by SXRR already at a stage of tensile loading, in which no observation of damage is possible with radiographic absorption-based imaging methods. Moreover, the quantitative analysis of the SXRR images reveals that the amount of damage increases homogeneously by an average of 25\% with respect to the initial state. To corroborate the experimental findings, the damage distribution was imaged in 3D after the final tensile loading by synchrotron X-ray refraction computed tomography (SXRCT) and absorption-based synchrotron X-ray computed tomography (SXCT). It could be evidenced that defects and damages cause pronounced indications in the SXRCT images.}, language = {en} } @article{BorckBrueckner2018, author = {Borck, Rainald and Brueckner, Jan K.}, title = {Optimal energy taxation in cities}, series = {Journal of the Association of Environmental and Resource Economists : JAERE}, volume = {5}, journal = {Journal of the Association of Environmental and Resource Economists : JAERE}, number = {2}, publisher = {University of Chicago Press}, address = {Chicago}, issn = {2333-5955}, doi = {10.1086/695614}, pages = {481 -- 516}, year = {2018}, abstract = {This paper presents the first investigation of the effects of optimal energy taxation in an urban spatial setting, where emissions are produced both by residences and commuting. When levying an optimal direct tax on energy or carbon use is not feasible, the analysis shows that exactly the same adjustments in resource allocation can be generated by the combination of a land tax, a housing tax, and a commuting tax. We then analyze the effects of these taxes on urban spatial structure, showing that they reduce the extent of commuting and the level of housing consumption while increasing building heights, generating a more-compact city with a lower level of emissions per capita.}, language = {en} } @article{GonzalezGalanOskinovaPopovetal.2018, author = {Gonz{\´a}lez-Gal{\´a}n, Ana and Oskinova, Lidia M. and Popov, Sergei B. and Haberl, F. and K{\"u}hnel, M. and Gallagher, John S. and Schurch, Matthew and Guerrero, Mart{\´i}n A.}, title = {A multiwavelength study of SXP 1062, the long-period X-ray pulsar associated with a supernova remnant}, series = {Monthly notices of the Royal Astronomical Society}, volume = {475}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stx3127}, pages = {2809 -- 2821}, year = {2018}, abstract = {SXP 1062 is a Be X-ray binary (BeXB) located in the Small Magellanic Cloud. It hosts a long-period X-ray pulsar and is likely associated with the supernova remnant MCSNR J0127-7332. In this work we present a multiwavelength view on SXP 1062 in different luminosity regimes. We consider monitoring campaigns in optical (OGLE survey) and X-ray (Swift telescope). During these campaigns a tight coincidence of X-ray and optical outbursts is observed. We interpret this as typical Type I outbursts as often detected in BeXBs at periastron passage of the neutron star (NS). To study different X-ray luminosity regimes in depth, during the source quiescence we observed it with XMM-Newton while Chandra observations followed an X-ray outburst. Nearly simultaneously with Chandra observations in X-rays, in optical the RSS/SALT telescope obtained spectra of SXP 1062. On the basis of our multiwavelength campaign we propose a simple scenario where the disc of the Be star is observed face-on, while the orbit of the NS is inclined with respect to the disc. According to the model of quasi-spherical settling accretion our estimation of the magnetic field of the pulsar in SXP 1062 does not require an extremely strong magnetic field at the present time.}, language = {en} } @article{ZhangYan2018, author = {Zhang, Heshou and Yan, Huirong}, title = {Polarization of submillimetre lines from interstellar medium}, series = {Monthly notices of the Royal Astronomical Society}, volume = {475}, journal = {Monthly notices of the Royal Astronomical Society}, number = {2}, publisher = {Oxford University Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stx3164}, pages = {2415 -- 2420}, year = {2018}, abstract = {Magnetic fields play important roles in many astrophysical processes. However, there is no universal diagnostic for the magnetic fields in the interstellar medium (ISM) and each magnetic tracer has its limitation. Any new detection method is thus valuable. Theoretical studies have shown that submillimetre fine-structure lines are polarized due to atomic alignment by ultraviolet photon-excitation, which opens up a new avenue to probe interstellar magnetic fields. We will, for the first time, perform synthetic observations on the simulated three-dimensional ISM to demonstrate the measurability of the polarization of submillimetre atomic lines. The maximum polarization for different absorption and emission lines expected from various sources, including star-forming regions are provided. Our results demonstrate that the polarization of submillimetre atomic lines is a powerful magnetic tracer and add great value to the observational studies of the submilimetre astronomy.