@article{FelisattiLaubrockShakietal.2020, author = {Felisatti, Arianna and Laubrock, Jochen and Shaki, Samuel and Fischer, Martin H.}, title = {Commentary}, series = {Frontiers in Human Neuroscience}, volume = {14}, journal = {Frontiers in Human Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2020.00099}, pages = {4}, year = {2020}, language = {en} } @article{HusainYadav2020, author = {Husain, Samar and Yadav, Himanshu}, title = {Target Complexity Modulates Syntactic Priming During Comprehension}, series = {Frontiers in Psychology}, volume = {11}, journal = {Frontiers in Psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2020.00454}, pages = {17}, year = {2020}, abstract = {Syntactic priming is known to facilitate comprehension of the target sentence if the syntactic structure of the target sentence aligns with the structure of the prime (Branigan et al., 2005; Tooley and Traxler, 2010). Such a processing facilitation is understood to be constrained due to factors such as lexical overlap between the prime and the target, frequency of the prime structure, etc. Syntactic priming in SOV languages is also understood to be influenced by similar constraints (Arai, 2012). Sentence comprehension in SOV languages is known to be incremental and predictive. Such a top-down parsing process involves establishing various syntactic relations based on the linguistic cues of a sentence and the role of preverbal case-markers in achieving this is known to be critical. Given the evidence of syntactic priming during comprehension in these languages, this aspect of the comprehension process and its effect on syntactic priming becomes important. In this work, we show that syntactic priming during comprehension is affected by the probability of using the prime structure while parsing the target sentence. If the prime structure has a low probability given the sentential cues (e.g., nominal case-markers) in the target sentence, then the chances of persisting with the prime structure in the target reduces. Our work demonstrates the role of structural complexity of the target with regard to syntactic priming during comprehension and highlights that syntactic priming is modulated by an overarching preference of the parser to avoid rare structures}, language = {en} } @article{ZiegeTheodorouJuenglingetal.2020, author = {Ziege, Madlen and Theodorou, Panagiotis and J{\"u}ngling, Hannah and Merker, Stefan and Plath, Martin and Streit, Bruno and Lerp, Hannes}, title = {Population genetics of the European rabbit along a rural-to-urban gradient}, series = {Scientific Reports}, volume = {10}, journal = {Scientific Reports}, publisher = {Nature Publ. Group}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-020-57962-3}, pages = {12}, year = {2020}, abstract = {The European rabbit (Oryctolagus cuniculus) is declining in large parts of Europe but populations in some German cities remained so far unaffected by this decline. The question arises of how urbanization affects patterns of population genetic variation and differentiation in German rabbit populations, as urban habitat fragmentation may result in altered meta-population dynamics. To address this question, we used microsatellite markers to genotype rabbit populations occurring along a rural-to-urban gradient in and around the city of Frankfurt, Germany. We found no effect of urbanization on allelic richness. However, the observed heterozygosity was significantly higher in urban than rural populations and also the inbreeding coefficients were lower, most likely reflecting the small population sizes and possibly on-going loss of genetic diversity in structurally impoverished rural areas. Global FST and G'ST-values suggest moderate but significant differentiation between populations. Multiple matrix regression with randomization ascribed this differentiation to isolation-by-environment rather than isolation-by-distance. Analyses of migration rates revealed asymmetrical gene flow, which was higher from rural into urban populations than vice versa and may again reflect intensified agricultural land-use practices in rural areas. We discuss that populations inhabiting urban areas will likely play an important role in the future distribution of European rabbits.}, language = {en} } @article{DechBittmannSchaefer2020, author = {Dech, Silas and Bittmann, Frank and Schaefer, Laura}, title = {Behavior of oxygen saturation and blood filling in the venous capillary system of the biceps brachii muscle during a fatiguing isometric action}, series = {European Journal of Translational Myology}, volume = {30}, journal = {European Journal of Translational Myology}, number = {1}, publisher = {Unipress}, address = {Padova}, issn = {2037-7460}, doi = {10.4081/ejtm.2019.8800}, pages = {79 -- 87}, year = {2020}, abstract = {The objective of the study is to develop a better understanding of the capillary circulation in contracting muscles. Ten subjects were measured during a submaximal fatiguing isometric muscle action by use of the O2C spectrophotometer. In all measurements the capillary-venous oxygen saturation of hemoglobin (SvO2) decreases immediately after the start of loading and levels off into a steady state. However, two different patterns (type I and type II) emerged. They differ in the extent of deoxygenation (-10.37 ±2.59 percent points (pp) vs. -33.86 ±17.35 pp, P = .008) and the behavior of the relative hemoglobin amount (rHb). Type I reveals a positive rank correlation of SvO2 and rHb (? = 0.735, P <.001), whereas a negative rank correlation (? = -0.522, P <.001) occurred in type II, since rHb decreases until a reversal point, then increases averagely 13\% above the baseline value and levels off into a steady state. The results reveal that a homeostasis of oxygen delivery and consumption during isometric muscle actions is possible. A rough distinction in two types of regulation is suggested.