@article{SchwarzeSperlichMuelleretal.2021, author = {Schwarze, Thomas and Sperlich, Eric and M{\"u}ller, Thomas and Kelling, Alexandra and Holdt, Hans-J{\"u}rgen}, title = {Synthesis efforts of acyclic bis(monoalkylamino)maleonitriles and macrocyclic bis(dialkylamino)maleonitriles as fluorescent probes for cations and a new colorimetric copper(II) chemodosimeter}, series = {Helvetica chimica acta}, volume = {104}, journal = {Helvetica chimica acta}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1522-2675}, doi = {10.1002/hlca.202100028}, pages = {e2100028}, year = {2021}, abstract = {In this article, we report on the synthesis of acyclic bis(monoalkylamino)maleonitriles and on the intended synthesis of macrocyclic bis(dialkylamino)maleonitriles to get fluorescent probes for cations. During our efforts to synthesize macrocyclic bis(dialkylamino)maleonitriles, we were only able to isolate macrocyclic bis(dialkylamino)-fumaronitriles. The synthesis of macrocyclic bis(dialkylamino)maleonitriles is challenging, due to the fact that bis-(dialkylamino)fumaronitriles are thermodynamically more stable than the corresponding bis(dialkylamino)-maleonitriles. Further, it turned out that the acyclic bis(monoalkylamino)maleonitriles and macrocyclic bis-(dialkylamino)fumaronitriles are no suitable tools to detect cations by a strong fluorescence enhancement. Further, only the bis(monoalkylamino)maleonitriles, which are bearing a 2-pyridyl unit as an additional complexing unit, are able to selectively recognize copper(II) by a color change from yellow to red.}, language = {en} } @misc{MaierWolfKeiligetal.2018, author = {Maier, Philipp and Wolf, J{\"u}rgen and Keilig, Thomas and Krabbe, Alfred and Duffard, Rene and Ortiz, Jose-Luis and Klinkner, Sabine and Lengowski, Michael and M{\"u}ller, Thomas and Lockowandt, Christian and Krockstedt, Christian and Kappelmann, Norbert and Stelzer, Beate and Werner, Klaus and Geier, Stephan Alfred and Kalkuhl, Christoph and Rauch, Thomas and Schanz, Thomas and Barnstedt, J{\"u}rgen and Conti, Lauro and Hanke, Lars}, title = {Towards a European Stratospheric Balloon Observatory}, series = {Ground-based and Airborne Telescopes VII}, volume = {10700}, journal = {Ground-based and Airborne Telescopes VII}, publisher = {SPIE-INT Soc Optical Engineering}, address = {Bellingham}, isbn = {978-1-5106-1954-8}, issn = {0277-786X}, doi = {10.1117/12.2319248}, pages = {12}, year = {2018}, abstract = {This paper presents the concept of a community-accessible stratospheric balloon-based observatory that is currently under preparation by a consortium of European research institutes and industry. We present the technical motivation, science case, instrumentation, and a two-stage image stabilization approach of the 0.5-m UV/visible platform. In addition, we briefly describe the novel mid-sized stabilized balloon gondola under design to carry telescopes in the 0.5 to 0.6 m range as well as the currently considered flight option for this platform. Secondly, we outline the scientific and technical motivation for a large balloon-based FIR telescope and the ESBO DS approach towards such an infrastructure.}, language = {en} } @article{SchatzFreulingAueretal.2014, author = {Schatz, Juliane and Freuling, Conrad Martin and Auer, Ernst and Goharriz, Hooman and Harbusch, Christine and Johnson, Nicholas and Kaipf, Ingrid and Mettenleiter, Thomas Christoph and Muehldorder, Kristin and Muehle, Ralf-Udo and Ohlendorf, Bernd and Pott-D{\"o}rfer, B{\"a}rbel and Prueger, Julia and Ali, Hanan Sheikh and Stiefel, Dagmar and Teubner, Jens and Ulrich, Rainer G{\"u}nter and Wibbelt, Gudrun and M{\"u}ller, Thomas}, title = {Enhanced passive bat rabies surveillance in indigenous bat species from Germany - A retrospective study}, series = {PLoS neglected tropical diseases}, volume = {8}, journal = {PLoS neglected tropical diseases}, number = {5}, publisher = {PLoS}, address = {San Fransisco}, issn = {1935-2735}, doi = {10.1371/journal.pntd.0002835}, pages = {9}, year = {2014}, abstract = {In Germany, rabies in bats is a notifiable zoonotic disease, which is caused by European bat lyssaviruses type 1 and 2 (EBLV-1 and 2), and the recently discovered new lyssavirus species Bokeloh bat lyssavirus (BBLV). As the understanding of bat rabies in insectivorous bat species is limited, in addition to routine bat rabies diagnosis, an