@article{Friedlein2024, author = {Friedlein, Nicole}, title = {Promoting individual health tesponsibility in the welfare state}, series = {European journal of health law}, journal = {European journal of health law}, publisher = {Brill Nijhoff}, address = {Leiden}, issn = {1571-8093}, doi = {10.1163/15718093-bja10128}, pages = {1 -- 12}, year = {2024}, abstract = {The public health insurance in Germany will face huge economic challenges in the upcoming years. New diagnostic and therapeutic methods as well as the demographic change contribute to constantly rising expenditure. Although incentives for health-promoting behaviour or financial sanctions for an unhealthy lifestyle have been already discussed in the past, there has been a general reluctance to legally establish corresponding mechanisms for fear of eroding solidarity and increasing state control. In the course of the Coronavirus pandemic however, a stronger awareness rose to the fact that personal health-related life choices can have a huge impact on the stability of the healthcare system including public health insurance. Not only in Germany but throughout much of Europe, the pandemic led to a new and more fundamental debate about the relationship between individual responsibility for personal health and the wider responsibility for public health assumed by the community of solidarity.}, language = {en} } @phdthesis{Freimuth2024, author = {Freimuth, Nina}, title = {Elucidating the suppression of root hair formation by a member of a novel, short ENTH protein family in Arabidopsis thaliana}, doi = {10.25932/publishup-63499}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-634994}, school = {Universit{\"a}t Potsdam}, pages = {XIII, 156}, year = {2024}, abstract = {This work analyzed functional and regulatory aspects of the so far little characterized EPSIN N-terminal Homology (ENTH) domain-containing protein EPSINOID2 in Arabidopsis thaliana. ENTH domain proteins play accessory roles in the formation of clathrin-coated vesicles (CCVs) (Zouhar and Sauer 2014). Their ENTH domain interacts with membranes and their typically long, unstructured C-terminus contains binding motifs for adaptor protein complexes and clathrin itself. There are seven ENTH domain proteins in Arabidopsis. Four of them possess the canonical long C-terminus and participate in various, presumably CCV-related intracellular transport processes (Song et al. 2006; Lee et al. 2007; Sauer et al. 2013; Collins et al. 2020; Heinze et al. 2020; Mason et al. 2023). The remaining three ENTH domain proteins, however, have severely truncated C-termini and were termed EPSINOIDs (Zouhar and Sauer 2014; Freimuth 2015). Their functions are currently unclear. Preceding studies focusing on EPSINOID2 indicated a role in root hair formation: epsinoid2 T DNA mutants exhibited an increased root hair density and EPSINOID2-GFP was specifically located in non-hair cell files in the Arabidopsis root epidermis (Freimuth 2015, 2019). In this work, it was clearly shown that loss of EPSINOID2 leads to an increase in root hair density through analyses of three independent mutant alleles, including a newly generated CRISPR/Cas9 full deletion mutant. The ectopic root hairs emerging from non-hair positions in all epsinoid2 mutant alleles are most likely not a consequence of altered cell fate, because extensive genetic analyses placed EPSINOID2 downstream of the established epidermal patterning network. Thus, EPSINOID2 seems to act as a cell autonomous inhibitor of root hair formation. Attempts to confirm this hypothesis by ectopically overexpressing EPSINOID2 led to the discovery of post-transcriptional and -translational regulation through different mechanisms. One involves the little characterized miRNA844-3p. Interference with this pathway resulted in ectopic EPSINOID2 overexpression and decreased root hair density, confirming it as negative factor in root hair formation. A second mechanism likely involves proteasomal degradation. Treatment with proteasomal inhibitor MG132 led to EPSINOID2-GFP accumulation, and a KEN box degron motif was identified in the EPSINOID2 sequence associated with degradation through a ubiquitin/proteasome-dependent pathway. In line with a tight dose regulation, genetic analyses of all three mutant alleles indicate that EPSINOID2 is haploinsufficient. Lastly, it was revealed that, although EPSINOID2 promoter activity was found in all epidermal cells, protein accumulation was observed in N-cells only, hinting at yet another layer of regulation.