@misc{ZouharSauer2014, author = {Zouhar, Jan and Sauer, Michael}, title = {Helping hands for budding prospects: ENTH/ANTH/VHS accessory proteins in endocytosis, vacuolar transport, and secretion}, series = {The plant cell}, volume = {26}, journal = {The plant cell}, number = {11}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {1040-4651}, doi = {10.1105/tpc.114.131680}, pages = {4232 -- 4244}, year = {2014}, abstract = {Coated vesicles provide a major mechanism for the transport of proteins through the endomembrane system of plants. Transport between the endoplasmic reticulum and the Golgi involves vesicles with COPI and COPII coats, whereas clathrin is the predominant coat in endocytosis and post-Golgi trafficking. Sorting of cargo, coat assembly, budding, and fission are all complex and tightly regulated processes that involve many proteins. The mechanisms and responsible factors are largely conserved in eukaryotes, and increasing organismal complexity tends to be associated with a greater numbers of individual family members. Among the key factors is the class of ENTH/ANTH/VHS domain-containing proteins, which link membrane subdomains, clathrin, and other adapter proteins involved in early steps of clathrin coated vesicle formation. More than 30 Arabidopsis thaliana proteins contain this domain, but their generally low sequence conservation has made functional classification difficult. Reports from the last two years have greatly expanded our knowledge of these proteins and suggest that ENTH/ANTH/VHS domain proteins are involved in various instances of clathrin-related endomembrane trafficking in plants. This review aims to summarize these new findings and discuss the broader context of clathrin-dependent plant vesicular transport.}, language = {en} } @misc{Wyrwa2014, author = {Wyrwa, Ulrich}, title = {Heinrich von Treitschke. Effect and perception of a historian in the 19th and 20th centuries}, series = {Deutsche Zeitschrift f{\"u}r Geschichtswissenschaft}, volume = {62}, journal = {Deutsche Zeitschrift f{\"u}r Geschichtswissenschaft}, number = {12}, publisher = {Metropol-Verl.}, address = {Berlin}, issn = {0044-2828}, pages = {1033 -- 1035}, year = {2014}, language = {de} } @misc{WinklerCherstvy2014, author = {Winkler, Roland G. and Cherstvy, Andrey G.}, title = {Strong and weak polyelectrolyte adsorption onto oppositely charged curved surfaces}, series = {Advances in polymer science}, volume = {255}, journal = {Advances in polymer science}, editor = {Muller, M.}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-40734-5; 978-3-642-40733-8}, issn = {0065-3195}, doi = {10.1007/12_2012_183}, pages = {1 -- 56}, year = {2014}, abstract = {Polyelectrolytes are macromolecules composed of charged monomers and exhibit unique properties due to the interplay of their flexibility and electrostatic interactions. In solution, they are attracted to oppositely charged surfaces and interfaces and exhibit a transition to an adsorbed state when certain conditions are met concerning the charge densities of the polymer and surface and the properties of the solution. In this review, we discuss two limiting cases for adsorption of flexible polyelectrolytes on curved surfaces: weak and strong adsorption. In the first case, adsorption is strongly influenced by the entropic degrees of freedom of a flexible polyelectrolyte. By contrast, in the strong adsorption limit, electrostatic interactions dominate, which leads to particular adsorption patterns, specifically on spherical surfaces. We discuss the corresponding theoretical approaches, applying a mean-field description for the polymer and the polymer-surface interaction. For weak adsorption, we discuss the critical adsorption behavior by exactly solvable models for planar and spherical geometries and a generic approximation scheme, which is additionally applied to cylindrical surfaces. For strong adsorption, we investigate various polyelectrolyte patterns on cylinders and spheres and evaluate their stability. The results are discussed in the light of experimental results, mostly of DNA adsorption experiments.}, language = {en} } @misc{Wiemann2014, author = {Wiemann, Dirk}, title = {George, Rosemary Marangoly, Indian English and the Fiction of National Literature / [rezensiert von] Dirk Wiemann}, series = {Zeitschrift f{\"u}r Anglistik und Amerikanistik : ZAA ; a quarterly of language, literature and culture}, volume = {62}, journal = {Zeitschrift f{\"u}r Anglistik und Amerikanistik : ZAA ; a quarterly of language, literature and culture}, number = {4}, publisher = {DeGruyter}, address = {T{\"u}bingen}, issn = {0044-2305}, doi = {10.1515/zaa-2014-0039}, pages = {385 -- 388}, year = {2014}, abstract = {Rezensiertes Werk George, Rosemary Marangoly, Indian English and the Fiction of National Literature - Cambridge: Cambridge University Press, 2013. - Hb. viii, 285 pp. - (Zeitschrift f{\"u}r Anglistik und Amerikanistik ; 62(4)) ISBN 978-1-107-04000-7.