@article{EsfahaniGholamiOhrnberger2020,
  author    = {Esfahani, Reza Dokht Dolatabadi and Gholami, Ali and Ohrnberger, Matthias},
  title     = {An inexact augmented Lagrangian method for nonlinear dispersion-curve inversion using Dix-type global linear approximation},
  series = {Geophysics : a journal of general and applied geophysics},
  volume    = {85},
  journal   = {Geophysics : a journal of general and applied geophysics},
  number    = {3},
  publisher = {GeoScienceWorld},
  address   = {Tulsa, Okla.},
  issn      = {0016-8033},
  doi       = {10.1190/geo2019-0717.1},
  pages     = {EN77 -- EN85},
  year      = {2020},
  abstract  = {Dispersion-curve inversion of Rayleigh waves to infer subsurface shear-wave velocity is a long-standing problem in seismology. Due to nonlinearity and ill-posedness, sophisticated regularization techniques are required to solve the problem for a stable velocity model. We have formulated the problem as a minimization problem with nonlinear operator constraint and then solve it by using an inexact augmented Lagrangian method, taking advantage of the Haney-Tsai Dix-type relation (a global linear approximation of the nonlinear forward operator). This replaces the original regularized nonlinear problem with iterative minimization of a more tractable regularized linear problem followed by a nonlinear update of the phase velocity (data) in which the update can be performed accurately with any forward modeling engine, for example, the finite-element method. The algorithm allows discretizing the medium with thin layers (for the finite-element method) and thus omitting the layer thicknesses from the unknowns and also allows incorporating arbitrary regularizations to shape the desired velocity model. In this research, we use total variation regularization to retrieve the shear-wave velocity model. We use two synthetic and two real data examples to illustrate the performance of the inversion algorithm with total variation regularization. We find that the method is fast and stable, and it converges to the solution of the original nonlinear problem.},
  language  = {en}
}
@article{RaoufiHoermannLigorioetal.2020,
  author    = {Raoufi, Meysam and H{\"o}rmann, Ulrich and Ligorio, Giovanni and Hildebrandt, Jana and P{\"a}tzel, Michael and Schultz, Thorsten and Perdig{\´o}n-Toro, Lorena and Koch, Norbert and List-Kratochvil, Emil and Hecht, Stefan and Neher, Dieter},
  title     = {Simultaneous effect of ultraviolet radiation and surface modification on the work function and hole injection properties of ZnO thin films},
  series = {Physica Status Solidi. A , Applications and materials science},
  volume    = {217},
  journal   = {Physica Status Solidi. A , Applications and materials science},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.201900876},
  pages     = {1 -- 6},
  year      = {2020},
  abstract  = {The combined effect of ultraviolet (UV) light soaking and self-assembled monolayer deposition on the work function (WF) of thin ZnO layers and on the efficiency of hole injection into the prototypical conjugated polymer poly(3-hexylthiophen-2,5-diyl) (P3HT) is systematically investigated. It is shown that the WF and injection efficiency depend strongly on the history of UV light exposure. Proper treatment of the ZnO layer enables ohmic hole injection into P3HT, demonstrating ZnO as a potential anode material for organic optoelectronic devices. The results also suggest that valid conclusions on the energy-level alignment at the ZnO/organic interfaces may only be drawn if the illumination history is precisely known and controlled. This is inherently problematic when comparing electronic data from ultraviolet photoelectron spectroscopy (UPS) measurements carried out under different or ill-defined illumination conditions.},
  language  = {en}
}
@article{JareckiTanJenny2020,
  author    = {Jarecki, Jana B. and Tan, Jolene H. and Jenny, Mirjam},
  title     = {A framework for building cognitive process models},
  series = {Psychonomic bulletin \& review : a journal of the Psychonomic Society},
  volume    = {27},
  journal   = {Psychonomic bulletin \& review : a journal of the Psychonomic Society},
  number    = {6},
  publisher = {Springer},
  address   = {New York, NY},
  issn      = {1069-9384},
  doi       = {10.3758/s13423-020-01747-2},
  pages     = {1218 -- 1229},
  year      = {2020},
