@article{KleinpeterSzatmariLazaretal.2009,
  author    = {Kleinpeter, Erich and Szatm{\´a}ri, Istv{\´a}n and L{\´a}z{\´a}r, L{\´a}szl{\´o} and Koch, Andreas and Heydenreich, Matthias and Fulop, Ferenc},
  title     = {Visualization and quantification of anisotropic effects on the 1H NMR spectra of 1,3-oxazino[4,3- alpha]isoquinolines - indirect estimates of steric compression},
  issn      = {0040-4020},
  doi       = {10.1016/j.tet.2009.07.038},
  year      = {2009},
  abstract  = {The anisotropic effects of the phenyl, alpha- and beta-naphthyl moieties in four series of 1,3-oxazino[4,3- a]isoquinolines on the H-1 chemical shifts of the isoquinoline protons were calculated by employing the Nucleus Independent Chemical Shift (NICS) concept and Visualized as anisotropic cones by a through-space NMR shielding grid. The signs and extents of these spatial effects on the H-1 chemical shifts of the isoquinoline protons were compared with the experimental H-1 NMR spectra. The differences between the experimental delta (H-1)/ppm values and the calculated anisotropic effects of the aromatic moieties are discussed in terms of the steric compression that occurs in the Compounds studied.},
  language  = {en}
}