@misc{BiterovaEsmaeeliMoghaddamTabalvandaniAlanenetal.2018, author = {Biterova, Ekaterina and Esmaeeli Moghaddam Tabalvandani, Mariam and Alanen, Heli I. and Saaranen, Mirva and Ruddock, Lloyd W.}, title = {Structures of Angptl3 and Angptl4}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1048}, issn = {1866-8372}, doi = {10.25932/publishup-46794}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-467943}, pages = {14}, year = {2018}, abstract = {Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma triglyceride levels and coronary artery disease. The exact function and mechanism of action of both proteins remains to be elucidated, however, mutations in these proteins results in up to 34\% reduction in coronary artery disease and inhibition of function results in reduced plasma triglyceride levels. Here we report the crystal structures of the fibrinogen-like domains of both proteins. These structures offer new insights into the reported loss of function mutations, the mechanisms of action of the proteins and open up the possibility for the rational design of low molecular weight inhibitors for intervention in coronary artery disease.}, language = {en} } @phdthesis{Ganschow2021, author = {Ganschow, Constantin Alexander}, title = {Die Konversion im Asylverfahren}, series = {Acta Iuridica Universitatis Potsdamiensis}, journal = {Acta Iuridica Universitatis Potsdamiensis}, number = {7}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-509-5}, issn = {2199-9686}, doi = {10.25932/publishup-50581}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-505819}, school = {Universit{\"a}t Potsdam}, pages = {230}, year = {2021}, abstract = {Der Verfasser besch{\"a}ftigt sich mit der Frage des Glaubens{\"u}bertritts in einem Asylverfahren. Dabei nimmt er Zeitpunkt, Art und Umst{\"a}nde des Religionswechsels in den Blick. Ferner untersucht er, wie die sogenannte Konversion von den zust{\"a}ndigen Beh{\"o}rden und Gerichten zu behandeln und zu bewerten ist. Einf{\"u}hrend gibt er einen {\"U}berblick zum v{\"o}lkerrechtlichen Schutz der Religions- und Weltanschauungsfreiheit sowie typischen Gef{\"a}hrdungslagen. {\"U}berdies befasst er sich mit den Rechtsgrundlagen des Asyl- und Fl{\"u}chtlingsschutzrechts und stellt Verbindungen zum Flucht- und Verfolgungsgrund der Religion her. Schwerpunkt bildet die Untersuchung der Verfahrensstadien, in denen die Konversion relevant wird. Dabei ber{\"u}cksichtigt der Verfasser die nationale und europ{\"a}ische Rechtsprechung. Von besonderer Bedeutung sind die Ausf{\"u}hrungen zum Zusammenspiel von staatlichen Ermittlungspflichten und Mitwirkungsgeboten von Asylantragstellenden, wobei den Besonderheiten des grund- und menschenrechtlichen Mehrebenensystems Rechnung getragen wird. Zentral sind ferner die Ausf{\"u}hrungen zum Umgang mit Taufurkunden und sonstigen Bescheinigungen {\"u}ber die religi{\"o}se {\"U}berzeugung. Besonderes Gewicht liegt auf der verfassungsrechtlichen Stellung der Religionsgemeinschaften und der Frage, ob die Entscheidung einer Religionsgemeinschaft, ein neues Mitglied aufzunehmen, die Beh{\"o}rde im Asylverfahren bindet. Diesem Problem widmet sich der Verfasser unter Heranziehung der relevanten Literaturstimmen und einschl{\"a}gigen Rechtsprechung. Der rechtswissenschaftliche Beitrag bietet den beteiligten Akteuren nicht nur eine Einf{\"u}hrung in das Themengebiet des Glaubens{\"u}bertritts im Asylverfahren, sondern gibt den Lesenden auch eine praxistaugliche Handlungsunterst{\"u}tzung rund um die wichtigsten Fragen einer Konversion im Asylverfahren an die Hand. Praktische Bez{\"u}ge entstehen beispielsweise dadurch, dass wichtige Impulse und Empfehlungen f{\"u}r eine gleichermaßen moderne, rechtsstaatliche und grundrechtsorientierte Verfahrensf{\"u}hrung entwickelt werden.}, language = {de} } @article{GomezZapataZafrirPittoreetal.2022, author = {Gomez Zapata, Juan Camilo and Zafrir, Raquel and Pittore, Massimiliano and Merino, Yvonne}, title = {Towards a sensitivity analysis in seismic risk with probabilistic building exposure models}, series = {ISPRS International Journal of Geo-Information}, volume = {11}, journal = {ISPRS International Journal of Geo-Information}, number = {2}, publisher = {MDPI}, address = {Basel}, issn = {2220-9964}, doi = {10.3390/ijgi11020113}, pages = {38}, year = {2022}, abstract = {Efforts have been made in the past to enhance building exposure models on a regional scale with increasing spatial resolutions by integrating different data sources. This work follows a similar path and focuses on the downscaling of the existing SARA exposure model that was proposed for the residential building stock of the communes of