@article{VogelRackwitzSchuermanetal.2015,
  author    = {Vogel, Stefanie and Rackwitz, Jenny and Schuerman, Robin and Prinz, Julia and Milosavljevic, Aleksandar R. and Refregiers, Matthieu and Giuliani, Alexandre and Bald, Ilko},
  title     = {Using DNA origami nanostructures to determine absolute cross sections for UV photon-induced DNA strand breakage},
  series = {The journal of physical chemistry letters},
  volume    = {6},
  journal   = {The journal of physical chemistry letters},
  number    = {22},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1948-7185},
  doi       = {10.1021/acs.jpclett.5b02238},
  pages     = {4589 -- 4593},
  year      = {2015},
  abstract  = {We have characterized ultraviolet (UV) photon-induced DNA strand break processes by determination of absolute cross sections for photoabsorption and for sequence-specific DNA single strand breakage induced by photons in an energy range from 6.50 to 8.94 eV. These represent the lowest-energy photons able to induce DNA strand breaks. Oligonudeotide targets are immobilized on a UV transparent substrate in controlled quantities through attachment to DNA origami templates. Photon-induced dissociation of single DNA strands is visualized and quantified using atomic force microscopy. The obtained quantum yields for strand breakage vary between 0.06 and 0.5, indicating highly efficient DNA strand breakage by UV photons, which is clearly dependent on the photon energy. Above the ionization threshold strand breakage becomes clearly the dominant form of DNA radiation damage, which is then also dependent on the nucleotide sequence.},
  language  = {en}
}