@article{BoeckerSchlierHolzHohmetal.2017,
  author    = {Boecker-Schlier, Regina and Holz, Nathalie E. and Hohm, Erika and Zohsel, Katrin and Blomeyer, Dorothea and Buchmann, Arlette F. and Baumeister, Sarah and Wolf, Isabella and Esser, G{\"u}nter and Schmidt, Martin H. and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred},
  title     = {Association between pubertal stage at first drink and neural reward processing in early adulthood},
  series = {Addiction biology},
  volume    = {22},
  journal   = {Addiction biology},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {1355-6215},
  doi       = {10.1111/adb.12413},
  pages     = {1402 -- 1415},
  year      = {2017},
  abstract  = {Puberty is a critical time period during human development. It is characterized by high levels of risk-taking behavior, such as increased alcohol consumption, and is accompanied by various neurobiological changes. Recent studies in animals and humans have revealed that the pubertal stage at first drink (PSFD) significantly impacts drinking behavior in adulthood. Moreover, neuronal alterations of the dopaminergic reward system have been associated with alcohol abuse or addiction. This study aimed to clarify the impact of PSFD on neuronal characteristics of reward processing linked to alcohol-related problems. One hundred sixty-eight healthy young adults from a prospective study covering 25 years participated in a monetary incentive delay task measured with simultaneous EEG-fMRI. PSFD was determined according to the age at menarche or Tanner stage of pubertal development, respectively. Alcohol-related problems in early adulthood were assessed with the Alcohol Use Disorder Identification Test (AUDIT). During reward anticipation, decreased fMRI activation of the frontal cortex and increased preparatory EEG activity (contingent negative variation) occurred with pubertal compared to postpubertal first alcohol intake. Moreover, alcohol-related problems during early adulthood were increased in pubertal compared to postpubertal beginners, which was mediated by neuronal activation of the right medial frontal gyrus. At reward delivery, increased fMRI activation of the left caudate and higher feedback-related EEG negativity were detected in pubertal compared to postpubertal beginners. Together with animal findings, these results implicate PSFD as a potential modulator of psychopathology, involving altered reward anticipation. Both PSFD timing and reward processing might thus be potential targets for early prevention and intervention.},
  language  = {en}
}
@article{BuchmannZohselBlomeyeretal.2014,
  author    = {Buchmann, Arlette F. and Zohsel, Katrin and Blomeyer, Dorothea and Hohm, Erika and Hohmann, Sarah and Jennen-Steinmetz, Christine and Treutlein, Jens and Becker, Katja and Banaschewski, Tobias and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Poustka, Luise and Zimmermann, Ulrich S. and Laucht, Manfred},
  title     = {Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults},
  series = {Psychopharmacology},
  volume    = {231},
  journal   = {Psychopharmacology},
  number    = {16},
  publisher = {Springer},
  address   = {New York},
  issn      = {0033-3158},
  doi       = {10.1007/s00213-014-3484-7},
  pages     = {3089 -- 3097},
  year      = {2014},
  abstract  = {Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal life, is the seven-repeat allele of the dopamine D4 receptor (DRD4) gene. The present investigation concentrated on the interplay of prenatal maternal stress and DRD4 genotype in predicting self-reported aggression in young adults. As disruption of the hypothalamic-pituitary-adrenal system has been discussed as a pathophysiological pathway to aggression, cortisol stress reactivity was additionally examined. As part of an epidemiological cohort study, prenatal maternal stress was assessed by maternal interview 3 months after childbirth. Between the ages of 19 and 23 years, 298 offspring (140 males, 158 females) completed the Young Adult Self-Report to measure aggressive behavior and were genotyped for the DRD4 gene. At 19 years, 219 participants additionally underwent the Trier Social Stress Test to determine cortisol reactivity. Extending earlier findings with respect to childhood antisocial behavior, the results revealed that, under conditions of higher prenatal maternal stress, carriers of the DRD4 seven-repeat allele displayed more aggression in adulthood (p = 0.032). Moreover, the same conditions which seemed to promote aggression were found to predict attenuated cortisol secretion (p = 0.028). This is the first study to indicate a long-term impact of prenatal stress exposure on the cortisol stress response depending on DRD4 genotype.},
