@article{KumarBasuLemkeetal.2016, author = {Kumar, Reddi K. and Basu, Sayantani and Lemke, Horst-Dieter and Jankowski, Joachim and Kratz, Karl and Lendlein, Andreas and Tetali, Sarada D.}, title = {Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells}, series = {Clinical hemorheology and microcirculation : blood flow and vessels}, volume = {61}, journal = {Clinical hemorheology and microcirculation : blood flow and vessels}, publisher = {IOS Press}, address = {Amsterdam}, issn = {1386-0291}, doi = {10.3233/CH-152027}, pages = {667 -- 680}, year = {2016}, abstract = {A high cell viability of around 99 +/- 18\% and 99 +/- 5\% was observed when THP-1 cells were cultured in the presence of aqueous extracts of the PEI microparticles in medium A and medium B respectively. The obtained microscopic data suggested that PEI particle extracts have no significant effect on cell death, oxidative stress or differentiation to macrophages. It was further found that the investigated proinflammatory markers in THP-1 cells were not up-regulated. These results are promising with regard to the biocompatibility of PEI microparticles and in a next step the hemocompatibility of the microparticles will be examined.}, language = {en} }