@article{RomanLopesFrancoSanmartin2015, author = {Roman-Lopes, A. and Franco, G. A. P. and Sanmartin, D.}, title = {SOAR Near-Infrared and Optical Survey of OIf* and OIf*/WN Stars in the Periphery of Galactic Massive Star Forming Regions}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-87585}, pages = {31 -- 34}, year = {2015}, abstract = {In this contribution we present some preliminary results obtained from a SOAR-Goodman optical spectroscopic survey aimed to confirm the OIf* - OIf*/WN nature of a sample of Galactic candidates that were previously confirmed as massive stars based on near-infrared spectra taken with OSIRIS at SOAR. With only a few of such stars known in the Galaxy to date, our study significantly contributes to improve the number of known Galactic O2If* stars, as well as almost doubling the number of known members of the galactic sample of the rare type OIf*/WN.}, language = {en} } @article{MarstonMauerhanMorrisetal.2015, author = {Marston, A. P. and Mauerhan, J. and Morris, P. W. and Van Dyk, S.}, title = {Finding Wolf-Rayet Stars in the Milky Way}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-87577}, pages = {27 -- 30}, year = {2015}, abstract = {The total population of Wolf-Rayet (WR) stars in the Galaxy is predicted by models to be as many as ~6000 stars, and yet the number of catalogued WR stars as a result of optical surveys was far lower than this (~200) at the turn of this century. When beginning our WR searches using infrared techniques it was not clear whether WR number predictions were too optimistic or whether there was more hidden behind interstellar and circumstellar extinction. During the last decade we pioneered a technique of exploiting the near- and mid-infrared continuum colours for individual point sources provided by large-format surveys of the Galaxy, including 2MASS and Spitzer/GLIMPSE, to pierce through the dust and reveal newly discovered WR stars throughout the Galactic Plane. The key item to the colour discrimination is via the characteristic infrared spectral index produced by the strong winds of the WR stars, combined with dust extinction, which place WR stars in a relatively depopulated area of infrared colour-colour diagrams. The use of the Spitzer/GLIMPSE 8µm and, more recently, WISE 22µm fluxes together with cross-referencing with X-ray measurements in selected Galactic regions have enabled improved candidate lists that increased our confirmation success rate, achieved via follow-up infrared and optical spectroscopy. To date a total of 102 new WR stars have been found with many more candidates still available for follow-up. This constitutes an addition of ~16\% to the current inventory of 642 Galactic WR stars. In this talk we review our methods and provide some new results and a preliminary review of their stellar and interstellar medium environments. We provide a roadmap for the future of this search, including statistical modeling, and what we can add to star formation and high mass star evolution studies.}, language = {en} } @article{Moffat2015, author = {Moffat, Anthony F. J.}, title = {General overview of Wolf-Rayet stars}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-87552}, pages = {13 -- 18}, year = {2015}, abstract = {Although we all use the name Wolf-Rayet to refer to specific groups of stars, "Wolf-Rayet" per se is really an astrophysical phenomenon of fast-moving, hot plasma, normally expanding around a hot star. However, expediency demands that we follow established traditions by referring to three specific kinds of WR stars: (1) cWR, "classical" He-burning descendants of massive, O-type stars, presumably all of which pass through a WR stage; (2) WNh, the most massive and luminous hydrogen-rich main-sequence stars with strong winds; and (3) [WR], the central stars of some 15 \% of Planetary Nebulae. Wolf-Rayet stars are the epitome of relatively stable stars with the highest mass-loss rates for their kind. It behooves us to understand the what, how and why of this circumstance, along with its manyfold and fascinating consequences.}, language = {en} } @article{Crowther2015, author = {Crowther, P. A.}, title = {Wolf-Rayet content of the Milky Way}, series = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, journal = {Wolf-Rayet Stars : Proceedings of an International Workshop held in Potsdam, Germany, 1.-5. June 2015}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-87562}, pages = {21 -- 26}, year = {2015}, abstract = {An overview of the known Wolf-Rayet (WR) population of the Milky Way is presented, including a brief overview of historical catalogues and recent advances based on infrared photometric and spectroscopic observations resulting in the current census of 642 (vl.13 online catalogue). The observed distribution of WR stars is considered with respect to known star clusters, given that ≤20\% of WR stars in the disk are located in clusters. WN stars outnumber WC stars at all galactocentric radii, while early-type WC stars are strongly biased against the inner Milky Way. Finally, recent estimates of the global WR population in the Milky Way are reassessed, with 1,200±100 estimated, such that the current census may be 50\% complete. A characteristic WR lifetime of 0.25 Myr is inferred for an initial mass threshold of 25 M⊙.}, language = {en} } @article{Lundberg2015, author = {Lundberg, Karin}, title = {Networking knowledge}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XVI}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {30}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86968}, pages = {78 -- 83}, year = {2015}, abstract = {Global citizenship and diversity are well-represented concepts in today's higher education. Learning outcomes and competencies are designed to sensitize students to the many cultural backgrounds of U.S. learning institutions. Nevertheless, true globality, as represented through diverse discourses and perspectives of the world, still seems neglected in curricula and course assignments. This article explores the possibilities offered through a new shared space in education where different forms of networked knowledge and multifaceted perspectives can build a global platform of exchange in a diverse student population. The universal science concept described by Alexander von Humboldt at the beginning of the 19th Century illuminates this intertwined approach to knowledge of the world, which has the potential to positively impact contemporary curricula and course design. Von Humboldt's writings emphasize inclusion and interplay among cultures and natural phenomena. By inviting our students to be active representatives of diverse discourses, these interconnecting links will become more transparent. In turn, productive forms of knowing about the world may enrich current learning objectives and thereby reflect a true global citizenship as it evolves in a new shared space of education. Keywords: global citizenship, plurality, diverse discourses, multicultural education.}, language = {en} } @article{Buffon2015, author = {Buffon, Giuseppe}, title = {The Franciscans in Cathay}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XVI}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {30}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86920}, pages = {13 -- 28}, year = {2015}, abstract = {The study analyzes the process that leads to the elaboration of the thesis of a continuity between the Medieval Asia mission and the New World mission. This effort, undertaken by the Catholic historiography of the mission during the XIX century, is the result of the impulse provided by Alexander von Humboldt's studies about the discovery of America (Examen critique). The data about the geography of Asia collected by the missionaries-travelers working in the territory between Karakorum and Khanbalik during the XIII e XIV century reaches Christopher Colombus with the mediation of Roger Bacon, whom Humboldt himself esteems as a true cultural mediator. The conclusion of the article tries to identify reasons and modalities of the secularization of the missionary concept, i.e. the shift from the ideal of the propagation of the Christian message to a prevailing interest for cartography and topography, transformations arranged by a late medieval historiography that introduces into martyrolagia the loca toponomastica.}, language = {en} } @article{Roba2014, author = {Roba, Bill}, title = {German-Iowan strategies in celebrating the centennial of Alexander von Humboldt's birth}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {29}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84997}, pages = {179 -- 188}, year = {2014}, abstract = {The two largest cities of Eastern Iowa on the shore of the Mississippi River are Dubuque and Davenport. In each city, an elite group of German-Iowan leaders emerged by the late 1850s. Bill Roba describes and examines their strategies in celebrating the Centennial of Alexander von Humboldt's Birth.}, language = {en} } @article{BanerjeeStuekerSaalfrank2015, author = {Banerjee, Shiladitya and St{\"u}ker, Tony and Saalfrank, Peter}, title = {Vibrationally resolved optical spectra of modified diamondoids obtained from time-dependent correlation function methods}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, volume = {17}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, number = {29}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9084}, doi = {10.1039/C5CP02615F}, pages = {19656 -- 19669}, year = {2015}, abstract = {Optical properties of modified diamondoids have been studied theoretically using vibrationally resolved electronic absorption, emission and resonance Raman spectra. A time-dependent correlation function approach has been used for electronic two-state models, comprising a ground state (g) and a bright, excited state (e), the latter determined from linear-response, time-dependent density functional theory (TD-DFT). The harmonic and Condon approximations were adopted. In most cases origin shifts, frequency alteration and Duschinsky rotation in excited states were considered. For other cases where no excited state geometry optimization and normal mode analysis were possible or desired, a short-time approximation was used. The optical properties and spectra have been computed for (i) a set of recently synthesized sp2/sp3 hybrid species with C[double bond, length as m-dash]C double-bond connected saturated diamondoid subunits, (ii) functionalized (mostly by thiol or thione groups) diamondoids and (iii) urotropine and other C-substituted diamondoids. The ultimate goal is to tailor optical and electronic features of diamondoids by electronic blending, functionalization and substitution, based on a molecular-level understanding of the ongoing photophysics.}, language = {en} } @article{LaubrockKliegl2015, author = {Laubrock, Jochen and Kliegl, Reinhold}, title = {The eye-voice span during reading aloud}, series = {Frontiers in psychology}, volume = {6}, journal = {Frontiers in psychology}, number = {1432}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2015.01432}, year = {2015}, abstract = {Although eye movements during reading are modulated by cognitive processing demands, they also reflect visual sampling of the input, and possibly preparation of output for speech or the inner voice. By simultaneously recording eye movements and the voice during reading aloud, we obtained an output measure that constrains the length of time spent on cognitive processing. Here we investigate the dynamics of the eye-voice span (EVS), the distance between eye and voice. We show that the EVS is regulated immediately during fixation of a word by either increasing fixation duration or programming a regressive eye movement against the reading direction. EVS size at the beginning of a fixation was positively correlated with the likelihood of regressions and refixations. Regression probability was further increased if the EVS was still large at the end of a fixation: if adjustment of fixation duration did not sufficiently reduce the EVS during a fixation, then a regression rather than a refixation followed with high probability. We further show that the EVS can help understand cognitive influences on fixation duration during reading: in mixed model analyses, the EVS was a stronger predictor of fixation durations than either word frequency or word length. The EVS modulated the influence of several other predictors on single fixation durations (SFDs). For example, word-N frequency effects were larger with a large EVS, especially when word N-1 frequency was low. Finally, a comparison of SFDs during oral and silent reading showed that reading is governed by similar principles in both reading modes, although EVS maintenance and articulatory processing also cause some differences. In summary, the EVS is regulated by adjusting fixation duration and/or by programming a regressive eye movement when the EVS gets too large. Overall, the EVS appears to be directly related to updating of the working memory buffer during reading.}, language = {en} } @article{LamannaKirschbaumWauricketal.2015, author = {Lamanna, Francesco and Kirschbaum, Frank and Waurick, Isabelle and Dieterich, Christoph and Tiedemann, Ralph}, title = {Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae)}, series = {BMC Genomics}, volume = {16}, journal = {BMC Genomics}, number = {668}, publisher = {Biomed Central}, address = {London}, issn = {1471-2164}, doi = {10.1186/s12864-015-1858-9}, year = {2015}, abstract = {Background African weakly-electric fishes of the family Mormyridae are able to produce and perceive weak electric signals (typically less than one volt in amplitude) owing to the presence of a specialized, muscle-derived electric organ (EO) in their tail region. Such electric signals, also known as Electric Organ Discharges (EODs), are used for objects/prey localization, for the identification of conspecifics, and in social and reproductive behaviour. This feature might have promoted the adaptive radiation of this family by acting as an effective pre-zygotic isolation mechanism. Despite the physiological and evolutionary importance of this trait, the investigation of the genetic basis of its function and modification has so far remained limited. In this study, we aim at: i) identifying constitutive differences in terms of gene expression between electric organ and skeletal muscle (SM) in two mormyrid species of the genus Campylomormyrus: C. compressirostris and C. tshokwe, and ii) exploring cross-specific patterns of gene expression within the two tissues among C. compressirostris, C. tshokwe, and the outgroup species Gnathonemus petersii. Results Twelve paired-end (100 bp) strand-specific RNA-seq Illumina libraries were sequenced, producing circa 330 M quality-filtered short read pairs. The obtained reads were assembled de novo into four reference transcriptomes. In silico cross-tissue DE-analysis allowed us to identify 271 shared differentially expressed genes between EO and SM in C. compressirostris and C.tshokwe. Many of these genes correspond to myogenic factors, ion channels and pumps, and genes involved in several metabolic pathways. Cross-species analysis has revealed that the electric organ transcriptome is more variable in terms of gene expression levels across species than the skeletal muscle transcriptome. Conclusions The data obtained indicate that: i) the loss of contractile activity and the decoupling of the excitation-contraction processes are reflected by the down-regulation of the corresponding genes in the electric organ's transcriptome; ii) the metabolic activity of the EO might be specialized towards the production and turn-over of membrane structures; iii) several ion channels are highly expressed in the EO in order to increase excitability; iv) several myogenic factors might be down-regulated by transcription repressors in the EO.