@misc{Spahn2016, author = {Spahn, Hannah}, title = {Republican, and a Tea Party Fanatic, All the While Being Dead}, series = {The American historical review}, volume = {121}, journal = {The American historical review}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0002-8762}, doi = {10.1093/ahr/121.3.933}, pages = {933 -- 934}, year = {2016}, language = {en} } @misc{RevereyGrossartPremkeetal.2016, author = {Reverey, Florian and Grossart, Hans-Peter and Premke, Katrin and Lischeid, Gunnar}, title = {Carbon and nutrient cycling in kettle hole sediments depending on hydrological dynamics: a review}, series = {Hydrobiologia : acta hydrobiologica, hydrographica, limnologica et protistologica}, volume = {775}, journal = {Hydrobiologia : acta hydrobiologica, hydrographica, limnologica et protistologica}, publisher = {Springer}, address = {Dordrecht}, issn = {0018-8158}, doi = {10.1007/s10750-016-2715-9}, pages = {1 -- 20}, year = {2016}, abstract = {Kettle holes as a specific group of isolated, small lentic freshwater systems (LFS) often are (i) hot spots of biogeochemical cycling and (ii) exposed to frequent sediment desiccation and rewetting. Their ecological functioning is greatly determined by immanent carbon and nutrient transformations. The objective of this review is to elucidate effects of a changing hydrological regime (i.e., dry-wet cycles) on carbon and nutrient cycling in kettle hole sediments. Generally, dry-wet cycles have the potential to increase C and N losses as well as P availability. However, their duration and frequency are important controlling factors regarding direction and intensity of biogeochemical and microbiological responses. To evaluate drought impacts on sediment carbon and nutrient cycling in detail requires the context of the LFS hydrological history. For example, frequent drought events induce physiological adaptation of exposed microbial communities and thus flatten metabolic responses, whereas rare events provoke unbalanced, strong microbial responses. Different potential of microbial resilience to drought stress can irretrievably change microbial communities and functional guilds, gearing cascades of functional responses. Hence, dry-wet events can shift the biogeochemical cycling of organic matter and nutrients to a new equilibrium, thus affecting the dynamic balance between carbon burial and mineralization in kettle holes.}, language = {en} } @misc{LesinskiPrieskeGranacher2016, author = {Lesinski, Melanie and Prieske, Olaf and Granacher, Urs}, title = {Effects and dose-response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis}, series = {British journal of sports medicine : the journal of sport and exercise medicine}, volume = {50}, journal = {British journal of sports medicine : the journal of sport and exercise medicine}, publisher = {BMJ Publishing Group}, address = {London}, issn = {0306-3674}, doi = {10.1136/bjsports-2015-095497}, pages = {781 -- 795}, year = {2016}, abstract = {Objectives To quantify age, sex, sport and training type-specific effects of resistance training on physical performance, and to characterise dose-response relationships of resistance training parameters that could maximise gains in physical performance in youth athletes. Design Systematic review and meta-analysis of intervention studies. Data sources Studies were identified by systematic literature search in the databases PubMed and Web of Science (1985-2015). Weighted mean standardised mean differences (SMDwm) were calculated using random-effects models. Eligibility criteria for selecting studies Only studies with an active control group were included if these investigated the effects of resistance training in youth athletes (6-18 years) and tested at least one physical performance measure. Results 43 studies met the inclusion criteria. Our analyses revealed moderate effects of resistance training on muscle strength and vertical jump performance (SMDwm 0.8-1.09), and small effects on linear sprint, agility and sport-specific performance (SMDwm 0.58-0.75). Effects were moderated by sex and resistance training type. Independently computed dose-response relationships for resistance training parameters revealed that a training period of >23 weeks, 5 sets/exercise, 6-8 repetitions/set, a training intensity of 80-89\% of 1 repetition maximum (RM), and 3-4 min rest between sets were most effective to improve muscle strength (SMDwm 2.09-3.40). Summary/conclusions Resistance training is an effective method to enhance muscle strength and jump performance in youth athletes, moderated by sex and resistance training type. Dose-response relationships for key training parameters indicate that youth coaches should primarily implement resistance training programmes with fewer repetitions and higher intensities to improve physical performance measures of youth athletes.