@misc{HischeLarhlimiSchwarzetal.2012,
  author    = {Hische, Manuela and Larhlimi, Abdelhalim and Schwarz, Franziska and Fischer-Rosinsk{\´y}, Antje and Bobbert, Thomas and Assmann, Anke and Catchpole, Gareth S. and Pfeiffer, Andreas F. H. and Willmitzer, Lothar and Selbig, Joachim and Spranger, Joachim},
  title     = {A distinct metabolic signature predictsdevelopment of fasting plasma glucose},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {850},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42740},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-427400},
  pages     = {12},
  year      = {2012},
  abstract  = {Background High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of impaired glucose metabolism and type 2 diabetes. However, the molecular basis of impaired glucose metabolism is so far insufficiently understood. The development of so called 'omics' approaches in the recent years promises to identify molecular markers and to further understand the molecular basis of impaired glucose metabolism and type 2 diabetes. Although univariate statistical approaches are often applied, we demonstrate here that the application of multivariate statistical approaches is highly recommended to fully capture the complexity of data gained using high-throughput methods. Methods We took blood plasma samples from 172 subjects who participated in the prospective Metabolic Syndrome Berlin Potsdam follow-up study (MESY-BEPO Follow-up). We analysed these samples using Gas Chromatography coupled with Mass Spectrometry (GC-MS), and measured 286 metabolites. Furthermore, fasting glucose levels were measured using standard methods at baseline, and after an average of six years. We did correlation analysis and built linear regression models as well as Random Forest regression models to identify metabolites that predict the development of fasting glucose in our cohort. Results We found a metabolic pattern consisting of nine metabolites that predicted fasting glucose development with an accuracy of 0.47 in tenfold cross-validation using Random Forest regression. We also showed that adding established risk markers did not improve the model accuracy. However, external validation is eventually desirable. Although not all metabolites belonging to the final pattern are identified yet, the pattern directs attention to amino acid metabolism, energy metabolism and redox homeostasis. Conclusions We demonstrate that metabolites identified using a high-throughput method (GC-MS) perform well in predicting the development of fasting plasma glucose over several years. Notably, not single, but a complex pattern of metabolites propels the prediction and therefore reflects the complexity of the underlying molecular mechanisms. This result could only be captured by application of multivariate statistical approaches. Therefore, we highly recommend the usage of statistical methods that seize the complexity of the information given by high-throughput methods.},
  language  = {en}
}
@misc{Kellner2012,
  author    = {Kellner, Michael},
  title     = {Agenda gegen Waffenhandel},
  issn      = {0944-8101},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-60480},
  year      = {2012},
  abstract  = {Deutschlands linke Mehrheit ist gespalten. In besonderem Maße betrifft dies außenpolitische Themen. Gegen den menschenfeindlichen Irrsinn von R{\"u}stungsexporten anzugehen k{\"o}nnte hingegen ein einigendes Projekt werden. Die Kanzlerin hat mit ihrer zynischen Behauptung, R{\"u}stungsexporte k{\"o}nnten Bestandteil von Konfliktbearbeitung sein, eine Steilvorlage geboten.},
  language  = {de}
}
@misc{Lenhard2012,
  author    = {Lenhard, Michael},
  title     = {All's well that ends well},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {906},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43803},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438035},
  pages     = {9 -- 11},
  year      = {2012},
  abstract  = {The transition from cell proliferation to cell expansion is critical for determining leaf size. Andriankaja et al. (2012) demonstrate that in leaves of dicotyledonous plants, a basal proliferation zone is maintained for several days before abruptly disappearing, and that chloroplast differentiation is required to trigger the onset of cell expansion.},
  language  = {en}
}
@misc{OPUS4-5704,
  title     = {Arabische Br{\"u}che},
  issn      = {0944-8101},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-58930},
  year      = {2012},
  abstract  = {K{\"o}nnen Araber Demokratie? Im Jahr II des Arabischen Fr{\"u}hlings werden erste zarte Triebe der Hoffnungen, die in diese Richtung neigten, von Soldatenstiefeln und fl{\"u}chtenden Demonstranten zertreten. Die versiegelte Zeit brach auf, doch was ist erreicht worden? In der neuen Ausgabe ziehen wir eine Bilanz, die ebenso sachlich wie zwiesp{\"a}ltig ist. Sie zeigt Erfolge, ohne zu besch{\"o}nigen. Probleme werden sichtbar gemacht, aber auch Wege zu ihrer L{\"o}sung. Auch Europa ist gefragt: Wir m{\"u}ssen zu einem neuen, partnerschaftlichen Verh{\"a}ltnis mit den sich wandelnden arabischen Nationen finden!},
  language  = {de}
}
@misc{OstrowskiSchaub2012,
  author    = {Ostrowski, Max and Schaub, Torsten H.},
  title     = {ASP modulo CSP},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {579},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41390},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413908},
  pages     = {19},
  year      = {2012},
  abstract  = {We present the hybrid ASP solver clingcon, combining the simple modeling language and the high performance Boolean solving capacities of Answer Set Programming (ASP) with techniques for using non-Boolean constraints from the area of Constraint Programming (CP). The new clingcon system features an extended syntax supporting global constraints and optimize statements for constraint variables. The major technical innovation improves the interaction between ASP and CP solver through elaborated learning techniques based on irreducible inconsistent sets. A broad empirical evaluation shows that these techniques yield a performance improvement of an order of magnitude.},