}, language = {en} } @article{PulkkinenMetzler2015, author = {Pulkkinen, Otto and Metzler, Ralf}, title = {Variance-corrected Michaelis-Menten equation predicts transient rates of single-enzyme reactions and response times in bacterial gene-regulation}, series = {Scientific reports}, journal = {Scientific reports}, number = {5}, publisher = {Nature Publishing Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/srep17820}, year = {2015}, abstract = {Many chemical reactions in biological cells occur at very low concentrations of constituent molecules. Thus, transcriptional gene-regulation is often controlled by poorly expressed transcription-factors, such as E.coli lac repressor with few tens of copies. Here we study the effects of inherent concentration fluctuations of substrate-molecules on the seminal Michaelis-Menten scheme of biochemical reactions. We present a universal correction to the Michaelis-Menten equation for the reaction-rates. The relevance and validity of this correction for enzymatic reactions and intracellular gene-regulation is demonstrated. Our analytical theory and simulation results confirm that the proposed variance-corrected Michaelis-Menten equation predicts the rate of reactions with remarkable accuracy even in the presence of large non-equilibrium concentration fluctuations. The major advantage of our approach is that it involves only the mean and variance of the substrate-molecule concentration. Our theory is therefore accessible to experiments and not specific to the exact source of the concentration fluctuations.}, language = {en} } @article{GolleMuehlbauerWicketal.2015, author = {Golle, Kathleen and M{\"u}hlbauer, Thomas and Wick, Ditmar and Granacher, Urs}, title = {Physical Fitness Percentiles of German Children Aged 9-12 Years}, series = {PLoS ONE}, volume = {10}, journal = {PLoS ONE}, number = {11}, publisher = {Public Library of Science}, address = {Lawrence, Kan.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0142393}, year = {2015}, abstract = {Background Generating percentile values is helpful for the identification of children with specific fitness characteristics (i.e., low or high fitness level) to set appropriate fitness goals (i.e., fitness/health promotion and/or long-term youth athlete development). Thus, the aim of this longitudinal study was to assess physical fitness development in healthy children aged 9-12 years and to compute sex- and age-specific percentile values. Methods Two-hundred and forty children (88 girls, 152 boys) participated in this study and were tested for their physical fitness. Physical fitness was assessed using the 50-m sprint test (i.e., speed), the 1-kg ball push test, the triple hop test (i.e., upper- and lower- extremity muscular power), the stand-and-reach test (i.e., flexibility), the star run test (i.e., agility), and the 9-min run test (i.e., endurance). Age- and sex-specific percentile values (i.e., P10 to P90) were generated using the Lambda, Mu, and Sigma method. Adjusted (for change in body weight, height, and baseline performance) age- and sex-differences as well as the interactions thereof were expressed by calculating effect sizes (Cohen's d). Results Significant main effects of Age were detected for all physical fitness tests (d = 0.40-1.34), whereas significant main effects of Sex were found for upper-extremity muscular power (d = 0.55), flexibility (d = 0.81), agility (d = 0.44), and endurance (d = 0.32) only. Further, significant Sex by Age interactions were observed for upper-extremity muscular power (d = 0.36), flexibility (d = 0.61), and agility (d = 0.27) in favor of girls. Both, linear and curvilinear shaped curves were found for percentile values across the fitness tests. Accelerated (curvilinear) improvements were observed for upper-extremity muscular power (boys: 10-11 yrs; girls: 9-11 yrs), agility (boys: 9-10 yrs; girls: 9-11 yrs), and endurance (boys: 9-10 yrs; girls: 9-10 yrs). Tabulated percentiles for the 9-min run test indicated that running distances between 1,407-1,507 m, 1,479-1,597 m, 1,423-1,654 m, and 1,433-1,666 m in 9- to 12-year-old boys and 1,262-1,362 m, 1,329-1,434 m, 1,392-1,501 m, and 1,415-1,526 m in 9- to 12-year-old girls correspond to a "medium" fitness level (i.e., P40 to P60) in this population. Conclusions The observed differences in physical fitness development between boys and girls illustrate that age- and sex-specific maturational processes might have an impact on the fitness status of healthy children. Our statistical analyses revealed linear (e.g., lower-extremity muscular power) and curvilinear (e.g., agility) models of fitness improvement with age which is indicative of timed and capacity-specific fitness development pattern during childhood. Lastly, the provided age- and sex-specific percentile values can be used by coaches for talent identification and by teachers for rating/grading of children's motor performance.}, language = {en} } @article{RoderHille2015, author = {Roder, Phillip and Hille, Carsten}, title = {A Multifunctional Frontloading Approach for Repeated Recycling of a Pressure-Controlled AFM Micropipette}, series = {PLoS ONE}, volume = {10}, journal = {PLoS ONE}, number = {12}, publisher = {Public Library of Science}, address = {Lawrence, Kan.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0144157}, year = {2015}, abstract = {Fluid force microscopy combines the positional accuracy and force sensitivity of an atomic force microscope (AFM) with nanofluidics via a microchanneled cantilever. However, adequate loading and cleaning procedures for such AFM micropipettes are required for various application situations. Here, a new frontloading procedure is described for an AFM micropipette functioning as a force- and pressure-controlled microscale liquid dispenser. This frontloading procedure seems especially attractive when using target substances featuring high costs or low available amounts. Here, the AFM micropipette could be filled from the tip side with liquid from a previously applied droplet with a volume of only a few μL using a short low-pressure pulse. The liquid-loaded AFM micropipettes could be then applied for experiments in air or liquid environments. AFM micropipette frontloading was evaluated with the well-known organic fluorescent dye rhodamine 6G and the AlexaFluor647-labeled antibody goat anti-rat IgG as an example of a larger biological compound. After micropipette usage, specific cleaning procedures were tested. Furthermore, a storage method is described, at which the AFM micropipettes could be stored for a few hours up to several days without drying out or clogging of the microchannel. In summary, the rapid, versatile and cost-efficient frontloading and cleaning procedure for the repeated usage of a single AFM micropipette is beneficial for various application situations from specific surface modifications through to local manipulation of living cells, and provides a simplified and faster handling for already known experiments with fluid force microscopy.}, language = {en} } @article{WarschburgerCalvanoRichteretal.2015, author = {Warschburger, Petra and Calvano, Claudia and Richter, Eike M. and Engbert, Ralf}, title = {Analysis of Attentional Bias towards Attractive and Unattractive Body Regions among Overweight Males and Females}, series = {PLoS one}, journal = {PLoS one}, number = {10}, publisher = {Public Library of Science}, address = {Lawrence, Kan.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0140813}, pages = {17}, year = {2015}, abstract = {Background Body image distortion is highly prevalent among overweight individuals. Whilst there is evidence that body-dissatisfied women and those suffering from disordered eating show a negative attentional bias towards their own unattractive body parts and others' attractive body parts, little is known about visual attention patterns in the area of obesity and with respect to males. Since eating disorders and obesity share common features in terms of distorted body image and body dissatisfaction, the aim of this study was to examine whether overweight men and women show a similar attentional bias. Methods/Design We analyzed eye movements in 30 overweight individuals (18 females) and 28 normalweight individuals (16 females) with respect to the participants' own pictures as well as gender- and BMI-matched control pictures (front and back view). Additionally, we assessed body image and disordered eating using validated questionnaires. Discussion The overweight sample rated their own body as less attractive and showed a more disturbed body image. Contrary to our assumptions, they focused significantly longer on attractive compared to unattractive regions of both their own and the control body. For one's own body, this was more pronounced for women. A higher weight status and more frequent body checking predicted attentional bias towards attractive body parts. We found that overweight adults exhibit an unexpected and stable pattern of selective attention, with a distinctive focus on their own attractive body regions despite higher levels of body dissatisfaction. This positive attentional bias may either be an indicator of a more pronounced pattern of attentional avoidance or a self-enhancing strategy. Further research is warranted to clarify these results.}, language = {en} } @article{DiewaldWischer2013, author = {Diewald, Gariele and Wischer, Ilse}, title = {Markers of futurity in old high german and old english}, series = {Comparative Studies in Early Germanic Languages}, journal = {Comparative Studies in Early Germanic Languages}, editor = {Diewald, Gabriele and Kahlas-Karkka, Leena and Wischer, Ilse}, publisher = {Benjamins Publishing}, address = {Amsterdam}, isbn = {978-90-272-7145-7}, pages = {195 -- 215}, year = {2013}, language = {en} } @article{Rosenzweig2015, author = {Rosenzweig, Claudia}, title = {When Jesus Spoke Yiddish}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, volume = {21}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-331-2}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-85881}, pages = {199 -- 214}, year = {2015}, abstract = {Im folgenden Artikel sollen exemplarische Passagen eines der jiddischen "Toldot- Yeshu"-Manuskripte diskutiert werden, das bis zum gegenw{\"a}rtigen Zeitpunkt noch nicht wissenschaftlich untersucht wurde: Die Handschrift mit der Signatur MS. G{\"u}nzburg 1730 wird in der Russischen Staatsbibliothek in Moskau aufbewahrt und in das 17. Jahrhundert datiert. Das Manuskript ist in die sogenannte ‚Herodes Tradition' der "Toledot Yeshu" einzuordnen. Demzufolge ist die vorliegende jiddische Handschrift MS. G{\"u}nzburg 1730 mit der hebr{\"a}isch gedruckten Version verwandt, die zusammen mit einer lateinischen {\"U}bersetzung von dem Schweizer Pastoren und Theologen Johann Jacob Uldrich (Huldricus, 1683-1731) im Jahre 1705 in Leiden unter dem Titel "Historia Jeschuae Nazareni" publiziert wurde. Obschon die genaue Datierung der jiddischen Handschrift nicht m{\"o}glich ist, erlauben exemplarische Vergleiche zwischen den hebr{\"a}ischen und den jiddischen Texten dennoch spezifische Merkmale der jiddischen Version herauszustellen, und Fragen {\"u}ber die {\"U}bermittlung und der Rezeption dieses anspruchsvollen und interessanten Textes aufzuwerfen.}, language = {en} } @article{Rajner2015, author = {Rajner, Mirjam}, title = {Zinovii Tolkatchev's „Jesus in Majdanek"}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, volume = {21}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-331-2}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-85794}, pages = {59 -- 85}, year = {2015}, abstract = {Zinovii Shenderovich Tolkatchev (1903-1977), ein sowjetischer K{\"u}nstler j{\"u}discher Herkunft, kreierte 1945 eine eindrucksvolle Serie von f{\"u}nf Bildern mit dem Titel "Jesus in Majdanek". Die Serie war der H{\"o}hepunkt von Tolkatchevs intensiver Auseinandersetzung mit den Erfahrungen, die er als Soldat der Roten Armee, w{\"a}hrend der Befreiung der Konzentrationslager Majdanek und Auschwitz gemacht hatte. Schockiert von dem dort Gesehenen, zeigt er Jesus als Lagerinsassen, der eine gestreifte Uniform tr{\"a}gt, die alle nur m{\"o}glichen Diffamierungszeichen aufweist - den j{\"u}dischen gelben Stern, das rote Dreieck politischer Gefangener und die individuelle Gefangenennummer. Die numerische T{\"a}towierung am Unterarm ist auch zu sehen. Die verschiedenen Abschnitte des Lagerlebens werden als die der traditionellen Passion Christi dargestellt. W{\"a}hrend der K{\"u}nstler die verschiedenen Phasen des Leidens Jesu kanonisch portraitiert, basiert sein k{\"u}nstlerisches Schaffen auf den der bekannten Malereien der europ{\"a}ischen Renaissance. Der Artikel platziert Tolkatchevs Bilderserie in einem breiteren kulturellen und visuellen Kontext, da er sowohl die Entwicklung des ‚historischen Jesu' typisch f{\"u}r das Denkbild des Europas des 19. Jahrhunderts und der Kunst des Russischem Realismus als auch den Einfluss der deutschen Avantgarde, untersucht. Dadurch bietet sich ein tiefsinnigeres Verstehen von Tolkatchevs Arbeit und ihrer universellen Botschaft.}, language = {en} } @article{DalBo2015, author = {Dal Bo, Federico}, title = {The Theological and Cultural Challenge of Messianic Jews}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, volume = {21}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien [21 (2015)] = Jesus in den J{\"u}dischen Kulturen des 19. und 20. Jahrhunderts}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-331-2}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-85762}, pages = {33 -- 58}, year = {2015}, abstract = {Messianische Juden sind Juden, die den messianischen Charakter Jesus sowohl wie den in traditionelles Judentum {\"u}bermittelten Kult synkretistisch annehmen. Der vorliegende Beitrag untersucht die Entstehung dieser synkretistischen und im heutigen Israel marginalen Bewegung und behauptet, dass sie eine radikale Entwicklung in der zweitausendj{\"a}hrigen Geschichte der j{\"u}disch-christlichen Beziehungen darstellt. Dieser Beitrag bietet eine allgemeine Einf{\"u}hrung in den Begriff der j{\"u}disch-christlichen Identit{\"a}t, eine kurze Geschichte von der ersten Gruppe der messianischen Juden im Land Israels, einen {\"U}berblick {\"u}ber den religi{\"o}sen Synkretismus der messianischen Juden und ihren den kulturellen Einfluss auf den modernen Israel und, schließlich, die Implikation, dass das messianische Judentum f{\"u}r ein neues Paradigma innerhalb der verschiedenen Hauptstr{\"o}mungen des Judentums gehalten werden sollte.}, language = {en} } @article{BodrovaChechkinCherstvyetal.2015, author = {Bodrova, Anna and Chechkin, Aleksei V. and Cherstvy, Andrey G. and Metzler, Ralf}, title = {Quantifying non-ergodic dynamics of force-free granular gases}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, number = {17}, issn = {1463-9084}, doi = {10.1039/C5CP02824H}, pages = {21791 -- 21798}, year = {2015}, abstract = {Brownianmotion is ergodic in the Boltzmann-Khinchin sense that long time averages of physical observables such as the mean squared displacement provide the same information as the corresponding ensemble average, even at out-of-equilibrium conditions. This property is the fundamental prerequisite for single particle tracking and its analysis in simple liquids. We study analytically and by event-driven molecular dynamics simulations the dynamics of force-free cooling granular gases and reveal a violation of ergodicity in this Boltzmann- Khinchin sense as well as distinct ageing of the system. Such granular gases comprise materials such as dilute gases of stones, sand, various types of powders, or large molecules, and their mixtures are ubiquitous in Nature and technology, in particular in Space. We treat—depending on the physical-chemical properties of the inter-particle interaction upon their pair collisions—both a constant and a velocity-dependent (viscoelastic) restitution coefficient e. Moreover we compare the granular gas dynamics with an effective single particle stochastic model based on an underdamped Langevin equation with time dependent diffusivity. We find that both models share the same behaviour of the ensemble mean squared displacement (MSD) and the velocity correlations in the limit of weak dissipation. Qualitatively, the reported non-ergodic behaviour is generic for granular gases with any realistic dependence of e on the impact velocity of particles.}, language = {en} } @article{MaiBoyeYuanetal.2015, author = {Mai, Tobias and Boye, Susanne and Yuan, Jiayin and V{\"o}lkel, Antje and Gr{\"a}wert, Marlies and G{\"u}nter, Christina and Lederer, Albena and Taubert, Andreas}, title = {Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization}, series = {RSC Advances : an international journal to further the chemical sciences}, journal = {RSC Advances : an international journal to further the chemical sciences}, number = {5}, publisher = {RSC Publishing}, address = {London}, issn = {2046-2069}, doi = {10.1039/c5ra20035k}, pages = {103494 -- 103505}, year = {2015}, abstract = {The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine)s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium)ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 106 g mol-1. All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal Mn = 100 000 g mol-1). