@misc{HeinzBeckRapp2016,
  author    = {Heinz, Andreas and Beck, Anne and Rapp, Michael Armin},
  title     = {Alcohol as an Environmental Mortality Hazard},
  series = {JAMA psychiatry},
  volume    = {73},
  journal   = {JAMA psychiatry},
  publisher = {American Veterinary Medical Association},
  address   = {Chicago},
  issn      = {2168-622X},
  doi       = {10.1001/jamapsychiatry.2016.0399},
  pages     = {549 -- 550},
  year      = {2016},
  language  = {en}
}
@article{BakanidzeBrandlHutzleretal.2016,
  author    = {Bakanidze, George and Brandl, Eva J. and Hutzler, Christine and Aurass, Friederike and Onken, Silke and Rapp, Michael Armin and Puls, Imke},
  title     = {Association of Dystrobrevin-Binding Protein 1 Polymorphisms with Sustained Attention and Set-Shifting in Schizophrenia Patients},
  series = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
  volume    = {74},
  journal   = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0302-282X},
  doi       = {10.1159/000450550},
  pages     = {41 -- 47},
  year      = {2016},
  abstract  = {Background: Despite extensive research in the past decades, the influence of genetics on cognitive functions in schizophrenia remains unclear. Dystrobrevin-binding protein 1 (DTNBP1) is one of the most promising candidate genes in schizophrenia. An association of DTNBP1 with cognitive dysfunction, particularly memory impairment, has been reported in a number of studies. However, the results remain inconsistent. The aim of this study was to measure the association between DTNBP1 polymorphisms and cognitive domains in a well-characterized sample. Methods: Ninety-one clinically stable schizophrenia outpatients underwent a battery of cognitive tests. Six single nucleotide polymorphisms (SNPs) of DTNBP1 were genotyped in all participants. Statistical and multivariate analyses were performed. Results: Factor analysis revealed 4 factors corresponding to distinct cognitive domains, namely sustained attention, set-shifting, executive functioning, and memory. We found a significant association of the rs909706 polymorphism with attention (p = 0.030) and a nonsignificant trend for set-shifting (p = 0.060). The other SNPs and haplotypes were not associated with cognitive function. Discussion: Replication of this finding in a larger sample is needed in order to confirm the importance of this particular polymorphism in the genetics of schizophrenia, particularly the distinct cognitive domains. In conclusion, the present study supports the involvement of DTNBP1 in the regulation of cognitive processes and demonstrates association in particular with sustained attention and set-shifting in schizophrenia patients. (C) 2016 S. Karger AG, Basel},
  language  = {en}
}
@article{DrosselmeyerRappHadjietal.2016,
  author    = {Drosselmeyer, J. and Rapp, Michael Armin and Hadji, P. and Kostev, K.},
  title     = {Depression risk in female patients with osteoporosis in primary care practices in Germany},
  series = {Osteoporosis international},
  volume    = {27},
  journal   = {Osteoporosis international},
  publisher = {Springer},
  address   = {London},
  issn      = {0937-941X},
  doi       = {10.1007/s00198-016-3584-9},
  pages     = {2739 -- 2744},
  year      = {2016},
  abstract  = {The Summary Thirty-five thousand four hundred eighty-three female osteoporosis patients were compared with 35,483 patients without osteoporosis regarding the incidence of depression. The risk of depression is significantly increased for patients with osteoporosis compared with patients without osteoporosis in primary care practices within Germany. Introduction The objectives of the present study were to analyze the incidence of depression in German female patients with osteoporosis and to evaluate the risk factors for depression diagnosis within this patient population. Methods This study was a retrospective database analysis conducted in Germany utilizing the Disease Analyzer (R) Database (IMS Health, Germany). The study population included 70,966 patients between 40 and 80 years of age from 1072 primary care practices. The observation period was between 2004 and 2013. Follow-up duration was 5 years and was completed in April 2015. A total of 35,483 osteoporosis patients were selected after applying exclusion criteria, and 35,483 controls were chosen and then matched (1:1) to osteoporosis patients based on age, sex, health insurance coverage, depression diagnosis in the past, and follow-up duration after index date. The analyses of depression-free survival were carried out using Kaplan-Meier curves and log-rank tests. Cox proportional hazards models (dependent variable: depression) were used to adjust for confounders. Results Depression diagnoses were presented in 33.0\% of the osteoporosis group and 22.7\% of the control group after the 5-year follow-up (p < 0.001). Dementia, cancer, heart failure, coronary heart disease, and diabetes were associated with a higher risk of developing depression (p < 0.001). Private health insurance was associated with a lower risk of depression. There was no significant effect of fractures on depression risk. Conclusion The risk of depression is significantly increased for patients with osteoporosis in primary care practices within Germany.},
