@article{MarcoDeyouGruhonjicetal.2017,
  author    = {Marco, Makungu and Deyou, Tsegaye and Gruhonjic, Amra and Holleran, John and Duffy, Sandra and Heydenreich, Matthias and Firtzpatrick, Paul A. and Landberg, Goran and Koch, Andreas and Derese, Solomon and Pelletier, Jerry and Avery, Vicky M. and Erdelyi, Mate and Yenesew, Abiy},
  title     = {Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura},
  series = {Phytochemistry letters},
  volume    = {21},
  journal   = {Phytochemistry letters},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1874-3900},
  doi       = {10.1016/j.phytol.2017.07.012},
  pages     = {216 -- 220},
  year      = {2017},
  language  = {en}
}
@article{DeyouMarcoHeydenreichetal.2017,
  author    = {Deyou, Tsegaye and Marco, Makungu and Heydenreich, Matthias and Pan, Fangfang and Gruhonjic, Amra and Fitzpatrick, Paul A. and Koch, Andreas and Derese, Solomon and Pelletier, Jerry and Rissanen, Kari and Yenesew, Abiy and Erdelyi, Mate},
  title     = {Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp teitensis},
  series = {Journal of natural products},
  volume    = {80},
  journal   = {Journal of natural products},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {0163-3864},
  doi       = {10.1021/acs.jnatprod.7b00255},
  pages     = {2060 -- 2066},
  year      = {2017},
  abstract  = {A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 mu M, respectively.},
  language  = {en}
}
@article{MuthauraKerikoMutaietal.2017,
  author    = {Muthaura, Charles N. and Keriko, Joseph M. and Mutai, Charles and Yenesew, Abiy and Heydenreich, Matthias and Atilaw, Yoseph and Gathirwa, Jeremiah W. and Irungu, Beatrice N. and Derese, Solomon},
  title     = {Antiplasmodial, cytotoxicity and phytochemical constituents of four maytenus species used in traditional medicine in Kenya},
  series = {The natural products journal},
  volume    = {7},
  journal   = {The natural products journal},
  number    = {2},
  publisher = {Bentham Science Publ.},
  address   = {Sharjah},
  issn      = {2210-3155},
  doi       = {10.2174/2210315507666161206144050},
  pages     = {144 -- 152},
  year      = {2017},
  abstract  = {Background: In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity. Objective: To isolate antiplasmodial compounds from these plant species which could be used as marker compounds in the standardization of their extracts as a phytomedicine for malaria. Methods: Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy. Results: Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed promising antiplasmodial activity with IC50, 3.63 and 3.95 ng/ml against chloroquine sensitive (D6) and resistant (W2) P. falciparum, respectively and moderate cytotoxicity (CC50, 37.5 ng/ml) against Vero E6 cells. The other compounds showed weak antiplasmodial (IC50 > 1.93 mu g/ml) and cytotoxic (CC50 > 39.52 mu g/ml) activities against P. falciparum and Vero E6 cells, respectively. Conclusion: (20 alpha)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methyl-ester (pristimerin) (1) was the most active marker and lead compound that warrants further investigation as a template for the development of new antimalarial drugs. Pristimerin is reported for the first time in M. putterlickioides. 3-Hydroxyolean-12-en-28-oic acid (oleanolic acid) (5), stigmast-5-en-3-ol (beta-sitosterol) (6), 3-oxo-28-friedelanoic acid (7), olean-12-en-3-ol (beta-amyrin) (8), lup-20(29)-en-3-ol (lupeol) (9) and lup-20(29)-en-3-one (lupenone) (10) are reported for the first time in M. undata.},
  language  = {en}
}