@article{XiangGaoCaietal.2017,
  author    = {Xiang, Hai and Gao, Jianqiang and Cai, Dawei and Luo, Yunbing and Yu, Baoquan and Liu, Langqing and Liu, Ranran and Zhou, Hui and Chen, Xiaoyong and Dun, Weitao and Wang, Xi and Hofreiter, Michael and Zhao, Xingbo},
  title     = {Origin and dispersal of early domestic pigs in northern China},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-06056-8},
  pages     = {9},
  year      = {2017},
  abstract  = {It is widely accepted that modern pigs were domesticated independently at least twice, and Chinese native pigs are deemed as direct descendants of the first domesticated pigs in the corresponding domestication centers. By analyzing mitochondrial DNA sequences of an extensive sample set spanning 10,000 years, we find that the earliest pigs from the middle Yellow River region already carried the maternal lineages that are dominant in both younger archaeological populations and modern Chinese pigs. Our data set also supports early Neolithic pig utilization and a long-term in situ origin for northeastern Chinese pigs during 8,000-3,500 BP, suggesting a possibly independent domestication in northeast China. Additionally, we observe a genetic replacement in ancient northeast Chinese pigs since 3,500 BP. The results not only provide increasing evidence for pig origin in the middle Yellow River region but also depict an outline for the process of early pig domestication in northeast China.},
  language  = {en}
}
@article{BremerKentHaussetal.2017,
  author    = {Bremer, Anne and Kent, Ben and Hauss, Thomas and Thalhammer, Anja and Yepuri, Nageshwar R. and Darwish, Tamim A. and Garvey, Christopher J. and Bryant, Gary and Hincha, Dirk K.},
  title     = {Intrinsically Disordered Stress Protein COR15A Resides at the Membrane Surface during Dehydration},
  series = {Biophysical journal},
  volume    = {113},
  journal   = {Biophysical journal},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {0006-3495},
  doi       = {10.1016/j.bpj.2017.06.027},
  pages     = {572 -- 579},
  year      = {2017},
  abstract  = {Plants from temperate climate zones are able to increase their freezing tolerance during exposure to low, above zero temperatures in a process termed cold acclimation. During this process, several cold-regulated (COR) proteins are accumulated in the cells. One of them is COR15A, a small, intrinsically disordered protein that contributes to leaf freezing tolerance by stabilizing cellular membranes. The isolated protein folds into amphipathic a-helices in response to increased crowding conditions, such as high concentrations of glycerol. Although there is evidence for direct COR15A-membrane interactions, the orientation and depth of protein insertion were unknown. In addition, although folding due to high osmolyte concentrations had been established, the folding response of the protein under conditions of gradual dehydration had not been investigated. Here we show, using Fourier transform infrared spectroscopy, that COR15A starts to fold into a-helices already under mild dehydration conditions (97\% relative humidity (RH), corresponding to freezing at -3 degrees C) and that folding gradually increases with decreasing RH. Neutron diffraction experiments at 97 and 75\% RH established that the presence of COR15A had no significant influence on the structure of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes. However, using deuterated POPC we. could clearly establish that COR15A interacts with the membranes and penetrates below the headgroup region into the upper part of the fatty acyl chain region. This localization is in agreement with our hypothesis that COR15A-membrane interaction is at least, in part, driven by a hydrophobic interaction between the lipids and the hydrophobic face of the amphipathic protein alpha-helix.},
  language  = {en}
}
@article{GhaisariWinklhoferStrauchetal.2017,
  author    = {Ghaisari, Sara and Winklhofer, Michael and Strauch, Peter and Klumpp, Stefan and Faivre, Damien},
  title     = {Magnetosome Organization in Magnetotactic Bacteria Unraveled by Ferromagnetic Resonance Spectroscopy},
  series = {Biophysical journal},
  volume    = {113},
  journal   = {Biophysical journal},
  publisher = {Cell Press},
  address   = {Cambridge},
  issn      = {0006-3495},
  doi       = {10.1016/j.bpj.2017.06.031},
  pages     = {637 -- 644},
  year      = {2017},