  language  = {en}
}
@article{HeinrichBuchmannZohseletal.2015,
  author    = {Heinrich, Angela and Buchmann, Arlette F. and Zohsel, Katrin and Dukal, Helene and Frank, Josef and Treutlein, Jens and Nieratschker, Vanessa and Witt, Stephanie H. and Brandeis, Daniel and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred and Rietschel, Marcella},
  title     = {Alterations of Glucocorticoid Receptor Gene Methylation in Externalizing Disorders During Childhood and Adolescence},
  series = {Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man},
  volume    = {45},
  journal   = {Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man},
  number    = {5},
  publisher = {Springer},
  address   = {New York},
  issn      = {0001-8244},
  doi       = {10.1007/s10519-015-9721-y},
  pages     = {529 -- 536},
  year      = {2015},
  abstract  = {Epigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders might occur.},
  language  = {en}
}
@article{HohmLauchtZohseletal.2017,
  author    = {Hohm, Erika and Laucht, Manfred and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias},
  title     = {Resilienz und Ressourcen im Verlauf der Entwicklung},
  series = {Kindheit und Entwicklung},
  volume    = {26},
  journal   = {Kindheit und Entwicklung},
  publisher = {Hogrefe},
  address   = {G{\"o}ttingen},
  issn      = {0942-5403},
  doi       = {10.1026/0942-5403/a000236},
  pages     = {230 -- 239},
  year      = {2017},
  abstract  = {Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen besch{\"a}ftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines famili{\"a}ren Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen k{\"o}nnen. Eine besondere Rolle kommt dabei positiven fr{\"u}hen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese sch{\"u}tzen Risikokinder davor, eine ung{\"u}nstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ung{\"u}nstiger „Startbedingungen" positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen erm{\"o}glichen es Risikokindern auch unter widrigen Lebensumst{\"a}nden (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverh{\"a}ltnissen) erfolgreich zu bestehen. Dar{\"u}ber hinaus zeigt die Arbeit, dass Resilienz ein Pers{\"o}nlichkeitsmerkmal ist, das ab dem fr{\"u}hen Erwachsenenalter eine hohe Stabilit{\"a}t besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.},
  language  = {de}
}
@misc{HohmLauchtZohseletal.2017,
  author    = {Hohm, Erika and Laucht, Manfred and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias},
  title     = {Resilienz und Ressourcen im Verlauf der Entwicklung},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {608},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-43307},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-433072},
  pages     = {230 -- 239},
  year      = {2017},
  abstract  = {Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen besch{\"a}ftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines famili{\"a}ren Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen k{\"o}nnen. Eine besondere Rolle kommt dabei positiven fr{\"u}hen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese sch{\"u}tzen Risikokinder davor, eine ung{\"u}nstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ung{\"u}nstiger „Startbedingungen" positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen erm{\"o}glichen es Risikokindern auch unter widrigen Lebensumst{\"a}nden (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverh{\"a}ltnissen) erfolgreich zu bestehen. Dar{\"u}ber hinaus zeigt die Arbeit, dass Resilienz ein Pers{\"o}nlichkeitsmerkmal ist, das ab dem fr{\"u}hen Erwachsenenalter eine hohe Stabilit{\"a}t besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.},
  language  = {de}
}
@article{HohmZohselSchmidtetal.2017,
  author    = {Hohm, Erika and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred},
  title     = {Beeintr{\"a}chtigter Start ins Leben},
  series = {Kindheit und Entwicklung},
  volume    = {26},
  journal   = {Kindheit und Entwicklung},
  publisher = {Hogrefe},
  address   = {G{\"o}ttingen},
  issn      = {0942-5403},
  doi       = {10.1026/0942-5403/a000234},
  pages     = {210 -- 220},
  year      = {2017},
