@article{RottkeHeyneReinicke2020, author = {Rottke, Falko O. and Heyne, Marie-Victoria and Reinicke, Stefan}, title = {Switching enzyme activity by a temperature responsive inhibitor modified polymer}, series = {Chemical communications}, volume = {56}, journal = {Chemical communications}, number = {16}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1359-7345}, doi = {10.1039/c9cc09385k}, pages = {2459 -- 2462}, year = {2020}, abstract = {A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.}, language = {en} }