@article{FuehrerSchlaad2014,
  author    = {Fuehrer, Felix N. and Schlaad, Helmut},
  title     = {ADMET polymerization of amino-acid-based diene},
  series = {Macromolecular chemistry and physics},
  volume    = {215},
  journal   = {Macromolecular chemistry and physics},
  number    = {22},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1022-1352},
  doi       = {10.1002/macp.201400166},
  pages     = {2268 -- 2273},
  year      = {2014},
  abstract  = {1,4-Di(homo)allyl-2,5-diketopiperazines are synthesized and polymerized via ADMET using the Hoveyda-Grubbs 2nd generation catalyst. The but-3-enylated diketopiperazine can be converted into unsaturated tertiary polyamide with molar mass of <3000 g mol(-1), whereas the allylated diketopiperazine cannot. Double-bond isomerization occurs regardless of whether or not benzoquinone is present. A polyesteramide with a higher molar mass of ca. 4800 g mol(-1) is obtained by the alternating copolymerization (ALTMET) of 1,4-di(but-3-enyl)-2,5-di ketopiperazine and ethylene glycol diacrylate. A post-polymerization modification of the poly(ester)amides via radical thiol-ene chemistry, however, fails.},
  language  = {en}
}
@article{SeckerRobinsonSchlaad2015,
  author    = {Secker, Christian and Robinson, Joshua W. and Schlaad, Helmut},
  title     = {Alkyne-X modification of polypeptoids},
  series = {European polymer journal},
  volume    = {62},
  journal   = {European polymer journal},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0014-3057},
  doi       = {10.1016/j.eurpolymj.2014.08.028},
  pages     = {394 -- 399},
  year      = {2015},
  abstract  = {Poly(N-propargyl glycine) (PNPG) can be readily prepared by ring-opening polymerization of N-propargyl glycine N-carboxyanhydride (NCA) and modified using various addition reactions such as copper catalyzed [3+2] cycloaddition of azide, radical (photo-)addition of thiol, nucleophilic addition of ethylene oxide, and thermal induced cross-linking. It is demonstrated that PNPG can serve as a modular platform to produce a bibliography of novel functional polypeptoid or pseudopeptide materials, including polypeptoid ionic liquids and graft copolymers.},
  language  = {en}
}
@article{HessSchmidtSchlaad2020,
  author    = {Hess, Andreas and Schmidt, Bernhard Volkmar Konrad Jakob and Schlaad, Helmut},
  title     = {Aminolysis induced functionalization of (RAFT) polymer-dithioester with thiols and disulfides},
  series = {Polymer Chemistry},
  volume    = {11},
  journal   = {Polymer Chemistry},
  number    = {48},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1759-9954},
  doi       = {10.1039/d0py01365j},
  pages     = {7677 -- 7684},
  year      = {2020},
  abstract  = {A series of polystyrene- and poly(methyl methacrylate)-dithioesters was subjected to aminolysis under ambient atmospheric conditions, i.e., in the presence of oxygen. Polymer disulfide coupling by oxidation occurred within tens of minutes and the yield of disulfide-coupled polymer increased with decreasing polymer molar mass. Oxidation of thiolates is usually an unwanted side reaction, here it is employed to obtain exclusively polymeric mixed disulfides through in situ aminolysis/functionalization in the presence of a thiol. The in situ aminolysis/functionalization in the presence of a disulfide, Ellman's reagent or polymer disulfide, resulted in the exclusive formation of polymer-dithionitrobenzoic acid, which can be further reacted with a thiol to exchange the terminal functionality, or block copolymer with dynamic disulfide linker, respectively.},
  language  = {en}
}
@article{GlatzelNoackSchanzenbachetal.2020,
  author    = {Glatzel, Julia and Noack, Sebastian and Schanzenbach, Dirk and Schlaad, Helmut},
  title     = {Anionic polymerization of dienes in 'green' solvents},
  series = {Polymer international},
  volume    = {70},
  journal   = {Polymer international},
  number    = {2},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0959-8103},
  doi       = {10.1002/pi.6152},
  pages     = {181 -- 184},
  year      = {2020},
  abstract  = {Isoprene and beta-myrcene were polymerized by anionic polymerization in bulk and in the 'green' ether solvents cyclopentyl methyl ether and 2-methyltetrahydrofuran and, for comparison, in cyclohexane and tetrahydrofuran. The polydienes produced in bulk and in cyclohexane contained high amounts of 1,4 units (>90\%) whereas those produced in ether solvents were rich in 1,2 and 3,4 units (36\%-86\%). Comparison of the microstructures and glass transition temperatures of the polydienes obtained in the various solvents suggests that conventionally used solvents can be substituted by environmentally more friendly alternatives.},
  language  = {en}
}
@article{SunCernochVoelkeletal.2016,
  author    = {Sun, Jing and Cernoch, Peter and V{\"o}lkel, Antje and Wei, Yuhan and Ruokolainen, Janne and Schlaad, Helmut},
  title     = {Aqueous Self-Assembly of a Protein-Mimetic Ampholytic Block Copolypeptide},
  series = {Macromolecules : a publication of the American Chemical Society},
  volume    = {49},
  journal   = {Macromolecules : a publication of the American Chemical Society},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {0024-9297},
  doi       = {10.1021/acs.macromol.6b00817},
  pages     = {5494 -- 5501},
  year      = {2016},