  abstract  = {Postpartale Depressionen sind h{\"a}ufige und schwerwiegende psychische Erkrankungen mit ung{\"u}nstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die fr{\"u}he Mutter-Kind-Interaktion. {\"U}ber die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder M{\"u}tter konnten mit 25 Jahren untersucht werden. Beeintr{\"a}chtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver M{\"u}tter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives m{\"u}tterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualit{\"a}t der Mutter-Kind-Interaktion f{\"u}r die Entwicklung von Risikokindern.},
  language  = {de}
}
@misc{HohmZohselSchmidtetal.2017,
  author    = {Hohm, Erika and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred},
  title     = {Beeintr{\"a}chtigter Start ins Leben},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {692},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-43340},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-433406},
  pages     = {37},
  year      = {2017},
  abstract  = {Postpartale Depressionen sind h{\"a}ufige und schwerwiegende psychische Erkrankungen mit ung{\"u}nstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die fr{\"u}he Mutter-Kind-Interaktion. {\"U}ber die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder M{\"u}tter konnten mit 25 Jahren untersucht werden. Beeintr{\"a}chtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver M{\"u}tter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives m{\"u}tterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualit{\"a}t der Mutter-Kind-Interaktion f{\"u}r die Entwicklung von Risikokindern.},
  language  = {de}
}
@article{HohmannZohselBuchmannetal.2016,
  author    = {Hohmann, Sarah and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Holz, Nathalie and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Rietschel, Marcella and Witt, Stephanie H. and Schmidt, Martin H. and Esser, G{\"u}nter and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Hohm, Erika and Laucht, Manfred},
  title     = {Interacting effect of MAOA genotype and maternal prenatal smoking on aggressive behavior in young adulthood},
  series = {Journal of neural transmission},
  volume    = {123},
  journal   = {Journal of neural transmission},
  publisher = {Springer},
  address   = {Wien},
  issn      = {0300-9564},
  doi       = {10.1007/s00702-016-1582-x},
  pages     = {885 -- 894},
  year      = {2016},
  abstract  = {Findings on the etiology of aggressive behavior have provided evidence for an effect both of genetic factors, such as variation in the monoamine oxidase A (MAOA) gene, and adverse environmental factors. Recent studies have supported the existence of gene × environment interactions, with early experiences playing a key role. In the present study, the effects of prenatal nicotine exposure, MAOA genotype and their interaction on aggressive behavior during young adulthood were examined. In a sample of 272 young adults (129 males, 143 females) from an epidemiological cohort study, smoking during pregnancy was measured with a standardized parent interview at the offspring's age of 3 months. Aggressive behavior was assessed between the ages of 19 and 25 years using the Young Adult Self-Report. DNA was genotyped for the MAOA 5\&\#8242; untranslated region variable number of tandem repeats polymorphism (VNTR). Results revealed a significant interaction between MAOA and smoking during pregnancy, indicating higher levels of aggressive behavior in young adults carrying the MAOA low-expressing genotype who had experienced prenatal nicotine exposure (n = 8, p = .025). In contrast, in carriers of the MAOA high-expressing genotype, maternal smoking during pregnancy had no effect on aggressive behavior during young adulthood (n = 20, p = .145). This study extends earlier findings demonstrating an interaction between MAOA genotype and prenatal nicotine exposure on aggressive behavior into young adulthood. The results point to the long-term adverse effects of smoking during pregnancy on the offspring's mental health, possibly underlining the importance of smoking cessation during pregnancy. According to the nature of the study (particularly sample size and power), analyses are exploratory and results need to be interpreted cautiously.},
  language  = {en}
}
@article{HolzBoeckerSchlierBaumeisteretal.2014,
  author    = {Holz, Nathalie E. and Boecker-Schlier, Regina and Baumeister, Sarah and Hohm, Erika and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Hohmann, Sarah and Wolf, Isabella and Plichta, Michael M. and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred},
  title     = {Effect of prenatal exposure to tobacco smoke on inhibitory control neuroimaging results from a 25-Year prospective study},
  series = {JAMA psychiatry},
  volume    = {71},
  journal   = {JAMA psychiatry},
  number    = {7},