  abstract  = {The termprocess modelis widely used, but rarely agreed upon. This paper proposes a framework for characterizing and building cognitive process models. Process models model not only inputs and outputs but also model the ongoing information transformations at a given level of abstraction. We argue that the following dimensions characterize process models: They have a scope that includes different levels of abstraction. They specify a hypothesized mental information transformation. They make predictions not only for the behavior of interest but also for processes. The models' predictions for the processes can be derived from the input, without reverse inference from the output data. Moreover, the presumed information transformation steps are not contradicting current knowledge of human cognitive capacities. Lastly, process models require a conceptual scope specifying levels of abstraction for the information entering the mind, the proposed mental events, and the behavior of interest. This framework can be used for refining models before testing them or after testing them empirically, and it does not rely on specific modeling paradigms. It can be a guideline for developing cognitive process models. Moreover, the framework can advance currently unresolved debates about which models belong to the category of process models.},
  language  = {en}
}
@article{TeraoGarattiniRomaoetal.2020,
  author    = {Terao, Mineko and Garattini, Enrico and Rom{\~a}o, Maria Jo{\~a}o and Leimk{\"u}hler, Silke},
  title     = {Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes},
  series = {The journal of biological chemistry},
  volume    = {295},
  journal   = {The journal of biological chemistry},
  number    = {16},
  publisher = {American Society for Biochemistry and Molecular Biology},
  address   = {Rockville},
  issn      = {0021-9258},
  doi       = {10.1074/jbc.REV119.007741},
  pages     = {5377 -- 5389},
  year      = {2020},
  abstract  = {Aldehyde oxidases (AOXs) are a small group of enzymes belonging to the larger family of molybdo-flavoenzymes, along with the well-characterized xanthine oxidoreductase. The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles and the oxidation of aldehydes to their corresponding carboxylic acids. Different animal species have different complements of AOX genes. The two extremes are represented in humans and rodents; whereas the human genome contains a single active gene (AOX1), those of rodents, such as mice, are endowed with four genes (Aox1-4), clustering on the same chromosome, each encoding a functionally distinct AOX enzyme. It still remains enigmatic why some species have numerous AOX enzymes, whereas others harbor only one functional enzyme. At present, little is known about the physiological relevance of AOX enzymes in humans and their additional forms in other mammals. These enzymes are expressed in the liver and play an important role in the metabolisms of drugs and other xenobiotics. In this review, we discuss the expression, tissue-specific roles, and substrate specificities of the different mammalian AOX enzymes and highlight insights into their physiological roles.},
  language  = {en}
}
@article{KunstmannEngstroemWehleetal.2020,
  author    = {Kunstmann, Ruth Sonja and Engstr{\"o}m, Olof and Wehle, Marko and Widmalm, G{\"o}ran and Santer, Mark and Barbirz, Stefanie},
  title     = {Increasing the affinity of an O-Antigen polysaccharide binding site in Shigella flexneri bacteriophage Sf6 tailspike protein},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {32},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0947-6539},
  doi       = {10.1002/chem.202000495},
  pages     = {7263 -- 7273},
  year      = {2020},
  abstract  = {Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analysed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D H-1,H-1-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide (PS) with surface plasmon resonance. In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design.},
  language  = {en}
}
@article{KoesterMattHess2020,
  author    = {K{\"o}ster, Antonia and Matt, Christian and Hess, Thomas},
  title     = {Do all roads lead to Rome?},
  series = {Business and Information Systems Engineering},
  volume    = {63},
  journal   = {Business and Information Systems Engineering},
  publisher = {Springer},
  address   = {Wiesbaden},
  issn      = {1867-0202},
  doi       = {10.1007/s12599-020-00660-1},
  pages     = {349 -- 366},
  year      = {2020},
  abstract  = {Content website providers have two main goals: They seek to attract consumers and to keep them on their websites as long as possible. To reach potential consumers, they can utilize several online channels, such as paid search results or advertisements on social media, all of which usually require a substantial marketing budget. However, with rising user numbers of online communication tools, website providers increasingly integrate social sharing buttons on their websites to encourage existing consumers to facilitate referrals to their social networks. While little is known about this social form of guiding consumers to a content website, the study proposes that the way in which consumers reach a website is related to their stickiness to the website and their propensity to refer content to others. By using a unique clickstream data set of a video-on-demand website, the study compares consumers referred by their social network to those consumers arriving at the website via organic search or social media advertisements in terms of stickiness to the website (e.g., visit length, number of page views, video starts) and referral likelihood. The results show that consumers referred through social referrals spend more time on the website, view more pages, and start more videos than consumers who respond to social media advertisements, but less than those coming through organic search. Concerning referral propensity, the results indicate that consumers attracted to a website through social referrals are more likely to refer content to others than those who came through organic search or social media advertisements. The study offers direct insights to managers and recommends an increase in their efforts to promote social referrals on their websites.},