  language  = {en}
}
@misc{Gatzhammer2012,
  author    = {Gatzhammer, Stefan},
  title     = {Aspekte des religi{\"o}s motivierten Tourismus in Europa heute},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62026},
  pages     = {253 -- 271},
  year      = {2012},
  abstract  = {Wallfahrten und Pilgerreisen, allgemein der religi{\"o}s motivierte Tourismus erfreut sich in Europa heute aus unterschiedlichen Motiven wachsender Zustimmung. Die Motivation hierzu wurzelt letztendlich im Bereich der religi{\"o}sen Emotionalit{\"a}t. Untersucht wird diese Form spiritueller Orientierung in der religi{\"o}sen Gegenwartskultur auch in seiner Auswirkung auf die religi{\"o}sen Institutionen. Die M{\"o}glichkeit zu religi{\"o}s motiviertem Reisen kommt dem Bed{\"u}rfnis nach mehr Religiosit{\"a}t entgegen, ohne daß der Pilgertourist gezwungen ist, sich l{\"a}ngerfristig an kirchliche Strukturen binden zu m{\"u}ssen. Der christliche Religionstourismus ist ein bedeutender Globalisierungsfaktor und zahlenm{\"a}ßig die gr{\"o}ßte Mobilisierung von Religion.},
  language  = {de}
}
@misc{OPUS4-5849,
  title     = {Brasilien - Land der Gegens{\"a}tze},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-60493},
  year      = {2012},
  abstract  = {F{\"u}r Stefan Zweig war Brasilien 1941 "ein Land der Zukunft". Die Realit{\"a}t sieht anders aus: Bis heute ist es ein Land der Gegens{\"a}tze, gepr{\"a}gt vor allem durch jenen von Arm und Reich. Was Gini-Koeffizienten n{\"u}chtern in Zahlen ausdr{\"u}cken, kann man in Metropolen mit hypermodernen Zentren und Favelas an Bergh{\"a}ngen auf engstem Raum erleben. Vor allem die Verteilung von Land resultiert in Auseinandersetzungen. Experten analysieren im Thema die Lage eines Staates, der in seinen Widerspr{\"u}chlichkeiten gefangen ist.},
  language  = {de}
}
@misc{OskinovaFeldmeierKretschmar2012,
  author    = {Oskinova, Lida and Feldmeier, Achim and Kretschmar, Peter},
  title     = {Clumped stellar winds in supergiant high-mass X-ray binaries},
  series = {Postprint der universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprint der universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {573},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41391},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413916},
  pages     = {287 -- 288},
  year      = {2012},
  abstract  = {The clumping of massive star winds is an established paradigm, which is confirmed by multiple lines of evidence and is supported by stellar wind theory. We use the results from time-dependent hydrodynamical models of the instability in the line-driven wind of a massive supergiant star to derive the time-dependent accretion rate on to a compact object in the Bondi-Hoyle-Lyttleton approximation. The strong density and velocity fluctuations in the wind result in strong variability of the synthetic X-ray light curves. Photoionization of inhomogeneous winds is different from the photoinization of smooth winds. The degree of ionization is affected by the wind clumping. The wind clumping must also be taken into account when comparing the observed and model spectra of the photoionized stellar wind.},
  language  = {en}
}
@misc{PowellLenhard2012,
  author    = {Powell, Anahid E. and Lenhard, Michael},
  title     = {Control of organ size in plants},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {898},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43802},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-438029},
  pages     = {10},
  year      = {2012},
  abstract  = {The size of plant organs, such as leaves and flowers, is determined by an interaction of genotype and environmental influences. Organ growth occurs through the two successive processes of cell proliferation followed by cell expansion. A number of genes influencing either or both of these processes and thus contributing to the control of final organ size have been identified in the last decade. Although the overall picture of the genetic regulation of organ size remains fragmentary, two transcription factor/microRNA-based genetic pathways are emerging in the control of cell proliferation. However, despite this progress, fundamental questions remain unanswered, such as the problem of how the size of a growing organ could be monitored to determine the appropriate time for terminating growth. While genetic analysis will undoubtedly continue to advance our knowledge about size control in plants, a deeper understanding of this and other basic questions will require including advanced live-imaging and mathematical modeling, as impressively demonstrated by some recent examples. This should ultimately allow the comparison of the mechanisms underlying size control in plants and in animals to extract common principles and lineage-specific solutions.},
  language  = {en}
}
@misc{AbujatumBerndt2012,
  author    = {Abujatum Berndt, Leonor},
  title     = {Daf{\"u}r sollten wir uns nicht verschulden m{\"u}ssen! : Bildungsrevolution in Chile},
  issn      = {0944-8101},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57946},
  year      = {2012},
  abstract  = {Weltweit brodelt es, B{\"u}rger gehen auf die Straße. In Chile will man sich die Ungerechtigkeiten des Bildungssystems nicht l{\"a}nger gefallen lassen. Nur wer zahlt, darf lernen - dagegen wehrt sich vor allem die Jugend mit aller Macht, auch mit der Macht der Neuen Medien. {\"O}ffentlichkeitswirksam werden die Proteste inszeniert. Wird die chilenische Regierung weiterhin mit Kn{\"u}ppeln auf Demonstranten einschlagen oder einlenken?},
  language  = {de}
}