@article{JuerchottGuoCatchpoleetal.2011, author = {Juerchott, Kathrin and Guo, Ke-Tai and Catchpole, Gareth and Feher, Kristen and Willmitzer, Lothar and Schichor, Christian and Selbig, Joachim}, title = {Comparison of metabolite profiles in U87 glioma cells and mesenchymal stem cells}, series = {Biosystems : journal of biological and information processing sciences}, volume = {105}, journal = {Biosystems : journal of biological and information processing sciences}, number = {2}, publisher = {Elsevier}, address = {Oxford}, issn = {0303-2647}, doi = {10.1016/j.biosystems.2011.05.005}, pages = {130 -- 139}, year = {2011}, abstract = {Gas chromatography-mass spectrometry (GC-MS) profiles were generated from U87 glioma cells and human mesenchymal stem cells (hMSC). 37 metabolites representing glycolysis intermediates, TCA cycle metabolites, amino acids and lipids were selected for a detailed analysis. The concentrations of these. metabolites were compared and Pearson correlation coefficients were used to calculate the relationship between pairs of metabolites. Metabolite profiles and correlation patterns differ significantly between the two cell lines. These profiles can be considered as a signature of the underlying biochemical system and provide snap-shots of the metabolism in mesenchymal stem cells and tumor cells.}, language = {en} }