  publisher = {American Veterinary Medical Association},
  address   = {Chicago},
  issn      = {2168-622X},
  doi       = {10.1001/jamapsychiatry.2014.786},
  pages     = {786 -- 796},
  year      = {2014},
  abstract  = {IMPORTANCE: There is accumulating evidence relating maternal smoking during pregnancy to attention-deficit/hyperactivity disorder (ADHD) without elucidating specific mechanisms. Research investigating the neurobiological underpinnings of this disorder has implicated deficits during response inhibition. Attempts to uncover the effect of prenatal exposure to nicotine on inhibitory control may thus be of high clinical importance. MAIN OUTCOMES AND MEASURES: Functional magnetic resonance imaging response, morphometric data, lifetime ADHD symptoms, and novelty seeking. RESULTS: Participants prenatally exposed to nicotine exhibited a weaker response in the anterior cingulate cortex (t(168) = 4.46; peak Montreal Neurological Institute [MNI] coordinates x = -2, y = 20, z = 30; familywise error [FWE]-corrected P = .003), the right inferior frontal gyrus (t(168) = 3.65; peak MNI coordinates x = 44, y = 38, z = 12; FWE-corrected P = .04), the left inferior frontal gyrus (t(168) = 4.09; peak MNI coordinates x = -38, y = 36, z = 8; FWE-corrected P = .009), and the supramarginal gyrus (t(168) = 5.03; peak MNI coordinates x = 64, y = -28, z = 22; FWE-corrected P = .02) during the processing of the NoGo compared to neutral stimuli, while presenting a decreased volume in the right inferior frontal gyrus. These findings were obtained irrespective of the adjustment of confounders, ADHD symptoms, and novelty seeking. There was an inverse relationship between inferior frontal gyrus activity and ADHD symptoms and between anterior cingulate cortex activity and novelty seeking. CONCLUSIONS AND RELEVANCE: These findings point to a functional involvement of prenatal exposure to tobacco smoke in neural alterations similar to ADHD, which underlines the importance of smoking prevention treatments.},
  language  = {en}
}
@article{HolzBoeckerSchlierHohmetal.2015,
  author    = {Holz, Nathalie E. and Boecker-Schlier, Regina and Hohm, Erika and Zohsel, Katrin and Buchmann, Arlette F. and Blomeyer, Dorothea and Jennen-Steinmetz, Christine and Baumeister, Sarah and Hohmann, Sarah and Wolf, Isabella and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred},
  title     = {The Long-Term Impact of Early Life Poverty on Orbitofrontal Cortex Volume in Adulthood: Results from a Prospective Study Over 25 Years},
  series = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  volume    = {40},
  journal   = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  number    = {4},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0893-133X},
  doi       = {10.1038/npp.2014.277},
  pages     = {996 -- 1004},
  year      = {2015},
  abstract  = {Converging evidence has highlighted the association between poverty and conduct disorder (CD) without specifying neurobiological pathways. Neuroimaging research has emphasized structural and functional alterations in the orbitofrontal cortex (OFC) as one key mechanism underlying this disorder. The present study aimed to clarify the long-term influence of early poverty on OFC volume and its association with CD symptoms in healthy participants of an epidemiological cohort study followed since birth. At age 25 years, voxel-based morphometry was applied to study brain volume differences. Poverty (0 = non-exposed (N = 134), I = exposed (N = 33)) and smoking during pregnancy were determined using a standardized parent interview, and information on maternal responsiveness was derived from videotaped mother infant interactions at the age of 3 months. CD symptoms were assessed by diagnostic interview from 8 to 19 years of age. Information on life stress was acquired at each assessment and childhood maltreatment was measured using retrospective self-report at the age of 23 years. Analyses were adjusted for sex, parental psychopathology and delinquency, obstetric adversity, parental education, and current poverty. Individuals exposed to early life poverty exhibited a lower OFC volume. Moreover, we replicated previous findings of increased CD symptoms as a consequence of childhood poverty. This effect proved statistically mediated by OFC volume and exposure to life stress and smoking during pregnancy, but not by childhood maltreatment and maternal responsiveness. These findings underline the importance of studying the impact of early life adversity on brain alterations and highlight the need for programs to decrease income-related disparities.},
  language  = {en}
}