enhanced passive surveillance study, i.e. the retrospective investigation of dead bats that had not been tested for rabies, was initiated in 1998 to study the distribution, abundance and epidemiology of lyssavirus infections in bats from Germany. A total number of 5478 individuals representing 21 bat species within two families were included in this study. The Noctule bat (Nyctalus noctula) and the Common pipistrelle (Pipistrellus pipistrellus) represented the most specimens submitted. Of all investigated bats, 1.17\% tested positive for lyssaviruses using the fluorescent antibody test (FAT). The vast majority of positive cases was identified as EBLV-1, predominately associated with the Serotine bat (Eptesicus serotinus). However, rabies cases in other species, i.e. Nathusius' pipistrelle bat (Pipistrellus nathusii), P. pipistrellus and Brown long-eared bat (Plecotus auritus) were also characterized as EBLV-1. In contrast, EBLV-2 was isolated from three Daubenton's bats (Myotis daubentonii). These three cases contribute significantly to the understanding of EBLV-2 infections in Germany as only one case had been reported prior to this study. This enhanced passive surveillance indicated that besides known reservoir species, further bat species are affected by lyssavirus infections. Given the increasing diversity of lyssaviruses and bats as reservoir host species worldwide, lyssavirus positive specimens, i.e. both bat and virus need to be confirmed by molecular techniques.}, language = {en} } @article{JeltschBontePeeretal.2013, author = {Jeltsch, Florian and Bonte, Dries and Peer, Guy and Reineking, Bj{\"o}rn and Leimgruber, Peter and Balkenhol, Niko and Schr{\"o}der-Esselbach, Boris and Buchmann, Carsten M. and M{\"u}ller, Thomas and Blaum, Niels and Zurell, Damaris and B{\"o}hning-Gaese, Katrin and Wiegand, Thorsten and Eccard, Jana and Hofer, Heribert and Reeg, Jette and Eggers, Ute and Bauer, Silke}, title = {Integrating movement ecology with biodiversity research - exploring new avenues to address spatiotemporal biodiversity dynamics}, doi = {10.1186/2051-3933-1-6}, year = {2013}, language = {en} } @article{KruckenbergMuellerFreulingetal.2011, author = {Kruckenberg, Helmut and M{\"u}ller, Thomas and Freuling, Conrad and M{\"u}hle, Ralf-Udo and Globig, Anja and Schirrmeier, Horst and Buss, Melanie and Harder, Timm and Kramer, Matthias and Teske, Kathrin and Polderdijk, Kees and Wallschl{\"a}ger, Hans-Dieter and Hlinak, Andreas}, title = {Serological and virological survey and resighting of marked wild geese in Germany}, series = {European journal of wildlife research}, volume = {57}, journal = {European journal of wildlife research}, number = {5}, publisher = {Springer}, address = {New York}, issn = {1612-4642}, doi = {10.1007/s10344-011-0514-1}, pages = {1025 -- 1032}, year = {2011}, abstract = {In order to investigate the potential role of arctic geese in the epidemiology, the spatial and temporal spread of selected avian diseases, in autumn 2002, a virological and serological survey designed as capture-mark-resighting study was conducted in one of the most important coastal resting sites for migratory waterfowl in Germany. Orophatyngeal, cloacal swabs and blood samples were collected from a total of 147 birds comprising of three different arctic geese species including White-fronted Goose (Anser albifrons), Tundra Bean Goose (Anser fabalis rossicus), Pink-footed Goose (Anser brachyrhynchus) as well as from 29 non-migratory Canada Geese (Branta canadensis). Altogether, six adeno-like viruses (ALV; 95\% CI, 1.74-9.92\%) and two avian paramyxoviruses (APMV-4; 95\% Cl, 0.19-5.53\%) were isolated mainly from juvenile White-fronted Geese. In addition, four Canada Geese were infected with lentogenic APMV-1 (95\% CI, 3.89-31.66\%) at the date of sampling. No avian influenza viruses, reo-like viruses could be isolated despite serological evidence. Likewise, no evidence of current or previous infection by West Nile virus was found. Of the 147 birds tagged in the following years, 137 birds were resighted between 2002 and 2008 accumulating to 1925 sightings. About 90\% of all sightings were reported from the main wintering and resting sites in Germany and The Netherlands. Eight of the resighted geese were virus positive (ALV and APMV-4) at the time point of sampling in 2002.