  abstract  = {Magnetotactic bacteria form assemblies of magnetic nanoparticles called magnetosomes. These magnetosomes are typically arranged in chains, but other forms of assemblies such as clusters can be observed in some species and genetic mutants. As such, the bacteria have developed as a model for the understanding of how organization of particles can influence the magnetic properties. Here, we use ferromagnetic resonance spectroscopy to measure the magnetic anisotropies in different strains of Magnetosprillum gtyphiswaldense MSR-1, a bacterial species that is amendable to genetic mutations. We combine our experimental results with a model describing the spectra. The model includes chain imperfections and misalignments following a Fisher distribution function, in addition to the intrinsic magnetic properties of the magnetosomes. Therefore, by applying the model to analyze the ferromagnetic resonance data, the distribution of orientations in the bulk sample can be retrieved in addition to the average magnetosome arrangement. In this way, we quantitatively characterize the magnetosome arrangement in both wild-type cells and Delta mamJ mutants, which exhibit differing magnetosome organization.},
  language  = {en}
}
@article{KornhuberPetoukhovKarolyetal.2017,
  author    = {Kornhuber, Kai and Petoukhov, Vladimir and Karoly, D. and Petri, Stefan and Rahmstorf, Stefan and Coumou, Dim},
  title     = {Summertime Planetary Wave Resonance in the Northern and Southern Hemispheres},
  series = {Journal of climate},
  volume    = {30},
  journal   = {Journal of climate},
  publisher = {American Meteorological Soc.},
  address   = {Boston},
  issn      = {0894-8755},
  doi       = {10.1175/JCLI-D-16-0703.1},
  pages     = {6133 -- 6150},
  year      = {2017},
  language  = {en}
}
@article{KuecuekgoezeTeraoGarattinietal.2017,
  author    = {Kuecuekgoeze, Goekhan and Terao, Mineko and Garattini, Enrico and Leimk{\"u}hler, Silke},
  title     = {Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse},
  series = {Drug metabolism and disposition : the biological fate of chemicals},
  volume    = {45},
  journal   = {Drug metabolism and disposition : the biological fate of chemicals},
  publisher = {American Society for Pharmacology and Experimental Therapeutics},
  address   = {Bethesda},
  issn      = {0090-9556},
  doi       = {10.1124/dmd.117.075937},
  pages     = {947 -- 955},
  year      = {2017},
  abstract  = {Aldehyde oxidases (AOXs) are molybdoflavoenzymes with an important role in the metabolism and detoxification of heterocyclic compounds and aliphatic as well as aromatic aldehydes. The enzymes use oxygen as the terminal electron acceptor and produce reduced oxygen species during turnover. Four different enzymes, mAOX1, mAOX3, mAOX4, and mAOX2, which are the products of distinct genes, are present in the mouse. A direct and simultaneous comparison of the enzymatic properties and characteristics of the four enzymes has never been performed. In this report, the four catalytically active mAOX enzymes were purified after heterologous expression in Escherichia coli. The kinetic parameters of the four mouse AOX enzymes were determined and compared with the use of six predicted substrates of physiologic and toxicological interest, i.e., retinaldehyde, N1-methylnicotinamide, pyridoxal, vanillin, 4-(dimethylamino) cinnamaldehyde (p-DMAC), and salicylaldehyde. While retinaldehyde, vanillin, p-DMAC, and salycilaldehyde are efficient substrates for the four mouse AOX enzymes, N1-methylnicotinamide is not a substrate of mAOX1 or mAOX4, and pyridoxal is notmetabolized by any of the purified enzymes. Overall, mAOX1, mAOX2, mAOX3, and mAOX4 are characterized by significantly different KM and kcat values for the active substrates. The four mouse AOXs are also characterized by quantitative differences in their ability to produce superoxide radicals. With respect to this last point, mAOX2 is the enzyme generating the largest rate of superoxide radicals of around 40\% in relation to moles of substrate converted, and mAOX1, the homolog to the human enzyme, produces a rate of approximately 30\% of superoxide radicals with the same substrate.},
  language  = {en}
}
@misc{BroekerBarbirz2017,
  author    = {Broeker, Nina K. and Barbirz, Stefanie},
  title     = {Not a barrier but a key: How bacteriophages exploit host's O\&\#8208;antigen as an essential receptor to initiate infection},
  series = {Molecular microbiology},
  volume    = {105},
  journal   = {Molecular microbiology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {0950-382X},
  doi       = {10.1111/mmi.13729},
  pages     = {353 -- 357},
  year      = {2017},
  abstract  = {Tailed bacteriophages specific for Gram\&\#8208;negative bacteria encounter lipopolysaccharide (LPS) during the first infection steps. Yet, it is not well understood how biochemistry of these initial interactions relates to subsequent events that orchestrate phage adsorption and tail rearrangements to initiate cell entry. For many phages, long O\&\#8208;antigen chains found on the LPS of smooth bacterial strains serve as essential receptor recognized by their tailspike proteins (TSP). Many TSP are depolymerases and O\&\#8208;antigen cleavage was described as necessary step for subsequent orientation towards a secondary receptor. However, O\&\#8208;antigen specific host attachment must not always come along with O\&\#8208;antigen degradation. In this issue of Molecular Microbiology Prokhorov et al. report that coliphage G7C carries a TSP that deacetylates O\&\#8208;antigen but does not degrade it, whereas rough strains or strains lacking O\&\#8208;antigen acetylation remain unaffected. Bacteriophage G7C specifically functionalizes its tail by attaching the deacetylase TSP directly to a second TSP that is nonfunctional on the host's O\&\#8208;antigen. This challenges the view that bacteriophages use their TSP only to clear their way to a secondary receptor. Rather, O\&\#8208;antigen specific phages may employ enzymatically active TSP as a tool for irreversible LPS membrane binding to initiate subsequent infection steps.},
  language  = {en}
}
@article{HuangGuoYangetal.2017,
  author    = {Huang, Hongshi and Guo, Jianqiao and Yang, Jie and Jiang, Yanfang and Yu, Yuanyuan and Mueller, Steffen and Ren, Gexue and Ao, Yingfang},
  title     = {Isokinetic angle-specific moments and ratios characterizing hamstring and quadriceps strength in anterior cruciate ligament deficient knees},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-06601-5},
  pages     = {11},
  year      = {2017},
  abstract  = {This study is intended to find more effective and robust clinical diagnostic indices to characterize muscle strength and coordination alternation following anterior cruciate ligament (ACL) rupture. To evaluate angle-specific moments and hamstring (H)/quadriceps (Q) ratios, 46 male subjects with unilateral chronic ACL-rupture performed isokinetic concentric (c), eccentric (e) quadriceps and hamstring muscle tests respectively at 60 degrees/s. Normalized moments and H/Q ratios were calculated for peak moment (PM) and 30 degrees, 40 degrees, 50 degrees, 60 degrees, 70 degrees, 80 degrees knee flexion angles. Furthermore, we introduced single-to-arithmetic-mean (SAM) and single-to-root-mean-square (SRMS) muscle co-contraction ratios, calculating them for specific angles and different contraction repetitions. Normalized PM and 40 degrees specific concentric quadriceps, concentric hamstring strength in the ACL-deficient knee were reduced significantly (P <= 0.05). Concentric angle-specific moments together with Qe/Qc ratios at 40 degrees (d = 0.766 vs. d = 0.654) identify more obvious differences than peak values in ACL ruptured limbs. Furthermore, we found SRMS-QeQc deficits at 40 degrees showed stronger effect than Qe/Qc ratios (d = 0.918 vs. d = 0.766), albeit other ratio differences remained basically the same effect size as the original H/Q ratios. All the newly defined SAM and SRMS indices could decrease variance. Overall, 40 degrees knee moments and SAM/ SRMS ratios might be new potential diagnosis indices for ACL rupture detection.},
  language  = {en}
}
@article{Stober2017,
  author    = {Stober, Sebastian},
  title     = {Toward Studying Music Cognition with Information Retrieval Techniques: Lessons Learned from the OpenMIIR Initiative},
  series = {Frontiers in psychology},
  volume    = {8},
  journal   = {Frontiers in psychology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2017.01255},
  pages     = {17},
  year      = {2017},