}, language = {en} } @misc{MahlowOrzechowskiFettke2016, author = {Mahlow, Sebastian and Orzechowski, Slawomir and Fettke, J{\"o}rg}, title = {Starch phosphorylation: insights and perspectives}, series = {Cellular and molecular life sciences}, volume = {73}, journal = {Cellular and molecular life sciences}, publisher = {Springer}, address = {Basel}, issn = {1420-682X}, doi = {10.1007/s00018-016-2248-4}, pages = {2753 -- 2764}, year = {2016}, abstract = {During starch metabolism, the phosphorylation of glucosyl residues of starch, to be more precise of amylopectin, is a repeatedly observed process. This phosphorylation is mediated by dikinases, the glucan, water dikinase (GWD) and the phosphoglucan, water dikinase (PWD). The starch-related dikinases utilize ATP as dual phosphate donor transferring the terminal gamma-phosphate group to water and the beta-phosphate group selectively to either C6 position or C3 position of a glucosyl residue within amylopectin. By the collaborative action of both enzymes, the initiation of a transition of alpha-glucans from highly ordered, water-insoluble state to a less order state is realized and thus the initial process of starch degradation. Consequently, mutants lacking either GWD or PWD reveal a starch excess phenotype as well as growth retardation. In this review, we focus on the increased knowledge collected over the last years related to enzymatic properties, the precise definition of the substrates, the physiological implications, and discuss ongoing questions.}, language = {en} } @misc{MielkeVermassenEllenbecketal.2016, author = {Mielke, Jahel and Vermassen, Hannah and Ellenbeck, Saskia and Milan, Blanca Fernandez and Jaeger, Carlo}, title = {Stakeholder involvement in sustainability science-A critical view}, series = {Global biogeochemical cycles}, volume = {17}, journal = {Global biogeochemical cycles}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2214-6296}, doi = {10.1016/j.erss.2016.04.001}, pages = {71 -- 81}, year = {2016}, abstract = {Discussions about the opening of science to society have led to the emergence of new fields such as sustainability science and transformative science. At the same time, the megatrend of stakeholder participation reached the academic world and thus scientific research processes. This challenges the way science is conducted and the tools, methods and theories perceived appropriate. Although researchers involve stakeholders, the scientific community still lacks comprehensive theoretical analysis of the practical processes behind their integration - for example what kind of perceptions scientists have about their roles, their objectives, the knowledge to gather, their understanding of science or the science-policy interface. Our paper addresses this research gap by developing four ideal types of stakeholder involvement in science - the technocratic, the functionalist, the neoliberal-rational and the democratic type. In applying the typology, which is based on literature review, interviews and practical experiences, we identify and discuss three major criticisms raised towards stakeholder involvement in science: the legitimacy of stakeholder claims, the question whether bargaining or deliberation are part of the stakeholder involvement process and the question of the autonomy of science. Thus, the typology helps scientists to better understand the major critical questions that stakeholder involvement raises and enables them to position themselves when conducting their research. (C) 2016 Elsevier Ltd. All rights reserved.}, language = {en} } @misc{SchusterKrahe2016, author = {Schuster, Isabell and Krah{\´e}, Barbara}, title = {Abuse of Elders Living at Home: A Review of Recent Prevalence Studies}, series = {International Journal of Behavioral Science}, volume = {11}, journal = {International Journal of Behavioral Science}, publisher = {Behavioral Science Research Institute, Srinakharinwirot University}, address = {Bangkok}, issn = {1906-4675}, pages = {93 -- 108}, year = {2016}, abstract = {This article presents evidence from recent studies on the prevalence of different forms of elder abuse. After a review of definitions and measures of elder abuse, the findings of 20 original studies containing 26 samples from 17 countries published since 2010 are summarized. Overall prevalence rates showed a high variability across studies, ranging from 2.2\% in a study from Ireland to 43.7\% in a study from Egypt. Evidence on gender differences in the vulnerability for abuse and the predominant relationship constellations between abusers and victims did not yield a consistent picture across studies. Conceptual and methodological reasons for the variability in prevalence rates are discussed, and an outlook for future research is presented. In particular, consistent definitions and measures are needed to facilitate the comparative analysis of elder abuse in different studies and cultural contexts.