}, language = {en} } @article{HlinakMuehleWerneretal.2006, author = {Hlinak, Andreas and M{\"u}hle, Ralf-Udo and Werner, Ortrud and Globig, Anja and Starick, Elke and Schirrmeier, Horst and Hoffmann, Bernd and Engelhardt, Andreas and H{\"u}bner, Dagmar and Conraths, Franz J. and Wallschl{\"a}ger, Hans-Dieter and Kruckenberg, Helmut and M{\"u}ller, Thomas}, title = {A virological survey in migrating waders and other waterfowl in one of the most important resting sites of Germany}, issn = {0931-1793}, year = {2006}, abstract = {Wild birds are considered a potential reservoir or a carrier of viral diseases and may therefore play a role in the epidemiology of economically important or zoonotic diseases. In 2001 and 2002, a survey with special emphasis oil virus isolation in migrating waders and some other birds were conducted. In one of the most important inland resting sites for migratory waterfowl, tracheal and cloacal swabs were collected from 465 waders representing 19 different species, and 165 other birds that were not captured on purpose. A total of 42 avian viruses were isolated, 34 of these were identified as paramyxoviruses (PMVs). The majority of isolates came from waders and wild ducks, and were characterized as PMV-1. In contrast, PMV-4 was found in wild ducks only, PMV-6 was mainly detected in wader species. Four avian influenza viruses (ATVs), belonging to H4 and H3 haemagglutinin subtype, were isolated from wild duck species. Furthermore, four reo-like viruses were isolated from one particular wader species for the first time. The majority of virus positive birds were < 1 year old and did not show any clinical symptoms. There was no evidence for the presence of West Nile virus in these birds. These results confirm that the restricted resting sites in Western Europe must be considered as important locations for the intra- and interspecies transmission of avian viruses}, language = {en} } @article{HoldtMuellerKellingetal.2006, author = {Holdt, Hans-J{\"u}rgen and M{\"u}ller, Holger and Kelling, Alexandra and Drexler, Hans-Joachim and M{\"u}ller, Thomas and Schwarze, Thomas and Schilde, Uwe and Starke, Ines}, title = {Mercury(II) chloride and iodide complexes of dithia- and tetrathiacrown ethers}, issn = {0044-2313}, doi = {10.1002/zaac.200500281}, year = {2006}, abstract = {The complexes [(HgCl2)(2)((ch)(2)30S(4)O(6))] (1), [HgCl,(mn21S(2)O(5))] (2), [HgCl2(ch18S(2)O(4))] (3) and [HgI(meb12S(2)O(2))](2)[Hg2I6] (4) have been synthesized, characterized and their crystal structures were determined. In [(HgCl2)(2)((ch)(2)3OS(4)O(6))] two HgCl2 units are discretely bonded within the ligand cavity of the 30-membered dichinoxaline-tetrathia-30-crown-10 ((ch)(2)30S(4)O(6)) forming a binuclear complex. HgCl2 forms I : I "in-cavity" complexes with the 21-membered maleonitrile-dithia-21-crown-7(mn21S(2)O(5)) ligand and the 18-membered chinoxaline- dithia-18-crown-6 (ch18S(2)O(4)) ligand, respectively. The 12-membered 4-methyl-benzo-dithia-12-crown-4 (meb12S(2)O(2)) ligand gave with two equivalents HgI2 the compound [HgI(meb12S(2)O(2))](2)[Hg2I6]. In the cation [HgI(meb12S(2)O(2))](+) meb12S(2)O(2) forms with the cation HgI+ a half-sandwich complex}, language = {en} } @article{HlinakMuellerKrameretal.1999, author = {Hlinak, Andreas and M{\"u}ller, Thomas and Kramer, Matthias and M{\"u}hle, Ralf-Udo and Liebherr, Helga and Ziedler, Klaus}, title = {A descriptive analysis of the potenrial association between migration patterns of bean and white-fronted geese and the occurence of newcastle disease outbreaks in domestic birds}, issn = {0005-2086}, year = {1999}, abstract = {Sightings and migration patterns of 65 bean and 65 white-fronted geese are reported. These geese were tagged and serologically screened. 19 of the 53 birds sighted had serologic evidence of Newcastle Disease. The migration patterns of the wild geese provided further evidence that the main resting and wintering sites of migratory waterfowl are likely to be important for the inter- and intraspecies transmission of avian diseases.}, language = {en} } @article{HlinakMuellerKrameretal.1998, author = {Hlinak, Andreas and M{\"u}ller, Thomas and Kramer, Matthias and M{\"u}hle, Ralf-Udo and Liebherr, Helga and Ziedler, Klaus}, title = {Serological survey of viral pathogens in bean and white-fronted geese from Germany}, issn = {0090-3558}, year = {1998}, language = {en} }