@misc{Kuettner2019,
  author    = {K{\"u}ttner, Uwe-Alexander},
  title     = {At the intersection of stance-management and repair},
  series = {Postprints der Universit{\"a}t Potsdam : Philosophische Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Philosophische Reihe},
  issn      = {1866-8380},
  doi       = {10.25932/publishup-44348},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-443485},
  pages     = {115 -- 156},
  year      = {2019},
  abstract  = {This article offers an in-depth analysis of one particular type of meta-talk. It looks at how speakers use the meta-pragmatic claim to have previously communicated ('said' or 'meant') the same as, or the equivalent of, what their interlocutor just said. Through detailed sequential analyses, it is shown that this claim is frequently used as a practice for disarming disaffiliative responses and thus to manage (and often resolve) incipient disagreement. Besides unpacking the precise mechanisms underlying this practice, the paper also takes stock of the various (and partly variable) lexico-morpho-syntactic, prosodic and bodily-visual elements of conduct that recurrently enter into its composition. Since the practice essentially rests on the speaker's insinuation of having been misunderstood by their co-participant, its relationship to the organization of repair will also be discussed. It is argued that the practice operates precisely at the intersection of stance-management (agreement/disagreement) and repair, and that it exhibits features which reflect this intersectional character. Data are in English.},
  language  = {en}
}
@misc{PieperWeheBornhorstetal.2014,
  author    = {Pieper, Imke and Wehe, Christoph A. and Bornhorst, Julia and Ebert, Franziska and Leffers, Larissa and Holtkamp, Michael and H{\"o}seler, Pia and Weber, Till and Mangerich, Aswin and B{\"u}rkle, Alexander and Karst, Uwe and Schwerdtle, Tanja},
  title     = {Mechanisms of Hg species induced toxicity in cultured human astrocytes},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-74379},
  pages     = {662 -- 671},
  year      = {2014},
  abstract  = {The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organic Hg species. Mercury species investigated include MeHgCl and thiomersal. Additionally HgCl2 was studied, since in the brain mercuric Hg can be formed by dealkylation of the organic species. As a cellular system astrocytes were used. In vivo astrocytes provide the environment necessary for neuronal function. In the present study, cytotoxic effects of the respective mercuricals increased with rising alkylation level and correlated with their cellular bioavailability. Further experiments revealed for all species at subcytotoxic concentrations no induction of DNA strand breaks, whereas all species massively increased H2O2-induced DNA strand breaks. This co- genotoxic effect is likely due to a disturbance of the cellular DNA damage response. Thus, at nanomolar, sub-cytotoxic concentrations, all three mercury species strongly disturbed poly(ADP-ribosyl)ation, a signalling reaction induced by DNA strand breaks. Interestingly, the molecular mechanism behind this inhibition seems to be different for the species. Since chronic PARP-1 inhibition is also discussed to sacrifice neurogenesis and learning abilities, further experiments on neurons and in vivo studies could be helpful to clarify whether the inhibition of poly(ADP-ribosyl) ation contributes to organic Hg induced neurotoxicity.},
  language  = {en}
}