}, language = {en} } @article{PuschmannDriessleinBecketal.2020, author = {Puschmann, Anne-Katrin and Drießlein, David and Beck, Heidrun and Arampatzis, Adamantios and Moreno Catal{\´a}, Maria and Schiltenwolf, Marcus and Mayer, Frank and Wippert, Pia-Maria}, title = {Stress and Self-Efficacy as Long-Term Predictors for Chronic Low Back Pain}, series = {Journal of Pain Research}, volume = {13}, journal = {Journal of Pain Research}, publisher = {Dove Medical Press}, address = {Albany, Auckland}, issn = {1178-7090}, doi = {10.2147/JPR.S223893}, pages = {613 -- 621}, year = {2020}, abstract = {Purpose: Psychosocial variables are known risk factors for the development and chronification of low back pain (LBP). Psychosocial stress is one of these risk factors. Therefore, this study aims to identify the most important types of stress predicting LBP. Self-efficacy was included as a potential protective factor related to both, stress and pain. Participants and Methods: This prospective observational study assessed n = 1071 subjects with low back pain over 2 years. Psychosocial stress was evaluated in a broad manner using instruments assessing perceived stress, stress experiences in work and social contexts, vital exhaustion and life-event stress. Further, self-efficacy and pain (characteristic pain intensity and disability) were assessed. Using least absolute shrinkage selection operator regression, important predictors of characteristic pain intensity and pain-related disability at 1-year and 2-years follow-up were analyzed. Results: The final sample for the statistic procedure consisted of 588 subjects (age: 39.2 (± 13.4) years; baseline pain intensity: 27.8 (± 18.4); disability: 14.3 (± 17.9)). In the 1-year follow-up, the stress types "tendency to worry", "social isolation", "work discontent" as well as vital exhaustion and negative life events were identified as risk factors for both pain intensity and pain-related disability. Within the 2-years follow-up, Lasso models identified the stress types "tendency to worry", "social isolation", "social conflicts", and "perceived long-term stress" as potential risk factors for both pain intensity and disability. Furthermore, "self-efficacy" ("internality", "self-concept") and "social externality" play a role in reducing pain-related disability. Conclusion: Stress experiences in social and work-related contexts were identified as important risk factors for LBP 1 or 2 years in the future, even in subjects with low initial pain levels. Self-efficacy turned out to be a protective factor for pain development, especially in the long-term follow-up. Results suggest a differentiation of stress types in addressing psychosocial factors in research, prevention and therapy approaches.}, language = {en} } @article{MuellerDawczynskiWiestetal.2020, author = {M{\"u}ller, Sandra and Dawczynski, Christine and Wiest, Johanna and Lorkowski, Stefan and Kipp, Anna Patricia and Schwerdtle, Tanja}, title = {Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study}, series = {Nutrients}, volume = {12}, journal = {Nutrients}, number = {3}, publisher = {MDPI}, address = {Basel}, issn = {2072-6643}, doi = {10.3390/nu12030676}, pages = {14}, year = {2020}, abstract = {Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se}, language = {en} } @article{ReegHeineMihanetal.2020, author = {Reeg, Jette and Heine, Simon and Mihan, Christine and McGee, Sean and Preuss, Thomas G. and Jeltsch, Florian}, title = {A graphical user interface for the plant community model IBC-grass}, series = {Plos One}, volume = {15}, journal = {Plos One}, number = {3}, publisher = {Plos 1}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0230012}, pages = {18}, year = {2020}, abstract = {Plants located adjacent to agricultural fields are important for maintaining biodiversity in semi-natural landscapes. To avoid undesired impacts on these plants due to herbicide application on the arable fields, regulatory risk assessments are conducted prior to registration to ensure proposed uses of plant protection products do not present an unacceptable risk. The current risk assessment approach for these non-target terrestrial plants (NTTPs) examines impacts at the individual-level as a surrogate approach for protecting the plant community due to the inherent difficulties of directly assessing population or community level impacts. However, modelling approaches are suitable higher tier tools to upscale individual-level effects to community level. IBC-grass is a sophisticated plant community model, which has already been applied in several studies. However, as it is a console application software, it was not deemed sufficiently user-friendly for risk managers and assessors to be conveniently operated without prior expertise in ecological models. Here, we present a user-friendly and open source graphical user interface (GUI) for the application of IBC-grass in regulatory herbicide risk assessment. It facilitates the use of the plant community model for predicting long-term impacts of herbicide applications on NTTP communities. The GUI offers two options to integrate herbicide impacts: (1) dose responses based on current standard experiments (acc. to testing guidelines) and (2) based on specific effect intensities. Both options represent suitable higher tier options for future risk assessments of NTTPs as well as for research on the ecological relevance of effects.