  abstract  = {As an emerging sub-field of music information retrieval (MIR), music imagery information retrieval (MIIR) aims to retrieve information from brain activity recorded during music cognition-such as listening to or imagining music pieces. This is a highly interdisciplinary endeavor that requires expertise in MIR as well as cognitive neuroscience and psychology. The OpenMIIR initiative strives to foster collaborations between these fields to advance the state of the art in MIIR. As a first step, electroencephalography (EEG) recordings ofmusic perception and imagination have beenmade publicly available, enabling MIR researchers to easily test and adapt their existing approaches for music analysis like fingerprinting, beat tracking or tempo estimation on this new kind of data. This paper reports on first results of MIIR experiments using these OpenMIIR datasets and points out how these findings could drive new research in cognitive neuroscience.},
  language  = {en}
}
@article{MeyerSchroeterHahnetal.2017,
  author    = {Meyer, Susann and Schroeter, M. -A. and Hahn, Marc B. and Solomun, T. and Sturm, Heinz and Kunte, H. J.},
  title     = {Ectoine can enhance structural changes in DNA in vitro},
  series = {Scientific reports},
  volume    = {7},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-07441-z},
  pages     = {10},
  year      = {2017},
  abstract  = {Strand breaks and conformational changes of DNA have consequences for the physiological role of DNA. The natural protecting molecule ectoine is beneficial to entire bacterial cells and biomolecules such as proteins by mitigating detrimental effects of environmental stresses. It was postulated that ectoine-like molecules bind to negatively charged spheres that mimic DNA surfaces. We investigated the effect of ectoine on DNA and whether ectoine is able to protect DNA from damages caused by ultraviolet radiation (UV-A). In order to determine different isoforms of DNA, agarose gel electrophoresis and atomic force microscopy experiments were carried out with plasmid pUC19 DNA. Our quantitative results revealed that a prolonged incubation of DNA with ectoine leads to an increase in transitions from supercoiled (undamaged) to open circular (single-strand break) conformation at pH 6.6. The effect is pH dependent and no significant changes were observed at physiological pH of 7.5. After UV-A irradiation in ectoine solution, changes in DNA conformation were even more pronounced and this effect was pH dependent. We hypothesize that ectoine is attracted to the negatively charge surface of DNA at lower pH and therefore fails to act as a stabilizing agent for DNA in our in vitro experiments.},
  language  = {en}
}
@article{SchmidtWalzMartinLopezetal.2017,
  author    = {Schmidt, Katja and Walz, Ariane and Martin-Lopez, Berta and Sachse, Rene},
  title     = {Testing socio-cultural valuation methods of ecosystem services to explain land use preferences},
  series = {Ecosystem Services : Science, Policy and Practice},
  volume    = {26},
  journal   = {Ecosystem Services : Science, Policy and Practice},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2212-0416},
  doi       = {10.1016/j.ecoser.2017.07.001},
  pages     = {270 -- 288},
  year      = {2017},
  abstract  = {Socio-cultural valuation still emerges as a methodological field in ecosystem service (ES) research and until now lacks consistent formalisation and balanced application in ES assessments. In this study, we examine the explanatory value of ES values for land use preferences. We use 563 responses to a survey about the Pentland Hills regional park in Scotland. Specifically, we aim to (1) identify clusters of land use preferences by using a novel visualisation tool, (2) test if socio-cultural values of ESs or (3) user characteristics are linked with land use preferences, and (4) determine whether both socio-cultural values of ESs and user characteristics can predict land use preferences. Our results suggest that there are five groups of people with different land use preferences, ranging from forest and nature enthusiasts to traditionalists, multi-functionalists and recreation seekers. Rating and weighting of ESs and user characteristics were associated with different clusters. Neither socio-cultural values nor user characteristics were suitable predictors for land use preferences. While several studies have explored land use preferences by identifying socio-cultural values in the past, our findings imply that in this case study ES values inform about general perceptions but do not replace the assessment of land use preferences. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.},
  language  = {en}
}