}, language = {en} } @article{FranzkeKuhlmannPeters2024, author = {Franzke, Jochen and Kuhlmann, Sabine and Peters, Niklas}, title = {Krisen-Governance im europ{\"a}ischen Vergleich}, series = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)}, journal = {Kommunalwissenschaften an der Universit{\"a}t Potsdam (KWI-Schriften ; 15)}, number = {15}, editor = {Schmidt, Thorsten Ingo and Bickenbach, Christian and Gronewold, Ulfert and Kuhlmann, Sabine and Ulrich, Peter}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-581-1}, issn = {1867-951X}, doi = {10.25932/publishup-64784}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-647843}, pages = {59 -- 71}, year = {2024}, language = {de} } @book{Franz2024, author = {Franz, Norbert P.}, title = {Der russische Krimi}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-549-1}, doi = {10.25932/publishup-61559}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-615591}, publisher = {Universit{\"a}t Potsdam}, pages = {506}, year = {2024}, abstract = {Die erste umfassende Darstellung des Kriminalgenres in Russland. Sie geht auf B{\"u}cher und Filme ein und ber{\"u}cksichtigt die Debatten der Literaturkritik, da sich die Kulturpolitik w{\"a}hrend der sowjetischen Jahrzehnte schwer damit tat, dem Kriminalgenre {\"u}berhaupt ein Existenzrecht zubilligen. Sympathie f{\"u}r die Miliz zu erzeugen wurde schließlich offizieller Zweck dieses politisch zu einer Nischenexistenz gedr{\"a}ngten Genres. Entsprechend liegt ein Akzent der Studie auf der Ideologie, besonders bei der Darstellung der Helden und ihrer Gegner und der Lebenswelt, die die Leser als ihre wiedererkennen sollten. Dabei erfahren sie eine Menge {\"u}ber die Gesellschaft, vor allem {\"u}ber deren sonst eher verschwiegene Schattenseiten. Nicht zuletzt wegen der langen Entbehrung spannender Texte wurde der Krimi nach dem Ende des Sozialismus zu dem Bestsellergenre schlechthin. Am Beispiel des Frauenkrimis (Marinina und Nachfolgerinnen) und des postmodernen Krimis (Akunin) wird die postsowjetische Entwicklung bis in die 2010er Jahre gezeigt.}, language = {de} } @phdthesis{Franke2024, author = {Franke, Vanessa}, title = {Die Entwicklung des Verantwortungseigentums anhand der Carl-Zeiss-Stiftung unter Ernst Abbe}, series = {Europ{\"a}ische Hochschulschriften Recht}, volume = {6798}, journal = {Europ{\"a}ische Hochschulschriften Recht}, publisher = {Peter Lang}, address = {Berlin}, isbn = {978-3-631-92255-2}, issn = {0531-7312}, doi = {10.3726/b22044}, school = {Universit{\"a}t Potsdam}, pages = {238}, year = {2024}, abstract = {Die Dissertation untersucht die Entwicklung des Verantwortungseigentums insbesondere anhand der Carl-Zeiss-Stiftung unter Ernst Abbe. Der Begriff des Verantwortungseigentums wird seit einigen Jahren in der rechtspolitischen Debatte zu alternativen Unternehmens- und Eigentumsformen diskutiert. Dabei wird die Einf{\"u}hrung einer eigenen Gesellschaftsform gefordert. Die Dissertation widmet sich diesen Forderungen und den Entwicklungen des Verantwortungseigentums anhand der Carl-Zeiss-Stiftung und ihrer Stiftungsbetriebe Zeiss und Schott. Dort wurde bereits Ende des 19. Jahrhunderts eine Form dessen, was Jurist:innen heute unter Verantwortungseigentum verstehen, kautelar-juristisch eingef{\"u}hrt und gepr{\"a}gt. Ziel und Zweck der Arbeit war es, die {\"U}berschneidungen, Parallelen und Unterschiede der Rechtssubjekte zu untersuchen und der Frage auf den Grund zu gehen, ob das Verantwortungseigentum einer l{\"a}ngeren Rechtstradition folgt oder eine rein zeitgen{\"o}ssische Idee ist.}, language = {de} } @phdthesis{Frank2024, author = {Frank, Mario}, title = {On synthesising Linux kernel module components from Coq formalisations}, doi = {10.25932/publishup-64255}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-642558}, school = {Universit{\"a}t Potsdam}, pages = {IX, 78}, year = {2024}, abstract = {This thesis presents an attempt to use source code synthesised from Coq formalisations of device drivers for existing (micro)kernel operating systems, with a particular focus on the Linux Kernel. In the first part, the technical background and related work are described. The focus is here on the possible approaches to synthesising certified software with Coq, namely the extraction to functional languages using the Coq extraction plugin and the extraction to Clight code using the CertiCoq plugin. It is noted that the implementation of CertiCoq is verified, whereas this is not the case for the Coq extraction plugin. Consequently, there is a correctness guarantee for the generated Clight code which does not hold for the code being generated by the Coq extraction plugin. Furthermore, the differences between user space and kernel space software are discussed in relation to Linux device drivers. It is elaborated that it is not possible to