}, language = {en} } @article{Linker2020, author = {Linker, Torsten}, title = {Addition of Heteroatom Radicals to endo-Glycals}, series = {Chemistry}, volume = {2}, journal = {Chemistry}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2624-8549}, doi = {10.3390/chemistry2010008}, pages = {80 -- 92}, year = {2020}, abstract = {Radical reactions have found many applications in carbohydrate chemistry, especially in the construction of carbon-carbon bonds. The formation of carbon-heteroatom bonds has been less intensively studied. This mini-review will summarize the efforts to add heteroatom radicals to unsaturated carbohydrates like endo-glycals. Starting from early examples, developed more than 50 years ago, the importance of such reactions for carbohydrate chemistry and recent applications will be discussed. After a short introduction, the mini-review is divided in sub-chapters according to the heteroatoms halogen, nitrogen, phosphorus, and sulfur. The mechanisms of radical generation by chemical or photochemical processes and the subsequent reactions of the radicals at the 1-position will be discussed. This mini-review cannot cover all aspects of heteroatom-centered radicals in carbohydrate chemistry, but should provide an overview of the various strategies and future perspectives}, language = {en} } @article{ListekHoenowGossenetal.2020, author = {Listek, Martin and H{\"o}now, Anja and Gossen, Manfred and Hanack, Katja}, title = {A novel selection strategy for antibody producing hybridoma cells based on a new transgenic fusion cell line}, series = {Scientific Reports}, volume = {10}, journal = {Scientific Reports}, publisher = {Macmillan Publishers Limited, part of Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-020-58571-w}, pages = {12}, year = {2020}, abstract = {The use of monoclonal antibodies is ubiquitous in science and biomedicine but the generation and validation process of antibodies is nevertheless complicated and time-consuming. To address these issues we developed a novel selective technology based on an artificial cell surface construct by which secreted antibodies were connected to the corresponding hybridoma cell when they possess the desired antigen-specificity. Further the system enables the selection of desired isotypes and the screening for potential cross-reactivities in the same context. For the design of the construct we combined the transmembrane domain of the EGF-receptor with a hemagglutinin epitope and a biotin acceptor peptide and performed a transposon-mediated transfection of myeloma cell lines. The stably transfected myeloma cell line was used for the generation of hybridoma cells and an antigen- and isotype-specific screening method was established. The system has been validated for globular protein antigens as well as for haptens and enables a fast and early stage selection and validation of monoclonal antibodies in one step.}, language = {en} } @article{MoffittJuangSyed2020, author = {Moffitt, Ursula Elinor and Juang, Linda P. and Syed, Moin}, title = {Intersectionality and Youth Identity Development Research in Europe}, series = {Frontiers in Psychology}, volume = {11}, journal = {Frontiers in Psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2020.00078}, pages = {14}, year = {2020}, abstract = {The increasing application of intersectionality to the psychological study of identity development raises questions regarding how we as researchers construct and operationalize social identity categories, as well as how we best capture and address systems of oppression and privilege within our work. In the continental European context, the use of the intersectionality paradigm raises additional issues, since "race" was officially removed from the vernacular following the atrocities of WWII, yet racialized oppression continues to occur at every level of society. Within psychological research, participants are often divided into those with and without "migration background," which can reiterate inequitable norms of national belonging while washing over salient lived experiences in relation to generation status, citizenship, religion, gender, and the intersection between these and other social locations. Although discrimination is increasingly examined in identity development research, rarely are the history and impact of colonialism and related socio-historical elements acknowledged. In the current paper, we aim to address these issues by reviewing previous research and discussing theoretical and practical possibilities for the future. In doing so, we delve into the problems of trading in one static social identity category (e.g., "race") for another (e.g., "migration background/migrant") without examining the power structures inherent in the creation of these top-down categories, or the lived experiences of those navigating what it means to be marked as a racialized Other. Focusing primarily on contextualized ethno-cultural identity development, we discuss relevant examples from the continental European context, highlighting research gaps, points for improvement, and best practices.}, language = {en} }