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.}, language = {en} } @article{MardoukhiJeonMetzler2015, author = {Mardoukhi, Yousof and Jeon, Jae-Hyung and Metzler, Ralf}, title = {Geometry controlled anomalous diffusion in random fractal geometries}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, number = {17}, publisher = {Wiley-VCH Verl.}, address = {Weinheim}, issn = {1439-7641}, doi = {10.1039/c5cp03548a}, pages = {30134 -- 30147}, year = {2015}, abstract = {We investigate the ergodic properties of a random walker performing (anomalous) diffusion on a random fractal geometry. Extensive Monte Carlo simulations of the motion of tracer particles on an ensemble of realisations of percolation clusters are performed for a wide range of percolation densities. Single trajectories of the tracer motion are analysed to quantify the time averaged mean squared displacement (MSD) and to compare this with the ensemble averaged MSD of the particle motion. Other complementary physical observables associated with ergodicity are studied, as well. It turns out that the time averaged MSD of individual realisations exhibits non-vanishing fluctuations even in the limit of very long observation times as the percolation density approaches the critical value. This apparent non-ergodic behaviour concurs with the ergodic behaviour on the ensemble averaged level. We demonstrate how the non-vanishing fluctuations in single particle trajectories are analytically expressed in terms of the fractal dimension and the cluster size distribution of the random geometry, thus being of purely geometrical origin. Moreover, we reveal that the convergence scaling law to ergodicity, which is known to be inversely proportional to the observation time T for ergodic diffusion processes, follows a power-law BT� h with h o 1 due to the fractal structure of the accessible space. These results provide useful measures for differentiating the subdiffusion on random fractals from an otherwise closely related process, namely, fractional Brownian motion. Implications of our results on the analysis of single particle tracking experiments are provided.}, language = {en} } @article{KuschpelLiuSchadetal.2015, author = {Kuschpel, Maxim S. and Liu, Shuyan and Schad, Daniel and Heinzel, Stephan and Heinz, Andreas and Rapp, Michael A.}, title = {Differential effects of wakeful rest, music and video game playing on working memory performance in the n-back task}, series = {Frontiers in psychology}, journal = {Frontiers in psychology}, number = {6}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2015.01683}, year = {2015}, abstract = {The interruption of learning processes by breaks filled with diverse activities is common in everyday life. We investigated the effects of active computer gaming and passive relaxation (rest and music) breaks on working memory performance. Young adults were exposed to breaks involving (i) eyes-open resting, (ii) listening to music and (iii) playing the video game "Angry Birds" before performing the n-back working memory task. Based on linear mixed-effects modeling, we found that playing the "Angry Birds" video game during a short learning break led to a decline in task performance over the course of the task as compared to eyes-open resting and listening to music, although overall task performance was not impaired. This effect was associated with high levels of daily mind wandering and low self-reported ability to concentrate. These findings indicate that video games can negatively affect working memory performance over time when played in between learning tasks. We suggest further investigation of these effects because of their relevance to everyday activity.}, language = {en} } @article{Werner2015, author = {Werner, Anja}, title = {Alexander von Humboldt's footnotes}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {28}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84076}, pages = {59 -- 67}, year = {2015}, abstract = {Alexander von Humboldts Fußnoten waren ihrer Zeit weit voraus, obwohl sie kaum den heutigen akademischen Standards entsprechen. Dieser Artikel untersucht die Fußnoten in Humboldts Essai politique sur l'{\^i}le de Cuba (1826). Zwar ist es nicht immer leicht, die manchmal recht geheimnisvollen Verweise zu entschl{\"u}sseln, dennoch lohnt sich der Versuch: Humboldts Fußnoten geben nicht nur Auskunft {\"u}ber seine umfassenden Netzwerke des Wissens. Sie verweisen auch auf Auseinandersetzungen verschiedener Gelehrter {\"u}ber Humboldts Schriften. Schließlich beinhalten sie Humboldts Reaktionen auf solche Auseinandersetzungen. Eine Untersuchung von Humboldts Fußnoten erlaubt es folglich dem Leser, mehr {\"u}ber Humboldt den Wissenschaftler aber auch Humboldt den Mensch zu erfahren.}, language = {en} } @article{EstevamOFernandes2015, author = {Estevam O. Fernandes, Luiz}, title = {Political essay on the kingdom of New Spain}, series = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, volume = {XV}, journal = {HiN : Alexander von Humboldt im Netz ; International Review for Humboldtian Studies}, number = {28}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1617-5239}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-84047}, pages = {24 -- 33}, year = {2015}, abstract = {In this paper we discuss how Alexander von Humboldt conceived a past to New Spain in his Political Essay on New Spain (1811) and how this text was, in turn, appropriated by the Mexican historiography during the 19th century. In order to do so, we analyze how the Prussian drew from American sources, particularly from the text of the Jesuit Francisco Javier Clavijero, written shortly before. We also study Humboldt's conceptions of text and of history, highlighting the place of the indigenous in the composition of his reasoning. Finally, we give examples of how the Mexican nationalist historiography read and reinterpreted the Political Essay.}, language = {en} } @article{SbragagliaLamannaMatetal.2015, author = {Sbragaglia, Valerio and Lamanna, Francesco and Mat, Audrey M. and Rotllant, Guiomar and Joly, Silvia and Ketmaier, Valerio and de la Iglesia, Horacio O. and Aguzzi, Jacopo}, title = {Identification, Characterization, and Diel Pattern of Expression of Canonical Clock Genes in Nephrops norvegicus (Crustacea: Decapoda) Eyestalk}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {11}, publisher = {Public Library of Science}, address = {Lawrence}, issn = {1932-6203}, doi = {10.1371/journal.pone.0141893}, year = {2015}, abstract = {The Norway lobster, Nephrops norvegicus, is a burrowing decapod with a rhythmic burrow emergence (24 h) governed by the circadian system. It is an important resource for European fisheries and its behavior deeply affects its availability. The current knowledge of Nephrops circadian biology is phenomenological as it is currently the case for almost all crustaceans. In attempt to elucidate the putative molecular mechanisms underlying circadian gene regulation in Nephrops, we used a transcriptomics approach on cDNA extracted from the eyestalk, a structure playing a crucial role in controlling behavior of decapods. We studied 14 male lobsters under 12-12 light-darkness blue light cycle. We used the Hiseq 2000 Illumina platform to sequence two eyestalk libraries (under light and darkness conditions) obtaining about 90 millions 100-bp paired-end reads. Trinity was used for the de novo reconstruction of transcriptomes; the size at which half of all assembled bases reside in contigs (N50) was equal to 1796 (light) and 2055 (darkness). We found a list of candidate clock genes and focused our attention on canonical ones: timeless, period, clock and bmal1. The cloning of assembled fragments validated Trinity outputs. The putative Nephrops clock genes showed high levels of identity (blastx on NCBI) with known crustacean clock gene homologs such as Eurydice pulchra (period: 47\%, timeless: 59\%, bmal1: 79\%) and Macrobrachium rosenbergii (clock: 100\%). We also found a vertebrate-like cryptochrome 2. RT-qPCR showed that only timeless had a robust diel pattern of expression. Our data are in accordance with the current knowledge of the crustacean circadian clock, reinforcing the idea that the molecular clockwork of this group shows some differences with the established model in Drosophila melanogaster.}, language = {en} } @article{VormoorLawrenceHeistermannetal.2015, author = {Vormoor, Klaus Josef and Lawrence, D. and Heistermann, Maik and Bronstert, Axel}, title = {Climate change impacts on the seasonality and generation processes of floods}, series = {Hydrology and earth system sciences : HESS}, volume = {19}, journal = {Hydrology and earth system sciences : HESS}, number = {2}, publisher = {Copernicus Publications}, address = {G{\"o}ttingen}, issn = {1027-5606}, doi = {10.5194/hess-19-913-2015}, pages = {913 -- 931}, year = {2015}, abstract = {Climate change is likely to impact the seasonality and generation processes of floods in the Nordic countries, which has direct implications for flood risk assessment, design flood estimation, and hydropower production management. Using a multi-model/multi-parameter approach to simulate daily discharge for a reference (1961-1990) and a future (2071-2099) period, we analysed the projected changes in flood seasonality and generation processes in six catchments with mixed snowmelt/rainfall regimes under the current climate in Norway. The multi-model/multi-parameter ensemble consists of (i) eight combinations of global and regional climate models, (ii) two methods for adjusting the climate model output to the catchment scale, and (iii) one conceptual hydrological model with 25 calibrated parameter sets. Results indicate that autumn/winter events become more frequent in all catchments considered, which leads to an intensification of the current autumn/winter flood regime for the coastal catchments, a reduction of the dominance of spring/summer flood regimes in a high-mountain catchment, and a possible systematic shift in the current flood regimes from spring/summer to autumn/winter in the two catchments located in northern and south-eastern Norway. The changes in flood regimes result from increasing event magnitudes or frequencies, or a combination of both during autumn and winter. Changes towards more dominant autumn/winter events correspond to an increasing relevance of rainfall as a flood generating process (FGP) which is most pronounced in those catchments with the largest shifts in flood seasonality. Here, rainfall replaces snowmelt as the dominant FGP primarily due to increasing temperature.We further analysed the ensemble components in contributing to overall uncertainty in the projected changes and found that the climate projections and the methods for downscaling or bias correction tend to be the largest contributors. The relative role of hydrological parameter uncertainty, however, is highest for those catchments showing the largest changes in flood seasonality, which confirms the lack of robustness in hydrological model parameterization for simulations under transient hydrometeorological conditions.}, language = {en} } @article{WiemannMahlberg2014, author = {Wiemann, Dirk and Mahlberg, Gaby}, title = {Introduction : Perspectives on English revolutionary republicanism}, series = {Perspectives on English revolutionary republicanism}, journal = {Perspectives on English revolutionary republicanism}, editor = {Wiemann, Dirk and Mahlberg, Gaby}, publisher = {Ashgate}, address = {Farnham}, pages = {1 -- 12}, year = {2014}, language = {en} } @article{Valle2015, author = {Valle, Daniel}, title = {Modality in Kakataibo}, series = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, journal = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-4708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83784}, pages = {111 -- 137}, year = {2015}, abstract = {This paper explores the semantic space of modality in Kakataibo (Panoan). It is found that Kakataibo makes a distinction in the modal space based on the modality type. Circumstantial modality is encoded by a construction while the epistemic space is conveyed by the second position enclitics =dapi 'inferential', =id 'second-hand information' and =kuni 'contrastive assertion'. However, none of these strategies to encode modality restricts the quantificational force, leaving it underspecified. These facts are consistent with the predictions of current typologies of modal systems.}, language = {en} } @article{PfeilGenzelKuegler2015, author = {Pfeil, Simone and Genzel, Susanne and K{\"u}gler, Frank}, title = {Empirical investigation of focus and exhaustivity in Akan}, series = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, journal = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-4708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83774}, pages = {87 -- 109}, year = {2015}, abstract = {It has been observed for many African languages that focussed subjects have to appear outside of their syntactic base position, as opposed to focussed objects, which can remain in-situ. This is known as subjectobject asymmetry of focus marking, which Fiedler et al. (2010) claim to hold also for Akan. Genzel (2013), on the other hand, argues that Akan does not exhibit a subject-object focus asymmetry. A questionnaire study and a production experiment were carried out to investigate whether focussed subjects may indeed be realized in-situ in Akan. The results suggest that (i) focussed subjects do not have to be obligatorily realized ex-situ, and that (ii) the syntactic preference for the realization of a focussed subject highly depends on exhaustivity.}, language = {en} } @article{Klose2015, author = {Klose, Claudius}, title = {Sentence Type and Association with Focus in Aymara}, series = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, journal = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-4708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83768}, pages = {63 -- 86}, year = {2015}, abstract = {Sentence type marking is realized by two suffixes in Aymara, one marks declaratives and the other polar sentences (polar questions and negated sentences) by picking out one or two propositions, respectively. A third suffix, initially associated with wh-questions, turns out to be a (scalar) additive and unrelated to sentence type. The sentence-type-related suffixes associate with focus and the additive can associate with focus by attaching to the focused constituent.}, language = {en} } @article{Fominyam2015, author = {Fominyam, Henry Z.}, title = {The Syntax of Focus and Interrogation in Awing}, series = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, journal = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-4708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83755}, pages = {29 -- 62}, year = {2015}, abstract = {According to Aikhenvald (2007:5), descriptive linguistics or linguistic fieldwork "ideally involves observing the language as it is used, becoming a member of the community, and often being adopted into the kinship system". Descriptive linguistics therefore differs from theoretical linguistics in that while the former seeks to describe natural languages as they are used, the latter, other than describing, attempts to give explanations on how or why language phenomena behave in certain ways. Thus, I will abstract away from any preconceived ideas on how sentences ought to be in Awing and take the linguist/reader through focus and interrogative constructions to get a feeling of how the Awing people interact verbally.