}, language = {en} } @misc{CastroGruneSpeckmann2016, author = {Castro, Jos{\´e} Pedro and Grune, Tilman and Speckmann, Bodo}, title = {The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction}, series = {Biological chemistry}, volume = {397}, journal = {Biological chemistry}, publisher = {De Gruyter}, address = {Berlin}, issn = {1431-6730}, doi = {10.1515/hsz-2015-0305}, pages = {709 -- 724}, year = {2016}, abstract = {White adipose tissue (WAT) is actively involved in the regulation of whole-body energy homeostasis via storage/ release of lipids and adipokine secretion. Current research links WAT dysfunction to the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). The expansion of WAT during oversupply of nutrients prevents ectopic fat accumulation and requires proper preadipocyte-to-adipocyte differentiation. An assumed link between excess levels of reactive oxygen species (ROS), WAT dysfunction and T2D has been discussed controversially. While oxidative stress conditions have conclusively been detected in WAT of T2D patients and related animal models, clinical trials with antioxidants failed to prevent T2D or to improve glucose homeostasis. Furthermore, animal studies yielded inconsistent results regarding the role of oxidative stress in the development of diabetes. Here, we discuss the contribution of ROS to the (patho) physiology of adipocyte function and differentiation, with particular emphasis on sources and nutritional modulators of adipocyte ROS and their functions in signaling mechanisms controlling adipogenesis and functions of mature fat cells. We propose a concept of ROS balance that is required for normal functioning of WAT. We explain how both excessive and diminished levels of ROS, e. g. resulting from over supplementation with antioxidants, contribute to WAT dysfunction and subsequently insulin resistance.}, language = {en} } @misc{MengerYarmanErdoessyetal.2016, author = {Menger, Marcus and Yarman, Aysu and Erd{\"o}ssy, J{\´u}lia and Yildiz, Huseyin Bekir and Gyurcs{\´a}nyi, R{\´o}bert E. and Scheller, Frieder W.}, title = {MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing}, series = {Biosensors : open access journal}, volume = {6}, journal = {Biosensors : open access journal}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios6030035}, pages = {4399 -- 4413}, year = {2016}, abstract = {Biomimetic binders and catalysts have been generated in order to substitute the biological pendants in separation techniques and bioanalysis. The two major approaches use either "evolution in the test tube" of nucleotides for the preparation of aptamers or total chemical synthesis for molecularly imprinted polymers (MIPs). The reproducible production of aptamers is a clear advantage, whilst the preparation of MIPs typically leads to a population of polymers with different binding sites. The realization of binding sites in the total bulk of the MIPs results in a higher binding capacity, however, on the expense of the accessibility and exchange rate. Furthermore, the readout of the bound analyte is easier for aptamers since the integration of signal generating labels is well established. On the other hand, the overall negative charge of the nucleotides makes aptamers prone to non-specific adsorption of positively charged constituents of the sample and the "biological" degradation of non-modified aptamers and ionic strength-dependent changes of conformation may be challenging in some application.}, language = {en} } @misc{HeinzVossLawrieetal.2016, author = {Heinz, A. and Voss, M. and Lawrie, S. M. and Mishara, A. and Bauer, M. and Gallinat, J{\"u}rgen and Juckel, G. and Lang, U. and Rapp, Michael A. and Falkai, P. and Strik, W. and Krystal, J. and Abi-Dargham, A. and Galderisi, S.}, title = {Shall we really say goodbye to first rank symptoms?}, series = {European psychiatry : the journal of the Association of European Psychiatrists}, volume = {37}, journal = {European psychiatry : the journal of the Association of European Psychiatrists}, publisher = {Elsevier}, address = {Paris}, issn = {0924-9338}, doi = {10.1016/j.eurpsy.2016.04.010}, pages = {8 -- 13}, year = {2016}, abstract = {Background: First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A' symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10 is currently under revision and may follow suit. In this review, we discuss central points of criticism that are directed against the continuous use of first rank symptoms (FRS) to diagnose schizophrenia.}, language = {en} } @misc{SpellervandenHurkCharpentieretal.2016, author = {Speller, Camilla and van den Hurk, Youri and Charpentier, Anne and Rodrigues, Ana and Gardeisen, Armelle and Wilkens, Barbara and McGrath, Krista and Rowsell, Keri and Spindler, Luke and Collins, Matthew J. and Hofreiter, Michael}, title = {Barcoding the largest animals on Earth: ongoing challenges and molecular solutions in the taxonomic identification of ancient cetaceans}, series = {Philosophical transactions of the Royal Society of London : B, Biological sciences}, volume = {371}, journal = {Philosophical transactions of the Royal Society of London : B, Biological sciences}, publisher = {Royal Society}, address = {London}, issn = {0962-8436}, doi = {10.1098/rstb.2015.0332}, pages = {11}, year = {2016}, language = {en} }