@article{BaldKellerKopyra2014, author = {Bald, Ilko and Keller, Adrian and Kopyra, Janina}, title = {On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy}, series = {RSC Advances : an international journal to further the chemical sciences}, volume = {4}, journal = {RSC Advances : an international journal to further the chemical sciences}, number = {13}, publisher = {Royal Society of Chemistry}, issn = {2046-2069}, doi = {10.1039/C3RA46735J}, pages = {6825 -- 6829}, year = {2014}, abstract = {Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA.}, language = {en} } @misc{BaldKopyraKeller2014, author = {Bald, Ilko and Kopyra, Janina and Keller, Adrian}, title = {On the role of fluoro-substituted nucleosides in DNA radiosensitization for tumor radiation therapy}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-73412}, pages = {6825 -- 6829}, year = {2014}, abstract = {Gemcitabine (2′,2′-difluorocytidine) is a well-known radiosensitizer routinely applied in concomitant chemoradiotherapy. During irradiation of biological media with high-energy radiation secondary low-energy (<10 eV) electrons are produced that can directly induce chemical bond breakage in DNA by dissociative electron attachment (DEA). Here, we investigate and compare DEA to the three molecules 2′-deoxycytidine, 2′-deoxy-5-fluorocytidine, and gemcitabine. Fluorination at specific molecular sites, i.e., nucleobase or sugar moiety, is found to control electron attachment and subsequent dissociation pathways. The presence of two fluorine atoms at the sugar ring results in more efficient electron attachment to the sugar moiety and subsequent bond cleavage. For the formation of the dehydrogenated nucleobase anion, we obtain an enhancement factor of 2.8 upon fluorination of the sugar, whereas the enhancement factor is 5.5 when the nucleobase is fluorinated. The observed fragmentation reactions suggest enhanced DNA strand breakage induced by secondary electrons when gemcitabine is incorporated into DNA.}, language = {en} } @misc{BubeckAertsdeMoeletal.2016, author = {Bubeck, Philip and Aerts, Jeroen C. J. H. and de Moel, Hans and Kreibich, Heidi}, title = {Preface}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {609}, issn = {1866-8372}, doi = {10.25932/publishup-41238}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-412387}, pages = {6}, year = {2016}, abstract = {kein abstract}, language = {en} } @article{CabezaMuellerPereyraetal.2018, author = {Cabeza, Sandra and M{\"u}ller, Bernd R. and Pereyra, Ricio and Fernandez, Ricardo and Gonzalez-Doncel, Gaspar and Bruno, Giovanni}, title = {Evidence of damage evolution during creep of Al-Mg alloy using synchrotron X-ray refraction}, series = {Journal of applied crystallography}, volume = {51}, journal = {Journal of applied crystallography}, publisher = {International Union of Crystallography}, address = {Chester}, issn = {1600-5767}, doi = {10.1107/S1600576718001449}, pages = {420 -- 427}, year = {2018}, abstract = {In order to provide further evidence of damage mechanisms predicted by the recent solid-state transformation creep (SSTC) model, direct observation of damage accumulation during creep of Al-3.85Mg was made using synchrotron X-ray refraction. X-ray refraction techniques detect the internal specific surface (i.e. surface per unit volume) on a length scale comparable to the specimen size, but with microscopic sensitivity. A significant rise in the internal specific surface with increasing creep time was observed, providing evidence for the creation of a fine grain substructure, as predicted by the SSTC model. This substructure was also observed by scanning electron microscopy.}, language = {en} } @misc{GeigerFrielerLevermann2017, author = {Geiger, Tobias and Frieler, Katja and Levermann, Anders}, title = {Reply to Comment on: High-income does not protect against hurricane losses (Environmental research letters. - 12 (2017))}, series = {Environmental research letters}, volume = {12}, journal = {Environmental research letters}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/aa88d6}, pages = {2}, year = {2017}, abstract = {Recently a multitude of empirically derived damage models have been applied to project future tropical cyclone (TC) losses for the United States. In their study (Geiger et al 2016 Environ. Res. Lett. 11 084012) compared two approaches that differ in the scaling of losses with socio-economic drivers: the commonly-used approach resulting in a sub-linear scaling of historical TC losses with a nation's affected gross domestic product (GDP), and the disentangled approach that shows a sub-linear increase with affected population and a super-linear scaling of relative losses with per capita income. Statistics cannot determine which approach is preferable but since process understanding demands that there is a dependence of the loss on both GDP per capita and population, an approach that accounts for both separately is preferable to one which assumes a specific relation between the two dependencies. In the accompanying comment, Rybski et al argued that there is no rigorous evidence to reach the conclusion that high-income does not protect against hurricane losses. Here we affirm that our conclusion is drawn correctly and reply to further remarks raised in the comment, highlighting the adequateness of our approach but also the potential for future extension of our research.