@article{SarrarHolzhausenWarschburgeretal.2016, author = {Sarrar, Lea and Holzhausen, Martin and Warschburger, Petra and Pfeiffer, Ernst and Lehmkuhl, Ulrike and Schneider, Nora}, title = {Cognitive Function in Adolescent Patients with Anorexia Nervosa and Unipolar Affective Disorders}, series = {European eating disorders review : the professional journal of the Eating Disorders Associatio}, volume = {24}, journal = {European eating disorders review : the professional journal of the Eating Disorders Associatio}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1072-4133}, doi = {10.1002/erv.2425}, pages = {232 -- 240}, year = {2016}, abstract = {Studies have shown impairments in cognitive function among adult patients with anorexia nervosa (AN) and affective disorders (AD). The association between cognitive dysfunctions, AN and AD as well as the specificity for these psychiatric diagnoses remains unclear. Therefore, we examined cognitive flexibility and processing speed in 47 female adolescent patients with AN, 21 female adolescent patients with unipolar affective disorders and 48 female healthy adolescents. All participants completed a neuropsychological test battery. There were no significant group differences regarding cognitive function, except for psychomotor processing speed with poorer performance in patients with AN. A further analysis revealed that all groups performed with the normal range, although patients with AN were over represented in the poorest performing quartile. We found no severe cognitive impairments in either patient group. Nevertheless, belonging to the AN group contributed significantly to poor performances in neuropsychological tasks. Therefore, we conclude that the risk for cognitive impairments is slightly higher for patients with AN. Copyright (c) 2015 John Wiley \& Sons, Ltd and Eating Disorders Association.}, language = {en} } @article{KochTitzeZimmeretal.2004, author = {Koch, Sabine and Titze, Karl and Zimmer, Ulrike and Lehmkuhl, Ulrike and Rauh, Hellgard and Helge, Hans}, title = {Growth of children exposed to antiepileptic medications in the womb}, issn = {0026-9298}, year = {2004}, abstract = {Antiepileptic drugs are suspected of being weakly teratogenic in humans. In a prospective longitudinal study, we assessed growth parameters of children from birth to adolescence who had been prenatally exposed to various antiepileptic drugs and compared them to non-exposed control children matched for parental body length, social status, and maternal nicotine consumption during pregnancy as well as for parity. While no differences in mean head circumferences could be ascertained in the group of exposed children at 1, 6, and 14 years, differences were measured in body length at I year. The differences were more pronounced for both measurements when therapy forms and types of drugs were considered: polytherapy and phenobarbitone therapy (which was usually part of polytherapy) of the mother appeared to have an influence on the children's growth. Children exposed to polytherapy and phenobarbitone (as single drug or as part of polytherapy) had smaller head circumferences and were shorter. We assume an influence of polytherapy and phenobarbitone therapy taken by the epileptic woman during pregnancy on the growth of the child into adolescence}, language = {en} } @article{KochTitzeTreuteretal.2000, author = {Koch, Sabine and Titze, Karl and Treuter, S. and Schr{\"o}der, M. and Zimmermann, Ralf B. and Steinhausen, Hans-Christoph and Lehmkuhl, Ulrike and Rauh, Hellgard}, title = {Maternal use of valproate during pregnancy, risk of major malformations, and brain disorder}, year = {2000}, language = {en} } @article{TitzeKochHelgeetal.2008, author = {Titze, Karl and Koch, Sabine and Helge, Hans and Lehmkuhl, Ulrike and Rauh, Hellgard and Steinhausen, Hans-Christoph}, title = {Prenatal and familial risks of children born by epileptic mothers : long term effects on the cognitive development}, doi = {10.1111/j.1469-8749.2007.02020.x}, year = {2008}, language = {en} }