@unpublished{HocherReichetzeder2013, author = {Hocher, Berthold and Reichetzeder, Christoph}, title = {Vitamin D and cardiovascular risk in postmenopausal women how to translate preclinical evidence into benefit for patients}, series = {Kidney international : official journal of the International Society of Nephrology}, volume = {84}, journal = {Kidney international : official journal of the International Society of Nephrology}, number = {1}, publisher = {Nature Publ. Group}, address = {New York}, issn = {0085-2538}, doi = {10.1038/ki.2013.139}, pages = {9 -- 11}, year = {2013}, abstract = {Preclinical work indicates that calcitriol restores vascular function by normalizing the endothelial expression of cyclooxygenase-2 and thromboxane-prostanoid receptors in conditions of estrogen deficiency and thus prevents the thromboxane-prostanoid receptor activation-induced inhibition of nitric oxide synthase. Since endothelial dysfunction is a key factor in the pathogenesis of cardiovascular diseases, this finding may have an important translational impact. It provides a clear rationale to use endothelial function in clinical trials aiming to find the optimal dose of vitamin D for the prevention of cardiovascular events in postmenopausal women.}, language = {en} }