@article{Micheel2003,
  author    = {Micheel, Burkhard},
  title     = {Monoklonale Antik{\"o}rper},
  year      = {2003},
  language  = {de}
}
@article{WarsinkeLettauWerneretal.2003,
  author    = {Warsinke, Axel and Lettau, Kristian and Werner, Deljana and Micheel, Burkhard and Kwak, Young-Keun},
  title     = {Biomimetic Binders and Catalysts for Sensorics = Biomimetische Binder und Katalysatoren f{\"u}r die Sensorik},
  year      = {2003},
  abstract  = {Biosensors which make use of the high specificity of enzymes, antibodies, and nucleic acids have been described for detection of numerous metabolites, hormones, and nucleic acid sequences. In addition to biological components nowadays biomimetic recognition molecules are also used. Especially antibodies, aptamers, and molecular imprints are promising biomimetics. They could broaden the range of detectable analytes and could increase the functional stability of the sensor. In this publication we describe the generation of biomimetic antibodies and biomimetic molecular imprints for binding creatinine and for hydrolyzing phenylcarbamates to be used in electrochemical sensors.},
  language  = {de}
}
@article{SheriffVogtBaumgartetal.2003,
  author    = {Sheriff, Ahmed and Vogt, B. and Baumgart, Martin and Montag, C. and Hollenbach, B. and Schenk, J{\"o}rg A. and Ulrich, J. and Ellias, F. and Micheel, Burkhard},
  title     = {Intracellular capture of B7 in antigen-presenting cells reduces costimulatory activity},
  year      = {2003},
  abstract  = {CTLA-4 gene constructs were designed to express CTLA-4 exclusively in the endoplasmic reticulum (ER). Four different CTLA-4 gene constructs were transfected into HEK 293 (human embryonic kidney) and A20 (Balb/c mouse B lymphoma) cells. All constructs contained an ER retention signal and coded for CTLA-4 expression in the ER. One of the constructs, which contained the membrane part of CTLA-4, coded for an expression both on the cell surface and in the ER. Three of the expressed CTLA-4 types (including the ER-membrane-expressed form) caused a reduced surface expression of B7 in the A20 cells. Only constructs which allow dimerization of CTLA-4 showed this effect. It is assumed that intracellular CTLA-4 bound B7 and inhibited therefore the transport of B7 to the surface. The binding obviously caused also an enhanced degradation of the complexes because both proteins showed a low concentration in the transfected cell lines. CTLA-4-transfected and B7-reduced A20 cells showed a diminished costimulating activity upon T cells. This was demonstrated by a reduced proliferation of T cells from ovalbumin-immunized Balb/c mice, incubated with ovalbumin peptide-primed CTLA-4-transfected A20 cells.},
  language  = {en}
}