}, language = {en} } @article{GeigerFrielerLevermann2016, author = {Geiger, Tobias and Frieler, Katja and Levermann, Anders}, title = {High-income does not protect against hurricane losses}, series = {Environmental research letters}, volume = {11}, journal = {Environmental research letters}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/11/8/084012}, pages = {10}, year = {2016}, abstract = {Damage due to tropical cyclones accounts for more than 50\% of all meteorologically-induced economic losses worldwide. Their nominal impact is projected to increase substantially as the exposed population grows, per capita income increases, and anthropogenic climate change manifests. So far, historical losses due to tropical cyclones have been found to increase less than linearly with a nation's affected gross domestic product (GDP). Here we show that for the United States this scaling is caused by a sub-linear increase with affected population while relative losses scale super-linearly with per capita income. The finding is robust across a multitude of empirically derived damage models that link the storm's wind speed, exposed population, and per capita GDP to reported losses. The separation of both socio-economic predictors strongly affects the projection of potential future hurricane losses. Separating the effects of growth in population and per-capita income, per hurricane losses with respect to national GDP are projected to triple by the end of the century under unmitigated climate change, while they are estimated to decrease slightly without the separation.}, language = {en} } @article{KalkuhlWenz2020, author = {Kalkuhl, Matthias and Wenz, Leonie}, title = {The impact of climate conditions on economic production}, series = {Journal of Environmental Economics and Management}, volume = {103}, journal = {Journal of Environmental Economics and Management}, publisher = {Elsevier}, address = {San Diego}, issn = {0095-0696}, doi = {10.1016/j.jeem.2020.102360}, pages = {20}, year = {2020}, abstract = {We present a novel data set of subnational economic output, Gross Regional Product (GRP), for more than 1500 regions in 77 countries that allows us to empirically estimate historic climate impacts at different time scales. Employing annual panel models, long-difference regressions and cross-sectional regressions, we identify effects on productivity levels and productivity growth. We do not find evidence for permanent growth rate impacts but we find robust evidence that temperature affects productivity levels considerably. An increase in global mean surface temperature by about 3.5°C until the end of the century would reduce global output by 7-14\% in 2100, with even higher damages in tropical and poor regions. Updating the DICE damage function with our estimates suggests that the social cost of carbon from temperature-induced productivity losses is on the order of 73-142\$/tCO2 in 2020, rising to 92-181\$/tCO2 in 2030. These numbers exclude non-market damages and damages from extreme weather events or sea-level rise.}, language = {en} } @misc{KienzlerPechKreibichetal.2014, author = {Kienzler, Sarah and Pech, I. and Kreibich, Heidi and M{\"u}ller, M. and Thieken, Annegret}, title = {After the extreme flood in 2002}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe}, number = {488}, issn = {1866-8372}, doi = {10.25932/publishup-40805}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-408056}, pages = {505 -- 526}, year = {2014}, abstract = {In the aftermath of the severe flooding in Central Europe in August 2002, a number of changes in flood policies were launched in Germany and other European countries, aiming at improved risk management. The question arises as to whether these changes have already had an impact on the residents' ability to cope with floods, and whether flood-affected private households are now better prepared than they were in 2002. Therefore, computer-aided telephone interviews with private households in Germany that suffered from property damage due to flooding in 2005, 2006, 2010 or 2011 were performed and analysed with respect to flood awareness, precaution, preparedness and recovery. The data were compared to a similar investigation conducted after the flood in 2002. After the flood in 2002, the level of private precautions taken increased considerably. One contributing factor is the fact that, in general, a larger proportion of people knew that they were at risk of flooding. The best level of precaution was found before the flood events in 2006 and 2011. The main reason for this might be that residents had more experience with flooding than residents affected in 2005 or 2010. Yet, overall, flood experience and knowledge did not necessarily result in building retrofitting