}, language = {en} } @article{AkuokoDuah2015, author = {Akuoko Duah, Reginald}, title = {Exhaustive Focus Marking in Akan}, series = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, journal = {Interdisciplinary studies on information structure : ISIS ; working papers of the SFB 632}, number = {19}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-4708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83748}, pages = {1 -- 28}, year = {2015}, abstract = {This paper reopens the discussion on focus marking in Akan (Kwa, Niger-Congo) by examining the semantics of the so-called focus marker in the language. It is shown that the so-called focus marker expresses exhaustivity when it occurs in a sentence with narrow focus. The study employs four standard tests for exhaustivity proposed in the literature to examine the semantics of Akan focus constructions (Szabolsci 1981, 1994; {\´E}. Kiss 1998; Hartmann and Zimmermann 2007). It is shown that although a focused entity with the so-called focus marker nà is interpreted to mean 'only X and nothing/nobody else,' this meaning appears to be pragmatic.}, language = {en} } @article{DelgadoKloos2015, author = {Delgado Kloos, Carlos}, title = {What about the Competencies of Educators in the New Era of Digital Education?}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83015}, pages = {435 -- 438}, year = {2015}, abstract = {A lot has been published about the competencies needed by students in the 21st century (Ravenscroft et al., 2012). However, equally important are the competencies needed by educators in the new era of digital education. We review the key competencies for educators in light of the new methods of teaching and learning proposed by Massive Open Online Courses (MOOCs) and their on-campus counterparts, Small Private Online Courses (SPOCs).}, language = {en} } @article{Micheuz2015, author = {Micheuz, Peter}, title = {Discussing Educational Standards for Digital Competence and/or Informatics Education at Lower Secondary Level}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-83008}, pages = {425 -- 431}, year = {2015}, abstract = {Participants of this workshop will be confronted exemplarily with a considerable inconsistency of global Informatics education at lower secondary level. More importantly, they are invited to contribute actively on this issue in form of short case studies of their countries. Until now, very few countries have been successful in implementing Informatics or Computing at primary and lower secondary level. The spectrum from digital literacy to informatics, particularly as a discipline in its own right, has not really achieved a breakthrough and seems to be underrepresented for these age groups. The goal of this workshop is not only to discuss the anamnesis and diagnosis of this fragmented field, but also to discuss and suggest viable forms of therapy in form of setting educational standards. Making visible good practices in some countries and comparing successful approaches are rewarding tasks for this workshop. Discussing and defining common educational standards on a transcontinental level for the age group of 14 to 15 years old students in a readable, assessable and acceptable form should keep the participants of this workshop active beyond the limited time at the workshop.}, language = {en} } @article{LaiDavisEickelmannetal.2015, author = {Lai, Kwok-Wing and Davis, Niki and Eickelmann, Birgit and Erstad, Ola and Fisser, Petra and Gibson, David and Khaddage, Ferial and Knezek, Gerald and Webb, Mary}, title = {Tackling Educational Challenges in a Digitally Networked World}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82997}, pages = {415 -- 423}, year = {2015}, language = {en} } @article{DiethelmSyrbe2015, author = {Diethelm, Ira and Syrbe, J{\"o}rn}, title = {Let's talk about CS!}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82983}, pages = {411 -- 414}, year = {2015}, abstract = {To communicate about a science is the most important key competence in education for any science. Without communication we cannot teach, so teachers should reflect about the language they use in class properly. But the language students and teachers use to communicate about their CS courses is very heterogeneous, inconsistent and deeply influenced by tool names. There is a big lack of research and discussion in CS education regarding the terminology and the role of concepts and tools in our science. We don't have a consistent set of terminology that we agree on to be helpful for learning our science. This makes it nearly impossible to do research on CS competencies as long as we have not agreed on the names we use to describe these. This workshop intends to provide room to fill with discussion and first ideas for future research in this field.}, language = {en} } @article{WegnerZenderLucke2015, author = {Wegner, Christian and Zender, Raphael and Lucke, Ulrike}, title = {ProtoSense}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82970}, pages = {405 -- 407}, year = {2015}, language = {en} } @article{Schiller2015, author = {Schiller, Thomas}, title = {Teaching Information Security (as Part of Key Competencies)}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82960}, pages = {401 -- 404}, year = {2015}, abstract = {The poster and abstract describe the importance of teaching information security in school. After a short description of information security and important aspects, I will show, how information security fits into different guidelines or models for computer science educations and that it is therefore on of the key competencies. Afterwards I will present you a rough insight of teaching information security in Austria.}, language = {en} } @article{Opel2015, author = {Opel, Simone}, title = {On the Way to a "General Model of Contextualised Computer Science Education"}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82953}, pages = {397 -- 400}, year = {2015}, language = {en} } @article{Buechner2015, author = {B{\"u}chner, Steffen}, title = {Empirical and Normative Research on Fundamental Ideas of Embedded System Development}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82949}, pages = {393 -- 396}, year = {2015}, language = {en} } @article{ZierisGerstbergerMueller2015, author = {Zieris, Holger and Gerstberger, Herbert and M{\"u}ller, Wolfgang}, title = {Using Arduino-Based Experiments to Integrate Computer Science Education and Natural Science}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82938}, pages = {381 -- 389}, year = {2015}, abstract = {Current curricular trends require teachers in Baden- Wuerttemberg (Germany) to integrate Computer Science (CS) into traditional subjects, such as Physical Science. However, concrete guidelines are missing. To fill this gap, we outline an approach where a microcontroller is used to perform and evaluate measurements in the Physical Science classroom. Using the open-source Arduino platform, we expect students to acquire and develop both CS and Physical Science competencies by using a self-programmed microcontroller. In addition to this combined development of competencies in Physical Science and CS, the subject matter will be embedded in suitable contexts and learning environments, such as weather and climate.}, language = {en} } @article{SysłoKwiatkowska2015, author = {Sysło, Maciej M. and Kwiatkowska, Anna Beata}, title = {Think logarithmically!}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82923}, pages = {371 -- 380}, year = {2015}, abstract = {We discuss here a number of algorithmic topics which we use in our teaching and in learning of mathematics and informatics to illustrate and document the power of logarithm in designing very efficient algorithms and computations - logarithmic thinking is one of the most important key competencies for solving real world practical problems. We demonstrate also how to introduce logarithm independently of mathematical formalism using a conceptual model for reducing a problem size by at least half. It is quite surprising that the idea, which leads to logarithm, is present in Euclid's algorithm described almost 2000 years before John Napier invented logarithm.}, language = {en} } @article{ReynoldsSwainstonBendrups2015, author = {Reynolds, Nicholas and Swainston, Andrew and Bendrups, Faye}, title = {Music Technology and Computational Thinking}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82913}, pages = {363 -- 370}, year = {2015}, abstract = {A project involving the composition of a number of pieces of music by public participants revealed levels of engagement with and mastery of complex music technologies by a number of secondary student volunteers. This paper reports briefly on some initial findings of that project and seeks to illuminate an understanding of computational thinking across the curriculum.}, language = {en} } @article{PrzybyllaRomeike2015, author = {Przybylla, Mareen and Romeike, Ralf}, title = {Key Competences with Physical Computing}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82904}, pages = {351 -- 361}, year = {2015}, abstract = {Physical computing covers the design and realization of interactive objects and installations and allows students to develop concrete, tangible products of the real world that arise from the learners' imagination. This way, constructionist learning is raised to a level that enables students to gain haptic experience and thereby concretizes the virtual. In this paper the defining characteristics of physical computing are described. Key competences to be gained with physical computing will be identified.}, language = {en} } @article{PrestonYounie2015, author = {Preston, Christina and Younie, Sarah}, title = {Mentoring in a Digital World}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82895}, pages = {343 -- 350}, year = {2015}, abstract = {This paper focuses on the results of the evaluation of the first pilot of an e-mentoring unit designed by the Hands-On ICT consortium, funded by the EU LLL programme. The overall aim of this two-year activity is to investigate the value for professional learning of Massive Online Open Courses (MOOCs) and Community Online Open Courses (COOCs) in the context of a 'community of practice'. Three units in the first pilot covered aspects of using digital technologies to develop creative thinking skills. The findings in this paper relate to the fourth unit about e-mentoring, a skill that was important to delivering the course content in the other three units. Findings about the e-mentoring unit included: the students' request for detailed profiles so that participants can get to know each other; and, the need to reconcile the different interpretations of e-mentoring held by the participants when the course begins. The evaluators concluded that the major issues were that: not all professional learners would self-organise and network; and few would wish to mentor their colleagues voluntarily. Therefore, the e-mentoring issues will need careful consideration in pilots two and three to identify how e-mentoring will be organised.}, language = {en} } @article{OrBach2015, author = {Or-Bach, Rachel}, title = {Programming for Non-Programmers}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82875}, pages = {335 -- 342}, year = {2015}, abstract = {The study reported in this paper involved the employment of specific in-class exercises using a Personal Response System (PRS). These exercises were designed with two goals: to enhance students' capabilities of tracing a given code and of explaining a given code in natural language with some abstraction. The paper presents evidence from the actual use of the PRS along with students' subjective impressions regarding both the use of the PRS and the special exercises. The conclusions from the findings are followed with a short discussion on benefits of PRS-based mental processing exercises for learning programming and beyond.}, language = {en} } @article{Ohrndorf2015, author = {Ohrndorf, Laura}, title = {Assignments in Computer Science Education}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82868}, pages = {327 -- 333}, year = {2015}, abstract = {In this paper we describe the recent state of our research project concerning computer science teachers' knowledge on students' cognition. We did a comprehensive analysis of textbooks, curricula and other resources, which give teachers guidance to formulate assignments. In comparison to other subjects there are only a few concepts and strategies taught to prospective computer science teachers in university. We summarize them and given an overview on our empirical approach to measure this knowledge.}, language = {en} } @article{MainaAngondiWaga2015, author = {Maina, Anthony Gioko and Angondi, Enos Kiforo and Waga, Rosemary}, title = {How does the Implementation of a Literacy Learning Tool Kit influence Literacy Skill Acquisition?}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82856}, pages = {319 -- 326}, year = {2015}, abstract = {This study aimed at following how teachers transfer skills into results while using ABRA literacy software. This was done in the second part of the pilot study whose aim was to provide equity to control group teachers and students by exposing them to the ABRACADABRA treatment after the end of phase 1. This opportunity was used to follow the phase 1 teachers to see how the skills learned were being transformed into results. A standard three-day initial training and planning session on how to use ABRA to teach literacy was held at the beginning of each phase for ABRA teachers (phase 1 experimental and phase 2 delayed ABRA). Teachers were provided with teaching materials including a tentative ABRA curriculum developed to align with the Kenyan English Language requirements for year 1 and 3 students. Results showed that although there was no significant difference between the groups in vocabulary-related subscales which include word reading and meaning as well as sentence comprehension, students in ABRACADABRA classes improved their scores at a significantly higher rate than students in control classes in comprehension related scores. An average student in the ABRACADABRA group improved by 12 and 16 percentile points respectively compared to their counterparts in the control group.}, language = {en} } @article{ChristensenKnezek2015, author = {Christensen, Rhonda and Knezek, Gerald}, title = {The Technology Proficiency Self-Assessment Questionnaire (TPSA)}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82838}, pages = {311 -- 318}, year = {2015}, abstract = {The Technology Proficiency Self-Assessment (TPSA) questionnaire has been used for 15 years in the USA and other nations as a self-efficacy measure for proficiencies fundamental to effective technology integration in the classroom learning environment. Internal consistency reliabilities for each of the five-item scales have typically ranged from .73 to .88 for preservice or inservice technology-using teachers. Due to changing technologies used in education, researchers sought to renovate partially obsolete items and extend self-efficacy assessment to new areas, such as social media and mobile learning. Analysis of 2014 data gathered on a new, 34 item version of the TPSA indicates that the four established areas of email, World Wide Web (WWW), integrated applications, and teaching with technology continue to form consistent scales with reliabilities ranging from .81 to .93, while the 14 new items gathered to represent emerging technologies and media separate into two scales, each with internal consistency reliabilities greater than .9. The renovated TPSA is deemed to be worthy of continued use in the teaching with technology context.}, language = {en} } @article{BottinoChioccariello2015, author = {Bottino, Rosa and Chioccariello, Augusto}, title = {Computational Thinking}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82820}, pages = {301 -- 309}, year = {2015}, abstract = {Digital technology has radically changed the way people work in industry, finance, services, media and commerce. Informatics has contributed to the scientific and technological development of our society in general and to the digital revolution in particular. Computational thinking is the term indicating the key ideas of this discipline that might be included in the key competencies underlying the curriculum of compulsory education. The educational potential of informatics has a history dating back to the sixties. In this article, we briefly revisit this history looking for lessons learned. In particular, we focus on experiences of teaching and learning programming. However, computational thinking is more than coding. It is a way of thinking and practicing interactive dynamic modeling with computers. We advocate that learners can practice computational thinking in playful contexts where they can develop personal projects, for example building videogames and/or robots, share and discuss their construction with others. In our view, this approach allows an integration of computational thinking in the K-12 curriculum across disciplines.