}, language = {en} } @misc{Widdau2014, author = {Widdau, Christoph Sebastian}, title = {Sprengler, O., Der Untergang des Abendslandes Umrisse einer Morphologie der Weltgeschichte; Manheim, Albatros, 2011}, year = {2014}, language = {de} } @misc{vonWebskyReichetzederHocher2014, author = {von Websky, Karoline and Reichetzeder, Christoph and Hocher, Berthold}, title = {Physiology and pathophysiology of incretins in the kidney}, series = {Current opinion in nephrology and hypertension : reviews of all advances, evaluations of key references, comprehensive listing of papers}, volume = {23}, journal = {Current opinion in nephrology and hypertension : reviews of all advances, evaluations of key references, comprehensive listing of papers}, number = {1}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {1062-4821}, doi = {10.1097/01.mnh.0000437542.77175.a0}, pages = {54 -- 60}, year = {2014}, abstract = {Purpose of reviewIncretin-based therapy with glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors is considered a promising therapeutic option for type 2 diabetes mellitus. Cumulative evidence, mainly from preclinical animal studies, reveals that incretin-based therapies also may elicit beneficial effects on kidney function. This review gives an overview of the physiology, pathophysiology, and pharmacology of the renal incretin system.Recent findingsActivation of GLP-1R in the kidney leads to diuretic and natriuretic effects, possibly through direct actions on renal tubular cells and sodium transporters. Moreover, there is evidence that incretin-based therapy reduces albuminuria, glomerulosclerosis, oxidative stress, and fibrosis in the kidney, partially through GLP-1R-independent pathways. Molecular mechanisms by which incretins exert their renal effects are understood incompletely, thus further studies are needed.SummaryThe GLP-1R and DPP-4 are expressed in the kidney in various species. The kidney plays an important role in the excretion of incretin metabolites and most GLP-1R agonists and DPP-4 inhibitors, thus special attention is required when applying incretin-based therapy in renal impairment. Preclinical observations suggest direct renoprotective effects of incretin-based therapies in the setting of hypertension and other disorders of sodium retention, as well as in diabetic and nondiabetic nephropathy. Clinical studies are needed in order to confirm translational relevance from preclinical findings for treatment options of renal diseases.}, language = {en} } @misc{UnuabonahTaubert2014, author = {Unuabonah, Emmanuel I. and Taubert, Andreas}, title = {Clay-polymer nanocomposites (CPNs): Adsorbents of the future for water treatment}, series = {Applied clay science : an international journal on the application and technology of clays and clay minerals}, volume = {99}, journal = {Applied clay science : an international journal on the application and technology of clays and clay minerals}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0169-1317}, doi = {10.1016/j.clay.2014.06.016}, pages = {83 -- 92}, year = {2014}, abstract = {A class of adsorbents currently receiving growing attention is the clay-polymer nanocomposite (CPN) adsorbents. CPNs effectively treat water by adsorption and flocculation of both inorganic and organic micropollutants from aqueous solutions. Some of these CPNs - when modified with biocides - also have the ability to efficiently remove microorganisms such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans from water. CPNs are far more easily recovered from aqueous media than neat clay. They also exhibit far better treatment times than either polymer or clay adsorbents. They have higher adsorption capacity and better life cycles compared with clay alone. CPNs therefore show an excellent potential as highly efficient water and waste treatment agents. This article reviews the various CPNs that have been prepared recently and used as adsorbents in the removal of micropollutants (inorganic, organic and biological) from aqueous solutions. A special focus is placed on CPNs that are not only interesting from an academic point of view but also effectively reduce the concentration of micropollutants in water to safe limits and also on new developments bordering on CPN use as water treatment agent that have not yet realized their full potential. (C) 2014 Elsevier B.V. All rights reserved.