  language  = {en}
}
@article{GriscomBuschCookPattonetal.2020,
  author    = {Griscom, Bronson W. and Busch, Jonah and Cook-Patton, Susan C. and Ellis, Peter W. and Funk, Jason and Leavitt, Sara M. and Lomax, Guy and Turner, Will R. and Chapman, Melissa and Streck, Charlotte},
  title     = {National mitigation potential from natural climate solutions in the tropics},
  series = {Biological sciences},
  volume    = {375},
  journal   = {Biological sciences},
  number    = {1794},
  publisher = {The Royal Society Publishing},
  address   = {London},
  issn      = {0962-8436},
  doi       = {10.1098/rstb.2019.0126},
  pages     = {1 -- 11},
  year      = {2020},
  abstract  = {Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2 degrees C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO(2)e yr(-1) at less than 100 US\$ per Mg CO(2)e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'.},
  language  = {en}
}
@article{ThirumalaikumarGorkaSchulzetal.2020,
  author    = {Thirumalaikumar, Venkatesh P. and Gorka, Michal and Schulz, Karina and Masclaux-Daubresse, Celine and Sampathkumar, Arun and Skirycz, Aleksandra and Vierstra, Richard D. and Balazadeh, Salma},
  title     = {Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1},
  series = {Autophagy},
  volume    = {17},
  journal   = {Autophagy},
  number    = {9},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1554-8635},
  doi       = {10.1080/15548627.2020.1820778},
  pages     = {2184 -- 2199},
  year      = {2020},
  abstract  = {In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to complete their life cycles, plants require a dynamic balance between capacities to recover following cessation of stress and maintenance of stress memory. Recently, we uncovered a new functional role for macroautophagy/autophagy in regulating recovery from heat stress (HS) and resetting cellular memory of HS inArabidopsis thaliana. Here, we demonstrated that NBR1 (next to BRCA1 gene 1) plays a crucial role as a receptor for selective autophagy during recovery from HS. Immunoblot analysis and confocal microscopy revealed that levels of the NBR1 protein, NBR1-labeled puncta, and NBR1 activity are all higher during the HS recovery phase than before. Co-immunoprecipitation analysis of proteins interacting with NBR1 and comparative proteomic analysis of annbr1-null mutant and wild-type plants identified 58 proteins as potential novel targets of NBR1. Cellular, biochemical and functional genetic studies confirmed that NBR1 interacts with HSP90.1 (heat shock protein 90.1) and ROF1 (rotamase FKBP 1), a member of the FKBP family, and mediates their degradation by autophagy, which represses the response to HS by attenuating the expression ofHSPgenes regulated by the HSFA2 transcription factor. Accordingly, loss-of-function mutation ofNBR1resulted in a stronger HS memory phenotype. Together, our results provide new insights into the mechanistic principles by which autophagy regulates plant response to recurrent HS.},
  language  = {en}
}
@article{GleichSpittaButleretal.2020,
  author    = {Gleich, Tobias and Spitta, Gianna and Butler, Oisin and Zacharias, Kristin and Aydin, Semiha and Sebold, Miriam and Garbusow, Maria and Rapp, Michael A. and Schubert, Florian and Buchert, Ralph and Heinz, Andreas and Gallinat, J{\"u}rgen},
  title     = {Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk},
  series = {Addiction Biology},
  volume    = {26},
  journal   = {Addiction Biology},
  number    = {2},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {1369-1600},
  doi       = {10.1111/adb.12915},
  pages     = {1 -- 10},
  year      = {2020},
  abstract  = {Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future.},
  language  = {en}
}
@article{LeinsBanitzGrimmetal.2020,
  author    = {Leins, Johannes A. and Banitz, Thomas and Grimm, Volker and Drechsler, Martin},
  title     = {High-resolution PVA along large environmental gradients to model the combined effects of climate change and land use timing},
  series = {Ecological modelling : international journal on ecological modelling and systems ecology},
  volume    = {440},
  journal   = {Ecological modelling : international journal on ecological modelling and systems ecology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0304-3800},
  doi       = {10.1016/j.ecolmodel.2020.109355},
  pages     = {15},
  year      = {2020},
  abstract  = {Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors.},
  language  = {en}
}