@article{RawelRantersRohnetal.2004,
  author    = {Rawel, Harshadrai Manilal and Ranters, Holger and Rohn, Sascha and Kroll, J{\"u}rgen},
  title     = {Assessment of the reactivity of selected isoflavones against proteins in comparison to quercetin},
  year      = {2004},
  abstract  = {Selected isoflavones (genistein, daidzein, formononetin, prunetin, biochanin A and two synthetic isoflavones) were allowed to interact with soy and whey proteins. The reaction products were analyzed in terms of covalent binding at the nucleophilic side chains of proteins. Changes in molecular properties of the proteins derivatives were documented by SDS-PAGE, IEF and SELDI-TOF-MS. The structural changes induced were studied using circular dichroism (CD). The in vitro digestibility was assessed with trypsin. The results show that the occurrence of the catechol moiety, i.e. the two adjacent (ortho) aromatic hydroxyl groups on ring B of the flavonoid structural skeleton appears to be perquisite condition for covalent binding to proteins. The catechol moiety on ring A was less reactive. Its absence lead to a slight or no significant reaction, although non-covalent interactions may still be possible even when lacking this structural element. A comparison of the data is also made with quercetin representing the flavonols.},
  language  = {en}
}
@article{KrollRantersRaweletal.2004,
  author    = {Kroll, J{\"u}rgen and Ranters, Holger and Rawel, Harshadrai Manilal and Rohn, Sascha},
  title     = {Isoflavones as constituents of plant foods : Isoflavone als Bestandteile pflanzlicher Lebensmittel},
  year      = {2004},
  abstract  = {Vor dem Hintergrund der Diskussion {\"u}ber die ern{\"a}hrungsphysiologische Bedeutung von Isoflavonen befasst sich die vorliegende {\"U}bersichtsarbeit auf der Basis von 186 Literaturquellen mit der Struktur, dem Vorkommen, der Aufnahme, der Biosynthese, der Resorption, dem Metabolismus und der biologischen Wirkung dieser Untergruppen der Pflanzenphenole. Diskutiert werden sowohl positive als auch negative biologische Wirkungen dieser Verbindungen. Strukturabh{\"a}ngig k{\"o}nnen die Isoflavone mit anderen Lebensmittelinhaltsstoffen in Wechselwirkung treten. With the background of the actual ongoing discussion on the nutritional},
  language  = {de}
}