@misc{SchieferdeckerWendler2019, author = {Schieferdecker, Anne and Wendler, Petra}, title = {Structural mapping of missense mutations in the Pex1/Pex6 complex}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1072}, issn = {1866-8372}, doi = {10.25932/publishup-47284}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472843}, pages = {27}, year = {2019}, abstract = {Peroxisome biogenesis disorders (PBDs) are nontreatable hereditary diseases with a broad range of severity. Approximately 65\% of patients are affected by mutations in the peroxins Pex1 and Pex6. The proteins form the heteromeric Pex1/Pex6 complex, which is important for protein import into peroxisomes. To date, no structural data are available for this AAA+ ATPase complex. However, a wealth of information can be transferred from low-resolution structures of the yeast scPex1/scPex6 complex and homologous, well-characterized AAA+ ATPases. We review the abundant records of missense mutations described in PBD patients with the aim to classify and rationalize them by mapping them onto a homology model of the human Pex1/Pex6 complex. Several mutations concern functionally conserved residues that are implied in ATP hydrolysis and substrate processing. Contrary to fold destabilizing mutations, patients suffering from function-impairing mutations may not benefit from stabilizing agents, which have been reported as potential therapeutics for PBD patients.}, language = {en} } @misc{AyzelIzhitskiy2019, author = {Ayzel, Georgy and Izhitskiy, Alexander}, title = {Climate change impact assessment on freshwater inflow into the Small Aral Sea}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1071}, issn = {1866-8372}, doi = {10.25932/publishup-47279}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472794}, pages = {21}, year = {2019}, abstract = {During the last few decades, the rapid separation of the Small Aral Sea from the isolated basin has changed its hydrological and ecological conditions tremendously. In the present study, we developed and validated the hybrid model for the Syr Darya River basin based on a combination of state-of-the-art hydrological and machine learning models. Climate change impact on freshwater inflow into the Small Aral Sea for the projection period 2007-2099 has been quantified based on the developed hybrid model and bias corrected and downscaled meteorological projections simulated by four General Circulation Models (GCM) for each of three Representative Concentration Pathway scenarios (RCP). The developed hybrid model reliably simulates freshwater inflow for the historical period with a Nash-Sutcliffe efficiency of 0.72 and a Kling-Gupta efficiency of 0.77. Results of the climate change impact assessment showed that the freshwater inflow projections produced by different GCMs are misleading by providing contradictory results for the projection period. However, we identified that the relative runoff changes are expected to be more pronounced in the case of more aggressive RCP scenarios. The simulated projections of freshwater inflow provide a basis for further assessment of climate change impacts on hydrological and ecological conditions of the Small Aral Sea in the 21st Century.}, language = {en} } @misc{ChaabenePrieskeLesinskietal.2019, author = {Chaabene, Helmi and Prieske, Olaf and Lesinski, Melanie and Sandau, Ingo and Granacher, Urs}, title = {Short-term seasonal development of anthropometry, body composition, physical fitness, and sport-specific performance in young olympic weightlifters}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {685}, issn = {1866-8364}, doi = {10.25932/publishup-47260}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472609}, pages = {15}, year = {2019}, abstract = {The aim of this study is to monitor short-term seasonal development of young Olympic weightlifters' anthropometry, body composition, physical fitness, and sport-specific performance. Fifteen male weightlifters aged 13.2 ± 1.3 years participated in this study. Tests for the assessment of anthropometry (e.g., body-height, body-mass), body-composition (e.g., lean-body-mass, relative fat-mass), muscle strength (grip-strength), jump performance (drop-jump (DJ) height, countermovement-jump (CMJ) height, DJ contact time, DJ reactive-strength-index (RSI)), dynamic balance (Y-balance-test), and sport-specific performance (i.e., snatch and clean-and-jerk) were conducted at different time-points (i.e., T1 (baseline), T2 (9 weeks), T3 (20 weeks)). Strength tests (i.e., grip strength, clean-and-jerk and snatch) and training volume were normalized to body mass. Results showed small-to-large increases in body-height, body-mass, lean-body-mass, and lower-limbs lean-mass from T1-to-T2 and T2-to-T3 (∆0.7-6.7\%; 0.1 ≤ d ≤ 1.2). For fat-mass, a significant small-sized decrease was found from T1-to-T2 (∆13.1\%; d = 0.4) and a significant increase from T2-to-T3 (∆9.1\%; d = 0.3). A significant main effect of time was observed for DJ contact time (d = 1.3) with a trend toward a significant decrease from T1-to-T2 (∆-15.3\%; d = 0.66; p = 0.06). For RSI, significant small increases from T1-to-T2 (∆9.9\%, d = 0.5) were noted. Additionally, a significant main effect of time was found for snatch (d = 2.7) and clean-and-jerk (d = 3.1) with significant small-to-moderate increases for both tests from T1-to-T2 and T2-to-T3 (∆4.6-11.3\%, d = 0.33 to 0.64). The other tests did not change significantly over time (0.1 ≤ d ≤ 0.8). Results showed significantly higher training volume for sport-specific training during the second period compared with the first period (d = 2.2). Five months of Olympic weightlifting contributed to significant changes in anthropometry, body-composition, and sport-specific performance. However, hardly any significant gains were observed for measures of physical fitness. Coaches are advised to design training programs that target a variety of fitness components to lay an appropriate foundation for later performance as an elite athlete.}, language = {en} } @misc{HoehleBijeljacBabicNazzi2019, author = {H{\"o}hle, Barbara and Bijeljac-Babic, Ranka and Nazzi, Thierry}, title = {Variability and stability in early language acquisition}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {683}, issn = {1866-8364}, doi = {10.25932/publishup-46971}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469718}, pages = {18}, year = {2019}, abstract = {Many human infants grow up learning more than one language simultaneously but only recently has research started to study early language acquisition in this population more systematically. The paper gives an overview on findings on early language acquisition in bilingual infants during the first two years of life and compares these findings to current knowledge on early language acquisition in monolingual infants. Given the state of the research, the overview focuses on research on phonological and early lexical development in the first two years of life. We will show that the developmental trajectory of early language acquisition in these areas is very similar in mono- and bilingual infants suggesting that these early steps into language are guided by mechanisms that are rather robust against the differences in the conditions of language exposure that mono- and bilingual infants typically experience.}, language = {en} } @misc{Fandino2019, author = {Fandi{\~n}o, Jorge}, title = {Founded (auto)epistemic equilibrium logic satisfies epistemic splitting}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1060}, issn = {1866-8372}, doi = {10.25932/publishup-46968}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469685}, pages = {671 -- 687}, year = {2019}, abstract = {In a recent line of research, two familiar concepts from logic programming semantics (unfounded sets and splitting) were extrapolated to the case of epistemic logic programs. The property of epistemic splitting provides a natural and modular way to understand programs without epistemic cycles but, surprisingly, was only fulfilled by Gelfond's original semantics (G91), among the many proposals in the literature. On the other hand, G91 may suffer from a kind of self-supported, unfounded derivations when epistemic cycles come into play. Recently, the absence of these derivations was also formalised as a property of epistemic semantics called foundedness. Moreover, a first semantics proved to satisfy foundedness was also proposed, the so-called Founded Autoepistemic Equilibrium Logic (FAEEL). In this paper, we prove that FAEEL also satisfies the epistemic splitting property something that, together with foundedness, was not fulfilled by any other approach up to date. To prove this result, we provide an alternative characterisation of FAEEL as a combination of G91 with a simpler logic we called Founded Epistemic Equilibrium Logic (FEEL), which is somehow an extrapolation of the stable model semantics to the modal logic S5.}, language = {en} } @misc{ClahsenJessen2019, author = {Clahsen, Harald and Jessen, Anna}, title = {Do bilingual children lag behind?}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {682}, issn = {1866-8364}, doi = {10.25932/publishup-46972}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469727}, pages = {27}, year = {2019}, abstract = {The current study investigates how bilingual children encode and produce morphologically complex words. We employed a silent-production-plus-delayed-vocalization paradigm in which event-related brain potentials (ERPs) were recorded during silent encoding of inflected words which were subsequently cued to be overtly produced. The bilingual children's spoken responses and their ERPs were compared to previous datasets from monolingual children on the same task. We found an enhanced negativity for regular relative to irregular forms during silent production in both bilingual children's languages, replicating the ERP effect previously obtained from monolingual children. Nevertheless, the bilingual children produced more morphological errors (viz. over-regularizations) than monolingual children. We conclude that mechanisms of morphological encoding (as measured by ERPs) are parallel for bilingual and monolingual children, and that the increased over-regularization rates are due to their reduced exposure to each of the two languages (relative to monolingual children).