}, language = {en} } @article{Weigend2015, author = {Weigend, Michael}, title = {How Things Work}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82814}, pages = {285 -- 298}, year = {2015}, abstract = {Recognizing and defining functionality is a key competence adopted in all kinds of programming projects. This study investigates how far students without specific informatics training are able to identify and verbalize functions and parameters. It presents observations from classroom activities on functional modeling in high school chemistry lessons with altogether 154 students. Finally it discusses the potential of functional modelling to improve the comprehension of scientific content.}, language = {en} } @article{Webb2015, author = {Webb, Mary}, title = {Considerations for the Design of Computing Curricula}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82723}, pages = {267 -- 283}, year = {2015}, abstract = {This paper originated from discussions about the need for important changes in the curriculum for Computing including two focus group meetings at IFIP conferences over the last two years. The paper examines how recent developments in curriculum, together with insights from curriculum thinking in other subject areas, especially mathematics and science, can inform curriculum design for Computing. The analysis presented in the paper provides insights into the complexity of curriculum design as well as identifying important constraints and considerations for the ongoing development of a vision and framework for a Computing curriculum.}, language = {en} } @article{Saito2015, author = {Saito, Toshinori}, title = {The Key Competencies in Informatics and ICT viewed from Nussbaum's Ten Central Capabilities}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82718}, pages = {253 -- 266}, year = {2015}, abstract = {This article shows a discussion about the key competencies in informatics and ICT viewed from a philosophical foundation presented by Martha Nussbaum, which is known as 'ten central capabilities'. Firstly, the outline of 'The Capability Approach', which has been presented by Amartya Sen and Nussbaum as a theoretical framework of assessing the state of social welfare, will be explained. Secondly, the body of Nussbaum's ten central capabilities and the reason for being applied as the basis of discussion will be shown. Thirdly, the relationship between the concept of 'capability' and 'competency' is to be discussed. After that, the author's assumption of the key competencies in informatics and ICT led from the examination of Nussbaum's ten capabilities will be presented.}, language = {en} } @article{PassigTzurielKedmi2015, author = {Passig, David and Tzuriel, David and Kedmi, Ganit Eshel}, title = {Improving children's Cognitive Modifiability through Mediated Learning and Dynamic Assessment within 3D Immersive Virtual Reality Environment}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82705}, pages = {235 -- 252}, year = {2015}, abstract = {The objectives of this study were to examine (a) the effect of dynamic assessment (DA) in a 3D Immersive Virtual Reality (IVR) environment as compared with computerized 2D and noncomputerized (NC) situations on cognitive modifiability, and (b) the transfer effects of these conditions on more difficult problem solving administered two weeks later in a non-computerized environment. A sample of 117 children aged 6:6-9:0 years were randomly assigned into three experimental groups of DA conditions: 3D, 2D, and NC, and one control group (C). All groups received the pre- and post-teaching Analogies subtest of the Cognitive Modifiability Battery (CMB-AN). The experimental groups received a teaching phase in conditions similar to the pre-and post-teaching phases. The findings showed that cognitive modifiability, in a 3D IVR, was distinctively higher than in the two other experimental groups (2D computer group and NC group). It was also found that the 3D group showed significantly higher performance in transfer problems than the 2D and NC groups.}, language = {en} } @article{OpelKramerTrommenetal.2015, author = {Opel, Simone and Kramer, Matthias and Trommen, Michael and Pottb{\"a}cker, Florian and Ilaghef, Youssef}, title = {BugHunt}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82693}, pages = {217 -- 233}, year = {2015}, abstract = {Competencies related to operating systems and computer security are usually taught systematically. In this paper we present a different approach, in which students have to remove virus-like behaviour on their respective computers, which has been induced by software developed for this purpose. They have to develop appropriate problem-solving strategies and thereby explore essential elements of the operating system. The approach was implemented exemplarily in two computer science courses at a regional general upper secondary school and showed great motivation and interest in the participating students.}, language = {en} } @article{MagenheimNellesNeugebaueretal.2015, author = {Magenheim, Johannes and Nelles, Wolfgang and Neugebauer, Jonas and Ohrndorf, Laura and Schaper, Niclas and Schubert, Sigrid}, title = {Expert Rating of Competence Levels in Upper Secondary Computer Science Education}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82683}, pages = {199 -- 216}, year = {2015}, abstract = {In the project MoKoM, which is funded by the German Research Foundation (DFG) from 2008 to 2012, a test instrument measuring students' competences in computer science was developed. This paper presents the results of an expert rating of the levels of students' competences done for the items of the instrument. At first we will describe the difficulty-relevant features that were used for the evaluation. These were deduced from computer science, psychological and didactical findings and resources. Potentials and desiderata of this research method are discussed further on. Finally we will present our conclusions on the results and give an outlook on further steps.}, language = {en} } @article{LewinMcNicol2015, author = {Lewin, Cathy and McNicol, Sarah}, title = {Supporting the Development of 21st Century Skills through ICT}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82672}, pages = {181 -- 198}, year = {2015}, abstract = {The growing impact of globalisation and the development of a 'knowledge society' have led many to argue that 21st century skills are essential for life in twenty-first century society and that ICT is central to their development. This paper describes how 21st century skills, in particular digital literacy, critical thinking, creativity, communication and collaboration skills, have been conceptualised and embedded in the resources developed for teachers in iTEC, a four-year, European project. The effectiveness of this approach is considered in light of the data collected through the evaluation of the pilots, which considers both the potential benefits of using technology to support the development of 21st century skills, but also the challenges of doing so. Finally, the paper discusses the learning support systems required in order to transform pedagogies and embed 21st century skills. It is argued that support is required in standards and assessment; curriculum and instruction; professional development; and learning environments.}, language = {en} } @article{Jones2015, author = {Jones, Anthony}, title = {ICT Competencies for School Students}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82663}, pages = {171 -- 179}, year = {2015}, abstract = {This paper discusses results from a small-scale research study, together with some recently published research into student perceptions of ICT for learning in schools, to consider relevant skills that do not appear to currently being taught. The paper concludes by raising three issues relating to learning with and through ICT that need to be addressed in school curricula and classroom teaching.}, language = {en} } @article{Haugsbakken2015, author = {Haugsbakken, Halvdan}, title = {The Student Learning Ecology}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82659}, pages = {151 -- 169}, year = {2015}, abstract = {Educational research on social media has showed that students use it for socialisation, personal communication, and informal learning. Recent studies have argued that students to some degree use social media to carry out formal schoolwork. This article gives an explorative account on how a small sample of Norwegian high school students use social media to self-organise formal schoolwork. This user pattern can be called a "student learning ecology", which is a user perspective on how participating students gain access to learning resources.}, language = {en} } @article{GrillenbergerRomeike2015, author = {Grillenberger, Andreas and Romeike, Ralf}, title = {Teaching Data Management}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82648}, pages = {133 -- 150}, year = {2015}, abstract = {Data management is a central topic in computer science as well as in computer science education. Within the last years, this topic is changing tremendously, as its impact on daily life becomes increasingly visible. Nowadays, everyone not only needs to manage data of various kinds, but also continuously generates large amounts of data. In addition, Big Data and data analysis are intensively discussed in public dialogue because of their influences on society. For the understanding of such discussions and for being able to participate in them, fundamental knowledge on data management is necessary. Especially, being aware of the threats accompanying the ability to analyze large amounts of data in nearly real-time becomes increasingly important. This raises the question, which key competencies are necessary for daily dealings with data and data management. In this paper, we will first point out the importance of data management and of Big Data in daily life. On this basis, we will analyze which are the key competencies everyone needs concerning data management to be able to handle data in a proper way in daily life. Afterwards, we will discuss the impact of these changes in data management on computer science education and in particular database education.}, language = {en} } @article{EllisAbreuEllis2015, author = {Ellis, Jason Brent and Abreu-Ellis, Carla Reis}, title = {Student Perspectives of Social Networking use in Higher Education}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82632}, pages = {117 -- 131}, year = {2015}, abstract = {Social networks are currently at the forefront of tools that lend to Personal Learning Environments (PLEs). This study aimed to observe how students perceived PLEs, what they believed were the integral components of social presence when using Facebook as part of a PLE, and to describe student's preferences for types of interactions when using Facebook as part of their PLE. This study used mixed methods to analyze the perceptions of graduate and undergraduate students on the use of social networks, more specifically Facebook as a learning tool. Fifty surveys were returned representing a 65 \% response rate. Survey questions included both closed and open-ended questions. Findings suggested that even though students rated themselves relatively well in having requisite technology skills, and 94 \% of students used Facebook primarily for social use, they were hesitant to migrate these skills to academic use because of concerns of privacy, believing that other platforms could fulfil the same purpose, and by not seeing the validity to use Facebook in establishing social presence. What lies at odds with these beliefs is that when asked to identify strategies in Facebook that enabled social presence to occur in academic work, the majority of students identified strategies in five categories that lead to social presence establishment on Facebook during their coursework.}, language = {en} } @article{DagieneStupuriene2015, author = {Dagiene, Valentina and Stupuriene, Gabriele}, title = {Informatics Education based on Solving Attractive Tasks through a Contest}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82626}, pages = {97 -- 115}, year = {2015}, abstract = {The paper discusses the issue of supporting informatics (computer science) education through competitions for lower and upper secondary school students (8-19 years old). Competitions play an important role for learners as a source of inspiration, innovation, and attraction. Running contests in informatics for school students for many years, we have noticed that the students consider the contest experience very engaging and exciting as well as a learning experience. A contest is an excellent instrument to involve students in problem solving activities. An overview of infrastructure and development of an informatics contest from international level to the national one (the Bebras contest on informatics and computer fluency, originated in Lithuania) is presented. The performance of Bebras contests in 23 countries during the last 10 years showed an unexpected and unusually high acceptance by school students and teachers. Many thousands of students participated and got a valuable input in addition to their regular informatics lectures at school. In the paper, the main attention is paid to the developed tasks and analysis of students' task solving results in Lithuania.}, language = {en} } @article{BroekerKastensMagenheim2015, author = {Br{\"o}ker, Kathrin and Kastens, Uwe and Magenheim, Johannes}, title = {Competences of Undergraduate Computer Science Students}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82613}, pages = {77 -- 96}, year = {2015}, abstract = {The paper presents two approaches to the development of a Computer Science Competence Model for the needs of curriculum development and evaluation in Higher Education. A normativetheoretical approach is based on the AKT and ACM/IEEE curriculum and will be used within the recommendations of the German Informatics Society (GI) for the design of CS curricula. An empirically oriented approach refines the categories of the first one with regard to specific subject areas by conducting content analysis on CS curricula of important universities from several countries. The refined model will be used for the needs of students' e-assessment and subsequent affirmative action of the CS departments.}, language = {en} } @article{BarnesKennewell2015, author = {Barnes, Jan and Kennewell, Steve}, title = {Teacher Perceptions of Key Competencies in ICT}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82604}, pages = {61 -- 75}, year = {2015}, abstract = {Regardless of what is intended by government curriculum specifications and advised by educational experts, the competencies taught and learned in and out of classrooms can vary considerably. In this paper, we discuss in particular how we can investigate the perceptions that individual teachers have of competencies in ICT, and how these and other factors may influence students' learning. We report case study research which identifies contradictions within the teaching of ICT competencies as an activity system, highlighting issues concerning the object of the curriculum, the roles of the participants and the school cultures. In a particular case, contradictions in the learning objectives between higher order skills and the use of application tools have been resolved by a change in the teacher's perceptions which have not led to changes in other aspects of the activity system. We look forward to further investigation of the effects of these contradictions in other case studies and on forthcoming curriculum change.