@article{MutaiHeydenreichThoithietal.2013,
  author    = {Mutai, Peggoty and Heydenreich, Matthias and Thoithi, Grace and Mugumbate, Grace and Chibale, Kelly and Yenesew, Abiy},
  title     = {3-Hydroxyisoflavanones from the stem bark of dalbergia melanoxylon - isolation, antimycobacterial evaluation and molecular docking studies},
  series = {Phytochemistry letters},
  volume    = {6},
  journal   = {Phytochemistry letters},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1874-3900},
  doi       = {10.1016/j.phytol.2013.08.018},
  pages     = {671 -- 675},
  year      = {2013},
  abstract  = {Two new 3-hydroxyisoflavanones, (S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2',7-dimethoxy-2 '',2 ''-dimethylpyrano[5 '',6 '':3',4']isoflavanone (trivial name sophoronol-7-methyl ether) along with two known compounds (dalbergin and formononetin) were isolated from the stem bark of Dalbergia melanoxylon. The structures were elucidated using spectroscopic techniques. Kenusanone F 7-methyl ether showed activity against Mycobacterium tuberculosis, whereas both of the new compounds were inactive against the malaria parasite Plasmodium falciparum at 10 mu g/ml. Docking studies showed that the new compounds kenusanone F 7-methyl ether and sophoronol-7-methyl ether have high affinity for the M. tuberculosis drug target INHA.},
  language  = {en}
}