@article{GoetheEsserGendtetal.2012,
  author    = {Goethe, Katrin and Esser, G{\"u}nter and Gendt, Anja and Kliegl, Reinhold},
  title     = {Working memory in children tracing age differences and special educational needs to parameters of a formal model},
  series = {Developmental psychology},
  volume    = {48},
  journal   = {Developmental psychology},
  number    = {2},
  publisher = {American Psychological Association},
  address   = {Washington},
  issn      = {0012-1649},
  doi       = {10.1037/a0025660},
  pages     = {459 -- 476},
  year      = {2012},
  abstract  = {Parameters of a formal working-memory model were estimated for verbal and spatial memory updating of children. The model proposes interference though feature overwriting and through confusion of whole elements as the primary cause of working-memory capacity limits. We tested 2 age groups each containing 1 group of normal intelligence and I deficit group. For young children the deficit was developmental dyslexia; for older children it was a general learning difficulty. The interference model predicts less interference through overwriting but more through confusion of whole elements for the dyslexic children than for their age-matched controls. Older children exhibited less interference through confusion of whole elements and a higher processing rate than young children, but general learning difficulty was associated with slower processing than in the age-matched control group. Furthermore, the difference between verbal and spatial updating mapped onto several meaningful dissociations of model parameters.},
  language  = {en}
}
@article{GoetheEsserGendtetal.2012,
  author    = {G{\"o}the, Katrin and Esser, G{\"u}nter and Gendt, Anja and Kliegl, Reinhold},
  title     = {Working memory in children : tracing age differences and special educational needs to parameters of a formal model},
  year      = {2012},
  abstract  = {Parameters of a formal working-memory model were estimated for verbal and spatial memory updating of children. The model proposes interference though feature overwriting and through confusion of whole elements as the primary cause of working-memory capacity limits. We tested 2 age groups each containing 1 group of normal intelligence and 1 deficit group. For young children the deficit was developmental dyslexia; for older children it was a general learning difficulty. The interference model predicts less interference through overwriting but more through confusion of whole elements for the dyslexic children than for their age-matched controls. Older children exhibited less interference through confusion of whole elements and a higher processing rate than young children, but general learning difficulty was associated with slower processing than in the age-matched control group. Furthermore, the difference between verbal and spatial updating mapped onto several meaningful dissociations of model parameters.},
  language  = {en}
}
@article{LauchtEsserSchmidt2002,
  author    = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.},
  title     = {Vulnerability and resilience in the development of children at risk : the role of early mother-child- interaction},
  issn      = {0101-6083},
  year      = {2002},
  language  = {en}
}
@article{HolzBoeckerSchlierBuchmannetal.2017,
  author    = {Holz, Nathalie E. and Boecker-Schlier, Regina and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Baumeister, Sarah and Plichta, Michael M. and Cattrell, Anna and Schumann, Gunter and Esser, G{\"u}nter and Schmidt, Martin and Buitelaar, Jan and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred},
  title     = {Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder},
  series = {Frontiers in human neuroscience},
  volume    = {12},
  journal   = {Frontiers in human neuroscience},
  number    = {2},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {1749-5016},
  doi       = {10.1093/scan/nsw120},
  pages     = {261 -- 272},
  year      = {2017},
  abstract  = {Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2-19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.},
  language  = {en}
}
@article{EsserLauchtSchmidt1996,
  author    = {Esser, G{\"u}nter and Laucht, Manfred and Schmidt, Martin H.},
  title     = {The Significance of Biological and Psychosocial Risks for Behaviour Problems of Children at Preschool age},
  year      = {1996},
  language  = {en}
}
@article{HolzBoeckerSchlierHohmetal.2015,
  author    = {Holz, Nathalie E. and Boecker-Schlier, Regina and Hohm, Erika and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Baumeister, Sarah and Hohmann, Sarah and Wolf, Isabella and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred},
  title     = {The Long-Term Impact of Early Life Poverty on Orbitofrontal Cortex Volume in Adulthood: Results from a Prospective Study Over 25 Years},
  series = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  volume    = {40},
  journal   = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  number    = {4},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0893-133X},
  doi       = {10.1038/npp.2014.277},
  pages     = {996 -- 1004},
  year      = {2015},
