@article{TejosRodriguezFurlanAdamowskietal.2018, author = {Tejos, Ricardo and Rodriguez-Furlan, Cecilia and Adamowski, Maciej and Sauer, Michael and Norambuena, Lorena and Friml, Jiri}, title = {PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana}, series = {Journal of cell science}, volume = {131}, journal = {Journal of cell science}, number = {2}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {0021-9533}, doi = {10.1242/jcs.204198}, pages = {10}, year = {2018}, abstract = {Coordinated cell polarization in developing tissues is a recurrent theme in multicellular organisms. In plants, a directional distribution of the plant hormone auxin is at the core of many developmental programs. A feedback regulation of auxin on the polarized localization of PIN auxin transporters in individual cells has been proposed as a self-organizing mechanism for coordinated tissue polarization, but the molecular mechanisms linking auxin signalling to PIN-dependent auxin transport remain unknown. We used a microarray-based approach to find regulators of the auxin-induced PIN relocation in Arabidopsis thaliana root, and identified a subset of a family of phosphatidylinositol transfer proteins (PITPs), the PATELLINs (PATLs). Here, we show that PATLs are expressed in partially overlapping cell types in different tissues going through mitosis or initiating differentiation programs. PATLs are plasma membrane-associated proteins accumulated in Arabidopsis embryos, primary roots, lateral root primordia and developing stomata. Higher order patl mutants display reduced PIN1 repolarization in response to auxin, shorter root apical meristem, and drastic defects in embryo and seedling development. This suggests that PATLs play a redundant and crucial role in polarity and patterning in Arabidopsis.}, language = {en} } @article{BollierSicardLeblondetal.2018, author = {Bollier, Norbert and Sicard, Adrien and Leblond, Julie and Latrasse, David and Gonzalez, Nathalie and Gevaudant, Frederic and Benhamed, Moussa and Raynaud, Cecile and Lenhard, Michael and Chevalier, Christian and Hernould, Michel and Delmas, Frederic}, title = {At-MINI ZINC FINGER2 and Sl-INHIBITOR OF MERISTEM ACTIVITY, a Conserved Missing Link in the Regulation of Floral Meristem Termination in Arabidopsis and Tomato}, series = {The plant cell}, volume = {30}, journal = {The plant cell}, number = {1}, publisher = {American Society of Plant Physiologists}, address = {Rockville}, issn = {1040-4651}, doi = {10.1105/tpc.17.00653}, pages = {83 -- 100}, year = {2018}, abstract = {In angiosperms, the gynoecium is the last structure to develop within the flower due to the determinate fate of floral meristem (FM) stem cells. The maintenance of stem cell activity before its arrest at the stage called FM termination affects the number of carpels that develop. The necessary inhibition at this stage of WUSCHEL (WUS), which is responsible for stem cell maintenance, involves a two-step mechanism. Direct repression mediated by the MADS domain transcription factor AGAMOUS (AG), followed by indirect repression requiring the C2H2 zinc-finger protein KNUCKLES (KNU), allow for the complete termination of floral stem cell activity. Here, we show that Arabidopsis thaliana MINI ZINC FINGER2 (AtMIF2) and its homolog in tomato (Solanum lycopersicum), INHIBITOR OF MERISTEM ACTIVITY (SlIMA), participate in the FM termination process by functioning as adaptor proteins. AtMIF2 and SlIMA recruit AtKNU and SlKNU, respectively, to form a transcriptional repressor complex together with TOPLESS and HISTONE DEACETYLASE19. AtMIF2 and SlIMA bind to the WUS and SIWUS loci in the respective plants, leading to their repression. These results provide important insights into the molecular mechanisms governing (FM) termination and highlight the essential role of AtMIF2/SlIMA during this developmental step, which determines carpel number and therefore fruit size.