TY  - JOUR
A1  - Niedl, Robert Raimund
A1  - Beta, Carsten
T1  - Hydrogel-driven paper-based microfluidics
T2  - LAB on a chip : miniaturisation for chemistry and biology
N2  - Paper-based microfluidics provide an inexpensive, easy to use technology for point-of-care diagnostics in developing countries. Here, we combine paper-based microfluidic devices with responsive hydrogels to add an entire new class of functions to these versatile low-cost fluidic systems. The hydrogels serve as fluid reservoirs. In response to an external stimulus, e.g. an increase in temperature, the hydrogels collapse and release fluid into the structured paper substrate. In this way, chemicals that are either stored on the paper substrate or inside the hydrogel pads can be dissolved, premixed, and brought to reaction to fulfill specific analytic tasks. We demonstrate that multi-step sequences of chemical reactions can be implemented in a paper-based system and operated without the need for external precision pumps. We exemplify this technology by integrating an antibody-based E. coli test on a small and easy to use paper device.
Y1  - 2015
UR  - https://publishup.uni-potsdam.de/frontdoor/index/index/docId/8107
SN  - 1473-0197
SN  - 1473-0189
VL  - 11
IS  - 15
SP  - 2452
EP  - 2459
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -