@phdthesis{Herenz2014, author = {Herenz, Peter}, title = {A study of the absorption characteristics of gaseous galaxy halos in the local Universe}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70513}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {Today, it is well known that galaxies like the Milky Way consist not only of stars but also of gas and dust. The galactic halo, a sphere of gas that surrounds the stellar disk of a galaxy, is especially interesting. It provides a wealth of information about in and outflowing gaseous material towards and away from galaxies and their hierarchical evolution. For the Milky Way, the so-called high-velocity clouds (HVCs), fast moving neutral gas complexes in the halo that can be traced by absorption-line measurements, are believed to play a crucial role in the overall matter cycle in our Galaxy. Over the last decades, the properties of these halo structures and their connection to the local circumgalactic and intergalactic medium (CGM and IGM, respectively) have been investigated in great detail by many different groups. So far it remains unclear, however, to what extent the results of these studies can be transferred to other galaxies in the local Universe. In this thesis, we study the absorption properties of Galactic HVCs and compare the HVC absorption characteristics with those of intervening QSO absorption-line systems at low redshift. The goal of this project is to improve our understanding of the spatial extent and physical conditions of gaseous galaxy halos in the local Universe. In the first part of the thesis we use HST /STIS ultraviolet spectra of more than 40 extragalactic background sources to statistically analyze the absorption properties of the HVCs in the Galactic halo. We determine fundamental absorption line parameters including covering fractions of different weakly/intermediately/highly ionized metals with a particular focus on SiII and MgII. Due to the similarity in the ionization properties of SiII and MgII, we are able to estimate the contribution of HVC-like halo structures to the cross section of intervening strong MgII absorbers at z = 0. Our study implies that only the most massive HVCs would be regarded as strong MgII absorbers, if the Milky Way halo would be seen as a QSO absorption line system from an exterior vantage point. Combining the observed absorption-cross section of Galactic HVCs with the well-known number density of intervening strong MgII absorbers at z = 0, we conclude that the contribution of infalling gas clouds (i.e., HVC analogs) in the halos of Milky Way-type galaxies to the cross section of strong MgII absorbers is 34\%. This result indicates that only about one third of the strong MgII absorption can be associated with HVC analogs around other galaxies, while the majority of the strong MgII systems possibly is related to galaxy outflows and winds. The second part of this thesis focuses on the properties of intervening metal absorbers at low redshift. The analysis of the frequency and physical conditions of intervening metal systems in QSO spectra and their relation to nearby galaxies offers new insights into the typical conditions of gaseous galaxy halos. One major aspect in our study was to regard intervening metal systems as possible HVC analogs. We perform a detailed analysis of absorption line properties and line statistics for 57 metal absorbers along 78 QSO sightlines using newly-obtained ultraviolet spectra obtained with HST /COS. We find clear evidence for bimodal distribution in the HI column density in the absorbers, a trend that we interpret as sign for two different classes of absorption systems (with HVC analogs at the high-column density end). With the help of the strong transitions of SiII λ1260, SiIII λ1206, and CIII λ977 we have set up Cloudy photoionization models to estimate the local ionization conditions, gas densities, and metallicities. We find that the intervening absorption systems studied by us have, on average, similar physical conditions as Galactic HVC absorbers, providing evidence that many of them represent HVC analogs in the vicinity of other galaxies. We therefore determine typical halo sizes for SiII, SiIII, and CIII for L = 0.01L∗ and L = 0.05L∗ galaxies. Based on the covering fractions of the different ions in the Galactic halo, we find that, for example, the typical halo size for SiIII is ∼ 160 kpc for L = 0.05L∗ galaxies. We test the plausibility of this result by searching for known galaxies close to the QSO sightlines and at similar redshifts as the absorbers. We find that more than 34\% of the measured SiIII absorbers have galaxies associated with them, with the majority of the absorbers indeed being at impact parameters ρ ≤160 kpc.}, language = {en} } @phdthesis{Yadavalli2014, author = {Yadavalli, Nataraja Sekhar}, title = {Advances in experimental methods to probe surface relief grating formation mechanism in photosensitive materials}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-71213}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {When azobenzene-modified photosensitive polymer films are irradiated with light interference patterns, topographic variations in the film develop that follow the electric field vector distribution resulting in the formation of surface relief grating (SRG). The exact correspondence of the electric field vector orientation in interference pattern in relation to the presence of local topographic minima or maxima of SRG is in general difficult to determine. In my thesis, we have established a systematic procedure to accomplish the correlation between different interference patterns and the topography of SRG. For this, we devise a new setup combining an atomic force microscope and a two-beam interferometer (IIAFM). With this set-up, it is possible to track the topography change in-situ, while at the same time changing polarization and phase of the impinging interference pattern. To validate our results, we have compared two photosensitive materials named in short as PAZO and trimer. This is the first time that an absolute correspondence between the local distribution of electric field vectors of interference pattern and the local topography of the relief grating could be established exhaustively. In addition, using our IIAFM we found that for a certain polarization combination of two orthogonally polarized interfering beams namely SP (↕, ↔) interference pattern, the topography forms SRG with only half the period of the interference patterns. Exploiting this phenomenon we are able to fabricate surface relief structures below diffraction limit with characteristic features measuring only 140 nm, by using far field optics with a wavelength of 491 nm. We have also probed for the stresses induced during the polymer mass transport by placing an ultra-thin gold film on top (5-30 nm). During irradiation, the metal film not only deforms along with the SRG formation, but ruptures in regular and complex manner. The morphology of the cracks differs strongly depending on the electric field distribution in the interference pattern even when the magnitude and the kinetic of the strain are kept constant. This implies a complex local distribution of the opto-mechanical stress along the topography grating. The neutron reflectivity measurements of the metal/polymer interface indicate the penetration of metal layer within the polymer resulting in the formation of bonding layer that confirms the transduction of light induced stresses in the polymer layer to a metal film.}, language = {en} } @book{Pilipenko2014, author = {Pilipenko, Andrey}, title = {An introduction to stochastic differential equations with reflection}, series = {Lectures in pure and applied mathematics}, journal = {Lectures in pure and applied mathematics}, number = {1}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-297-1}, issn = {2199-4951}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70782}, publisher = {Universit{\"a}t Potsdam}, pages = {ix, 75}, year = {2014}, abstract = {These lecture notes are intended as a short introduction to diffusion processes on a domain with a reflecting boundary for graduate students, researchers in stochastic analysis and interested readers. Specific results on stochastic differential equations with reflecting boundaries such as existence and uniqueness, continuity and Markov properties, relation to partial differential equations and submartingale problems are given. An extensive list of references to current literature is included. This book has its origins in a mini-course the author gave at the University of Potsdam and at the Technical University of Berlin in Winter 2013.}, language = {en} } @phdthesis{Tenenboim2014, author = {Tenenboim, Yehezkel}, title = {Characterization of a Chlamydomonas protein involved in cell division and autophagy}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70650}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {The contractile vacuole (CV) is an osmoregulatory organelle found exclusively in algae and protists. In addition to expelling excessive water out of the cell, it also expels ions and other metabolites and thereby contributes to the cell's metabolic homeostasis. The interest in the CV reaches beyond its immediate cellular roles. The CV's function is tightly related to basic cellular processes such as membrane dynamics and vesicle budding and fusion; several physiological processes in animals, such as synaptic neurotransmission and blood filtration in the kidney, are related to the CV's function; and several pathogens, such as the causative agents of sleeping sickness, possess CVs, which may serve as pharmacological targets. The green alga Chlamydomonas reinhardtii has two CVs. They are the smallest known CVs in nature, and they remain relatively untouched in the CV-related literature. Many genes that have been shown to be related to the CV in other organisms have close homologues in C. reinhardtii. We attempted to silence some of these genes and observe the effect on the CV. One of our genes, VMP1, caused striking, severe phenotypes when silenced. Cells exhibited defective cytokinesis and aberrant morphologies. The CV, incidentally, remained unscathed. In addition, mutant cells showed some evidence of disrupted autophagy. Several important regulators of the cell cycle as well as autophagy were found to be underexpressed in the mutant. Lipidomic analysis revealed many meaningful changes between wild-type and mutant cells, reinforcing the compromised-autophagy observation. VMP1 is a singular protein, with homologues in numerous eukaryotic organisms (aside from fungi), but usually with no relatives in each particular genome. Since its first characterization in 2002 it has been associated with several cellular processes and functions, namely autophagy, programmed cell-death, secretion, cell adhesion, and organelle biogenesis. It has been implicated in several human diseases: pancreatitis, diabetes, and several types of cancer. Our results reiterate some of the observations in VMP1's six reported homologues, but, importantly, show for the first time an involvement of this protein in cell division. The mechanisms underlying this involvement in Chlamydomonas, as well as other key aspects, such as VMP1's subcellular localization and interaction partners, still await elucidation.}, language = {en} } @article{Cheesman2014, author = {Cheesman, Samantha Joy}, title = {Comparative Perspectives on Plea Bargaining in Germany and the U.S.A.}, series = {Rechtsentwicklungen aus europ{\"a}ischer Perspektive im 21. Jahrhundert}, journal = {Rechtsentwicklungen aus europ{\"a}ischer Perspektive im 21. Jahrhundert}, number = {2}, editor = {Bad{\´o}, Attila and Belling, Detlev W.}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-74572}, pages = {113 -- 151}, year = {2014}, language = {en} } @article{Huber2014, author = {Huber, Jasmina}, title = {Competing Musical Traditions in the Holy Land in the 20th Century and How They Found Their Way into the Synagogue of Belgrade}, series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, volume = {20}, journal = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1614-6492}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-69234}, pages = {87 -- 98}, year = {2014}, abstract = {The development of the current liturgical music used in the Belgrade synagogue is (in the last decades) heavily influenced by foreign traditions (mostly levantine) that are brought to Belgrade by modern communication systems. Therefore it is nearly impossible to speak of a status quo that might be possibly obsolete by tomorrow - at least with respect to the melodies. The great changes within the liturgical music occurred not due to acculturation into the Serbian majority but due to the personal preferences of the religious leaders of the Belgrade Jews. The alterations are a conscious process which is precisely the consequence of the musical taste of the local Rabbi and Cantor and not occurring autonomously. In order to understand the new nusah sepharadiyerushalmi that took the place of the forlorn nusah after the downfall of the Communist regime it is deemed necessary to look towards Israel where the rite developed.}, language = {en} } @phdthesis{Schmidl2014, author = {Schmidl, Ricarda}, title = {Empirical essays on job search behavior, active labor market policies, and propensity score balancing methods}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-71145}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {In Chapter 1 of the dissertation, the role of social networks is analyzed as an important determinant in the search behavior of the unemployed. Based on the hypothesis that the unemployed generate information on vacancies through their social network, search theory predicts that individuals with large social networks should experience an increased productivity of informal search, and reduce their search in formal channels. Due to the higher productivity of search, unemployed with a larger network are also expected to have a higher reservation wage than unemployed with a small network. The model-theoretic predictions are tested and confirmed empirically. It is found that the search behavior of unemployed is significantly affected by the presence of social contacts, with larger networks implying a stronger substitution away from formal search channels towards informal channels. The substitution is particularly pronounced for passive formal search methods, i.e., search methods that generate rather non-specific types of job offer information at low relative cost. We also find small but significant positive effects of an increase of the network size on the reservation wage. These results have important implications on the analysis of the job search monitoring or counseling measures that are usually targeted at formal search only. Chapter 2 of the dissertation addresses the labor market effects of vacancy information during the early stages of unemployment. The outcomes considered are the speed of exit from unemployment, the effects on the quality of employment and the short-and medium-term effects on active labor market program (ALMP) participation. It is found that vacancy information significantly increases the speed of entry into employment; at the same time the probability to participate in ALMP is significantly reduced. Whereas the long-term reduction in the ALMP arises in consequence of the earlier exit from unemployment, we also observe a short-run decrease for some labor market groups which suggest that caseworker use high and low intensity activation measures interchangeably which is clearly questionable from an efficiency point of view. For unemployed who find a job through vacancy information we observe a small negative effect on the weekly number of hours worked. In Chapter 3, the long-term effects of participation in ALMP are assessed for unemployed youth under 25 years of age. Complementary to the analysis in Chapter 2, the effects of participation in time- and cost-intensive measures of active labor market policies are examined. In particular we study the effects of job creation schemes, wage subsidies, short-and long-term training measures and measures to promote the participation in vocational training. The outcome variables of interest are the probability to be in regular employment, and participation in further education during the 60 months following program entry. The analysis shows that all programs, except job creation schemes have positive and long-term effects on the employment probability of youth. In the short-run only short-term training measures generate positive effects, as long-term training programs and wage subsidies exhibit significant locking-in'' effects. Measures to promote vocational training are found to increase the probability of attending education and training significantly, whereas all other programs have either no or a negative effect on training participation. Effect heterogeneity with respect to the pre-treatment level education shows that young people with higher pre-treatment educational levels benefit more from participation most programs. However, for longer-term wage subsidies we also find strong positive effects for young people with low initial education levels. The relative benefit of training measures is higher in West than in East Germany. In the evaluation studies of Chapters 2 and 3 semi-parametric balancing methods of Propensity Score Matching (PSM) and Inverse Probability Weighting (IPW) are used to eliminate the effects of counfounding factors that influence both the treatment participation as well as the outcome variable of interest, and to establish a causal relation between program participation and outcome differences. While PSM and IPW are intuitive and methodologically attractive as they do not require parametric assumptions, the practical implementation may become quite challenging due to their sensitivity to various data features. Given the importance of these methods in the evaluation literature, and the vast number of recent methodological contributions in this field, Chapter 4 aims to reduce the knowledge gap between the methodological and applied literature by summarizing new findings of the empirical and statistical literature and practical guidelines for future applied research. In contrast to previous publications this study does not only focus on the estimation of causal effects, but stresses that the balancing challenge can and should be discussed independent of question of causal identification of treatment effects on most empirical applications. Following a brief outline of the practical implementation steps required for PSM and IPW, these steps are presented in detail chronologically, outlining practical advice for each step. Subsequently, the topics of effect estimation, inference, sensitivity analysis and the combination with parametric estimation methods are discussed. Finally, new extensions of the methodology and avenues for future research are presented.}, language = {en} } @phdthesis{Hebig2014, author = {Hebig, Regina}, title = {Evolution of model-driven engineering settings in practice}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70761}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {Nowadays, software systems are getting more and more complex. To tackle this challenge most diverse techniques, such as design patterns, service oriented architectures (SOA), software development processes, and model-driven engineering (MDE), are used to improve productivity, while time to market and quality of the products stay stable. Multiple of these techniques are used in parallel to profit from their benefits. While the use of sophisticated software development processes is standard, today, MDE is just adopted in practice. However, research has shown that the application of MDE is not always successful. It is not fully understood when advantages of MDE can be used and to what degree MDE can also be disadvantageous for productivity. Further, when combining different techniques that aim to affect the same factor (e.g. productivity) the question arises whether these techniques really complement each other or, in contrast, compensate their effects. Due to that, there is the concrete question how MDE and other techniques, such as software development process, are interrelated. Both aspects (advantages and disadvantages for productivity as well as the interrelation to other techniques) need to be understood to identify risks relating to the productivity impact of MDE. Before studying MDE's impact on productivity, it is necessary to investigate the range of validity that can be reached for the results. This includes two questions. First, there is the question whether MDE's impact on productivity is similar for all approaches of adopting MDE in practice. Second, there is the question whether MDE's impact on productivity for an approach of using MDE in practice remains stable over time. The answers for both questions are crucial for handling risks of MDE, but also for the design of future studies on MDE success. This thesis addresses these questions with the goal to support adoption of MDE in future. To enable a differentiated discussion about MDE, the term MDE setting'' is introduced. MDE setting refers to the applied technical setting, i.e. the employed manual and automated activities, artifacts, languages, and tools. An MDE setting's possible impact on productivity is studied with a focus on changeability and the interrelation to software development processes. This is done by introducing a taxonomy of changeability concerns that might be affected by an MDE setting. Further, three MDE traits are identified and it is studied for which manifestations of these MDE traits software development processes are impacted. To enable the assessment and evaluation of an MDE setting's impacts, the Software Manufacture Model language is introduced. This is a process modeling language that allows to reason about how relations between (modeling) artifacts (e.g. models or code files) change during application of manual or automated development activities. On that basis, risk analysis techniques are provided. These techniques allow identifying changeability risks and assessing the manifestations of the MDE traits (and with it an MDE setting's impact on software development processes). To address the range of validity, MDE settings from practice and their evolution histories were capture in context of this thesis. First, this data is used to show that MDE settings cover the whole spectrum concerning their impact on changeability or interrelation to software development processes. Neither it is seldom that MDE settings are neutral for processes nor is it seldom that MDE settings have impact on processes. Similarly, the impact on changeability differs relevantly. Second, a taxonomy of evolution of MDE settings is introduced. In that context it is discussed to what extent different types of changes on an MDE setting can influence this MDE setting's impact on changeability and the interrelation to processes. The category of structural evolution, which can change these characteristics of an MDE setting, is identified. The captured MDE settings from practice are used to show that structural evolution exists and is common. In addition, some examples of structural evolution steps are collected that actually led to a change in the characteristics of the respective MDE settings. Two implications are: First, the assessed diversity of MDE settings evaluates the need for the analysis techniques that shall be presented in this thesis. Second, evolution is one explanation for the diversity of MDE settings in practice. To summarize, this thesis studies the nature and evolution of MDE settings in practice. As a result support for the adoption of MDE settings is provided in form of techniques for the identification of risks relating to productivity impacts.