}, language = {en} } @article{GeigerKocyan2018, author = {Geiger, Daniel L. and Kocyan, Alexander}, title = {Studies on Oberonia 3. Aberrant flowers and other floral modifications in the orchid genus Oberonia}, series = {Nordic Journal of botany}, volume = {36}, journal = {Nordic Journal of botany}, number = {1-2}, publisher = {Wiley}, address = {Hoboken}, issn = {0107-055X}, doi = {10.1111/njb.01699}, pages = {8}, year = {2018}, abstract = {Orchid flowers are amongst the most conspicuous attractions that plants have generated over evolutionary epochs. However, organ homology in particular of androecium and gynoecium of orchid flowers have been, and are still, the subject of long-term discussion. Studies of aberrant - teratologic - flowers have traditionally helped to clarify organ identity in orchids. We here present for the first time teratological flowers within the florally smallest and inconspicuous orchid genus Oberonia and illustrate them by light and scanning electron microscopy. Pseudopeloria with half of a lateral petal transformed into a lip was found in O. costeriana J.J.Sm. and O. mucronata (D.Don) Ormerod \& Seidenf. A supernumerary lip is known from O. mucronata. Oberonia rufilabris Lindl. is documented with multiple aberrations: triple gynostemium and a total of 10 tepals, twin flowers, and duplicate lips. We interpret these aberrations in light of known floral developmental and organ identity information.}, language = {en} } @article{KimShprits2018, author = {Kim, Kyung-Chan and Shprits, Yuri Y.}, title = {Survey of the Favorable Conditions for Magnetosonic Wave Excitation}, series = {Journal of geophysical research : Space physics}, volume = {123}, journal = {Journal of geophysical research : Space physics}, number = {1}, publisher = {American Geophysical Union}, address = {Washington}, issn = {2169-9380}, doi = {10.1002/2017JA024865}, pages = {400 -- 413}, year = {2018}, abstract = {The ratio of the proton ring velocity (VR) to the local Alfven speed (VA), in addition to proton ring distributions, plays a key factor in the excitation of magnetosonic waves at frequencies between the proton cyclotron frequency fcp and the lower hybrid resonance frequency fLHR in the Earth's magnetosphere. Here we investigate whether there is a statistically significant relationship between occurrences of proton rings and magnetosonic waves both outside and inside the plasmapause using particle and wave data from Van Allen Probe-A during the time period of October 2012 to December 2015. We also perform a statistical survey of the ratio of the ring energy (ER, corresponding to VR) to the Alfven energy (EA, corresponding to VA) to determine the favorable conditions under which magnetosonic waves in each of two frequency bands (fcp < f ≤ 0.5 fLHR and 0.5 fLHR < f < fLHR) can be excited. The results show that the magnetosonic waves in both frequency bands occur around the postnoon (12-18 magnetic local time, MLT) sector outside the plasmapause when ER is comparable to or lower than EA, and those in lower-frequency bands (fcp < f ≤ 0.5 fLHR) occur around the postnoon sector inside the plasmapause when ER/EA > ~9. However, there is one discrepancy between occurrences of proton rings and magnetosonic waves in low-frequency bands around the prenoon sector (6-12 MLT) outside the plasmapause, which suggests either that the waves may have propagated during active time from the postnoon sector after being excited during quiet time, or they may have locally excited in the prenoon sector during active time.}, language = {en} } @article{LuReichetzederPrehnetal.2018, author = {Lu, Yong-Ping and Reichetzeder, Christoph and Prehn, Cornelia and von Websky, Karoline and Slowinski, Torsten and Chen, You-Peng and Yin, Liang-Hong and Kleuser, Burkhard and Yang, Xue-Song and Adamski, Jerzy and Hocher, Berthold}, title = {Fetal serum metabolites are independently associated with Gestational diabetes mellitus}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {45}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000487119}, pages = {625 -- 638}, year = {2018}, abstract = {Background/Aims: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. Methods: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. Results: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholine acyl-alkyl C 32:1 and proline still showed an independent association with GDM. Conclusions: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal serum metabolites and maternal GDM. Our findings might suggest a potential effect of the fetal metabolome on maternal GDM. (c) 2018 The Author(s) Published by S. Karger AG, Basel}, language = {en} } @article{LuReichetzederPrehnetal.2018, author = {Lu, Yong-Ping and Reichetzeder, Christoph and Prehn, Cornelia and Yin, Liang-Hong and Yun, Chen and Zeng, Shufei and Chu, Chang and Adamski, Jerzy and Hocher, Berthold}, title = {Cord blood Lysophosphatidylcholine 16:1 is positively associated with birth weight}, series = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, volume = {45}, journal = {Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {1015-8987}, doi = {10.1159/000487118}, pages = {614 -- 624}, year = {2018}, abstract = {Background/Aims: Impaired birth outcomes, like low birth weight, have consistently been associated with increased disease susceptibility to hypertension in later life. Alterations in the maternal or fetal metabolism might impact on fetal growth and influence birth outcomes. Discerning associations between the maternal and fetal metabolome and surrogate parameters of fetal growth could give new insight into the complex relationship between intrauterine conditions, birth outcomes, and later life disease susceptibility. Methods: Using flow injection tandem mass spectrometry, targeted metabolomics was performed in serum samples obtained from 226 mother/child pairs at delivery. Associations between neonatal birth weight and concentrations of 163 maternal and fetal metabolites were analyzed. Results: After FDR adjustment using the Benjamini-Hochberg procedure lysophosphatidylcholines (LPC) 14:0, 16:1, and 18:1 were strongly positively correlated with birth weight. In a stepwise linear regression model corrected for established confounding factors of birth weight, LPC 16: 1 showed the strongest independent association with birth weight (CI: 93.63 - 168.94; P = 6.94x10(-11)). The association with birth weight was stronger than classical confounding factors such as offspring sex (CI: - 258.81- -61.32; P = 0.002) and maternal smoking during pregnancy (CI: -298.74 - -29.51; P = 0.017). Conclusions: After correction for multiple testing and adjustment for potential confounders, LPC 16:1 showed a very strong and independent association with birth weight. The underlying molecular mechanisms linking fetal LPCs with birth weight need to be addressed in future studies. (c) 2018 The Author(s) Published by S. Karger AG, Basel}, language = {en} } @article{SmithBookhagen2018, author = {Smith, Taylor and Bookhagen, Bodo}, title = {Changes in seasonal snow water equivalent distribution in High Mountain Asia (1987 to 2009)}, series = {Science Advances}, volume = {4}, journal = {Science Advances}, number = {1}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {2375-2548}, doi = {10.1126/sciadv.1701550}, pages = {8}, year = {2018}, abstract = {Snow meltwaters account for most of the yearly water budgets of many catchments in High Mountain Asia (HMA). We examine trends in snow water equivalent (SWE) using passive microwave data (1987 to 2009). We find an overall decrease in SWE in HMA, despite regions of increased SWE in the Pamir, Kunlun Shan, Eastern Himalaya, and Eastern Tien Shan. Although the average decline in annual SWE across HMA (contributing area, 2641 x 10(3) km(2)) is low (average, -0.3\%), annual SWE losses conceal distinct seasonal and spatial heterogeneities across the study region. For example, the Tien Shan has seen both strong increases in winter SWE and sharp declines in spring and summer SWE. In the majority of catchments, the most negative SWE trends are found in mid-elevation zones, which often correspond to the regions of highest snow-water storage and are somewhat distinct from glaciated areas. Negative changes in SWE storage in these mid-elevation zones have strong implications for downstream water availability.}, language = {en} } @article{HuschekBoenickMerkeletal.2018, author = {Huschek, Gerd and B{\"o}nick, Josephine and Merkel, Dietrich and Huschek, Doreen and Rawel, Harshadrai Manilal}, title = {Authentication of leguminous-based products by targeted biomarkers using high resolution time of flight mass spectrometry}, series = {LWT - food science and technology : an official journal of the Swiss Society of Food Science and Technology (SGLWT/SOSSTA) and the International Union of Food Science and Technology (IUFoST)}, volume = {90}, journal = {LWT - food science and technology : an official journal of the Swiss Society of Food Science and Technology (SGLWT/SOSSTA) and the International Union of Food Science and Technology (IUFoST)}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0023-6438}, doi = {10.1016/j.lwt.2017.12.034}, pages = {164 -- 171}, year = {2018}, abstract = {A growing number of health-conscious individuals supplements their diet with protein-rich plant-based products to reduce their meat consumption. Analytical methods are needed to authenticate these new vegetarian products not only for the correct labelling of ingredients according to European legislation but also to discourage food fraud. This paper presents new biomarkers for a targeted proteomics LC-MS/MS work-flow that can simultaneously prove the presence/absence of garden pea, a