}, language = {en} } @misc{UestuenBoernke2014, author = {Uestuen, Suayib and Boernke, Frederik}, title = {Interactions of Xanthomonas type-III effector proteins with the plant ubiquitin and ubiquitin-like pathways}, series = {Frontiers in plant science}, volume = {5}, journal = {Frontiers in plant science}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-462X}, doi = {10.3389/fpls.2014.00736}, pages = {6}, year = {2014}, abstract = {In eukaryotes, regulated protein turnover is required during many cellular processes, including defense against pathogens. Ubiquitination and degradation of ubiquitinated proteins via the ubiquitin proteasome system (UPS) is the main pathway for the turnover of intracellular proteins in eukaryotes. The extensive utilization of the UPS in host cells makes it an ideal pivot for the manipulation of cellular processes by pathogens. Like many other Gram-negative bacteria, Xanthomonas species secrete a suite of type-III effector proteins (T3Es) into their host cells to promote virulence. Some of these T3Es exploit the plant UPS to interfere with immunity. This review summarizes T3E examples from the genus Xanthomonas with a proven or suggested interaction with the host UPS or UPS-like systems and also discusses the apparent paradox that arises from the presence of T3Es that inhibit the UPS in general while others rely on its activity for their function.}, language = {en} } @misc{TrukenbrodEngbert2014, author = {Trukenbrod, Hans Arne and Engbert, Ralf}, title = {ICAT: a computational model for the adaptive control of fixation durations}, series = {Psychonomic bulletin \& review : a journal of the Psychonomic Society}, volume = {21}, journal = {Psychonomic bulletin \& review : a journal of the Psychonomic Society}, number = {4}, publisher = {Springer}, address = {New York}, issn = {1069-9384}, doi = {10.3758/s13423-013-0575-0}, pages = {907 -- 934}, year = {2014}, abstract = {Eye movements depend on cognitive processes related to visual information processing. Much has been learned about the spatial selection of fixation locations, while the principles governing the temporal control (fixation durations) are less clear. Here, we review current theories for the control of fixation durations in tasks like visual search, scanning, scene perception, and reading and propose a new model for the control of fixation durations. We distinguish two local principles from one global principle of control. First, an autonomous saccade timer initiates saccades after random time intervals (local-I). Second, foveal inhibition permits immediate prolongation of fixation durations by ongoing processing (local-II). Third, saccade timing is adaptive, so that the mean timer value depends on task requirements and fixation history (Global). We demonstrate by numerical simulations that our model qualitatively reproduces patterns of mean fixation durations and fixation duration distributions observed in typical experiments. When combined with assumptions of saccade target selection and oculomotor control, the model accounts for both temporal and spatial aspects of eye movement control in two versions of a visual search task. We conclude that the model provides a promising framework for the control of fixation durations in saccadic tasks.}, language = {en} } @misc{TroppmannBalfanzKrachetal.2014, author = {Troppmann, Britta and Balfanz, Sabine and Krach, Christian and Baumann, Arnd and Blenau, Wolfgang}, title = {Characterization of an Invertebrate-Type Dopamine Receptor of the American Cockroach, Periplaneta americana}, series = {International journal of molecular sciences}, volume = {15}, journal = {International journal of molecular sciences}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1422-0067}, doi = {10.3390/ijms15010629}, pages = {629 -- 653}, year = {2014}, abstract = {We have isolated a cDNA coding for a putative invertebrate-type dopamine receptor (Peadop2) from P. americana brain by using a PCR-based strategy. The mRNA is present in samples from brain and salivary glands. We analyzed the distribution of the PeaDOP2 receptor protein with specific affinity-purified polyclonal antibodies. On Western blots, PeaDOP2 was detected in protein samples from brain, subesophageal ganglion, thoracic ganglia, and salivary glands. In immunocytochemical experiments, we detected PeaDOP2 in neurons with their somata being located at the anterior edge of the medulla bilaterally innervating the optic lobes and projecting to the ventro-lateral protocerebrum. In order to determine the functional and pharmacological properties of the cloned receptor, we generated a cell line constitutively expressing PeaDOP2. Activation of PeaDOP2-expressing cells with dopamine induced an increase in intracellular cAMP. In contrast, a C-terminally truncated splice variant of this receptor did not exhibit any functional property by itself. The molecular and pharmacological characterization of the first dopamine receptor from P. americana provides the basis for forthcoming studies focusing on the significance of the dopaminergic system in cockroach behavior and physiology.}, language = {en} }