}, language = {en} } @article{MagenheimSchubertSchapert2015, author = {Magenheim, Johannes and Schubert, Sigrid and Schapert, Niclas}, title = {Modelling and Measurement of Competencies in Computer Science Education}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82592}, pages = {33 -- 57}, year = {2015}, abstract = {As a result of the Bologna reform of educational systems in Europe the outcome orientation of learning processes, competence-oriented descriptions of the curricula and competence-oriented assessment procedures became standard also in Computer Science Education (CSE). The following keynote addresses important issues of shaping a CSE competence model especially in the area of informatics system comprehension and object-oriented modelling. Objectives and research methodology of the project MoKoM (Modelling and Measurement of Competences in CSE) are explained. Firstly, the CSE competence model was derived based on theoretical concepts and then secondly the model was empirically examined and refined using expert interviews. Furthermore, the paper depicts the development and examination of a competence measurement instrument, which was derived from the competence model. Therefore, the instrument was applied to a large sample of students at the gymnasium's upper class level. Subsequently, efforts to develop a competence level model, based on the retrieved empirical results and on expert ratings are presented. Finally, further demands on research on competence modelling in CSE will be outlined.}, language = {en} } @article{Kalas2015, author = {Kalas, Ivan}, title = {Programming at Pre-primary and Primary Levels}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82587}, pages = {29 -- 31}, year = {2015}, language = {en} } @article{Curzon2015, author = {Curzon, Paul}, title = {Unplugged Computational Thinking for Fun}, series = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, journal = {KEYCIT 2014 - Key Competencies in Informatics and ICT}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1868-0844}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-82575}, pages = {15 -- 27}, year = {2015}, abstract = {Computational thinking is a fundamental skill set that is learned by studying Informatics and ICT. We argue that its core ideas can be introduced in an inspiring and integrated way to both teachers and students using fun and contextually rich cs4fn 'Computer Science for Fun' stories combined with 'unplugged' activities including games and magic tricks. We also argue that understanding people is an important part of computational thinking. Computational thinking can be fun for everyone when taught in kinaesthetic ways away from technology.}, language = {en} } @article{MoserTschakertMuelleretal.2015, author = {Moser, Othmar and Tschakert, Gerhard and M{\"u}ller, Alexander and Groeschl, Werner and Pieber, Thomas R. and Obermayer-Pietsch, Barbara and Koehler, Gerd and Hofmann, Peter}, title = {Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {8}, publisher = {Public Library of Science}, address = {Lawrence}, issn = {1932-6203}, doi = {10.1371/journal.pone.0136489}, pages = {17}, year = {2015}, abstract = {Introduction We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM). Material and Methods Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/ Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25\% (A), 50\% (B), and 75\% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system. Results BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C. Conclusion Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM.}, language = {en} } @article{JahnBuschmannHille2015, author = {Jahn, Karolina and Buschmann, Volker and Hille, Carsten}, title = {Simultaneous Fluorescence and Phosphorescence Lifetime Imaging Microscopy in Living Cells}, series = {Scientific Reports}, journal = {Scientific Reports}, number = {5}, publisher = {Nature Publishing Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/srep14334}, pages = {13}, year = {2015}, abstract = {In living cells, there are always a plethora of processes taking place at the same time. Their precise regulation is the basis of cellular functions, since small failures can lead to severe dysfunctions. For a comprehensive understanding of intracellular homeostasis, simultaneous multiparameter detection is a versatile tool for revealing the spatial and temporal interactions of intracellular parameters. Here, a recently developed time-correlated single-photon counting (TCSPC) board was evaluated for simultaneous fluorescence and phosphorescence lifetime imaging microscopy (FLIM/PLIM). Therefore, the metabolic activity in insect salivary glands was investigated by recording ns-decaying intrinsic cellular fluorescence, mainly related to oxidized flavin adenine dinucleotide (FAD) and the μs-decaying phosphorescence of the oxygen-sensitive ruthenium-complex Kr341. Due to dopamine stimulation, the metabolic activity of salivary glands increased, causing a higher pericellular oxygen consumption and a resulting increase in Kr341 phosphorescence decay time. Furthermore, FAD fluorescence decay time decreased, presumably due to protein binding, thus inducing a quenching of FAD fluorescence decay time. Through application of the metabolic drugs antimycin and FCCP, the recorded signals could be assigned to a mitochondrial origin. The dopamine-induced changes could be observed in sequential FLIM and PLIM recordings, as well as in simultaneous FLIM/PLIM recordings using an intermediate TCSPC timing resolution.}, language = {en} } @article{Kroener2015, author = {Kr{\"o}ner, Dominik}, title = {Laser-driven electron dynamics for circular dichroism in mass spectrometry}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, volume = {29}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, number = {17}, publisher = {The Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/C5CP02193F}, pages = {19643 -- 19655}, year = {2015}, abstract = {The distinction of enantiomers is a key aspect of chemical analysis. In mass spectrometry the distinction of enantiomers has been achieved by ionizing the sample with circularly polarized laser pulses and comparing the ion yields for light of opposite handedness. While resonant excitation conditions are expected to be most efficient, they are not required for the detection of a circular dichroism (CD) in the ion yield. However, the prediction of the size and sign of the circular dichroism becomes challenging if non-resonant multiphoton excitations are used to ionize the sample. Employing femtosecond laser pulses to drive electron wavepacket dynamics based on ab initio calculations, we attempt to reveal underlying mechanisms that determine the CD under non-resonant excitation conditions. Simulations were done for (R)-1,2-propylene oxide, using time-dependent configuration interaction singles with perturbative doubles (TD-CIS(D)) and the aug-cc-pVTZ basis set. Interactions between the electric field and the electric dipole and quadrupole as well as between the magnetic field and the magnetic dipole were explicitly accounted for. The ion yield was determined by treating states above the ionization potential as either stationary or non-stationary with energy-dependent lifetimes based on an approved heuristic approach. The observed population dynamics do not allow for a simple interpretation, because of highly non-linear interactions. Still, the various transition pathways are governed by resonant enantiospecific n-photon excitation, with preferably high transition dipole moments, which eventually dominate the CD in the ionized population.}, language = {en} } @article{LohrenBornhorstGallaetal.2015, author = {Lohren, Hanna and Bornhorst, Julia and Galla, Hans-Joachim and Schwerdtle, Tanja}, title = {The blood-cerebrospinal fluid barrier}, series = {Metallomics : integrated biometal science}, volume = {10}, journal = {Metallomics : integrated biometal science}, number = {7}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, doi = {10.1039/C5MT00171D}, pages = {1420 -- 1430}, year = {2015}, abstract = {Exposure to organic mercury compounds promotes primarily neurological effects. Although methylmercury is recognized as a potent neurotoxicant, its transfer into the central nervous system (CNS) is not fully evaluated. While methylmercury and thiomersal pass the blood-brain barrier, limited data are available regarding the second brain regulating interface, the blood-cerebrospinal fluid (CSF) barrier. This novel study was designed to investigate the effects of organic as well as inorganic mercury compounds on, and their transfer across, a porcine in vitro model of the blood-CSF barrier for the first time. The barrier system is significantly more sensitive towards organic Hg compounds as compared to inorganic compounds regarding the endpoints cytotoxicity and barrier integrity. Whereas there are low transfer rates from the blood side to the CSF side, our results strongly indicate an active transfer of the organic mercury compounds out of the CSF. These results are the first to demonstrate an efflux of organic mercury compounds regarding the CNS and provide a completely new approach in the understanding of mercury compounds specific transport.}, language = {en} } @article{MeyerRaberEbertetal.2015, author = {Meyer, S. and Raber, G. and Ebert, Franziska and Leffers, L. and M{\"u}ller, Sandra Marie and Taleshi, M. S. and Francesconi, Kevin A. and Schwerdtle, Tanja}, title = {In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites}, series = {Toxicology research}, volume = {5}, journal = {Toxicology research}, number = {4}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2045-4538}, doi = {10.1039/c5tx00122f}, pages = {1289 -- 1296}, year = {2015}, abstract = {Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAV causes effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAV in HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitro and in vivo toxicological characterisation of these arsenolipids.}, language = {en} } @article{KirchheckerTroegerMuellerBakeetal.2015, author = {Kirchhecker, Sarah and Tr{\"o}ger-M{\"u}ller, Steffen and Bake, Sebastian and Antonietti, Markus and Taubert, Andreas and Esposito, Davido}, title = {Renewable pyridinium ionic liquids from the continuous hydrothermal decarboxylation of furfural-amino acid derived pyridinium zwitterions}, series = {Green chemistry}, volume = {8}, journal = {Green chemistry}, number = {17}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9262}, doi = {10.1039/c5gc00913h}, pages = {4151 -- 4156}, year = {2015}, abstract = {Fully renewable pyridinium ionic liquids were synthesised via the hydrothermal decarboxylation of pyridinium zwitterions derived from furfural and amino acids in flow. The functionality of the resulting ionic liquid (IL) can be tuned by choice of different amino acids as well as different natural carboxylic acids as the counterions. A representative member of this new class of ionic liquids was successfully used for the synthesis of ionogels and as a solvent for the Heck coupling.}, language = {en} } @article{BartoloniJinMarcaidaetal.2015, author = {Bartoloni, Marco and Jin, Xian and Marcaida, Maria Jos{\´e} and Banha, Joao and Dibonaventura, Ivan and Bongoni, Swathi and Bartho, Kathrin and Gr{\"a}bner, Olivia and Sefkow, Michael and Darbre, Tamis and Reymond, Jean-Louis}, title = {Bridged bicyclic peptides as potential drug scaffolds}, series = {Chemical Science}, volume = {10}, journal = {Chemical Science}, number = {6}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2041-6520}, doi = {10.1039/C5SC01699A}, pages = {5473 -- 5490}, year = {2015}, abstract = {Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as norbornane. Diastereomeric norbornapeptides were investigated by 1H-NMR, X-ray crystallography and CD spectroscopy and found to represent rigid globular scaffolds stabilized by intramolecular backbone hydrogen bonds with scaffold geometries determined by the chirality of amino acid residues and sharing structural features of β-turns and α-helices. Proteome profiling by capture compound mass spectrometry (CCMS) led to the discovery of the norbornapeptide 27c binding selectively to calmodulin as an example of a BBP protein binder. This and other BBPs showed high stability towards proteolytic degradation in serum.}, language = {en} } @article{SchulzeUtechtMoldtetal.2015, author = {Schulze, Michael and Utecht, Manuel Martin and Moldt, Thomas and Przyrembel, Daniel and Gahl, Cornelius and Weinelt, Martin and Saalfrank, Peter and Tegeder, Petra}, title = {Nonlinear optical response of photochromic azobenzene-functionalized self-assembled monolayers}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, volume = {27}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European Chemical Societies}, number = {17}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/c5cp03093e}, pages = {18079 -- 18086}, year = {2015}, abstract = {The combination of photochromic and nonlinear optical (NLO) properties of azobenzene-functionalized self-assembled monolayers (SAMs) constitutes an intriguing step towards novel photonic and optoelectronic devices. By utilizing the second-order NLO process of second harmonic generation (SHG), supported by density-functional theory and correlated wave function method calculations, we demonstrate that the photochromic interface provides the necessary prerequisites en route towards possible future technical applications: we find a high NLO contrast on the order of 16\% between the switching states. These are furthermore accessible reversibly and with high efficiencies in terms of cross sections on the order of 10-18 cm2 for both photoisomerization reactions, i.e., drivable by means of low-power LED light sources. Finally, both photostationary states (PSSs) are thermally stable at ambient conditions.}, language = {en} } @article{GuhaWarsinkeTientcheuetal.2015, author = {Guha, S. and Warsinke, A. and Tientcheu, Ch. M. and Schmalz, K. and Meliani, C. and Wenger, Ch.}, title = {Label free sensing of creatinine using a 6 GHz CMOS near-field dielectric immunosensor}, series = {The analyst : the analytical journal of the Royal Society of Chemistry}, volume = {9}, journal = {The analyst : the analytical journal of the Royal Society of Chemistry}, number = {140}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0003-2654}, doi = {10.1039/c4an02194k}, pages = {3019 -- 3027}, year = {2015}, abstract = {In this work we present a CMOS high frequency direct immunosensor operating at 6 GHz (C-band) for label free determination of creatinine. The sensor is fabricated in standard 0.13 μm SiGe:C BiCMOS process. The report also demonstrates the ability to immobilize creatinine molecules on a Si3N4 passivation layer of the standard BiCMOS/CMOS process, therefore, evading any further need of cumbersome post processing of the fabricated sensor chip. The sensor is based on capacitive detection of the amount of non-creatinine bound antibodies binding to an immobilized creatinine layer on the passivated sensor. The chip bound antibody amount in turn corresponds indirectly to the creatinine concentration used in the incubation phase. The determination of creatinine in the concentration range of 0.88-880 μM is successfully demonstrated in this work. A sensitivity of 35 MHz/10 fold increase in creatinine concentration (during incubation) at the centre frequency of 6 GHz is gained by the immunosensor. The results are compared with a standard optical measurement technique and the dynamic range and sensitivity is of the order of the established optical indication technique. The C-band immunosensor chip comprising an area of 0.3 mm2 reduces the sensing area considerably, therefore, requiring a sample volume as low as 2 μl. The small analyte sample volume and label free approach also reduce the experimental costs in addition to the low fabrication costs offered by the batch fabrication technique of CMOS/BiCMOS process.}, language = {en} } @article{NiedlBeta2015, author = {Niedl, Robert Raimund and Beta, Carsten}, title = {Hydrogel-driven paper-based microfluidics}, series = {LAB on a chip : miniaturisation for chemistry and biology}, volume = {11}, journal = {LAB on a chip : miniaturisation for chemistry and biology}, number = {15}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1473-0197}, doi = {10.1039/c5lc00276a}, pages = {2452 -- 2459}, year = {2015}, abstract = {Paper-based microfluidics provide an inexpensive, easy to use technology for point-of-care diagnostics in developing countries. Here, we combine paper-based microfluidic devices with responsive hydrogels to add an entire new class of functions to these versatile low-cost fluidic systems. The hydrogels serve as fluid reservoirs. In response to an external stimulus, e.g. an increase in temperature, the hydrogels collapse and release fluid into the structured paper substrate. In this way, chemicals that are either stored on the paper substrate or inside the hydrogel pads can be dissolved, premixed, and brought to reaction to fulfill specific analytic tasks. We demonstrate that multi-step sequences of chemical reactions can be implemented in a paper-based system and operated without the need for external precision pumps. We exemplify this technology by integrating an antibody-based E. coli test on a small and easy to use paper device.