generate working Linux kernel module components using the Coq extraction plugin without significant modifications. In contrast, it is possible to produce working user space drivers both with the Coq extraction plugin and CertiCoq. The subsequent parts describe the main contributions of the thesis. In the second part, it is demonstrated how to extend the Coq extraction plugin to synthesise foreign function calls between the functional language OCaml and the imperative language C. This approach has the potential to improve the type-safety of user space drivers. Furthermore, it is shown that the code being synthesised by CertiCoq cannot be used in kernel space without modifications to the necessary runtime. Consequently, the necessary modifications to the runtimes of CertiCoq and VeriFFI are introduced, resulting in the runtimes becoming compatible components of a Linux kernel module. Furthermore, justifications for the transformations are provided and possible further extensions to both plugins and solutions to failing garbage collection calls in kernel space are discussed. The third part presents a proof of concept device driver for the Linux Kernel. To achieve this, the event handler of the original PC Speaker driver is partially formalised in Coq. Furthermore, some relevant formal properties of the formalised functionality are discussed. Subsequently, a kernel module is defined, utilising the modified variants of CertiCoq and VeriFFI to compile a working device driver. It is furthermore shown that it is possible to compile the synthesised code with CompCert, thereby extending the guarantee of correctness to the assembly layer. This is followed by a performance evaluation that compares a naive formalisation of the PC speaker functionality with the original PC Speaker driver pointing out the weaknesses in the formalisation and possible improvements. The part closes with a summary of the results, their implications and open questions being raised. The last part lists all used sources, separated into scientific literature, documentations or reference manuals and artifacts, i.e. source code.}, language = {en} } @article{FleischerDanielsenNebyetal.2024, author = {Fleischer, Julia and Danielsen, Ole A. and Neby, Simon and Nykvist, Rasmus}, title = {The state as a marketizer vs. the marketization of the state}, series = {Public organization review : a global journal}, journal = {Public organization review : a global journal}, publisher = {Springer Science + Business Media B.V.}, address = {Dordrecht}, issn = {1566-7170}, doi = {10.1007/s11115-024-00769-x}, pages = {16}, year = {2024}, abstract = {Governments engage in corporatization by creating corporate entities or reorganizing existing ones. These corporatization activities reflect an interplay between political agency and environmental pressures, including (changing) notions of state-market relations. This paper discusses two ideal-typed organizational models of corporatization: the state as a marketizer and the marketization of the state. Whereas the first emphasizes the role of political design and agency in corporatization, the second emphasizes the role of (actors in) the environment for corporatization. Both models are assessed across five corporatization episodes in Norway and Sweden, where we also demonstrate the interplay between political agency and environmental pressure.}, language = {en} } @phdthesis{Fitzner2024, author = {Fitzner, Maria}, title = {Cultivation of selected halophytes in saline indoor farming and modulation of cultivation conditions to optimize metabolite profiles for human nutrition}, doi = {10.25932/publishup-62697}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-626974}, school = {Universit{\"a}t Potsdam}, pages = {178}, year = {2024}, abstract = {With the many challenges facing the agricultural system, such as water scarcity, loss of arable land due to climate change, population growth, urbanization or trade disruptions, new agri-food systems are needed to ensure food security in the future. In addition, healthy diets are needed to combat non-communicable diseases. Therefore, plant-based diets rich in health-promoting plant secondary metabolites are desirable. A saline indoor farming system is representing a sustainable and resilient new agrifood system and can preserve valuable fresh water. Since indoor farming relies on artificial lighting, assessment of lighting conditions is essential. In this thesis, the cultivation of halophytes in a saline indoor farming system was evaluated and the influence of cultivation conditions were assessed in favor of improving the nutritional quality of halophytes for human consumption. Therefore, five