}, language = {en} } @article{JaegerGraupnerPelchenetal.2018, author = {Jaeger, David and Graupner, Hendrik and Pelchen, Chris and Cheng, Feng and Meinel, Christoph}, title = {Fast Automated Processing and Evaluation of Identity Leaks}, series = {International journal of parallel programming}, volume = {46}, journal = {International journal of parallel programming}, number = {2}, publisher = {Springer}, address = {New York}, issn = {0885-7458}, doi = {10.1007/s10766-016-0478-6}, pages = {441 -- 470}, year = {2018}, abstract = {The relevance of identity data leaks on the Internet is more present than ever. Almost every week we read about leakage of databases with more than a million users in the news. Smaller but not less dangerous leaks happen even multiple times a day. The public availability of such leaked data is a major threat to the victims, but also creates the opportunity to learn not only about security of service providers but also the behavior of users when choosing passwords. Our goal is to analyze this data and generate knowledge that can be used to increase security awareness and security, respectively. This paper presents a novel approach to the processing and analysis of a vast majority of bigger and smaller leaks. We evolved from a semi-manual to a fully automated process that requires a minimum of human interaction. Our contribution is the concept and a prototype implementation of a leak processing workflow that includes the extraction of digital identities from structured and unstructured leak-files, the identification of hash routines and a quality control to ensure leak authenticity. By making use of parallel and distributed programming, we are able to make leaks almost immediately available for analysis and notification after they have been published. Based on the data collected, this paper reveals how easy it is for criminals to collect lots of passwords, which are plain text or only weakly hashed. We publish those results and hope to increase not only security awareness of Internet users but also security on a technical level on the service provider side.}, language = {en} } @article{MelinParraGuillenHartungetal.2018, author = {Melin, Johanna and Parra-Guillen, Zinnia Patricia and Hartung, Niklas and Huisinga, Wilhelm and Ross, Richard J. and Whitaker, Martin J. and Kloft, Charlotte}, title = {Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults}, series = {Clinical Pharmacokinetics}, volume = {57}, journal = {Clinical Pharmacokinetics}, number = {4}, publisher = {Springer}, address = {Northcote}, issn = {0312-5963}, doi = {10.1007/s40262-017-0575-8}, pages = {515 -- 527}, year = {2018}, abstract = {Background and objective Optimisation of hydrocortisone replacement therapy in children is challenging as there is currently no licensed formulation and dose in Europe for children under 6 years of age. In addition, hydrocortisone has non-linear pharmacokinetics caused by saturable plasma protein binding. A paediatric hydrocortisone formulation, Infacort (R) oral hydrocortisone granules with taste masking, has therefore been developed. The objective of this study was to establish a population pharmacokinetic model based on studies in healthy adult volunteers to predict hydrocortisone exposure in paediatric patients with adrenal insufficiency. Methods Cortisol and binding protein concentrations were evaluated in the absence and presence of dexamethasone in healthy volunteers (n = 30). Dexamethasone was used to suppress endogenous cortisol concentrations prior to and after single doses of 0.5, 2, 5 and 10 mg of Infacort (R) or 20 mg of Infacort (R)/hydrocortisone tablet/hydrocortisone intravenously. A plasma protein binding model was established using unbound and total cortisol concentrations, and sequentially integrated into the pharmacokinetic model. Results Both specific (non-linear) and non-specific (linear) protein binding were included in the cortisol binding model. A two-compartment disposition model with saturable absorption and constant endogenous cortisol baseline (Baseline (cort),15.5 nmol/L) described the data accurately. The predicted cortisol exposure for a given dose varied considerably within a small body weight range in individuals weighing < 20 kg. Conclusions Our semi-mechanistic population pharmacokinetic model for hydrocortisone captures the complex pharmacokinetics of hydrocortisone in a simplified but comprehensive framework. The predicted cortisol exposure indicated the importance of defining an accurate hydrocortisone dose to mimic physiological concentrations for neonates and infants weighing < 20 kg.}, language = {en} } @article{EichlerSalzwedelHarnathetal.2018, author = {Eichler, Sarah and Salzwedel, Annett and Harnath, Axel and Butter, Christian and Wegscheider, Karl and Chiorean, Mihai and V{\"o}ller, Heinz and Reibis, Rona Katharina}, title = {Nutrition and mobility predict all-cause mortality in patients 12 months after transcatheter aortic valve implantation}, series = {Clinical research in cardiology : official journal of the German Cardiac Society.}, volume = {107}, journal = {Clinical research in cardiology : official journal of the German Cardiac Society.