}, language = {en} } @misc{WeberTiefenbacherGronau2019, author = {Weber, Edzard and Tiefenbacher, Anselm and Gronau, Norbert}, title = {Need for standardization and systematization of test data for job-shop scheduling}, series = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {134}, issn = {1867-5808}, doi = {10.25932/publishup-47222}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-472229}, pages = {23}, year = {2019}, abstract = {The development of new and better optimization and approximation methods for Job Shop Scheduling Problems (JSP) uses simulations to compare their performance. The test data required for this has an uncertain influence on the simulation results, because the feasable search space can be changed drastically by small variations of the initial problem model. Methods could benefit from this to varying degrees. This speaks in favor of defining standardized and reusable test data for JSP problem classes, which in turn requires a systematic describability of the test data in order to be able to compile problem adequate data sets. This article looks at the test data used for comparing methods by literature review. It also shows how and why the differences in test data have to be taken into account. From this, corresponding challenges are derived which the management of test data must face in the context of JSP research. Keywords}, language = {en} } @misc{ZollDiehlSiebert2019, author = {Zoll, Felix and Diehl, Katharina and Siebert, Rosemarie}, title = {Integrating sustainability goals in innovation processes}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {1036}, issn = {1866-8372}, doi = {10.25932/publishup-47342}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473420}, pages = {17}, year = {2019}, abstract = {The innovative dual-purpose chicken approach aims at contributing to the transition towards sustainable poultry production by avoiding the culling of male chickens. To successfully integrate sustainability aspects into innovation, goal congruency among actors and clearly communicating the added value within the actor network and to consumers is needed. The challenge of identifying common sustainability goals calls for decision support tools. The objectives of our research were to investigate whether the tool could assist in improving communication and marketing with respect to sustainability and optimizing the value chain organization. Three actor groups participated in the tool application, in which quantitative and qualitative data were collected. The results showed that there were manifold sustainability goals within the innovation network, but only some goals overlapped, and the perception of their implementation also diverged. While easily marketable goals such as 'animal welfare' were perceived as being largely implemented, economic goals were prioritized less often, and the implementation was perceived as being rather low. By visualizing congruencies and differences in the goals, the tool helped identify fields of action, such as improved information flows and prompted thinking processes. We conclude that the tool is useful for managing complex decision processes with several actors involved.}, language = {en} } @misc{Felser2019, author = {Felser, Claudia}, title = {Do processing resource limitations shape heritage language grammars?}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {676}, issn = {1866-8364}, doi = {10.25932/publishup-46970}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469703}, pages = {23 -- 24}, year = {2019}, abstract = {kein abstract vorhanden}, language = {en} } @misc{GarciaRoeserHoehle2019, author = {Garcia, Rowena and Roeser, Jens and H{\"o}hle, Barbara}, title = {Children's online use of word order and morphosyntactic markers in Tagalog thematic role assignment}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {673}, issn = {1866-8364}, doi = {10.25932/publishup-46967}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-469678}, pages = {533 -- 555}, year = {2019}, abstract = {We investigated whether Tagalog-speaking children incrementally interpret the first noun as the agent, even if verbal and nominal markers for assigning thematic roles are given early in Tagalog sentences. We asked five- and seven-year-old children and adult controls to select which of two pictures of reversible actions matched the sentence they heard, while their looks to the pictures were tracked. Accuracy and eye-tracking data showed that agent-initial sentences were easier to comprehend than patient-initial sentences, but the effect of word order was modulated by voice. Moreover, our eye-tracking data provided evidence that, by the first noun phrase, seven-year-old children looked more to the target in the agent-initial compared to the patient-initial conditions, but this word order advantage was no longer observed by the second noun phrase. The findings support language processing and acquisition models which emphasize the role of frequency in developing heuristic strategies (e.g., Chang, Dell, \& Bock, 2006).}, language = {en} }