selected edible halophyte species (Brassica oleracea var. palmifolia, Cochlearia officinalis, Atriplex hortensis, Chenopodium quinoa, and Salicornia europaea) were cultivated in saline indoor farming. The halophyte species were selected for to their salt tolerance levels and mechanisms. First, the suitability of halophytes for saline indoor farming and the influence of salinity on their nutritional properties, e.g. plant secondary metabolites and minerals, were investigated. Changes in plant performance and nutritional properties were observed as a function of salinity. The response to salinity was found to be species-specific and related to the salt tolerance mechanism of the halophytes. At their optimal salinity levels, the halophytes showed improved carotenoid content. In addition, a negative correlation was found between the nitrate and chloride content of halophytes as a function of salinity. Since chloride and nitrate can be antinutrient compounds, depending on their content, monitoring is essential, especially in halophytes. Second, regional brine water was introduced as an alternative saline water resource in the saline indoor farming system. Brine water was shown to be feasible for saline indoor farming of halophytes, as there was no adverse effect on growth or nutritional properties, e.g. carotenoids. Carotenoids were shown to be less affected by salt composition than by salt concentration. In addition, the interaction between the salinity and the light regime in indoor farming and greenhouse cultivation has been studied. There it was shown that interacting light regime and salinity alters the content of carotenoids and chlorophylls. Further, glucosinolate and nitrate content were also shown to be influenced by light regime. Finally, the influence of UVB light on halophytes was investigated using supplemental narrow-band UVB LEDs. It was shown that UVB light affects the growth, phenotype and metabolite profile of halophytes and that the UVB response is species specific. Furthermore, a modulation of carotenoid content in S. europaea could be achieved to enhance health-promoting properties and thus improve nutritional quality. This was shown to be dose-dependent and the underlying mechanisms of carotenoid accumulation were also investigated. Here it was revealed that carotenoid accumulation is related to oxidative stress. In conclusion, this work demonstrated the potential of halophytes as alternative vegetables produced in a saline indoor farming system for future diets that could contribute to ensuring food security in the future. To improve the sustainability of the saline indoor farming system, LED lamps and regional brine water could be integrated into the system. Since the nutritional properties have been shown to be influenced by salt, light regime and UVB light, these abiotic stressors must be taken into account when considering halophytes as alternative vegetables for human nutrition.}, language = {en} } @phdthesis{Felisatti2024, author = {Felisatti, Arianna}, title = {Spatial-numerical associations: From biological foundations to embodied learning to contextual flexibility}, doi = {10.25932/publishup-64179}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-641791}, school = {Universit{\"a}t Potsdam}, pages = {x, 195}, year = {2024}, abstract = {Among the different meanings carried by numerical information, cardinality is fundamental for survival and for the development of basic as well as of higher numerical skills. Importantly, the human brain inherits from evolution a predisposition to map cardinality onto space, as revealed by the presence of spatial-numerical associations (SNAs) in humans and animals. Here, the mapping of cardinal information onto physical space is addressed as a hallmark signature characterizing numerical cognition. According to traditional approaches, cognition is defined as complex forms of internal information processing, taking place in the brain (cognitive processor). On the contrary, embodied cognition approaches define cognition as functionally linked to perception and action, in the continuous interaction between a biological body and its physical and sociocultural environment. Embracing the principles of the embodied cognition perspective, I conducted four novel studies designed to unveil how SNAs originate, develop, and adapt, depending on characteristics of the organism, the context, and their interaction. I structured my doctoral thesis in three levels. At the grounded level (Study 1), I unfold the biological foundations underlying the tendency to map cardinal information across space; at the embodied level (Study 2), I reveal the impact of atypical