}, language = {en} } @article{NoechelReddyWangetal.2015, author = {N{\"o}chel, Ulrich and Reddy, Chaganti Srinivasa and Wang, Ke and Cui, Jing and Zizak, Ivo and Behl, Marc and Kratz, Karl and Lendlein, Andreas}, title = {Nanostructural changes in crystallizable controlling units determine the temperature-memory of polymers}, series = {Journal of Materials Chemistry A, Materials for energy and sustainability}, volume = {16}, journal = {Journal of Materials Chemistry A, Materials for energy and sustainability}, number = {3}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2050-7488}, doi = {10.1039/c4ta06586g}, pages = {8284 -- 8293}, year = {2015}, abstract = {Temperature-memory polymers remember the temperature, where they were deformed recently, enabled by broad thermal transitions. In this study, we explored a series of crosslinked poly[ethylene-co-(vinyl acetate)] networks (cPEVAs) comprising crystallizable polyethylene (PE) controlling units exhibiting a pronounced temperature-memory effect (TME) between 16 and 99 °C related to a broad melting transition (∼100 °C). The nanostructural changes in such cPEVAs during programming and activation of the TME were analyzed via in situ X-ray scattering and specific annealing experiments. Different contributions to the mechanism of memorizing high or low deformation temperatures (Tdeform) were observed in cPEVA, which can be associated to the average PE crystal sizes. At high deformation temperatures (>50 °C), newly formed PE crystals, which are established during cooling when fixing the temporary shape, dominated the TME mechanism. In contrast, at low Tdeform (<50 °C), corresponding to a cold drawing scenario, the deformation led preferably to a disruption of existing large crystals into smaller ones, which then fix the temporary shape upon cooling. The observed mechanism of memorizing a deformation temperature might enable the prediction of the TME behavior and the knowledge based design of other TMPs with crystallizable controlling units.}, language = {en} } @article{MondalBehrensMatthesetal.2015, author = {Mondal, Suvendu Sekhar and Behrens, Karsten and Matthes, Philipp R. and Sch{\"o}nfeld, Fabian and Nitsch, J{\"o}rn and Steffen, Andreas and Primus, Philipp-Alexander and Kumke, Michael Uwe and M{\"u}ller-Buschbaum, Klaus and Holdt, Hans-J{\"u}rgen}, title = {White light emission of IFP-1 by in situ co-doping of the MOF pore system with Eu3+ and Tb3+}, series = {Journal of materials chemistry : C, Materials for optical and electronic devices}, volume = {18}, journal = {Journal of materials chemistry : C, Materials for optical and electronic devices}, number = {3}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {2050-7534}, doi = {10.1039/C4TC02919D}, pages = {4623 -- 4631}, year = {2015}, abstract = {Co-doping of the MOF 3∞[Zn(2-methylimidazolate-4-amide-5-imidate)] (IFP-1 = Imidazolate Framework Potsdam-1) with luminescent Eu3+ and Tb3+ ions presents an approach to utilize the porosity of the MOF for the intercalation of luminescence centers and for tuning of the chromaticity to the emission of white light of the quality of a three color emitter. Organic based fluorescence processes of the MOF backbone as well as metal based luminescence of the dopants are combined to one homogenous single source emitter while retaining the MOF's porosity. The lanthanide ions Eu3+ and Tb3+ were doped in situ into IFP-1 upon formation of the MOF by intercalation into the micropores of the growing framework without a structure directing effect. Furthermore, the color point is temperature sensitive, so that a cold white light with a higher blue content is observed at 77 K and a warmer white light at room temperature (RT) due to the reduction of the organic emission at higher temperatures. The study further illustrates the dependence of the amount of luminescent ions on porosity and sorption properties of the MOF and proves the intercalation of luminescence centers into the pore system by low-temperature site selective photoluminescence spectroscopy, SEM and EDX. It also covers an investigation of the border of homogenous uptake within the MOF pores and the formation of secondary phases of lanthanide formates on the surface of the MOF. Crossing the border from a homogenous co-doping to a two-phase composite system can be beneficially used to adjust the character and warmth of the white light. This study also describes two-color emitters of the formula Ln@IFP-1a-d (Ln: Eu, Tb) by doping with just one lanthanide Eu3+ or Tb3+.}, language = {en} } @article{MegowRoehrSchmidtamBuschetal.2015, author = {Megow, J{\"o}rg and R{\"o}hr, Merle I. S. and Schmidt am Busch, Marcel and Renger, Thomas and Mitrić, Roland and Kirstein, Stefan and Rabe, J{\"u}rgen P. and May, Volkhard}, title = {Site-dependence of van der Waals interaction explains exciton spectra of double-walled tubular J-aggregates}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, volume = {17}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, number = {10}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9084}, doi = {10.1039/c4cp05945j}, pages = {6741 -- 6747}, year = {2015}, abstract = {The simulation of the optical properties of supramolecular aggregates requires the development of methods, which are able to treat a large number of coupled chromophores interacting with the environment. Since it is currently not possible to treat large systems by quantum chemistry, the Frenkel exciton model is a valuable alternative. In this work we show how the Frenkel exciton model can be extended in order to explain the excitonic spectra of a specific double-walled tubular dye aggregate explicitly taking into account dispersive energy shifts of ground and excited states due to van der Waals interaction with all surrounding molecules. The experimentally observed splitting is well explained by the site-dependent energy shift of molecules placed at the inner or outer side of the double-walled tube, respectively. Therefore we can conclude that inclusion of the site-dependent dispersive effect in the theoretical description of optical properties of nanoscaled dye aggregates is mandatory.}, language = {en} } @article{CroneAschnerSchwerdtleetal.2015, author = {Crone, Barbara and Aschner, Michael A. and Schwerdtle, Tanja and Karst, Uwe and Bornhorst, Julia}, title = {Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS}, series = {Metallomics}, volume = {2015}, journal = {Metallomics}, number = {7}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-591X}, doi = {10.1039/c5mt00096c}, pages = {1189 -- 1195}, year = {2015}, abstract = {cis-Diamminedichloroplatinum(II) (Cisplatin) is one of the most important and frequently used cytostatic drugs for the treatment of various solid tumors. Herein, a laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) method incorporating a fast and simple sample preparation protocol was developed for the elemental mapping of Cisplatin in the model organism Caenorhabditis elegans (C. elegans). The method allows imaging of the spatially-resolved elemental distribution of platinum in the whole organism with respect to the anatomic structure in L4 stage worms at a lateral resolution of 5 μm. In addition, a dose- and time-dependent Cisplatin uptake was corroborated quantitatively by a total reflection X-ray fluorescence spectroscopy (TXRF) method, and the elemental mapping indicated that Cisplatin is located in the intestine and in the head of the worms. Better understanding of the distribution of Cisplatin in this well-established model organism will be instrumental in deciphering Cisplatin toxicity and pharmacokinetics. Since the cytostatic effect of Cisplatin is based on binding the DNA by forming intra- and interstrand crosslinks, the response of poly(ADP-ribose)metabolism enzyme 1 (pme-1) deletion mutants to Cisplatin was also examined. Loss of pme-1, which is the C. elegans ortholog of human poly(ADP-ribose) polymerase 1 (PARP-1) led to disturbed DNA damage response. With respect to survival and brood size, pme-1 deletion mutants were more sensitive to Cisplatin as compared to wildtype worms, while Cisplatin uptake was indistinguishable.}, language = {en} } @article{PietraLangGrebe2015, author = {Pietra, Stefano and Lang, Patricia and Grebe, Markus}, title = {SABRE is required for stabilization of root hair patterning in Arabidopsis thaliana}, series = {Physiologia Plantarum}, volume = {153}, journal = {Physiologia Plantarum}, number = {3}, doi = {DOI: 10.1111/ppl.12257}, pages = {440 -- 453}, year = {2015}, abstract = {Patterned differentiation of distinct cell types is essential for the development of multicellular organisms. The root epidermis of Arabidopsis thaliana is composed of alternating files of root hair and non-hair cells and represents a model system for studying the control of cell-fate acquisition. Epidermal cell fate is regulated by a network of genes that translate positional information from the underlying cortical cell layer into a specific pattern of differentiated cells. While much is known about the genes of this network, new players continue to be discovered. Here we show that the SABRE (SAB) gene, known to mediate microtubule organization, anisotropic cell growth and planar polarity, has an effect on root epidermal hair cell patterning. Loss of SAB function results in ectopic root hair formation and destabilizes the expression of cell fate and differentiation markers in the root epidermis, including expression of the WEREWOLF (WER) and GLABRA2 (GL2) genes. Double mutant analysis reveal that wer and caprice (cpc) mutants, defective in core components of the epidermal patterning pathway, genetically interact with sab. This suggests that SAB may act on epidermal patterning upstream of WER and CPC. Hence, we provide evidence for a role of SAB in root epidermal patterning by affecting cell-fate stabilization. Our work opens the door for future studies addressing SAB-dependent functions of the cytoskeleton during root epidermal patterning.}, language = {en} } @article{KieferClaesNzayisengaetal.2015, author = {Kiefer, Christian S. and Claes, Andrea R. and Nzayisenga, Jean-Claude and Pietra, Stefano and Stanislas, Thomas and Ikeda, Yoshihisa and Grebe, Markus}, title = {Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity}, series = {Development}, journal = {Development}, number = {142}, doi = {doi: 10.1242/dev.111013}, pages = {151 -- 161}, year = {2015}, abstract = {The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms. In the root of Arabidopsis thaliana, a concentration gradient of the phytohormone auxin coordinates polar recruitment of Rho-of-plant (ROP) to sites of polar epidermal hair initiation. However, little is known about cytoskeletal components and interactions that contribute to this planar polarity or about their relation to the patterning machinery. Here, we show that ACTIN7 (ACT7) represents a main actin isoform required for planar polarity of root hair positioning, interacting with the negative modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2). ACT7, AIP1-2 and their genetic interaction are required for coordinated planar polarity of ROP downstream of ethylene signalling. Strikingly, AIP1-2 displays hair cell file-enriched expression, restricted by WEREWOLF (WER)-dependent patterning and modified by ethylene and auxin action. Hence, our findings reveal AIP1-2, expressed under control of the WER-dependent patterning machinery and the ethylene signalling pathway, as a modulator of actin-mediated planar polarity.}, language = {en} } @article{MetzlerBauerRasmussenetal.2015, author = {Metzler, Ralf and Bauer, Maximilian and Rasmussen, Emil S. and Lomholt, Michael A.}, title = {Real sequence effects on the search dynamics of transcription factors on DNA}, series = {Scientific Reports}, volume = {5}, journal = {Scientific Reports}, number = {10072}, publisher = {Nature Publishing Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/srep10072}, year = {2015}, abstract = {Recent experiments show that transcription factors (TFs) indeed use the facilitated diffusion mechanism to locate their target sequences on DNA in living bacteria cells: TFs alternate between sliding motion along DNA and relocation events through the cytoplasm. From simulations and theoretical analysis we study the TF-sliding motion for a large section of the DNA-sequence of a common E. coli strain, based on the two-state TF-model with a fast-sliding search state and a recognition state enabling target detection. For the probability to detect the target before dissociating from DNA the TF-search times self-consistently depend heavily on whether or not an auxiliary operator (an accessible sequence similar to the main operator) is present in the genome section. Importantly, within our model the extent to which the interconversion rates between search and recognition states depend on the underlying nucleotide sequence is varied. A moderate dependence maximises the capability to distinguish between the main operator and similar sequences. Moreover, these auxiliary operators serve as starting points for DNA looping with the main operator, yielding a spectrum of target detection times spanning several orders of magnitude. Auxiliary operators are shown to act as funnels facilitating target detection by TFs.}, language = {en} } @article{HaendlerKlieglAdani2015, author = {Haendler, Yair and Kliegl, Reinhold and Adani, Flavia}, title = {Discourse accessibility constraints in children´s processing of object relative clauses}, series = {Frontiers in psychology}, volume = {6}, journal = {Frontiers in psychology}, number = {860}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2015.00860}, year = {2015}, abstract = {Children's poor performance on object relative clauses has been explained in terms of intervention locality. This approach predicts that object relatives with a full DP head and an embedded pronominal subject are easier than object relatives in which both the head noun and the embedded subject are full DPs. This prediction is shared by other accounts formulated to explain processing mechanisms. We conducted a visual-world study designed to test the off-line comprehension and on-line processing of object relatives in German-speaking 5-year-olds. Children were tested on three types of object relatives, all having a full DP head noun and differing with respect to the type of nominal phrase that appeared in the embedded subject position: another full DP, a 1st- or a 3rd-person pronoun. Grammatical skills and memory capacity were also assessed in order to see whether and how they affect children's performance. Most accurately processed were object relatives with 1st-person pronoun, independently of children's language and memory skills. Performance on object relatives with two full DPs was overall more accurate than on object relatives with 3rd-person pronoun. In the former condition, children with stronger grammatical skills accurately processed the structure and their memory abilities determined how fast they were; in the latter condition, children only processed accurately the structure if they were strong both in their grammatical skills and in their memory capacity. The results are discussed in the light of accounts that predict different pronoun effects like the ones we find, which depend on the referential properties of the pronouns. We then discuss which role language and memory abilities might have in processing object relatives with various embedded nominal phrases.