@article{FruscalzoFrommerLonderoetal.2017,
  author    = {Fruscalzo, Arrigo and Frommer, Julia-Marie and Londero, Ambrogio P. and Henze, Andrea and Schweigert, Florian J. and Nofer, Jerzy-Roch and Steinhard, Johannes and Klockenbusch, Walter and Schmitz, Ralf and Raila, Jens},
  title     = {First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant's outcome},
  series = {Archives of gynecology and obstetrics},
  volume    = {295},
  journal   = {Archives of gynecology and obstetrics},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0932-0067},
  doi       = {10.1007/s00404-017-4338-4},
  pages     = {1157 -- 1165},
  year      = {2017},
  abstract  = {To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight < 10\%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). We found decreased RBP4 in SGA patients that delivered fetuses < 3\% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95\% CI 1.40-1.75) vs 1.62 (95\% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95\% CI 32.3-66.3) vs 62.9 pg/ml (95\% CI 45.2-78.4) and 906 pg/ml (95\% CI 727-1626) vs 1610 pg/ml (95\% CI 1088-212), p < 0.05). First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.},
  language  = {en}
}
@article{SchmiedchenLongardtLouietal.2016,
  author    = {Schmiedchen, Bettina and Longardt, Ann Carolin and Loui, Andrea and Buehrer, Christoph and Raila, Jens and Schweigert, Florian J.},
  title     = {Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants},
  series = {European journal of pediatrics : official organ of the Belgian Pediatric Association},
  volume    = {175},
  journal   = {European journal of pediatrics : official organ of the Belgian Pediatric Association},
  publisher = {Springer},
  address   = {New York},
  issn      = {0340-6199},
  doi       = {10.1007/s00431-015-2647-9},
  pages     = {365 -- 372},
  year      = {2016},
  abstract  = {Despite high-dose vitamin A supplementation of very low birth weight infants (VLBW, <1500 g), their vitamin A status does not improve substantially. Unknown is the impact of urinary retinol excretion on the serum retinol concentration in these infants. Therefore, the effect of high-dose vitamin A supplementation on the urinary vitamin A excretion in VLBW infants was investigated. Sixty-three VLBW infants were treated with vitamin A (5000 IU intramuscular, 3 times/week for 4 weeks); 38 untreated infants were classified as control group. On days 3 and 28 of life, retinol, retinol-binding protein 4 (RBP4), glomerular filtration rate, proteinuria, and Tamm-Horsfall protein were quantified in urine. On day 3 of life, substantial retinol and RBP4 losses were found in both groups, which significantly decreased until day 28. Notwithstanding, the retinol excretion was higher (P<0.01) under vitamin A supplementation as compared to infants of the control group. On day 28 of life, the urinary retinol concentrations were predictive for serum retinol concentrations in the vitamin A treated (P<0.01), but not in the control group (P=0.570). Conclusion: High urinary retinol excretion may limit the vitamin A supplementation efficacy in VLBW infants. Advanced age and thus postnatal kidney maturation seems to be an important contributor in the prevention of urinary retinol losses.},
  language  = {en}
}
@article{KwanbunjanPanprathipPhosatetal.2018,
  author    = {Kwanbunjan, Karunee and Panprathip, Pornpimol and Phosat, Chanchira and Chumpathat, Noppanath and Wechjakwen, Naruemon and Puduang, Somchai and Auyyuenyong, Ratchada and Henkel, Ina and Schweigert, Florian J.},
  title     = {Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk},
  series = {BMC Endocrine Disorders},
  volume    = {18},
  journal   = {BMC Endocrine Disorders},
  publisher = {BMC},
  address   = {London},
  issn      = {1472-6823},
  doi       = {10.1186/s12902-018-0254-2},
  pages     = {7},
  year      = {2018},
  abstract  = {Background: Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and type 2 diabetes mellitus. The objective of this study was to elucidate the relationship between RBP4, TTR, triglyceride (TG) and type 2 diabetes risk in rural Thailand. Results: RBP4 and TTR levels, as well as homeostatic model assessment of insulin resistance (HOMA-IR) values, were significantly elevated among subjects with high triglyceride levels (p < 0.01, p < 0.05, p < 0.05, respectively). Triglyceride levels correlated with RBP4 (r = 0.34, p < 0.001) and TTR (r= 0.26, p < 0.01) levels, as well as HOMA-IR values (r= 0.16, p < 0.05). After adjustment for age and gender, the risk of hypertriglyceridemia was 3.7 times greater (95\% Cl =1.42 -9.73, p = 0.008) in the highest RBP4 tertile as compared to the lowest tertile. Similarly, the highest TTR and HOMA-IR tertiles had greater risk of hypertriglyceridemia at 3.5 (95\% Cl = 1.30-9.20, p = 0.01) and 3.6 (95\% CI = 1.33- 9.58, p = 0.01) times higher than the respective lowest tertiles. The correlation between TTR and blood glucose was statistically significant (r 0.18, p < 0.05), but not found this relationship in RBP4. Conclusions: The associations of RBP4 and TTR with hypertriglyceridemia and insulin resistance may have important implications for the risk of heart disease and stroke.},
  language  = {en}
}