}, language = {en} } @phdthesis{Kruegel2014, author = {Kr{\"u}gel, Andr{\´e}}, title = {Eye movement control during reading : factors and principles of computing the word center for saccade planning}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-72599}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {Reading is a complex cognitive task based on the analyses of visual stimuli. Due to the physiology of the eye, only a small number of letters around the fixation position can be extracted with high visual acuity, while the visibility of words and letters outside this so-called foveal region quickly drops with increasing eccentricity. As a consequence, saccadic eye movements are needed to repeatedly shift the fovea to new words for visual word identification during reading. Moreover, even within a foveated word fixation positions near the word center are superior to other fixation positions for efficient word recognition (O'Regan, 1981; Brysbaert, Vitu, and Schroyens, 1996). Thus, most reading theories assume that readers aim specifically at word centers during reading (for a review see Reichle, Rayner, \& Pollatsek, 2003). However, saccades' landing positions within words during reading are in fact systematically modulated by the distance of the launch site from the word center (McConkie, Kerr, Reddix, \& Zola, 1988). In general, it is largely unknown how readers identify the center of upcoming target words and there is no computational model of the sensorimotor translation of the decision for a target word into spatial word center coordinates. Here we present a series of three studies which aim at advancing the current knowledge about the computation of saccade target coordinates during saccade planning in reading. Based on a large corpus analyses, we firstly identified word skipping as a further factor beyond the launch-site distance with a likewise systematic and surprisingly large effect on within-word landing positions. Most importantly, we found that the end points of saccades after skipped word are shifted two and more letters to the left as compared to one-step saccades (i.e., from word N to word N+1) with equal launch-site distances. Then we present evidence from a single saccade experiment suggesting that the word-skipping effect results from highly automatic low-level perceptual processes, which are essentially based on the localization of blank spaces between words. Finally, in the third part, we present a Bayesian model of the computation of the word center from primary sensory measurements of inter-word spaces. We demonstrate that the model simultaneously accounts for launch-site and saccade-type contingent modulations of within-word landing positions in reading. Our results show that the spatial saccade target during reading is the result of complex estimations of the word center based on incomplete sensory information, which also leads to specific systematic deviations of saccades' landing positions from the word center. Our results have important implications for current reading models and experimental reading research.}, language = {en} } @phdthesis{Lotkowska2014, author = {Lotkowska, Magda Ewa}, title = {Functional analysis of MYB112 transcription factor in the model plant Arabidopsis thaliana}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-72131}, school = {Universit{\"a}t Potsdam}, year = {2014}, abstract = {Transcription factors (TFs) are ubiquitous gene expression regulators and play essential roles in almost all biological processes. This Ph.D. project is primarily focused on the functional characterisation of MYB112 - a member of the R2R3-MYB TF family from the model plant Arabidopsis thaliana. This gene was selected due to its increased expression during senescence based on previous qRT-PCR expression profiling experiments of 1880 TFs in Arabidopsis leaves at three developmental stages (15 mm leaf, 30 mm leaf and 20\% yellowing leaf). MYB112 promoter GUS fusion lines were generated to further investigate the expression pattern of MYB112. Employing transgenic approaches in combination with metabolomics and transcriptomics we demonstrate that MYB112 exerts a major role in regulation of plant flavonoid metabolism. We report enhanced and impaired anthocyanin accumulation in MYB112 overexpressors and MYB112-deficient mutants, respectively. Expression profiling reveals that MYB112 acts as a positive regulator of the transcription factor PAP1 leading to increased anthocyanin biosynthesis, and as a negative regulator of MYB12 and MYB111, which both control flavonol biosynthesis. We also identify MYB112 early responsive genes using a combination of several approaches. These include gene expression profiling (Affymetrix ATH1 micro-arrays and qRT-PCR) and transactivation assays in leaf mesophyll cell protoplasts. We show that MYB112 binds to an 8-bp DNA fragment containing the core sequence (A/T/G)(A/C)CC(A/T)(A/G/T)(A/C)(T/C). By electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation coupled to qPCR (ChIP-qPCR) we demonstrate that MYB112 binds in vitro and in vivo to MYB7 and MYB32 promoters revealing them as direct downstream target genes. MYB TFs were previously reported to play an important role in controlling flavonoid biosynthesis in plants. Many factors acting upstream of the anthocyanin biosynthesis pathway show enhanced expression levels during nitrogen limitation, or elevated sucrose content. In addition to the mentioned conditions, other environmental parameters including salinity or high light stress may trigger anthocyanin accumulation. In contrast to several other MYB TFs affecting anthocyanin biosynthesis pathway genes, MYB112 expression is not controlled by nitrogen limitation, or carbon excess, but rather is stimulated by salinity and high light stress. Thus, MYB112 constitutes a previously uncharacterised regulatory factor that modifies anthocyanin accumulation under conditions of abiotic stress.}, language = {en} }