@article{NeuberSchumacherGulbinsetal.2017,
  author    = {Neuber, Corinna and Schumacher, Fabian and Gulbins, Erich and Kleuser, Burkhard},
  title     = {Mass Spectrometric Determination of Fatty Aldehydes Exemplified by Monitoring the Oxidative Degradation of (2E)-Hexadecenal in HepG2 Cell Lysates},
  series = {Lipidomics},
  volume    = {125},
  journal   = {Lipidomics},
  publisher = {Humana Press},
  address   = {Totowa},
  isbn      = {978-1-4939-6946-3},
  issn      = {0893-2336},
  doi       = {10.1007/978-1-4939-6946-3_10},
  pages     = {147 -- 158},
  year      = {2017},
  abstract  = {Within the last few decades, liquid chromatography-mass spectrometry (LC-MS) has become a preferred method for manifold issues in analytical biosciences, given its high selectivity and sensitivity. However, the analysis of fatty aldehydes, which are important components of cell metabolism, remains challenging. Usually, chemical derivatization prior to MS detection is required to enhance ionization efficiency. In this regard, the coupling of fatty aldehydes to hydrazines like 2,4-dinitrophenylhydrazine (DNPH) is a common approach. Additionally, hydrazones readily react with fatty aldehydes to form stable derivatives, which can be easily separated using high-performance liquid chromatography (HPLC) and subsequently detected by MS. Here, we exemplarily present the quantification of the long-chain fatty aldehyde (2E)-hexadecenal, a break-down product of the bioactive lipid sphingosine 1-phosphate (S1P), after derivatization with 2-diphenylacetyl-1,3-indandione-1-hydrazone (DAIH) via isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight (ESI-QTOF) MS. Moreover, we show that the addition of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) as a coupling agent allows for simultaneous determination of fatty aldehydes and fatty acids as DAIH derivatives. Taking advantage of this, we describe in detail how to monitor the degradation of (2E)-hexadecenal and the concurrent formation of its oxidation product (2E)-hexadecenoic acid in lysates of human hepatoblastoma (HepG2) cells within this chapter.},
  language  = {en}
}
@article{DugWeidlingSogomonyanetal.2020,
  author    = {Dug, Mehmed and Weidling, Stefan and Sogomonyan, Egor and Jokic, Dejan and Krstić, Miloš},
  title     = {Full error detection and correction method applied on pipelined structure using two approaches},
  series = {Journal of circuits, systems and computers},
  volume    = {29},
  journal   = {Journal of circuits, systems and computers},
  number    = {13},
  publisher = {World Scientific},
  address   = {Singapore},
  issn      = {0218-1266},
  doi       = {10.1142/S0218126620502187},
  pages     = {15},
  year      = {2020},
  abstract  = {In this paper, two approaches are evaluated using the Full Error Detection and Correction (FEDC) method for a pipelined structure. The approaches are referred to as Full Duplication with Comparison (FDC) and Concurrent Checking with Parity Prediction (CCPP). Aforementioned approaches are focused on the borderline cases of FEDC method which implement Error Detection Circuit (EDC) in two manners for the purpose of protection of combinational logic to address the soft errors of unspecified duration. The FDC approach implements a full duplication of the combinational circuit, as the most complex and expensive implementation of the FEDC method, and the CCPP approach implements only the parity prediction bit, being the simplest and cheapest technique, for soft error detection. Both approaches are capable of detecting soft errors in the combinational logic, with single faults being injected into the design. On the one hand, the FDC approach managed to detect and correct all injected faults while the CCPP approach could not detect multiple faults created at the output of combinational circuit. On the other hand, the FDC approach leads to higher power consumption and area increase compared to the CCPP approach.},
  language  = {en}
}