Valparaiso and Vina del Mar (Chile). Although this model allowed great progress in harmonising building classes and characterising their differential physical vulnerabilities, it is now outdated, and in any case, it is spatially aggregated over large administrative units. Hence, to more accurately consider the impact of future earthquakes on these cities, it is necessary to employ more reliable exposure models. For such a purpose, we propose updating this existing model through a Bayesian approach by integrating ancillary data that has been made increasingly available from Volunteering Geo-Information (VGI) activities. Its spatial representation is also optimised in higher resolution aggregation units that avoid the inconvenience of having incomplete building-by-building footprints. A worst-case earthquake scenario is presented to calculate direct economic losses and highlight the degree of uncertainty imposed by exposure models in comparison with other parameters used to generate the seismic ground motions within a sensitivity analysis. This example study shows the great potential of using increasingly available VGI to update worldwide building exposure models as well as its importance in scenario-based seismic risk assessment.}, language = {en} } @article{HoeseWyschkonMoraskeetal.2016, author = {H{\"o}se, Anna and Wyschkon, Anne and Moraske, Svenja and Eggeling, Marie and Quandte, Sabine and Kohn, Juliane and Poltz, Nadine and von Aster, Michael G. and Esser, G{\"u}nter}, title = {Prevention of dyslexia short-term and intermediate effects of promoting phonological awareness and letter-sound correspondence with at-risk preschool children}, series = {Zeitschrift f{\~A}¼r Kinder- und Jugendpsychiatrie und Psychotherapie}, volume = {44}, journal = {Zeitschrift f{\~A}¼r Kinder- und Jugendpsychiatrie und Psychotherapie}, publisher = {Hogrefe}, address = {Bern}, issn = {1422-4917}, doi = {10.1024/1422-4917/a000456}, pages = {377 -- 391}, year = {2016}, abstract = {Objective: This study assesses the short-term and intermediate effects of preschool training stimulating phonological awareness and letter-sound correspondence for children at risk of developing dyslexia. Moreover, we examined whether training reduced the frequency of subsequent dyslexic problems. Method: 25 children at risk of developing dyslexia were trained with Horen, Lauschen, Lernen 1 und 2 (Kuspert \& Schneider, 2008; Plume \& Schneider, 2004) by their kindergarten teachers and were compared with 60 untrained at-risk children. Results:The training revealed a significant short-term effect: The phonological awareness of trained at-risk children increased significantly over that of untrained at-risk children. However, there were no differences in phonological awareness, spelling, and reading ability between the first-graders in the training and control group. Furthermore, reading problems were reduced in the training group. Conclusions: In the future, phonological awareness as well as additional predictors should be included when identifying children vulnerable to developing dyslexia. Moreover, in order to prevent dyslexia, additional prerequisite deficits need to be identified, alleviated, and their effects evaluated.}, language = {de} } @article{KamaliJahanbakhshiDogaruetal.2022, author = {Kamali, Bahareh and Jahanbakhshi, Farshid and Dogaru, Diana and Dietrich, J{\"o}rg and Nendel, Claas and AghaKouchak, Amir}, title = {Probabilistic modeling of crop-yield loss risk under drought: a spatial showcase for sub-Saharan Africa}, series = {Environmental research letters}, volume = {17}, journal = {Environmental research letters}, number = {2}, publisher = {IOP Publishing}, address = {Bristol}, issn = {1748-9326}, doi = {10.1088/1748-9326/ac4ec1}, pages = {15}, year = {2022}, abstract = {Assessing the risk of yield loss in African drought-affected regions is key to identify feasible solutions for stable crop production. Recent studies have demonstrated that Copula-based probabilistic methods are well suited for such assessment owing to reasonably inferring important properties in terms of exceedance probability and joint dependence of different characterization. However, insufficient attention has been given to quantifying the probability of yield loss and determining the contribution of climatic factors. This study applies the Copula theory to describe the dependence between drought and crop yield anomalies for rainfed maize, millet, and sorghum crops in sub-Saharan Africa (SSA). The environmental policy integrated climate model, calibrated with Food and Agriculture Organization country-level yield data, was used to simulate yields across SSA (1980-2012). The results showed that the severity of yield loss due to drought had a higher magnitude than the severity of drought itself. Sensitivity analysis to identify factors contributing to drought and high-temperature stresses for all crops showed that the amount of precipitation during vegetation and grain filling was the main driver of crop yield loss, and the effect of temperature was stronger for sorghum than for maize and millet. The results demonstrate the added value of probabilistic methods for drought-impact assessment. For future studies, we recommend looking into factors influencing drought and high-temperature stresses as individual/concurrent climatic extremes.