or flood-proofing measures, which are considered as mitigating damages most effectively. Hence, investments still need to be stimulated in order to reduce future damage more efficiently. Early warning and emergency responses were substantially influenced by flood characteristics. In contrast to flood-affected people in 2006 or 2011, people affected by flooding in 2005 or 2010 had to deal with shorter lead times and therefore had less time to take emergency measures. Yet, the lower level of emergency measures taken also resulted from the people's lack of flood experience and insufficient knowledge of how to protect themselves. Overall, it was noticeable that these residents suffered from higher losses. Therefore, it is important to further improve early warning systems and communication channels, particularly in hilly areas with rapid-onset flooding.}, language = {en} } @misc{KreibichMuellerSchroeteretal.2017, author = {Kreibich, Heidi and M{\"u}ller, Meike and Schr{\"o}ter, Kai and Thieken, Annegret}, title = {New insights into flood warning reception and emergency response by affected parties}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {659}, issn = {1866-8372}, doi = {10.25932/publishup-41838}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418381}, pages = {18}, year = {2017}, abstract = {Flood damage can be mitigated if the parties at risk are reached by flood warnings and if they know how to react appropriately. To gain more knowledge about warning reception and emergency response of private households and companies, surveys were undertaken after the August 2002 and the June 2013 floods in Germany. Despite pronounced regional differences, the results show a clear overall picture: in 2002, early warnings did not work well; e.g. many households (27 \%) and companies (45 \%) stated that they had not received any flood warnings. Additionally, the preparedness of private households and companies was low in 2002, mainly due to a lack of flood experience. After the 2002 flood, many initiatives were launched and investments undertaken to improve flood risk management, including early warnings and an emergency response in Germany. In 2013, only a small share of the affected households (5 \%) and companies (3 \%) were not reached by any warnings. Additionally, private households and companies were better prepared. For instance, the share of companies which have an emergency plan in place has increased from 10\% in 2002 to 34\% in 2013. However, there is still room for improvement, which needs to be triggered mainly by effective risk and emergency communication. The challenge is to continuously maintain and advance an integrated early warning and emergency response system even without the occurrence of extreme floods.}, language = {en} } @article{LaudanZoellerThieken2020, author = {Laudan, Jonas and Z{\"o}ller, Gert and Thieken, Annegret}, title = {Flash floods versus river floods}, series = {Natural Hazards and Earth System Sciences}, volume = {20}, journal = {Natural Hazards and Earth System Sciences}, publisher = {European Geophysical Society}, address = {Katlenburg-Lindau}, issn = {1684-9981}, doi = {10.5194/nhess-20-999-2020}, pages = {999 -- 1023}, year = {2020}, abstract = {River floods are among the most damaging natural hazards that frequently occur in Germany. Flooding causes high economic losses and impacts many residents. In 2016, several southern German municipalities were hit by flash floods after unexpectedly severe heavy rainfall, while in 2013 widespread river flooding had occurred. This study investigates and compares the psychological impacts of river floods and flash floods and potential consequences for precautionary behaviour. Data were collected using computer-aided telephone interviews that were conducted among flood-affected households around 9 months after each damaging event. This study applies Bayesian statistics and negative binomial regressions to test the suitability of psychological indicators to predict the precaution motivation of individuals. The results show that it is not the particular flood type but rather the severity and local impacts of the event that are crucial for the different, and potentially negative, impacts on mental health. According to the used data, however, predictions of the individual precaution motivation should not be based on the derived psychological indicators - i.e. coping appraisal, threat appraisal, burden and evasion - since their explanatory power was generally low and results are, for the most part, non-significant. Only burden reveals a significant positive relation to planned precaution regarding weak flash floods. In contrast to weak flash floods and river floods, the perceived threat of strong flash floods is significantly lower although feelings of burden and lower coping appraisals are more pronounced. Further research is needed to better include psychological assessment procedures and to focus on alternative data sources regarding floods and the connected precaution motivation of affected residents.}, language = {en} }