}, number = {4}, publisher = {Springer}, address = {Heidelberg}, issn = {1861-0684}, doi = {10.1007/s00392-017-1183-1}, pages = {304 -- 311}, year = {2018}, abstract = {The aim of the study was to determine pre-interventional predictors for all-cause mortality in patients after transcatheter aortic valve implantation (TAVI) with a 12-month follow-up. From 10/2013 to 07/2015, 344 patients (80.9 +/- 5.0 years, 44.5\% male) with an elective TAVI were consecutively enrolled prospectively in a multicentre cohort study. Prior to the intervention, sociodemographic parameters, echocardiographic data and comorbidities were documented. All patients performed a 6-min walk test, Short Form 12 and a Frailty Index (score consisting of activities of daily living, cognition, nutrition and mobility). Peri-interventional complications were documented. Vital status was assessed over telephone 12 months after TAVI. Predictors for all-cause mortality were identified using a multivariate regression model. At discharge, 333 patients were alive (in-hospital mortality 3.2\%; n = 11). During a follow-up of 381.0 +/- 41.9 days, 46 patients (13.8\%) died. The non-survivors were older (82.3 +/- 5.0 vs. 80.6 +/- 5.1 years; p = 0.035), had a higher number of comorbidities (2.6 +/- 1.3 vs. 2.1 +/- 1.3; p = 0.026) and a lower left ventricular ejection fraction (51.0 +/- 13.6 vs. 54.6 +/- 10.6\%; p = 0.048). Additionally, more suffered from diabetes mellitus (60.9 vs. 44.6\%; p = 0.040). While the global Frailty Index had no predictive power, its individual components, particularly nutrition (OR 0.83 per 1 pt., CI 0.72-0.95; p = 0.006) and mobility (OR 5.12, CI 1.64-16.01; p = 0.005) had a prognostic impact. Likewise, diabetes mellitus (OR 2.18, CI 1.10-4.32; p = 0.026) and EuroSCORE (OR 1.21 per 5\%, CI 1.07-1.36; p = 0.002) were associated with a higher risk of all-cause mortality. Besides EuroSCORE and diabetes mellitus, nutrition status and mobility of patients scheduled for TAVI offer prognostic information for 1-year all-cause mortality and should be advocated in the creation of contemporary TAVI risk scores.}, language = {en} } @article{FritzEhlertLeutner2018, author = {Fritz, Annemarie and Ehlert, Antje and Leutner, Detlev}, title = {Arithmetische Konzepte aus kognitiv-entwicklungspsychologischer Sicht}, series = {Journal f{\"u}r Mathematik-Didaktik}, volume = {39}, journal = {Journal f{\"u}r Mathematik-Didaktik}, number = {1}, publisher = {Springer}, address = {Heidelberg}, issn = {0173-5322}, doi = {10.1007/s13138-018-0131-6}, pages = {7 -- 41}, year = {2018}, abstract = {The acquisition of basic arithmetic concepts of children at pre-school and primary-school age (about 4 to 8 years of age) can be described by a cognitive developmental model with 6 levels: (1) count number, (2) mental number line, (3) cardinality and decomposability, (4) class inclusion and embeddedness, (5) relationality, and (6) units in numbers (bundling and unbundling). In this paper, 3 studies for longitudinally testing the model are presented. In Studies 1 (N = 26; heterogeneous age) and 2 (N = 62; homogeneous age) it shows that the individual development of arithmetic concepts across 18 months (Study 1:4 points of measurement) respectively 17 months (Study 2:3 points of measurement before, at, and after entering primary school) follows the levels of the model. In Study 3 (N = 243) it shows that the acquisition of curricular mathematical competencies at the end of Grade 2 is better predicted by conceptual arithmetic understanding at the end of Grade 1 than by intelligence. The results substantiate the validity of the model und confirm the relevance of basic arithmetic concepts for mathematical learning at school with respective consequences for the remedial training of children with math learning difficulties and dyscalculia.}, language = {de} } @article{PrzybyllaRomeike2018, author = {Przybylla, Mareen and Romeike, Ralf}, title = {Empowering learners with tools in CS education}, series = {it - Information Technology}, volume = {60}, journal = {it - Information Technology}, number = {2}, publisher = {De Gruyter}, address = {Berlin}, issn = {1611-2776}, doi = {10.1515/itit-2017-0032}, pages = {91 -- 101}, year = {2018}, abstract = {In computer science, computer systems are both, objects of investigation and tools that enable creative learning and design. Tools for learning have a long tradition in computer science education. Already in the late 1960s, Papert developed a concept which had an immense impact on the development of informal education in the following years: his theory of constructionism understands learning as a creative process of knowledge construction that is most effective when learners create something purposeful that they can try out, show around, discuss, analyse and receive praise for. By now, there are numerous learning and programming environments that are based on the constructionist ideas. Modern tools offer opportunities for students to learn in motivating ways and gain impressive results in programming games, animations, implementing 3D models or developing interactive objects. This article gives an overview of computer science education research related to tools and media to be used in educational settings. We analyse different types of tools with a special focus on the categorization and development of tools for student adequate physical computing activities in the classroom. Research around the development and evaluation of tools and learning resources in the domain of physical computing is illustrated with the example of "My Interactive Garden", a constructionist learning and programming environment. It is explained how the results from empirical studies are integrated in the continuous development of the learning material.}, language = {en} }