}, language = {en} } @phdthesis{Kox2018, author = {Kox, Thomas}, title = {Perception and use of uncertainty in severe weather warnings}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-411541}, school = {Universit{\"a}t Potsdam}, pages = {154}, year = {2018}, abstract = {Uncertainty is an essential part of atmospheric processes and thus inherent to weather forecasts. Nevertheless, weather forecasts and warnings are still predominately issued as deterministic (yes or no) forecasts, although research suggests that providing weather forecast users with additional information about the forecast uncertainty can enhance the preparation of mitigation measures. Communicating forecast uncertainty would allow for a provision of information on possible future events at an earlier time. The desired benefit is to enable the users to start with preparatory protective action at an earlier stage of time based on the their own risk assessment and decision threshold. But not all users have the same threshold for taking action. In the course of the project WEXICOM ('Wetterwarnungen: Von der Extremereignis-Information zu Kommunikation und Handlung') funded by the Deutscher Wetterdienst (DWD), three studies were conducted between the years 2012 and 2016 to reveal how weather forecasts and warnings are reflected in weather-related decision-making. The studies asked which factors influence the perception of forecasts and the decision to take protective action and how forecast users make sense of probabilistic information and the additional lead time. In a first exploratory study conducted in 2012, members of emergency services in Germany were asked questions about how weather warnings are communicated to professional endusers in the emergency community and how the warnings are converted into mitigation measures. A large number of open questions were selected to identify new topics of interest. The questions covered topics like users' confidence in forecasts, their understanding of probabilistic information as well as their lead time and decision thresholds to start with preparatory mitigation measures. Results show that emergency service personnel generally have a good sense of uncertainty inherent in weather forecasts. Although no single probability threshold could be identified for organisations to start with preparatory mitigation measures, it became clear that emergency services tend to avoid forecasts based on low probabilities as a basis for their decisions. Based on this findings, a second study conducted with residents of Berlin in 2014 further investigated the question of decision thresholds. The survey questions related to the topics of the perception of and prior experience with severe weather, trustworthiness of forecasters and confidence in weather forecasts, and socio-demographic and social-economic characteristics. Within the questionnaire a scenario was created to determine individual decision thresholds and see whether subgroups of the sample lead to different thresholds. The results show that people's willingness to act tends to be higher and decision thresholds tend to be lower if the expected weather event is more severe or the property at risk is of higher value. Several influencing factors of risk perception have significant effects such as education, housing status and ability to act, whereas socio-demographic determinants alone are often not sufficient to fully grasp risk perception and protection behaviour. Parallel to the quantitative studies, an interview study was conducted with 27 members of German civil protection between 2012 and 2016. The results show that the latest developments in (numerical) weather forecasting do not necessarily fit the current practice of German emergency services. These practices are mostly carried out on alarms and ground truth in a reactive manner rather than on anticipation based on prognosis or forecasts. As the potential consequences rather than the event characteristics determine protective action, the findings support the call and need for impact-based warnings. Forecasters will rely on impact data and need to learn the users' understanding of impact. Therefore, it is recommended to enhance weather communication not only by improving computer models and observation tools, but also by focusing on the aspects of communication and collaboration. Using information about uncertainty demands awareness about and acceptance of the limits of knowledge, hence, the capabilities of the forecaster to anticipate future developments of the atmosphere and the capabilities of the user to make sense of this information.