@article{WessigMerkelMueller2015, author = {Wessig, Pablo and Merkel, Roswitha and Mueller, Peter}, title = {Articulated rods - a novel class of molecular rods based on oligospiroketals (OSK)}, series = {Beilstein journal of organic chemistry}, volume = {11}, journal = {Beilstein journal of organic chemistry}, publisher = {Beilstein-Institut zur F{\"o}rderung der Chemischen Wissenschaften}, address = {Frankfurt, Main}, issn = {1860-5397}, doi = {10.3762/bjoc.11.11}, pages = {74 -- 84}, year = {2015}, abstract = {We developed a new type of molecular rods consisting of two (or more) rigid units linked by a flexible joint. Consequently we called these constructs articulated rods (ARs). The syntheses of ARs were carried out by a flexible and modular approach providing access to a number of compounds with various functionalizations in terminal positions. First applications were presented with pyrene, cinnamoyl and anthracenyl labelled ARs.}, language = {en} } @article{WessigBudachThuenemann2015, author = {Wessig, Pablo and Budach, Dennis B. and Th{\"u}nemann, Andreas F.}, title = {Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties}, series = {Chemistry - a European journal}, volume = {21}, journal = {Chemistry - a European journal}, number = {29}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0947-6539}, doi = {10.1002/chem.201501386}, pages = {10466 -- 10471}, year = {2015}, abstract = {The development of novel dendrimers containing oligospiroketal (OSK) rods as building blocks is described. The linkage between the core unit (CU), branching units (BU), and OSK rods relies on the CuAAC reaction between terminal alkynes and azides. Two different strategies of dendrimer synthesis were investigated and it was found that the convergent approach is clearly superior to the divergent one. SAXS measurements and MD simulations indicate that the obtained dendrimer features a globular structure with very low density. Obviously, the OSK rods stabilize a rather loose mass-fractal structure.}, language = {en} } @article{GrimmMeyerCzaplaetal.2013, author = {Grimm, Christiane and Meyer, Thomas and Czapla, Sylvia and Nikolaus, J{\"o}rg and Scheidt, Holger A. and Vogel, Alexander and Herrmann, Andreas and Wessig, Pablo and Huster, Daniel and M{\"u}ller, Peter}, title = {Structure and dynamics of molecular rods in membranes application of a Spin-Labeled rod}, series = {Chemistry - a European journal}, volume = {19}, journal = {Chemistry - a European journal}, number = {8}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0947-6539}, doi = {10.1002/chem.201202500}, pages = {2703 -- 2710}, year = {2013}, abstract = {Molecular rods consisting of a hydrophobic backbone and terminally varying functional groups have been synthesized for applications for the functionalization of membranes. In the present study, we employ a spin-labeled analogue of a recently described new class of molecular rods to characterize their dynamic interactions with membranes. By using the different approaches of ESR and NMR spectroscopy, we show that the spin moiety of the membrane-embedded spin-labeled rod is localized in the upper chain/glycerol region of membranes of different compositions. The rod is embedded within the membrane in a tilted orientation to adjust for the varying hydrophobic thicknesses of these bilayers. This orientation does not perturb the membrane structure. The water solubility of the rod is increased significantly in the presence of certain cyclodextrins. These cyclodextrins also allow the rods to be extracted from the membrane and incorporated into preformed membranes. The latter will improve the future applications of these rods in cellular systems as stable membrane-associated anchors for the functionalization of membrane surfaces.}, language = {en} } @article{WessigGerngrossPapeetal.2014, author = {Wessig, Pablo and Gerngroß, Maik and Pape, Simon and Bruhns, Philipp and Weber, Jens}, title = {Novel porous materials based on oligospiroketals (OSK)}, series = {RSC Advances : an international journal to further the chemical sciences}, volume = {2014}, journal = {RSC Advances : an international journal to further the chemical sciences}, number = {4}, issn = {2046-2069}, doi = {10.1039/c4ra04437a}, pages = {31123 -- 31129}, year = {2014}, abstract = {New porous materials based on covalently connected monomers are presented. The key step of the synthesis is an acetalisation reaction. In previous years we used acetalisation reactions extensively to build up various molecular rods. Based on this approach, investigations towards porous polymeric materials were conducted by us. Here we wish to present the results of these studies in the synthesis of 1D polyacetals and porous 3D polyacetals. By scrambling experiments with 1D acetals we could prove that exchange reactions occur between different building blocks (evidenced by MALDI-TOF mass spectrometry). Based on these results we synthesized porous 3D polyacetals under the same mild conditions.}, language = {en} }