protein-rich legume, meat and honey and quantify their content in processed vegan food. We show a novel rapid strategy to identify biomarkers for species authentication and the steps for the multi-parameter LC-MS/MS method validation and quantification. A high resolution triple time of flight mass spectrometer (HRMS) with SWATH Acquisition was used for the rapid discovery of all measurable trypsin-digested proteins in the individual ingredients. From these proteins, species-selective biomarkers were identified with BLAST and Skyline. Vicilin and convicilin (UniProt: D3VND9, Q9M3X6) allow pea authentication with regard to other legume species. Myostatin (UniProt: 018831) is a single biomarker for all meat types. For honey, we identified three selective proteins (UniProt: C6K481, C6K482, Q3L6329). The final LC-MS/MS method can identity and quantify these markers simultaneously. Quantification occurs via external matrix calibration.}, language = {en} } @article{HanneforthMalettiQuernheim2018, author = {Hanneforth, Thomas and Maletti, Andreas and Quernheim, Daniel}, title = {Pushing for weighted tree automata}, series = {Logical Methods in Computer Science}, volume = {14}, journal = {Logical Methods in Computer Science}, number = {1}, publisher = {Logical Methods in Computer Science E V}, address = {Braunschweig}, issn = {1860-5974}, doi = {10.23638/LMCS-14(1:5)2018}, pages = {16}, year = {2018}, abstract = {A weight normalization procedure, commonly called pushing, is introduced for weighted tree automata (wta) over commutative semifields. The normalization preserves the recognized weighted tree language even for nondeterministic wta, but it is most useful for bottom-up deterministic wta, where it can be used for minimization and equivalence testing. In both applications a careful selection of the weights to be redistributed followed by normalization allows a reduction of the general problem to the corresponding problem for bottom-up deterministic unweighted tree automata. This approach was already successfully used by Mohri and Eisner for the minimization of deterministic weighted string automata. Moreover, the new equivalence test for two wta M and M′ runs in time O((|M|+|M′|)⋅log(|Q|+|Q′|)), where Q and Q′ are the states of M and M′, respectively, which improves the previously best run-time O(|M|⋅|M′|).}, language = {en} } @article{KuhlmannBogumil2018, author = {Kuhlmann, Sabine and Bogumil, J{\"o}rg}, title = {Performance measurement and benchmarking as "reflexive institutions" for local governments}, series = {International journal of public sector management}, volume = {31}, journal = {International journal of public sector management}, number = {4}, publisher = {Emerald Group Publishing Limited}, address = {Bingley}, issn = {0951-3558}, doi = {10.1108/IJPSM-01-2017-0004}, pages = {543 -- 562}, year = {2018}, abstract = {Purpose The purpose of this paper is to discuss different approaches of performance measurement and benchmarking as reflexive institutions for local governments in England, Germany and Sweden from a comparative perspective. Design/methodology/approach These three countries have been selected because they represent typical (most different) cases of European local government systems and reforms. The existing theories on institutional reflexivity point to the potential contribution of benchmarking to public sector innovation and organizational learning. Based on survey findings, in-depth case studies, interviews and document analyses in these three countries, the paper addresses the major research question as to what extent and why benchmarking regimes vary across countries. It derives hypotheses about the impacts of benchmarking on institutional learning and innovation. Findings The outcomes suggest that the combination of three key features of benchmarking, namely - obligation, sanctions and benchmarking authority - in conjunction with country-specific administrative context conditions and local actor constellations - influences the impact of benchmarking as a reflexive institution. Originality/value It is shown in the paper that compulsory benchmarking on its own does not lead to reflexivity and learning, but that there is a need for autonomy and leeway for local actors to cope with benchmarking results. These findings are relevant because policy makers must decide upon the specific governance mix of benchmarking exercises taking their national and local contexts into account if they want them to promote institutional learning and innovation.}, language = {en} }