motor development on the construction of SNAs; at the situated level (Study 3), I document the joint influence of visuospatial attention and task properties on SNAs. Furthermore, I experimentally investigate the presence of associations between physical and numerical distance, another numerical property fundamental for the development of efficient mathematical minds (Study 4). In Study 1, I present the Brain's Asymmetric Frequency Tuning hypothesis that relies on hemispheric asymmetries for processing spatial frequencies, a low-level visual feature that the (in)vertebrate brain extracts from any visual scene to create a coherent percept of the world. Computational analyses of the power spectra of the original stimuli used to document the presence of SNAs in human newborns and animals, support the brain's asymmetric frequency tuning as a theoretical account and as an evolutionarily inherited mechanism scaffolding the universal and innate tendency to represent cardinality across horizontal space. In Study 2, I explore SNAs in children with rare genetic neuromuscular diseases: spinal muscular atrophy (SMA) and Duchenne muscular dystrophy (DMD). SMA children never accomplish independent motoric exploration of their environment; in contrast, DMD children do explore but later lose this ability. The different SNAs reported by the two groups support the critical role of early sensorimotor experiences in the spatial representation of cardinality. In Study 3, I directly compare the effects of overt attentional orientation during explicit and implicit processing of numerical magnitude. First, the different effects of attentional orienting based on the type of assessment support different mechanisms underlying SNAs during explicit and implicit assessment of numerical magnitude. Secondly, the impact of vertical shifts of attention on the processing of numerical distance sheds light on the correspondence between numerical distance and peri-personal distance. In Study 4, I document the presence of different SNAs, driven by numerical magnitude and numerical distance, by employing different response mappings (left vs. right and near vs. distant). In the field of numerical cognition, the four studies included in the present thesis contribute to unveiling how the characteristics of the organism and the environment influence the emergence, the development, and the flexibility of our attitude to represent cardinal information across space, thus supporting the predictions of the embodied cognition approach. Furthermore, they inform a taxonomy of body-centred factors (biological properties of the brain and sensorimotor system) modulating the spatial representation of cardinality throughout the course of life, at the grounded, embodied, and situated levels. If the awareness for different variables influencing SNAs over the course of life is important, it is equally important to consider the organism as a whole in its sensorimotor interaction with the world. Inspired by my doctoral research, here I propose a holistic perspective that considers the role of evolution, embodiment, and environment in the association of cardinal information with directional space. The new perspective advances the current approaches to SNAs, both at the conceptual and at the methodological levels. Unveiling how the mental representation of cardinality emerges, develops, and adapts is necessary to shape efficient mathematical minds and achieve economic productivity, technological progress, and a higher quality of life.}, language = {en} } @misc{EtteSchwarzGaoetal.2024, author = {Ette, Ottmar and Schwarz, Ingo and Gao, Hong and Kraft, Tobias and Kutzinski, Vera and Zielnica, Krzysztof}, title = {HiN : Alexander von Humboldt im Netz}, volume = {XXV}, number = {48}, editor = {Ette, Ottmar and Knobloch, Eberhard}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {2568-3543}, doi = {10.18443/hinvol25iss482024}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-633524}, pages = {100}, year = {2024}, abstract = {-Ottmar Ette, Ingo Schwarz: „Ein junges, neues Geschlecht wird besseres liefern als das alte". Ein Empfehlungsbrief Alexander von Humboldts f{\"u}r Carl Ludwig -GAO Hong: Nachgedanken zur {\"U}bersetzung des ersten Bandes von Humboldts Kosmos -Tobias Kraft: Neue Quellen zu Humboldts Kuba-Forschung. Das „Digitale Dossier" des Proyecto Humboldt Digital (2019 - 2023) -Vera Kutzinski: Off-Road Adventures: Reading Statistics in Alexander von Humboldt's Political Essay on the Kingdom of New Spain -Krzysztof Zielnica: Alexander von Humboldt und Polen - zum 150. Jahrestag seiner Reise nach Warschau. Mit einleitenden Worten von Ingo Schwarz}, language = {de} }