@article{RosencrantzTangSchulteOsseilietal.2019,
  author    = {Rosencrantz, Sophia and Tang, Jo Sing Julia and Schulte-Osseili, Christine and B{\"o}ker, Alexander and Rosencrantz, Ruben R.},
  title     = {Glycopolymers by RAFT Polymerization as Functional Surfaces for Galectin-3},
  series = {Macromolecular chemistry and physics},
  volume    = {220},
  journal   = {Macromolecular chemistry and physics},
  number    = {20},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1022-1352},
  doi       = {10.1002/macp.201900293},
  pages     = {7},
  year      = {2019},
  abstract  = {Glycan-protein interactions are essential biological processes with many disease-related modulations and variations. One of the key proteins involved in tumor progression and metastasis is galectin-3 (Gal-3). A lot of effort is put into the development of Gal-3 inhibitors as new therapeutic agents. The avidity of glycan-protein interactions is strongly enhanced by multivalent ligand presentation. Multivalent presentation of glycans can be accomplished by utilizing glycopolymers, which are polymers with pendent glycan groups. For the production of glycopolymers, glycomonomers are synthesized by a regioselective, microwave-assisted approach starting from lactose. The resulting methacrylamide derivatives are polymerized by RAFT and immobilized on gold surfaces using the trithiocarbonate group of the chain transfer agent. Surface plasmon resonance spectroscopy enables the label free kinetic characterization of Gal-3 binding to these multivalent glycopolymers. The measurements indicate oligomerization of Gal-3 upon exposure to multivalent environments and reveal strong specific interaction with the immobilized polymers.},
  language  = {en}
}
@article{TangSmaczniakTepperetal.2022,
  author    = {Tang, Jo Sing Julia and Smaczniak, Aline Debrassi and Tepper, Lucas and Rosencrantz, Sophia and Aleksanyan, Mina and D{\"a}hne, Lars and Rosencrantz, Ruben R.},
  title     = {Glycopolymer based LbL multilayer thin films with embedded liposomes},
  series = {Macromolecular bioscience},
  volume    = {22},
  journal   = {Macromolecular bioscience},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1616-5187},
  doi       = {10.1002/mabi.202100461},
  pages     = {9},
  year      = {2022},
  abstract  = {Layer-by-layer (LbL) self-assembly emerged as an efficient technique for fabricating coating systems for, e.g., drug delivery systems with great versatility and control. In this work, protecting group free and aqueous-based syntheses of bioinspired glycopolymer electrolytes aredescribed. Thin films of the glycopolymers are fabricated by LbL self-assembly and function as scaffolds for liposomes, which potentially can encapsulate active substances. The adsorbed mass, pH stability, and integrity of glycopolymer coatings as well as the embedded liposomes are investigated via whispering gallery mode (WGM) technology and quartz crystal microbalance with dissipation (QCM-D) monitoring , which enable label-free characterization. Glycopolymer thin films, with and without liposomes, are stable in the physiological pH range. QCM-D measurements verify the integrity of lipid vesicles. Thus, the fabrication of glycopolymer-based surface coatings with embedded and intact liposomes is presented.},
  language  = {en}
}