  language  = {en}
}
@article{KonradJacobRappetal.2016,
  author    = {Konrad, Marcel and Jacob, Louis and Rapp, Michael Armin and Kostev, Karel},
  title     = {Depression risk in patients with coronary heart disease in Germany},
  series = {World Journal of Cardiology},
  volume    = {8},
  journal   = {World Journal of Cardiology},
  publisher = {Baishideng Publishing Group},
  address   = {Pleasanton},
  issn      = {1949-8462},
  doi       = {10.4330/wjc.v8.i9.547},
  pages     = {547 -- 552},
  year      = {2016},
  abstract  = {AIM To determine the prevalence of depression and its risk factors among patients with coronary heart disease (CHD) treated in German primary care practices. METHODS Longitudinal data from nationwide general practices in Germany (n = 1072) were analyzed. Individuals initially diagnosed with CHD (2009-2013) were identified, and 59992 patients were included and matched (1: 1) to 59992 controls. The primary outcome measure was an initial diagnosis of depression within five years after the index date among patients with and without CHD. Cox proportional hazards models were used to adjust for confounders. RESULTS Mean age was equal to 68.0 years (SD = 11.3). A total of 55.9\% of patients were men. After a five-year follow-up, 21.8\% of the CHD group and 14.2\% of the control group were diagnosed with depression (P < 0.001). In the multivariate regression model, CHD was a strong risk factor for developing depression (HR = 1.54, 95\% CI: 1.49-1.59, P < 0.001). Prior depressive episodes, dementia, and eight other chronic conditions were associated with a higher risk of developing depression. Interestingly, older patients and women were also more likely to be diagnosed with depression compared with younger patients and men, respectively. CONCLUSION The risk of depression is significantly increased among patients with CHD compared with patients without CHD treated in primary care practices in Germany. CHD patients should be routinely screened for depression to ensure improved treatment and management.},
  language  = {en}
}
@article{KonradBohlkenRappetal.2016,
  author    = {Konrad, Marcel and Bohlken, Jens and Rapp, Michael Armin and Kostev, Karel},
  title     = {Depression risk in patients with heart failure in primary care practices in Germany},
  series = {International psychogeriatrics},
  volume    = {28},
  journal   = {International psychogeriatrics},
  publisher = {Cambridge Univ. Press},
  address   = {New York},
  issn      = {1041-6102},
  doi       = {10.1017/S1041610216000867},
  pages     = {1889 -- 1894},
  year      = {2016},
  abstract  = {Background: The goal of this study was to estimate the prevalence of and risk factors for diagnosed depression in heart failure (HF) patients in German primary care practices. Methods: This study was a retrospective database analysis in Germany utilizing the Disease Analyzer (R) Database (IMS Health, Germany). The study population included 132,994 patients between 40 and 90 years of age from 1,072 primary care practices. The observation period was between 2004 and 2013. Follow-up lasted up to five years and ended in April 2015. A total of 66,497 HF patients were selected after applying exclusion criteria. The same number of 66,497 controls were chosen and were matched (1:1) to HF patients on the basis of age, sex, health insurance, depression diagnosis in the past, and follow-up duration after index date. Results: HF was a strong risk factor for diagnosed depression (p < 0.0001). A total of 10.5\% of HF patients and 6.3\% of matched controls developed depression after one year of follow-up (p < 0.001). Depression was documented in 28.9\% of the HF group and 18.2\% of the control group after the five-year follow-up (p < 0.001). Cancer, dementia, osteoporosis, stroke, and osteoarthritis were associated with a higher risk of developing depression. Male gender and private health insurance were associated with lower risk of depression. Conclusions: The risk of diagnosed depression is significantly increased in patients with HF compared to patients without HF in primary care practices in Germany.},
  language  = {en}
}
@misc{KonradBohlkenRappetal.2016,
  author    = {Konrad, Marcel and Bohlken, Jens and Rapp, Michael Armin and Kostev, Karel},
  title     = {Depression risk in patients with heart failure in primary care practices in Germany},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {458},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414159},
  pages     = {6},
  year      = {2016},