  abstract  = {Converging evidence has highlighted the association between poverty and conduct disorder (CD) without specifying neurobiological pathways. Neuroimaging research has emphasized structural and functional alterations in the orbitofrontal cortex (OFC) as one key mechanism underlying this disorder. The present study aimed to clarify the long-term influence of early poverty on OFC volume and its association with CD symptoms in healthy participants of an epidemiological cohort study followed since birth. At age 25 years, voxel-based morphometry was applied to study brain volume differences. Poverty (0 = non-exposed (N = 134), I = exposed (N = 33)) and smoking during pregnancy were determined using a standardized parent interview, and information on maternal responsiveness was derived from videotaped mother infant interactions at the age of 3 months. CD symptoms were assessed by diagnostic interview from 8 to 19 years of age. Information on life stress was acquired at each assessment and childhood maltreatment was measured using retrospective self-report at the age of 23 years. Analyses were adjusted for sex, parental psychopathology and delinquency, obstetric adversity, parental education, and current poverty. Individuals exposed to early life poverty exhibited a lower OFC volume. Moreover, we replicated previous findings of increased CD symptoms as a consequence of childhood poverty. This effect proved statistically mediated by OFC volume and exposure to life stress and smoking during pregnancy, but not by childhood maltreatment and maternal responsiveness. These findings underline the importance of studying the impact of early life adversity on brain alterations and highlight the need for programs to decrease income-related disparities.},
  language  = {en}
}
@article{SchmidBlomeyerBeckeretal.2009,
  author    = {Schmid, Brigitte and Blomeyer, Dorothea and Becker, Katja and Treutlein, Jens and Zimmermann, Ulrich S. and Buchmann, Arlette F. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Rietschel, Marcella and Laucht, Manfred},
  title     = {The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds},
  issn      = {1355-6215},
  doi       = {10.1111/j.1369-1600.2009.00171.x},
  year      = {2009},
  abstract  = {Recent evidence suggests that heterogeneity in the age at onset could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with alcohol and nicotine consumption. The aim of this study was to examine interactions between two DAT1 polymorphisms and different initiation ages with regard to alcohol and tobacco consumption levels and dependence. Two hundred and ninety-one young adults (135 males, 156 females) participating in the Mannheim Study of Children at Risk were genotyped for the 40-bp variable number of tandem repeats (VNTR) and rs27072 polymorphisms of DAT1. Age at initiation was assessed at age 15 and 19 years. Information about current alcohol and tobacco consumption was obtained at age 19 years using self-report measures and structured interviews. Results suggest that age at onset of intensive consumption moderated the association of the DAT1 gene with early adult substance use and dependence, revealing a DAT1 effect only among individuals homozygous for the 10r allele of the 40-bp VNTR who had started daily smoking or being intoxicated early in life. Equally, carriers of the T allele of the rs27072 polymorphism reporting an early age at first intoxication showed higher current alcohol consumption at age 19 years. In contrast, no interaction between rs27072 and the age at first cigarette with regard to later smoking was observed. These findings provide evidence that the DAT1 gene interacts with an early heavy or regular drug exposure of the maturing adolescent brain to predict substance (ab)use in young adulthood. Further studies are required to confirm these findings.},
  language  = {en}
}
@article{LauchtSchmidtEsser2004,
  author    = {Laucht, Manfred and Schmidt, M. H. and Esser, G{\"u}nter},
  title     = {The development of at-risk children in early life},
  year      = {2004},
  language  = {en}
}
@article{IhleEsserSchmidt1999,
  author    = {Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H.},
  title     = {The contribution of developmental psychopathology to the understanding of the aetiology and course of mentl disorders : a prospective study from childhood to early adulthood},
  year      = {1999},
  language  = {en}
}
@article{HoltmannBuchmannEsseretal.2011,
  author    = {Holtmann, Martin and Buchmann, Arlette F. and Esser, G{\"u}nter and Schmidt, Martin H. and Banaschewski, Tobias and Laucht, Manfred},
  title     = {The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment a longitudinal analysis},
  series = {The journal of child psychology and psychiatry},
  volume    = {52},
  journal   = {The journal of child psychology and psychiatry},
  number    = {2},
  publisher = {Wiley-Blackwell},
  address   = {Malden},
  issn      = {0021-9630},
  doi       = {10.1111/j.1469-7610.2010.02309.x},
  pages     = {139 -- 147},
  year      = {2011},
  abstract  = {Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.},
  language  = {en}
}