}, language = {en} } @misc{KreibichMuellerSchroeteretal.2017, author = {Kreibich, Heidi and M{\"u}ller, Meike and Schr{\"o}ter, Kai and Thieken, Annegret}, title = {New insights into flood warning reception and emergency response by affected parties}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {659}, issn = {1866-8372}, doi = {10.25932/publishup-41838}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418381}, pages = {18}, year = {2017}, abstract = {Flood damage can be mitigated if the parties at risk are reached by flood warnings and if they know how to react appropriately. To gain more knowledge about warning reception and emergency response of private households and companies, surveys were undertaken after the August 2002 and the June 2013 floods in Germany. Despite pronounced regional differences, the results show a clear overall picture: in 2002, early warnings did not work well; e.g. many households (27 \%) and companies (45 \%) stated that they had not received any flood warnings. Additionally, the preparedness of private households and companies was low in 2002, mainly due to a lack of flood experience. After the 2002 flood, many initiatives were launched and investments undertaken to improve flood risk management, including early warnings and an emergency response in Germany. In 2013, only a small share of the affected households (5 \%) and companies (3 \%) were not reached by any warnings. Additionally, private households and companies were better prepared. For instance, the share of companies which have an emergency plan in place has increased from 10\% in 2002 to 34\% in 2013. However, there is still room for improvement, which needs to be triggered mainly by effective risk and emergency communication. The challenge is to continuously maintain and advance an integrated early warning and emergency response system even without the occurrence of extreme floods.}, language = {en} } @article{LiStomaLottaetal.2020, author = {Li, Chen and Stoma, Svetlana and Lotta, Luca A. and Warner, Sophie and Albrecht, Eva and Allione, Alessandra and Arp, Pascal P. and Broer, Linda and Buxton, Jessica L. and Boeing, Heiner and Langenberg, Claudia and Codd, Veryan}, title = {Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length}, series = {American Journal of Human Genetics}, volume = {106}, journal = {American Journal of Human Genetics}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, pages = {16}, year = {2020}, abstract = {Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.}, language = {en} } @misc{LiStomaLottaetal.2020, author = {Li, Chen and Stoma, Svetlana and Lotta, Luca A. and Warner, Sophie and Albrecht, Eva and Allione, Alessandra and Arp, Pascal P. and Broer, Linda and Buxton, Jessica L. and Boeing, Heiner and Langenberg, Claudia and Codd, Veryan}, title = {Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {3}, issn = {1866-8372}, doi = {10.25932/publishup-52684}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-526843}, pages = {18}, year = {2020}, abstract = {Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.}, language = {en} } @phdthesis{Meissner2007, author = {Meißner, Frank}, title = {Produktion unter Risiko}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-18810}, school = {Universit{\"a}t Potsdam}, year = {2007}, abstract = {Mit der hier vorliegenden Arbeit wird ein mikro{\"o}konomisches Multiagentenmodell eines Produktionssektors vorgeschlagen. Das Modell folgt einem post-walrasianischem Ungleichgewichtsansatz und beschreibt optimierende Agenten der Produktionsseite. Diese ber{\"u}cksichtigen in probabilistischen Nebenbedingungen Risiken des Cash Flow, die sich aus unsicheren Absatzmengen ergeben. Produzenten stehen in monopolistischer Konkurrenz und lernen durch Beobachten. Wird vorliegendes Modell in ein Totalmodell integriert, so wird es m{\"o}glich, die sich aus der Klimadebatte ergebenden, notwendigen Ver{\"a}nderungen im Investitions- und Produktionsverhalten zu diskutieren und darzustellen.}, language = {de} }