  abstract  = {Background: The goal of this study was to estimate the prevalence of and risk factors for diagnosed depression in heart failure (HF) patients in German primary care practices. Methods: This study was a retrospective database analysis in Germany utilizing the Disease Analyzer (R) Database (IMS Health, Germany). The study population included 132,994 patients between 40 and 90 years of age from 1,072 primary care practices. The observation period was between 2004 and 2013. Follow-up lasted up to five years and ended in April 2015. A total of 66,497 HF patients were selected after applying exclusion criteria. The same number of 66,497 controls were chosen and were matched (1:1) to HF patients on the basis of age, sex, health insurance, depression diagnosis in the past, and follow-up duration after index date. Results: HF was a strong risk factor for diagnosed depression (p < 0.0001). A total of 10.5\% of HF patients and 6.3\% of matched controls developed depression after one year of follow-up (p < 0.001). Depression was documented in 28.9\% of the HF group and 18.2\% of the control group after the five-year follow-up (p < 0.001). Cancer, dementia, osteoporosis, stroke, and osteoarthritis were associated with a higher risk of developing depression. Male gender and private health insurance were associated with lower risk of depression. Conclusions: The risk of diagnosed depression is significantly increased in patients with HF compared to patients without HF in primary care practices in Germany.},
  language  = {en}
}
@misc{HeinzKlugeRapp2016,
  author    = {Heinz, A. and Kluge, U. and Rapp, Michael Armin},
  title     = {Heritability of living in deprived neighbourhoods},
  series = {Translational Psychiatry},
  volume    = {6},
  journal   = {Translational Psychiatry},
  publisher = {Nature Publ. Group},
  address   = {New York},
  issn      = {2158-3188},
  doi       = {10.1038/tp.2016.215},
  pages     = {1},
  year      = {2016},
  language  = {en}
}
@misc{HeinzKlugeRapp2016,
  author    = {Heinz, A. and Kluge, U. and Rapp, Michael Armin},
  title     = {Heritability of living in deprived neighbourhoods},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-103770},
  pages     = {1},
  year      = {2016},
  language  = {en}
}
@misc{LiuSchadKuschpeletal.2016,
  author    = {Liu, Shuyan and Schad, Daniel and Kuschpel, Maxim S. and Rapp, Michael Armin and Heinz, Andreas},
  title     = {Music and Video Gaming during Breaks},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-90700},
  pages     = {1 -- 12},
  year      = {2016},
  abstract  = {Different systems for habitual versus goal-directed control are thought to underlie human decision-making. Working memory is known to shape these decision-making systems and their interplay, and is known to support goal-directed decision making even under stress. Here, we investigated if and how decision systems are differentially influenced by breaks filled with diverse everyday life activities known to modulate working memory performance. We used a within-subject design where young adults listened to music and played a video game during breaks interleaved with trials of a sequential two-step Markov decision task, designed to assess habitual as well as goal-directed decision making. Based on a neurocomputational model of task performance, we observed that for individuals with a rather limited working memory capacity video gaming as compared to music reduced reliance on the goal-directed decision-making system, while a rather large working memory capacity prevented such a decline. Our findings suggest differential effects of everyday activities on key decision-making processes.},
  language  = {en}
}
@article{LiuSchadKuschpeletal.2016,
  author    = {Liu, Shuyan and Schad, Daniel and Kuschpel, Maxim S. and Rapp, Michael Armin and Heinz, Andreas},
  title     = {Music and Video Gaming during Breaks},
  series = {PLoS one},
  volume    = {11},
  journal   = {PLoS one},
  number    = {3},
  publisher = {Public Library of Science},
  address   = {Lawrence, Kan.},
  issn      = {1932-6203},
  doi       = {10.1371/JOURNAL.PONE.0150165},
  pages     = {1 -- 12},
  year      = {2016},
  abstract  = {Different systems for habitual versus goal-directed control are thought to underlie human decision-making. Working memory is known to shape these decision-making systems and their interplay, and is known to support goal-directed decision making even under stress. Here, we investigated if and how decision systems are differentially influenced by breaks filled with diverse everyday life activities known to modulate working memory performance. We used a within-subject design where young adults listened to music and played a video game during breaks interleaved with trials of a sequential two-step Markov decision task, designed to assess habitual as well as goal-directed decision making. Based on a neurocomputational model of task performance, we observed that for individuals with a rather limited working memory capacity video gaming as compared to music reduced reliance on the goal-directed decision-making system, while a rather large working memory capacity prevented such a decline. Our findings suggest differential effects of everyday activities on key decision-making processes.},
  language  = {en}
}