}, language = {en} } @article{HaeusslerBader2015, author = {H{\"a}ussler, Jana and Bader, Markus}, title = {An interference account of the missing-VP effect}, series = {Frontiers in psychology}, volume = {6}, journal = {Frontiers in psychology}, number = {766}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2015.00766}, year = {2015}, abstract = {Sentences with doubly center-embedded relative clauses in which a verb phrase (VP) is missing are sometimes perceived as grammatical, thus giving rise to an illusion of grammaticality. In this paper, we provide a new account of why missing-VP sentences, which are both complex and ungrammatical, lead to an illusion of grammaticality, the so-called missing-VP effect. We propose that the missing-VP effect in particular, and processing difficulties with multiply center-embedded clauses more generally, are best understood as resulting from interference during cue-based retrieval. When processing a sentence with double center-embedding, a retrieval error due to interference can cause the verb of an embedded clause to be erroneously attached into a higher clause. This can lead to an illusion of grammaticality in the case of missing-VP sentences and to processing complexity in the case of complete sentences with double center-embedding. Evidence for an interference account of the missing-VP effect comes from experiments that have investigated the missing-VP effect in German using a speeded grammaticality judgments procedure. We review this evidence and then present two new experiments that show that the missing-VP effect can be found in German also with less restricting procedures. One experiment was a questionnaire study which required grammaticality judgments from participants without imposing any time constraints. The second experiment used a self-paced reading procedure and did not require any judgments. Both experiments confirm the prior findings of missing-VP effects in German and also show that the missing-VP effect is subject to a primacy effect as known from the memory literature. Based on this evidence, we argue that an account of missing-VP effects in terms of interference during cue-based retrieval is superior to accounts in terms of limited memory resources or in terms of experience with embedded structures.}, language = {en} } @article{FelserPattersonCunnings2015, author = {Felser, Claudia and Patterson, Clare and Cunnings, Ian}, title = {Structural constraints on pronoun binding and coreference: Evidence from eye movements during reading}, series = {Frontiers in psychology}, volume = {6}, journal = {Frontiers in psychology}, number = {840}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2015.00840}, year = {2015}, abstract = {A number of recent studies have investigated how syntactic and non-syntactic constraints combine to cue memory retrieval during anaphora resolution. In this paper we investigate how syntactic constraints and gender congruence interact to guide memory retrieval during the resolution of subject pronouns. Subject pronouns are always technically ambiguous, and the application of syntactic constraints on their interpretation depends on properties of the antecedent that is to be retrieved. While pronouns can freely corefer with non-quantified referential antecedents, linking a pronoun to a quantified antecedent is only possible in certain syntactic configurations via variable binding. We report the results from a judgment task and three online reading comprehension experiments investigating pronoun resolution with quantified and non-quantified antecedents. Results from both the judgment task and participants' eye movements during reading indicate that comprehenders freely allow pronouns to corefer with non-quantified antecedents, but that retrieval of quantified antecedents is restricted to specific syntactic environments. We interpret our findings as indicating that syntactic constraints constitute highly weighted cues to memory retrieval during anaphora resolution.}, language = {en} } @article{MetzlerCherstvyChechkinetal.2015, author = {Metzler, Ralf and Cherstvy, Andrey G. and Chechkin, Aleksei V. and Bodrova, Anna S.}, title = {Ultraslow scaled Brownian motion}, series = {New journal of physics : the open-access journal for physics}, volume = {17}, journal = {New journal of physics : the open-access journal for physics}, number = {063038}, publisher = {Dt. Physikalische Ges., IOP}, address = {Bad Honnef, London}, issn = {1367-2630}, doi = {10.1088/1367-2630/17/6/063038}, year = {2015}, abstract = {We define and study in detail utraslow scaled Brownian motion (USBM) characterized by a time dependent diffusion coefficient of the form . For unconfined motion the mean squared displacement (MSD) of USBM exhibits an ultraslow, logarithmic growth as function of time, in contrast to the conventional scaled Brownian motion. In a harmonic potential the MSD of USBM does not saturate but asymptotically decays inverse-proportionally to time, reflecting the highly non-stationary character of the process. We show that the process is weakly non-ergodic in the sense that the time averaged MSD does not converge to the regular MSD even at long times, and for unconfined motion combines a linear lag time dependence with a logarithmic term. The weakly non-ergodic behaviour is quantified in terms of the ergodicity breaking parameter. The USBM process is also shown to be ageing: observables of the system depend on the time gap between initiation of the test particle and start of the measurement of its motion. Our analytical results are shown to agree excellently with extensive computer simulations.}, language = {en} } @article{LamprechtMargaria2015, author = {Lamprecht, Anna-Lena and Margaria, Tiziana}, title = {Scientific workflows and XMDD}, series = {Process design for natural scientists}, journal = {Process design for natural scientists}, editor = {Lamprecht, Anna-Lena and Margaria, Tiziana}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45006-2}, pages = {1 -- 13}, year = {2015}, language = {en} } @article{Blaese2014, author = {Blaese, Leif}, title = {Data mining for unidentified protein squences}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {73 -- 87}, year = {2014}, abstract = {Through the use of next generation sequencing (NGS) technology, a lot of newly sequenced organisms are now available. Annotating those genes is one of the most challenging tasks in sequence biology. Here, we present an automated workflow to find homologue proteins, annotate sequences according to function and create a three-dimensional model.}, language = {en} } @article{Schuett2014, author = {Sch{\"u}tt, Christine}, title = {Identification of differentially expressed genes}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {127 -- 139}, year = {2014}, abstract = {With the jABC it is possible to realize workflows for numerous questions in different fields. The goal of this project was to create a workflow for the identification of differentially expressed genes. This is of special interest in biology, for it gives the opportunity to get a better insight in cellular changes due to exogenous stress, diseases and so on. With the knowledge that can be derived from the differentially expressed genes in diseased tissues, it becomes possible to find new targets for treatment.}, language = {en} } @article{Kuntzsch2014, author = {Kuntzsch, Christian}, title = {Visualization of data transfer paths}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {140 -- 148}, year = {2014}, abstract = {A workflow for visualizing server connections using the Google Maps API was built in the jABC. It makes use of three basic services: An XML-based IP address geolocation web service, a command line tool and the Static Maps API. The result of the workflow is an URL leading to an image file of a map, showing server connections between a client and a target host.}, language = {en} } @article{Teske2014, author = {Teske, Daniel}, title = {Geocoder accuracy ranking}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {161 -- 174}, year = {2014}, abstract = {Finding an address on a map is sometimes tricky: the chosen map application may be unfamiliar with the enclosed region. There are several geocoders on the market, they have different databases and algorithms to compute the query. Consequently, the geocoding results differ in their quality. Fortunately the geocoders provide a rich set of metadata. The workflow described in this paper compares this metadata with the aim to find out which geocoder is offering the best-fitting coordinate for a given address.}, language = {en} } @article{Schulze2014, author = {Schulze, Gunnar}, title = {Workflow for rapid metagenome analysis}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {88 -- 100}, year = {2014}, abstract = {Analyses of metagenomes in life sciences present new opportunities as well as challenges to the scientific community and call for advanced computational methods and workflows. The large amount of data collected from samples via next-generation sequencing (NGS) technologies render manual approaches to sequence comparison and annotation unsuitable. Rather, fast and efficient computational pipelines are needed to provide comprehensive statistics and summaries and enable the researcher to choose appropriate tools for more specific analyses. The workflow presented here builds upon previous pipelines designed for automated clustering and annotation of raw sequence reads obtained from next-generation sequencing technologies such as 454 and Illumina. Employing specialized algorithms, the sequence reads are processed at three different levels. First, raw reads are clustered at high similarity cutoff to yield clusters which can be exported as multifasta files for further analyses. Independently, open reading frames (ORFs) are predicted from raw reads and clustered at two strictness levels to yield sets of non-redundant sequences and ORF families. Furthermore, single ORFs are annotated by performing searches against the Pfam database}, language = {en} } @article{Sens2014, author = {Sens, Henriette}, title = {Web-Based map generalization tools put to the test: a jABC workflow}, series = {Process Design for Natural Scientists: an agile model-driven approach}, journal = {Process Design for Natural Scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {175 -- 185}, year = {2014}, abstract = {Geometric generalization is a fundamental concept in the digital mapping process. An increasing amount of spatial data is provided on the web as well as a range of tools to process it. This jABC workflow is used for the automatic testing of web-based generalization services like mapshaper.org by executing its functionality, overlaying both datasets before and after the transformation and displaying them visually in a .tif file. Mostly Web Services and command line tools are used to build an environment where ESRI shapefiles can be uploaded, processed through a chosen generalization service and finally visualized in Irfanview.}, language = {en} } @article{Noack2014, author = {Noack, Franziska}, title = {CREADED: Colored-Relief application for digital elevation data}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {186 -- 199}, year = {2014}, abstract = {In the geoinformatics field, remote sensing data is often used for analyzing the characteristics of the current investigation area. This includes DEMs, which are simple raster grids containing grey scales representing the respective elevation values. The project CREADED that is presented in this paper aims at making these monochrome raster images more significant and more intuitively interpretable. For this purpose, an executable interactive model for creating a colored and relief-shaded Digital Elevation Model (DEM) has been designed using the jABC framework. The process is based on standard jABC-SIBs and SIBs that provide specific GIS functions, which are available as Web services, command line tools and scripts.}, language = {en} } @article{Respondek2014, author = {Respondek, Tobias}, title = {A workflow for computing potential areas for wind turbines}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, pages = {200 -- 215}, year = {2014}, abstract = {This paper describes the implementation of a workflow model for service-oriented computing of potential areas for wind turbines in jABC. By implementing a re-executable model the manual effort of a multi-criteria site analysis can be reduced. The aim is to determine the shift of typical geoprocessing tools of geographic information systems (GIS) from the desktop to the web. The analysis is based on a vector data set and mainly uses web services of the "Center for Spatial Information Science and Systems" (CSISS). This paper discusses effort, benefits and problems associated with the use of the web services.}, language = {en} } @article{Scheele2014, author = {Scheele, Lasse}, title = {Location analysis for placing artificial reefs}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {216 -- 228}, year = {2014}, abstract = {Location analyses are among the most common tasks while working with spatial data and geographic information systems. Automating the most frequently used procedures is therefore an important aspect of improving their usability. In this context, this project aims to design and implement a workflow, providing some basic tools for a location analysis. For the implementation with jABC, the workflow was applied to the problem of finding a suitable location for placing an artificial reef. For this analysis three parameters (bathymetry, slope and grain size of the ground material) were taken into account, processed, and visualized with the The Generic Mapping Tools (GMT), which were integrated into the workflow as jETI-SIBs. The implemented workflow thereby showed that the approach to combine jABC with GMT resulted in an user-centric yet user-friendly tool with high-quality cartographic outputs.}, language = {en} } @article{Kind2014, author = {Kind, Josephine}, title = {Creation of topographic maps}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, pages = {229 -- 238}, year = {2014}, abstract = {Location analyses are among the most common tasks while working with spatial data and geographic information systems. Automating the most frequently used procedures is therefore an important aspect of improving their usability. In this context, this project aims to design and implement a workflow, providing some basic tools for a location analysis. For the implementation with jABC, the workflow was applied to the problem of finding a suitable location for placing an artificial reef. For this analysis three parameters (bathymetry, slope and grain size of the ground material) were taken into account, processed, and visualized with the The Generic Mapping Tools (GMT), which were integrated into the workflow as jETI-SIBs. The implemented workflow thereby showed that the approach to combine jABC with GMT resulted in an user-centric yet user-friendly tool with high-quality cartographic outputs.}, language = {en} } @article{Holler2014, author = {Holler, Robin}, title = {GraffDok - a graffiti documentation application}, series = {Process design for natural scientists: an agile model-driven approach}, journal = {Process design for natural scientists: an agile model-driven approach}, number = {500}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-662-45005-5}, issn = {1865-0929}, pages = {239 -- 251}, year = {2014}, abstract = {GraffDok is an application helping to maintain an overview over sprayed images somewhere in a city. At the time of writing it aims at vandalism rather than at beautiful photographic graffiti in an underpass. Looking at hundreds of tags and scribbles on monuments, house walls, etc. it would be interesting to not only record them in writing but even make them accessible electronically, including images. GraffDok's workflow is simple and only requires an EXIF-GPS-tagged photograph of a graffito. It automatically determines its location by using reverse geocoding with the given GPS-coordinates and the Gisgraphy WebService. While asking the user for some more meta data, GraffDok analyses the image in parallel with this and tries to detect fore- and background - before extracting the drawing lines and make them stand alone. The command line based tool ImageMagick is used here as well as for accessing EXIF data. Any meta data is written to csv-files, which will stay easily accessible and can be integrated in TeX-files as well. The latter ones are converted to PDF at the end of the workflow, containing a table about all graffiti and a summary for each - including the generated characteristic graffiti pattern image.}, language = {en} }