  abstract  = {This report describes the aggregation behavior of an ABC-type ampholytic block copolypeptide, poly(ethylene oxide)-block-poly(L-lysine)-block-poly(L-glutamate), in aqueous media in dependence of pH. Polypeptide secondary structures and self-assemblies are investigated by circular dichroism (CD), Fourier transform infrared (FT-IR) and NMR spectroscopy, zeta potential measurements, analytical ultracentrifugation (AUC), dynamic/static light scattering (DLS/SLS), and cryogenic transmission electron microscopy (cryoTEM). The polymer chains tend to form vesicles when the hydrophobic polypeptide helix is located at the chain end (acidic pH) and are existing as single chains when it is located in the center and flanked by the two hydrophilic segments (basic pH). Precipitation occurs in the intermediate pH range due to polyion complexation of the charged polypeptide segments.},
  language  = {en}
}
@article{BrosnanSchlaadAntonietti2015,
  author    = {Brosnan, Sarah M. and Schlaad, Helmut and Antonietti, Markus},
  title     = {Aqueous Self-Assembly of Purely Hydrophilic Block Copolymers into Giant Vesicles},
  series = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
  volume    = {54},
  journal   = {Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition},
  number    = {33},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1433-7851},
  doi       = {10.1002/anie.201502100},
  pages     = {9715 -- 9718},
  year      = {2015},
  abstract  = {Self-assembly of macromolecules is fundamental to life itself, and historically, these systems have been primitively mimicked by the development of amphiphilic systems, driven by the hydrophobic effect. Herein, we demonstrate that self-assembly of purely hydrophilic systems can be readily achieved with similar ease and success. We have synthesized double hydrophilic block copolymers from polysaccharides and poly(ethylene oxide) or poly(sarcosine) to yield high molar mass diblock copolymers through oxime chemistry. These hydrophilic materials can easily assemble into nanosized (<500nm) and microsized (>5m) polymeric vesicles depending on concentration and diblock composition. Because of the solely hydrophilic nature of these materials, we expect them to be extraordinarily water permeable systems that would be well suited for use as cellular mimics.},
  language  = {en}
}
@article{ChenSongZhaoetal.2018,
  author    = {Chen, Ye and Song, Qilei and Zhao, Junpeng and Gong, Xiangjun and Schlaad, Helmut and Zhang, Guangzhao},
  title     = {Betulin-Constituted multiblock amphiphiles for broad-spectrum protein resistance},
  series = {ACS applied materials \& interfaces},
  volume    = {10},
  journal   = {ACS applied materials \& interfaces},
  number    = {7},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1944-8244},
  doi       = {10.1021/acsami.7b16255},
  pages     = {6593 -- 6600},
  year      = {2018},
  abstract  = {Multiblock-like amphiphilic polyurethanes constituted by poly(ethylene oxide) and biosourced betulin are designed for antifouling and synthesized by a convenient organocatalytic route comprising tandem chain-growth and step-growth polymerizations. The doping density of betulin (D-B) in the polymer chain structure is readily varied by a mixed-initiator strategy. The spin-coated polymer films exhibit unique nanophase separation and protein resistance behaviors. Higher D-B leads to enhanced surface hydrophobicity and, unexpectedly, improved protein resistance. It is found that the surface holds molecular-level heterogeneity when D-B is substantially high due to restricted phase separation; therefore, broad-spectrum protein resistance is achieved despite considerable surface hydrophobicity. As D-B decreases, the distance between adjacent betulin units increases so that hydrophobic nanodomains are formed, which provide enough landing areas for relatively small-sized proteins to adsorb on the surface.},
  language  = {en}
}
@inproceedings{SchlaadLuedecke2019,
  author    = {Schlaad, Helmut and Luedecke, Nils},
  title     = {Bio-sourced chelating poly(2-oxazoline)s},
  series = {Abstracts of papers : joint conference / The Chemical Institute of Cananda, CIC, American Chemical Society, ACS},
  volume    = {257},
  booktitle = {Abstracts of papers : joint conference / The Chemical Institute of Cananda, CIC, American Chemical Society, ACS},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {0065-7727},
  pages     = {1},
  year      = {2019},
  language  = {en}
}
@misc{HardyTorresRendonLealEganaetal.2017,
  author    = {Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Ega{\~n}a, Aldo and Walther, Andreas and Schlaad, Helmut and C{\"o}lfen, Helmut and Scheibel, Thomas R.},
  title     = {Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-400519},
  pages     = {13},
  year      = {2017},
  abstract  = {Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.},
  language  = {en}
}
@article{HardyTorresRendonLealEganaetal.2016,
  author    = {Hardy, John G. and Torres-Rendon, Jose Guillermo and Leal-Egana, Aldo and Walther, Andreas and Schlaad, Helmut and Coelfen, Helmut and Scheibel, Thomas R.},
  title     = {Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering},
  series = {Materials},
  volume    = {9},
  journal   = {Materials},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1996-1944},
  doi       = {10.3390/ma9070560},
  pages     = {93 -- 108},
  year      = {2016},
  abstract  = {Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.},
  language  = {en}
}